CN108721449A - One kind effectively enhancing the gel of anti-HPV infection for inhibiting HPV infection - Google Patents

One kind effectively enhancing the gel of anti-HPV infection for inhibiting HPV infection Download PDF

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Publication number
CN108721449A
CN108721449A CN201810854717.0A CN201810854717A CN108721449A CN 108721449 A CN108721449 A CN 108721449A CN 201810854717 A CN201810854717 A CN 201810854717A CN 108721449 A CN108721449 A CN 108721449A
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hpv infection
gel
extract
bioprotein
chitosan
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杜阳
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XI'AN WANHE PHARMACEUTICAL CO Ltd
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XI'AN WANHE PHARMACEUTICAL CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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Abstract

The present invention provides one kind for inhibiting HPV infection, effectively enhances the gel of anti-HPV infection, is made of the raw material of following weight ratio：Propolis, frutus cnidii, kuh-seng, frankincense, safflower, Radix Angelicae Sinensis, chitosan, sodium hyaluronate, biological peptide, bioprotein；Promote cell metabolism by the drug effect that pharmaceutical composition plays, to enhance absorbability of the cell to drug, sodium hyaluronate and chitosan, biological peptide, the combination of bioprotein, it can effectively moisturize the skin, and thin film is formed in skin surface, effectively block the intrusion of alien bacteria, and quick repairing skin tissue, Wound healing power of regeneration is improved, the various plants extract in the gel can also improve immunity of organisms, can play good antiviral effect.

Description

One kind effectively enhancing the gel of anti-HPV infection for inhibiting HPV infection
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to one kind effectively enhancing anti-HPV infection for inhibiting HPV infection Gel and preparation method thereof.
Background technology
HPV is writing a Chinese character in simplified form for human papilloma virus, is a kind of DNA virus with high degree of specificity, the HPV being currently known Virus can cause mankind's benign tumour and wart, the periungual wart being such as happened at around finger and toe nail to be happened at face, metastomium Flat wart, clinically it, which is divided into much hypotypes, the virus main infection region, human epidermal and mucous membrane scaly epithelium, until It is modern it is separated go out more than 130 kinds, different types causes different clinical manifestations, can be divided into according to the tissue site difference of infringement：
(1) skin low risk：It is related to verruca vulgaris, flat wart, plantar wart etc. including HPV-1,2,3,4,7,10,12,15 etc.；
(2) skin high-risk-type：Related with epidermodysplasia verruciformis including HPV-5,8,14,17,20,36,38, other are also With may the related malignant tumour of HPV infection include：Carcinoma of vulva, carcinoma of penis, cancer of anus, prostate cancer, carcinoma of urinary bladder；
(3) mucous membrane low risk：Such as HPV-6,11,13,32,34,40,42,43,44,53,54 and infection genitals, anus Door, pars oralis pharyngis, esophageal mucosa；
(4) mucous membrane high-risk-type：HPV-16,18,30,31,33,35,39 and cervical carcinoma, the carcinoma of the rectum, carcinoma of mouth, carcinoma of tonsil Deng.
At present for the treatment of HPV mainly by operation, injection injection and oral drug therapy, these methods are due to being Western medicine, it is big for actual bodily harm side effect, also by external medication, such as by being administered at sufferer, common medicine Object has suppository, effervescent tablet etc., but the more or less existing defects of these drugs, effect more single.
Invention content
According to above-mentioned elaboration, the purpose of the present invention is to provide one kind for inhibiting HPV infection, effectively enhances anti-HPV senses Gel of dye and preparation method thereof, main thought are the compatibility principle using Chinese medicine monarch, realize to HPV viruse Good supression enhances human body anti-infection ability.
Technical solution provided by the invention：One kind effectively enhancing the gel of anti-HPV infection for inhibiting HPV infection, be by The raw material of following weight ratio is made：
Propolis 1%~3%, frutus cnidii 8%~15%, kuh-seng 1%~3%, frankincense 1%~3%, safflower 4%~ 6%, Radix Angelicae Sinensis 1%~6%, chitosan 1%~3%, sodium hyaluronate 2%~4%, biological peptide 1%~3%, bioprotein 1%~ 3%, remaining is purified water.
In above-mentioned technical proposal, propolis 1%, frutus cnidii 8%, kuh-seng 1%, frankincense 1%, safflower 4%, Radix Angelicae Sinensis 1%, shell Glycan 1%, sodium hyaluronate 2%, biological peptide 1%, bioprotein 1%, remaining be purified water.
Provided by the invention a kind of for inhibiting HPV infection, effectively enhancing the gel process for preparing of anti-HPV infection is：It will The raw material：Propolis extract, the frutus cnidii extraction of chitosan, sodium hyaluronate, biological peptide, bioprotein and parts by weight Object, shrubby sophora extract, Olibanum extract, safranine flower extract, angelica extract mixing, are added purified water and mix gel.
The extraction of Chinese medicine uses aqueous solvent extracting mode, the active ingredient of extraction.
The present invention based on to HPV pathogenesis and treatment principle, compatibility rationally, science, it is nontoxic through a large amount of clinical verifications Without side-effects, product of the invention is applied to after affected part, can be diffused to uncomfortable place rapidly, be goed deep into skin texture, sent out by pharmaceutical composition The drug effect waved promotes cell metabolism, to enhance absorbability of the cell to drug, sodium hyaluronate and chitosan, biological peptide, The combination of bioprotein can be moisturized the skin effectively, and form thin film in skin surface, effectively block invading for alien bacteria Enter, and quick repairing skin tissue, improve Wound healing power of regeneration, the various plants extract in the gel can also improve Immunity of organisms can play good antiviral effect.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below, it is clear that described embodiment is only this Invention a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art exist The every other embodiment obtained under the premise of creative work is not made, shall fall within the protection scope of the present invention.
The compatibility of drugs of the present invention is reasonable, and component effect is：
Propolis has the effect of moisturizing myogenic, anti-inflammatory analgetic.
Frutus cnidii, warm-natured, bitter return kidney channel, the present invention to utilize antibacterial, antimycotic, anti-inflammatory effect.
Kuh-seng, bitter is cold in nature, the thoughts of returning home, liver, stomach, large intestine, bladder warp, has heat-clearing, eliminating dampness, the effect of desinsection.
Frankincense, acrid flavour, hardship are warm-natured.The thoughts of returning home, liver, the spleen channel, the present invention utilize frankincense anti-inflammatory, promoting blood circulation analgesic therapy, detumescence and promoting granulation Function.
The effect of safflower, function of promoting blood circulation to disperse blood clots is strong, and the present invention utilizes safflower promoting blood circulation and removing blood stasis, swelling and pain relieving.
Radix Angelicae Sinensis, it is sweet in flavor warm-natured, it enriches blood；Promoting blood circulation；Menstruction regulating and pain relieving.
Sodium hyaluronate plays the benefits of lubrication moisturizing and nourishing isolation is viral
Biological peptide adjusts the physiological function of internal cell, activates related enzyme system in vivo, promotes the permeability of intermediate supersession film The effect of.
Bioprotein, enhancing is immune, hormone control, antibacterial, it is antiviral the effect of.
Chitosan is the effect of thickening.
According to above-mentioned component and compatibility principle analysis, the present invention, following embodiment is disclosed.
Embodiment：
It takes：One kind effectively enhances the gel of anti-HPV infection, is by the raw material system of following parts by weight for inhibiting HPV infection At：
Common cnidium fruit P.E 80g that propolis 10g that propolis effective content is 10%, frutus cnidii effective content are 10%, hardship Join the shrubby sophora extract 10g that alkali effective content is 98%, the frankincense seed extract 10g that frankincense effective content is 10%, safflower Angelica extract 10g that safranine flower extract 40g that effective content is 10%, Radix Angelicae Sinensis effective content are 10%, chitosan 10g, Sodium hyaluronate 20g, biological peptide 10g, bioprotein 10g plus purified water stir evenly gelled, mixture is most to 1000g Weight afterwards is 1000g.
In use, Chinese medicine composition gel is applied in affected part by patient.
To show that the antiviral effect of the present invention, the embodiment of the present invention do clinical test：
Clinical test
1, subjects：300 HPV viruse the infecteds, wherein 160 low dangerous type HPV infections, 140 high-risk types HPV infection.
2, the age：
In (1) 160 low dangerous type HPV infection patient：Minimal ages 18 years old, max age 50 years old；
In (2) 140 high-risk type HPV infection patients：Minimal ages 17 years old, max age 52 years old.
3, the course of disease is distributed：
In (1) 135 low dangerous type HPV infection patient：It is most 2 months short, longest 55 months；
In (2) 115 high-risk type HPV infection patients：It is most 1 month short, longest 24 months.
4, observation and therapy：Gel produced by the present invention smears affected part, and low danger type HPV infection patient uses 4 Further consultation after month；Further consultation after high-risk type HPV infection patient uses 6 months.
5, criterion：
(1) effective：HPV turns out cloudy.
(2) in vain, HPV does not turn out cloudy.
6, treatment results：It is shown in Table 1.
Table 1
Number It is effective In vain Total effective rate (%)
Low danger type 160 148 12 92.5
High-risk type 140 119 21 85
Show from table 1：Gynecological gel produced by the present invention is 92.5% for the effective percentage of low dangerous type HPV infection；Needle Effective percentage to high-risk type HPV infection is 85%.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain Lid is within protection scope of the present invention.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (2)

1. one kind effectively enhancing the gel of anti-HPV infection for inhibiting HPV infection, it is characterised in that：It is by following weight ratio Raw material is made：Propolis 1%~3%, frutus cnidii 8%~15%, kuh-seng 1%~3%, frankincense 1%~3%, safflower 4%~ 6%, Radix Angelicae Sinensis 1%~6%, chitosan 1%~3%, sodium hyaluronate 2%~4%, biological peptide 1%~3%, bioprotein 1%~ 3%, remaining is purified water.
By the raw material：Propolis extract, the frutus cnidii of chitosan, sodium hyaluronate, biological peptide, bioprotein and parts by weight Extract, shrubby sophora extract, Olibanum extract, safranine flower extract, angelica extract mixing, addition purified water mix solidifying Glue.
2. it is according to claim 1 a kind of for inhibiting HPV infection, effectively enhance the gel of anti-HPV infection, feature exists In：It is made of the raw material of following weight ratio：Propolis 1%, frutus cnidii 8%, kuh-seng 1%, frankincense 1%, safflower 4%, Radix Angelicae Sinensis 1%, chitosan 1%, sodium hyaluronate 2%, biological peptide 1%, bioprotein 1%, remaining be purified water.
CN201810854717.0A 2018-07-30 2018-07-30 One kind effectively enhancing the gel of anti-HPV infection for inhibiting HPV infection Pending CN108721449A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109529015A (en) * 2018-12-12 2019-03-29 上海美哈医药科技有限公司 A kind of women HPV antibacterial agent and preparation method thereof
CN110151899A (en) * 2019-06-28 2019-08-23 吴江平 A kind of Chinese medicine draft formula and its fermentation preparation fighting HPV viruse
CN110227060A (en) * 2019-04-29 2019-09-13 广东旭睿美医疗科技有限公司 Containing the anti-HPV gel of giant salamander oligosaccharide peptide
CN110507816A (en) * 2019-09-20 2019-11-29 江西善行生物科技有限公司 It is a kind of for removing the compound formulation of HPV
CN113577244A (en) * 2021-08-09 2021-11-02 高丽莉 Traditional Chinese medicine anti-HPV gel containing biological protein and preparation method thereof
CN114191542A (en) * 2021-12-27 2022-03-18 山东德隆企业管理咨询有限公司 Gel preparation for effectively conditioning and preventing HPV (human papillomavirus) for gynecology and preparation process
CN115715785A (en) * 2022-12-06 2023-02-28 郴州佳明医疗器械有限公司 anti-HPV gel and production process thereof

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CN108096396A (en) * 2018-03-07 2018-06-01 西安璀璨生物科技有限责任公司 A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa

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CN108096396A (en) * 2018-03-07 2018-06-01 西安璀璨生物科技有限责任公司 A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109529015A (en) * 2018-12-12 2019-03-29 上海美哈医药科技有限公司 A kind of women HPV antibacterial agent and preparation method thereof
CN110227060A (en) * 2019-04-29 2019-09-13 广东旭睿美医疗科技有限公司 Containing the anti-HPV gel of giant salamander oligosaccharide peptide
CN110151899A (en) * 2019-06-28 2019-08-23 吴江平 A kind of Chinese medicine draft formula and its fermentation preparation fighting HPV viruse
CN110507816A (en) * 2019-09-20 2019-11-29 江西善行生物科技有限公司 It is a kind of for removing the compound formulation of HPV
CN113577244A (en) * 2021-08-09 2021-11-02 高丽莉 Traditional Chinese medicine anti-HPV gel containing biological protein and preparation method thereof
CN114191542A (en) * 2021-12-27 2022-03-18 山东德隆企业管理咨询有限公司 Gel preparation for effectively conditioning and preventing HPV (human papillomavirus) for gynecology and preparation process
CN115715785A (en) * 2022-12-06 2023-02-28 郴州佳明医疗器械有限公司 anti-HPV gel and production process thereof

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Application publication date: 20181102