CN106943454A - A kind of disposable antibacterial spraying of plant type and preparation method thereof - Google Patents
A kind of disposable antibacterial spraying of plant type and preparation method thereof Download PDFInfo
- Publication number
- CN106943454A CN106943454A CN201710203236.9A CN201710203236A CN106943454A CN 106943454 A CN106943454 A CN 106943454A CN 201710203236 A CN201710203236 A CN 201710203236A CN 106943454 A CN106943454 A CN 106943454A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- plant type
- grams
- compound chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
It is to include the aqueous solution of following raw material the invention discloses a kind of disposable antibacterial spraying of plant type：10 20 parts of compound Chinese medicinal material extracts, 0.05 0.2 parts of benzalkonium chlorides；The compound Chinese medicinal material extract is made up of the raw material of following parts by weight：24 parts of Flos Chrysanthemi Indici extract, 24 parts of Honegsukle flower P.E, 12 parts of dandelion extract, 0.09 0.2 parts of Baical Skullcap root P.E, 0.06 0.2 parts of licorice.The beneficial effects of the invention are as follows：Plant compound prescription, attenuation synergistic, not spirituosity.Formula is neutral, gentle, meets the requirement of child skin comfort level, with rear skin is moist, use in winter is not chapped.Non-water washing, rapid-curing cutback, nontoxic, non-stimulated, efficient sterilizing are antiviral.It is adapted to infant (neonate) and child skin sterilization, neonatal umbilical cord sterilization；It is also applied for handwashing disinfection, surgical incision sterilization, traumatic surface sterilization, the sterilization of perineum mucous membrane etc. before alcohol intolerance person use, operation and injection site sterilization, surgery.
Description
Technical field
The invention belongs to disinfectant field, and in particular to a kind of disposable antibacterial spraying of plant type and preparation method thereof.
Background technology
Pathogenic microorganism and Virus entry human body, which can cause, topically or systemically to be infected, especially old man, children, have chronic
Disease or immunologic hypofunction person, treat and not in time and have complications, can develop into septicemia or septicopyemia, it is most with
Serious pneumonia, a variety of organ failures such as the severe patient heart, kidney etc. cause death.Pathogenic microorganism and virus can by alimentary canal,
The number of ways such as respiratory tract, skin injury and mucous membrane are propagated, but as long as paying attention to sanitation and hygiene, keeping hand clean, you can prevent
Infection.Bleaching powder handwashing disinfection is used early in Austrian Semmelweis doctor before more than 100 years, makes the dead of hospital's puerperal fever at that time
The rate of dying is greatly reduced, so as to save the life of " millions of people.Now, by resisting " SARS " and " bird flu ", people are abundant
Recognize the importance of hand-wrist bones, sterilize increasingly universal.In the infectious process of disease, hand is that propagation microorganism is of crucial importance
Link and by way of the particularly special population such as children factor of hand in infectious diseases is more prominent.For body resistance
The low person of power, the autoinfection of human normal flora is generally also directly or indirectly to propagate caused by hand.
The use of hand disinfectant can be allowed to not constitute other people propagation by the bacterial control on skin in certain scope
The danger of disease, can also protect personal from infection；The sterilization of medical personnel's hand, can effectively reduce the generation of inside-hospital infection
Rate.Conventional disinfectant mainly has Peracetic acid, lysol, 84 thimerosals, Chlorhexidine, iodine eka iodine and its compound, high violent acid
Potassium, aldehydes, phenols, quaternary ammonium salt, chlorine-containing disinfectant, alcohols etc..Currently used for hand disinfectant sterilization component mainly have iodine class,
Alcohols, the stupid ether (DP300) of trichlorine hydroxyl two, guanidine and its compound preparation.Ethanol is that, using skin antiseptic for a long time, have preferably
Bactericidal effect and quick-drying.Also have in recent years and be re-dubbed production of the compound preparation for hand-wrist bones using ethanol and low effect disinfectants
Product are put on sale.Such as ethanol and Chlorhexidine, ethanol and the stupid ether (DP300) of trichlorine hydroxyl two, ethanol and isopropanol compound hand disinfectant
Product.It is mainly used in hospital surgery hand-wrist bones, health hand-wrist bones, skin, mucous membrane etc. sterilizes purposes.
Children and special population missing the healthy prevention consciousness, and bear a pretty, delicate skin, barrier action it is weaker, passive protective physical fitness is not
By force, Chang Yi is infected by pathogenic bacteria or virus, causes infectious diseases, such as influenza, brothers mouthful virus etc..Therefore, strengthen hand to disappear
Poison, is the effective measures of pre- bacteriological protection, disease of viral infection.The selection of disinfectant is most important during hand-wrist bones, sterilization
The species of agent is various, and some products have certain toxicity and excitant to human body.Hand sanitizer based on alcohol is intended to help
Child is protected from the pollution of bacterium, but when child misapplies them, disinfectant may be damaged to children.According to report
Road, hand disinfectant, which has, causes children's eye irritation, vomiting, or even a small number of children's intake disinfectants cause the case of stupor.Mostly
Have including symptoms such as Ocular irritation, vomiting, stomachache and coughs.According to CDC of the U.S. (CDC) report, from
2011 to 2014, swallow because of the children of less than 12 years old, suck or disinfectant will be hand-washed do the alarms more than 70,000 times of eyes.
Wherein 5 children fall into a coma, and 3 cause epileptic attack.Other serious health effects including two children occur hypoglycemia,
There is respiratory rate reduction or even stopped in two children.
In the market is seldom for the safety-type disposable bacteriostatic agent of children special-purpose, the current existing sterile products containing chemical composition
In the adverse reaction such as different degrees of presence skin irritation, allergic reaction.For a long time, it is a large amount of using to skin and healthy making
Into certain injury, there is serious potential safety hazard.Therefore, designing the disposable antibacterial spraying of a children special-purpose is extremely necessary,
While ensureing that product has excellent antibacterial, antivirus action, emphasis is answered to consider the safety issue of product.
The content of the invention
The present invention proposes a kind of disposable antibacterial spraying of plant type, and raw material selects pure natural plant extract, effectively reduction
Chemical composition is added, while improving Product Safety, effectively antibacterial, antiviral.The present invention, which is proposed, also proposed this plantation
The preparation method of the disposable antibacterial spraying of thing type, it is specific as follows：
A kind of disposable antibacterial spraying of plant type, is to include the aqueous solution of following raw material：10-20 parts of compound Chinese medicinal materials
Extract, 0.05-0.2 part benzalkonium chloride；The compound Chinese medicinal material extract is made up of the raw material of following parts by weight：Chrysanthemum indicum is carried
Take 2-4 parts of thing, 2-4 parts of Honegsukle flower P.E, 1-2 parts of dandelion extract, 0.09-0.2 parts of Baical Skullcap root P.E, licorice
0.06-0.2 parts.
It is preferred that, the Flos Chrysanthemi Indici extract, Honegsukle flower P.E, dandelion extract, Baical Skullcap root P.E, Radix Glycyrrhizae are extracted
The preparation method of thing is as follows：Each medicinal material is taken, with 70% alcohol steep 4h of 10 times of volumes, filtering is extracted 3 times, merging filtrate subtracts
Press dry dry, obtain each extract.
It is preferred that, it is to include the aqueous solution of following raw material：15 parts of compound Chinese medicinal material extracts, 0.1 part of benzene prick chlorine
Ammonium.
It is preferred that, the compound Chinese medicinal material extract is made up of the raw material of following parts by weight：3 parts of Flos Chrysanthemi Indici extract, gold
3 parts of honeysuckle flower extract, 2 parts of dandelion extract, 0.1 part of Baical Skullcap root P.E, 0.1 part of licorice.
It is preferred that, the auxiliary material of following parts by weight is also included in the aqueous solution：0.5-5 parts of glycerine, appropriate pH adjusting agent；Institute
PH adjusting agent is stated for hydrochloric acid, NaOH or sodium acid carbonate；Described is that target solution is adjusted into pH4.5-6.5's in preparing in right amount
Amount.
It is preferred that, the auxiliary agent of following parts by weight is also included in the aqueous solution：0.1-2 parts of NMF, Tween-80
0.2-2 parts, 0.2-1 parts of bleeding agent；The NMF is one kind in pyrrolidone sodium carboxylate and sodium lactate or it is mixed
Compound；The bleeding agent is water-solubleazone.
The invention also discloses a kind of preparation method of the disposable antibacterial spraying of plant type, comprise the following steps：
Taking compound Chinese medicine extract, plus 2 times of weight waters makes to be uniformly dispersed；
95% ethanol slowly is uniformly added into, side edged is stirred, it is 70% to make alcohol content, stands 24 hours, filtration, filtrate decompression
Ethanol is reclaimed, no alcohol taste is concentrated into, obtains concentrate；
Concentrate adds distilled water and dilutes concentrate to close to full dose, adds benzalkonium chloride, stirs evenly, adjusted with pH adjusting agent
PH to 4.5-6.5, plus distilled water are settled to full dose, cross 0.22 μm of miillpore filter, and filtration, packing is produced.
The invention also discloses the preparation method of the disposable antibacterial spraying of another plant type, comprise the following steps：
Taking compound Chinese medicine extract, plus 2 times of amount water makes to be uniformly dispersed；
95% ethanol slowly is uniformly added into, side edged is stirred, it is 70% to make alcohol content, stands 24 hours, filtration, filtrate decompression
Ethanol is reclaimed, no alcohol taste is concentrated into, obtains concentrate；
Concentrate, adds distilled water and dilutes concentrate to close to full dose, heating makes to boil, and glycerine, benzene are sequentially added while hot
Oronain is pricked, stirs evenly, is allowed to whole dissolvings, full dose is settled to pH adjusting agent regulation pH to 4.5-6.5, plus distilled water, while hot mistake
0.22 μm of miillpore filter, filtration, packing is produced.
The invention also discloses the preparation method of the disposable antibacterial spraying of another plant type, comprise the following steps：
Taking compound Chinese medicine extract, plus 2 times of amount water makes to be uniformly dispersed；
95% ethanol slowly is uniformly added into, side edged is stirred, it is 70% to make alcohol content, stands 24 hours, filtration, filtrate decompression
Ethanol is reclaimed, no alcohol taste is concentrated into, obtains concentrate；
After concentrate is sufficiently mixed with Tween-80, adds distilled water and dilute concentrate to close to full dose, heating makes to boil,
Glycerine, benzalkonium chloride, NMF, bleeding agent are sequentially added while hot, is stirred evenly, and are allowed to whole dissolvings, are adjusted with pH adjusting agent
PH to 4.5-6.5 is saved, plus distilled water is settled to full dose, and 0.22 μm of miillpore filter is crossed while hot, filtration, packing is produced.
The beneficial effects of the invention are as follows the disposable antibacterial spraying of plant type of some embodiments can be effectively antibacterial, separately
The disposable antibacterial Spray stability of plant type of some embodiments is good, and bacteriostasis can at least keep 1 year at room temperature, simultaneously
The preparation method of some embodiments is simple, quick.The disposable antibacterial spraying of the plant type of the present invention in addition also has feature：
1st, compound prescription, attenuation synergistic, not spirituosity.Formula is neutral, gentle, meets the requirement of child skin comfort level,
With rear skin is moist, use in winter is not chapped.Skin care composition is added, depth skin care effect, comfortable feel, profit is further functioned as
Sliding, suitable child on long-term is used.
2nd, Non-water washing, rapid-curing cutback, nontoxic, non-stimulated, efficient sterilizing.
3rd, it is adapted to infant (neonate) skin degerming, neonatal umbilical cord sterilization；It is also applied for making alcohol intolerance person
With, operation and injection site is sterilized, handwashing disinfection, surgical incision are sterilized, traumatic surface is sterilized, perineum mucous membrane disappears before surgery
Poison etc..
4th, the Ministry of Public Health is met《Disinfection technology standard》Requirement, broad-spectrum sterilization, Continuous sterilization.Kill pathogenic entero becteria, change
Purulence coccus, saccharomytes, common bacteria in nosocomial infection, mycobacteria, custom composition virus etc..
Embodiment
To describe technology contents, construction feature, institute's reached purpose and effect of the present invention in detail, embodiment is hereby enumerated below
It is explained in detail.
Embodiment 1
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 10 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Extracted in every 5.15 grams of compound Chinese medicinal material extracts containing 2 grams of Flos Chrysanthemi Indici extract, 2 grams of Honegsukle flower P.E, dandelion
1 gram of thing, 0.09 gram of Baical Skullcap root P.E, 0.06 gram of licorice.
Embodiment 2
The Flos Chrysanthemi Indici extract of embodiment 1, Honegsukle flower P.E, dandelion extract, Baical Skullcap root P.E, licorice
Preparation method it is as follows：
Each medicinal material is taken, with 70% alcohol steep 4h of 10 times of volumes, filtering is extracted 3 times, merging filtrate is dried under reduced pressure, and is obtained
To each extract.
Embodiment 3
The preparation method of the disposable antibacterial spraying of the plant type of embodiment 1, comprises the following steps：
Take 4 grams of Flos Chrysanthemi Indici extract, it is 4 grams of Honegsukle flower P.E, 2 grams of dandelion extract, 0.18 gram of Baical Skullcap root P.E, sweet
Careless 0.12 gram of extract, is well mixed, obtains 10.3 grams of compound Chinese medicinal material extract,.
10 grams of above-mentioned compound Chinese medicinal material extracts are taken, adding 20mL water makes to be uniformly dispersed；
95% ethanol slowly is uniformly added into, side edged is stirred, it is 70% to make alcohol content, stands 24 hours, filtration, filtrate decompression
Ethanol is reclaimed, no alcohol taste is concentrated into, obtains concentrate；
Concentrate adds distilled water to 990mL, adds 0.1 gram of benzalkonium chloride, stirs evenly, and pH to 4.5- is adjusted with pH adjusting agent
6.5, plus distilled water is settled to 1000mL, crosses 0.22 μm of miillpore filter, filtration, packing is produced.
Embodiment 4
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 10 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Extracted in every 10.4 grams of compound Chinese medicinal material extracts containing 4 grams of Flos Chrysanthemi Indici extract, 4 grams of Honegsukle flower P.E, dandelion
2 grams of thing, 0.2 gram of Baical Skullcap root P.E, 0.2 gram of licorice.
Embodiment 5
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 10 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Extracted in every 8.2 grams of compound Chinese medicinal material extracts containing 3 grams of Flos Chrysanthemi Indici extract, 3 grams of Honegsukle flower P.E, dandelion
2 grams of thing, 0.1 gram of Baical Skullcap root P.E, 0.1 gram of licorice.
Embodiment 6
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 10 grams of compound Chinese medicinal material extracts, 0.2 gram of benzene
Ammonium；Extracted in every 10.4 grams of compound Chinese medicinal material extracts containing 4 grams of Flos Chrysanthemi Indici extract, 4 grams of Honegsukle flower P.E, dandelion
2 grams of thing, 0.2 gram of Baical Skullcap root P.E, 0.2 gram of licorice.
Embodiment 7
Pricked in a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution containing 20 grams of compound Chinese medicinal material extracts, 0.05 gram of benzene
Oronain；Carried in every 10.4 grams of compound Chinese medicinal material extracts containing 4 grams of Flos Chrysanthemi Indici extract, 4 grams of Honegsukle flower P.E, dandelion
Take 2 grams of thing, 0.2 gram of Baical Skullcap root P.E, 0.2 gram of licorice.
Embodiment 8
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 15 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Extracted in every 10.4 grams of compound Chinese medicinal material extracts containing 4 grams of Flos Chrysanthemi Indici extract, 4 grams of Honegsukle flower P.E, dandelion
2 grams of thing, 0.2 gram of Baical Skullcap root P.E, 0.2 gram of licorice.
Embodiment 9
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 15 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Extracted in every 10.4 grams of compound Chinese medicinal material extracts containing 4 grams of Flos Chrysanthemi Indici extract, 4 grams of Honegsukle flower P.E, dandelion
2 grams of thing, 0.2 gram of Baical Skullcap root P.E, 0.2 gram of licorice, also contain 0.5 gram of glycerine in the aqueous solution.
Embodiment 10
The preparation method of the disposable antibacterial spraying of the plant type of embodiment 9, comprises the following steps：
Take 8 grams of Flos Chrysanthemi Indici extract, it is 8 grams of Honegsukle flower P.E, 4 grams of dandelion extract, 0.4 gram of Baical Skullcap root P.E, sweet
Careless 0.4 gram of extract, is well mixed, obtains 20.8 grams of compound Chinese medicinal material extract,.
15 grams of above-mentioned compound Chinese medicinal material extracts are taken, adding 30mL water makes to be uniformly dispersed；
95% ethanol slowly is uniformly added into, side edged is stirred, it is 70% to make alcohol content, stands 24 hours, filtration, filtrate decompression
Ethanol is reclaimed, no alcohol taste is concentrated into, obtains concentrate；
Concentrate adds distilled water to 990mL, and 0.5 gram of glycerine is sequentially added while hot, 0.1 gram of benzalkonium chloride is added, stirred evenly,
PH to 4.5-6.5 is adjusted with pH adjusting agent, plus distilled water is settled to 1000mL, crosses 0.22 μm of miillpore filter, filtration, packing is
.
Embodiment 11
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 15 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Extracted in every 10.4 grams of compound Chinese medicinal material extracts containing 4 grams of Flos Chrysanthemi Indici extract, 4 grams of Honegsukle flower P.E, dandelion
2 grams of thing, 0.2 gram of Baical Skullcap root P.E, 0.2 gram of licorice, also contain 5 grams of glycerine in the aqueous solution.
Embodiment 12
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 15 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Extracted in every 10.4 grams of compound Chinese medicinal material extracts containing 4 grams of Flos Chrysanthemi Indici extract, 4 grams of Honegsukle flower P.E, dandelion
2 grams of thing, 0.2 gram of Baical Skullcap root P.E, 0.2 gram of licorice, also contain 1 gram of glycerine in the aqueous solution.Also contain pyrrole in the aqueous solution
0.1 gram of pyrrolidone carboxylic acid's sodium, 0.2 gram of Tween-80,0.2 gram of water-solubleazone.
Embodiment 13
The preparation method of the disposable antibacterial spraying of the plant type of embodiment 12, comprises the following steps：
Take 8 grams of Flos Chrysanthemi Indici extract, it is 8 grams of Honegsukle flower P.E, 4 grams of dandelion extract, 0.4 gram of Baical Skullcap root P.E, sweet
Careless 0.4 gram of extract, is well mixed, obtains 20.8 grams of compound Chinese medicinal material extract.
15 grams of above-mentioned compound Chinese medicinal material extracts are taken, adding 30mL water makes to be uniformly dispersed；
95% ethanol slowly is uniformly added into, side edged is stirred, it is 70% to make alcohol content, stands 24 hours, filtration, filtrate decompression
Ethanol is reclaimed, no alcohol taste is concentrated into, obtains concentrate；
After concentrate and 0.2 gram of Tween-80 are sufficiently mixed, distilled water is added to 990mL, heating makes to boil, while hot successively
1 gram of glycerine, 0.1 gram of benzalkonium chloride, 0.1 gram of pyrrolidone sodium carboxylate, 0.2 gram of water-solubleazone are added, is stirred evenly, is allowed to all molten
Solution, pH to 4.5-6.5 is adjusted with pH adjusting agent, plus distilled water is settled to 1000mL, and 0.22 μm of miillpore filter is crossed while hot, is filtered,
Packing is produced.
Embodiment 14
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 15 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Extracted in every 10.4 grams of compound Chinese medicinal material extracts containing 4 grams of Flos Chrysanthemi Indici extract, 4 grams of Honegsukle flower P.E, dandelion
2 grams of thing, 0.2 gram of Baical Skullcap root P.E, 0.2 gram of licorice, also contain 1 gram of glycerine in the aqueous solution.Also contain pyrrole in the aqueous solution
1 gram of pyrrolidone carboxylic acid's sodium, 1 gram of sodium lactate, 2 grams of Tween-80,1 gram of water-solubleazone.
Reference examples 1
Containing 10 grams of Flos Chrysanthemi Indici extracts, 0.1 gram of benzalkonium chloride in a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution.
Reference examples 2
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution containing 5 grams of Flos Chrysanthemi Indici extracts, 5 grams of Honegsukle flower P.Es,
0.1 gram of benzalkonium chloride.
Reference examples 3
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 10 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Contain 3 grams of Flos Chrysanthemi Indici extract, 3 grams of Honegsukle flower P.E, dandelion extract 2 in every 8 grams of compound Chinese medicinal material extracts
Gram.
Reference examples 4
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 10 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Extracted in every 8.1 grams of compound Chinese medicinal material extracts containing 3 grams of Flos Chrysanthemi Indici extract, 3 grams of Honegsukle flower P.E, dandelion
2 grams of thing, 0.1 gram of Baical Skullcap root P.E.
Reference examples 5
In a kind of disposable antibacterial spraying of plant type, its 1L aqueous solution chlorine is pricked containing 10 grams of compound Chinese medicinal material extracts, 0.1 gram of benzene
Ammonium；Extracted in every 8.1 grams of compound Chinese medicinal material extracts containing 3 grams of Flos Chrysanthemi Indici extract, 3 grams of Honegsukle flower P.E, dandelion
2 grams of thing, 0.1 gram of licorice.
Reference examples 6
Containing 10 grams of compound Chinese medicinal material extracts in a kind of antibacterial spraying, its 1L aqueous solution；Every 10.4 grams of compound Chinese medicines
In material extract containing 4 grams of Flos Chrysanthemi Indici extract, 4 grams of Honegsukle flower P.E, 2 grams of dandelion extract, 0.2 gram of Baical Skullcap root P.E,
0.2 gram of licorice.
Reference examples 7
Containing 0.2 gram of benzalkonium chloride in a kind of antibacterial spraying, its 1L aqueous solution.
The product bacteriostasis property of experimental example 1 is tested：
Test sample is the antibacterial spraying of embodiment 1,4-8 and reference examples 1-7.
Test organisms：
Bacterium：Staphylococcus aureus (ATCC 6538), Escherichia coli (8099 or ATCC 25922)
Saccharomycete：Candida albicans (ATCC 10231)
It is prepared by bacterium solution：
The nutrient agar inclined-plane fresh cultured thing (18-24h) in bacterial strain 3-14 generations is taken, 5mL0.03mol/L phosphorus is used
Phthalate buffer (hereinafter referred to as PBS) washes lower lawn, bacterium is diluted to required concentration with above-mentioned PBS after suspending uniformly.
Operating procedure：
Test organisms 24h slant cultures are washed down with PBS, be made bacteria suspension (it is required that concentration be：With 100 μ L drops in 5m1
In sample liquid, bacterial count recovered is 1 × 104-9×104cfu/mL)。
It is 5mL test samples by test liquid, control sample liquid is 5mL sterilized waters, each 4 pipe.
Above-mentioned bacteria suspension is taken, 100 μ L are added dropwise in test liquid and control sample liquid each respectively, uniform mixing.Start meter
When, effect 2,5,10,20min, difference sample liquid (0.5mL) are thrown in people PBS containing 5mL test tube, are fully mixed, and make suitably dilution,
Then wherein 2-3 dilution factor is taken, 0.5mL is drawn respectively, two plates are placed in, with cool to 40-45 DEG C of nutrient agar culture
Base (bacterium) or sabouraud's agar (saccharomycete) 15mL are poured into, and are rotated plate, are made its full and uniform, turned over after agar solidification
Turn flat board, 35 DEG C of scholars, 2 DEG C of culture 48h (bacterium) or 72h (saccharomycete), make viable bacteria colony counting.
Experiment is repeated 3 times, and bacteriostasis rate is calculated as follows：
X=(A-B)/A × 100%
In formula：X --- bacteriostasis rate, %；
A --- check sample average colony number；
B --- subject sample mean clump count.
Evaluation criterion：
Bacteriostasis rate >=50-90%, product has bacteriostasis, bacteriostasis rate >=90%, and product has stronger bacteriostasis.
The product bacteriostasis property of table 1 is tested
* number of symbols is identical represents no significant difference, and number difference indicates significant difference (P=0.05)
As it can be seen from table 1 reference examples 1-5 bacteriostasis rate is between 30-40%, and embodiment 1,4,5 reaches
More than 90%, illustrate Flos Chrysanthemi Indici extract, Honegsukle flower P.E, dandelion extract, Baical Skullcap root P.E, licorice this
The compound Chinese medicinal material extract of five kinds of mixtures has synergy with benzalkonium chloride, indispensable.The bacteriostasis rate of reference examples 6 exists
20% or so, less than 45% effect of reference examples 7, illustrate that 4 grams of Flos Chrysanthemi Indici extract, 4 grams of Honegsukle flower P.E, dandelion are extracted
2 grams of thing, 0.2 gram of Baical Skullcap root P.E, the compound Chinese medicinal material extract of 0.2 gram of licorice have fungistatic effect, 0.1% benzene
Prick the compound Chinese medicinal material extract that oronain fungistatic effect is better than 1%.And the reality of benzalkonium chloride and compound Chinese medicinal material extract combination
Example 1,4,5,6-8 bacteriostasis rates are applied more than 90%, far beyond both simple superposition, illustrates that both have synergy.
It is optimal wherein with embodiment 8, effect has reached 99.99%, with remaining benzalkonium chloride and compound Chinese medicinal material extract combination
Also there were significant differences for embodiment.
The product antimicrobial stability of experimental example 2 is tested
Accelerated test：Test sample is the antibacterial spraying of embodiment 9,11,12,14.
Accelerated test test condition：Test sample is put in 54-57 DEG C of insulating box 14 days, relative humidity is kept>75%, enter
Row bacteriostasis property is tested.
Evaluation criterion：Product is through 54 DEG C of accelerated tests, and its bacteriostasis rate reaches standard value specified in bacteriostasis property test, production
The bacteriostasis of product is at least kept for 1 year at room temperature.
The product antimicrobial stability of table 2 is tested
From table 2 it can be seen that result of the test shows, the character of product is stablized under acceleration conditions, and bacteriostasis is in room temperature
Under can at least keep 1 year.
In summary, only the preferred embodiments of the invention, does not limit protection scope of the present invention with this, all according to the present invention
Equivalence changes and modification that the scope of the claims and description are made, are all within the scope of patent of the present invention covers.
Claims (9)
1. the disposable antibacterial spraying of a kind of plant type, it is characterised in that be to include the aqueous solution of following raw material：10-20 parts
Compound Chinese medicinal material extract, 0.05-0.2 part benzalkonium chloride；The compound Chinese medicinal material extract by following parts by weight raw material group
Into：2-4 parts of Flos Chrysanthemi Indici extract, 2-4 parts of Honegsukle flower P.E, 1-2 parts of dandelion extract, Baical Skullcap root P.E 0.09-0.2
Part, 0.06-0.2 parts of licorice.
2. the disposable antibacterial spraying of plant type as claimed in claim 1, it is characterised in that the Flos Chrysanthemi Indici extract, honeysuckle
Extract, dandelion extract, Baical Skullcap root P.E, licorice preparation method it is as follows：Each medicinal material is taken, with 10 times of volumes
70% alcohol steep 4h, filtering is extracted 3 times, merging filtrate is dried under reduced pressure, and obtains each extract.
3. the disposable antibacterial spraying of plant type as claimed in claim 1, it is characterised in that be to include the water of following raw material
Solution：15 parts of compound Chinese medicinal material extracts, 0.1 part of benzalkonium chloride.
4. the disposable antibacterial spraying of plant type as claimed in claim 1, it is characterised in that the compound Chinese medicinal material extract is under
The raw material composition of row parts by weight：3 parts of Flos Chrysanthemi Indici extract, 3 parts of Honegsukle flower P.E, 2 parts of dandelion extract, Baical Skullcap root P.E
0.1 part, 0.1 part of licorice.
5. the disposable antibacterial spraying of plant type as claimed in claim 1, it is characterised in that also include in the aqueous solution following heavy
Measure the auxiliary material of part：0.5-5 parts of glycerine, appropriate pH adjusting agent；The pH adjusting agent is hydrochloric acid, NaOH or sodium acid carbonate；Institute
State the appropriate amount for target solution to be adjusted to pH4.5-6.5 in preparing.
6. the disposable antibacterial spraying of plant type as claimed in claim 3, it is characterised in that also include in the aqueous solution following heavy
Measure the auxiliary agent of part：0.1-2 parts of NMF, 0.2-2 parts of Tween-80,0.2-1 parts of bleeding agent；The NMF
For one kind in pyrrolidone sodium carboxylate and sodium lactate or its mixture；The bleeding agent is water-solubleazone.
7. the preparation method of the disposable antibacterial spraying of plant type as claimed in claim 1, it is characterised in that comprise the following steps：
Taking compound Chinese medicine extract, plus 2 times of weight waters makes to be uniformly dispersed；
95% ethanol slowly is uniformly added into, side edged is stirred, it is 70% to make alcohol content, stands 24 hours, and filtration, filtrate decompression is reclaimed
Ethanol, is concentrated into no alcohol taste, obtains concentrate；
Concentrate add distilled water to close to full dose dilute concentrate, add benzalkonium chloride, stir evenly, with pH adjusting agent adjust pH to
4.5-6.5, plus distilled water are settled to full dose, cross 0.22 μm of miillpore filter, and filtration, packing is produced.
8. the preparation method of the disposable antibacterial spraying of plant type as claimed in claim 5, it is characterised in that comprise the following steps：
Taking compound Chinese medicine extract, plus 2 times of amount water makes to be uniformly dispersed；
95% ethanol slowly is uniformly added into, side edged is stirred, it is 70% to make alcohol content, stands 24 hours, and filtration, filtrate decompression is reclaimed
Ethanol, is concentrated into no alcohol taste, obtains concentrate；
Concentrate, adds distilled water and dilutes concentrate to close to full dose, heating makes to boil, glycerine, benzene are sequentially added while hot and pricks chlorine
Ammonium, is stirred evenly, and is allowed to whole dissolvings, and pH to 4.5-6.5 is adjusted with pH adjusting agent, plus distilled water is settled to full dose, and 0.22 μ is crossed while hot
M miillpore filters, filtration, packing is produced.
9. the preparation method of the disposable antibacterial spraying of plant type as claimed in claim 6, it is characterised in that comprise the following steps：
Taking compound Chinese medicine extract, plus 2 times of amount water makes to be uniformly dispersed；
95% ethanol slowly is uniformly added into, side edged is stirred, it is 70% to make alcohol content, stands 24 hours, and filtration, filtrate decompression is reclaimed
Ethanol, is concentrated into no alcohol taste, obtains concentrate；
After concentrate is sufficiently mixed with Tween-80, adds distilled water and dilute concentrate to close to full dose, heating makes to boil, while hot
Glycerine, benzalkonium chloride, NMF, bleeding agent are sequentially added, is stirred evenly, whole dissolvings are allowed to, pH is adjusted with pH adjusting agent
Full dose is settled to 4.5-6.5, plus distilled water, 0.22 μm of miillpore filter is crossed while hot, filtration, packing is produced.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710203236.9A CN106943454A (en) | 2017-03-30 | 2017-03-30 | A kind of disposable antibacterial spraying of plant type and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710203236.9A CN106943454A (en) | 2017-03-30 | 2017-03-30 | A kind of disposable antibacterial spraying of plant type and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106943454A true CN106943454A (en) | 2017-07-14 |
Family
ID=59474991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710203236.9A Pending CN106943454A (en) | 2017-03-30 | 2017-03-30 | A kind of disposable antibacterial spraying of plant type and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106943454A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107310837A (en) * | 2017-07-24 | 2017-11-03 | 苏州康利捷消毒科技有限公司 | A kind of skin of face thimerosal and its preparation spray bottle |
| CN108653407A (en) * | 2018-06-12 | 2018-10-16 | 蒙城县众扶医联医疗器械有限公司 | A kind of thimerosal and preparation method thereof for medical test |
| CN112107499A (en) * | 2020-09-22 | 2020-12-22 | 安徽三点清药业有限公司 | Method for preparing hand-washing-free disinfectant |
| CN112516237A (en) * | 2020-12-15 | 2021-03-19 | 郑州百瑞动物药业有限公司 | Sterilization and deodorization spray for pets and preparation method thereof |
| CN113041195A (en) * | 2021-03-31 | 2021-06-29 | 康柏利科技（苏州）有限公司 | Washing-free foam antibacterial hand disinfectant |
| CN115400158A (en) * | 2022-01-20 | 2022-11-29 | 上海迈之悦生物科技有限公司 | Safe and stable novel medical disinfectant and preparation method thereof |
| CN116437810A (en) * | 2020-10-20 | 2023-07-14 | 联合利华知识产权控股有限公司 | Method for microbiome equilibration |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1397168A (en) * | 2001-07-13 | 2003-02-19 | 周茜 | Composite disinfectant |
| CN1548035A (en) * | 2003-05-21 | 2004-11-24 | 哈药集团三精制药有限公司 | Washing skin care article of honeysuckle and skullcap root |
| CN101293012A (en) * | 2008-06-20 | 2008-10-29 | 吉林省通化振国药业有限公司 | Antiviral honeysuckle flower Chinese medicine compound preparation and preparation technique |
| CN101564421A (en) * | 2009-05-25 | 2009-10-28 | 杭州天诚药业有限公司 | Chinese medicine externally used washing lotion for gynaecologic inflammation and preparing technique |
| CN101780172A (en) * | 2010-03-29 | 2010-07-21 | 贵阳德昌祥药业有限公司 | Bacteriostatic washing liquor with high bacteriostatic action and method for preparing same |
| CN102908306A (en) * | 2012-11-13 | 2013-02-06 | 河南亚卫动物药业有限公司 | Fibrauretine external preparation for beasts and birds and preparation method thereof |
| CN103409990A (en) * | 2013-08-02 | 2013-11-27 | 东华大学 | Finishing agent used for infant red butt hygiene care as well as preparation method and application thereof |
| CN103461607A (en) * | 2013-09-26 | 2013-12-25 | 王文泉 | Honeysuckle compound tea |
| CN103599032A (en) * | 2013-12-04 | 2014-02-26 | 苏州市洋海电子有限公司 | Compound dandelion wet wipe |
| CN103622876A (en) * | 2013-12-09 | 2014-03-12 | 苏州市洋海电子有限公司 | Hygienic disinfectant moist towelette |
| CN103637948A (en) * | 2013-12-04 | 2014-03-19 | 苏州市洋海电子有限公司 | Compound honeysuckle flower wet tissue |
| CN104107216A (en) * | 2014-05-16 | 2014-10-22 | 清远容大生物工程有限公司 | Traditional Chinese medicine compound preparation and its preparation method and use |
| CN104523545A (en) * | 2014-12-22 | 2015-04-22 | 合肥天一生物技术研究所 | Antibacterial skincare hand disinfectant and preparation method thereof |
| CN105194005A (en) * | 2014-08-20 | 2015-12-30 | 张光荣 | Disinfectant for cleaning up wounds |
| CN105250212A (en) * | 2015-10-27 | 2016-01-20 | 合肥天一生物技术研究所 | No-washing type hand disinfectant with moisturizing and bacterium preventing effects and preparation method thereof |
| CN105770208A (en) * | 2016-03-14 | 2016-07-20 | 贵州省中国科学院天然产物化学重点实验室 | Herbal medicine compounded extract as well as preparation method and application thereof |
-
2017
- 2017-03-30 CN CN201710203236.9A patent/CN106943454A/en active Pending
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1397168A (en) * | 2001-07-13 | 2003-02-19 | 周茜 | Composite disinfectant |
| CN1548035A (en) * | 2003-05-21 | 2004-11-24 | 哈药集团三精制药有限公司 | Washing skin care article of honeysuckle and skullcap root |
| CN101293012A (en) * | 2008-06-20 | 2008-10-29 | 吉林省通化振国药业有限公司 | Antiviral honeysuckle flower Chinese medicine compound preparation and preparation technique |
| CN101564421A (en) * | 2009-05-25 | 2009-10-28 | 杭州天诚药业有限公司 | Chinese medicine externally used washing lotion for gynaecologic inflammation and preparing technique |
| CN101780172A (en) * | 2010-03-29 | 2010-07-21 | 贵阳德昌祥药业有限公司 | Bacteriostatic washing liquor with high bacteriostatic action and method for preparing same |
| CN102908306A (en) * | 2012-11-13 | 2013-02-06 | 河南亚卫动物药业有限公司 | Fibrauretine external preparation for beasts and birds and preparation method thereof |
| CN103409990A (en) * | 2013-08-02 | 2013-11-27 | 东华大学 | Finishing agent used for infant red butt hygiene care as well as preparation method and application thereof |
| CN103461607A (en) * | 2013-09-26 | 2013-12-25 | 王文泉 | Honeysuckle compound tea |
| CN103599032A (en) * | 2013-12-04 | 2014-02-26 | 苏州市洋海电子有限公司 | Compound dandelion wet wipe |
| CN103637948A (en) * | 2013-12-04 | 2014-03-19 | 苏州市洋海电子有限公司 | Compound honeysuckle flower wet tissue |
| CN103622876A (en) * | 2013-12-09 | 2014-03-12 | 苏州市洋海电子有限公司 | Hygienic disinfectant moist towelette |
| CN104107216A (en) * | 2014-05-16 | 2014-10-22 | 清远容大生物工程有限公司 | Traditional Chinese medicine compound preparation and its preparation method and use |
| CN105194005A (en) * | 2014-08-20 | 2015-12-30 | 张光荣 | Disinfectant for cleaning up wounds |
| CN104523545A (en) * | 2014-12-22 | 2015-04-22 | 合肥天一生物技术研究所 | Antibacterial skincare hand disinfectant and preparation method thereof |
| CN105250212A (en) * | 2015-10-27 | 2016-01-20 | 合肥天一生物技术研究所 | No-washing type hand disinfectant with moisturizing and bacterium preventing effects and preparation method thereof |
| CN105770208A (en) * | 2016-03-14 | 2016-07-20 | 贵州省中国科学院天然产物化学重点实验室 | Herbal medicine compounded extract as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王慧琴: "《实用消毒剂生产技术与使用方法》", 31 October 2006, 江西科学技术出版社 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107310837A (en) * | 2017-07-24 | 2017-11-03 | 苏州康利捷消毒科技有限公司 | A kind of skin of face thimerosal and its preparation spray bottle |
| CN108653407A (en) * | 2018-06-12 | 2018-10-16 | 蒙城县众扶医联医疗器械有限公司 | A kind of thimerosal and preparation method thereof for medical test |
| CN112107499A (en) * | 2020-09-22 | 2020-12-22 | 安徽三点清药业有限公司 | Method for preparing hand-washing-free disinfectant |
| CN112107499B (en) * | 2020-09-22 | 2023-08-25 | 安徽三点清药业有限公司 | Preparation method of hand-washing-free disinfection preparation |
| CN116437810A (en) * | 2020-10-20 | 2023-07-14 | 联合利华知识产权控股有限公司 | Method for microbiome equilibration |
| CN112516237A (en) * | 2020-12-15 | 2021-03-19 | 郑州百瑞动物药业有限公司 | Sterilization and deodorization spray for pets and preparation method thereof |
| CN113041195A (en) * | 2021-03-31 | 2021-06-29 | 康柏利科技（苏州）有限公司 | Washing-free foam antibacterial hand disinfectant |
| CN115400158A (en) * | 2022-01-20 | 2022-11-29 | 上海迈之悦生物科技有限公司 | Safe and stable novel medical disinfectant and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106943454A (en) | A kind of disposable antibacterial spraying of plant type and preparation method thereof | |
| CN101048064B (en) | Antiseptic compositions and methods of use | |
| CN106342946B (en) | A kind of air purifying and sterilizing agent and preparation method | |
| CN104082353A (en) | Pure traditional Chinese medicine disinfectant and preparation method thereof | |
| CN101810541B (en) | Disinfecting body wash | |
| CN103356999B (en) | Novel marine organism washing-free disinfection solution and its application | |
| CN103356738A (en) | Skin disinfection gel and its application | |
| CN101642449A (en) | Skin mucous membrane disinfectants and preparation method thereof | |
| KR20150141938A (en) | Process for producing silver-ion antibacterial liquid, silver-ion antibacterial liquid produced by said process, and silver-ion-containing product containing said antibacterial liquid | |
| CN102755640A (en) | Plant chinese herbal medicine essence complex disinfectant | |
| CN106619309A (en) | Pet nursing agent and preparation method thereof | |
| CN108371191A (en) | A kind of air antiseptic and its preparation method and application | |
| KR101500514B1 (en) | Wet Tissue Containing Antiseptic Composition without Skin Irritation | |
| CN104547275A (en) | Hand essential oil skin-care disinfection gel and preparation method thereof | |
| CN104666285B (en) | The disposable quick-drying detergent for cleaning hand of sodium azulenesulfonate antiallergy | |
| CN104523466A (en) | Chinese herbal medicinal skin mucosa disinfection wet wipe | |
| CN104798823A (en) | Bactericide for clinical laboratory | |
| CN104435607A (en) | Chinese herbal medicine skin mucosa disinfectant | |
| CN104666317B (en) | A kind of neonatal umbilical cord antibacterial anti-inflammatory liquid and its preparation method and application | |
| CN108904329A (en) | A kind of environment friendly bacteriostatic polyacid hand cleanser and preparation method thereof | |
| CN104094979A (en) | Willow leaf for preparing sanitizer | |
| CN107714501A (en) | One kind is without alcohol foam hand sanitizing fluid | |
| CN102754666A (en) | Medical institution object surface herbal disinfectant | |
| CN104784164A (en) | Protein-based skin cleaning disinfectant and preparation method thereof | |
| CN111481567A (en) | Compound ozone oil and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170714 |