CN112057370A - Private antibacterial foaming agent and preparation method thereof - Google Patents

Abstract

The invention discloses a private antibacterial foaming agent which comprises the following raw materials in parts by mass: 1 part of chlorhexidine gluconate, 10 parts of cocamidopropyl betaine, 5 parts of glycerol, 1 part of plant extract, 1 part of algal polysaccharide, 0.1 part of lavender oil and 10-15 parts of auxiliary materials; the plant extract comprises: radix Sophorae Flavescentis extract, fructus Cnidii extract, fructus Zanthoxyli extract, fructus Jujubae extract, rhizoma Smilacis Glabrae extract, and Kochiae fructus extract; the adjuvants include solubilizer PEG-40 hydrogenated castor oil, and chelating agent EDTA-2 NA. Has the advantages that: through the mutual synergistic effect of the Chinese herbal medicines, the effects of clearing heat, promoting diuresis, dispelling wind and arresting itching of the Chinese herbal medicines are better exerted, the result of an in-vitro antibacterial test shows that the product has the effect of 10min, the average sterilization rate of the product on candida albicans is 91.02%, the average sterilization rate of staphylococcus aureus is 99.85%, the average sterilization rate of escherichia coli is 99.81%, and the irritation of the product on vaginal mucosa is observed through an animal experiment.

Description

Private antibacterial foaming agent and preparation method thereof

Technical Field

The invention relates to the technical field of hygienic products, in particular to a private antibacterial foaming agent and a preparation method thereof.

Background

The skin and mucous membrane covered on the surface of the human body are the defense line of the human body against the invasion of external pathogenic microorganisms, and need to be cleaned, sterilized and disinfected frequently to ensure that the human body is not infected. The lotion is the most common daily use and largest consumption in daily life. Along with the improvement of economic living standard of people, the requirement on lotion is higher and higher, the lotion is not simple to clean the skin any more, and the feeling of moistening and smoothing brought by the lotion and the internal efficacy of the lotion are emphasized.

The common skin mucosa lotion on the market at present has the disadvantages of unobvious cleaning and sterilizing effect, obvious irritation and uncomfortable use. Moreover, most of the common lotion in the market contains more chemical substances, and is not beneficial to human health after long-term use. Therefore, naturally harmless lotions are becoming the direction of future development. Female consumption is a large expense in daily consumption, modern women pay more attention to skin care and health care, and women have different skins from men, so that the skins of the women are more sensitive, and the skin regulation must be paid more attention to. In addition, the physiological characteristics of women are special, three important opening parts of anus, vagina and urethra are concentrated, different substances are discharged from the openings respectively, and the openings can be infected and propagated by bacteria, viruses, mycoplasma, chlamydia, trichomonas and the like if people do not pay attention to cleaning, so that a series of uncomfortable symptoms are caused. Some of these symptoms can even lead to malignant lesions if left untreated or if not treated properly. The female lotion relates to mucosa cleaning, and compared with the lotion, the lotion needs to be milder, refreshing and low in residue, conforms to the physiological and metabolic characteristics of normal women, and achieves the balance of daily maintenance and self-antibacterial maintenance.

Various products are filled in the existing female antibacterial lotion market, and although the products are various, more women can be forbidden to the lotion. The private parts of healthy women are in a weakly acidic environment and can inhibit the invasion of most pathogenic bacteria, and the private part cleaning solution for women in the market is mostly alkaline, so that the acid-base imbalance of the private parts can be caused and the invasion of more pathogenic bacteria can be caused by frequent cleaning with the cleaning solution containing the alkaline components. And a bactericide containing chlorine is added into some cleaning liquid, wherein the chlorine is a strong oxidant, so that the cleaning liquid not only stimulates the skin and damages the pudendum, but also can kill most beneficial bacteria in the pudendum, so that the flora is out of balance, the body resistance is reduced, and more pathogenic bacteria are propagated. The lotion without antibiotics or bacteriostatic agents generally has slow action, long treatment time and difficult effect, has certain irritation to skin and vaginal mucosa, and can destroy vaginal flora to a certain extent and damage vaginal mucosa after long-term use.

In combination with the main problems of the products on the market at present, the lotion is designed into the lotion for women, which is added with the mild bacteriostatic agent, is specially used for the delicate skin and the weak acid environment of women, effectively inhibits the pathogenic bacteria and has no stimulation to the skin and the mucous membrane.

Disclosure of Invention

The invention aims to solve the problems that in the prior art, the female antibacterial lotion easily causes the acid-base imbalance of pudendum to cause the invasion of more pathogenic bacteria or has certain irritation to skin and vaginal mucosa, and provides a private antibacterial foaming agent and a preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme: a private antibacterial foaming agent comprises the following raw materials in parts by mass:

1-2 parts of chlorhexidine gluconate

5-10 parts of cocamidopropyl betaine

5-10 parts of glycerol

1-2 parts of plant extract

1-3 parts of algal polysaccharide

0.1-0.5 part of lavender oil

10-15 parts of auxiliary materials.

In the above private antimicrobial foam agent, the plant extract comprises: radix Sophorae Flavescentis extract, fructus Cnidii extract, fructus Zanthoxyli extract, fructus Jujubae extract, rhizoma Smilacis Glabrae extract, and Kochiae fructus extract;

the auxiliary materials comprise solubilizer PEG-40 hydrogenated castor oil and chelating agent EDTA-2 NA.

In the above private antibacterial foaming agent, the private antibacterial foaming agent comprises the following raw materials in parts by mass:

chlorhexidine gluconate 1 part

10 portions of cocamidopropyl betaine

5 parts of glycerin

Plant extract 1 part

Algal polysaccharide 1 part

0.1 part of lavender oil

10 parts of auxiliary materials.

In the private antibacterial foaming agent, the plant extract comprises the following components in parts by mass: 1.5 parts of radix sophorae flavescentis extract, 1.5 parts of fructus cnidii extract, 1.5 parts of pepper extract, 1.5 parts of jujube extract, 2 parts of rhizoma smilacis glabrae extract and 2 parts of fructus kochiae extract.

A preparation method of a private antibacterial foaming agent comprises the following steps:

s1, weighing glycerol and EDTA-2NA, adding into water, stirring for dissolving, heating to about 80 ℃, and keeping the temperature for 20 min;

s2, heating to about 75 ℃, adding cocamidopropyl betaine, stirring to dissolve completely, and then continuously cooling to about 45 ℃;

s3, adding chlorhexidine gluconate, plant extract and algal polysaccharide, stirring and dissolving completely;

s4, adding the premixed lavender oil and the PEG-40 hydrogenated castor oil, and stirring to dissolve completely to obtain the product.

Compared with the prior art, the invention has the advantages that:

1. the extracts of the radix sophorae flavescentis, the fructus cnidii, the pepper, the jujube, the rhizoma smilacis glabrae and the fructus kochiae are scientifically matched, and the effects of clearing heat, promoting diuresis, dispelling wind and relieving itching of the traditional Chinese medicine components are better exerted through the mutual synergistic effect of the Chinese herbal medicines;

2. through the optimal proportion of the biguanide mild antibacterial agent and the algal polysaccharide and the assistance of various plant extracts, the antibacterial and itching relieving effects of the product are ensured, the lavender oil is added to replace the synthetic essence, the flavor is removed, and meanwhile, the natural and safe fragrance experience is brought, and the body and mind are enjoyed.

3. The product is developed into a foaming agent form, so that the use is more convenient, and the cleaning is more thorough.

In-vitro antibacterial tests show that the product has the average sterilization rate of 91.02% for Candida albicans, 99.85% for Staphylococcus aureus and 99.81% for Escherichia coli after 10min of action, and animal experiments show that the product has no irritation to vaginal mucosa.

Detailed Description

The following examples are for illustrative purposes only and are not intended to limit the scope of the present invention.

Examples

A private antibacterial foaming agent comprises the following raw materials in parts by mass:

chlorhexidine gluconate 1 part

10 portions of cocamidopropyl betaine

5 parts of glycerin

Plant extract 1 part

Algal polysaccharide 1 part

0.1 part of lavender oil

10 parts of auxiliary materials.

The plant extract comprises the following components in parts by mass: 1.5 parts of radix sophorae flavescentis extract, 1.5 parts of fructus cnidii extract, 1.5 parts of pepper extract, 1.5 parts of jujube extract, 2 parts of rhizoma smilacis glabrae extract and 2 parts of fructus kochiae extract;

the adjuvants include solubilizer PEG-40 hydrogenated castor oil, and chelating agent EDTA-2 NA.

A preparation method of a private antibacterial foaming agent comprises the following steps:

s1, weighing glycerol and EDTA-2NA, adding into water, stirring for dissolving, heating to about 80 ℃, and keeping the temperature for 20 min;

s2, heating to about 75 ℃, adding cocamidopropyl betaine, stirring to dissolve completely, and then continuously cooling to about 45 ℃;

s3, adding chlorhexidine gluconate, plant extract and algal polysaccharide, stirring and dissolving completely;

s4, adding the premixed lavender oil and the PEG-40 hydrogenated castor oil, and stirring to dissolve completely to obtain the product.

The product has the advantages that the optimal ratio of the biguanide mild antibacterial agent to the marine polysaccharide and the assistance of various plant extracts are adopted, and on the basis, a surfactant and a formula system are further explored, so that the product which can effectively sterilize and mildly maintain private parts is finally developed.

The biguanide antibacterial agent chlorhexidine gluconate can be used for clinical application and washing and disinfection of mucous membrane tissues and wound surfaces, and has mild property;

phenolic hydroxyl in the algal polysaccharide can promote polyphenol to pass through cell membranes, enhance the interference of polyphenol on the structure and the function of bacterial cell membranes, destroy the integrity of the cell membranes and play an antibacterial role.

In the plant extracts, the radix sophorae flavescentis has the effects of clearing heat, eliminating dampness, resisting bacteria and relieving itching; the fructus cnidii can kill parasites, relieve itching, promote blood circulation and enrich blood; the pepper can dispel cold, dry dampness, promote qi circulation, relieve pain, sterilize and relieve itching; the jujube can tonify qi, benefit blood, nourish blood and soothe nerves; rhizoma Smilacis Glabrae has effects of promoting diuresis, eliminating dampness, resisting bacteria and virus; broom cypress fruit clears heat and promotes diuresis, dispels wind and stops itching. The lavender oil has certain antibacterial property and fragrant smell, brings sensory experience of plant fragrance while cleaning and removing the smell, replaces essence and spice used by common products, and is more natural and safer.

The invention greatly optimizes the mixture ratio of each component of the product and the collocation of the surface active system. A surface active system with mild foaming and strong cleaning power is constructed, and the biguanide antibacterial agent, the algal polysaccharide and the plant extract are added in multiple proportions, so that the product is weakly acidic, and is directly provided for consumers in a foam form without kneading. The components of the whole formula are natural in source, mild and non-irritant, and the antibacterial effect is obvious.

In-vitro antibacterial tests show that the product has the average sterilization rate of 91.02% for Candida albicans, 99.85% for Staphylococcus aureus and 99.81% for Escherichia coli after 10min of action, and animal experiments show that the product has no irritation to vaginal mucosa.

The above examples merely represent preferred embodiments of the present invention, which are described in more detail and detail, but are not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, various changes, modifications and substitutions can be made without departing from the spirit of the present invention, and these are all within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (5)

1. The private antibacterial foaming agent is characterized by comprising the following raw materials in parts by mass:

1-2 parts of chlorhexidine gluconate

5-10 parts of cocamidopropyl betaine

5-10 parts of glycerol

1-2 parts of plant extract

1-3 parts of algal polysaccharide

0.1-0.5 part of lavender oil

10-15 parts of auxiliary materials.

2. A intimate, antimicrobial foam formulation according to claim 1, wherein said plant extract comprises: radix Sophorae Flavescentis extract, fructus Cnidii extract, fructus Zanthoxyli extract, fructus Jujubae extract, rhizoma Smilacis Glabrae extract, and Kochiae fructus extract;

the auxiliary materials comprise solubilizer PEG-40 hydrogenated castor oil and chelating agent EDTA-2 NA.

3. The private antimicrobial foam according to claim 1, wherein the private antimicrobial foam comprises the following raw materials in parts by mass:

chlorhexidine gluconate 1 part

10 portions of cocamidopropyl betaine

5 parts of glycerin

Plant extract 1 part

Algal polysaccharide 1 part

0.1 part of lavender oil

10 parts of auxiliary materials.

4. The intimate, antibacterial, foam of claim 2, wherein said plant extract comprises, in parts by mass: 1.5 parts of radix sophorae flavescentis extract, 1.5 parts of fructus cnidii extract, 1.5 parts of pepper extract, 1.5 parts of jujube extract, 2 parts of rhizoma smilacis glabrae extract and 2 parts of fructus kochiae extract.

5. A preparation method of a private antibacterial foaming agent is characterized by comprising the following steps:

s1, weighing glycerol and EDTA-2NA, adding into water, stirring for dissolving, heating to 80 ℃, and keeping the temperature for 20 min;

s2, heating to 75 ℃, adding cocamidopropyl betaine, stirring to dissolve completely, and then continuously cooling to 45 ℃;

s3, adding chlorhexidine gluconate, plant extract and algal polysaccharide, stirring and dissolving completely;

s4, adding the premixed lavender oil and the PEG-40 hydrogenated castor oil, and stirring to dissolve completely to obtain the product.