CN114191542A - Gel preparation for effectively conditioning and preventing HPV (human papillomavirus) for gynecology and preparation process - Google Patents
Gel preparation for effectively conditioning and preventing HPV (human papillomavirus) for gynecology and preparation process Download PDFInfo
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- CN114191542A CN114191542A CN202111616008.7A CN202111616008A CN114191542A CN 114191542 A CN114191542 A CN 114191542A CN 202111616008 A CN202111616008 A CN 202111616008A CN 114191542 A CN114191542 A CN 114191542A
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Abstract
The invention discloses a gel preparation for effectively conditioning and preventing HPV (human papilloma virus) in gynecology and a preparation process thereof, and relates to the technical field of medicines. The preparation steps are as follows: mixing cleaned fructus Cnidii, radix Sophorae Flavescentis, cortex Phellodendri, Kochiae fructus, folium Artemisiae Argyi and Carthami flos, pulverizing into powder, sieving, adding purified water, heating, filtering, cooling, adding collagen peptide, biological peptide and purified water into the filtrate, heating, filtering, concentrating to obtain extract, mixing the extract with fully dissolved carbomer, Mentholum and methyl hydroxybenzoate, adding purified water, stirring, emulsifying to obtain gel, detecting, packaging, and sealing. The invention has simple preparation process, better prevention and treatment effect on HPV, no toxic or side effect, good inhibition function on HPV virus, capability of enhancing the anti-infection capability and the immunity of human body, good antiviral effect and wide application prospect.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a gel preparation for effectively conditioning and preventing HPV (human papilloma virus) in gynecology and a preparation process thereof.
Background
HPV, namely human papilloma virus, belongs to the genus of papilloma vacuolatum virus A in the family of papovaviridae, is spherical DNA virus, can cause squamous epithelial proliferation of human skin mucosa, and human papilloma virus HPV infection is attracting more and more attention with the rapid increase of incidence rate of pointed condyloma in venereal diseases and the increase of cervical cancer, anal cancer and the like.
The HPV gel can remove human papilloma virus HPV, inhibit herpes simplex virus HSV, prevent various HPV virus invasion and prevent cervical cancer, and has the following effects: (1) aiming at HPV infection, the kit is used for positive transformation to negative transformation of high-risk HPV infection and auxiliary reversal of low-grade cervical lesions. (2) Reestablishes the moist environment of the vagina, forms a reticular structure on the surface of the vagina, locks water and relieves the symptom of vaginal dryness. (3) The vaginal elasticity is restored by exogenously supplementing a large amount of active collagen lost from the vaginal mucosa. (4) Promoting cell metabolism and promoting wound healing.
The prevention and control of HPV virus is of great significance to female physiological health, at present, the prevention and treatment of HPV virus in the prior art are mainly treated by operation, injection and oral medication, but all the methods adopt western medicines, have large side effect on human bodies, have no active prevention means for external use, and the common external medicine for vagina also has no HPV prevention and treatment effect. Based on this, it is particularly necessary to develop a gel preparation for effectively preventing HPV aiming at gynecological conditioning and a preparation process.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the gel preparation for effectively conditioning and preventing HPV in gynecology and the preparation process, the preparation is simple and convenient, the gel preparation has better prevention and treatment effect on HPV, has no toxic or side effect, realizes good inhibition function on HPV virus, enhances the anti-infection capability of human body, and is easy to popularize and use.
In order to achieve the purpose, the invention is realized by the following technical scheme: a gel preparation for effectively conditioning and preventing HPV (human papillomavirus) in gynecology comprises the following raw materials in parts by weight: 1-3 parts of collagen peptide, 2-5 parts of biological peptide, 10-15 parts of fructus cnidii, 5-10 parts of radix sophorae flavescentis, 5-10 parts of cortex phellodendri, 10-20 parts of fructus kochiae, 15-20 parts of folium artemisiae argyi, 2-4 parts of safflower, 2-5 parts of menthol, 0.1-2 parts of carbomer, 0.5-2 parts of methylparaben and 25-35 parts of purified water.
Preferably, the glue preparation consists of the following raw materials in parts by weight: 2-3 parts of collagen peptide, 3-4 parts of biological peptide, 12-14 parts of fructus cnidii, 6-8 parts of radix sophorae flavescentis, 7-9 parts of cortex phellodendri, 14-18 parts of fructus kochiae, 16-18 parts of folium artemisiae argyi, 3-4 parts of safflower, 3-4 parts of menthol, 0.3-1 part of carbomer, 0.6-1 part of methylparaben and 28-32 parts of purified water.
Preferably, the glue preparation consists of the following raw materials in parts by weight: 2 parts of collagen peptide, 3 parts of biological peptide, 13 parts of common cnidium fruit, 7 parts of lightyellow sophora root, 8 parts of amur corktree bark, 15 parts of belvedere fruit, 17 parts of Chinese mugwort leaf, 3 parts of safflower, 4 parts of menthol, 0.5 part of carbomer, 0.8 part of methylparaben and 30 parts of purified water.
A preparation process of a gel preparation for effectively conditioning and preventing HPV (human papillomavirus) in gynecology comprises the following preparation steps: (1) selecting collagen peptide, biological peptide, fructus Cnidii, radix Sophorae Flavescentis, cortex Phellodendri, Kochiae fructus, folium Artemisiae Argyi, Carthami flos, Mentholum, carbomer, methyl hydroxybenzoate and purified water according to corresponding weight parts, and cleaning the medicinal materials;
(2) mixing carbomer with purified water, and swelling carbomer;
(3) mixing cleaned fructus Cnidii, radix Sophorae Flavescentis, cortex Phellodendri, Kochiae fructus, folium Artemisiae Argyi and Carthami flos, and pulverizing into powder by pulverizer;
(4) sieving the pulverized medicinal powder, adding purified water, heating, filtering, and cooling to room temperature;
(5) adding collagen peptide, biological peptide and purified water into the filtrate obtained by filtering, heating again, filtering, and concentrating the obtained filtrate into extract;
(6) mixing the concentrated extract with fully dissolved carbomer, Mentholum, and methyl hydroxybenzoate with purified water, stirring, and emulsifying to obtain gel;
(7) and after the gel is qualified, filling the gel into an administration device, and sealing.
Preferably, the mixing and dissolving time of the carbomer in the step (2) and the purified water is 24 hours.
Preferably, the medicinal material powder in the step (4) is sieved by a sieve with 80-100 meshes; the sieved powder and purified water are dissolved for soaking for 12 hours, and the heating time is 2 hours.
Preferably, the heating time of the filtrate of the step (5), the collagen peptide, the biological peptide and the purified water is 3 hours.
The invention has the beneficial effects that: the invention has simple preparation process, better prevention and treatment effect on HPV, capability of promoting cell metabolism and enhancing the drug absorption capacity of cells, no toxic or side effect, good inhibition function on HPV virus, capability of enhancing the anti-infection capacity and the immunity of human bodies, good antiviral effect and wide application prospect.
Drawings
The invention is described in detail below with reference to the drawings and the detailed description;
FIG. 1 is a flow chart of the preparation of the present invention.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Referring to fig. 1, the following technical solutions are adopted in the present embodiment: a gel preparation for effectively conditioning and preventing HPV (human papillomavirus) in gynecology comprises the following raw materials in parts by weight: 1-3 parts of collagen peptide, 2-5 parts of biological peptide, 10-15 parts of fructus cnidii, 5-10 parts of radix sophorae flavescentis, 5-10 parts of cortex phellodendri, 10-20 parts of fructus kochiae, 15-20 parts of folium artemisiae argyi, 2-4 parts of safflower, 2-5 parts of menthol, 0.1-2 parts of carbomer, 0.5-2 parts of methylparaben and 25-35 parts of purified water.
The rubber preparation is characterized by comprising the following raw materials in parts by weight: 2-3 parts of collagen peptide, 3-4 parts of biological peptide, 12-14 parts of fructus cnidii, 6-8 parts of radix sophorae flavescentis, 7-9 parts of cortex phellodendri, 14-18 parts of fructus kochiae, 16-18 parts of folium artemisiae argyi, 3-4 parts of safflower, 3-4 parts of menthol, 0.3-1 part of carbomer, 0.6-1 part of methylparaben and 28-32 parts of purified water.
The gel of the embodiment specifically comprises the following components:
(1) collagen peptide: is a sensor for cleaning foreign matters by using amoeba cells which are responsible for important functions in the immune action of a body, is very helpful for preventing diseases, can improve the immune function, inhibit cancer cells and activate the cell function, and is also helpful for repairing endometrium.
(2) Biological peptide: has unique biological function, effects of regulating metabolism and physiological function, relieving fatigue, and improving immunity, and has strong activity, diversity, antibacterial and antiviral effects.
(3) Fructus cnidii: has effects in lowering blood pressure, resisting fungi, resisting allergy, killing trichomonas vaginalis, eliminating dampness, dispelling pathogenic wind, killing parasites and relieving itching, and can be used for treating female cold-dampness leukorrhagia, pudendal pruritus, swelling and pain, vulval eczema, female pudendal pruritus, trichomonas vaginitis, etc.
(4) Flavescent sophora root: has antibacterial and anti-inflammatory effects, and also has effect in regulating vaginal flora environment, and can be used for treating cervicitis, trichomonas vaginitis and colpitis mycotica.
(5) Phellodendron bark: has effects in resisting pathogenic microorganism and pathogenic protozoa, clearing away heat, eliminating dampness, relieving fever, relieving inflammation, killing parasites, and relieving itching, and can be used for treating vulvitis, vaginitis, etc.
(6) The preparation method comprises the following steps of (1) preparing broom cypress fruit: clearing away damp-heat, relieving itching, resisting inflammation, promoting urination, and inhibiting immunity, and has certain inhibiting effect on fungi such as Tolypteris ovata, Microsporum ferrugineum, etc.
(7) Folium artemisiae argyi: its stem and leaf contain volatile aromatic oil, and has good antiallergic and antibacterial and antiviral effects, and can be used for treating gynecological diseases such as colpitis mycotica, dysmenorrhea, and leukorrhagia.
(8) Safflower: contains multiple chemical components with therapeutic effect, including flavonoids, polysaccharides, lignans, pigment, volatile oil, dietary fiber, vitamins, trace elements, adenosine, etc., can improve peripheral microcirculation disturbance, improve anoxia resistance, promote blood circulation, remove blood stasis, and relieve stagnation, and has immunity enhancing, antiinflammatory, antioxidant, and antitumor effects.
(9) Menthol: can be applied to skin or mucous membrane to produce cool feeling to relieve discomfort and pain, has effects of cooling and relieving pain, and can be used for external application for diminishing inflammation, relieving pain, relieving itching, and promoting blood circulation.
(10) Carbomer: the cross-linked polymer of acrylic acid with very high relative molecular weight and containing a large amount of carboxyl can sterilize and diminish inflammation, the carbomer resin can generate high-efficiency thickening effect without being influenced by temperature under the condition of low dosage, the traditional Chinese medicine extract can be effectively suspended, and the preparation of gels with wide viscosity range and different rheological properties is facilitated. When the gel is applied to an affected part, carboxyl is reduced and aggregated by carbomer under the acidic environment of the affected part, so that a gel system is damaged, the traditional Chinese medicine extract is quickly released, and the treatment effect is improved.
(11) Methyl paraben: it is effective on various fungi, yeasts and bacteria, and can destroy the cell membrane of microorganism, denature intracellular protein, and inhibit the activity of respiring enzyme system and electron transfer enzyme system of microorganism cell.
The specific embodiment also provides a preparation process of the gel preparation for effectively conditioning and preventing HPV in gynecology, which comprises the following steps: selecting collagen peptide, biological peptide, fructus cnidii, radix sophorae flavescentis, cortex phellodendri, fructus kochiae, folium artemisiae argyi, safflower, menthol, carbomer, methyl paraben and purified water according to corresponding parts by weight, and cleaning the medicinal materials;
mixing carbomer with purified water to fully swell carbomer;
mixing the cleaned fructus cnidii, the radix sophorae flavescentis, the cortex phellodendri, the fructus kochiae, the folium artemisiae argyi and the safflower, and crushing the mixture into powder by a crusher;
sieving the crushed medicinal powder, adding purified water, heating, filtering and cooling to room temperature;
fifthly, adding collagen peptide, biological peptide and purified water into the filtered filtrate, heating again, filtering, and concentrating the obtained filtrate into an extract;
sixthly, the concentrated extract is fully mixed with fully dissolved carbomer, menthol and methyl hydroxybenzoate by adding purified water, stirred uniformly and emulsified to form gel;
seventhly, after the gel is detected to be qualified, the gel is filled into a medicine feeder and sealed.
Preferably, the mixing and dissolving time of the carbomer and the purified water in the step (II) is 24 hours.
Preferably, the powder of the medicinal materials in the step (IV) is sieved by a sieve with 80 to 100 meshes; the sieved powder and purified water are dissolved for soaking for 12 hours, and the heating time is 2 hours.
Preferably, the heating time of the filtrate, the collagen peptide, the bio-peptide and the purified water is 3 hours.
Example 1: a gel preparation for effectively conditioning and preventing HPV (human papillomavirus) in gynecology is composed of the following raw materials in parts by weight: 2 parts of collagen peptide, 3 parts of biological peptide, 13 parts of common cnidium fruit, 7 parts of lightyellow sophora root, 8 parts of amur corktree bark, 15 parts of belvedere fruit, 17 parts of Chinese mugwort leaf, 3 parts of safflower, 4 parts of menthol, 0.5 part of carbomer, 0.8 part of methylparaben and 30 parts of purified water. The preparation method comprises the following steps: selecting collagen peptide, biological peptide, fructus cnidii, radix sophorae flavescentis, cortex phellodendri, fructus kochiae, folium artemisiae argyi, safflower, menthol, carbomer, methyl paraben and purified water according to the parts by weight, and cleaning the medicinal materials;
② mixing 0.5 part of carbomer with 5 parts of purified water for 24 hours to fully swell the carbomer;
thirdly, mixing 13 parts of cleaned fructus cnidii, 7 parts of radix sophorae flavescentis, 8 parts of golden cypress, 15 parts of fructus kochiae, 17 parts of folium artemisiae argyi and 3 parts of safflower, and crushing the mixture into powder by a crusher;
fourthly, sieving the crushed medicinal powder with a 80-mesh sieve, adding 10 parts of purified water, heating for 2 hours, filtering, and cooling to room temperature;
fifthly, adding 2 parts of collagen peptide, 3 parts of biological peptide and 10 parts of purified water into the filtered filtrate, heating for 3 hours again, filtering, and concentrating the obtained filtrate into an extract;
sixthly, the concentrated extract is fully mixed with fully dissolved carbomer, 4 parts of menthol and 0.8 part of methylparaben, 5 parts of purified water, stirred uniformly and emulsified to form gel;
seventhly, after the gel is detected to be qualified, the gel is filled into an administration device and sealed.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (8)
1. The gel preparation for effectively conditioning and preventing HPV (human papillomavirus) in gynecology is characterized by comprising the following raw materials in parts by weight: 1-3 parts of collagen peptide, 2-5 parts of biological peptide, 10-15 parts of fructus cnidii, 5-10 parts of radix sophorae flavescentis, 5-10 parts of cortex phellodendri, 10-20 parts of fructus kochiae, 15-20 parts of folium artemisiae argyi, 2-4 parts of safflower, 2-5 parts of menthol, 0.1-2 parts of carbomer, 0.5-2 parts of methylparaben and 25-35 parts of purified water.
2. The gel preparation for effectively conditioning and preventing HPV in gynecology according to claim 1 is characterized by comprising the following raw materials in parts by weight: 2-3 parts of collagen peptide, 3-4 parts of biological peptide, 12-14 parts of fructus cnidii, 6-8 parts of radix sophorae flavescentis, 7-9 parts of cortex phellodendri, 14-18 parts of fructus kochiae, 16-18 parts of folium artemisiae argyi, 3-4 parts of safflower, 3-4 parts of menthol, 0.3-1 part of carbomer, 0.6-1 part of methylparaben and 28-32 parts of purified water.
3. The gel preparation for effectively conditioning and preventing HPV in gynecology according to claim 1 is characterized by comprising the following raw materials in parts by weight: 2 parts of collagen peptide, 3 parts of biological peptide, 13 parts of common cnidium fruit, 7 parts of lightyellow sophora root, 8 parts of amur corktree bark, 15 parts of belvedere fruit, 17 parts of Chinese mugwort leaf, 3 parts of safflower, 4 parts of menthol, 0.5 part of carbomer, 0.8 part of methylparaben and 30 parts of purified water.
4. A preparation process of a gel preparation for effectively conditioning and preventing HPV (human papillomavirus) in gynecology comprises the following preparation steps: (1) selecting collagen peptide, biological peptide, fructus Cnidii, radix Sophorae Flavescentis, cortex Phellodendri, Kochiae fructus, folium Artemisiae Argyi, Carthami flos, Mentholum, carbomer, methyl hydroxybenzoate and purified water according to corresponding weight parts, and cleaning the medicinal materials;
(2) mixing carbomer with purified water, and swelling carbomer;
(3) mixing cleaned fructus Cnidii, radix Sophorae Flavescentis, cortex Phellodendri, Kochiae fructus, folium Artemisiae Argyi and Carthami flos, and pulverizing into powder by pulverizer;
(4) sieving the pulverized medicinal powder, adding purified water, heating, filtering, and cooling to room temperature;
(5) adding collagen peptide, biological peptide and purified water into the filtrate obtained by filtering, heating again, filtering, and concentrating the obtained filtrate into extract;
(6) mixing the concentrated extract with fully dissolved carbomer, Mentholum, and methyl hydroxybenzoate with purified water, stirring, and emulsifying to obtain gel;
(7) and after the gel is qualified, filling the gel into an administration device, and sealing.
5. The process for preparing a gel formulation effective in preventing HPV for gynecological conditioning according to claim 4, wherein the mixing and dissolving time of the carbomer in the step (2) and the purified water is 24 h.
6. The preparation process of the gel preparation for effectively preventing HPV aiming at gynecological conditioning according to claim 4, wherein the powder of the medicinal material obtained in the step (4) is sieved by a sieve of 80-100 meshes.
7. The preparation process of the gel preparation for effectively preventing HPV in gynecological conditioning according to claim 4, wherein the powder sieved in the step (4) is dissolved in purified water for a soaking time of 12h and heated for a heating time of 2 h.
8. The process for preparing the gel preparation effective in preventing HPV for gynecological conditioning according to claim 4, wherein the heating time of the filtrate of step (5) with collagen peptide, biological peptide and purified water is 3 h.
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