CN103893700B - A kind of Chinese medicine composition treating breast carcinoma - Google Patents
A kind of Chinese medicine composition treating breast carcinoma Download PDFInfo
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Abstract
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine composition treating breast carcinoma and preparation method thereof.Described Chinese medicine composition is prepared from by the crude drug of following weight portion: Radix Notoginseng 15 35 parts, Caulis Sargentodoxae 10 20 parts, Radix Salviae Miltiorrhizae 15 35 parts, Olibanum 15 25 parts, Rhizoma Sparganii 10 20 parts, the Radix Astragali 15 25 parts, Herba Cirsii 5 15 parts, Radix Cyathulae 15 25 parts, Folium Isatidis 5 15 parts, 5 15 parts of Semen Persicae, Spica Prunellae 5 15 parts, Rhizoma Cimicifugae 10 20 parts, Radix Oenotherae erythrosepalae 5 15 parts, Herba Plantaginis 5 15 parts, Concha Arcae 10 20 parts, the Radix Paeoniae Alba 5 15 parts, Rhizoma Cyperi 10 20 parts, Radix Curcumae 10 20 parts, Radix Morindae Officinalis 5 15 parts, Herba Dendrobii 10 20 parts.The present invention treats breast carcinoma effect substantially, has no side effect, difficulty in relapse after healing, and effective percentage reaches 95%, is the ideal medicament for the treatment of breast carcinoma.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine composition treating breast carcinoma and preparation method thereof.
Background technology
Breast carcinoma is one of modal malignant tumor of women, and according to statistics, sickness rate accounts for the various malignant tumor of whole body
7-10%, be that one has a strong impact on the most life-threatening disease of women's physical and mental health.Breast carcinoma refers to that breast duct epithelium is thin
Born of the same parents are under the effect of various inside and outside carcinogenic factors, and cell loses normal characteristic and paraplasm, so that exceeding the limit of self-regeneration
Spend and the disease of canceration occurs.Its performance the earliest is to suffer from breast the most circular, the oval or irregular shape of single-shot, form occur
Little lump, quality is the most harder, indefinite border；A few patients can have distending pain, dull pain.The morbidity of breast carcinoma often has with heredity
Close, and 40-60 year between, women's sickness rate before and after menopause higher.The cause of disease of breast carcinoma is also the clearest and the most definite, but raw
The factors such as situation, oral contraceptive, inherited genetic factors, ionizing radiation, unsound dietary habit of educating have been identified and breast carcinoma
Relevant.The factors such as the most long-term dietary structure, living habit cause body constitution to be excessively acidified, and the overall function of human body declines,
Cause liver of suffering from a deficiency of the kidney the most empty, and then cause part of the body cavity above the diaphragm housing the heart and lungs metabolic cycles slack-off, easily cause thyroid disease and endocrine disturbance, immunity merit
Can decline, thus develop into mammary gland tissue paraplasm, whole carcinogenesis.
The method of existing treatment breast carcinoma is a lot, mainly has operative treatment, chemotherapy and Drug therapy, and these therapies are all paid no attention to
Think.Mammary cancer surgery can cause damage and the QI and blood loss of patient's body tissue, makes patient have a delicate constitution, is easily caused cancer
Recurrence, the diffusion of cancerous cell and transfer.Chemotherapy is one of common method of breast carcinoma non-operative treatment, but it also exists cancerous cell
Be killed together with normal cell, effective dose and toxic dose closely, the wretched insufficiency such as toxic and side effects, wherein with digestion
Function is impaired and hemopoietic function of bone marrow is suppressed waits reaction the most obvious, often makes patient with breast cancer be difficult to connect because reaction is serious
Maybe can not be adhered to the whole course for the treatment of by chemotherapy.
The breast carcinoma traditional Chinese medical science is referred to as breast carcinoma, has another name called milk rock etc., and its pathogeny invades in being mainly positive QI-insufficiency, wind and cold, seven
Feelings internal injury, it is willing to unsuccessful, pent-up impairing the liver, is caused that internal function is disorderly, Chong and Ren channel disorder, reduced the body prison to cancerous cell
Depending on resistance, cause eventually qi stagnation blood stasis when oncogene effect and body's immunity are low, evil poison accumulates interior, the turbid friendship of expectorant and coagulates, and ties stagnant
Breast portion forms.Chinese medicine is the medical advantages that China is exclusive, and Chinese medicine, in treatment breast carcinoma, not only can promote that health is extensive
Multiple, strengthen immunologic function, and antitumaous effect can be played, prevent recurrence and transfer, improve survival rate.Therefore, develop and develop
Effective Chinese medicine preparation treats breast carcinoma, is of great significance the hygiene medical treatment cause tool of China.The present inventor is led to
Cross substantial amounts of experiment to grope, have found a kind of Chinese medicine composition treating breast carcinoma, its pharmacodynamics and clinical experiment effect extremely
Significantly.
Summary of the invention
The present invention is from the rule for the treatment of of Chinese traditional treatment breast carcinoma, through development test, by Radix Notoginseng, Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, breast
Perfume, Rhizoma Sparganii, the Radix Astragali, Herba Cirsii, Radix Cyathulae, Folium Isatidis, Semen Persicae, Spica Prunellae, Rhizoma Cimicifugae, Radix Oenotherae erythrosepalae, Herba Plantaginis, Concha Arcae, the Radix Paeoniae Alba, perfume (or spice)
Attached, Radix Curcumae, Radix Morindae Officinalis, Herba Dendrobii 20 taste medicine, through suitable processing, extraction, be made for the Chinese medicine of a kind of effective treatment breast carcinoma
Compositions.
On the one hand, the present invention provides a kind of Chinese medicine composition treating breast carcinoma, and it is prepared by the raw material of following weight parts
Form: Radix Notoginseng 15-35 part, Caulis Sargentodoxae 10-20 part, Radix Salviae Miltiorrhizae 15-35 part, Olibanum 15-25 part, Rhizoma Sparganii 10-20 part, Radix Astragali 15-25
Part, Herba Cirsii 5-15 part, Radix Cyathulae 15-25 part, Folium Isatidis 5-15 part, Semen Persicae 5-15 part, Spica Prunellae 5-15 part, Rhizoma Cimicifugae 10-20 part,
Radix Oenotherae erythrosepalae 5-15 part, Herba Plantaginis 5-15 part, Concha Arcae 10-20 part, Radix Paeoniae Alba 5-15 part, Rhizoma Cyperi 10-20 part, Radix Curcumae 10-20 part, bar
Halberd sky 5-15 part, Herba Dendrobii 10-20 part.
In a preferred embodiment, described Chinese medicine composition is preferably prepared from by the Chinese medicine of following weight portion:
Radix Notoginseng 25 parts, Caulis Sargentodoxae 15 parts, Radix Salviae Miltiorrhizae 25 parts, Olibanum 20 parts, Rhizoma Sparganii 15 parts, the Radix Astragali 20 parts, Herba Cirsii 10 parts, Radix Cyathulae 20 parts,
Folium Isatidis 10 parts, 10 parts of Semen Persicae, Spica Prunellae 10 parts, Rhizoma Cimicifugae 15 parts, Radix Oenotherae erythrosepalae 10 parts, Herba Plantaginis 10 parts, Concha Arcae 15 parts, the Radix Paeoniae Alba
10 parts, Rhizoma Cyperi 15 parts, Radix Curcumae 15 parts, Radix Morindae Officinalis 10 parts, Herba Dendrobii 15 parts.
On the other hand, the invention provides the preparation method of described Chinese medicine composition, it comprises the steps:
(1) according to the proportioning weighting raw materials Radix Notoginseng of above-mentioned Chinese medicine composition, Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, Olibanum, Rhizoma Sparganii, the Radix Astragali,
Herba Cirsii, Radix Cyathulae, Folium Isatidis, Semen Persicae, Spica Prunellae, Rhizoma Cimicifugae, Radix Oenotherae erythrosepalae, Herba Plantaginis, Concha Arcae, the Radix Paeoniae Alba, Rhizoma Cyperi, Radix Curcumae, Ba Ji
It and Herba Dendrobii, pulverize, mixing for standby use；
(2) crude drug in step (1) is soaked in water that (water did not had powder 3-8cm), after 30-60 minute, intense fire boils,
Slow fire is decocted 30-45 minute, cool down, filter after obtain filtrate and medicinal residues；
(3) by medicinal residues boiling obtained in step (2), amount of water was not to have medicinal residues face 2-5cm, and intense fire boils,
Slow fire is decocted 15-30 minute, cool down, filter after obtain filtrate and filtering residue；
(4) merge twice filtrate and i.e. obtain the Chinese medicine composition of described treatment breast carcinoma.
It is further preferred that the preparation method of Chinese medicine composition of the present invention comprises the steps:
(1) according to the proportioning weighting raw materials Radix Notoginseng of above-mentioned Chinese medicine composition, Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, Olibanum, Rhizoma Sparganii, the Radix Astragali,
Herba Cirsii, Radix Cyathulae, Folium Isatidis, Semen Persicae, Spica Prunellae, Rhizoma Cimicifugae, Radix Oenotherae erythrosepalae, Herba Plantaginis, Concha Arcae, the Radix Paeoniae Alba, Rhizoma Cyperi, Radix Curcumae, Ba Ji
It and Herba Dendrobii, pulverize, mixing for standby use；
(2) be soaked in water (water did not had powder 5cm) after 45 minutes by the crude drug in step (1), and intense fire boils, and slow fire is decocted
40 minutes, cool down, filter after obtain filtrate and medicinal residues；
(3) by medicinal residues boiling obtained in step (2), amount of water was not to have medicinal residues face 5cm, and intense fire boils, literary composition
Fire decoct 25 minutes, cool down, filter after obtain filtrate and filtering residue；
(4) merge twice filtrate and i.e. obtain the Chinese medicine composition of described treatment breast carcinoma.
In a preferred embodiment, can be appropriate auxiliary by adding according to the conventional preparation method in this area
Material, makes the preparations such as tablet, granule, capsule, soft extract, pill, medicinal tea, powder, drop pill by the Chinese medicine composition of the present invention.
Described adjuvant includes the adjuvant that field of medicaments is conventional and general in preparing above-mentioned production process.
Another further aspect, present invention also offers the medical usage of described Chinese medicine composition.The clothes of Chinese medicine composition of the present invention
By method: be decocted in water for oral dose, every day 1 dose, dividing and sooner or later take for twice, serveing on 30 days is a course for the treatment of.Clinic and pharmacological experiment result
Showing, the traditional Chinese medicine composition for treating breast carcinoma effect of the present invention is obvious, has no side effect, and difficulty in relapse after healing, effective percentage reaches
95%.Treatment for breast carcinoma clinically opens new road, has important social value.
In Chinese medicine composition of the present invention, meridian distribution of property and flavor and the effect thereof of each taste Chinese medicine are as follows:
Radix Notoginseng, warm in nature, acrid in the mouth.There is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.Cure mainly spitting of blood, spit blood, epistaxis, have blood in stool, collapse
Leakage, traumatic hemorrhage, chest and abdomen twinge, tumbling down swells and ache.
Caulis Sargentodoxae, nature and flavor are bitter, flat.There is the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide.Dispelling the wind and dampness pathogens arthralgia pain, red
Dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, injury from falling down.
Radix Salviae Miltiorrhizae, bitter in the mouth, feeble QI is trembled with fear, nontoxic.Enter the heart, spleen two warp.There is promoting blood circulation to restore menstrual flow, effect of evacuation of pus granulation promoting, special regulating menstruation
Arteries and veins, manages iliacus and aches, and tissue regeneration promoting blood removes stagnant blood.
Olibanum, arduous, temperature.Enter the heart, liver, spleen channel.There is regulating qi and activating blood, analgesic therapy, chase after effect of poison.Control coagulation of QI-blood, the heart
Abdomen pain, ulcerative carbuncle toxic swelling, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Rhizoma Sparganii, acrid in the mouth, bitter, property is put down.Enter liver, spleen channel.Have blood stasis dispelling stimulate the menstrual flow, removing blood stasis eliminating mass, effect of circulation of qi promoting removing food stagnancy.
The Radix Astragali, sweet, tepor.Return lung, spleen, liver, kidney channel.There is tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, line water detumescence, promoting pus discharge and tissue regeneration strengthening
Effect.
Herba Cirsii, sweet, cool, enter liver, spleen channel.There is effect of removing heat from blood, blood stasis dispelling, hemostasis.Treatment haematemesis, epistaxis, hematuria, blood
Drench, have blood in stool, metrorrhagia, acute infectious hepatitis, wound hemorrhage, furuncle, carbuncle poison.
Radix Cyathulae, hardship sweet, micro-, flat.Return liver, kidney channel.There is eliminating blood stasis and inducing menstruation, easing joint movement, effect of inducing diuresis for treating stranguria syndrome.For
Amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.
Folium Isatidis, bitter, cold.Enter liver, the heart, stomach warp.Heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Treatment epidemic febrile disease intenseness of heat excessive thirst, popularity
Flu, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, haematemesis, epistaxis, jaundice, dysentery, sore throat, mouth
Skin ulcer, swollen ulcer drug.
Semen Persicae, bitter, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.For amenorrhea, bitterly
Warp, abdominal mass mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Spica Prunellae, cold in nature, sweet in the mouth, hardship pungent, micro-, have and let out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, removing heat from blood
Effect of hemostasis, it is adaptable to lymphoid tuberculosis, goiter, acute mastitis, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, blood
Collapse, leukorrhagia, Fiedeler's disease type hepatitis and bacillary dysentery etc..
Rhizoma Cimicifugae, yang invigorating, deliver, rash, removing toxic substances.Control seasonal epidemic pathogens epidemic disease, headache cold and heat, miliaria pruritus due to heat, have sore throat, the toxic swelling that happens suddenly,
Gastric heat toothache, dispute skin ulcer, macule are impermeable, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women is collapsed, uterus drops, carbuncle sore tumefacting virus.
Radix Oenotherae erythrosepalae, bitter in the mouth, micro-pungent, micro-sweet, property is put down.Promoting blood circulation to remove obstruction in the collateral, endogenous wind stopping suppressing the hyperactive liver, detumescence sore.Cure mainly obstruction of qi in the chest and cardialgia, in
Windage yaw paralysis, stirring-up of pathogenic wind in the interior resulting from deficiency, children's many dynamic, wind dampness rheumatic anesthesia pain, stomachache are had loose bowels, dysmenorrhea, oral-anal-genital ulcer syndrome, skin infection, eczema.
Herba Plantaginis, sweet, cold.Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, removing heat from blood, removing toxic substances.Cure mainly accumulation of heat in the urinary bladder, urine
Unfavorable, stranguria with turbid discharge leukorrhagia, heat-damp in summer dysentery, epistaxis, hematuria, liver-heat conjunctival congestion, laryngopharynx swelling and pain, carbuncle sore tumefacting virus.
Concha Arcae, reduces phlegm, softening the hard mass, dissipating blood stasis, removing food stagnancy.Cure mainly accumulation of phlegm, stomachache, acid regurgitation, scrofula, ulcerative gingivitis.
The Radix Paeoniae Alba, cool in nature, bitter in the mouth is sour, be slightly cold.There is the effects such as easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receipts antiperspirant, it is adaptable to the deficiency of YIN
Heating, menoxenia, the chest and abdomen pain over the hypochondriac region, extremity contraction urgency, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.
Rhizoma Cyperi, pungent micro-hardship is sweet, flat.Enter liver, tri-jiao channel.There is resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving, the effect such as antiabortive.Cure mainly the side of body
Rib distending pain, mammary swelling are educated, hernia pain, menoxenia, gastral cavity abdomen feeling of fullness pain, belch acid regurgitation vomiting and nausea, abdominal pain during menstruation, metrorrhagia band
Under, frequent fetal movement.
Radix Curcumae, acrid in the mouth, hardship, cold in nature.Return liver, the heart, lung meridian.There is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, only invigorate blood circulation
Bitterly, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire are used.
Radix Morindae Officinalis, acrid in the mouth, sweet；Slightly warm in nature.Enter spleen, kidney two warp.Reinforcing the kidney and supporting YANG；Bone and muscle strengthening；Expelling wind and removing dampness.Cure mainly: kidney
Empty sexual impotence；Seminal emission premature ejaculation；Cold and pain in the lower abdomen；Incontinence of urine；Cold womb is infertile；Anemofrigid-damp arthralgia；Soreness of the waist and knees；Rheumatism limb gas.
Herba Dendrobii, is slightly cold, sweet, returns stomach, kidney channel.There is effect of reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia
The retch of excessive thirst, lack of appetite, the after being ill disease such as deficiency-heat, poor vision.
Beneficial effects of the present invention:
The present invention is based on the traditional Chinese medical science and treatment breast carcinoma is carried out the dialectical principle treated, and breast carcinoma belongs to Chinese medicine
The category such as " breast painful abdominal mass ", " breast carcinoma ", and be a kind of systemic disease, it is the local clinical performance of general disease.The present invention is various former
Medicine is mutually coordinated can farthest play drug effect together for material, play altogether kidney tonifying qi-restoratives, nourishing blood and promoting blood circulation blood stasis dispelling, removing obstruction in the collateral to relieve pain,
Tumor suppression eliminating stagnation, the merit for the treatment of both the principal and secondary aspects of a disease, it is possible to increase immunity of human body itself, nervous system regulation, and the Chinese medicine composition of the present invention
Human body is not produced any toxic side effects, safely and effectively by thing.Therefore, the present invention is that prior art provides one safely, effectively,
And the Chinese medicine composition for treating breast carcinoma that with low cost, preparation technology is simple and easy to do.
Detailed description of the invention
Technical scheme is further described by implementation below.It is pointed out that following description
It is only the illustration to claimed technical scheme, the not any restriction to these technical schemes.This
The content that bright protection domain is recorded with appended claims is as the criterion.
Embodiment 1
A kind of Chinese medicine composition treating breast carcinoma, it is prepared from by the crude drug of following weight:
Radix Notoginseng 25g, Caulis Sargentodoxae 15g, Radix Salviae Miltiorrhizae 25g, Olibanum 20g, Rhizoma Sparganii 15g, Radix Astragali 20g, Herba Cirsii 10g, Radix Cyathulae 20g,
Folium Isatidis 10g, Semen Persicae 10g, Spica Prunellae 10g, Rhizoma Cimicifugae 15g, Radix Oenotherae erythrosepalae 10g, Herba Plantaginis 10g, Concha Arcae 15g, Radix Paeoniae Alba 10g, perfume (or spice)
Attached 15g, Radix Curcumae 15g, Radix Morindae Officinalis 10g, Herba Dendrobii 15g.
The preparation of described Chinese medicine composition and instructions of taking be: takes the crude drug of above-mentioned weight, pulverizes, mix homogeneously, water
Decoction, potion, divided and sooner or later took for twice, within one month, be a course for the treatment of every day.
The preparation method of described Chinese medicine composition, specifically comprises the following steps that
(1) according to the proportioning weighting raw materials Radix Notoginseng of above-mentioned Chinese medicine composition, Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, Olibanum, Rhizoma Sparganii, the Radix Astragali,
Herba Cirsii, Radix Cyathulae, Folium Isatidis, Semen Persicae, Spica Prunellae, Rhizoma Cimicifugae, Radix Oenotherae erythrosepalae, Herba Plantaginis, Concha Arcae, the Radix Paeoniae Alba, Rhizoma Cyperi, Radix Curcumae, Ba Ji
It and Herba Dendrobii, pulverize, mixing for standby use；
(2) be soaked in water (water covers powder 5cm) after 45 minutes by the crude drug in step (1), and intense fire boils, and slow fire is decocted
40 minutes, cool down, filter after obtain filtrate and medicinal residues；
(3) by medicinal residues boiling obtained in step (2), amount of water was not to have medicinal residues face 5cm, and intense fire boils, literary composition
Fire decoct 25 minutes, cool down, filter after obtain filtrate and filtering residue；
(4) merge twice filtrate and i.e. obtain the Chinese medicine composition of described treatment breast carcinoma.
Embodiment 2
A kind of Chinese medicine composition treating breast carcinoma, it is prepared from by the crude drug of following weight:
Radix Notoginseng 35g, Caulis Sargentodoxae 10g, Radix Salviae Miltiorrhizae 35g, Olibanum 15g, Rhizoma Sparganii 20g, Radix Astragali 15g, Herba Cirsii 15g, Radix Cyathulae 15g,
Folium Isatidis 15g, Semen Persicae 5g, Spica Prunellae 15g, Rhizoma Cimicifugae 10g, Radix Oenotherae erythrosepalae 15g, Herba Plantaginis 5g, Concha Arcae 20g, Radix Paeoniae Alba 5g, Rhizoma Cyperi
20g, Radix Curcumae 10g, Radix Morindae Officinalis 15g, Herba Dendrobii 10g.
The preparation of described Chinese medicine composition and instructions of taking be: takes the crude drug of above-mentioned weight, pulverizes, mix homogeneously, water
Decoction, potion, divided and sooner or later took for twice, within one month, be a course for the treatment of every day.
The preparation method of described Chinese medicine composition, specifically comprises the following steps that
(1) according to the proportioning weighting raw materials Radix Notoginseng of above-mentioned Chinese medicine composition, Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, Olibanum, Rhizoma Sparganii, the Radix Astragali,
Herba Cirsii, Radix Cyathulae, Folium Isatidis, Semen Persicae, Spica Prunellae, Rhizoma Cimicifugae, Radix Oenotherae erythrosepalae, Herba Plantaginis, Concha Arcae, the Radix Paeoniae Alba, Rhizoma Cyperi, Radix Curcumae, Ba Ji
It and Herba Dendrobii, pulverize, mixing for standby use；
(2) be soaked in water (water covers powder 8cm) after 60 minutes by the crude drug in step (1), and intense fire boils, and slow fire is decocted
45 minutes, cool down, filter after obtain filtrate and medicinal residues；
(3) by medicinal residues boiling obtained in step (2), amount of water was not to have medicinal residues face 3cm, and intense fire boils, literary composition
Fire decoct 20 minutes, cool down, filter after obtain filtrate and filtering residue；
(4) merge twice filtrate and i.e. obtain the Chinese medicine composition of described treatment breast carcinoma.
Embodiment 3
A kind of Chinese medicine composition treating breast carcinoma, it is prepared from by the crude drug of following weight:
Radix Notoginseng 15g, Caulis Sargentodoxae 20g, Radix Salviae Miltiorrhizae 15g, Olibanum 25g, Rhizoma Sparganii 10g, Radix Astragali 25g, Herba Cirsii 5g, Radix Cyathulae 25g, big
Folium Isatidis 5g, Semen Persicae 15g, Spica Prunellae 5g, Rhizoma Cimicifugae 20g, Radix Oenotherae erythrosepalae 5g, Herba Plantaginis 15g, Concha Arcae 10g, Radix Paeoniae Alba 15g, Rhizoma Cyperi 10g,
Radix Curcumae 20g, Radix Morindae Officinalis 5g, Herba Dendrobii 20g.
The preparation of described Chinese medicine composition and instructions of taking be: takes the crude drug of above-mentioned weight, pulverizes, mix homogeneously, water
Decoction, potion, divided and sooner or later took for twice, within one month, be a course for the treatment of every day.
The preparation method of described Chinese medicine composition, specifically comprises the following steps that
(1) according to the proportioning weighting raw materials Radix Notoginseng of above-mentioned Chinese medicine composition, Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, Olibanum, Rhizoma Sparganii, the Radix Astragali,
Herba Cirsii, Radix Cyathulae, Folium Isatidis, Semen Persicae, Spica Prunellae, Rhizoma Cimicifugae, Radix Oenotherae erythrosepalae, Herba Plantaginis, Concha Arcae, the Radix Paeoniae Alba, Rhizoma Cyperi, Radix Curcumae, Ba Ji
It and Herba Dendrobii, pulverize, mixing for standby use；
(2) be soaked in water (water covers powder 3cm) after 30 minutes by the crude drug in step (1), and intense fire boils, and slow fire is decocted
30 minutes, cool down, filter after obtain filtrate and medicinal residues；
(3) by medicinal residues boiling obtained in step (2), amount of water was not to have medicinal residues face 2cm, and intense fire boils, literary composition
Fire decoct 15 minutes, cool down, filter after obtain filtrate and filtering residue；
(4) merge twice filtrate and i.e. obtain the Chinese medicine composition of described treatment breast carcinoma.
The anticancer experiment in vitro of embodiment 4 Chinese medicine composition of the present invention
Using classical cytotoxic activity vitro detection method mtt assay, test sample is to the human tumor cells of In vitro culture
Cell proliferation toxicity.
During experiment, sample adds DMSO, is diluted to desired concn by RPMI1640 culture medium, ultrasonic, is partly dissolved, part
Sample solution is suspension, with nutritional solution successively doubling dilution.
Cell strain: MCF-7 Breast Cancer Cell.
Experimental technique:
Experiment uses conventional MTT detection method.Inoculating cell: trophophase cell of taking the logarithm, after the trypsinization of 0.25%
Add the RPMI-1640 culture fluid containing 10% embryo Ox blood serum, cell is diluted to single cell suspension, adjust cell number, inoculation
In 96 orifice plates, every hole 100 μ L.Postvaccinal cell is put 37 DEG C, cultivates 24 hours in 5% CO2 gas incubator.Dosing: will
Test medicine RPMI-1640 culture fluid carries out doubling dilution, altogether 6 concentration of configuration.Survey product liquid, 100 μ are added in 96 orifice plates
L/ hole, each sample concentration sets 4 multiple holes, and matched group sets 5 multiple holes, and sample concentration is 1 × 10-4Mol/L.Matched group is with containing
The RPMI-1640 culture fluid of 10% hyclone supplies residual volume, and making reaction volume is 200 μ L/ holes.After sample-adding, cell is put
37 DEG C, continue in 5% CO2 gas incubator to cultivate 68 hours.Add MTT: abandon supernatant, add MTT5mg/ml, dissolve with PBS, every hole
Add 10 μ L.Put after 37 DEG C of continuation are cultivated 4 hours and take out.Survey OD value: the supernatant in reject 96 orifice plate, every hole adds DMSO 150
μL.Measure OD value in microplate reader 570nm, calculate inhibitory rate of cell growth with following formula:
Suppression ratio=[(1-medication group mean OD value/matched group mean OD value)] × 100%
Experimental result:
Chinese medicine composition prepared by the embodiment 1-3 inhibitory action such as following table to the MCF-7 Breast Cancer Cell of In vitro culture
Shown in:
Table 1
| Embodiment | MCF-7 suppression ratio |
| 1 | 87% |
| 2 | 84% |
| 3 | 80% |
According to above in vitro tests result, Chinese medicine composition prepared by embodiment of the present invention 1-3 is to MCF-7 Breast Cancer Cell
Being respectively provided with significant inhibitory action, its suppression ratio reaches more than 80%.
The embodiment 5 Chinese medicine composition of the present invention inhibitory action to transplanted breast carcinoma
1, laboratory animal and tumor strain
Female Sexual health TA2 mice, body weight 18-22g, Mus 6-8 in age week, purchased from the zoopery of institute of oncology of Jiangsu Province
The heart；Mouse mastopathy cell strain MA-891 is purchased from institute of oncology of Jiangsu Province animal experimental center.
2, modeling and experimental technique
TA2 mice 60, staying 10 the most at random is negative control group, and remaining 50 carry out modeling.Take In vitro culture
Exponential phase MA-891 mouse mastopathy cell, cell concentration is adjusted to l × 107/ml.Under aseptic condition, by MA-891
It is subcutaneous that mouse mastopathy cell is inoculated in the right armpit of TA2 mice, and inoculum concentration is that only (cell number is 2 × 10 to 0.2ml/6/ only).Whole
Individual seeded process must be carried out with sterile working in aseptic cover, completes inoculation in 1h.
6 groups it are randomly divided into, often group 10, respectively tumor model matched group, Chinese medicine composition group (embodiment 1-after inoculation
3), 5-fluorouracil (5-Fu) positive controls and negative control group.After inoculation oncocyte 24h, in test group lumbar injection
Drug composition, dosage is 20mg/kg, negative control group and tumor model matched group equal-volume injection medicine solvent, 5-Fu pair
According to group with normal saline as solvent, dosage is 20mg/kg, each treated animal all by 0.2ml at lumbar injection, successive administration 10d.End
Next day after secondary administration, observe as follows:
Completely stripping tumor mass, and calculating tumor control rate of weighing, tumor control rate=(matched group tumor weight-treatment group swells
Tumor weight)/matched group tumor weight × 100%
3, experimental result:
Chinese medicine composition prepared by the embodiment 1-3 inhibitory action to Implanted breast cancer in mouse: 20mg/kg Chinese medicine composition
Thing can significantly inhibit the growth (P < 0.01) of Implanted breast cancer in mouse, and its anti-breast cancer activity is phonetic higher than chemotherapeutic 5-fluorine urea
Pyridine.It is shown in Table 2.
Table 2
| Group | Dosage | Number of animals | Tumor weight (x ± s) | Tumour inhibiting rate (%) | P value |
| Model control group | 10 | 3.47±0.11 | <0.01 | ||
| 5-Fu | 20mg/kg | 10 | 1.38±0.14 | 60.23% | <0.01 |
| Embodiment 1 | 20mg/kg | 10 | 1.29±0.17 | 62.82% | <0.01 |
| Embodiment 2 | 20mg/kg | 10 | 1.34±0.18 | 61.38% | <0.01 |
| Embodiment 3 | 20mg/kg | 10 | 1.40±0.12 | 59.65% | <0.01 |
The Clinical observation of embodiment 6 Chinese medicine composition of the present invention
Selected from inpatient's totally 120 example with complete data.It is randomly divided into treatment group 60 example, matched group 60 example.Treatment
Group the age be 35-60 year, 47.5 years old mean age, the matched group age 32-59 year, 45.5 years old mean age, the age without statistics
Learn significant difference (P > 0.05).
Diagnostic criteria:
Western medicine diagnose standard: touch lump, matter in breast firmly, touch less than obvious lump in air spots or breast, but sick
Reason or cytolgical examination have found cancerous cell, all can be diagnosed as breast carcinoma.
Tcm diagnosis standard:
Syndrome Differentiation of Traditional Chinese Medicine
1. caused by hepatic stagnation qi stagnation: see lump in breast, matter is hard, and the colour of skin is constant；Feelings will is not smooth, vexed poor appetite, feeling of oppression over the chest and distention of hypochondrium, warp
Front mammary swelling, the dark yellow fur of tongue, stringy pulse or stringy and thready pulse.
2. spleen emptiness and wet sputum type: breast lumps, and matter is the most uneven, and there are core, shallow complexion, spiritlessness and weakness in oxter, and gastral cavity uncomfortable in chest is swollen,
Anorexia loose stool, pale tongue has indentation, and tongue is the most greasy, and rolling pulse is thin.
3. Chong and Ren channel disorder type: common disorderly through thing, premenstrual distending pain of the breast, above the average age for marriage unmarried or do not give birth to after marriage or gave birth to
Many, or repeatedly miscarry, or non-suckling in puerperal, lump in breast is hard, pale tongue with thin fur, stringy and thready pulse.
4. ecchymosis internal resistance type: there is block in Ruzhong, quality is hard, scorching hot pain, and the colour of skin is purple dark, and boundary is unclear, and push away is motionless,
Or lump ulceration, seepage flow blood or yellow fluid, the smelly pain of taste；Unhappy irritability, difference of sleeping of having a headache, xerostomia happiness drink, dry stool yellowish urine, purplish tongue is dark,
Or having an ecchymosis, yellow fur is thick and dry, deep and hesitant pulse or stringy and rapid pulse.
5. QI and blood is double loses type: there is block in Ruzhong, is uneven, and seemingly such as heap foxtail millet, bursts after first corruption, and Tianjin during sewage is hemorrhage the most smelly,
Dizzy margins of eyelids, heart beating breathes hard, waist soreness, and hyperhidrosis is slept difference, urinates clear loose stool, pale tongue with white fur, deep-thready pulse.
Therapeutic Method:
Treatment group takes the Chinese medicine composition of embodiment 1, and every day, potion, took at twice sooner or later, and a course for the treatment of is 30 days,
Take two courses for the treatment of continuously.
Matched group uses CMF scheme, CTX-cyclophosphamide；MTX-methotrexate；5-fluorouracil (5-Fu).CTX600 milli
Gram, intravenous.MTX15 milligram, intravenous.5-Fu500 milligram, vein drips past.First inject MTX, after 6 hours, inject CTX and 5-Fu again,
To obtain drug synergism.Often within 7-10 days, it is administered once, treats two months.
Efficacy assessment standard:
Chemotherapeutic efficacy standard is drafted with reference to national breast carcinoma meeting in 1987:
Disappear (CR) the most entirely: all cancer seen of looking into are wholly absent, and osteolytic lesion is whole calcifications on x-ray；
2. partial disappearance (PR): pathological changes can be measured and reduce 50% (products of 2 maximum perpendicular diameters of axle), simultaneously without new focus
Occur, but do not require that all focuses all belong to PR.
3. stable without becoming (S): tumor regression < 50%, or increase < 25%.
4. deteriorate (PD): some focus reduces<50%, simultaneously some focus increase>25%, or all focuses increase, or
New focus is had to occur.
Therapeutic outcome: two groups of therapeutic outcomes are as shown in table 3:
Table 3
| Group | Number | CR/ example | PR/ example | S/ example | PD/ example | Effective percentage |
| Treatment group | 60 | 23 | 22 | 12 | 3 | 95% |
| Matched group | 60 | 17 | 14 | 14 | 15 | 75.0% |
Through X 2 test, two groups of effective percentage compare, and difference has very significant (P < 0.01)
Model case
Single certain, 47 years old.Lump in breast is found the year before at Hospital Physical Examination, without obvious pain, also aperiodicity change, quality
Hard such as rock, mobility is poor.It is right breast carcinoma through hospital diagnosis, patient's emaciated physique, dim complexion, fatigue and weakness.Disease see through
Thing is disorderly, and premenstrual distending pain of the breast, lump in breast is hard, pale tongue, white and thin fur, stringy and thready pulse.Take the Chinese medicine of the embodiment of the present invention 1
1 course for the treatment of of compositions, the premenstrual distending pain of the breast of patient has alleviated, and sleep improves.The Chinese medicine composition of the following the service embodiment of the present invention 1
2 courses for the treatment of, the premenstrual distending pain of the breast of patient disappears, and menstrual cycle is normal, and lump in breast reduces earlier above.Following the service Chinese medicine composition of the present invention
1 course for the treatment of of thing, lump in breast disappears, and all diseases are all removed, and examination in hospital is without difference.Following up a case by regular visits to 1 year, health is good.
Zhu, 50 years old, left breast top outward found a lump about 3 × 3.5cm, and matter is hard, rough, surrounding is not advised
Then, hospital diagnosis is breast carcinoma.Disease sees left arm distending pain, the most slightly feels numb, shallow complexion, tired mind, thin and greasy fur, arteries and veins
String.Taking 1 course for the treatment of of Chinese medicine composition of the embodiment of the present invention 1, patient's appetite increases, and sleep improves, and all diseases all have alleviation.Continue
Taking 2 courses for the treatment of of Chinese medicine composition of the present invention, patient's left breast mass reduction, left arm distending pain, pain and numbness disappear.In the following the service present invention
1 course for the treatment of of drug composition, after treatment, abnormal all diseases disappear substantially, and the index of tumor is the most normal.Following up a case by regular visits to 1 year, health is good.
Zhao so-and-so, 38 years old, the existing lump of 2 years front left suppurative mastitis, was breast carcinoma through hospital diagnosis, and patient takes the present invention and implements
Two courses for the treatment of of the Chinese medicine composition of example 1, lump progressively diminishes, and after 2 courses for the treatment of of continuing to take medicine, lump is wholly absent, examination in hospital
Without difference.Following up a case by regular visits to 1 year, health is good.
Present invention merely illustrates some claimed specific embodiments, one of them or more skill
Technical characteristic described in art scheme can be combined with arbitrary one or more technical schemes, and these are combined and obtain
Technical scheme also in the application protection domain, combined just as these and the technical scheme that obtains is open in the present invention
In content as concrete record.
Claims (7)
1. treating a Chinese medicine composition for breast carcinoma, it is prepared from by the crude drug of following weight portion: Radix Notoginseng 15-35 part,
Caulis Sargentodoxae 10-20 part, Radix Salviae Miltiorrhizae 15-35 part, Olibanum 15-25 part, Rhizoma Sparganii 10-20 part, Radix Astragali 15-25 part, Herba Cirsii 5-15 part, river cattle
Knee joint 15-25 part, Folium Isatidis 5-15 part, Semen Persicae 5-15 part, Spica Prunellae 5-15 part, Rhizoma Cimicifugae 10-20 part, Radix Oenotherae erythrosepalae 5-15 part, Herba Plantaginis
Grass 5-15 part, Concha Arcae 10-20 part, Radix Paeoniae Alba 5-15 part, Rhizoma Cyperi 10-20 part, Radix Curcumae 10-20 part, Radix Morindae Officinalis 5-15 part, Herba Dendrobii
10-20 part.
Chinese medicine composition the most according to claim 1, it is preferably prepared from by the crude drug of following weight portion: Radix Notoginseng 25
Part, Caulis Sargentodoxae 15 parts, Radix Salviae Miltiorrhizae 25 parts, Olibanum 20 parts, Rhizoma Sparganii 15 parts, the Radix Astragali 20 parts, Herba Cirsii 10 parts, Radix Cyathulae 20 parts, Folium Isatidis
10 parts, 10 parts of Semen Persicae, Spica Prunellae 10 parts, Rhizoma Cimicifugae 15 parts, Radix Oenotherae erythrosepalae 10 parts, Herba Plantaginis 10 parts, Concha Arcae 15 parts, the Radix Paeoniae Alba 10 parts,
Rhizoma Cyperi 15 parts, Radix Curcumae 15 parts, Radix Morindae Officinalis 10 parts, Herba Dendrobii 15 parts.
3. a preparation method for the Chinese medicine composition described in claim 1 or 2, it comprises the steps:
(1) according to the proportioning weighting raw materials Radix Notoginseng of Chinese medicine composition, Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, Olibanum, Rhizoma Sparganii, the Radix Astragali, Herba Cirsii, river
Radix Achyranthis Bidentatae, Folium Isatidis, Semen Persicae, Spica Prunellae, Rhizoma Cimicifugae, Radix Oenotherae erythrosepalae, Herba Plantaginis, Concha Arcae, the Radix Paeoniae Alba, Rhizoma Cyperi, Radix Curcumae, Radix Morindae Officinalis and stone
Dry measure used in former times, pulverizes, mixing for standby use；
(2) being soaked in water by the crude drug in step (1), water did not had powder 3-8cm, and after 30-60 minute, intense fire boils, slow fire
Decoct 30-45 minute, cool down, filter after obtain filtrate and medicinal residues；
(3) by medicinal residues boiling obtained in step (2), amount of water did not had medicinal residues face 2-5cm, and intense fire boils, and slow fire is decocted
15-30 minute, cool down, filter after obtain filtrate and filtering residue；
(4) merge twice filtrate and i.e. obtain the Chinese medicine composition treating breast carcinoma.
The preparation method of Chinese medicine composition the most according to claim 3, its step includes:
(1) according to the proportioning weighting raw materials Radix Notoginseng of Chinese medicine composition, Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, Olibanum, Rhizoma Sparganii, the Radix Astragali, Herba Cirsii, river
Radix Achyranthis Bidentatae, Folium Isatidis, Semen Persicae, Spica Prunellae, Rhizoma Cimicifugae, Radix Oenotherae erythrosepalae, Herba Plantaginis, Concha Arcae, the Radix Paeoniae Alba, Rhizoma Cyperi, Radix Curcumae, Radix Morindae Officinalis and stone
Dry measure used in former times, pulverizing, mixing for standby use；
(2) being soaked in water by the crude drug in step (1), water did not had powder 5cm, and after 45 minutes, intense fire boils, and slow fire decocts 40 points
Clock, cool down, filter after obtain filtrate and medicinal residues；
(3) by medicinal residues boiling obtained in step (2), amount of water did not had medicinal residues face 5cm, and intense fire boils, and slow fire decocts 25
Minute, cool down, filter after obtain filtrate and filtering residue；
(4) merge twice filtrate and i.e. obtain the Chinese medicine composition of described treatment breast carcinoma.
5. the pharmaceutical preparation containing the Chinese medicine composition described in claim 1 or 2, it is characterised in that by described Chinese drug-treated group
Compound and pharmaceutically acceptable adjuvant are prepared as tablet, granule, capsule, soft extract, pill, medicinal tea, powder.
Pharmaceutical preparation the most according to claim 5, it is characterised in that described pharmaceutical preparation is tablet or granule.
7. the application in the medicine of preparation treatment breast carcinoma of the Chinese medicine composition described in claim 1 or 2.
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| CN101670071A (en) * | 2009-09-25 | 2010-03-17 | 卢速江 | Traditional Chinese medicine preparation for treating cancer and preparation method thereof |
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