CN108853311A - A kind of Traditional Chinese medicine gel composition antibacterial for vagina mucosa - Google Patents
A kind of Traditional Chinese medicine gel composition antibacterial for vagina mucosa Download PDFInfo
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A61P31/04—Antibacterial agents
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Abstract
The present invention provides a kind of Traditional Chinese medicine gel composition antibacterial for vagina mucosa, is made of the raw material of following weight ratio:Seabuckthorm Seed Oil,Aloe gel extract liquor,Radix scutellariae,The root of Dahurain angelica,Kuh-seng,Cortex Phellodendri,Frutus cnidii,Borneol,Menthol,Sodium hyaluronate,Remaining is purified water,The present invention is based on the pathology and treatment principle to vaginal disease,Compatibility is reasonable,Science,Through a large amount of clinical verifications,It has no toxic side effect,Product of the invention enters after vagina,Affected part can be diffused to rapidly,Pharmaceutical composition permeates vagina mucosa,Destroy pernicious bacteria growing environment,Then go deep into vagina and gradually clear up the harmful bacteria being attached to inside vagina,Repair damaged vagina mucosa,Vagina mucosa is promoted normally to generate secretion,The autoimmunity of vagina is set gradually to be restored,For safeguarding the normal weakly acidic condition of vagina,Restore the self-cleaning bacteriostasis of vagina,Firming and moisturizing,Antibacterial nourishing,It cleans antipruritic,Dispelling abnormal flavor,Private parts health is promoted to have fabulous maintenance effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to it is a kind of for vagina it is antibacterial nourish, keep vagina it is compact in
Medicinal gel composition.
Background technique
The vagina mucosa of female reproductive system refers to the holding vaginal walls surface wettability of vaginal walls secretion, keeps table
The mucus film layer of face vigor, due to various reasons, vagina can be by pathogenic infection, or because of the colony balance and soda acid of vagina by women
Equilibrium problem causes vaginal environment to change, and leads to colporrhagia or various gynaecological diseases, in terms of Chinese medicine angle, fungi vaginosis
Etiology and pathogenesis mostly because of insufficiency of the spleen resulting in production of dampness, damp flowing downward to lower-JIAO;The etiology and pathogenesis of trichomonas vaginitis mainly because of stagnated heat of liver channel, intrinsic heat at
Caused by worm;The etiology and pathogenesis main mechanism of senile vahinitis is the deficiency of liver-yin and kidney-yin, and damp invasion of lower energizer, vaginitis gives women's daily life
It causes to perplex, may result in infertile, serious influence life and health.
Summary of the invention
According to above-mentioned elaboration, the purpose of the present invention is to provide a kind of Chinese medicine composition gel, for inhibit private parts it is antibacterial,
Clean antipruritic, dispelling abnormal flavor effect.
Technical solution provided by the invention:A kind of Traditional Chinese medicine gel composition antibacterial for vagina mucosa, is by following heavy
The raw material of amount ratio is made:
Seabuckthorm Seed Oil 5%~10%, aloe gel extract liquor 3%~7%, Baical Skullcap root P.E 5%~20%, the root of Dahurain angelica extract
Object 10%~15%, shrubby sophora extract 10%~30%, phellodendron extract 5%~20%, common cnidium fruit P.E 1%~5%, ice
Piece 1%~3%, menthol 1%~3%, sodium hyaluronate 1%~3%, remaining is purified water;
Preparation method is:
A kind of preparation method of Traditional Chinese medicine gel composition antibacterial for vagina mucosa provided by the invention is:
Q1, by the raw material:Seabuckthorm Seed Oil, aloe gel extract liquor, Baical Skullcap root P.E, Angelica Dahurica extract, Huang
Cypress extract, shrubby sophora extract, common cnidium fruit P.E mixing, are stirred for mixed liquor A;
Q2, mixed liquor A and menthol, borneol, sodium hyaluronate are poured into stainless steel ware in proportion, appropriate purifying is added
Water is at the uniform velocity sufficiently stirred gelled, that is, can be made into, and packs vacuum sealing, places and stores at shady and cool, dry.
The extraction of Chinese medicine uses aqueous solvent extracting mode, the effective component of extraction.
The present invention based on the pathology and treatment principle to vaginal disease, compatibility rationally, science, through a large amount of clinical verifications,
It has no toxic side effect, product of the invention enters after vagina, can diffuse to affected part rapidly, and pharmaceutical composition permeates vagina mucosa, breaks
Bad pernicious bacteria growing environment then gos deep into vagina and gradually clears up the harmful bacteria being attached to inside vagina, repairs damaged vagina
Mucous membrane promotes vagina mucosa normally to generate secretion, the autoimmunity of vagina is made gradually to be restored, for maintenance women yin
The normal weakly acidic condition in road restores the self-cleaning bacteriostasis of vagina, and firming and moisturizing is antibacterial to nourish, clean antipruritic, dispelling abnormal flavor, promotees
There is fabulous maintenance effect into private parts health.
Specific embodiment
Technical solution of the present invention is clearly and completely described below, it is clear that described embodiment is only this
Invention a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art exist
Every other embodiment obtained under the premise of creative work is not made, shall fall within the protection scope of the present invention.
Compatibility of drugs of the invention is reasonable, and component effect is:
Seabuckthorm Seed Oil is saturating to brownish red by the brown color that seabuckthorn seeds are obtained by supercritical extract or subcritical low-temperature extraction
Bright oily liquids integrates the highly concentrated object of Effective Compositions of Seabuckthorn, includes flavones, organic acid, alkaloid, sterols, three
140 various bioactive components such as terpenes and various vitamins have obvious biological effect, anti-sense as medicinal raw material
Dye is by force, promotion healing is fast, has good and stable curative effect to Gynecological cervical inflammation, and the present invention is newly old using its nourishes rough skin, promotion
Metabolism, antiallergy, bactericidal antiphlogistic promote re-epithelilization, and the effect of skin repair keeps the acidic environment of vagina.
Aloe contains a large amount of amino acid, vitamin, polysaccharide compound, various enzymes and minerals, have bactericidal antiphlogistic,
Enhance immune function.
Radix scutellariae, cold in nature, bitter is tested through flat band method, and radix scutellariae is to Escherichia coli, proteus, Pseudomonas aeruginosa, staphylococcus
And fungi etc. has good bactericidal effect.
Cortex Phellodendri, bitter is cold in nature, and antibiotic effective ingredient is jamaicin, reads through in vitro test staphylococcus aureus, white
Pearl bacterium has stronger inhibiting effect.
Kuh-seng, bitter is cold in nature, return heart, liver, stomach, large intestine, bladder meridian, has heat-clearing, eliminating dampness, and the effect of desinsection can control drop
Worm property vaginitis.
Frutus cnidii, it is sweet in flavor, pungent, bitter, it is warm-natured, enter liver, the heart, the spleen channel, it can be with blood-nourishing and blood, tonifying blood and regulating menstruation, promoting blood circulation and stopping pain.
The effect of root of Dahurain angelica, warm-natured, acrid flavour, hardship attach to the lung and stomach meridians, and the present invention is using root of Dahurain angelica antipyretic-antalgic, anti-inflammatory, antibacterial.
Borneol, acrid flavour, hardship, cold nature, return heart, spleen, lung channel have the effect of heat-clearing dissipates poison.
Menthol, external application is used for local analgesia, antipruritic.
Sodium hyaluronate is that the biochemical drug with higher clinical value plays lubrication moisturizing and nourishing, restore epidermis smooth resilient,
Moisten maintenance action.
According to above-mentioned component and compatibility principle analysis, the present invention, following embodiment is disclosed.
Embodiment:
It takes:A kind of Traditional Chinese medicine gel composition antibacterial for vagina mucosa, is to be made from the following raw materials in parts by weight:
Seabuckthorm Seed Oil 100g, aloe gel extraction liquid extract 50g, effective content be 40% Baical Skullcap root P.E 150g,
It is common cnidium fruit P.E 50g that shrubby sophora extract 200g that matrine effective content is 98%, frutus cnidii effective content are 45%, white
The Angelica Dahurica extract 150g, borneol 30g, menthol 30g that root of Dahurian angelica effective content is 30%, sodium hyaluronate 30g add purified water to 1000g.
When production:
Q1, by the raw material:Seabuckthorm Seed Oil, aloe gel extract liquor, Baical Skullcap root P.E, Angelica Dahurica extract, Huang
Cypress extract, shrubby sophora extract, common cnidium fruit P.E mixing, are stirred for mixed liquor A;
Q2, mixed liquor A and menthol, borneol, sodium hyaluronate are poured into stainless steel ware in proportion, appropriate purifying is added
Water is at the uniform velocity sufficiently stirred gelled, that is, can be made into, and packs vacuum sealing, places and stores at shady and cool, dry.
In use, Chinese medicine composition gel is injected intravaginal by patient.
To show fungistatic effect of the invention, the embodiment of the present invention does bacteriostatic test:
One, equipment
1, test strain:Escherichia coli (8099) are cultivated 9 generations, Candida albicans (ATCC10231), culture 9 generations, golden yellow
Color staphylococcus (ATCC6538) cultivated for 9 generations, is provided by Chinese Culture Collection Center.
2, general English agar medium, sabouraud's agar are provided by Beijing road and bridge technology Co., Ltd.
3/0.03mol/L phosphate buffer solution (PBS)
4, carrier:Filter paper (2.0cm × 3.0cm), sterile measuring pipette, sterilized petri dishes, sterile test tube, constant incubator
Deng
Two, sample is the present embodiment 5g, is put into sterile mortar grinding, crushes, mixes, is put into sterilized petri dishes and is directly pressed down
Bacterium test.
Three, method is according to GB15979-200《Disposable Sanitary Accessory sanitary standard》Appendix C 4,《Disinfection technology rule
Model》2002 editions 2.1.8 test.
Bacteriostatic test is carrier test, and 20 DEG C ± 1 DEG C of test temperature, test is repeated 3 times.
Four, result
Under conditions of 20 DEG C ± 2 DEG C of test temperature, embodiment is to Escherichia coli, Candida albicans, Staphylococcus aureus
Bacterium inhibitory effect.
The embodiment of the present invention is shown in Table 1 to the inhibitory effect inspection of staphylococcus aureus;
The inhibitory effect of 1 staphylococcus aureus of table
The embodiment of the present invention is shown in Table 2 for the inhibitory effect inspection of Candida albicans.
The inhibitory effect of 2 Candida albicans of table
The embodiment of the present invention is shown in Table 3 to the inhibitory effect inspection of Escherichia coli;
The inhibitory effect of 3 Escherichia coli of table
The conclusion tested above, for embodiment to Escherichia coli, Candida albicans, staphylococcus aureus inhibiting rate are reachable
90% or more.
Embodiment takes one 5g of this product in use, after cleaning vulva, and using gel boost motor, user borrows solidifying after lying low
Glue boost motor is quiet after gel is pushed at vagina discomfort to lie, 1-2 times daily;This product cannot substitute drug, must not be used for sexual life
In prevention to venereal disease.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (2)
1. a kind of Traditional Chinese medicine gel composition antibacterial for vagina mucosa, it is characterised in that:It is by the raw material system of following weight ratio
At:Seabuckthorm Seed Oil 5%~10%, aloe gel extract liquor 3%~7%, Baical Skullcap root P.E 5%~20%, Angelica Dahurica extract
10%~15%, shrubby sophora extract 10%~30%, phellodendron extract 5%~20%, common cnidium fruit P.E 1%~5%, borneol
1%~3%, menthol 1%~3%, sodium hyaluronate 1%~3%, remaining is purified water;
Preparation method is:
Q1, by the raw material:Seabuckthorm Seed Oil, aloe gel extract liquor, Baical Skullcap root P.E, Angelica Dahurica extract, Cortex Phellodendri mention
Object, shrubby sophora extract, common cnidium fruit P.E mixing are taken, mixed liquor A is stirred for;
Q2, mixed liquor A and menthol, borneol, sodium hyaluronate are poured into stainless steel ware in proportion, appropriate purified water is added, it is even
Gelled is sufficiently stirred in speed, that is, can be made into, and packs vacuum sealing, places and stores at shady and cool, dry.
2. a kind of Traditional Chinese medicine gel composition antibacterial for vagina mucosa according to claim 1, it is characterised in that:Be by
The raw material of following weight ratio is made:Seabuckthorm Seed Oil 8%, aloe gel extract liquor 5%, Baical Skullcap root P.E 15%, Angelica Dahurica extract
12%, shrubby sophora extract 20%, phellodendron extract 15%, common cnidium fruit P.E 5%, borneol 3%, menthol 3%, sodium hyaluronate
3%, remaining is purified water.
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CN201811096009.1A CN108853311A (en) | 2018-09-19 | 2018-09-19 | A kind of Traditional Chinese medicine gel composition antibacterial for vagina mucosa |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109771545A (en) * | 2019-03-14 | 2019-05-21 | 盛荣秋实生物技术(广州)有限公司 | A kind of temperature sensitive bacteriostatic gel of intelligence |
CN110302302A (en) * | 2019-08-06 | 2019-10-08 | 阿谷巴科技(唐山)有限公司 | A kind of antibacterial liquid formulations |
CN111375037A (en) * | 2020-04-22 | 2020-07-07 | 上海融古堂实业有限公司 | Toxin-expelling inflammation-diminishing and vagina-shrinking pill for gynecology and preparation method thereof |
CN113134066A (en) * | 2021-05-07 | 2021-07-20 | 诸暨市博美生物科技有限公司 | Preparation method of gynecological gel |
CN113171418A (en) * | 2021-05-06 | 2021-07-27 | 刘丹婕 | Comfortable-avoiding antibacterial gel and pusher |
IT202000004582A1 (en) | 2020-03-06 | 2021-09-06 | Alfasigma Spa | PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT AND PREVENTION OF ATROPHY AND VAGINAL DRYNESS. |
CN114377075A (en) * | 2022-01-21 | 2022-04-22 | 福州艾蔓缇娜化妆品有限公司 | Cell vagina contracting liquid for female nursing and preparation process thereof |
-
2018
- 2018-09-19 CN CN201811096009.1A patent/CN108853311A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109771545A (en) * | 2019-03-14 | 2019-05-21 | 盛荣秋实生物技术(广州)有限公司 | A kind of temperature sensitive bacteriostatic gel of intelligence |
CN110302302A (en) * | 2019-08-06 | 2019-10-08 | 阿谷巴科技(唐山)有限公司 | A kind of antibacterial liquid formulations |
IT202000004582A1 (en) | 2020-03-06 | 2021-09-06 | Alfasigma Spa | PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT AND PREVENTION OF ATROPHY AND VAGINAL DRYNESS. |
CN111375037A (en) * | 2020-04-22 | 2020-07-07 | 上海融古堂实业有限公司 | Toxin-expelling inflammation-diminishing and vagina-shrinking pill for gynecology and preparation method thereof |
CN113171418A (en) * | 2021-05-06 | 2021-07-27 | 刘丹婕 | Comfortable-avoiding antibacterial gel and pusher |
CN113134066A (en) * | 2021-05-07 | 2021-07-20 | 诸暨市博美生物科技有限公司 | Preparation method of gynecological gel |
CN114377075A (en) * | 2022-01-21 | 2022-04-22 | 福州艾蔓缇娜化妆品有限公司 | Cell vagina contracting liquid for female nursing and preparation process thereof |
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Application publication date: 20181123 |