CN110384725A - A kind of preparation of Chinese traditional medicine composition and its activity extract for adjusting oral cavity flora - Google Patents
A kind of preparation of Chinese traditional medicine composition and its activity extract for adjusting oral cavity flora Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The present invention relates to Chinese-medicine oral cavity nursing technique field, the preparation method of a kind of Chinese traditional medicine composition for adjusting oral cavity flora and its activity extract is specifically disclosed.The Chinese traditional medicine composition includes: 20-30 parts of HERBA ELSHOLTZIAE, 20-25 parts of Radix Astragali, 10-20 parts of Hang Ju, 5-10 parts of honeysuckle in terms of mass fraction.HERBA ELSHOLTZIAE, the FLOS CHRYSANTHEMI from Hangzhou of China, honeysuckle of present invention selection Chinese herbal medicines, the compatibility together with Radix Astragali, as prevention and treatment oral peculiar smell, treatment canker sore or the Chinese medicine composition for alleviating periodontitis, and according to tcm causa morbi dialectical theory, HERBA ELSHOLTZIAE inducing diuresis for removing edema and middle dampness elimination, anti-inflammatory；Radix Astragali inducing diuresis for removing edema removes taking poison and growing muscle due；The clearing heat and detoxicating antibacterial of Hang Ju；Honeysuckle dispelling wind-heat, removing summer-heat blood poison, fragrance reach thoroughly and can eliminating evil.All taste raw materials pass through compatibility, the common effect for playing prevention and adjustment oral cavity flora.Using Chinese medicine combination or Chinese medicine compound prescription, mouth disease caused by capable of effectively preventing because of oral bacteria imbalance or certain pathogenic bacteria, oral care significant effect.
Description
Technical field
The invention belongs to Chinese-medicine oral cavity nursing technique fields, and in particular to a kind of for adjusting the Chinese traditional medicine composition of oral cavity flora
And its preparation of activity extract.
Background technique
Many people feel that oneself or other side have oral peculiar smell, and both sides is made to generate certain estrangement and distance in communication, right
Life and work produces a very large impact, and normal social interaction is made obstacle occur.Oral cavity field planting microorganism different parts commensalism,
Competition and antagonism, with host buccal health and disease relationship it is close, in the oral cavity, between microorganism, microorganism and host mouth
Only keep the dynamic ecological balance between chamber, oral cavity can just keep fit state, if oral cavity has adventive or oral cavity micro-
Intrinsic individual or several microorganism ratios obviously increase the dominant bacteria for becoming field planting position, oral microecosystem balance in ecology
It is broken, it will flora imbalance occur, lead to mouth disease.The distribution of oral peculiar smell patient's oral cavity flora and sum and normal population
There are significant difference, pathogenic bacteria quantity related with mouth disease is apparently higher than normal population, and pathogenic dominant bacteria decomposes mouth
Intracavitary substance generates volatile sulfide and fatty acid, and volatile sulfur compounds increased significantly in abnormal implication, mouth occurs
Cavity foreign flavor.
For the unbalance caused oral peculiar smell of Oral health behaviours, current solution is to solve flora imbalance.Common
It is treatment mouth disease, eliminates the generation of oral cavity pernicious gas, adjustment of diet improves hygienic habit, antibiotic treatment disease
Disease etc., and the substances such as chewing gum are used, reinforce oral hygiene and brush teeth daily, the use of the measures such as oral cavity gargle is also to have certain effect
Fruit.However the use of antibiotic is limited now, and often effect is single or effect is poor for number of types of gargle.It is existing
The oral care product of some traditional Chinese medicine ingredients is while having masking oral peculiar smell, without the adjustment for oral microorganism
Effect, or have certain killing effect to oral cavity harmful bacteria, but the effect in pure and fresh oral cavity cannot be provided.
Canker sore is common oral illness, as the rhythm of life study becomes faster, many people be easy often in it is nervous,
The big state of stress；Or since bad life habits, canker sore this " ciril disease " happen occasionally, canker sore is
It is common as flu.It usually grows in lip, the other positions of tongue or oral cavity, can often recur, be good or bad, irrespective of sex
It is old and young.Flora and host's symbiosis, ordinary circumstance system are in equilibrium state in oral cavity, if the oral cavity flora of this balance is destroyed,
Oral disease including canker sore just will appear, canker sore streptococcus intermedius group, Wei Rong Shi flora and Neisseria group,
The variation of these three bacterial contents will have a direct impact on Oral health behaviours balance.
Summary of the invention
The technical problems to be solved by the present invention are: existing adjustment oral cavity flora is directed to, to prevent and treat oral peculiar smell, control
It treats canker sore or alleviation periodontitis product effect is single, effect shortcomings and deficiencies not fully up to expectations, the present invention provides one kind
For adjusting the Chinese traditional medicine composition of oral cavity flora and its preparation method of activity extract.The present invention selects Chinese herbal medicines
HERBA ELSHOLTZIAE, chrysanthemum, honeysuckle, the compatibility together with Radix Astragali, as the Chinese medicine composition of prevention and treatment oral peculiar smell, and according to tcm causa morbi
Dialectical theory and drug matching medicine law are combined compatibility to Chinese medicine, and to reinforce oral care effect, all taste raw materials pass through
The compatibility theory of monarch, the common effect for playing prevention and adjustment oral cavity flora, so as to improve oral conditions.Using in sheet
Medicine combination or Chinese medicine compound prescription, mouth disease such as canker sore caused by capable of effectively preventing because of oral bacteria imbalance or certain pathogenic bacteria
With the generation of periodontosis, oral care significant effect.
The present invention adopts the following technical scheme that, Lai Shixian goal of the invention.
Firstly, the invention discloses a kind of for adjusting the Chinese traditional medicine composition of oral cavity flora, it is the direct mixing of Chinese medicine material
Object or activity extract.
The Chinese traditional medicine composition includes: 20-30 parts of HERBA ELSHOLTZIAE, 20-25 parts of Radix Astragali, 10-20 parts of Hang Ju, gold and silver in terms of mass fraction
5-10 parts of flower.
Elscholtiza is Lamiaceae plant Mosla chinensisMoslachinensisMax-imakOr HERBA ELSHOLTZIAEM.chinensis- Jiangxiangru.Dry aerial parts.First recorded in " Mingyi Bielu ", middle product are classified as, acrid flavour tepor has sweating solution
Table, inducing diuresis for removing edema and middle dampness elimination and other effects.Genunie medicinal materials of the HERBA ELSHOLTZIAE as elscholtiza have very big clinical medical value, existing
In generation, studies have shown that containing in HERBA ELSHOLTZIAE there are many chemical component, has antipyretic and anti-inflammatory equal pharmacological actions.HERBA ELSHOLTZIAE is for Chinese medicine
The important component of composition contains aromatic substance in HERBA ELSHOLTZIAE, the aromatic substance not only bacterium in counterpart, anaerobic bacteria, virus and
Producing sour enzyme has direct killing effect, and can inhibit bacterium, virus, anaerobic bacteria and the activity for producing sour enzyme, meets current proposition
Tune plaque microecological balance theory (Zhou Xuedong, Hu Tao, Li Jiyao plaque bionomic control new concept [J] foreign medical science
Dentistry fascicle, 1997 (06): 323-326;Hu Tao plaque microecology and its meaning [J] the state in mouth disease
Outer medicine dentistry fascicle, 1996 (02): 104-105.), and there is good oral health care effect.
Radix Astragali also known as the prince's descendants, hundred absorbent cotton, arrow stilbene are the dry root of leguminous plant Radix Astragali or Inner Mongolia Astragalis.Nature and flavor are sweet, micro-
Temperature, play the role of tonifying middle-Jiao and Qi, hidroschesis, inducing diuresis for removing edema, except taking poison and growing muscle due.Radix Astragali is on tcm clinical practice using very extensive.
Hang Ju, pungent, sweet, bitter, slightly cold, dispelling wind and heat from the body, calming the liver, improving eyesight, clearing away heat and toxic materials, to Escherichia coli, shigella dysenteriae, wound
Cold bacillus, paratyphosum Bacterium, mycetozoan and the bacteriums such as Pseudomonas aeruginosa and comma bacillus have complete inhibiting effect, to human body
Tubercle bacillus there are also inhibitory effects.
Honeysuckle, the sweet cold air fragrance of property, for clear heat with drugs of sweet flavour and cold nature without injuring one's stomach, fragrance reaches thoroughly again can eliminating evil.Honeysuckle can surname dissipate
Wind-heat, also kind removing summer-heat blood poison, is used for various febrile diseases, such as body heat, dermexanthesis, macular eruption, heat toxin sore carbuncle, abscess of throat disease, imitates
Fruit is significant.
The present invention selects HERBA ELSHOLTZIAE, the FLOS CHRYSANTHEMI from Hangzhou of China, honeysuckle of Chinese herbal medicines, the compatibility together with Radix Astragali, as tune
Whole oral cavity flora, the Chinese medicine composition for preventing and treating oral peculiar smell, wherein HERBA ELSHOLTZIAE inducing diuresis for removing edema and middle dampness elimination, anti-inflammatory, is for monarch
Medicine；Radix Astragali inducing diuresis for removing edema removes taking poison and growing muscle due, is the drug for assisting the reinforcement of monarch drug in a prescription HERBA ELSHOLTZIAE to treat main disease and main symptom, and for simultaneous sick
Or accompanying symptoms rise therapeutic effect drug, such as it can improve because inflammation caused by alveolar bone taken in excess the problem of；Hangzhoupro
The clearing heat and detoxicating antibacterial of chrysanthemum is to assist monarch drug in a prescription HERBA ELSHOLTZIAE, ministerial drug Radix Astragali to reinforce therapeutic effect and directly treat the effect of secondary accompanying symptoms；
Honeysuckle dispelling wind-heat, removing summer-heat blood poison, fragrance thoroughly up to again can eliminating evil, be guiding drug in we, all medicines guide drugs to illness station in the side of drawing
Drug, and energy coordinating the drug actions of a prescription, make its resultant force eliminating evil.All taste raw materials are common to play prevention and adjust oral cavity flora by compatibility
Effect, so as to improve oral conditions.Using Chinese medicine combination or Chinese medicine compound prescription, can effectively prevent because oral bacteria is lacked of proper care or certain
The generation of mouth disease caused by pathogenic bacteria such as canker sore and periodontosis, oral care significant effect.
Further, the adjustment oral cavity flora are as follows: oral peculiar smell caused by eliminating because of oral cavity harmful bacteria, prevention and treatment mouth
Chamber ulcer alleviates periodontitis.
Further, the direct mixture of the Chinese traditional medicine composition, be used to prepare adjustment oral cavity flora, prevention and treatment oral peculiar smell,
Anti- treating dental ulcer or the medical preparation for alleviating periodontitis.
Further, the activity extract of the Chinese traditional medicine composition is used to prepare adjustment oral cavity flora, improves oral hygiene work
Medical preparation, medical articles, dietary product, daily chemical products.
Further, the medical preparation has powder, pulvis, granula, capsule etc..
Further, the medical articles have gargle, chewable tablets, lozenge, effervescent tablet, jumping candy etc..
Further, the dietary product has beverage, biscuit, Yoghourt, jelly etc..
Further, the daily chemical products have medicated toothpaste etc..
Secondly, the invention also discloses a kind of for adjusting the preparation side of the Chinese traditional medicine composition activity extract of oral cavity flora
Method.
The preparation method the following steps are included: in S1, Chinese traditional medicine composition each Chinese medicine material crushing；S2, according to Chinese traditional medicine composition
Proportion, smashed each Chinese medicine material is uniformly mixed；S3, mixed Chinese medicine material is soaked in water；S4, Chinese medicine material are decocted
It boils；S5, it filters to decoct filtrate；S6, the concentration for decocting filtrate；S7, sterilizing packing, store it is spare.
Further, the time soaked in water described in step S3 is 0.5-2 h；It is 2- that Chinese medicine material described in step S4, which decocts,
3 times, each 0.5-1h；Concentration described in step S6 is to be concentrated under reduced pressure under the conditions of vacuum < -0.08MPa.
The utility model has the advantages that
(1) present invention is according to tcm causa morbi dialectical theory, HERBA ELSHOLTZIAE inducing diuresis for removing edema and middle dampness elimination, anti-inflammatory；Radix Astragali inducing diuresis for removing edema,
Except taking poison and growing muscle due；The clearing heat and detoxicating antibacterial of Hang Ju；Honeysuckle dispelling wind-heat, removing summer-heat blood poison, fragrance reaches thoroughly again can eliminating evil.HERBA ELSHOLTZIAE be for
The important component of Chinese medicine composition contains aromatic substance in HERBA ELSHOLTZIAE, the aromatic substance not only bacterium, anaerobic bacteria in counterpart
There is direct killing effect with virus and the sour enzyme of production, and bacterium, virus, anaerobic bacteria and the activity for producing sour enzyme can be inhibited,
It is theoretical to meet the tune plaque microecological balance proposed now, and there is good oral health care effect.HERBA ELSHOLTZIAE and Huang
Stilbene, honeysuckle and Hang Ju compatibility can more preferably play clearing heat and detoxicating, antiphlogistic effects, inhibit plaque to improve periodontitis, to slow down
The excessively too fast absorption of alveolar bone caused by periodontitis.All taste raw materials are common to play prevention and adjust oral cavity flora by compatibility
Effect, so as to improve oral conditions.
(2) present invention is by selecting the very high Chinese herbal medicines of safety, and passes through a large amount of safety and drug effect
Property test compare and analyze, continue to optimize screening product formula and formula rate；Product has carried out multinomial detection and analysis and reality
It tests, adjustment oral cavity flora inhibits the effect of bacterium obvious, highly-safe, non-evident effect, and market popularization value is high.
Detailed description of the invention
Fig. 1 is the microphoto that Chinese traditional medicine composition activity extract A influences rats with experimental periodontitis alveolar bone.
Specific embodiment
The present invention is further illustrated combined with specific embodiments below, but the present invention is not limited to following embodiments.
The method is conventional method unless otherwise instructed.The raw material can obtain unless otherwise instructed from public commercial source
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Embodiment 1: the preparation of Chinese traditional medicine composition activity extract A
According to following quality proportionings: 25 parts of HERBA ELSHOLTZIAE, 22.5 parts of Radix Astragali, 15 parts of Hang Ju, 7.5 parts of honeysuckle, first by each Chinese medicine
Raw material (dry product) is crushed；Secondly smashed each Chinese medicine material is uniformly mixed and soaks in water 1 h；In after immersion
Medicine raw material adds water to cook 3 times, and decocting time is respectively 1h, 0.5h, 0.5h three times, filters to decoct filtrate；It is then combined with decoction
Filtrate, and be concentrated under reduced pressure under the conditions of vacuum < -0.08MPa, stop concentration when until containing 10 g/ml of crude drug in medical fluid；Most
Afterwards sterilizing packing, store spare, obtain Chinese traditional medicine composition activity extract A.
Embodiment 2: the preparation of Chinese traditional medicine composition activity extract B
According to following quality proportionings: 30 parts of HERBA ELSHOLTZIAE, 20 parts of Radix Astragali, 20 parts of Hang Ju, 5 parts of honeysuckle, first by each Chinese medicine material
(dry product) is crushed；Secondly smashed each Chinese medicine material is uniformly mixed and soaks in water 2h；It is former to the Chinese medicine after immersion
Material adds water to cook 2 times, and secondary decocting time is respectively 1h, 1h, filters to decoct filtrate；It is then combined with and decocts filtrate, and true
It is concentrated under reduced pressure under the conditions of sky < -0.08MPa, stops concentration when until containing 10 g/ml of crude drug in medical fluid；Finally sterilizing packing,
It stores spare, obtains Chinese traditional medicine composition activity extract B.
Embodiment 3: the preparation of Chinese traditional medicine composition activity extract C
According to following quality proportionings: 20 parts of HERBA ELSHOLTZIAE, 25 parts of Radix Astragali, 10 parts of Hang Ju, 10 parts of honeysuckle, first by each Chinese medicine material
(dry product) is crushed；Secondly smashed each Chinese medicine material is uniformly mixed and soaks in water 0.5 h；To the Chinese medicine after immersion
Raw material adds water to cook 2 times, and secondary decocting time is respectively 1h, 0.5h, filters to decoct filtrate；It is then combined with and decocts filtrate, and
It is concentrated under reduced pressure under the conditions of vacuum < -0.08MPa, stops concentration when until containing 10 g/ml of crude drug in medical fluid；Finally sterilizing point
It fills, store spare, obtain Chinese traditional medicine composition activity extract C.
Embodiment 4: bacteriostatic experiment of the Chinese traditional medicine composition activity extract A to 9 kinds of reference cultures
By the obtained Chinese traditional medicine composition activity extract A of embodiment 1, it is diluted to required concentration with sodium chloride injection, is adopted
With test tube two-fold dilution's method, it is (staphylococcus aureus, big to 9 kinds of reference cultures to investigate the extract of various concentration composition
Intestines Escherichia, Candida albicans, pseudomonas aeruginosa, Friedlander's bacillus, Fusobacterium nucleatum, streptococcus mutans, stickiness
The general Salmonella of actinomyces, osculant) antibacterial situation, and measure its minimum inhibitory concentration.Metronidazule injection and mouth are selected simultaneously
Chamber inflammation spray (Heilungkiang sky dragon pharmaceutcal corporation, Ltd) compares.The results are shown in Table 1:
Table 1: the fungistatic effect of aerobic bacteria is compared
It was found from 1 experimental result of table: Chinese traditional medicine composition activity extract A has more significant bacteriostasis to aerobic and anaerobic bacteria.
Stomatitis spray wherein will be significantly better than to the fungistatic effect of escherichia coli, Candida albicans, Friedlander's bacillus；
Metronidazule injection will be significantly better than to the fungistatic effect of streptococcus mutans, the general Salmonella of osculant；And to staphylococcus aureus,
The fungistatic effect of pseudomonas aeruginosa and stomatitis spray are almost the same；Only to the suppression of Fusobacterium nucleatum and Actinomycesviscosus
Bacterium effect is slightly poorer to Metronidazule injection.
Embodiment 5: Healing Experiments of the Chinese traditional medicine composition activity extract A to experimental canker sore
By the obtained Chinese traditional medicine composition activity extract A of embodiment 1, it is diluted to required concentration with sodium chloride injection, it is right
Experimental canker sore healing is tested.Its experimental design, implementation Process and experimental result specifically:
40 rats are randomly divided into model control group, White Cloud Mountain Tangyin Dong Tai medicine company Co., Ltd ice boron lozenge group
(positive controls), this combination large dosage group, 4 groups of this combination small dose group, every group 10.Each group rat uses ether respectively
Anesthesia, lies on the back and is fixed on mouse plate.Taking a diameter is the glass tube of 4 mm;One cotton pellet is placed in one end, be allowed to
Nozzle is concordant;The cotton balls end of glass tube is immersed in the phenol solution that mass fraction is 900 g/L, medical fluid is made to be impregnated with cotton balls;
Place it in about 60 s of calcination on the cheek mucous membrane of rat side.Removing the i.e. visible region of glass tube has that 4~6 mm's of diameter is white
Color damage;Next day naked eyes visible rat lip side is moist, slobbers, red and swollen at cheek mucous membrane, i.e. canker sore modeling success.
This combination large dosage group: (the 15 of clinical day for human beings dosage are equivalent to 1250 μ L/100g weight of this combination
Again), at 5 instillation rat cheek mucosa ulcers of average mark, 2 h are spaced.
This combination small dose group: to 415 μ L/100g weight of this combination (5 times that are equivalent to clinical day for human beings dosage),
At 2 instillation rat cheek mucosa ulcers of average mark, it is spaced 4 h.
Ice boron lozenge group: giving 1.5 mg/g of ice boron lozenge powder, be placed at rat cheek mucosa ulcer for average mark 5 times,
Every 2 h.
Model control group is not administered.
For above-mentioned large dosage of group, small dose group, ice boron lozenge group, fasting, taboo 30 min of water after each medication, even
6 d of continuous administration.Rat canker sore healing state is observed before being administered daily, oral ulcer surface diameter after 6 d of record administration
Size (being indicated with mm) and the time and quantity of rat canker sore healing.Healing standard: ulcer diameter < 1mm is more
It closes, ulcer diameter >=1 mm is not heal.It the results are shown in Table 2.With model control group compare, 6 d of successive administration, this combination greatly,
Small dose group rat oral ulcer surface diameter reduces, and canker sore healing rat quantity increases, the statistically significant (P of difference
< 0.01 or P < 0.05), the results are shown in Table 2:
2 each group rat oral ulcer surface diameter of table compares x ± s
※There is conspicuousness (P < 0.05) with model group comparing difference,﹟There is conspicuousness (P < with positive controls comparing difference
0.05)
It was found from 2 experimental result of table: after experimental rat Oral ulcer model is successful, after drug application is treated,
Chinese traditional medicine composition activity extract A and positive drug group are reduced ulcer area, significant difference (P < 0.05).By the 6th day, Chinese medicine
Group is combined high dose and reaches extremely significant sex differernce (P < 0.01), with positive drug significant difference (P < 0.05), illustrates Chinese medicine group
Close the healing that can be obviously promoted Rat Experimental canker sore.
Embodiment 6: the extracorporeal bacteria inhibitor test of Chinese traditional medicine composition activity extract A
By the obtained Chinese traditional medicine composition activity extract A of embodiment 1, it is diluted to required concentration with sodium chloride injection, is adopted
Perfusion method is punched with plate, the In Vitro Bacteriostasis of staphylococcus aureus, escherichia coli and Candida albicans is tested.Its
Experimental design, implementation Process and experimental result specifically:
Sterilizing test tubes 7 are taken, is arranged on rack for test tube after number, according to aseptic manipulation, 1000 g/L are added in the 1st pipe
3 mL of Chinese medicine composition A, the 2nd~4 pipe respectively add 3 mL of sterile saline, then inhale 1000 g/L Chinese medicine composition A 3
After mL is added to the mixing of the 2nd pipe, 3 mL being sucked out and are added to the mixing of the 3rd pipe, the 3rd pipe is sucked out 3 mL and is added to the 4th pipe,
It mixes.The Noroxin aqueous solution of 5th pipe plus 2 mg/mL, the ketoconazole piece aqueous solution of the 6th pipe plus 1 mg/mL,
7th pipe plus sterile saline.40 DEG C of beef extract soup agar medium is cooled to after taking the heating of label sterilizing plates to melt
(Candida albicans sabouraud culture medium) 20 mL shake up, after to be solidified, with the aseptic card punch of 6 mm of diameter on culture medium
Uniformly punching (3~4 holes/ware), each hole is separately added into the medical fluid and physiological saline (0.2 of the above different quality containing prepared
The hole mL/), then cultured staphylococcus aureus, escherichia coli, Candida albicans are uniformly inoculated with to each hole four respectively
Week, 37 DEG C of 24 h of incubation are observed and are measured antibacterial circle diameter.It repeats twice of aforesaid operations, i.e., every pipe does 3 in parallel, finally
Antibacterial circle diameter takes the average value of three, and the results are shown in Table 3:
The In Vitro Bacteriostasis diameter result (mm) of 3 Chinese traditional medicine composition activity extract A of table
It was found from 3 experimental result of table: Chinese traditional medicine composition activity extract A reads staphylococcus aureus, escherichia coli and white
Pearl bacterium has obvious In Vitro Bacteriostasis.
Embodiment 7: irritant experiment of the Chinese traditional medicine composition activity extract A to rat mucous membrane of mouth
By the obtained Chinese traditional medicine composition activity extract A of embodiment 1, it is diluted to required concentration with sodium chloride injection, it is right
Rat mucous membrane of mouth carries out irritant experiment, irritative response of the observation multiple dosing to rat mucous membrane of mouth.Its experimental design,
Implementation Process and experimental result specifically:
20 rats are randomly divided into Chinese medicine group to be combined and 2 groups of Normal group, every group 10.Chinese medicine group is combined
2500 μ L/100g weights (30 times that are equivalent to clinical day for human beings dosage) are combined to Chinese medicine, the average mark 5 in 4 h
At the cheek mucous membrane of secondary instillation rat two sides.Normal group is without any processing.After 24 h are administered, medicine-feeding part hyperemia is observed and recorded
With oedema situation, and score;Observing animal, whether there is or not systemic adverse reactions.It is administered daily and observes, total 7d;Continue after drug withdrawal
Observe 7d.Mucous membrane is congested, oedema standards of grading are shown in Table shown in 4, table 5, the results are shown in Table 6；
The reaction of 4 irritation on mucous membrane of table and standards of grading
5 mucosa irritation intensity evaluation standard of table
Oral cavity mucosa irritation reacts mean scores n=10 after 6 each group multiple dosing of table
It was found from 6 experimental result of table: Chinese traditional medicine composition activity extract A is nonirritant to rat mucous membrane of mouth, is a safety
Chinese traditional medicine composition.
Embodiment 8: influence of the Chinese traditional medicine composition activity extract A to oral cavity ulcers curative effect and microbial flora
1. research object and screening principle
Using the 50 canker sore patients accepted for medical treatment during in April, -2019 in October, 2018 as research object, it is randomly divided into sight
Examine group and control group, every group 25.Wherein control group male 15, female 10；Age 27-58 years old, average age
(41.8 ± 15.4) year；The course of disease 20-47 days, average course of disease (31.2 ± 16.7) day.Chinese medicine combines male 13 in observation group
Example, female 12；Age 25-54 years old, average age (42.9 ± 13.2) year；The course of disease 23-50 days, average course of disease (32.1 ±
18.2) day.The general information of two groups of patients is comparable without significant difference (P > 0.05).(1) all patients meet " mouth
Transmucosal disease " canker sore diagnostic criteria person；(2) tcm diagnosis meets the Ministry of Public Health's " new Chinese medicine clinical research guidance original
Aphtha person in then "；(3) nearly 6 months unused Chinese medicine persons；(4) nearly 6 months unused hormone medicine persons；(5) it obtains
Patient and its family members' informed consent.
2 treatment methods
2.1 control group
It is smeared every other day using levamisol liniment (Fuzhou Chenxing Pharmaceutical Co., Ltd, national drug standard H20003344) once,
It 500mg/ times, is used in conjunction 2 weeks；VITAMIN C TABLET (Northeast Pharmaceutical Group Shenyang First Pharmaceutical Co., Ltd., national drug standard
H21022862 it) takes orally, 0.2g/ times, daily 3 times.(upper nine good fortune pharmaceutcal corporation, Ltd of Hisense's friendship, traditional Chinese medicines are quasi- for vitamin B 12
Word H31022370) it is oral, 10mg/ times, daily 3 times.
2.2 observation group
It is treated using Chinese traditional medicine composition side, medicinal extract dries, and is ground into a powder and is put into the plastic jar with spray head, gently sprays ulcer
The surface of a wound, 3 times/d, having sprayed not drink water or feed at least 1h after drug.
Curative effect is evaluated after two groups for the treatment of 14d.
3 treatment results
3.1 curative effect determinate standard
Recovery from illness: all clinical symptoms all disappear；Effective: ulcer wound surface healing, feeling of pain disappear；Effective: ulcer wound surface reduces
>=1/2, feeling of pain is unobvious；It is invalid: symptom ditto without improve or ulcer area reduce < 1/3, patient still can not be successfully into
Food.
3.2 observation index
It evaluates the curative effect of two groups of patients respectively before and after treatment, counts the ulcer duration.It is surveyed before and after treatment using PCR fluorescence art
Determine the quantity of two groups of patient's Streptococcus oralis, Neisseria and Wei Rong Salmonella.
3.3 result
3.3.1 two groups of patient's curative effects compare: being shown in Table 7.
7 two groups of curative effects of table compare (example)
* compared with the control group, P < 0.05.
3.3.2 two groups of patients compare the ulcer duration: being shown in Table 8.
8 two groups of ulcer duration of table compare (d, x ± s)
* compared with the control group, P < 0.05.
3.3.3 two groups of oral microorganism floras compare: being shown in Table 9.
9 two groups of oral microorganism floras of table compare (a, x ± s)
* with this group before treatment, P < 0.05；# is compared with after control group treatment, P < 0.05.
From the Germicidal efficacy of crowd, it is seen that Chinese traditional medicine composition activity extract A has relatively good effect to canker sore, performance
It is significantly improved in total effective ratio control to ulcer, and shortens the healing time of ulcer, promote the relevant beneficial bacterium of canker sore
Improve the unbalance situation of flora.
Embodiment 9: influence of the Chinese traditional medicine composition activity extract A to the alveolar bone of rats with experimental periodontitis
Select 48 tooth body dentures complete, no dental caries are gone bad and 5 week old SD rats of periodontosis, half male and half female, weight 200g ± 20g.
It is randomly divided into Normal group, model group, (positive treatment group, drug used are Chlorhexidine Compound Mouthrinse Solution, Jiangsu morning to mouth Thailand group
Board Bond pharmaceutcal corporation, Ltd, national drug standard H20058018), Chinese medicine composition A group (is according to dosage divided into low middle high group): combination
Object A low dose group 0.5mg/kg, composition A middle dose group 1.5mg/kg, composition A high dose group 4.5mg/kg, every group 8 greatly
Mouse.Improved (Luo Lijun, Shu Rong, Li Chaolun, Xie Yufeng, Qiao Weiwei experimental animal model of periodontitis with Luo Lijun literature method
Establish [J] oral cavity material instrument magazine, 2005 (03): 120-122.).With one big tweezers opening, with ophthalmic curved scissors to two
Side tooth surrounding gum carries out scribing removing, then feeds the soft feed to be impregnated with 10% white sand syrup and hello white granulated sugar water,
Modeling terminates to use normal diet instead, and gives and treat, and every animal is each tested by instiling in 0.1ml/100g twice daily oral cavity
Drug, feeding and water again after fasting 4h after medication.Off-test take animal alveolar bone do pathology section examination alveolar bone situation (see
Attached drawing 1).
It was found from attached drawing 1: composition A obviously inhibits the absorption of the alveolar bone of experimental rat periodontitis.
Similarly, by embodiment 2,3 obtained Chinese traditional medicine composition activity extract B, C, according to reality described in embodiment 4-9
Proved recipe method is tested with experimental procedure, the results showed that experimental data is close with embodiment 4-9, experiment conclusion and implementation
Example 4-9 is consistent.
Specific embodiments of the present invention are described in detail above, but it is merely an example, the present invention is simultaneously unlimited
It is formed on above description specific embodiment.To those skilled in the art, the equivalent modifications and replace that any couple of present invention carries out
In generation, is also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by equal transformation and repair
Change, all covers within the scope of the present invention.
Claims (8)
1. it is a kind of for adjusting the Chinese traditional medicine composition of oral cavity flora, it is the direct mixture or activity extract of Chinese medicine material, spy
Sign is, the Chinese traditional medicine composition include: in terms of mass fraction 20-30 parts of HERBA ELSHOLTZIAE, 20-25 parts of Radix Astragali, 10-20 parts of Hang Ju,
5-10 parts of honeysuckle.
2. according to claim 1 for adjusting the Chinese traditional medicine composition of oral cavity flora, which is characterized in that the adjustment oral cavity
Flora are as follows: oral peculiar smell caused by eliminating because of oral cavity harmful bacteria, anti-treating dental ulcer alleviate periodontitis.
3. according to claim 1 for adjusting the Chinese traditional medicine composition of oral cavity flora, it is characterised in that: the Chinese traditional medicine composition
Direct mixture is used to prepare adjustment oral cavity flora, prevention and treatment oral peculiar smell, anti-treating dental ulcer or the medical system for alleviating periodontitis
Agent.
4. according to claim 1 for adjusting the Chinese traditional medicine composition of oral cavity flora, it is characterised in that: the Chinese traditional medicine composition
Activity extract is used to prepare medical preparation, medical articles, dietotherapy with adjustment oral cavity flora, improvement oral hygiene effect
Product, daily chemical products.
5. a kind of as described in claim 1 for adjusting the preparation of the Chinese traditional medicine composition activity extract of oral cavity flora, feature exists
In: the following steps are included: in S1, Chinese traditional medicine composition each Chinese medicine material crushing；S2, it is matched according to Chinese traditional medicine composition, it will be smashed
Each Chinese medicine material is uniformly mixed；S3, mixed Chinese medicine material is soaked in water；S4, Chinese medicine material decoct；S5, filter pan-fried
Boil filtrate；S6, the concentration for decocting filtrate；S7, sterilizing packing, store it is spare.
6. according to claim 5 for adjusting the preparation of the Chinese traditional medicine composition activity extract of oral cavity flora, feature exists
In: the time soaked in water described in step S3 is 0.5-2 h.
7. according to claim 5 for adjusting the preparation of the Chinese traditional medicine composition activity extract of oral cavity flora, feature exists
In: it is 2-3 times that Chinese medicine material described in step S4, which decocts, each 0.5-1h.
8. according to claim 5 for adjusting the preparation of the Chinese traditional medicine composition activity extract of oral cavity flora, feature exists
In: concentration described in step S6 is to be concentrated under reduced pressure under the conditions of vacuum < -0.08MPa.
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