CN112370490A - Polysaccharide antibacterial gel and preparation method thereof - Google Patents

Abstract

The application relates to the field of gynecological gel, and particularly discloses polysaccharide antibacterial gel and a preparation method thereof, wherein the polysaccharide antibacterial gel is prepared from the following raw materials in parts by weight: 0.1-0.2 parts of collagen peptide; 1-2 parts of bletilla striata polysaccharide; 0.5-1.5 parts of dendrobium polysaccharide; 2-3 parts of wolfberry polysaccharide; 15-20 parts of plant extract; 0.5-1 part of human-like collagen; 0.1-0.2 part of plant essential oil; 0.05-0.1 part of benzalkonium bromide; 1-2 parts of carbomer; 0.5-1 part of glycerol; 1-2 parts of a pH regulator; 0.5-1.5 parts of emulsifier; purified water is made up to 100 parts. The polysaccharide bacteriostatic gel can be used for gynecological bacteriostasis and has the advantage of good bacteriostatic effect.

Description

Polysaccharide antibacterial gel and preparation method thereof

Technical Field

The application relates to the field of gynecological gel, in particular to polysaccharide antibacterial gel and a preparation method thereof.

Background

The gynecological gel is a gynecological medicine, is a gel, is used for treating various gynecological vaginitis and cervicitis, and comprises the following components: bacterial vaginitis, trichomonas vaginitis, mixed vaginitis, gonococcal infection and chronic cervicitis. Has antiinflammatory, antibacterial, and antipruritic effects. Has obvious inhibiting effect on the growth of pathogenic microorganisms such as staphylococcus aureus, escherichia coli, gonococcus, candida albicans, fungi, saccharomycetes and the like.

The related technology discloses an antibacterial gel, which comprises epsilon-polylysine, chitosan quaternary ammonium salt and carbomer in a mass ratio of 1: 1-5: 5-50, wherein the gel further comprises a proper amount of solvent consisting of glycerol and water, and the solvent is prepared from glycerol and water in a volume ratio of 1-3: 5.

In view of the above-mentioned related technologies, the inventors consider that the bacteriostatic effect of the bacteriostatic gel is to be improved.

Disclosure of Invention

In order to improve the bacteriostatic effect of the bacteriostatic gel, the application provides a polysaccharide bacteriostatic gel and a preparation method thereof.

In a first aspect, the application provides a polysaccharide bacteriostatic gel, which adopts the following technical scheme:

the polysaccharide bacteriostatic gel is prepared from the following raw materials in parts by weight:

0.1-0.2 parts of collagen peptide;

1-2 parts of bletilla striata polysaccharide;

0.5-1.5 parts of dendrobium polysaccharide;

2-3 parts of wolfberry polysaccharide;

15-20 parts of plant extract;

0.5-1 part of human-like collagen;

0.1-0.2 part of plant essential oil;

0.05-0.1 part of benzalkonium bromide;

1-2 parts of carbomer;

0.5-1 part of glycerol;

1-2 parts of a pH regulator;

0.5-1.5 parts of emulsifier;

purified water is made up to 100 parts.

By adopting the technical scheme, as the bletilla striata polysaccharide, the dendrobe polysaccharide and the lycium barbarum polysaccharide are compounded, the bletilla striata polysaccharide has a certain inhibition effect on common staphylococcus aureus, escherichia coli and candida albicans, the dendrobe polysaccharide has a remarkable inhibition effect on escherichia coli, staphylococcus aureus, bacillus subtilis and candida albicans, and the lycium barbarum polysaccharide has a certain inhibition effect on staphylococcus aureus, escherichia coli, candida albicans and aspergillus niger.

Optionally, the plant extract is prepared from the following raw materials in parts by weight:

10-12 parts of sophora flavescens;

6-9 parts of phellodendron;

2-5 parts of fructus cnidii;

4-8 parts of salvia miltiorrhiza;

4-8 parts of safflower;

4-8 parts of motherwort;

2-4 parts of folium artemisiae argyi.

By adopting the technical scheme, the traditional Chinese medicine plants contain bacteriostatic effective components, so that the three pathogenic bacteria can be effectively inhibited when the traditional Chinese medicine plants are compounded for use, the cell activity of female private parts can be activated, the tissue repair capacity can be promoted, and the private parts are healthier, more compact and more moist.

Optionally, the polysaccharide bacteriostatic gel is prepared from the following raw materials in parts by weight:

0.15 part of collagen peptide;

1 part of bletilla striata polysaccharide;

0.5 part of dendrobium polysaccharide;

2.5 parts of wolfberry polysaccharide;

17 parts of plant extract;

0.7 part of human-like collagen;

0.16 part of plant essential oil;

0.07 part of benzalkonium bromide;

1.5 parts of carbomer;

0.7 part of glycerol;

1 part of pH regulator;

1 part of an emulsifier;

purified water is complemented to 100 parts;

the plant extract is prepared from the following raw materials in parts by weight:

11 parts of sophora flavescens;

8 parts of phellodendron;

3 parts of fructus cnidii;

5 parts of salvia miltiorrhiza;

6 parts of safflower;

7 parts of motherwort;

3 parts of folium artemisiae argyi.

By adopting the technical scheme, the gel has a good antibacterial effect when the raw materials are in the specific proportion.

Optionally, the plant essential oil consists of tea tree essential oil, geranium essential oil and cananga odorata essential oil.

By adopting the technical scheme, the tea tree essential oil is an extract of tea trees, and has the effects of resisting bacteria and diminishing inflammation, astringing pores, improving dysmenorrheal, irregular menstruation, genital infection and the like. Has strong inhibiting effect on trichomonas, mould and the three pathogenic bacteria. The geranium essential oil has the functions of relieving pain, astringing, resisting bacteria and promoting the regeneration of skin cells. The cananga odorata essential oil is an extract from cananga odorata, has the effects of resisting melancholy, resisting bacteria, calming and the like, and can shrink pores, moisten skin and regulate internal secretion. When the tea tree essential oil, the geranium essential oil and the cananga odorata essential oil are used in combination, the bacteriostasis rate can be improved.

Optionally, the plant essential oil is prepared from tea tree essential oil, geranium essential oil and cananga odorata essential oil in a weight ratio of 1: (0.4-0.8): (0.2-0.6).

By adopting the technical scheme, the tea tree essential oil, the geranium essential oil and the cananga odorata essential oil can be synergized under a specific proportion, so that the bacteriostasis rate is obviously improved.

Optionally, the paint also comprises 1-3 parts of a cross-linking agent.

By adopting the technical scheme, the polysaccharide and the peptide in the gel have water absorption, swell after absorbing water, can be crosslinked with each other after adding the crosslinking agent to form a 3D framework, can wrap the active ingredients in the gel, play a role in slow release, and fully play a role in inhibiting bacteria of the gel on the vagina.

Optionally, the cross-linking agent is selected from at least two of carrageenan, xanthan gum and locust bean gum.

By adopting the technical scheme, when the at least two cross-linking agents are compounded for use, the synergistic effect can be realized, and the release speed of the antibacterial component can be prolonged.

In a second aspect, the application provides a preparation method of polysaccharide bacteriostatic gel, which adopts the following technical scheme:

a preparation method of polysaccharide bacteriostatic gel comprises the following steps:

firstly, adding a proper amount of purified water into benzalkonium bromide, and dissolving to obtain a first solution;

step two, weighing the plant extract;

dissolving carbomer, collagen peptide, bletilla striata polysaccharide, dendrobe polysaccharide, lycium barbarum polysaccharide and human-like collagen in a proper amount of purified water, standing for 10-12 hours to fully swell carbomer, and uniformly stirring to obtain a gel matrix;

step four, diluting the plant essential oil and the glycerol with a proper amount of ethanol, adding an emulsifier, and uniformly stirring to obtain an essential oil mixture;

and step five, adding the mixture of the first solution, the plant extract and the essential oil into the gel matrix, uniformly stirring, adding purified water to a sufficient amount, slowly adding a pH regulator under a stirring state until the pH is 4-6, and uniformly stirring to obtain the gel.

By adopting the technical scheme, the components are uniformly dispersed to obtain hydrophilic gel, the polysaccharide and the collagen peptide in the gel swell after absorbing water to form a 3D framework, and active ingredients are wrapped in the gel, so that the gel has the functions of resisting bacteria, resisting trichomonas, relieving itching, activating cell vitality of female private parts, promoting tissue repair capacity and the like, and the private parts are healthier, more compact and more moist.

In summary, the present application has the following beneficial effects:

1. because this application adopts bletilla striata polysaccharide, dendrobe polysaccharide, matrimony vine polysaccharide to use in coordination, can the synergistic interaction, show improvement antibacterial rate.

2. The tea tree essential oil, the geranium essential oil and the cananga odorata essential oil are preferably adopted in the application and are used in a compounding mode, so that the synergistic effect can be achieved, and the bacteriostatic rate is further improved.

Detailed Description

The present application will be described in further detail with reference to examples.

Examples

Example 1

A polysaccharide antibacterial gel is prepared from the raw materials shown in Table 1. The preparation method of the polysaccharide bacteriostatic gel comprises the following steps:

firstly, adding 10g of purified water into benzalkonium bromide, and dissolving to obtain a first solution;

pulverizing radix sophorae flavescentis, golden cypress, fructus cnidii, salvia miltiorrhiza, safflower, leonurus and folium artemisiae argyi into coarse powder, extracting by using a percolation method, using 55% ethanol as a solvent, adding 3 times of ethanol by weight of the coarse powder for the first time, soaking for 5 days, slowly percolating, adding 3 times of ethanol by weight of the coarse powder for the second time, soaking for 3 days, slowly percolating, squeezing medicine residues, combining 2 times of percolate, mixing uniformly, decoloring by using active carbon, recovering and standing for 24 hours, recovering ethanol, and concentrating until the relative density is 1.08-1.10 at 60 ℃ to obtain a plant extract;

dissolving carbomer, collagen peptide, bletilla striata polysaccharide, dendrobium polysaccharide, lycium barbarum polysaccharide and human-like collagen in 25g of purified water, standing for 10 hours to fully swell carbomer, and uniformly stirring to obtain a gel matrix;

step four, adding 3g of ethanol into the plant essential oil and the glycerol for dilution, adding an emulsifier, and uniformly stirring to obtain an essential oil mixture;

and step five, adding the mixture of the first solution, the plant extract and the essential oil into the gel matrix, uniformly stirring, adding purified water to a sufficient amount, slowly adding a pH regulator to a pH value of 6 under a stirring state, and uniformly stirring to obtain the gel.

The collagen peptide is purchased from Spanish Riptotay, the human-like collagen is purchased from Jiangsu Jiangshan gathering biotechnology limited, the plant essential oil is tea tree essential oil, the tea tree essential oil is purchased from Guangzhou Wuzhitang Biotechnology limited, the pH regulator is triethanolamine, the emulsifier is Tween 80, the dendrobium polysaccharide is dendrobium officinale polysaccharide which is also called dendrobium officinale extract, and the bletilla polysaccharide, the dendrobium polysaccharide and the lycium polysaccharide are purchased from Shaanxi Huike plant development limited.

The plant extract is prepared from the following raw materials in parts by weight: 2g of radix sophorae flavescentis; 4g of phellodendron amurense; fructus cnidii 4 g; 6g of salvia miltiorrhiza; 6g of safflower; 1g of motherwort; 1g of folium artemisiae argyi.

Examples 2 to 3

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel prepared from the raw materials shown in the table 1.

TABLE 1 materials and weights (g) thereof in examples 1-3

Raw materials	Example 1	Example 2	Example 3
				Collagen peptide	0.1	0.15	0.2
Bletilla striata polysaccharide	1	1.5	2
				Dendrobium polysaccharide	1.5	1	0.5
Lycium barbarum polysaccharides	2	2.5	3
				Plant extracts	15	18	20
Human-like collagen	0.5	0.8	1
				Plant essential oil	0.2	0.15	0.1
Benzalkonium bromide	0.1	0.08	0.05
				Carbomer	1	1.5	2
Glycerol	1	0.8	0.5
				pH regulator	1	1.5	2
Emulsifier	0.5	1	1.5
				Purified water	Make up to 100g	Make up to 100g	Make up to 100g

Example 4

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 1 in that a plant extract is prepared from the following raw materials in parts by weight: 10 parts of sophora flavescens; 6 parts of phellodendron; 2 parts of fructus cnidii; 4 parts of salvia miltiorrhiza; 4 parts of safflower; 4 parts of motherwort; and 2 parts of folium artemisiae argyi.

Example 5

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 1 in that a plant extract is prepared from the following raw materials in parts by weight: 11 parts of sophora flavescens; 8 parts of phellodendron; 4 parts of fructus cnidii; 6 parts of salvia miltiorrhiza; 5 parts of safflower; 8 parts of motherwort; 3 parts of folium artemisiae argyi.

Example 6

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 1 in that a plant extract is prepared from the following raw materials in parts by weight: 12 parts of sophora flavescens; 9 parts of phellodendron; 5 parts of fructus cnidii; 8 parts of salvia miltiorrhiza; 8 parts of safflower; 8 parts of motherwort; 4 parts of folium artemisiae argyi.

Example 7

A polysaccharide bacteriostatic gel, which is different from the polysaccharide bacteriostatic gel in example 1 in that the plant essential oil is geranium essential oil, which is purchased from Wuzhitang Biotech limited, Guangzhou.

Example 8

A polysaccharide bacteriostatic gel, which is different from the gel of example 1 in that the plant essential oil is cananga essential oil, which is obtained from Wuzhitang Biotech Co., Ltd, Guangzhou.

Example 9

A polysaccharide bacteriostatic gel, which is different from that in example 1 in that the plant essential oil is composed of 0.091g of tea tree essential oil, 0.091g of geranium essential oil and 0.018g of ylang-ylang essential oil.

Example 10

A polysaccharide bacteriostatic gel, which is different from that of example 1 in that the plant essential oil is composed of 0.143g of tea tree essential oil, 0.029g of geranium essential oil and 0.029g of ylang-ylang essential oil.

Example 11

A polysaccharide bacteriostatic gel, which is different from that in example 1 in that the plant essential oil is composed of 0.125g of tea tree essential oil, 0.05g of geranium essential oil and 0.025g of ylang-ylang essential oil.

Example 12

A polysaccharide bacteriostatic gel, which is different from that of example 1 in that the plant essential oil is composed of 0.083g of tea tree essential oil, 0.067g of geranium essential oil and 0.05g of ylang-ylang essential oil.

Example 13

The polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 1 in that the polysaccharide bacteriostatic gel is prepared from the following raw materials in parts by weight: 0.15g of collagen peptide; 1g of bletilla striata polysaccharide; 0.5g of dendrobium polysaccharide; 2.5g of lycium barbarum polysaccharide; 17g of plant extract; human-like collagen 0.7 g; 0.16g of plant essential oil; 0.07g of benzalkonium bromide; carbomer 1.5 g; 0.7g of glycerol; 1g of pH regulator; 1g of emulsifier; purified water is replenished to 100 g; the plant extract is prepared from the following raw materials in parts by weight: 11g of radix sophorae flavescentis; 8g of phellodendron amurense; 3g of fructus cnidii; 5g of salvia miltiorrhiza; 6g of safflower; 7g of motherwort herb; 3g of folium artemisiae argyi.

Example 14

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 4 in that 1g of a cross-linking agent is also added in the third step, and the cross-linking agent consists of 0.5g of carrageenan and 0.5g of xanthan gum.

Example 15

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 4 in that 2g of a cross-linking agent is also added in the third step, and the cross-linking agent consists of 1g of carrageenan and 1g of xanthan gum.

Example 16

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 4 in that 3g of a cross-linking agent is also added in the third step, and the cross-linking agent consists of 1.5g of carrageenan and 1.5g of xanthan gum.

Example 17

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 4 in that 1g of a cross-linking agent is also added in the step three, and the cross-linking agent consists of 0.5g of carrageenan and 0.5g of locust bean gum.

Example 18

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 4 in that 1g of a cross-linking agent is also added in the step three, and the cross-linking agent consists of 0.5g of xanthan gum and 0.5g of locust bean gum.

Example 19

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 4 in that 1g of a cross-linking agent is also added in the step three, and the cross-linking agent consists of 0.33g of carrageenan, 0.33g of xanthan gum and 0.33g of locust bean gum.

Example 20

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in the embodiment 4 in that 1g of a cross-linking agent is also added in the step three, and the cross-linking agent is carrageenan.

Example 21

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 4 in that 1g of a cross-linking agent is also added in the third step, and the cross-linking agent is xanthan gum.

Example 22

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in example 4 in that 1g of a cross-linking agent is also added in the step three, and the cross-linking agent is locust bean gum.

Comparative example

Comparative example 1

An antibacterial gel, which comprises the following components: 0.2g of epsilon-polylysine, 0.4g of chitosan quaternary ammonium salt, 1.5g of carbomer, 20ml of glycerol, 8ml of 10% citric acid monohydrate aqueous solution, 3ml of triethanolamine and 50ml of water; the pH of the gel was 6.1. The preparation method of the gel specifically comprises the following steps:

(1) adding 1.5g carbomer into 50ml water, stirring, and standing to fully swell;

(2) adding 0.4g of chitosan quaternary ammonium salt and 0.2g of epsilon-polylysine into 20ml of glycerol, fully stirring, adding triethanolamine and adjusting the pH value to 7.1;

(3) adding the fully swollen carbomer in the step (1) into the product obtained in the step (2), and continuously stirring to obtain a gel-like mixture;

(4) adding 10% citric acid monohydrate aqueous solution dropwise into the above gel-like mixture, and stirring continuously to obtain gel with pH of 6.1.

Comparative example 2

An antibacterial gel is different from the antibacterial gel in example 1 in that collagen peptide, bletilla striata polysaccharide, dendrobe polysaccharide, lycium barbarum polysaccharide, plant extract, human-like collagen, plant essential oil and benzalkonium bromide are not added into the raw materials.

Comparative example 3

A polysaccharide antibacterial gel is different from comparative example 1 in that 4.5g of bletilla striata polysaccharide is added into the raw materials.

Comparative example 4

A polysaccharide antibacterial gel is different from the polysaccharide antibacterial gel in comparative example 1 in that 4.5g of dendrobe polysaccharide is added into the raw materials.

Comparative example 5

A polysaccharide antibacterial gel is different from comparative example 1 in that 4.5g of Lycium barbarum polysaccharide is added into the raw materials.

Comparative example 6

A polysaccharide bacteriostatic gel is different from the polysaccharide bacteriostatic gel in comparative example 1 in that 1g of bletilla striata polysaccharide, 1.5g of dendrobe polysaccharide and 2g of wolfberry polysaccharide are added into raw materials.

Performance test

Test method

(1) The gels of examples 1-13 and comparative examples 1-6 were tested for their bacteriostatic rate against E.coli (8099), Candida albicans (ATCC10231) and Staphylococcus aureus (ATCC6538) for 10min according to the test conditions in GB15979-2002, appendix C4 of hygienic Standard for Disposable sanitary articles and 2002, with the tests repeated three times, the mean value being taken, the bacteriostatic test being a vehicle test, the test temperature being 20 ℃. + -. 1 ℃.

(2) According to test conditions in GB15979-2002 hygienic Standard for Disposable sanitary articles appendix C4 and 2002 edition 2002, the gels in examples 4-6, 14-22 and comparative example 1 were tested for their bacteriostatic rate on Escherichia coli (8099) for 5min, 10min, 20min and 25min, the tests were repeated three times, the mean value was taken, the bacteriostatic test was a carrier test, and the test temperature was 20 ℃. + -. 1 ℃.

TABLE 2 results of the bacteriostatic test for examples 1-13 and comparative examples 1-6

TABLE 3 results of experiments on the bacteriostatic ratio of examples 4-6, examples 14-22 and comparative example 1 to E.coli at different times

By combining the examples 1-13 and the comparative examples 1-6 and combining the table 2, it can be seen that the bacteriostatic rates of the examples 1-3, which adopt the bletilla striata polysaccharide, the dendrobe polysaccharide and the lycium barbarum polysaccharide to compound, on three pathogenic bacteria are all above 80%, which indicates that the bacteriostatic gel has a strong bacteriostatic action. The raw materials of the plant extracts in examples 4 to 6 have a certain improvement in bacteriostatic rate within the range of the present application, which indicates that the raw materials of the plant extracts can improve the bacteriostatic rate at a specific ratio.

The bacteriostasis rate of the gel in the comparative example 1 is about 60%, which shows that the bacteriostasis effect of the gel in the comparative example 1 needs to be improved. The comparative example 2 is that when the antibacterial component is not added, the antibacterial rate is 0%, the comparative example 3 is that after the bletilla striata polysaccharide is added on the basis of the comparative example 2, the antibacterial rate is about 53%, the comparative example 4 is that after the dendrobe polysaccharide is added on the basis of the comparative example 2, the antibacterial rate is about 50%, and the comparative example 5 is that after the lycium barbarum polysaccharide is added on the basis of the comparative example 2, the antibacterial rate is about 50%, which indicates that the bletilla striata polysaccharide, the dendrobe polysaccharide and the lycium barbarum polysaccharide have certain antibacterial action; comparative example 6 when bletilla striata polysaccharide, dendrobe polysaccharide and lycium barbarum polysaccharide are added simultaneously on the basis of comparative example 2, the bacteriostasis rate is about 61%, which shows that the bletilla striata polysaccharide, dendrobe polysaccharide and lycium barbarum polysaccharide can be synergized when used in a compounding manner, and the bacteriostasis rate is remarkably improved.

In example 1, the bacteriostatic rate is about 82% when only tea tree essential oil is added, about 81% when only geranium essential oil is added in example 7, about 81% when only ylang-ylang essential oil is added in example 8, and slightly increased when three essential oils are simultaneously added in examples 9-10; in the examples 11 to 12, when the ratio of the three essential oils is within the range of the application, the bacteriostatic rate is obviously improved, which shows that the tea tree essential oil, the geranium essential oil and the ylang-ylang essential oil can be synergistic under a specific ratio, and the bacteriostatic rate is obviously improved.

As can be seen by combining examples 4-6, 14-22 and comparative example 1 and table 3, the inhibition rate of examples 4-6 to Escherichia coli at 20min reaches 88%, the inhibition rate is not increased substantially at 25min, the inhibition rate of comparative example 1 to Escherichia coli at 20min also reaches 61.5%, the inhibition rate is not increased substantially at 25min, and the common gel has no slow release effect. Example 14 when carrageenan and xanthan gum are added as cross-linking agents, the bacteriostatic rate of the gel increases to 90% at 25min, which shows that the release rate of the bacteriostatic component can be prolonged by compounding the carrageenan and the xanthan gum as the cross-linking agents, example 17 when carrageenan and locust bean gum are added as the cross-linking agents, the bacteriostatic rate of the gel increases to 90.1% at 25min, example 18 when xanthan gum and locust bean gum are added as the cross-linking agents, the bacteriostatic rate of the gel increases to 90% at 25min, example 19 when carrageenan, xanthan gum and locust bean gum are added as the cross-linking agents, the bacteriostatic rate of the gel increases to 90.5% at 25 min; in examples 20 to 22, when carrageenan, xanthan gum and locust bean gum are used as the crosslinking agent alone, the bacteriostatic rate of the gel is not increased at 25min, which indicates that the crosslinking agent is at least two of carrageenan, xanthan gum and locust bean gum, which can be synergistic and can prolong the release rate of the bacteriostatic component.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims (8)

1. The polysaccharide bacteriostatic gel is characterized by being prepared from the following raw materials in parts by weight:

0.1-0.2 parts of collagen peptide;

1-2 parts of bletilla striata polysaccharide;

0.5-1.5 parts of dendrobium polysaccharide;

2-3 parts of wolfberry polysaccharide;

15-20 parts of plant extract;

0.5-1 part of human-like collagen;

0.1-0.2 part of plant essential oil;

0.05-0.1 part of benzalkonium bromide;

1-2 parts of carbomer;

0.5-1 part of glycerol;

1-2 parts of a pH regulator;

0.5-1.5 parts of emulsifier;

purified water is made up to 100 parts.

2. A polysaccharide bacteriostatic gel according to claim 1, wherein: the plant extract is prepared from the following raw materials in parts by weight:

10-12 parts of sophora flavescens;

6-9 parts of phellodendron;

2-5 parts of fructus cnidii;

4-8 parts of salvia miltiorrhiza;

4-8 parts of safflower;

4-8 parts of motherwort;

2-4 parts of folium artemisiae argyi.

3. A polysaccharide bacteriostatic gel according to claim 2, wherein: the polysaccharide bacteriostatic gel is prepared from the following raw materials in parts by weight:

0.15 part of collagen peptide;

1 part of bletilla striata polysaccharide;

0.5 part of dendrobium polysaccharide;

2.5 parts of wolfberry polysaccharide;

17 parts of plant extract;

0.7 part of human-like collagen;

0.16 part of plant essential oil;

0.07 part of benzalkonium bromide;

1.5 parts of carbomer;

0.7 part of glycerol;

1 part of pH regulator;

1 part of an emulsifier;

purified water is complemented to 100 parts;

the plant extract is prepared from the following raw materials in parts by weight:

11 parts of sophora flavescens;

8 parts of phellodendron;

3 parts of fructus cnidii;

5 parts of salvia miltiorrhiza;

6 parts of safflower;

7 parts of motherwort;

3 parts of folium artemisiae argyi.

4. A polysaccharide bacteriostatic gel according to claim 1, wherein: the plant essential oil consists of tea tree essential oil, geranium essential oil and cananga odorata essential oil.

5. A polysaccharide bacteriostatic gel according to claim 4, wherein: the plant essential oil is prepared from tea tree essential oil, geranium essential oil and cananga odorata essential oil in a weight part ratio of 1: (0.4-0.8): (0.2-0.6).

6. A polysaccharide bacteriostatic gel according to claim 1, wherein: also comprises 1-3 parts of cross-linking agent.

7. A polysaccharide bacteriostatic gel according to claim 6, wherein: the cross-linking agent is at least two selected from carrageenan, xanthan gum and locust bean gum.

8. A process for preparing a polysaccharide bacteriostatic gel according to any one of claims 1 to 7, wherein: the method comprises the following steps:

firstly, adding a proper amount of purified water into benzalkonium bromide, and dissolving to obtain a first solution;

step two, weighing the plant extract;

dissolving carbomer, collagen peptide, bletilla striata polysaccharide, dendrobe polysaccharide, lycium barbarum polysaccharide and human-like collagen in a proper amount of purified water, standing for 10-12 hours to fully swell carbomer, and uniformly stirring to obtain a gel matrix;

step four, diluting the plant essential oil and the glycerol with a proper amount of ethanol, adding an emulsifier, and uniformly stirring to obtain an essential oil mixture;

and step five, adding the mixture of the first solution, the plant extract and the essential oil into the gel matrix, uniformly stirring, adding purified water to a sufficient amount, slowly adding a pH regulator under a stirring state until the pH is 4-6, and uniformly stirring to obtain the gel.