CN109602696A - A kind of chlorhexidine acetate bacteriostatic gel and preparation method thereof - Google Patents
A kind of chlorhexidine acetate bacteriostatic gel and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of chlorhexidine acetate bacteriostatic gels, it include: 0.05-0.3 parts of kuh-seng root extract, 0.05-0.3 parts of cnidium monnieri berry extract, 0.1-0.5 parts of Leonurus extract, 0.05-0.3 parts of Gotu Kola P.E, 0.1-0.5 parts of purslane extract, 0.05-0.3 parts of glycyrrhiza glabra extract, 0.3-0.8 parts of Fructus Kochiae extract;0.4-0.6 parts of ethyl alcohol, 0.1-0.2 parts of chlorhexidine acetate;1-3 parts of hydroxyethyl cellulose, 4-6 parts of glycerol, 1-3 parts of propylene glycol, 88-90 parts of water.The present invention is by the way that by the kuh-seng root extract of certain content, cnidium monnieri berry extract, Leonurus extract, Gotu Kola P.E, purslane extract, glycyrrhiza glabra extract, Fructus Kochiae extract, totally seven kinds of Chinese medical extracts carry out each components 5 and match and the synergistic function of drug effect, it is aided with the components such as the chlorhexidine acetate of certain content, the chlorhexidine acetate bacteriostatic gel being prepared to Escherichia coli, staphylococcus aureus, Candida albicans bacteriostasis rate have 90% or more fungistatic effect, female vulva itch, peculiar smell, the symptom of vaginitis can significantly be mitigated.
Description
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of chlorhexidine acetate bacteriostatic gel and preparation method thereof.
Background technique
Women's health is more and more paid close attention to, and various Gynecological health articles occurs.General health treatment is more
For oral preparation, its health effect is very unobvious, has larger side effect, and hormone-content is high, easily leads to human body interior point
Secrete imbalance.External drug is big to skin irritation, allergic symptom easily occurs and the problem of without bactericidal effect, and in the market mostly
For number product based on Chinese materia medica preparation, general fungistatic effect is bad.Furthermore there are also suppository classes, lotion for the antimicrobial for the treatment of gynaecological imflammation
Class, spray class etc., but most drugs can generate destruction to genital tract environment, mucous membrane itself secreting function, so as to cause reproduction
The decline of local immunity, and pathogenic bacteria is caused to develop drug resistance and drug resistance, final inflammation recurrent exerbation.
It, should if Chinese invention patent application CN201210039685.1 describes a kind of germicide for skin and preparation method thereof
Germicide for skin includes ginkgo leaf juice, feverfew juice, RADIX SOLANI juice, kudzuvine root juice, argy wormwood leaf juice, purslane extract, Bulbus Allii Fistulosi juice, distillation
The components such as water.But the antibacterial agent fungistatic effect is poor, and cannot effectively treat gynecological disease and cleaning skin, Chinese materia medica preparation conduct
Bacteriostatic agent, fungistatic effect are poor.
Summary of the invention
It is in view of the above-mentioned drawbacks of the prior art or insufficient, the primary purpose of the present invention is that providing a kind of fungistatic effect
Good, curative effect is stablized, and is able to maintain the clean chlorhexidine acetate bacteriostatic gel of women privates.The gelling agent is to Escherichia coli, gold
Staphylococcus aureus, Candida albicans bacteriostasis rate have 90% or more fungistatic effect, can significantly mitigate female vulva scabies
Itch, peculiar smell, the symptom of vaginitis.
Another object of the present invention is to provide the preparation method of above-mentioned chlorhexidine acetate bacteriostatic gel.
Chlorhexidine acetate bacteriostatic gel of the present invention, by weight, including following component:
0.05-0.3 parts of kuh-seng root extract, 0.05-0.3 parts of cnidium monnieri berry extract, 0.1-0.5 parts of Leonurus extract, accumulated snow
Careless extract 0.05-0.3 parts, 0.1-0.5 parts of purslane extract, 0.05-0.3 parts of glycyrrhiza glabra extract, the fruit of summer cypress extracts
0.3-0.8 parts of object;
0.4-0.6 parts of ethyl alcohol, 0.1-0.2 parts of chlorhexidine acetate;
1-3 parts of hydroxyethyl cellulose, 4-6 parts of glycerol, 1-3 parts of propylene glycol, 88-90 parts of water.
Preferably, chlorhexidine acetate bacteriostatic gel of the present invention, by weight, including following component:
0.1 part of kuh-seng root extract, 0.1 part of cnidium monnieri berry extract, 0.2 part of Leonurus extract, 0.1 part of Gotu Kola P.E,
0.2 part of purslane extract, 0.1 part of glycyrrhiza glabra extract, 0.5 part of Fructus Kochiae extract;
0.5 part of ethyl alcohol, 0.12 part of chlorhexidine acetate;
2 parts of hydroxyethyl cellulose, 5 parts of glycerol, 2 parts of propylene glycol, 89.08 parts of water.
Radix sophorae is the root of kuh-seng Sophora flavescens Ait., and bitter is cold in nature, has heat-clearing and damp-drying drug, diuresis
Antipyretic, wind-dispelling stops skin and itches, bitter taste stomach invigorating, and the function of expelling parasite sterilization cures mainly enteritis and dysentery, enterorrhagia, hemorrhoid hemorrhage, hepatitis jaundice,
Eczema, pudendal pruritus, psoriasis, boil, lambliasis.
Cnidium monnieri fruit is the dry mature fruit of umbelliferae cnidium monnieri Cnidium monnieri (L.) Cuss..It is distributed in
The ground such as East China, Central-South, southwestern, northwest, North China, northeast.With the effect of eliminating dampness wind-dispelling, desinsection is antipruritic, warming kidney and enhancing body.It is usually used in
Pruritus vulvae leukorrhagia, eczema itch, arthritis with fixed pain caused by dampness pain in the loins, impotence due to deficiency of the kidney, uterus cold infertile.
Motherwort is Labiatae, mother wort plant, summer-flowering.Its dry aerial parts is conventional Chinese medicine, and China is big
Some areas produce, and raw use or cook paste are used.1 year or biennial herb whole nation most area are distributed, and are born in hill famine
Ground, ridge, meadow etc..It is picked in the summer riotous growth non-standard-sized sheet of flower, acrid flavour is bitter, cool, invigorates blood circulation, silt of dispelling, menstruation regulating, disappear water, controls
Menoxenia is treated, vaginal bleeding during pregnancy is had difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, and hematuria rushes down blood, carbuncle swells sore
Ulcer.
Centella is Umbelliferae perennial herb, and stem is crawled, elongated, is taken root on section.All herbal medicine, clearing heat and promoting diuresis, detumescence
Removing toxic substances, controls acute diseases such as cholera and sunstroke xenon abdominal pain, heat rushes down, the leaching of dysentery, jaundice with damp-heat pathogen, sand, blood strangury, spit, blood, hemoptysis, hot eyes, larynx are swollen, rubeola, scabies,
Malignant boil carbuncle swells poison, traumatic injury etc..
Purslane is Caryophyllales, Portulacaceae annual herb, and complete stool is hairless.Herb hyoscine has clearing heat and promoting diuresis, removing toxic substances
Detumescence anti-inflammatory, is quenched the thirst, diuresis.
Glycyrrhiza glabra, the generally referred to as stem of glycyrrhiza glabra, main component are that glycyrrhiza glabra element and glycyrrhiza glabra are fixed, are had
It antioxygenic activity very strong depigmentation of skin, the function that lightens the stain.And antibacterial anti-inflammatory, anti-oxidant, anti-aging, antiultraviolet, it is sun-proof,
Whitening skin lightening, nti-freckle and other effects are obvious.
The fruit of summer cypress is the dry mature fruit of chenopod summer cypress, and China's most area is distributed, cold in nature, sweet in flavor
Hardship has clearing heat and promoting diuresis, dispelling wind and arresting itching and other effects, for diseases such as difficulty and pain in micturition, pruritus vulvae leukorrhagia, rubeola, eczema, pruituses.
It mainly contains the chemical components such as triterpenoid saponin, volatile oil and flavones, has resisting pathogenic microbes, anti-inflammatory, antiallergy, hypoglycemic
With the pharmacological activity such as anti-mucosal lesion, modern studies have found that fruit of summer cypress water extract has centainly a variety of common pathogens of gynaecological disease
Inhibiting effect, gynaecological disease control aspect have a better effect.
Chlorhexidine acetate bacteriostatic gel of the present invention is mainly by radix sophorae, cnidium monnieri fruit, motherwort, centella, purslane, light
Fruit Radix Glycyrrhizae, seven kinds of the fruit of summer cypress have heat-clearing and damp-drying drug, desinsection is antipruritic, wind-dispelling removing toxic substances Chinese medical extract composition, play Chinese medicine compound prescription
Integrally-regulated advantage, the growth and breeding of various bacteria can be significantly inhibited, to Escherichia coli, staphylococcus aureus, white
The bacteriostasis rate of candida albicans etc. has 90% or more fungistatic effect.
In addition, the present invention also provides the preparation methods of above-mentioned chlorhexidine acetate bacteriostatic gel, comprising the following steps:
(1) by hydroxyethyl cellulose, glycerol, mixed with propylene glycol, water is added after hydroxyethyl cellulose dissolution in stirring, and stirring adds
Heat keeps the temperature 20 minutes to 95 DEG C, and composition A is made;
Kuh-seng root extract, cnidium monnieri berry extract, Leonurus extract, Gotu Kola P.E, purslane extract, light fruit is sweet
Careless extract, Fructus Kochiae extract mixing, are made composition B;
Chlorhexidine acetate is dissolved in ethyl alcohol, composition C is made;
(2) composition A is cooled to 45 DEG C, composition B is then added, stirs evenly;
(3) continue to be cooled to 40 DEG C or less obtained gels under stiring, composition C is added, stirs evenly, obtains chlorhexidine acetate
Bacteriostatic gel.
The chlorhexidine acetate bacteriostatic gel that the present invention is prepared, when use can it is filling in disposable vaginal to gel
It is administered in device, uses 3.5g every time.
Compared with prior art, beneficial effects of the present invention are as follows:
1) present invention is by extracting the kuh-seng root extract of certain content, cnidium monnieri berry extract, Leonurus extract, centella
Object, purslane extract, glycyrrhiza glabra extract, Fructus Kochiae extract totally seven kinds of Chinese medical extracts carry out each components 5 match and
The synergistic function of drug effect is aided with the components such as the chlorhexidine acetate of certain content, and the chlorhexidine acetate being prepared is antibacterial solidifying
Jelly to Escherichia coli, staphylococcus aureus, Candida albicans bacteriostasis rate have 90% or more fungistatic effect, Neng Gouxian
It writes and mitigates female vulva itch, peculiar smell, the symptom of vaginitis, and it is uneasy to recur, so as to effectively keep women privates to clean.
2) preparation method of chlorhexidine acetate bacteriostatic gel of the present invention, it is simple to operation, it is suitable for large-scale work
Industry metaplasia produces.
Specific embodiment
Further illustrate that the present invention, following embodiment are the specific embodiment party of the present invention below by specific embodiment
Formula, but embodiments of the present invention are not limited by following embodiments.
Each component employed in the embodiment of the present invention is commercially available in market.
The inhibitory effect measuring method of the gelling agent, specific as follows:
(1) it is as shown in table 1 to measure strain used for strain inhibitory effect:
Table 1
Experimental strain | Assay medium | Cultivation temperature/DEG C | Incubation time |
Escherichia coli | Pancreas junket soya peptone agar medium or pancreas junket soya peptone fluid nutrient medium | 30-35 | 18-24h |
Staphylococcus aureus | Pancreas junket soya peptone agar medium or pancreas junket soya peptone fluid nutrient medium | 30-35 | 18-24h |
Candida albicans | Pancreas junket soya peptone agar medium or pancreas junket soya peptone fluid nutrient medium | 20-25 | 24-48h |
(2) prepared by bacterium solution
If agar culture, suitable 0.9% aseptic sodium chloride solution is added and elutes the culture of agar surface, and by bacterium
Suspension moves in sterile test tube, and being diluted with 0.9% aseptic sodium chloride solution and every 1ml is made containing bacterium number is about 108The bacterium of cfu is outstanding
Liquid;If fluid nutrient medium, thalline were collected by centrifugation, is diluted with 0.9% aseptic sodium chloride solution and every 1ml is made containing bacterium number and be about
108The bacteria suspension of cfu.
If being placed at room temperature after bacterium solution preparation, used in Ying 2h;If being stored in 2-8 DEG C, can be used interior for 24 hours.
(3) it is inoculated with
To each strain, 3-5 parts of inventive gel are taken, is directly inoculated with;Or appropriate inventive gel is taken to be transferred to 9-15 respectively
In a suitable sterile chamber (every 3-5 container is inoculated with a strain), connecing bacterium amount in 1g or 1ml gel is 105-106Cfu connects
The volume of kind bacterium solution must not exceed the 1% of inoculation gel volume;It is sufficiently mixed, is uniformly distributed the strain in gel, then sets
20-25 DEG C of stored protected from light.
(4) survival Counting alive microbial
In defined interval time, 1ml(g is sampled from above-mentioned each container respectively), bacterium number contained in every part of sample is tested,
To be converted into corresponding bacteriostasis rate.
Embodiment 1
A kind of chlorhexidine acetate bacteriostatic gel, by weight, including following component:
0.1 part of kuh-seng root extract, 0.1 part of cnidium monnieri berry extract, 0.2 part of Leonurus extract, 0.1 part of Gotu Kola P.E,
0.2 part of purslane extract, 0.1 part of glycyrrhiza glabra extract, 0.5 part of Fructus Kochiae extract;
0.5 part of ethyl alcohol, 0.12 part of chlorhexidine acetate;
2 parts of hydroxyethyl cellulose, 5 parts of glycerol, 2 parts of propylene glycol, 89.08 parts of water.
The preparation method of chlorhexidine acetate bacteriostatic gel of the present invention, includes the following steps:
(1) by hydroxyethyl cellulose, glycerol, mixed with propylene glycol, water is added after hydroxyethyl cellulose dissolution in stirring, and stirring adds
Heat keeps the temperature 20 minutes to 95 DEG C, and composition A is made;
Kuh-seng root extract, cnidium monnieri berry extract, Leonurus extract, Gotu Kola P.E, purslane extract, light fruit is sweet
Careless extract, Fructus Kochiae extract mixing, are made composition B;
Chlorhexidine acetate is dissolved in ethyl alcohol, composition C is made;
(2) composition A is cooled to 45 DEG C, composition B is then added, stirs evenly;
(3) continue to be cooled to 40 DEG C or less obtained gels under stiring, composition C is added, stirs evenly, obtains chlorhexidine acetate
Bacteriostatic gel.
Embodiment 2
0.3 part of kuh-seng root extract, 0.05 part of cnidium monnieri berry extract, 0.1 part of Leonurus extract, 0.3 part of Gotu Kola P.E,
0.1 part of purslane extract, 0.05 part of glycyrrhiza glabra extract, 0.8 part of Fructus Kochiae extract;Other are the same as embodiment 1.
Embodiment 3
0.05 part of kuh-seng root extract, 0.3 part of cnidium monnieri berry extract, 0.5 part of Leonurus extract, Gotu Kola P.E 0.05
Part, 0.5 part of purslane extract, 0.3 part of glycyrrhiza glabra extract, 0.3 part of Fructus Kochiae extract;Other are the same as embodiment 1.
The test result of the fungistatic effect of chlorhexidine acetate bacteriostatic gel described in 2 embodiment 1-3 of table
Embodiment 1 | Embodiment 2 | Embodiment 3 | |
The bacteriostasis rate of Escherichia coli | 95% | 93% | 91% |
The bacteriostasis rate of staphylococcus aureus | 96% | 92% | 93% |
The bacteriostasis rate of Candida albicans | 95% | 92% | 92% |
Clinical testing data:
Choose 3 patients, using embodiment 1 prepare chlorhexidine acetate bacteriostatic gel, it is filling in disposable vaginal to gel
It is administered in device, continues 30 days, specific example is as follows one time a day using 3.5g every time:
Test example 1: Zhu;38 years old, has there is the vaginas aging premonitory symptom such as pruritus of vagina, lower body peculiar smell, abnormal leucorrhea in female;
The course for the treatment of: from April 17,17 days to 2018 March in 2018, adhere to being administered with chlorhexidine acetate bacteriostatic gel daily;
Curative effect: foregoing conditions all significantly mitigate.Therapeutic index is 100%.
Test example 2: what certain, female, 50 years old, bacterial infection, trichomonas, colpomycosis, vagina aging start plus
Speed;
The course for the treatment of: from June 4,4 days to 2018 May in 2018, adhere to being administered with chlorhexidine acetate bacteriostatic gel daily;
Curative effect: foregoing conditions all significantly mitigate.Therapeutic index is 99%.
Test example 3: Mr. Wang, female 30 years old, cause germ often to be invaded because of vaginal relaxation, inflammation relapse indications repeatedly;
The course for the treatment of: from August on September 27th, 27,1 2018, adhere to being administered with chlorhexidine acetate bacteriostatic gel daily;
Curative effect: foregoing conditions all significantly mitigate.Therapeutic index is 100%.
Claims (3)
1. a kind of chlorhexidine acetate bacteriostatic gel, which is characterized in that by weight, including following component:
0.05-0.3 parts of kuh-seng root extract, 0.05-0.3 parts of cnidium monnieri berry extract, 0.1-0.5 parts of Leonurus extract, accumulated snow
Careless extract 0.05-0.3 parts, 0.1-0.5 parts of purslane extract, 0.05-0.3 parts of glycyrrhiza glabra extract, the fruit of summer cypress extracts
0.3-0.8 parts of object;
0.4-0.6 parts of ethyl alcohol, 0.1-0.2 parts of chlorhexidine acetate;
1-3 parts of hydroxyethyl cellulose, 4-6 parts of glycerol, 1-3 parts of propylene glycol, 88-90 parts of water.
2. chlorhexidine acetate bacteriostatic gel according to claim 1, which is characterized in that by weight, including it is as follows
Component:
0.1 part of kuh-seng root extract, 0.1 part of cnidium monnieri berry extract, 0.2 part of Leonurus extract, 0.1 part of Gotu Kola P.E,
0.2 part of purslane extract, 0.1 part of glycyrrhiza glabra extract, 0.5 part of Fructus Kochiae extract;
0.5 part of ethyl alcohol, 0.12 part of chlorhexidine acetate;
2 parts of hydroxyethyl cellulose, 5 parts of glycerol, 2 parts of propylene glycol, 89.08 parts of water.
3. a kind of preparation method of chlorhexidine acetate bacteriostatic gel as claimed in claim 1 or 2, which is characterized in that including with
Lower step:
(1) by hydroxyethyl cellulose, glycerol, mixed with propylene glycol, water is added after hydroxyethyl cellulose dissolution in stirring, and stirring adds
Heat keeps the temperature 20 minutes to 95 DEG C, and composition A is made;
Kuh-seng root extract, cnidium monnieri berry extract, Leonurus extract, Gotu Kola P.E, purslane extract, light fruit is sweet
Careless extract, Fructus Kochiae extract mixing, are made composition B;
Chlorhexidine acetate is dissolved in ethyl alcohol, composition C is made;
(2) composition A is cooled to 45 DEG C, composition B is then added, stirs evenly;
(3) continue to be cooled to 40 DEG C or less obtained gels under stiring, composition C is added, stirs evenly, obtains chlorhexidine acetate
Bacteriostatic gel.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110063914A (en) * | 2019-05-21 | 2019-07-30 | 张静 | A plant extraction ferment cleans bubble |
CN112057370A (en) * | 2020-10-19 | 2020-12-11 | 青岛浩大生物科技工程有限责任公司 | Private antibacterial foaming agent and preparation method thereof |
CN112315900A (en) * | 2020-11-06 | 2021-02-05 | 南京道大药业有限公司 | Gel for nursing private parts of women |
CN116139233A (en) * | 2023-03-30 | 2023-05-23 | 天津美丽之约生物科技发展有限公司 | Female private care antibacterial liquid and preparation process thereof |
-
2019
- 2019-01-31 CN CN201910097605.XA patent/CN109602696A/en not_active Withdrawn
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110063914A (en) * | 2019-05-21 | 2019-07-30 | 张静 | A plant extraction ferment cleans bubble |
CN112057370A (en) * | 2020-10-19 | 2020-12-11 | 青岛浩大生物科技工程有限责任公司 | Private antibacterial foaming agent and preparation method thereof |
CN112315900A (en) * | 2020-11-06 | 2021-02-05 | 南京道大药业有限公司 | Gel for nursing private parts of women |
CN116139233A (en) * | 2023-03-30 | 2023-05-23 | 天津美丽之约生物科技发展有限公司 | Female private care antibacterial liquid and preparation process thereof |
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