CN101780172B - Bacteriostatic washing liquor with high bacteriostatic action and method for preparing same - Google Patents
Bacteriostatic washing liquor with high bacteriostatic action and method for preparing same Download PDFInfo
- Publication number
- CN101780172B CN101780172B CN201010133612XA CN201010133612A CN101780172B CN 101780172 B CN101780172 B CN 101780172B CN 201010133612X A CN201010133612X A CN 201010133612XA CN 201010133612 A CN201010133612 A CN 201010133612A CN 101780172 B CN101780172 B CN 101780172B
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- bacteriostatic
- washing liquor
- antibacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention provides bacteriostatic washing liquor with high bacteriostatic action and a method for preparing the same. The bacteriostatic washing liquor comprises the following raw materials in part by weight: 30 to 80 parts of lightyellow sophora root, 20 to 60 parts of amur corktree bark, 30 to 80 parts of Malan straw and 10 to 50 parts of climbing groundsel herb. The prescription medicament of the invention is characterized by widely available raw materials, proper price and simple production process; and the bacteriostatic washing liquor also has the advantages that: the bacteriostatic washing liquor is prepared by using toxin-free Chinese medicaments as main raw materials, so that the bacteriostatic washing liquor is toxin free and non-irritating, and does not cause any side effect; and the invention aims to provide a disinfection product with high bacteriostatic action, which is the external washing liquor having the advantages of good effect on bacterial infection, obvious curing effect, simple formula and proper price. The bacteriostatic washing liquor contains bacteriostatic components in natural Chinese herbal medicaments, and can be used for cleaning, bacteriostasis and removal of peculiar smell of male and female private parts, and can also be used for daily hygiene caring and nursing during puerperium, induced abortion and menstrual period and before and after sexual intercourse.
Description
Technical field
The present invention relates to a kind of bacteriostatic lotion and preparation method thereof, belong to external cleaning medicine (sterile products) technical field with strong bacteriostasis.
Background technology
Other positions of human body reproductive organ and human body are different, and are more special, relatively more fragile; Easily by bacterial infection, women particularly, its physiological feature is comparatively special; Anus, vagina, three important openings of urethra are more concentrated; And discharge different material separately, do not notice that slightly cleaning will be infected breeding by antibacterial, virus, mycoplasma, chlamydia, infusorian etc., causes a series of malaise symptoms.If this type symptom can not get handling or dealing with improperly, have in addition can cause malignant change.It is main washing liquid that existing human body reproductive organ abluent has with the western medicine composition, and Western medicine class washing liquid is often through eliminating the pathogenic microorganism in genitals's environment, to reach the purpose of sterilizing.With metronidazole, chlorhexidine etc. is representative, and sterilizing ability is strong, but zest is to a certain degree all arranged; Can produce the zest influence to the genitals; Destroy easily the pH environment of human body reproductive organ, and the sense of the dry discomfort of skin is arranged after using, sometimes even cause serious allergy.Simultaneously because antibiotic long-term, a large amount of use is prone to make the human obstinate drug resistance that forms, reusing curative effect and will descend significantly this quasi drugs.
Summary of the invention
The technical problem that the present invention will solve provides a kind of strong bacteriostasis that has, evident in efficacy, do not contain antibiotic, do not destroy human body reproductive organ PH environment, to non-stimulated bacteriostatic lotion of human body and preparation method thereof with strong bacteriostasis.
Technical scheme of the present invention is: a kind of bacteriostatic lotion with strong bacteriostasis, and it comprises the following weight proportion raw material:
30～80 parts of Radix Sophorae Flavescentiss, 20～60 parts of Cortex Phellodendris, 20～60 parts of Herba Taraxacis, 30～80 parts of Herba Kalimeridis grasss, 10～50 parts of Herba Senecionis Scandentiss.
It comprises the following weight proportion raw material:
40～70 parts of Radix Sophorae Flavescentiss, 30～50 parts of Cortex Phellodendris, 30～50 parts of Herba Taraxacis, 40～70 parts of Herba Kalimeridis grasss, 20～40 parts of Herba Senecionis Scandentiss.
It is to be made up of the following weight proportion raw material:
50 parts of Radix Sophorae Flavescentiss, 40 parts of Cortex Phellodendris, 30 parts of Herba Taraxacis, 60 parts of Herba Kalimeridis grasss, 20 parts of Herba Senecionis Scandentiss, antibacterial are an amount of.
Described bacteriostatic lotion is lotion, gel or membrane.
Method for preparing with bacteriostatic lotion of strong bacteriostasis be get Radix Sophorae Flavescentis earlier, Cortex Phellodendri is soaked to passing through the heart, again with Herba Taraxaci, Herba Kalimeridis grass, Herba Senecionis Scandentis three flavor medical materials, decocte with water; Filter; Filtrating concentrates, and the adding antibacterial is an amount of, adds water and is adjusted to ormal weight; Mixing gets washing liquid, and then adopts conventional method to process lotion, gel or membrane.。
Aforesaid method for preparing with bacteriostatic lotion of strong bacteriostasis is that the decocte with water number of times is 3 times, and will decoct the merging of gained filtrating at every turn.
The method for preparing of the above-mentioned bacteriostatic lotion with strong bacteriostasis is the 1st decoction 2 hours, the 2nd decoction 1.5 hours, the 3rd decoction 1 hour.
The method for preparing of the above-mentioned bacteriostatic lotion with strong bacteriostasis is that filtrating is concentrated into relative density 1.01～1.02.
Above-mentioned method for preparing with bacteriostatic lotion of strong bacteriostasis is, used antibacterial is that Tallofin (Tai Lefen), hibitane, amino sting pyridine, the phenol tribute of vinegar zinc or benzalkonium bromide.
Above-mentioned method for preparing with bacteriostatic lotion of strong bacteriostasis is, described ormal weight is adjusted to 1000ml in every part of recipe quantity Pharmaceutical, adding water, and wherein the unit of raw material is g in every part of recipe quantity; The content of antibacterial is bacteriostatic agent 0.1%～0.5% in every 1000ml washing liquid.
Compare with prior art: the present invention selects these article of selecting from numerous antiinflammatory, detoxifcation Chinese medicine medicine basis side; And the basic side who chooses is the medicine that can directly use, not have any toxin; Its basis side is made up of Chinese medicine of the five flavours such as Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Herba Kalimeridis grass, Herba Senecionis Scandentiss, wherein:
Radix Sophorae Flavescentis:
Dry root for leguminous plant Radix Sophorae Flavescentis Sophora flavescens Ait..Function cures mainly: heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Be applied to: 1, pudendal pruritus under the treatment belt: to women's leucorrhea with yellow discharge, and male's swelling of the vulva pudendal pruritus all has good therapeutical effect.2, treatment eczema scabies: Radix Sophorae Flavescentis is bathed can remove damp-heat in lower-JIAO, and killing parasites for relieving itching, and the skin pruritus that the eczema scabies is caused has good mitigation.3, treatment dysuria: Radix Sophorae Flavescentis is bathed can treat the dysuria that a variety of causes causes, scorching hot puckery pain.Especially the dysuria that the women is caused because of gestation cooperates and takes Radix Sophorae Flavescentis decoction effect more.
Cortex Phellodendri:
These article are the dry bark of rutaceae wampee Phellodendron chinense Schneid..Function cures mainly: heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency.Pharmacological action: 1. antibacterial action; 2. antifungic action; 3. anti-trichomonal effect etc.
Herba Taraxaci: these article are the dry herb of feverfew Herba Taraxaci Taraxacum mongolicum Hand-Mazz..Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.Be used for furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Pharmacological action: 1. antibacterial action; 2. antifungic action; 3. antitumor action etc.
Herba Senecionis Scandentis:
These article are feverfew Herba Senecionis Scandentis Senecio scandens Buch, the fresh or dry aerial parts of-Ham..Function cures mainly: heat clearing away is alleviated pain, improving acuity of vision and removing nebula, killing parasites for relieving itching.Be used for influenza, upper respiratory tract infection, pneumonia, acute tonsillitis, parotitis, acute enteritis, trichomonal vaginitis, jaundice, cholecystitis, bacillary dysentery, acute urinary tract infection, conjunctival congestion and swelling pain, carbuncle furunculosis, erysipelas, eczema, dried exudative dermatitis skin ulcer, burn and scald.Pharmacological action: 1. antibacterial action; 2. anti-spirillum effect etc.
Herba Kalimeridis grass:
These article are the dry herb of feverfew Herba Kalimeridis Kalimeris indica (L.) Sch.-Bib.Herba Kalimeridis grass Miao ethnic group medicine name: Mas lanx Band Herba Kalimeridis pill (Guizhou pine peach); Ghab jongx vob nail lies loud, high-pitched sound Gong Ah Nei slips (the Guizhou Province southeast); The Uab duat gheib frog fall this (the south of Guizhou Province, Guizhou); Gaok gend original text stalk (Guizhou Bijie).Function cures mainly to regulate the flow of vital energy and helps digestion, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Be used for the gastral cavilty distending pain, jaundice, cold cough, sore throat, wound hemorrhage, edema, stranguria with turbid discharge, hemorrhoid.The main effective ingredient of Herba Kalimeridis grass is a cupreol, and cupreol is one type of material with physiologically active, can be used for effects such as antiinflammatory, antitumor and adjusting immunity.
Selected above-mentioned Chinese medicine of the five flavours all has the merit that the furunculosis acute mastitis is itched, treated in heat clearing away, detoxifcation, dampness, eliminating carbuncleization.The effect of the red anal fistula of treatment anus, skin ulcer, urinary tract infection is arranged, the seminal emission nebulousurine is also had certain effect.But above-mentioned Chinese medicine of the five flavours is not simple combination, is coming after the applicant conscientiously screens through a large amount of experiments with after testing, and is embodied in:
Pudendum and vagina through under the medical science test health status all are tart environment, and pH value is about about 4, and intravaginal has many lactobacilluss keeping the health of vaginal environment; Number is all seldom under normal condition for other antibacterial, mycete; If external interference is arranged, possibly will cause the pathogenic bacteria hypertrophy to infect, pudendum and intravaginal pH-value are changed; So only be acid in external antiinflammatory washing liquid, and in use pH value 4 washing liquid could be better, the more permanent curative effect that reaches.
And this washing liquid stock solution pH value is 3.92, during use after 10 times of dilutions the pH value of diluent be 4.05, approaching with the vaginal health environment.And the pH value of these article is getting of making after being in harmonious proportion each other through the pure natural plant medicament, and no any additives can not bring sense of discomfort to human body skin.Used prescription drugs all has the characteristics that raw material sources are extensive, moderate, production technology is easy, and the present invention simultaneously also has the following advantages:
1. to adopt nontoxic Chinese medicine be that primary raw material is processed in the present invention, nontoxic non-stimulated, has no side effect;
2. the purpose of this invention is to provide a kind of sterile products, to the external wash liquid that bacterial infection is with strong points, evident in efficacy, prescription is uncomplicated, moderate with strong bacteriostasis.These article contain the natural Chinese medicinal herb antipathogenic composition, can be used for male and female pudendum cleaning, antibacterial, eliminate the unusual smell, also can be used for the daily hygiene health care before and after puerperal, artificial abortion, menstrual period, sexual life, nursing.These article of experiment proof can effectively suppress pathogenic microbial pudendum infection such as staphylococcus aureus, escherichia coli, Candida albicans, skin infection, and bacteriostasis rate reaches 100%, and clinical trial certificate treatment total effective rate reaches more than 95%;
3. can stop bacterial cross-infection in the use well.
In order to verify that medicine of the present invention has excellent curative, and human body is had no adverse reaction, the applicant has carried out series of experimental research, and is specific as follows:
One, acute oral toxicity test
Material and animal:
1, given the test agent: lotion of the present invention, brown liquid.
2, experimental animal: 20 of Kunming kind secondary white mice, male and female half and half, body weight 18-22 gram.Your doctor's Experimental Animal Center provides: SCXK (Guizhou Province) 2002-0001.Laboratory animal occupancy permit: SYXK (Guizhou Province) 2008-0012.Temperature 21-24 ℃, humidity 46-52%.
Method:
1, detects foundation: disinfection technology standard (2002) 2.3.1 acute oral toxicity test.
2, assay method: take by weighing sample 5.0 grams, the adding distil water mixing is settled to 20ml, and a per os is given and tried thing in 24 hours.Irritating the stomach amount is 0.02ml/gBW, is 5000mg/kgBW.Observed 14 days.
Result of the test: in 14 days that observe, do not find that poisoning symptom and death appear in laboratory animal, after the off-test, the no abnormal change of anatomy experiment animal.
Acute oral toxicity test
Male and female its mouse oral LD
50>5000mg/kgBW
Conclusion: lotion of the present invention is to experiment mice acute oral toxicity test median lethal dose(LD 50) LD
50>5000mg/kgBW, the true border of toxicity grading is nontoxic.
Two, vaginal mucosa irritation property test
Material and animal:
1, given the test agent: washing liquid of the present invention, brown liquid, proportion: 1.00.
2, animal and environment: the healthy female New Zealand white rabbits of just growing up, your doctor's Experimental Animal Center provides: SCXK (Guizhou Province) 2002-0001.Laboratory animal occupancy permit: SYXK (Guizhou Province) 2008-0012.18 ℃ of temperature, humidity 60%.
Method:
1, detects foundation: Ministry of Public Health " disinfection technology standard " (version in 2002) 2.3.5 vaginal mucomembranous irritant test.
2, assay method: sample mix is even, directly draw stock solution and contaminate.It is fixing that animal is faced upward, and exposes perineum and vaginal orifice.With length is that blunt nosed flexible pipe about 8 ㎝ is connected with the syringe of 2ml; Inject 2ml and tried thing, conduit with softly inserting vagina (4 ㎝-5 ㎝) after receiving test solution moistening, and is slowly injected 2ml with syringe and tried thing (every animal each overlap with); Extract conduit out, accomplish contamination.Matched group is done same the processing with normal saline.So read back 24h, adopt the aeroembolism method to put to death animal, cut open the belly and take out complete vagina; Vertically cut; Whether perusal has hyperemia, edema etc., then vagina is put into 10% formalin solution fixedly more than the 24h, choose vagina 3 positions in two ends and central authorities organize film-making; Histopathological examination is carried out in HE dyeing.
Result of the test:
Experimental group, each three zootomy vagina perusal no abnormality seen of matched group; Pathologic finding: each three animal vagina of experimental group, matched group all have small quantities of leukocytes to soak into and hyperemia and edema in various degree, and 1, No. 3 animal vagina upper, middle and lower of experimental group section epithelial tissue has slight cytopathy, tissue rotten to the corn; 1, No. 2 animal vagina upper, middle and lower of matched group section epithelial tissue has slight cytopathy, tissue erosion.
Washing liquid vaginal mucosa irritation reaction scoring of the present invention
Annotate: in the scoring hurdle, the IR scoring is three positions of every animal vagina IR scoring sum.
Conclusion:
Washing liquid of the present invention is 2.40 to each item SI of laboratory animal vaginal mucosa, and stimulus intensity is classified as utmost point subexcite.
Three, skin allergic reaction test
Material and animal:
1, given the test agent: washing liquid of the present invention, brown liquid, proportion: 1.00.
2, animal and environment: the albino guinea-pig that healthy skin is intact, your doctor's Experimental Animal Center provides: SCXK (Guizhou Province) 2002-0001.Laboratory animal occupancy permit: SYXK (Guizhou Province) 2008-0012.Temperature 18-20 ℃, humidity 48-68%.
Method:
1, detects foundation: the test of Ministry of Public Health " disinfection technology standard " version 2.3.6 in 2002 skin allergic reaction.
2, test method: experiment divides three groups, every group of 16 Cavia porcelluss.
(1) tried the thing group: 24h is with QUMAO in the 3 ㎝ * 3 ㎝ scopes of guinea pig back left side before the experiment, and sample thief stock solution 0.5ml drips on 2 layers of gauze of 2 ㎝ * 2 ㎝, with its QUMAO district in the left side of applying ointment or plaster.Cover with one deck cellophane, fix with non-stimulated step, what continue will apply ointment or plaster behind the 6h is tried the thing flush away.Testing 7d and 14d in kind repeats once.Induce back 14d at last, sample stock solution 0.5ml is dripped on 2 layers of gauze of 2 ㎝ * 2 ㎝,, cover and non-stimulated immobilization with adhesive tape with one deck cellophane then its 3 ㎝ that apply ointment or plaster on the guinea pig back right side * 3 ㎝ QUMAO districts.What continue will to apply ointment or plaster behind the 6h is tried the thing flush away.Observe dermoreaction behind 24h and the 48h.
(2) positive controls: the same experimental group of experimental technique, inducer are 2, the 4-dinitrochlorobenzene, and induced concentration 4% excites concentration 1.2%.
(3) negative control group: do not induce stimulation, only excite contact to be tried thing latter stage in experiment.
Result of the test:
Washing liquid of the present invention is to guinea pig skin allergy result
Annotate: skin erythema response strength and edema response strength, being at the dermoreaction integration is the number of animals under 0,1,2,3,4 the condition.
Conclusion:
Washing liquid of the present invention is 0% to guinea pig skin sensitization rate, by " disinfection technology standard " version 2.3.6.5 in 2002 bar standard evaluation, does not see skin allergic reaction.Positive controls sensitization rate 87.5% belongs to pole strength sensitization, and negative control group is not seen skin allergic reaction.
Four, PCEMNR micronucleus test
Material and animal:
1, given the test agent: washing liquid of the present invention, brown liquid.
2, animal and environment: 50 of Kunming kind secondary mices, male and female half and half, body weight 25-30 gram.Your doctor's Experimental Animal Center provides: SCXK (Guizhou Province) 2002-0001.Laboratory animal environment occupancy permit: SYXK (Guizhou Province) 2008-0012.Temperature 23-24 ℃, humidity 48-50%.
Method:
1, detects foundation: Ministry of Public Health " disinfection technology standard " (2002) 2.3.8.4 PCEMNR micronucleus test.
2, test is divided into groups and method: take by weighing and tried thing 10g, 5g, 2g and be settled to 40ml respectively with distilled water; Be equivalent to 5000mg/kgBW, 2500mg/kgBW, three dosage of 1000mg/kgBW; Distilled water is made as matched group, and cyclophosphamide 50mg/kgBW is made as positive controls.Select 50 of Kunming kind secondary mices for use, be divided into 5 groups at random, 10 every group, male and female half and half; At interval irritate stomach 24 hours twice, irritating the stomach amount is 0.02mg/kgBW, irritate stomach for the second time after cervical vertebra dislocation in 6 hours put to death animal; Get bone marrow of sternum and dilute smear with calf serum, methanol is fixed, Giemsa dyeing.Every animal oil mirror is counted 1000 polychromatic erythrocytes (PCE) down, observes the PCE that contains micronucleus, and micronuclear rates is represented with permillage.Count observed mature erythrocyte (NCE) number when wherein counting 200 PCE, and calculate the ratio (PCE/NCE) of polychromatic erythrocyte and mature erythrocyte.
Result of the test: ordinary circumstance was good after laboratory animal was irritated stomach, abnormal response do not occur.
Washing liquid mouse bone marrow cells micronucleus cell result of the test of the present invention
* compare with negative control group (P 0.01)
The result shows: each dose groups of washing liquid of the present invention and negative control group are relatively analyzed through the sided t inspection statistics, and difference that there are no significant (P>0.05), negative control group and positive controls relatively have significant difference (P < 0.01).The ratio of each dose groups and yin and yang attribute matched group polychromatic erythrocyte and mature erythrocyte (PCE/NCE) is all in range of normal value.
So in this test dose scope, washing liquid of the present invention is negative to PCEMNR micronucleus test result.
Five: physical and chemical inspection
Test basis:
Ministry of Public Health " disinfection technology standard " version 2.2.1.4 in 2002
Detect conclusion:
Show that through measuring washing liquid stock solution pH value of the present invention is that 3.92,10 times of diluent pH value are 4.05.
The specific embodiment:
Embodiment 1:
It is an amount of to get Radix Sophorae Flavescentis 30kg, Cortex Phellodendri 20kg, Herba Taraxaci 20kg, Herba Kalimeridis grass 30kg, Herba Senecionis Scandentis 10kg, antibacterial.
Its production method:
Get Radix Sophorae Flavescentis 30kg, Cortex Phellodendri 20kg earlier and soak, again with Herba Taraxaci 30kg, Herba Kalimeridis grass 30kg, Herba Senecionis Scandentis 10kg three flavor medical materials, decocte with water three times to passing through the heart; Decocted 2 hours the 2nd decoction 1.5 hours, the 3rd decoction 1 hour for the 1st time; Filter, merge filtrating three times, filtrating is concentrated into relative density 1.01～1.02; It is an amount of to add antibacterial, adds water and is adjusted to 1000L, mixing; Wherein the content of antibacterial is to add 1%～5% behind the water, and used antibacterial is that Tallofin (Tai Lefen), hibitane, amino sting pyridine, the phenol tribute of vinegar zinc or benzalkonium bromide, preferred benzalkonium bromide.Can adopt existing routine techniques that this washing liquid is processed into lotion, gel or membrane then.
Embodiment 2:
Radix Sophorae Flavescentis 80kg, Cortex Phellodendri 60kg, Herba Taraxaci 60kg, Herba Chlorophyti 80kg, Herba Senecionis Scandentis 50kg
Its production method:
Get Radix Sophorae Flavescentis 80kg, Cortex Phellodendri 60kg earlier and soak, again with Herba Taraxaci 60kg, Herba Kalimeridis grass 80kg, Herba Senecionis Scandentis 50kg three flavor medical materials, decocte with water three times to passing through the heart; Decocted 2 hours the 2nd decoction 1.5 hours, the 3rd decoction 1 hour for the 1st time; Filter, merge filtrating three times, filtrating is concentrated into relative density 1.01～1.02; Add water and be adjusted to 1000L, mixing; Can adopt existing routine techniques that this washing liquid is processed into lotion, gel or membrane then.
Embodiment 3:
Radix Sophorae Flavescentis 40kg, Cortex Phellodendri 30kg, Herba Taraxaci 30kg, Herba Kalimeridis grass 40kg, Herba Senecionis Scandentis 20kg
Its production method:
Get Radix Sophorae Flavescentis 40kg, Cortex Phellodendri 30kg earlier and soak, again with Herba Taraxaci 30kg, Herba Kalimeridis grass 40kg, Herba Senecionis Scandentis 20kg three flavor medical materials, decocte with water three times to passing through the heart; Decocted 2 hours the 2nd decoction 1.5 hours, the 3rd decoction 1 hour for the 1st time; Filter, merge filtrating three times, filtrating is concentrated into relative density 1.01～1.02; It is an amount of to add antibacterial, adds water and is adjusted to 1000L, mixing; Wherein the content of antibacterial is to add 1%～5% behind the water, and used antibacterial is that Tallofin (Tai Lefen), hibitane, amino sting pyridine, the phenol tribute of vinegar zinc or benzalkonium bromide, preferred benzalkonium bromide.Can adopt existing routine techniques that this washing liquid is processed into lotion, gel or membrane then.
Embodiment 4:
Radix Sophorae Flavescentis 70kg, Cortex Phellodendri 50kg, Herba Taraxaci 50kg, Herba Kalimeridis grass 70kg, Herba Senecionis Scandentis 40kg
Its production method:
Get Radix Sophorae Flavescentis 70kg, Cortex Phellodendri 50kg earlier and soak to passing through the heart, with Herba Taraxaci 50kg, Herba Kalimeridis grass 70kg, Herba Senecionis Scandentis 40kg three flavor medical materials, decocte with water filters again, and filtrating concentrates, and it is an amount of to add antibacterial, adds water and is adjusted to ormal weight, mixing.Conventional method according to this area is processed finished product.
Embodiment 5:
Radix Sophorae Flavescentis 50kg, Cortex Phellodendri 40kg, Herba Taraxaci 30kg, Herba Kalimeridis grass 60kg, Herba Senecionis Scandentis 20kg
Its production method:
Get Radix Sophorae Flavescentis 50kg, Cortex Phellodendri 40kg earlier and soak, again with Herba Taraxaci 30kg, Herba Kalimeridis grass 60kg, Herba Senecionis Scandentis 20kg three flavor medical materials, decocte with water three times to passing through the heart; Decocted 2 hours the 2nd decoction 1.5 hours, the 3rd decoction 1 hour for the 1st time; Filter, merge filtrating three times, filtrating is concentrated into relative density 1.01～1.02; It is an amount of to add antibacterial, adds water and is adjusted to 1000L, mixing; Wherein the content of antibacterial is to add 1%～5% behind the water, and used antibacterial is that Tallofin (Tai Lefen), hibitane, amino sting pyridine, the phenol tribute of vinegar zinc or benzalkonium bromide, preferred benzalkonium bromide.Can adopt existing routine techniques that this washing liquid is processed into lotion, gel or membrane then.
Method for using:
External, the time spent shakes up.These article of getting are an amount of, and 5～10 times of amount dilutions of boiled water back of heating is cleaned or demibain.
Claims (6)
1. inhibiting-bacteria preparation with bacteriostasis, it is characterized in that: it is to be processed by the following weight proportion raw material:
30～80 parts of Radix Sophorae Flavescentiss, 20～60 parts of Cortex Phellodendris, 20～60 parts of Herba Taraxacis, 30～80 parts of Herba Kalimeridis grasss, 10～50 parts of Herba Senecionis Scandentiss, antibacterial are an amount of, its preparation method be get Radix Sophorae Flavescentis earlier, Cortex Phellodendri is soaked to passing through the heart, again with Herba Taraxaci, Herba Kalimeridis grass, Herba Senecionis Scandentis three flavor medical materials; Decocte with water; Filter, filtrating concentrates, and the adding antibacterial is an amount of; Add water and be adjusted to ormal weight, mixing gets washing liquid; And then adopt conventional method to process lotion, gel or membrane; Ormal weight is adjusted to 1000ml in every part of recipe quantity medicinal liquid, adding water, and wherein the unit of raw material is g in every part of recipe quantity; The content of antibacterial is bacteriostatic agent 0.1%～0.5% in every 1000ml washing liquid; Used antibacterial is that Tai Lefen, hibitane, amino sting pyridine or benzalkonium bromide.
2. the inhibiting-bacteria preparation with bacteriostasis according to claim 1 is characterized in that: it is to be processed by the following weight proportion raw material:
40～70 parts of Radix Sophorae Flavescentiss, 30～50 parts of Cortex Phellodendris, 30～50 parts of Herba Taraxacis, 40～70 parts of Herba Kalimeridis grasss, 20～40 parts of Herba Senecionis Scandentiss, antibacterial are an amount of.
3. the inhibiting-bacteria preparation with bacteriostasis according to claim 1 and 2 is characterized in that: it is to be processed by the following weight proportion raw material:
50 parts of Radix Sophorae Flavescentiss, 40 parts of Cortex Phellodendris, 30 parts of Herba Taraxacis, 60 parts of Herba Kalimeridis grasss, 20 parts of Herba Senecionis Scandentiss, antibacterial are an amount of.
4. the inhibiting-bacteria preparation with bacteriostasis according to claim 3 is characterized in that: the decocte with water number of times is 3 times, and will decoct the merging of gained filtrating at every turn.
5. according to the described inhibiting-bacteria preparation of claim 4, it is characterized in that: the 1st decoction 2 hours, the 2nd decoction 1.5 hours, the 3rd decoction 1 hour with bacteriostasis.
6. the inhibiting-bacteria preparation with bacteriostasis according to claim 3 is characterized in that: filtrating is concentrated into relative density 1.01～1.02.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010133612XA CN101780172B (en) | 2010-03-29 | 2010-03-29 | Bacteriostatic washing liquor with high bacteriostatic action and method for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010133612XA CN101780172B (en) | 2010-03-29 | 2010-03-29 | Bacteriostatic washing liquor with high bacteriostatic action and method for preparing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101780172A CN101780172A (en) | 2010-07-21 |
| CN101780172B true CN101780172B (en) | 2012-08-29 |
Family
ID=42520396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010133612XA Active CN101780172B (en) | 2010-03-29 | 2010-03-29 | Bacteriostatic washing liquor with high bacteriostatic action and method for preparing same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101780172B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105116081A (en) * | 2015-04-20 | 2015-12-02 | 贵阳德昌祥药业有限公司 | Detection method for heat-clearing and stasis-removing drugs |
| CN106943454A (en) * | 2017-03-30 | 2017-07-14 | 黑龙江童医生儿童生物制药有限公司 | A kind of disposable antibacterial spraying of plant type and preparation method thereof |
| CN112402507A (en) * | 2020-11-20 | 2021-02-26 | 山东禹迪医疗科技有限公司 | Traditional Chinese medicine gel cleaning agent and preparation method thereof |
| CN113274442A (en) * | 2021-01-18 | 2021-08-20 | 安徽绿阳生物科技有限公司 | Preparation method of herbal skin bacteriostatic agent |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047943C (en) * | 1993-01-12 | 2000-01-05 | 徐德芬 | Traditional Chinese medicine preparation |
| CN1116047A (en) * | 1994-08-03 | 1996-02-07 | 柳州柳瑞旅游保健卫生制品厂 | Solution for disinfection |
| CN1174765C (en) * | 2001-07-23 | 2004-11-10 | 陈佩云 | Composite Chinese medicine for treating venereal disease and dermatosis and its prepn. |
-
2010
- 2010-03-29 CN CN201010133612XA patent/CN101780172B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101780172A (en) | 2010-07-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JU et al. | Indigenous knowledge on medicinal plants used by ethnic communities of South India | |
| al-Mamun et al. | Brine shrimp toxicity study of different Bangladeshi medicinal plants | |
| CN110464811A (en) | A kind of gynaecology's foam antibacterial liquid and preparation method thereof | |
| CN107802825A (en) | A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa | |
| Guarino et al. | Ethnobotanical study of the Sannio area, Campania, southern Italy | |
| CN113081928B (en) | Plant antibacterial gel and preparation method and application thereof | |
| CN1679888A (en) | Decoction Chinese medicine sterilizing antiphlogistic, preparation and use thereof | |
| CN103316262B (en) | A kind of gynecological external antibacterial liquid and preparation method thereof | |
| CN101780172B (en) | Bacteriostatic washing liquor with high bacteriostatic action and method for preparing same | |
| CN103432287A (en) | Tea seed foot bath powder and preparation method thereof | |
| CN105662996A (en) | Traditional Chinese medicine mask for treating menstruation-associated acne | |
| CN104258347A (en) | Sterilizing and inflammation-diminishing liquid for clinical laboratory | |
| CN103735845A (en) | Traditional Chinese medicine external preparation for treating pediatric secretory otitis media and preparation method thereof | |
| CN113546142A (en) | Propolis bacteriostatic gel and preparation method thereof | |
| CN103721138B (en) | A kind of traditional Chinese medicine for external application and its preparation method treating rosacea | |
| CN109602813A (en) | A kind of bacteriostatic gel and preparation method thereof | |
| CN104706953A (en) | Traditional Chinese medicine preparation for treating chronic cervicitis | |
| CN104645117A (en) | Traditional Chinese medicine disinfectant for clinical laboratory | |
| CN113785847A (en) | A fumigant with effects of eliminating dampness, removing toxic substance and avoiding plague, and its preparation method | |
| CN103599437B (en) | One treats colpitic traditional Chinese medicine liquid | |
| CN106266376A (en) | A kind of Chinese medicine composition for treating staphylococcus aureus | |
| CN106880698A (en) | A kind of plants essential oil and preparation method for treating child's property vaginitis | |
| CN105560763A (en) | Traditional Chinese medicine composition skin disinfectant | |
| CN105497460A (en) | Disinfectant for disinfecting skins | |
| KR101125758B1 (en) | A detergent composition for cleaning the women's genital area |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Bacteriostatic washing liquor with high bacteriostatic action and method for preparing same Effective date of registration: 20200108 Granted publication date: 20120829 Pledgee: Guizhou mingdekang Technology Center (L.P.) Pledgor: Guiyang Dechangxiang Pharmaceutical Co.,Ltd. Registration number: Y2020520000002 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220429 Granted publication date: 20120829 Pledgee: Guizhou mingdekang Technology Center (L.P.) Pledgor: Guiyang Dechangxiang Pharmaceutical Co.,Ltd. Registration number: Y2020520000002 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 550001 Sixth Floor, West Building, No. 2 Yan'an West Road, Guiyang City, Guizhou Province Patentee after: Guizhou Dechangxiang Pharmaceutical Co.,Ltd. Address before: 550001 Sixth Floor, West Building, No. 2 Yan'an West Road, Guiyang City, Guizhou Province Patentee before: Guiyang Dechangxiang Pharmaceutical Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |