CN103690902B - For preventing the Chinese medicine preparation of nasopharyngeal carcinoma radiation side reaction - Google Patents

Abstract

The invention provides a kind ofly for preventing the Chinese medicine preparation of nasopharyngeal carcinoma radiation side reaction, its bulk drug comprises wilsonii, Radix Codonopsis, the fruit of glossy privet, blackberry lily, coix seed, the stem of noble dendrobium, the coptis, cordate houttuynia, the wind-weed, madder, caulis bambusae in taenian, hairyvein agrimony, Radix Angelicae Sinensis, the radix paeoniae rubrathe, chrysanthemum, curcuma zedoary, Selaginella tamariscina, radix pseudostellariae, yncaria stem with hooks, Chinese yam, mountain wax plum, wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, franzenbach rhubarb root and rhizome, date, the seed of Chinese dodder, aleppo avens, sealwort, radix ranunculi ternati, parasitic loranthus, Japanese cryptotaenia stem and leaf and caulis lonicerae. This Chinese medicine preparation curative effect is good, have no side effect, can be used as the adjuvant therapy medicaments of nasopharyngeal carcinoma tumor chemoradiotherapy, Nasopharyngeal Carcinoma Patients Miles' operation uses, to strengthening the curative effect of chemicotherapy and alleviating the side reaction after radiotherapy and improve life quality by of great advantage, simultaneously also for the complex treatment of malignant tumour has represented good prospect.

Description

For preventing the Chinese medicine preparation of nasopharyngeal carcinoma radiation side reaction

Technical field

The present invention relates to traditional Chinese medicine technical field, relate in particular to a kind of for preventing nasopharyngeal carcinoma radiationThe Chinese medicine preparation of side reaction.

Background technology

Nasopharyngeal carcinoma is the head and neck neoplasm occurred frequently of south China and Asia Chinese ethnic group. The cause of disease and Epstein-Barr virusThe factors such as infection, heredity and environmental pollution are relevant, and radiotherapy is current effective first-selected methods for the treatment of,5～10 years survival rates of single radiotherapy means treatment Advanced Nasopharyngeal Carcinoma case only have 40% left and right, and changeLearning medicine synchronous therapeutic III/IV phase nasopharyngeal carcinoma has become the standard method that improves curative effect, adopt at present morePlatinum class is main treated with combined medication, and chemicotherapy therapeutic alliance can improve survival rate, reduces local recurrence and fallLow DISTANT METASTASES IN incidence.

Although Miles' operation treatment curative effect is certain, relevantization, the increase of radiotherapy toxicity are also sure,Because acute toxic reaction increases the unplanned property of its radiotherapy TD, often affect the treatment, simultaneously medicine poisonProperty summation action has also affected life in patients, although it is high particularly to adopt at present accurate radiotherapy to reduceThe damage of danger organ, but radiotherapy mucosa injury is because dose relationship increases, and particularly adds and makes III/ by chemotherapyThe operability of putting of IV phase nasopharyngeal carcinoma synchronous therapeutic is affected. Therefore, how to improve side reaction and carryThe operability of high scheme, and make life quality improve the important directions that has become nasopharyngeal carcinoma research.

The side reaction of nasopharyngeal carcinoma not only affects the continuity of patients ' life quality, treatment, when seriousEven jeopardize patient's life. The idea of therapy of combing traditional Chinese and Western medicine tumour is generally accepted and has been obtained at presentSure effect, nose because of cancer chemicotherapy process coordinate Chinese medicine can improve patient's symptom, alleviate put,Chemotherapy side effect, improves patients ' life quality, strengthens the confidence of patient's continual cure.

Nasopharyngeal carcinoma belongs to the categories such as traditional Chinese medicine " mistake is flourish ", " glanders ", " nasosinusitis ", " subcutaneous ulcer of dying young ",Radioactive ray are as the hot kill agent of one, and damage oral cavity, throat mucous membrane and salivary gland, be equivalent to traditional Chinese medical science instituteMeaning heat evil is invaded, inside and outside heat poison, and beset by troubles combination, changes the bright Tianjin of fire, first occurs the symptom of body fluid being damaged,Along with the increase of exit dose, the hot malicious stasis of blood is long-pending, and " heat evil easily causes sore ", mucous membrane of mouth part or skin are glutinousFilm ulcer is suppurated, hurt like hell, and with the passing of time heat evil damages healthy tendency, thereby causes the human body gas deficiency of Yin, local TianjinLiquid deficiency, often show as clinically one yin asthenia generating intrinsic heat such as dry, dry throat pain, dysphagia itResemble. " institute of heresy gathers, and its gas must be empty ", therefore the basic pathogenesis " deficiency of Yin after Radiotherapy for Nasopharyngeal CarcinomaFor this, dryness evil is mark ", hot malicious phlegm stasis of blood cohesion, healthy tendency is impaired, body ressitance weakened while pathogenic factors prevailing run through disease all the time,It is dirty that pathology can relate to lung, spleen, stomach three.

Traditional Chinese medicine thinks that nasopharyngeal carcinoma polyphyly phlegm, poison, heat pents up, and radiotherapy is high strong method of attacking heresy, putsSide reaction after treatment belongs to " hot poison pents up " category more, clinical mainly with nourishing Yin and clearing heat for treatment large method. ButThere is the tongue of some patients were not red or red deep red, and see greasy and thin fur, Ye Hui main suit's dry, this is due to patientElement body weakness, prolonged illness injures taste, failure of the spleen to transport and transform, body fluid can not normal defeated cloth causes. Therefore controlCan not be simply taking nourishing Yin and clearing heat removing toxic substances as method on treating, and should show according to patient clinical diagnosis and treatment based on an overall analysis of the illness and the patient's condition. SpleenFor the source of vital function day after tomorrow, therefore strengthening the spleen and replenishing qi, nourishing the stomach to improve the production of body fluid occupy critical role equally.

The present invention, taking nourishing Yin and clearing heat removing toxic substances, strengthening the spleen and replenishing qi nourishing the stomach as principle of reatment, provides a kind of for preventionThe Chinese medicine preparation of nasopharyngeal carcinoma radiation side reaction, its curative effect is good, has no side effect, and can be used asThe adjuvant therapy medicaments of nasopharyngeal carcinoma tumor chemoradiotherapy, nose, because of the use of cancer patient Miles' operation, is put strengtheningThe curative effect of chemotherapy and alleviate the side reaction after radiotherapy and improve life quality by of great advantage, simultaneously also for dislikingThe complex treatment of property tumour has represented good prospect.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of for preventing nasopharyngeal carcinoma radiation secondary anti-The Chinese medicine preparation of answering, its curative effect is good, has no side effect, and can be used as the auxiliary of nasopharyngeal carcinoma tumor chemoradiotherapyHelp medicine, Nasopharyngeal Carcinoma Patients Miles' operation uses, to strengthening the curative effect of chemicotherapy and alleviating radiotherapyAfter side reaction and improve life quality by of great advantage, simultaneously also for the complex treatment of malignant tumour representsGood prospect.

For solving the problems of the technologies described above, the invention provides a kind of for preventing nasopharyngeal carcinoma radiation secondaryThe Chinese medicine preparation of reaction, its bulk drug comprises wilsonii, Radix Codonopsis, the fruit of glossy privet, blackberry lily, coix seed, stoneDry measure used in former times, the coptis, cordate houttuynia, the wind-weed, madder, caulis bambusae in taenian, hairyvein agrimony, Radix Angelicae Sinensis, the radix paeoniae rubrathe, chrysanthemum, curcuma zedoary,Selaginella tamariscina, radix pseudostellariae, yncaria stem with hooks, Chinese yam, mountain wax plum, wood indigo plant, meadow fescue, eleusine indica, white wine grass, unitPrecious grass, franzenbach rhubarb root and rhizome, date, the seed of Chinese dodder, aleppo avens, sealwort, radix ranunculi ternati, parasitic loranthus, Japanese cryptotaenia stem and leaf andCaulis lonicerae.

Wherein, in described Chinese medicine preparation, the weight of each bulk drug is respectively wilsonii 55g～65g, Radix Codonopsis70g～80g, fruit of glossy privet 45g～55g, blackberry lily 30g～40g, coix seed 25g～35g, stem of noble dendrobium 30g～40g, coptis 55g～65g, cordate houttuynia 25g～35g, wind-weed 30g～40g, madder 30g～40g, bambooEat 25g～35g, hairyvein agrimony 35g～45g, Radix Angelicae Sinensis 20g～30g, radix paeoniae rubrathe 30g～40g, chrysanthemum 35g～45g, curcuma zedoary 25g～35g, Selaginella tamariscina 30g～40g, radix pseudostellariae 35g～45g, yncaria stem with hooks 30g～40g, mountainMedicine 20g～30g, mountain wax plum 25g～35g, wooden blue 25g～35g, meadow fescue 30g～40g, eleusine indica25g～35g, white wine grass 30g～40g, Samson St Johswort 15g～25g, franzenbach rhubarb root and rhizome 20g～30g, date 20g～30g, seed of Chinese dodder 30g～40g, aleppo avens 40g～50g, sealwort 30g～40g, radix ranunculi ternati 25g～35g,Parasitic loranthus 20g～30g, Japanese cryptotaenia stem and leaf 25g～35g and caulis lonicerae 15g～25g.

Wherein, in described Chinese medicine preparation the weight of each component be respectively wilsonii 60g～65g, Radix Codonopsis 75g～80g, fruit of glossy privet 50g～55g, blackberry lily 35g～40g, coix seed 30g～35g, stem of noble dendrobium 35g～40g,Coptis 60g～65g, cordate houttuynia 30g～35g, wind-weed 35g～40g, madder 35g～40g, caulis bambusae in taenian 30g～35g, hairyvein agrimony 40g～45g, Radix Angelicae Sinensis 20g～25g, radix paeoniae rubrathe 30g～35g, chrysanthemum 35g～40g, cowherbArt 25g～30g, Selaginella tamariscina 30g～35g, radix pseudostellariae 35g～40g, yncaria stem with hooks 30g～35g, Chinese yam 20g～25g, mountain wax plum 25g～30g, wooden blue 25g～30g, meadow fescue 30g～35g, eleusine indica 25g～30g,White wine grass 30g～35g, Samson St Johswort 15g～20g, franzenbach rhubarb root and rhizome 20g～25g, date 20g～25g, TuSilk 30g～35g, aleppo avens 40g～45g, sealwort 30g～35g, radix ranunculi ternati 30g～35g, mulberry are postedRaw 20g～25g, Japanese cryptotaenia stem and leaf 30g～35g and caulis lonicerae 20g～25g.

Wherein, in described Chinese medicine preparation, the weight of each component is respectively wilsonii 60g, Radix Codonopsis 75g, glossy privetSub-50g, blackberry lily 35g, coix seed 30g, stem of noble dendrobium 35g, coptis 60g, cordate houttuynia 30g, wind-weed 35g,Madder 35g, caulis bambusae in taenian 30g, hairyvein agrimony 40g, Radix Angelicae Sinensis 25g, radix paeoniae rubrathe 35g, chrysanthemum 40g, curcuma zedoary 30g,Selaginella tamariscina 35g, radix pseudostellariae 40g, yncaria stem with hooks 35g, Chinese yam 25g, mountain wax plum 30g, wooden blue 30g, meadow fescue35g, eleusine indica 30g, white wine grass 35g, Samson St Johswort 20g, franzenbach rhubarb root and rhizome 25g, date 25g, the seed of Chinese dodder35g, aleppo avens 45g, sealwort 35g, radix ranunculi ternati 30g, parasitic loranthus 25g, Japanese cryptotaenia stem and leaf 30g and caulis lonicerae20g。

Wherein, described Chinese medicine preparation can be prepared into capsule and oral liquid.

It is above-mentioned for preventing the Traditional Chinese medicine preparation capsule of nasopharyngeal carcinoma radiation side reaction that the present invention also providesThe preparation method of agent, is specially:

The first step, by blackberry lily, the coptis, cordate houttuynia, the wind-weed, caulis bambusae in taenian, hairyvein agrimony, chrysanthemum, mountain wax plum,Wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, radix ranunculi ternati, Japanese cryptotaenia stem and leaf and caulis lonicerae powder respectivelyBroken, mix in proportion, obtain mixture, add the water doubly with respect to mixture quality 7-9, soak 3-5After hour, distill 3-5 hour, collect volatile oil, the dregs of a decoction are for subsequent use;

Second step, pulverizes remaining component respectively, puts into continuous extraction and fills with, then add the first step to obtainThe dregs of a decoction, adding determining alcohol is the alcohol extract 3-5 hour of 70%-80%, described in the amount of alcohol adding isDoubly, extract filters the 3-5 of the each bulk drug quality of Chinese medicine preparation sum, and filtrate is concentrated into relative density and isThe lotion of 1.25～1.30 (65 DEG C), lets cool;

The 3rd step, gets the above-mentioned lotion of 500g, adds the excipient starch of 1kg-2kg to be mixed into softwood, mistakeSieve series grain and in 55-65 DEG C dry, after whole grain, obtain particle, then the volatile oil that adds the first step to obtain,Encapsulated.

It is above-mentioned for preventing the Chinese medicine preparation of nasopharyngeal carcinoma radiation side reaction oral that the present invention also providesThe preparation method of liquid, is specially:

The first step, by blackberry lily, the coptis, cordate houttuynia, the wind-weed, caulis bambusae in taenian, hairyvein agrimony, chrysanthemum, mountain wax plum,Wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, radix ranunculi ternati, Japanese cryptotaenia stem and leaf and caulis lonicerae powder respectivelyBroken, mix in proportion, obtain mixture, add the water doubly with respect to mixture quality 7-9, soak 3-5After hour, distill 3-5 hour, collect volatile oil, the dregs of a decoction are for subsequent use;

Second step, pulverizes remaining component respectively, puts into continuous extraction and fills with, then add the first step to obtainThe dregs of a decoction, extracting in water 3-5 hour, the water yield adding be the each bulk drug quality of described Chinese medicine preparation itWith 6-8 doubly, extract filters, and is concentrated into relative density 1.10-1.12 (60 DEG C), static 24 hours,Get supernatant and reclaim ethanol and be concentrated into relative density 1.04 (20 DEG C), leave standstill 48 hours, get supernatant filterCross, volatile oil, Tween-80 and appropriate flavouring that filtrate adds the first step to prepare, adjust volume extremely1000ml, filters, packing, and sterilizing, obtains described oral liquid.

It is a kind of for preventing the Traditional Chinese medicine preparation capsule of nasopharyngeal carcinoma radiation side reaction that the present invention also providesAgent, its bulk drug comprises wilsonii, Radix Codonopsis, the fruit of glossy privet, blackberry lily, coix seed, the stem of noble dendrobium, the coptis, fishRaw meat grass, the wind-weed, madder, caulis bambusae in taenian, hairyvein agrimony, Radix Angelicae Sinensis, the radix paeoniae rubrathe, chrysanthemum, curcuma zedoary, Selaginella tamariscina, crown princeGinseng, yncaria stem with hooks, Chinese yam, mountain wax plum, wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, mountain are largeHuang, date, the seed of Chinese dodder, aleppo avens, sealwort, radix ranunculi ternati, parasitic loranthus, Japanese cryptotaenia stem and leaf and caulis lonicerae;

The preparation method of described capsule is specially,

The first step, by blackberry lily, the coptis, cordate houttuynia, the wind-weed, caulis bambusae in taenian, hairyvein agrimony, chrysanthemum, mountain wax plum,Wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, radix ranunculi ternati, Japanese cryptotaenia stem and leaf and caulis lonicerae powder respectivelyBroken, mix in proportion, obtain mixture, add the water doubly with respect to mixture quality 7-9, soak 3-5After hour, distill 3-5 hour, collect volatile oil, the dregs of a decoction are for subsequent use;

Second step, pulverizes remaining component respectively, puts into continuous extraction and fills with, then add the first step to obtainThe dregs of a decoction, adding determining alcohol is the alcohol extract 3-5 hour of 70%-80%, described in the amount of alcohol adding isDoubly, extract filters the 3-5 of the each bulk drug quality of Chinese medicine preparation sum, and filtrate is concentrated into relative density and isThe lotion of 1.25～1.30 (65 DEG C), lets cool;

The 3rd step, gets the above-mentioned lotion of 500g, adds the excipient starch of 1kg-2kg to be mixed into softwood, mistakeSieve series grain and in 55-65 DEG C dry, after whole grain, obtain particle, then the volatile oil that adds the first step to obtain,Encapsulated.

It is a kind of for preventing the Chinese medicine preparation of nasopharyngeal carcinoma radiation side reaction oral that the present invention also providesLiquid, its bulk drug comprises wilsonii, Radix Codonopsis, the fruit of glossy privet, blackberry lily, coix seed, the stem of noble dendrobium, the coptis, fishRaw meat grass, the wind-weed, madder, caulis bambusae in taenian, hairyvein agrimony, Radix Angelicae Sinensis, the radix paeoniae rubrathe, chrysanthemum, curcuma zedoary, Selaginella tamariscina, crown princeGinseng, yncaria stem with hooks, Chinese yam, mountain wax plum, wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, mountain are largeHuang, date, the seed of Chinese dodder, aleppo avens, sealwort, radix ranunculi ternati, parasitic loranthus, Japanese cryptotaenia stem and leaf and caulis lonicerae;

The preparation method of described Chinese medicine preparation oral liquid is specially,

The first step, by blackberry lily, the coptis, cordate houttuynia, the wind-weed, caulis bambusae in taenian, hairyvein agrimony, chrysanthemum, mountain wax plum,Wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, radix ranunculi ternati, Japanese cryptotaenia stem and leaf and caulis lonicerae powder respectivelyBroken, mix in proportion, obtain mixture, add the water doubly with respect to mixture quality 7-9, soak 3-5After hour, distill 3-5 hour, collect volatile oil, the dregs of a decoction are for subsequent use;

Second step, pulverizes remaining component respectively, puts into continuous extraction and fills with, then add the first step to obtainThe dregs of a decoction, extracting in water 3-5 hour, the water yield adding be the each bulk drug quality of described Chinese medicine preparation itWith 6-8 doubly, extract filters, and is concentrated into relative density 1.10-1.12 (60 DEG C), static 24 hours,Get supernatant and reclaim ethanol and be concentrated into relative density 1.04 (20 DEG C), leave standstill 48 hours, get supernatant filterCross, volatile oil, Tween-80 and appropriate flavouring that filtrate adds the first step to prepare, adjust volume extremely1000ml, filters, packing, and sterilizing, obtains described oral liquid.

Beneficial effect of the present invention:

Chinese medicine preparation curative effect provided by the invention is good, has no side effect, and can be used as nasopharyngeal carcinoma tumour and putsThe adjuvant therapy medicaments of chemotherapy, Nasopharyngeal Carcinoma Patients Miles' operation use, to strengthen chemicotherapy curative effect andAlleviate the side reaction after radiotherapy and improve life quality by of great advantage, be also the comprehensive of malignant tumour simultaneouslyTreatment has represented good prospect.

Detailed description of the invention

The invention provides a kind ofly for preventing the Chinese medicine preparation of nasopharyngeal carcinoma radiation side reaction, it is formerMaterial cartridge bag is drawn together wilsonii, Radix Codonopsis, the fruit of glossy privet, blackberry lily, coix seed, the stem of noble dendrobium, the coptis, cordate houttuynia, is knownMother, madder, caulis bambusae in taenian, hairyvein agrimony, Radix Angelicae Sinensis, the radix paeoniae rubrathe, chrysanthemum, curcuma zedoary, Selaginella tamariscina, radix pseudostellariae, yncaria stem with hooks,Chinese yam, mountain wax plum, wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, franzenbach rhubarb root and rhizome, date,The seed of Chinese dodder, aleppo avens, sealwort, radix ranunculi ternati, parasitic loranthus, Japanese cryptotaenia stem and leaf and caulis lonicerae.

Further, described Chinese medicine preparation is only made up of above-mentioned raw materials medicine.

In described Chinese medicine preparation the weight of each bulk drug be respectively wilsonii 55g～65g, Radix Codonopsis 70g～80g, fruit of glossy privet 45g～55g, blackberry lily 30g～40g, coix seed 25g～35g, stem of noble dendrobium 30g～40g,Coptis 55g～65g, cordate houttuynia 25g～35g, wind-weed 30g～40g, madder 30g～40g, caulis bambusae in taenian 25g～35g, hairyvein agrimony 35g～45g, Radix Angelicae Sinensis 20g～30g, radix paeoniae rubrathe 30g～40g, chrysanthemum 35g～45g, cowherbArt 25g～35g, Selaginella tamariscina 30g～40g, radix pseudostellariae 35g～45g, yncaria stem with hooks 30g～40g, Chinese yam 20g～30g, mountain wax plum 25g～35g, wooden blue 25g～35g, meadow fescue 30g～40g, eleusine indica 25g～35g,White wine grass 30g～40g, Samson St Johswort 15g～25g, franzenbach rhubarb root and rhizome 20g～30g, date 20g～30g, TuSilk 30g～40g, aleppo avens 40g～50g, sealwort 30g～40g, radix ranunculi ternati 25g～35g, mulberry are postedRaw 20g～30g, Japanese cryptotaenia stem and leaf 25g～35g and caulis lonicerae 15g～25g.

Further preferably, in described Chinese medicine preparation, the weight of each component is respectively wilsonii 60g～65g, partyGinseng 75g～80g, fruit of glossy privet 50g～55g, blackberry lily 35g～40g, coix seed 30g～35g, stem of noble dendrobium 35g～40g, coptis 60g～65g, cordate houttuynia 30g～35g, wind-weed 35g～40g, madder 35g～40g, bambooEat 30g～35g, hairyvein agrimony 40g～45g, Radix Angelicae Sinensis 20g～25g, radix paeoniae rubrathe 30g～35g, chrysanthemum 35g～40g, curcuma zedoary 25g～30g, Selaginella tamariscina 30g～35g, radix pseudostellariae 35g～40g, yncaria stem with hooks 30g～35g, mountainMedicine 20g～25g, mountain wax plum 25g～30g, wooden blue 25g～30g, meadow fescue 30g～35g, eleusine indica25g～30g, white wine grass 30g～35g, Samson St Johswort 15g～20g, franzenbach rhubarb root and rhizome 20g～25g, date 20g～25g, seed of Chinese dodder 30g～35g, aleppo avens 40g～45g, sealwort 30g～35g, radix ranunculi ternati 30g～35g,Parasitic loranthus 20g～25g, Japanese cryptotaenia stem and leaf 30g～35g and caulis lonicerae 20g～25g.

Most preferably, in described Chinese medicine preparation, the weight of each component is respectively wilsonii 60g, Radix Codonopsis 75g, femaleLoyal sub-50g, blackberry lily 35g, coix seed 30g, stem of noble dendrobium 35g, coptis 60g, cordate houttuynia 30g, the wind-weed35g, madder 35g, caulis bambusae in taenian 30g, hairyvein agrimony 40g, Radix Angelicae Sinensis 25g, radix paeoniae rubrathe 35g, chrysanthemum 40g, cowherbArt 30g, Selaginella tamariscina 35g, radix pseudostellariae 40g, yncaria stem with hooks 35g, Chinese yam 25g, mountain wax plum 30g, wooden blue 30g,Meadow fescue 35g, eleusine indica 30g, white wine grass 35g, Samson St Johswort 20g, franzenbach rhubarb root and rhizome 25g, date 25g,Seed of Chinese dodder 35g, aleppo avens 45g, sealwort 35g, radix ranunculi ternati 30g, parasitic loranthus 25g, Japanese cryptotaenia stem and leaf 30gWith caulis lonicerae 20g.

The pharmacology of each bulk drug is as follows:

Wilsonii: be root, rhizome or the cauline leaf of studies on plants of Acanthopanax Miq. in Araliaceae wilsonii, latin nameAcanthopanacisSenticosiRadixetRhizomaseuCaulis, taste is pungent, bitter, micro-sweet, warm in nature,Enter spleen, kidney, the heart channel of Hang-Shaoyin, have and replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, the effect of dispelling rheumatism, wet for chillNumbness, lumbocrural pain, muscles and bones impotence is soft, be slow in action, body void is thin and weak, traumatic injury, fracture, oedema,Beriberi, the uncontrolled urination card such as itch.

Radix Codonopsis: taste is sweet, property is flat, returns lung, the spleen channel, has tonifying Qi benefit spleen, and effect of nourishing blood to promote the production of body fluid is mainControl spleen-lung Qi deficiency or qi-blood deficiency lassitude hypodynamia, breathe hard, the symptoms such as cough spontaneous perspiration, Radix Codonopsis is longer than tonifying spleenNourishing the stomach, adjusts regulating the function of middle-JIAO, has the effect of nourishing blood concurrently, and its property is flat, invigorating the spleen fortune and not dry; Flavour is cloudy and not wet,Can improve the immune state of body, improve resistance against diseases, promote to digest and assimilate, improve metabolism,Promote the absorption of enteron aisle to nutriment.

The fruit of glossy privet: taste is sweet, bitter, is slightly cold, enters liver, kidney channel, has strong liver kidney-nourishing, the effect of removing heat to brighten vision,Be mainly used in treating liver-kidney Yin deficiency, the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat. Fruit of glossy privet energyPromote leucocyte, strengthen effect of immunologic function, have stronger to staphylococcus aureus, shigella dysenteriaeInhibitory action. Modern medicine study proves, the fruit of glossy privet include ursolic acid, sweet mellow wine, glucose,Fat wet goods, has cardiac stimulant, diuresis and hepatoprotective effect, can make the leucocyte decline number causing because of chemotherapyAmount raises, and staphylococcus aureus, Escherichia coli are had to inhibitory action.

Blackberry lily: bitter, cold in nature, return lung, Liver Channel, have clearing heat and detoxicatingly, the effect of clear phlegm relieve sore throat, usesIn the malicious convulsive seizure due to phlegm-fire pent-up of heat, abscess of throat, accumulation and obstruction of sputum, the cards such as cough and asthma.

Coix seed: taste is sweet, property is light, returns spleen, stomach, lung channel, has invigorating the spleen excreting dampness, clearing away heat and eliminating pus, removesEffect of numbness, Li Shui, cures mainly difficult urination, oedema, beriberi, lung carbuncle, acute appendicitis, arthralgia due to wind-dampness, muscleThe cards such as arteries and veins contraction urgency and damp-warm diseases.

The stem of noble dendrobium: cold nature, taste is sweet, enters stomach, kidney channel, has reinforcing stomach reg fluid, nourishing Yin and clearing heat effect,For heat consuming body fluid, low-heat polydipsia, the red few tongue of tongue, deficiency of stomach-Yin, thirsty and dry pharynx, the contrary few food of vomitting, stomachGastral cavity secret anguish, the few tongue of tongue light, the deficiency of the kidney yin, the cards such as blurring of vision.

The coptis: bitter, cold in nature, the thoughts of returning home, lung, courage, stomach, large intestine channel, have heat-clearing and damp-drying drug, purging intense heatEffect of removing toxic substances, cooling blood for improving eyesight, is longer than the fire of removing the heart-fire warp, cures mainly the dysphoria and insomnia of internal heat due to prosperous, andThe high fever coma of warm heat disease, vexed, thirsty; Also can be used for dysentery due to damp and hot, tenesmus; HeatThe cards such as carbuncle carbuncle, eczema, aphthae, epidemic conjunctivitis.

Cordate houttuynia: latin name houttuyniaeherba, taste is pungent, and cold nature enters lung, urinary bladder channel, toolHave clearing heat and detoxicating, removing pus and relieving carbuncle, effect of inducing diuresis for treating strangurtia, for lung carbuncle pyemesis, phlegm heat is coughed and is breathed heavily, heat poisonBloody flux, damp-heat gonorrhoea, hot carbuncle carbuncle, snakeworm is wanted first-class card.

The wind-weed: bitter, sweet, cold in nature, enter lung, stomach, kidney channel, there is the relieving restlessness of purging heat, nourshing Yin and drynsessmoistening prescription, clearThe effect of lung cough-relieving, cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior heat symptom such as quench one's thirst; ItsBitter cold matter profit, property sedimentation, can heat-clearing, can promote the production of body fluid again, kindly controls warm disease and evil and enters gas and divide, and heat is contained and is hindered Tianjin;Also be used for the treatment of diabetes; Phlegm-heat obstructing lung and breathing heavily, xeropulmonary cough, phlegm is few unfavorable; Fire excess from yin deficiency, the fire of deficiency typeThe symptoms such as upper inflammation.

Madder: cold in nature, bitter, the effect of there is cooling blood and hemostasis, the stasis of blood of dispelling being stimulated the menstrual flow, absurd for blood-headThe haemorrhage of row, the extravasated blood person that holds concurrently are especially suitable, for stasis of blood stagnate-closed warp, postpartum stasis blocking stomachache, treating swelling and pain by traumatic injury,The cards such as arthralgia due to wind-dampness.

Caulis bambusae in taenian: cold nature, taste is sweet, attaches to the lung and stomach meridians, and has clearing heat and eliminating phlegm, the effect relieving restlessness and preventing vomiting,Hold phlegm, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, apoplexy phlegm fan, aphasia with stiff tongue, stomach under the arm for phlegm-heat cough, courage fireThe cards such as hot vomiting, pernicious vomiting, fetal irritability.

Hairyvein agrimony: latin name AgrimoniaeHerba, bitter, puckery, property is flat, the thoughts of returning home, Liver Channel,Have astringing to arrest bleeding, only effect of dysentery desinsection, cures mainly various hemorrhage cards, for example: spit blood, urinateBlood, have blood in stool, uterine bleeding, spitting of blood, bleeding from five sense organs or subcutaneous tissue, dysentery, internal lesion caused by overexertion takes off power, carbuncle is swollen, falls and beats, woundHinder the hemorrhage card of Denging.

Radix Angelicae Sinensis: latin name angelicaesinensisradix, taste is sweet, pungent, bitter, warm in nature, return liver, the heart,The spleen channel, having enriches blood invigorates blood circulation, and menstruation regulating relieves the pain, and the effect relaxing bowel cures mainly head's dusk of deficiency of heart-bloodDizzy, lassitude hypodynamia, palpitation, and other syndrome of blood deficiency. Sea of blood inanition, the cold and deficiency of chong and ren channels or extravasated blood retardanceIrregular menstruation, the amount cards such as phase that spread out less.

The radix paeoniae rubrathe: bitter, micro-hardship, return Liver Channel, there is purge the green, clearing heat and cooling blood, effect of stasis-dispelling and pain-killing,Cure mainly the red eye, swell pain that irascibility is vigorous, have a dizzy spell, pain in chest and hypochondrium, the hot tongue of body of warm heat disease heat invading xuefenDeep red, macula is hemorrhage, and blood stasis is through closing; The haematemesis hematuria of the burning hot absurd row of flourishing urgent blood; Women's blood-head itPass through too much; The caused various pain of blood retardance; The swollen card that waits of sore furuncle carbuncle of blood-head poison Sheng.

Chrysanthemum: latin name ChrysanthemiFlos, taste is pungent, sweet, bitter, and cold nature is returned lung, Liver Channel,There is effect of dispelling wind clearing liver, flat liver improving eyesight, removing toxicity for detumescence, cure mainly affection of exogenous wind-heat and warm disease from the beginning of, headDizzy dizzy, blurring of vision, red eye, swell pain, the swollen card that waits of hot malicious carbuncle.

Curcuma zedoary: taste is pungent, bitter, warm in nature, enters liver, the spleen channel, has broken blood gas, effect of the long-pending pain relieving that disappears,For the abdominal mass lump in the abdomen of caused by energy stagnation and blood stasis, chest abdomen stasis of blood pain, amenorrhoea, dysmenorrhoea, abdominal distention, falls to beat and damagesWound, the blood stasis card such as swell and ache.

Selaginella tamariscina: latin name SelaginellaeHerba is being dried of Spikemoss plant Selaginella tamariscina or cushion Selaginella tamariscinaHerb: taste is pungent, and property is flat, returns liver, the heart channel of Hang-Shaoyin, has effect of activating blood to promote menstruation. Be used for through closing painWarp. Wei lump in the abdomen lump in the abdomen, injury from falling down, spits blood, and uterine bleeding, has blood in stool, the cards such as prolapse of the anus.

Radix pseudostellariae: sweet, the micro-hardship of taste, property is flat, returns spleen, lung channel, has air making-up and spleen enlivening, moistening lung is promoted the production of body fluidEffect, cures mainly the poor appetite due to deficiency-weakness of spleen-QI, lassitude hypodynamia, and deficiency syndrome of the lung cough caused by dryness, syndrome characterized by dyspnea is breathed hard, temperaturePhase after being ill, hinder in gas Tianjin two, the thirsty card that waits of interior heat.

Yncaria stem with hooks: taste is sweet, slightly warm in nature, enters Liver Channel, has the effect of heat-clearing, calming the liver, relieving convulsion and spasm,Be mainly used in the spasm due to the anxious raw wind of heat or liver wind agitation, twitch, restlessness, liver-yang hyperactivity or liverThrough there being the headache of heat dizzy, the symptoms such as red eye, swell pain.

Chinese yam: latin name dioscoreaerhizoma, taste is sweet, and property is flat, enters lung, spleen, kidney channel, hasStrengthening the spleen and tonifying the lung, beneficial stomach kidney tonifying, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, strengthening the bones and muscles, grow will calm the nerves,The effect of promoting longevity, cures mainly weakness of the spleen and the stomach, lassitude, poor appetite, chronic diarrhea and dysentery, Lung Qi deficiencyDry, asthma due to excessive phlegm cough, kidney qi loss, soreness and weakness of waist and knees, lower limb impotence are weak, the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, bandThe red card such as swollen, fat of lower gonorrhoea, skin.

Mountain wax plum: be the leaf of Calycanthaceae wax plum platymiscium mountain wax plum, pungent, the micro-hardship of taste, warm in nature, have and dispelWind, relieving exterior syndrome, removes dampness by means of aromatics, and cures mainly influenza, heatstroke, and chronic bronchitis, wet tired uncomfortable in chest, mosquito ant fourth is stungDeng card.

Wood is blue: be the blue cauline leaf of pulse family anil wood, mildly bitter flavor, cold in nature, have clearing heat and detoxicating,Effect of cooling blood and hemostasis, cures mainly encephalitis B, mumps, and acute laryngopharyngitis, lymphnoditis, hot eyes,Aphtha, erysipelas, worm snake bite, the cards such as haematemesis.

NIUWEISHEN: taste is pungent, warm in nature, there is strengthening the spleen and replenishing qi, the effect of invigorating the lung and the kidney, cures mainly insufficiency of the spleen food few,Have loose bowels, emission due to the kidney deficiency, quenches one's thirst, lung impairment and cough, the cards such as traumatic injury.

Eleusine indica: taste is sweet, light, cool in nature, have clearing heat and detoxicating, dampness removing, effect of cool the blood dissipate blood stasis, mainThe heat that cures the wound heating, child convulsion, encephalitis, epidemic meningitis, jaundice, stranguria, difficult urination, dysentery, has blood in stool,The cards such as traumatic injury.

White wine grass: bitter, pungent, cold in nature, there is clearing away heat to and alleviating pain, effect of dispelling pathogenic wind and eliminating phlegm, cures mainly laryngitis,Pneumonia, abscess of throat, the cards such as tonsillitis.

Franzenbach rhubarb root and rhizome: latin name RadixetRhizomeRheiFranzenbachii is polygonaceae plant ripple leafThe root and rhizome of rheum officinale, bitter; Cold in nature, return stomach; Large intestine channel, has the removing toxic substances of purging heat; Cool bloodEffect of the stasis of blood, cures mainly jaundice with damp-heat pathogen; Dysentery; Through closing stomachache; Hematemesis and epistaxis; Fall and beat stasis of blood pain; CarbuncleSwollen serious case of furuncle; The erosion of mucous membrane in the oral cavity; The cards such as burn and scald.

Samson St Johswort: be the herb of Guttiferae hypericum Samson St Johswort, bitter, pungent, cold in nature, return liver,The spleen channel, has removing pattogenic heat from the blood and toxic material from the body, promoting blood circulation for regulating menstruation, effect of dispelling wind and removing obstruction in the meridians, cure mainly various hemorrhage, enteritis dysenteryDisease, acute mastitis, the carbuncle serious case of furuncle that swells, scalds, snake bite, irregular menstruation, dysmenorrhoea, leukorrhea, traumatic injury,Arthralgia due to wind-dampness, the cards such as aphtha.

Date: latin name jujubaefructus, taste is sweet, warm in nature, returns spleen, stomach warp, has tonifying spleen and stomach,Nourishing generate fluid, adjusts battalion to defend, and effect of antidote poison cures mainly the empty food of stomach few, the weak loose stool of spleen, and qi-blood-body fluid is notFoot, disharmony between ying and wei, palpitation and severe palpitation, the hot-tempered card that waits of married woman's stolen goods.

The seed of Chinese dodder: taste is sweet, pungent, property is flat, enters liver,kidney,spleen warp, has tonifying kidney and benefiting sperm, nourishes the liver to improve visual acuityAct on, be mainly used in the impotence of the insufficiency of the kidney yang, seminal emission premature ejaculation, frequent urination, dizziness and tinnitus; The waist of suffering from a deficiency of the kidneyPain, married woman is with down, and nausea is not solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; SpleenThe loose stool stomachache of kidney two void, the cards such as diarrhea with undigested food.

Aleppo avens: latin name GeiHerba, taste is pungent, bitter, and property is flat, returns liver, spleen, lung channel, hasAnalgesia, step-down, menstruation regulating, the effect of dispelling rheumatism, cures mainly high blood pressure, dizziness headache, menstruationUncomfortable, the pain of lower abdomen, leukorrhea, child convulsion, lumbago, skelalgia of rheumatism; Carbuncle furuncle poison is controlled in external application, falls and beatsThe cards such as damage.

Sealwort: taste is sweet, property is flat, enters lung, spleen, kidney channel, has the yin-nourishing of fostering the spirit of nobility, invigorating the spleen moistening lung,Effect of enriching kidney essence, for taste deficiency of qi and yin, food is few unable, the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough,Quenching one's thirst of yin asthenia generating intrinsic heat, the cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Radix ranunculi ternati: latin name RanunculiTernatiRadix, taste is sweet, pungent, warm in nature, returns liver, lung channel,There is effect of blood stasis-eliminating and stagnation-dissipating, removing toxicity for detumescence, cure mainly scrofula subcutaneous nodule, furunculosis, worm snake bite, antimigraine,Malaria, toothache. Pulmonary tuberculosis, scrofula, lymphnoditis, the cards such as sphagitis.

Parasitic loranthus: bitter, sweet, property is flat, enters liver, kidney channel, have filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic,The effect of antiabortive unit, for the soreness of waist pain due to kidney deficiency and liver, muscles and bones impotence is soft, the foot and knee being feeble, liver kidneyDeficiency, essence and blood is empty to be lost, the fetal irritability of liability to be abortion, the cards such as waist abdomen pain.

Japanese cryptotaenia stem and leaf: taste is pungent, hardship; Property is put down, and has dispelling wind stopping cough; Eliminating damp, detoxifying; Effect of blood-activating analgetic,Cure mainly pneumonia, pulmonary abscess, gonorrhoea, hernia, acute toothache, ulcer malignant boil is swollen, herpes zoster, skin scabiesThe card such as itch.

Caulis lonicerae: taste is sweet, cold in nature, attach to the lung and stomach meridians, have clearing heat and detoxicating, effect of dispelling wind dredging collateral,Cure mainly warm disease heating, toxic-heat and blood stasis, the carbuncle sore that swell, rheumatic fever numbness, card such as redness and swelling of joints heat pain grade.

Chinese medicine preparation provided by the invention can be prepared into capsule and oral liquid.

It is above-mentioned for preventing the Traditional Chinese medicine preparation capsule of nasopharyngeal carcinoma radiation side reaction that the present invention also providesThe preparation method of agent, is specially:

The first step, by blackberry lily, the coptis, cordate houttuynia, the wind-weed, caulis bambusae in taenian, hairyvein agrimony, chrysanthemum, mountain wax plum,Wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, radix ranunculi ternati, Japanese cryptotaenia stem and leaf and caulis lonicerae powder respectivelyBroken, mix in proportion, obtain mixture, add the water doubly with respect to mixture quality 7-9, soak 3-5After hour, distill 3-5 hour, collect volatile oil, the dregs of a decoction are for subsequent use;

Second step, pulverizes remaining component respectively, puts into continuous extraction and fills with, then add the first step to obtainThe dregs of a decoction, adding determining alcohol is the alcohol extract 3-5 hour of 70%-80%, described in the amount of alcohol adding isDoubly, extract filters the 3-5 of the each bulk drug quality of Chinese medicine preparation sum, and filtrate is concentrated into relative density and isThe lotion of 1.25～1.30 (65 DEG C), lets cool;

The 3rd step, gets the above-mentioned lotion of 500g, adds the excipient starch of 1kg-2kg to be mixed into softwood, mistakeSieve series grain and in 55-65 DEG C dry, after whole grain, obtain particle, then the volatile oil that adds the first step to obtain,Encapsulated.

It is above-mentioned for preventing the Chinese medicine preparation of nasopharyngeal carcinoma radiation side reaction oral that the present invention also providesThe preparation method of liquid, is specially:

The first step, by blackberry lily, the coptis, cordate houttuynia, the wind-weed, caulis bambusae in taenian, hairyvein agrimony, chrysanthemum, mountain wax plum,Wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, radix ranunculi ternati, Japanese cryptotaenia stem and leaf and caulis lonicerae powder respectivelyBroken, mix in proportion, obtain mixture, add the water doubly with respect to mixture quality 7-9, soak 3-5After hour, distill 3-5 hour, collect volatile oil, the dregs of a decoction are for subsequent use;

Second step, pulverizes remaining component respectively, puts into continuous extraction and fills with, then add the first step to obtainThe dregs of a decoction, extracting in water 3-5 hour, the water yield adding be the each bulk drug quality of described Chinese medicine preparation itWith 6-8 doubly, extract filters, and is concentrated into relative density 1.10-1.12 (60 DEG C), static 24 hours,Get supernatant and reclaim ethanol and be concentrated into relative density 1.04 (20 DEG C), leave standstill 48 hours, get supernatant filterCross, volatile oil, Tween-80 and appropriate flavouring that filtrate adds the first step to prepare, adjust volume extremely1000ml, filters, packing, and sterilizing, obtains described oral liquid.

Below adopt embodiment to describe embodiments of the present invention in detail, whereby how the present invention is appliedTechnological means solves technical problem, and the implementation procedure of reaching technique effect can fully understand and real according to thisExecute.

Embodiment 1 oral liquid 1

By blackberry lily 35g, coptis 60g, cordate houttuynia 30g, wind-weed 35g, caulis bambusae in taenian 30g, hairyvein agrimony 40g,Chrysanthemum 40g, mountain wax plum 30g, wooden blue 30g, meadow fescue 35g, eleusine indica 30g, white wine grass 35g, unitPrecious careless 20g, radix ranunculi ternati 30g, Japanese cryptotaenia stem and leaf 30g and caulis lonicerae 20g pulverize respectively, mix, and obtain and mixThing, adds the water of 3.8kg, soaks and distills 5 hours after 5 hours, collects volatile oil, and the dregs of a decoction are for subsequent use,By wilsonii 60g, Radix Codonopsis 75g, fruit of glossy privet 50g, coix seed 30g, stem of noble dendrobium 35g, madder 35g, whenReturn 25g, radix paeoniae rubrathe 35g, curcuma zedoary 30g, Selaginella tamariscina 35g, radix pseudostellariae 40g, yncaria stem with hooks 35g, Chinese yam 25g,Franzenbach rhubarb root and rhizome 25g, date 25g, seed of Chinese dodder 35g, aleppo avens 45g, sealwort 35g, parasitic loranthus 25g divideNot Fen Sui, put into continuous extraction and fill with, then add the dregs of a decoction that obtain above, add 4kg water extraction and get 5 hours,Extract filters, and is concentrated into relative density 1.10 (60 DEG C), static 24 hours, gets supernatant and reclaims ethanolAnd be concentrated into relative density 1.04 (20 DEG C), and leave standstill 48 hours, get supernatant and filter, before filtrate addsThe volatile oil, Tween-80 and the appropriate flavouring that obtain, adjust volume to 1000ml, filter, and packing,Sterilizing, obtains described oral liquid 1.

Embodiment 2 oral liquids 2

By blackberry lily 40g, coptis 65g, cordate houttuynia 35g, wind-weed 40g, caulis bambusae in taenian 35g, hairyvein agrimony 45g,Chrysanthemum 40g, mountain wax plum 30g, wooden blue 30g, meadow fescue 35g, eleusine indica 30g, white wine grass 35g, unitPrecious careless 20g, radix ranunculi ternati 35g, Japanese cryptotaenia stem and leaf 35g and caulis lonicerae 25g pulverize respectively, mix, and obtain and mixThing, adds the water of 4kg, soaks and distills 5 hours after 5 hours, collects volatile oil, and the dregs of a decoction are for subsequent use, willWilsonii 65g, Radix Codonopsis 80g, fruit of glossy privet 55g, coix seed 35g, stem of noble dendrobium 40g, madder 40g, Radix Angelicae Sinensis25g, radix paeoniae rubrathe 35g, curcuma zedoary 30g, Selaginella tamariscina 35g, radix pseudostellariae 40g, yncaria stem with hooks 35g, Chinese yam 25g, mountainRheum officinale 25g, date 25g, seed of Chinese dodder 35g, aleppo avens 45g, sealwort 35g, parasitic loranthus 25g are respectivelyPulverize, put into continuous extraction and fill with, then add the dregs of a decoction that obtain above, add 4kg water extraction and get 5 hours,Extract filters, and is concentrated into relative density 1.10 (60 DEG C), static 24 hours, gets supernatant and reclaims ethanolAnd be concentrated into relative density 1.04 (20 DEG C), and leave standstill 48 hours, get supernatant and filter, before filtrate addsThe volatile oil, Tween-80 and the appropriate flavouring that obtain, adjust volume to 1000ml, filter, and packing,Sterilizing, obtains described oral liquid 2.

Embodiment 3 oral liquids 3

By blackberry lily 35g, coptis 60g, cordate houttuynia 30g, wind-weed 35g, caulis bambusae in taenian 30g, hairyvein agrimony 40g,Chrysanthemum 35g, mountain wax plum 25g, wooden blue 25g, meadow fescue 30g, eleusine indica 25g, white wine grass 30g, unitPrecious careless 15g, radix ranunculi ternati 30g, Japanese cryptotaenia stem and leaf 30g and caulis lonicerae 20g pulverize respectively, mix, and obtain and mixThing, adds the water of 3.8kg, soaks and distills 5 hours after 5 hours, collects volatile oil, and the dregs of a decoction are for subsequent use,By wilsonii 60g, Radix Codonopsis 75g, fruit of glossy privet 50g, coix seed 30g, stem of noble dendrobium 35g, madder 35g, whenReturn 20g, radix paeoniae rubrathe 30g, curcuma zedoary 25g, Selaginella tamariscina 30g, radix pseudostellariae 35g, yncaria stem with hooks 30g, Chinese yam 20g,Franzenbach rhubarb root and rhizome 20g, date 20g, seed of Chinese dodder 30g, aleppo avens 40g, sealwort 30g, parasitic loranthus 20g divideNot Fen Sui, put into continuous extraction and fill with, then add the dregs of a decoction that obtain above, add 4kg water extraction and get 5 hours,Extract filters, and is concentrated into relative density 1.10 (60 DEG C), static 24 hours, gets supernatant and reclaims ethanolAnd be concentrated into relative density 1.04 (20 DEG C), and leave standstill 48 hours, get supernatant and filter, before filtrate addsThe volatile oil, Tween-80 and the appropriate flavouring that obtain, adjust volume to 1000ml, filter, and packing,Sterilizing, obtains described oral liquid 3.

Embodiment 4 capsules

By blackberry lily 35g, coptis 60g, cordate houttuynia 30g, wind-weed 35g, caulis bambusae in taenian 30g, hairyvein agrimony 40g,Chrysanthemum 40g, mountain wax plum 30g, wooden blue 30g, meadow fescue 35g, eleusine indica 30g, white wine grass 35g, unitPrecious careless 20g, radix ranunculi ternati 30g, Japanese cryptotaenia stem and leaf 30g and caulis lonicerae 20g pulverize respectively, mix, and obtain and mixThing, adds the water of 3.8kg, soaks and distills 5 hours after 5 hours, collects volatile oil, and the dregs of a decoction are for subsequent use,By wilsonii 60g, Radix Codonopsis 75g, fruit of glossy privet 50g, coix seed 30g, stem of noble dendrobium 35g, madder 35g, whenReturn 25g, radix paeoniae rubrathe 35g, curcuma zedoary 30g, Selaginella tamariscina 35g, radix pseudostellariae 40g, yncaria stem with hooks 35g, Chinese yam 25g,Franzenbach rhubarb root and rhizome 25g, date 25g, seed of Chinese dodder 35g, aleppo avens 45g, sealwort 35g, parasitic loranthus 25g divideNot Fen Sui, put into continuous extraction and fill with, then add the dregs of a decoction that obtain above, adding 2.5kg determining alcohol is 80%Alcohol extract 5 hours, extract filters, filtrate is concentrated into the lotion that relative density is 1.30 (65 DEG C),Let cool, get the above-mentioned lotion of 500g, add the excipient starch of 1kg to be mixed into softwood, sieve granulate and in55 DEG C dry, obtains particle, then add the volatile oil obtaining above after whole grain, encapsulated.

Toxicological experiment

Acute toxicity test:

Choose 20 of NIH kind mouse, male and female half and half, body weight is 20.61 ± 1.37g, pressThe dosage gastric infusion of 40ml/kg, one day twice, observe seven, without anomaly, without dead, bodyHeavily increase to 26.32 ± 1.93g, compared with increasing weight 27.70% before administration.

The oral liquid clinical medicine dose of Chinese medicine preparation of the present invention is 10ml × 2=20ml every day, becomes human bodyHeavily, by 60kg, adult's oral dose is 20ml/60kg=0.334ml/kg, mouse dosage every dayBe 40 × 2=80ml/kg, quite the 80/0.334=240 of people's consumption doubly.

The oral liquid formulations of Chinese medicine preparation of the present invention is oral ampulla, selects 10 of NIH kind mouse, withThe dosage tail vein injection that 0.5mL is every, 8-10 at the uniform velocity injects second, observes 72 hours, without anomaly,Without dead.

Result of the test shows: the oral liquid toxicity of Chinese medicine preparation of the present invention is less.

Long term toxicity test:

60 of the Wistar rats of experimental animal: 7-8 health in age in week, male and female half and half. Before test, observe oneIn week, adopt randomized blocks that rat is divided into three groups, and 20 every group, male and female half and half, sub-cage rearing. FixedPhase is recorded rats eating amount, freely drinks water. Claim weekly body weight one time.

Oral liquid 1 prepared by tested material and dosage: embodiment 1

Dosage group is by the requirement of acute toxicity testing result and new Chinese medicine toxicologic study guide, establishes heightLow two dosage groups and a control group. High dose is 1200g/kg, is equivalent to 70 of clinical application amountDoubly, low dose group is 500g/kg, is equivalent to 30 times of clinical application amount. Method of administration and method: adoptIntragastrically. Every day 1 time, 6 days weekly, amount to 8 weeks. During administration, press changes of weight adjustment weeklyDosage.

Observation index:

Ordinary circumstance: observe outward appearance sign every day, behavioral activity, urine excrement situation, food-intake. Claim weeklyBody weight is observed and is changed.

Hematological examination: get at random 10 rats (male and female half and half) for every group, before administration, after administration the 4thWeek and the 8th week, at tail venous blood sampling, red blood cell, classification for leucocyte, blood platelet, net are knitted red thinThe index such as born of the same parents and content of hemoglobin is tested by " national clinical examination operational procedure " requirement.

Rat is dissected and histopathologic examination: experiment finishes, and gets 10 rats (male and female half and half) for every group,Thigh portion blood vessel sacrificed by exsanguination, conventional dissection, observes the mode of appearance of each internal organs, color etc., and to the heart,The internal organs such as liver, spleen, lung, kidney, brain are weighed, and calculate the percentage of itself and body weight, i.e. organ coefficient. SoAfter pathology method processing routinely, do the Histopathology of the heart, liver, spleen, lung, kidney, brain and femurCheck.

Result:

General state and changes of weight: during administration, each treated animal general state, movable normal, have noAbnormal response. Administration group and control group food-intake are substantially close. Administration group and control group body weight gain trendBasically identical, illustrate that long term administration has no significant effect growth of animal. Male mouse or the each administration group of female mouse body weightIncreasing value compared with control group, no significant difference (P > 0.05).

Hematological indices: height, end dosage group red blood cell, platelet, blood platelet and hemoglobinContent before administration, after administration 4 weeks and 8 weeks, compared with control group, P > 0.05, illustrates medicine pairAbove-mentioned each index has no significant effect.

Histopathologic examination: off-test, rat is dissected, do not find the heart, liver, spleen, lung, kidney,The obvious change of the organs such as brain. Histopathologic examination does not find that there is pathological change yet, show for a long time toMedicine to each organs and tissues without obvious damage.

Brief summary:

Within continuous 8 weeks, pour into oral liquid 1 prepared by embodiment 1 to rat oral, dosage is quantity70 times and 30 times, rat general state is good, without Novel presentation, respectively organizes bodyweight difference without conspicuousness,Rat normal growth is had no significant effect.

Administration in continuous 8 weeks, blood index is not remarkable, and oral liquid 1 length prepared by embodiment 1 is describedPhase toxicity test result shows, finds no pathological change.

Above result of the test shows, oral liquid 1 provided by the invention uses for a long time, without overt toxicity, isSafer Chinese medicine preparation.

Clinical data

Physical data

In January, 2006～2012 year October, amount to the Nasopharyngeal Carcinoma Patients that 285 routine initial journeies receive treatment and enterGroup, and prediction is divided into test group and control group at random. Wherein male 178 examples, female's 107 examples, the age from17 years old～72 years old; Before all patient's radiotherapies, all confirm through pathology, and all have CT/MRI inspectionLook into for clinical stages, before chemotherapy, all do before chemotherapy and check and confirm without chemicotherapy contraindication by clinical criteria, willAll patients are divided into two groups, treatment group 145 examples, male 90 examples, female's 55 examples, control group 140 examples, man88 examples, female's 52 examples, two groups of clinical datas have comparativity.

Method

Radiation therapy method

All patients is all accepted radiotherapy, radioactive source be linear accelerator 6～8MV photon line and8～12Mev electron ray, adopts the method for conventional fractionated irradiation, each 2Gy, and every day 1 time,5 times weekly, center, nasopharynx target area dosage 68～72Gy; Neck radical cure dosage 60～66Gy, preventionDosage 50～52Gy.

Embolic chemotherapy

All patients all adopts cis-platinum (DDP) to carry out the chemotherapy same period. DDP dosage and usage: 30mg/m²，Add 3% sodium chloride solution 500ml drip-feed, from radiotherapy the 1st week, 1 time weekly,Totally 6 times.

Medication

Treatment group is taken oral liquid 1 prepared by the embodiment of the present invention 1, and every day, 20ml, took at twice,Start to finish to radiotherapy from radiotherapy.

Observation index and method

(1) in treatment, check weekly whole blood routine 1 time. Every 2 weekly check 1 liver, renal function and the heartElectrograph. (2) toxicity that observation caliber: RTOG (radiation oncology treatment cooperative groups), WHO formulateGrade scale. Mucosa reaction: 0 grade, normal; I level, erythema, has mild pain, does not need anodyne;II level, mottled mucositis, companion's serosity is oozed out, medium degree pain; III level, slabbing cellulose is glutinousFilm inflammation, sharp ache, needs anodyne; IV level, hemorrhage, ulcer, necrosis.

Statistical method

Adopt SPSS10.0 statistical software, enumeration data rate relatively use χ²Inspection, ranked data are usedNon-parametric test rank test.

Result

Two groups of acute reaction comparisons, the results are shown in Table 1.

Two groups of acute reactions (n)

As can be seen from Table 1, treatment group is obviously better than control group to alleviating of mucous membrane of mouth and gastrointestinal reaction,Statistically there is significant difference, P < 0.05.

Two groups of hematological index comparisons, the results are shown in Table 2.

Table 2 liang group hematological system toxicity

As can be seen from Table 2, in the reaction of experimental group hematological system, WBC, RBC, Hb decline and contrastGroup obviously alleviates, and statistically has a significant difference, P < 0.05.

Before and after two groups of treatments, the comparison of hepatic and renal function, the results are shown in Table 3.

Before and after the treatment of table 3 hepatic and renal function, compare

Group		ALT(U/L)	GGT(U/L)	UN(mmol/L)	CR(μmol/L)
						Experimental group	Before chemicotherapy	28.34±13.38	37.13±29.27	5.24±1.37	107.33±13.86
	After chemicotherapy	22.56±12.94	30.15±25.23	4.01±1.21	100.97±15.04
						Control group	Before chemicotherapy	29.12±14.13	36.12±22.31	5.24±2.01	105.11±14.23
	After chemicotherapy	24.41±13.15	34.35±19.18	41.86±1.89	103.05±20.07

As seen from Table 3: after experimental group chemicotherapy, ALT, UN, CR value significantly reduce, tool statisticsMeaning (P < 0.05); And control group A LT, UN, CR value compared with chemicotherapy before without marked change (P >0.05)。

In chemicotherapy process, because toxicity interrupts number of days, the results are shown in Table 4.

In table 4 chemicotherapy process because of toxicity interrupt number of days n (%)

All above-mentioned these intellectual properties of primary enforcement, do not set the other forms of enforcement of restriction thisPlant new product and/or new method. Those skilled in the art will utilize this important information, foregoing amendment,To realize similar implementation status. But all modifications or transformation belong to reservation based on new product of the present inventionRight.

The above, be only preferred embodiment of the present invention, is not that the present invention is made to other formRestriction, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changedOr be modified as the equivalent embodiment of equivalent variations. But every technical solution of the present invention content that do not depart from, complies withAny simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention,Still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. for preventing a Chinese medicine preparation for nasopharyngeal carcinoma radiation side reaction, it is characterized in that: formerMaterial medicine by wilsonii, Radix Codonopsis, the fruit of glossy privet, blackberry lily, coix seed, the stem of noble dendrobium, the coptis, cordate houttuynia, the wind-weed,Madder, caulis bambusae in taenian, hairyvein agrimony, Radix Angelicae Sinensis, the radix paeoniae rubrathe, chrysanthemum, curcuma zedoary, Selaginella tamariscina, radix pseudostellariae, yncaria stem with hooks, mountainMedicine, mountain wax plum, wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, franzenbach rhubarb root and rhizome, date, TuSilk, aleppo avens, sealwort, radix ranunculi ternati, parasitic loranthus, Japanese cryptotaenia stem and leaf and caulis lonicerae form;

The weight of each bulk drug be respectively wilsonii 55g～65g, Radix Codonopsis 70g～80g, fruit of glossy privet 45g～55g, blackberry lily 30g～40g, coix seed 25g～35g, stem of noble dendrobium 30g～40g, coptis 55g～65g, fishRaw meat grass 25g～35g, wind-weed 30g～40g, madder 30g～40g, caulis bambusae in taenian 25g～35g, hairyvein agrimony 35g～45g, Radix Angelicae Sinensis 20g～30g, radix paeoniae rubrathe 30g～40g, chrysanthemum 35g～45g, curcuma zedoary 25g～35g, Selaginella tamariscina30g～40g, radix pseudostellariae 35g～45g, yncaria stem with hooks 30g～40g, Chinese yam 20g～30g, mountain wax plum 25g～35g, wooden blue 25g～35g, meadow fescue 30g～40g, eleusine indica 25g～35g, white wine grass 30g～40g,Samson St Johswort 15g～25g, franzenbach rhubarb root and rhizome 20g～30g, date 20g～30g, seed of Chinese dodder 30g～40g, indigo plantPositive 40g～the 50g of cloth, sealwort 30g～40g, radix ranunculi ternati 25g～35g, parasitic loranthus 20g～30g, duckCelery 25g～35g and caulis lonicerae 15g～25g.

2. Chinese medicine preparation as claimed in claim 1, is characterized in that: each component in described Chinese medicine preparationWeight be respectively wilsonii 60g～65g, Radix Codonopsis 75g～80g, fruit of glossy privet 50g～55g, blackberry lily 35g～40g, coix seed 30g～35g, stem of noble dendrobium 35g～40g, coptis 60g～65g, cordate houttuynia 30g～35g,Wind-weed 35g～40g, madder 35g～40g, caulis bambusae in taenian 30g～35g, hairyvein agrimony 40g～45g, Radix Angelicae Sinensis 20g～25g, radix paeoniae rubrathe 30g～35g, chrysanthemum 35g～40g, curcuma zedoary 25g～30g, Selaginella tamariscina 30g～35g, crown princeGinseng 35g～40g, yncaria stem with hooks 30g～35g, Chinese yam 20g～25g, mountain wax plum 25g～30g, wooden blue 25g～30g, meadow fescue 30g～35g, eleusine indica 25g～30g, white wine grass 30g～35g, Samson St Johswort 15g～20g, franzenbach rhubarb root and rhizome 20g～25g, date 20g～25g, seed of Chinese dodder 30g～35g, aleppo avens 40g～45g,Sealwort 30g～35g, radix ranunculi ternati 30g～35g, parasitic loranthus 20g～25g, Japanese cryptotaenia stem and leaf 30g～35g and bearWinter rattan 20g～25g.

3. Chinese medicine preparation as claimed in claim 1 or 2, is characterized in that: each in described Chinese medicine preparationThe weight of component be respectively wilsonii 60g, Radix Codonopsis 75g, fruit of glossy privet 50g, blackberry lily 35g, coix seed 30g,Stem of noble dendrobium 35g, coptis 60g, cordate houttuynia 30g, wind-weed 35g, madder 35g, caulis bambusae in taenian 30g, hairyvein agrimony40g, Radix Angelicae Sinensis 25g, radix paeoniae rubrathe 35g, chrysanthemum 40g, curcuma zedoary 30g, Selaginella tamariscina 35g, radix pseudostellariae 40g, hookRattan 35g, Chinese yam 25g, mountain wax plum 30g, wooden blue 30g, meadow fescue 35g, eleusine indica 30g, white wine grass35g, Samson St Johswort 20g, franzenbach rhubarb root and rhizome 25g, date 25g, seed of Chinese dodder 35g, aleppo avens 45g, sealwort 35g,Radix ranunculi ternati 30g, parasitic loranthus 25g, Japanese cryptotaenia stem and leaf 30g and caulis lonicerae 20g.

4. Chinese medicine preparation as claimed in claim 1 or 2, is characterized in that: described Chinese medicine preparation preparationBecome capsule and oral liquid.

Described in claim 1 or 2 for preventing the Chinese medicine preparation of nasopharyngeal carcinoma radiation side reactionPreparation method, is characterized in that: the formulation of described Chinese medicine preparation is capsule, and preparation method is specially,

The first step, by blackberry lily, the coptis, cordate houttuynia, the wind-weed, caulis bambusae in taenian, hairyvein agrimony, chrysanthemum, mountain wax plum,Wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, radix ranunculi ternati, Japanese cryptotaenia stem and leaf and caulis lonicerae powder respectivelyBroken, mix in proportion, obtain mixture, add the water doubly with respect to mixture quality 7-9, soak 3-5After hour, distill 3-5 hour, collect volatile oil, the dregs of a decoction are for subsequent use;

Second step, pulverizes remaining component respectively, puts into continuous extraction and fills with, then add the first step to obtainThe dregs of a decoction, adding determining alcohol is the alcohol extract 3-5 hour of 70%-80%, described in the amount of alcohol adding isDoubly, extract filters the 3-5 of the each bulk drug quality of Chinese medicine preparation sum, relative when filtrate is concentrated into 65 DEG CDensity is 1.25～1.30 lotion, lets cool;

The 3rd step, gets the above-mentioned lotion of 500g, adds the excipient starch of 1kg-2kg to be mixed into softwood, mistakeSieve series grain and in 55-65 DEG C dry, after whole grain, obtain particle, then the volatile oil that adds the first step to obtain,Encapsulated.

Described in claim 1 or 2 for preventing the Chinese medicine preparation of nasopharyngeal carcinoma radiation side reactionPreparation method, is characterized in that: the formulation of described Chinese medicine preparation is oral liquid, and preparation method is specially,

The first step, by blackberry lily, the coptis, cordate houttuynia, the wind-weed, caulis bambusae in taenian, hairyvein agrimony, chrysanthemum, mountain wax plum,Wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, radix ranunculi ternati, Japanese cryptotaenia stem and leaf and caulis lonicerae powder respectivelyBroken, mix in proportion, obtain mixture, add the water doubly with respect to mixture quality 7-9, soak 3-5After hour, distill 3-5 hour, collect volatile oil, the dregs of a decoction are for subsequent use;

Second step, pulverizes remaining component respectively, puts into continuous extraction and fills with, then add the first step to obtainThe dregs of a decoction, extracting in water 3-5 hour, the water yield adding be the each bulk drug quality of described Chinese medicine preparation itWith 6-8 doubly, extract filters, relative density 1.10-1.12 while being concentrated into 60 DEG C, static 24 hours,Relative density 1.04 when getting supernatant recovery ethanol and being concentrated into 20 DEG C, leaves standstill 48 hours, gets supernatantFilter, volatile oil, Tween-80 and appropriate flavouring that filtrate adds the first step to prepare, adjust volume extremely1000ml, filters, packing, and sterilizing, obtains described oral liquid.

7. for preventing a Traditional Chinese medicine preparation capsule agent for nasopharyngeal carcinoma radiation side reaction, its feature existsIn: bulk drug by wilsonii, Radix Codonopsis, the fruit of glossy privet, blackberry lily, coix seed, the stem of noble dendrobium, the coptis, cordate houttuynia,The wind-weed, madder, caulis bambusae in taenian, hairyvein agrimony, Radix Angelicae Sinensis, the radix paeoniae rubrathe, chrysanthemum, curcuma zedoary, Selaginella tamariscina, radix pseudostellariae, hookRattan, Chinese yam, mountain wax plum, wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, franzenbach rhubarb root and rhizome, largeJujube, the seed of Chinese dodder, aleppo avens, sealwort, radix ranunculi ternati, parasitic loranthus, Japanese cryptotaenia stem and leaf and caulis lonicerae form;

The weight of each bulk drug be respectively wilsonii 55g～65g, Radix Codonopsis 70g～80g, fruit of glossy privet 45g～55g, blackberry lily 30g～40g, coix seed 25g～35g, stem of noble dendrobium 30g～40g, coptis 55g～65g, fishRaw meat grass 25g～35g, wind-weed 30g～40g, madder 30g～40g, caulis bambusae in taenian 25g～35g, hairyvein agrimony 35g～45g, Radix Angelicae Sinensis 20g～30g, radix paeoniae rubrathe 30g～40g, chrysanthemum 35g～45g, curcuma zedoary 25g～35g, Selaginella tamariscina30g～40g, radix pseudostellariae 35g～45g, yncaria stem with hooks 30g～40g, Chinese yam 20g～30g, mountain wax plum 25g～35g, wooden blue 25g～35g, meadow fescue 30g～40g, eleusine indica 25g～35g, white wine grass 30g～40g,Samson St Johswort 15g～25g, franzenbach rhubarb root and rhizome 20g～30g, date 20g～30g, seed of Chinese dodder 30g～40g, indigo plantPositive 40g～the 50g of cloth, sealwort 30g～40g, radix ranunculi ternati 25g～35g, parasitic loranthus 20g～30g, duckCelery 25g～35g and caulis lonicerae 15g～25g;

The preparation method of described capsule is specially,

The first step, by blackberry lily, the coptis, cordate houttuynia, the wind-weed, caulis bambusae in taenian, hairyvein agrimony, chrysanthemum, mountain wax plum,Wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, radix ranunculi ternati, Japanese cryptotaenia stem and leaf and caulis lonicerae powder respectivelyBroken, mix in proportion, obtain mixture, add the water doubly with respect to mixture quality 7-9, soak 3-5After hour, distill 3-5 hour, collect volatile oil, the dregs of a decoction are for subsequent use;

Second step, pulverizes remaining component respectively, puts into continuous extraction and fills with, then add the first step to obtainThe dregs of a decoction, adding determining alcohol is the alcohol extract 3-5 hour of 70%-80%, described in the amount of alcohol adding isDoubly, extract filters the 3-5 of the each bulk drug quality of Chinese medicine preparation sum, relative when filtrate is concentrated into 65 DEG CDensity is 1.25～1.30 lotion, lets cool;

The 3rd step, gets the above-mentioned lotion of 500g, adds the excipient starch of 1kg-2kg to be mixed into softwood, mistakeSieve series grain and in 55-65 DEG C dry, after whole grain, obtain particle, then the volatile oil that adds the first step to obtain,Encapsulated.

8. for preventing a Chinese medicine preparation oral liquid for nasopharyngeal carcinoma radiation side reaction, its feature existsIn: bulk drug by wilsonii, Radix Codonopsis, the fruit of glossy privet, blackberry lily, coix seed, the stem of noble dendrobium, the coptis, cordate houttuynia,The wind-weed, madder, caulis bambusae in taenian, hairyvein agrimony, Radix Angelicae Sinensis, the radix paeoniae rubrathe, chrysanthemum, curcuma zedoary, Selaginella tamariscina, radix pseudostellariae, hookRattan, Chinese yam, mountain wax plum, wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, franzenbach rhubarb root and rhizome, largeJujube, the seed of Chinese dodder, aleppo avens, sealwort, radix ranunculi ternati, parasitic loranthus, Japanese cryptotaenia stem and leaf and caulis lonicerae form;

The weight of each bulk drug be respectively wilsonii 55g～65g, Radix Codonopsis 70g～80g, fruit of glossy privet 45g～55g, blackberry lily 30g～40g, coix seed 25g～35g, stem of noble dendrobium 30g～40g, coptis 55g～65g, fishRaw meat grass 25g～35g, wind-weed 30g～40g, madder 30g～40g, caulis bambusae in taenian 25g～35g, hairyvein agrimony 35g～45g, Radix Angelicae Sinensis 20g～30g, radix paeoniae rubrathe 30g～40g, chrysanthemum 35g～45g, curcuma zedoary 25g～35g, Selaginella tamariscina30g～40g, radix pseudostellariae 35g～45g, yncaria stem with hooks 30g～40g, Chinese yam 20g～30g, mountain wax plum 25g～35g, wooden blue 25g～35g, meadow fescue 30g～40g, eleusine indica 25g～35g, white wine grass 30g～40g,Samson St Johswort 15g～25g, franzenbach rhubarb root and rhizome 20g～30g, date 20g～30g, seed of Chinese dodder 30g～40g, indigo plantPositive 40g～the 50g of cloth, sealwort 30g～40g, radix ranunculi ternati 25g～35g, parasitic loranthus 20g～30g, duckCelery 25g～35g and caulis lonicerae 15g～25g;

The preparation method of described Chinese medicine preparation oral liquid is specially,

The first step, by blackberry lily, the coptis, cordate houttuynia, the wind-weed, caulis bambusae in taenian, hairyvein agrimony, chrysanthemum, mountain wax plum,Wood indigo plant, meadow fescue, eleusine indica, white wine grass, Samson St Johswort, radix ranunculi ternati, Japanese cryptotaenia stem and leaf and caulis lonicerae powder respectivelyBroken, mix in proportion, obtain mixture, add the water doubly with respect to mixture quality 7-9, soak 3-5After hour, distill 3-5 hour, collect volatile oil, the dregs of a decoction are for subsequent use;

Second step, pulverizes remaining component respectively, puts into continuous extraction and fills with, then add the first step to obtainThe dregs of a decoction, extracting in water 3-5 hour, the water yield adding be the each bulk drug quality of described Chinese medicine preparation itWith 6-8 doubly, extract filters, relative density 1.10-1.12 while being concentrated into 60 DEG C, static 24 hours,Relative density 1.04 when getting supernatant recovery ethanol and being concentrated into 20 DEG C, leaves standstill 48 hours, gets supernatantFilter, volatile oil, Tween-80 and appropriate flavouring that filtrate adds the first step to prepare, adjust volume extremely1000ml, filters, packing, and sterilizing, obtains described oral liquid.