CN109010526A - One kind is for the antibacterial clean Traditional Chinese medicine gel composition of maintenance of vaginal mucosa - Google Patents
One kind is for the antibacterial clean Traditional Chinese medicine gel composition of maintenance of vaginal mucosa Download PDFInfo
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- CN109010526A CN109010526A CN201810969773.9A CN201810969773A CN109010526A CN 109010526 A CN109010526 A CN 109010526A CN 201810969773 A CN201810969773 A CN 201810969773A CN 109010526 A CN109010526 A CN 109010526A
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- extract
- vagina
- mucosa
- maintenance
- chinese medicine
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- 210000004877 mucosa Anatomy 0.000 title claims abstract description 15
- 238000012423 maintenance Methods 0.000 title claims abstract description 11
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- 239000000203 mixture Substances 0.000 title claims abstract description 10
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 8
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 8
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 241000717739 Boswellia sacra Species 0.000 claims abstract description 8
- 102000008186 Collagen Human genes 0.000 claims abstract description 8
- 108010035532 Collagen Proteins 0.000 claims abstract description 8
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 8
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- 235000014220 Rhus chinensis Nutrition 0.000 claims abstract description 8
- 229940116229 borneol Drugs 0.000 claims abstract description 8
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920001436 collagen Polymers 0.000 claims abstract description 8
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 8
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- 235000020237 cranberry extract Nutrition 0.000 claims abstract description 7
- 239000008213 purified water Substances 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 6
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 6
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 6
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 5
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- 239000001717 vitis vinifera seed extract Substances 0.000 claims abstract description 5
- 244000061520 Angelica archangelica Species 0.000 claims abstract 3
- 239000000284 extract Substances 0.000 claims description 24
- 235000003717 Boswellia sacra Nutrition 0.000 claims description 9
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- 239000000706 filtrate Substances 0.000 claims description 6
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- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 4
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- 235000014787 Vitis vinifera Nutrition 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 239000004570 mortar (masonry) Substances 0.000 claims description 4
- 244000068988 Glycine max Species 0.000 claims description 3
- 235000010469 Glycine max Nutrition 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims description 3
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- 210000001215 vagina Anatomy 0.000 abstract description 20
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- 239000012466 permeate Substances 0.000 abstract description 2
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- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 2
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- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
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- 229920001817 Agar Polymers 0.000 description 1
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- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 description 1
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 description 1
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- 206010070834 Sensitisation Diseases 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
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- 238000012795 verification Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A—HUMAN NECESSITIES
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Alternative & Traditional Medicine (AREA)
- Insects & Arthropods (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Husbandry (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides one kind for the antibacterial clean Traditional Chinese medicine gel composition of maintenance of vaginal mucosa, it is made of the raw material of following weight ratio: Cranberry extract, twine imperial son, Chinese gall, grape seed extract, the root of Dahurain angelica, kuh-seng, olibanum, Radix Angelicae Sinensis, borneol, menthol, collagen, Sodium Hyaluronate, remaining is purified water, product of the invention enters after vagina, affected part can be diffused to rapidly, pharmaceutical composition permeates vagina mucosa, destroy pernicious bacteria growing environment, then go deep into vagina and gradually clear up the harmful bacteria being attached to inside vagina, repair damaged vagina mucosa, vagina mucosa is promoted normally to generate secretion, the autoimmunity of vagina is set gradually to be restored, for safeguarding the normal weakly acidic condition of vagina, restore the self-cleaning bacteriostasis of vagina, it nourishes lubricious, there is fabulous maintenance effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to one kind is for the antibacterial clean Traditional Chinese medicine gel of maintenance of vaginal mucosa
Composition.
Background technique
The vagina mucosa of female reproductive system refers to the holding vaginal walls surface wettability of vaginal walls secretion, keeps table
The mucus film layer of face vigor, due to various reasons, vagina can be by pathogenic infection, or because of the colony balance and soda acid of vagina by women
Equilibrium problem causes vaginal environment to change, and leads to colporrhagia or various gynaecological diseases, in terms of Chinese medicine angle, fungi vaginosis
Etiology and pathogenesis mostly because of insufficiency of the spleen resulting in production of dampness, damp flowing downward to lower-JIAO；The etiology and pathogenesis of trichomonas vaginitis mainly because of stagnated heat of liver channel, intrinsic heat at
Caused by worm；The etiology and pathogenesis main mechanism of senile vahinitis is the deficiency of liver-yin and kidney-yin, and damp invasion of lower energizer, vaginitis gives women's daily life
It causes to perplex, may result in infertile, serious influence life and health.
Summary of the invention
According to above-mentioned elaboration, the purpose of the present invention is to provide a kind of Chinese medicine composition gels, for inhibiting vaginal mucosa
Infection, with activating microcirculation and removing stasis medicinal, the effect of antibacterial anti-inflammatory.
Technical solution provided by the invention: one kind being used for the antibacterial clean Traditional Chinese medicine gel composition of maintenance of vaginal mucosa, is
It is made of the raw material of following weight ratio:
Cranberry extract 5%~10% twines imperial son 3%~7%, nutgall extractive 5%~20%, grape pip extraction
Object 5%~25%, propolis extract 1%~5%, Angelica Dahurica extract 10%~15%, shrubby sophora extract 10%~30%, olibanum
5%~20%, angelica extract 1%~5%, borneol 1%~3%, menthol 1%~3%, collagen 1%~2%, thoroughly
Bright matter acid sodium 1%~2%, remaining is purified water；
A kind of preparation method for the antibacterial clean Traditional Chinese medicine gel composition of maintenance of vaginal mucosa provided by the invention is:
Q1, by the raw material: Cranberry extract twines imperial son, nutgall extractive, grape seed extract, bee
Glue extract, Angelica Dahurica extract, shrubby sophora extract, angelica extract mixing, are stirred for mixed liquor A；
Q2, it takes pure frankincense to set in suitable ceramic bowl vessel, appropriate hot water is added, water level is closed slightly exceeding medicinal material surface
In heating in steamer until drug takes out after melting completely, surface impurity is got rid of, and with filtered through gauze, filtrate is spare；Filter residue
Add a little hot water to continue heating until all melting, with preceding step same operation filter residue, filtrate will merge twice, 65 DEG C of constant temperature add
Heat is poured out and is spread in square position, be put into baking oven until moisture evaporates as thick lotion, to soft tack-free for degree, taking-up,
Soya bean size particles are cut into, standing is dried in the shade spare；A certain amount of olibanum particle is taken, is set in mortar, even it is cold to be put into refrigerator together for cream hammer
Freeze indoor, quick-frozen 2 hours, taking out pressure immediately, to be ground into frankincense spare；
Q3, mixed liquor A and frankincense, menthol, borneol collagen, Sodium Hyaluronate are poured into stainless steel in proportion
In vessel, appropriate purified water is added, gelled is at the uniform velocity sufficiently stirred, that is, can be made into, packs vacuum sealing, places shady and cool, dry
Dry place's storage.
The extraction of Chinese medicine uses aqueous solvent extracting mode, the effective component of extraction.
The present invention based on the pathology and treatment principle to vaginal disease, compatibility rationally, science, through a large amount of clinical verifications,
It has no toxic side effect, product of the invention enters after vagina, can diffuse to affected part rapidly, and pharmaceutical composition permeates vagina mucosa, breaks
Bad pernicious bacteria growing environment then gos deep into vagina and gradually clears up the harmful bacteria being attached to inside vagina, repairs damaged vagina
Mucous membrane promotes vagina mucosa normally to generate secretion, the autoimmunity of vagina is made gradually to be restored, for maintenance women yin
The normal weakly acidic condition in road restores the self-cleaning bacteriostasis of vagina, and nourishing is lubricious, there is fabulous maintenance effect.
Specific embodiment
Technical solution of the present invention is clearly and completely described below, it is clear that described embodiment is only this
Invention a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art exist
Every other embodiment obtained under the premise of creative work is not made, shall fall within the protection scope of the present invention.
Compatibility of drugs of the invention is reasonable, and component effect is:
Cranberry, cool, sweet, sour, return heart, kidney channel can prevent urethral infection.
Twine imperial son, it is acrid flavour, sweet, it is mild-natured, it tonifies the liver and kidney, astringent sperm contracting urine, miscarriage prevention, improving eyesight, antidiarrheal；External application disappears wind nti-freckle.
Chinese gall, sour, puckery, cold in nature, return lung, large intestine, kidney channel, hemostasis, hygroscopic sore.
Grape pip can go deep into cell, fundamentally inhibit the release of sensitizing factor " histamine ", improve cell to anaphylactogen
Tolerance；Remove sensitization free radical, anti-inflammatory, antiallergy；Stablize skin heart tissue, effectively adjusting immunity of organisms.
Kuh-seng, bitter is cold in nature, return heart, liver, stomach, large intestine, bladder meridian, has heat-clearing, eliminating dampness, and the effect of desinsection can control drop
Worm property vaginitis.
Radix Angelicae Sinensis, it is sweet in flavor, pungent, bitter, it is warm-natured, enter liver, the heart, the spleen channel, it can be with blood-nourishing and blood, tonifying blood and regulating menstruation, promoting blood circulation and stopping pain.
Olibanum, acrid flavour, hardship are warm-natured.Return heart, liver, the spleen channel, the present invention utilize olibanum promoting blood circulation analgesic therapy, the function of detumescence and promoting granulation.
Propolis has the effect of moisturizing myogenic, anti-inflammatory analgetic.
The effect of root of Dahurain angelica, warm-natured, acrid flavour, hardship attach to the lung and stomach meridians, and the present invention is using root of Dahurain angelica antipyretic-antalgic, anti-inflammatory, antibacterial.
Borneol, acrid flavour, hardship, cold nature, return heart, spleen, lung channel have the effect of heat-clearing dissipates poison.
Menthol, external application is used for local analgesia, antipruritic.
The benefits of Sodium Hyaluronate plays lubrication moisturizing and nourishing, restores epidermis smooth resilient.
Collagen has good biocompatibility, biodegradable and bioactivity, plays to moisten herein and support
Shield effect.
According to above-mentioned component and compatibility principle analysis, the present invention, following embodiment is disclosed.
Embodiment:
Take: one kind is by the raw material of following parts by weight for the antibacterial clean Traditional Chinese medicine gel composition of maintenance of vaginal mucosa
It is made:
Cranberry extract 10g that Cranberry effective content is 40%, effective content are 30% to twine imperial seed extract
Propolis 10g that nutgall extractive 10g that 10g, effective content are 40%, propolis effective content are 35%, matrine effectively contain
Measuring the shrubby sophora extract 10g for 98%, the angelica extract 20g that Radix Angelicae Sinensis effective content is 25%, grape pip effective content is
30% grape seed extract 10g, Angelica Dahurica extract 10g, borneol 10g, the menthol 10g that root of Dahurain angelica effective content is 30%, thoroughly
Bright matter acid sodium 10g, collagen 10g add purified water to 1000g.
When production:
Q1, by the raw material: Cranberry extract twines imperial son, nutgall extractive, grape seed extract, bee
Glue extract, Angelica Dahurica extract, shrubby sophora extract, angelica extract mixing, are stirred for mixed liquor A；
Q2, it takes pure frankincense to set in suitable ceramic bowl vessel, appropriate hot water is added, water level is closed slightly exceeding medicinal material surface
In heating in steamer until drug takes out after melting completely, surface impurity is got rid of, and with filtered through gauze, filtrate is spare；Filter residue
Add a little hot water to continue heating until all melting, with preceding step same operation filter residue, filtrate will merge twice, 65 DEG C of constant temperature add
Heat is poured out and is spread in square position, be put into baking oven until moisture evaporates as thick lotion, to soft tack-free for degree, taking-up,
Soya bean size particles are cut into, standing is dried in the shade spare；A certain amount of olibanum particle is taken, is set in mortar, even it is cold to be put into refrigerator together for cream hammer
Freeze indoor, quick-frozen 2 hours, taking out pressure immediately, to be ground into frankincense spare；
Q3, mixed liquor A and frankincense, menthol, borneol collagen, Sodium Hyaluronate are poured into stainless steel in proportion
In vessel, appropriate purified water is added, gelled is at the uniform velocity sufficiently stirred, that is, can be made into, packs vacuum sealing, places shady and cool, dry
Dry place's storage.
In use, Chinese medicine composition gel is injected intravaginal by patient.
To show fungistatic effect of the invention, the embodiment of the present invention does bacteriostatic test:
One, equipment
1, test strain: Escherichia coli (8099) are cultivated 9 generations, Candida albicans (ATCC10231), culture 9 generations, golden yellow
Color staphylococcus (ATCC6538) cultivated for 9 generations, is provided by Chinese Culture Collection Center.
2, general English agar medium, sabouraud's agar are provided by Beijing road and bridge technology Co., Ltd.
3/0.03mol/L phosphate buffer solution (PBS)
4, carrier: filter paper (2.0cm × 3.0cm), sterile measuring pipette, sterilized petri dishes, sterile test tube, constant incubator
Deng
Two, sample is the present embodiment 5g, is put into sterile mortar grinding, crushes, mixes, is put into sterilized petri dishes and is directly pressed down
Bacterium test.
Three, method is according to GB15979-200 " Disposable Sanitary Accessory sanitary standard " appendix C 4, " disinfection technology rule
Model " 2002 editions 2.1.8 test.
Bacteriostatic test is carrier test, and 20 DEG C ± 1 DEG C of test temperature, test is repeated 3 times.
Four, result
Under conditions of 20 DEG C ± 2 DEG C of test temperature, embodiment is to Escherichia coli, Candida albicans, Staphylococcus aureus
Bacterium inhibitory effect.
The embodiment of the present invention is shown in Table 1 to the inhibitory effect inspection of staphylococcus aureus；
The inhibitory effect of 1 staphylococcus aureus of table
The embodiment of the present invention is shown in Table 2 for the inhibitory effect inspection of Candida albicans.
The inhibitory effect of 2 Candida albicans of table
The embodiment of the present invention is shown in Table 3 to the inhibitory effect inspection of Escherichia coli；
The inhibitory effect of 3 Escherichia coli of table
The conclusion tested above, for embodiment to Escherichia coli, Candida albicans, staphylococcus aureus inhibiting rate are reachable
90% or more.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (1)
1. one kind is for the antibacterial clean Traditional Chinese medicine gel composition of maintenance of vaginal mucosa, it is characterised in that: be by following weight ratio
Raw material be made: Cranberry extract 5%~10% twines imperial sub 3%~7%, nutgall extractive 5%~20%, grape pip
Extract 5%~25%, propolis extract 1%~5%, Angelica Dahurica extract 10%~15%, shrubby sophora extract 10%~30%,
Olibanum 5%~20%, angelica extract 1%~5%, borneol 1%~3%, menthol 1%~3%, collagen 1%~
2%, Sodium Hyaluronate 1%~2%, remaining is purified water；
Preparation method is:
Q1, by the raw material: Cranberry extract twines imperial son, nutgall extractive, grape seed extract, propolis and mentions
Object, Angelica Dahurica extract, shrubby sophora extract, angelica extract mixing are taken, mixed liquor A is stirred for；
Q2, it takes pure frankincense to set in suitable ceramic bowl vessel, appropriate hot water is added, water level is enclosed within steaming slightly exceeding medicinal material surface
Heating in pot gets rid of surface impurity until drug takes out after melting completely, and with filtered through gauze, and filtrate is spare；Filter residue adds few
Perhaps hot water continues heating until all melting, and with preceding step same operation filter residue, filtrate will merge twice, 65 DEG C of heated at constant temperature are straight
It evaporates to moisture as thick lotion, pours out and spread in square position, be put into baking oven, until it is soft tack-free for degree, it takes out, is cut into
Soya bean size particles, standing are dried in the shade spare；A certain amount of olibanum particle is taken, is set in mortar, even cream hammer is put into freezer compartment of refrigerator together
Interior, quick-frozen 2 hours, taking out pressure immediately, to be ground into frankincense spare；
Q3, mixed liquor A and frankincense, menthol, borneol collagen, Sodium Hyaluronate are poured into stainless steel ware in proportion
In, appropriate purified water is added, gelled is at the uniform velocity sufficiently stirred, that is, can be made into, packs vacuum sealing, places at shady and cool, dry
Storage.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110478477A (en) * | 2019-09-20 | 2019-11-22 | 王其兵 | A kind of traditional Chinese biological preparation and preparation method thereof promoting female reproductive health |
| CN110613839A (en) * | 2019-10-28 | 2019-12-27 | 田兰 | Chinese medicinal biological preparation for acting on female reproductive system and preparation method thereof |
| CN114588253A (en) * | 2022-04-27 | 2022-06-07 | 云南康旭生物科技有限公司 | Pharmaceutical composition for repairing and preventing vaginal mucosa aging and preparation thereof |
| CN115054740A (en) * | 2022-08-18 | 2022-09-16 | 北京世纪伟信医药科技有限公司 | Hypoallergenic collagen peptide human body cavity lubricant and preparation method thereof |
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2018
- 2018-08-23 CN CN201810969773.9A patent/CN109010526A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110478477A (en) * | 2019-09-20 | 2019-11-22 | 王其兵 | A kind of traditional Chinese biological preparation and preparation method thereof promoting female reproductive health |
| CN110613839A (en) * | 2019-10-28 | 2019-12-27 | 田兰 | Chinese medicinal biological preparation for acting on female reproductive system and preparation method thereof |
| CN114588253A (en) * | 2022-04-27 | 2022-06-07 | 云南康旭生物科技有限公司 | Pharmaceutical composition for repairing and preventing vaginal mucosa aging and preparation thereof |
| CN114588253B (en) * | 2022-04-27 | 2022-12-09 | 云南康旭生物科技有限公司 | Pharmaceutical composition for repairing and preventing vaginal mucosa aging and preparation thereof |
| CN115054740A (en) * | 2022-08-18 | 2022-09-16 | 北京世纪伟信医药科技有限公司 | Hypoallergenic collagen peptide human body cavity lubricant and preparation method thereof |
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