CN109876051A - A kind of gynecological gel and preparation method thereof - Google Patents
A kind of gynecological gel and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of gynecological gel and preparation method thereof, the raw material components of the gynecological gel include: traditional Chinese medicinal components 0.5-1 parts by weight, poly hexamethylene biguanide 0.015-0.02 parts by weight, borneol 0.1-0.4 parts by weight, menthol 0.1-0.4 parts by weight, thymol 2-5 parts by weight, carbomer 0.2-0.5 parts by weight, glycerol 4-8 parts by weight；The traditional Chinese medicinal components include the mixture that safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis are formed by weight 5-20:10-25:15-25:10-20:5-15:5-10:5-10.The present invention is compounded by the traditional Chinese medicinal components that ad hoc approach is prepared with poly hexamethylene biguanide, thymol, so that various drug interactions, treat vagina inflammation significant effect, the present invention it is safe and non-stimulating, quality it is reliable and stable and be discontinued after it is uneasy to recur.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, and in particular to a kind of gynecological gel and preparation method thereof.
Background technique
Female gynecological colpitis mainly include bacterial vaginitis, colpomycosis, trichomonas vaginitis disease and
Combination vaginitis etc..In traditional therapy, the medicament categories in terms of Chinese medicine external suppository, lotion are various, still, at present
These traditional Chinese medicine for external application, mostly use decocting liquid to be concentrated or alcohol soak extraction active ingredient of Chinese herbs, it is effectively living in extract
Property component content it is lower, fungistatic effect is unobvious, and treat after be easy recurrence.
Summary of the invention
In order to solve the above-mentioned problems in the prior art, the present invention is not easy after providing a kind of good antimicrobial effect, treatment
Recurrence, the gynecological gel for the treatment of both manifestation and root cause of disease and preparation method thereof.
The technical solution of the present invention is as follows:
A kind of gynecological gel, raw material components include: traditional Chinese medicinal components 0.5-1 parts by weight, poly hexamethylene biguanide 0.015-
0.02 parts by weight, borneol 0.1-0.4 parts by weight, menthol 0.1-0.4 parts by weight, thymol 2-5 parts by weight, carbomer 0.2-
0.5 parts by weight, glycerol 4-8 parts by weight；
The traditional Chinese medicinal components include safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis, the safflower, cnidium monnieri
Weight ratio between son, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis is 5-20:10-25:15-25:10-20:5-15:5-10:
5-10。
Further, the weight ratio between the safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis is 8-
15:15-22:18-22:12-18:8-12:7-9:7-9。
Further, the weight ratio between the safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis is 12:
18:20:15:10:8:8。
A method of the gynecological gel is prepared, is included the following steps:
(1) it is crushed after mixing safflower, Cortex Phellodendri, motherwort, ethyl alcohol is then added, first impregnated 5-9 days, then will be after dipping
Mixed raw material carries out diacolation with the speed of 0.5-5ml/kg/min, and after recycling ethyl alcohol, concentrated, ageing obtains Chinese medicine percolating liquid；
(2) will folium artemisiae argyi, Radix Angelicae Sinensis mix after crush, then plus water is decocted, after filter, obtain filtrate；It will be described
Filtrate is concentrated, and is then added ethyl alcohol in concentrate, after standing, is filtered to remove precipitating, filtrate recycling ethanol is simultaneously concentrated, obtains
Chinese medical concrete；
(3) by kuh-seng, frutus cnidii mix, then plus water is decocted, after filter；By filtered filtrate successively into
Row concentration, dry, crushing, obtain mixing traditional Chinese medicine powder；
(4) water is added into poly hexamethylene biguanide, is stirred to dissolve, then sequentially adds step (1) Chinese medicine and seeps
It filters liquid, step (2) described Chinese medical concrete, stirs evenly, obtain A phase；Borneol, menthol, thymol are mixed, are then added
Ethyl alcohol is stirred to dissolve, and obtains B phase；Tween 80 is added into step (3) the mixing traditional Chinese medicine powder, stirring makes to be uniformly mixed, obtain
To C phase；
(5) add water to make sufficiently to be swollen into carbomer, then sequentially add glycerol, A phase, B phase, adjust pH to 5-7, obtain solidifying
C phase is added in Xiang Suoshu gel-type vehicle, stirs evenly to get the gynecological gel for gel matrix.
Further, in step (1), the mass concentration of the ethyl alcohol is 95wt%, the smashed raw material and ethyl alcohol
Weight ratio be 1:1-3.
Further, in step (1), the time of the dipping is 7 days, and the speed of the diacolation is 3ml/kg/min, into
It is 1.08-1.10 that relative density is concentrated into described in row, and the ageing is standing 20-30h.
Further, in step (2), the weight ratio of the smashed raw material and water is 1:6-10, and the ethyl alcohol is added
Into concentrate, alcohol content is 60-80%, and the mass concentration of the ethyl alcohol is 95wt%, and the time of the standing is 24-36h,
The temperature of the standing is 4-8 DEG C.
Further, in step (3), the weight ratio of the mixed raw material and water is 1:6-8；The time of the decoction
For 1.5-2.5h；The temperature of the drying is 50-60 DEG C, and the time of the drying is 2-4h；The partial size that is crushed to is 100-
200 mesh.
Further, in step (4), the weight ratio of the poly hexamethylene biguanide and water is 1:1-2, the borneol, thin
The weight ratio of the mixed raw material of lotus brain, thymol and ethyl alcohol is 1:1-3, the weight ratio of the mixing traditional Chinese medicine powder and Tween 80
For 1:4-6.
Further, in step (5), the weight ratio of the carbomer and water is 1:200-400, and pH adjusting agent is three ethyl alcohol
Amine, the speed of the stirring are 1000-2000r/min.
The invention has the benefit that
1, gynecological gel of the present invention, including traditional Chinese medicinal components, poly hexamethylene biguanide and musk deer with bacteriostasis
Vanilla phenol, the traditional Chinese medicinal components include having the function of heat-clearing and damp-drying drug, the frutus cnidii of antibacterial desinsection, kuh-seng, Cortex Phellodendri, folium artemisiae argyi, with
And safflower, motherwort, Radix Angelicae Sinensis with warm palace promoting blood circulation effect.The present invention is by by traditional Chinese medicinal components and poly hexamethylene biguanide and musk deer
Vanilla phenol is compounded, so that various drug interactions, collaboration works, compared with using single antipathogenic composition, fungistatic effect
More preferably, and it is uneasy to recur after drug withdrawal.
2, gynecological gel of the present invention, traditional Chinese medicinal components therein have passed through specially treated, divide using by traditional Chinese medicinal components
It is 3 groups, is then prepared into Chinese medicine percolating liquid, Chinese medical concrete and the mode for mixing traditional Chinese medicine powder respectively, the reason of processing in this way, is,
Present inventor tests discovery by contrast, and the gynecological gel quality being prepared using the method for the present invention is more stable, antibacterial effect
Fruit is more preferable.
3, gynecological gel of the present invention, the confirmation of Via vagina mucomembranous pungency test is safe and non-stimulating, and suitable popularization is answered
With.
Specific embodiment
Below by specific embodiment, the invention will be further described.
1g is represented in following embodiment with 1 parts by weight.
Embodiment 1
The present embodiment provides a kind of gynecological gel, raw material components include:
0.5 parts by weight of traditional Chinese medicinal components, 0.015 parts by weight of poly hexamethylene biguanide, 0.1 parts by weight of borneol, 0.1 weight of menthol
Measure part, 2 parts by weight of thymol, 0.2 parts by weight of carbomer, 4 parts by weight of glycerol；
The traditional Chinese medicinal components include safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis, the safflower, cnidium monnieri
Weight ratio between son, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis is 5:10:15:10:5:5:5.
Further, a kind of method preparing the gynecological gel is provided, is included the following steps:
(1) it is crushed after mixing safflower, Cortex Phellodendri, motherwort, then 95% ethyl alcohol of the quality such as addition, first impregnates 5 days, then
Mixed raw material after dipping is subjected to diacolation with the speed of 0.5ml/kg/min, after recycling ethyl alcohol, being concentrated into relative density is
1.08,20h is stood, Chinese medicine percolating liquid is obtained；
(2) will folium artemisiae argyi, Radix Angelicae Sinensis mix after crush, then be added 6 times of quality water decocted, after filter, filtered
Liquid；The filtrate is concentrated, it is 60%, after 4 DEG C of standing 36h, mistake that 95% ethyl alcohol to concentrate alcohol content, which is then added,
It filters out and precipitates, filtrate recycling ethanol is simultaneously concentrated, and obtains Chinese medical concrete；
(3) after mixing kuh-seng, frutus cnidii, 6 times of quality water is added and decoct 1.5h, after filtering, into filtered filter residue
It 6 times of quality water is added carries out second and decoct, then filter, merge filtrate twice, after concentration, in 50 DEG C of baking 6h, then powder
Being broken to partial size is 100 mesh, obtains mixing traditional Chinese medicine powder；
(4) into poly hexamethylene biguanide be added etc. quality water, be stirred to dissolve, then sequentially add step (1) institute
Chinese medicine percolating liquid, step (2) described Chinese medical concrete are stated, stirs evenly, obtains A phase；Borneol, menthol, thymol are mixed,
Then the ethyl alcohol of the quality such as addition, is stirred to dissolve, obtains B phase；4 times of quality are added into step (3) the mixing traditional Chinese medicine powder
Tween 80, stirring make to be uniformly mixed, and obtain C phase；
(5) water of 200 times of quality of carbomer is added into carbomer, standing 6h makes sufficiently to be swollen, and then sequentially adds sweet
Oil, A phase, B phase, adjusting pH with triethanolamine is 5.2, obtains gel-type vehicle, C phase is added in Xiang Suoshu gel-type vehicle, then with
The speed of 1000r/min stirs evenly to get the gynecological gel.
Embodiment 2
The present embodiment provides a kind of gynecological gel, raw material components include:
1 parts by weight of traditional Chinese medicinal components, 0.02 parts by weight of poly hexamethylene biguanide, 0.4 parts by weight of borneol, 0.4 weight of menthol
Part, 5 parts by weight of thymol, 0.5 parts by weight of carbomer, 8 parts by weight of glycerol；
The traditional Chinese medicinal components include safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis, the safflower, cnidium monnieri
Weight ratio between son, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis is 20:25:25:20:15:10:10.
Further, a kind of method preparing the gynecological gel is provided, is included the following steps:
(1) it is crushed after mixing safflower, Cortex Phellodendri, motherwort, 95% ethyl alcohol of 3 times of quality is then added, first impregnated 9 days,
The mixed raw material after dipping is subjected to diacolation with the speed of 5ml/kg/min again, after recycling ethyl alcohol, being concentrated into relative density is
1.10,30h is stood, Chinese medicine percolating liquid is obtained；
(2) will folium artemisiae argyi, Radix Angelicae Sinensis mix after crush, then be added 10 times of quality water decocted, after filter, filtered
Liquid；The filtrate is concentrated, it is 80% that 95% ethyl alcohol to alcohol content, which is then added, after 8 DEG C stand for 24 hours, is filtered to remove
Precipitating, filtrate recycling ethanol are simultaneously concentrated, and obtain Chinese medical concrete；
(3) after mixing kuh-seng, frutus cnidii, 8 times of quality water is added and decoct 2.5h, after filtering, into filtered filter residue
It 8 times of quality water is added carries out second and decoct, then filter, merge filtrate twice, after concentration, in 60 DEG C of baking 4h, then powder
Being broken to partial size is 200 mesh, obtains mixing traditional Chinese medicine powder；
(4) water of 2 times of quality is added into poly hexamethylene biguanide, is stirred to dissolve, then sequentially adds step (1) institute
Chinese medicine percolating liquid, step (2) described Chinese medical concrete are stated, stirs evenly, obtains A phase；Borneol, menthol, thymol are mixed,
Then the ethyl alcohol of 3 times of quality is added, is stirred to dissolve, obtains B phase；6 times of quality are added into step (3) the mixing traditional Chinese medicine powder
Tween 80, stirring make to be uniformly mixed, and obtain C phase；
(5) into carbomer be added 400 times of quality water, stand 8h make sufficiently to be swollen, then sequentially add glycerol, A phase,
B phase, adjusting pH with triethanolamine is 6.7, obtains gel-type vehicle, C phase is added in Xiang Suoshu gel-type vehicle, then with 2000r/min
Speed stir evenly to get the gynecological gel.
Embodiment 3
The present embodiment provides a kind of gynecological gel, raw material components include:
0.8 parts by weight of traditional Chinese medicinal components, 0.018 parts by weight of poly hexamethylene biguanide, 0.2 parts by weight of borneol, 0.2 weight of menthol
Measure part, 3 parts by weight of thymol, 0.3 parts by weight of carbomer, 6 parts by weight of glycerol；
The traditional Chinese medicinal components include safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis, the safflower, cnidium monnieri
Weight ratio between son, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis is 8:15:18:12:8:7:7.
Further, a kind of method preparing the gynecological gel is provided, is included the following steps:
(1) it is crushed after mixing safflower, Cortex Phellodendri, motherwort, 95% ethyl alcohol of 2 times of quality is then added, first impregnated 7 days,
The mixed raw material after dipping is subjected to diacolation with the speed of 3ml/kg/min again, after recycling ethyl alcohol, being concentrated into relative density is
1.10,22h is stood, Chinese medicine percolating liquid is obtained；
(2) will folium artemisiae argyi, Radix Angelicae Sinensis mix after crush, then be added 8 times of quality water decocted, after filter, filtered
Liquid；The filtrate is concentrated, it is 65% that 95% ethyl alcohol to alcohol content, which is then added, after 5 DEG C of standing 30h, is filtered to remove
Precipitating, filtrate recycling ethanol are simultaneously concentrated, and obtain Chinese medical concrete；
(3) after mixing kuh-seng, frutus cnidii, 7 times of quality water is added and decoct 2h, after filtering, add into filtered filter residue
Enter 7 times of quality water and carry out second of decoction, then filters, merge filtrate twice, after concentration, in 60 DEG C of baking 5h, then crush
It is 100 mesh to partial size, obtains mixing traditional Chinese medicine powder；
(4) water of 1.5 times of quality is added into poly hexamethylene biguanide, is stirred to dissolve, then sequentially adds step (1)
The Chinese medicine percolating liquid, step (2) described Chinese medical concrete, stir evenly, obtain A phase；Borneol, menthol, thymol are mixed
It closes, the ethyl alcohol of 2 times of quality is then added, is stirred to dissolve, obtains B phase；5 times are added into step (3) the mixing traditional Chinese medicine powder
Quality Tween 80, stirring make to be uniformly mixed, and obtain C phase；
(5) into carbomer be added 300 times of quality water, stand 7h make sufficiently to be swollen, then sequentially add glycerol, A phase,
B phase, adjusting pH with triethanolamine is 5.8, obtains gel-type vehicle, C phase is added in Xiang Suoshu gel-type vehicle, then with 2000r/min
Speed stir evenly to get the gynecological gel.
Embodiment 4
The present embodiment provides a kind of gynecological gel, raw material components include:
0.8 parts by weight of traditional Chinese medicinal components, 0.018 parts by weight of poly hexamethylene biguanide, 0.2 parts by weight of borneol, 0.2 weight of menthol
Measure part, 3 parts by weight of thymol, 0.3 parts by weight of carbomer, 6 parts by weight of glycerol；
The traditional Chinese medicinal components include safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis, the safflower, cnidium monnieri
Weight ratio between son, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis is 15:22:22:18:12:9:9.
Further, a kind of method preparing the gynecological gel is provided, is included the following steps:
(1) it is crushed after mixing safflower, Cortex Phellodendri, motherwort, 95% ethyl alcohol of 1.5 times of quality is then added, first impregnates 7
It, then the mixed raw material after dipping is subjected to diacolation with the speed of 1ml/kg/min, after recycling ethyl alcohol, being concentrated into relative density is
1.10,26h is stood, Chinese medicine percolating liquid is obtained；
(2) will folium artemisiae argyi, Radix Angelicae Sinensis mix after crush, then be added 9 times of quality water decocted, after filter, filtered
Liquid；The filtrate is concentrated, it is 70% that 95% ethyl alcohol to alcohol content, which is then added, after 4 DEG C of standing 30h, is filtered to remove
Precipitating, filtrate recycling ethanol are simultaneously concentrated, and obtain Chinese medical concrete；
(3) after mixing kuh-seng, frutus cnidii, 7 times of quality water is added and decoct 2h, after filtering, add into filtered filter residue
Enter 7 times of quality water and carry out second of decoction, then filters, merge filtrate twice, after concentration, in 60 DEG C of baking 5h, then crush
It is 100 mesh to partial size, obtains mixing traditional Chinese medicine powder；
(4) water of 2 times of quality is added into poly hexamethylene biguanide, is stirred to dissolve, then sequentially adds step (1) institute
Chinese medicine percolating liquid, step (2) described Chinese medical concrete are stated, stirs evenly, obtains A phase；Borneol, menthol, thymol are mixed,
Then the ethyl alcohol of 2 times of quality is added, is stirred to dissolve, obtains B phase；5 times of quality are added into step (3) the mixing traditional Chinese medicine powder
Tween 80, stirring make to be uniformly mixed, and obtain C phase；
(5) into carbomer be added 300 times of quality water, stand 6h make sufficiently to be swollen, then sequentially add glycerol, A phase,
B phase, adjusting pH with triethanolamine is 6.4, obtains gel-type vehicle, C phase is added in Xiang Suoshu gel-type vehicle, then with 2000r/min
Speed stir evenly to get the gynecological gel.
Embodiment 5
The present embodiment provides a kind of gynecological gel, raw material components include:
0.8 parts by weight of traditional Chinese medicinal components, 0.018 parts by weight of poly hexamethylene biguanide, 0.2 parts by weight of borneol, 0.2 weight of menthol
Measure part, 3 parts by weight of thymol, 0.3 parts by weight of carbomer, 6 parts by weight of glycerol；
The traditional Chinese medicinal components include safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi, Radix Angelicae Sinensis, the safflower, cnidium monnieri
Son, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi, the weight ratio between Radix Angelicae Sinensis are 12:18:20:15:10:8:8.
Further, a kind of method preparing the gynecological gel is provided, is included the following steps:
(1) it is crushed after mixing safflower, Cortex Phellodendri, motherwort, 95% ethyl alcohol of 2 times of quality is then added, first impregnated 7 days,
The mixed raw material after dipping is subjected to diacolation with the speed of 2ml/kg/min again, after recycling ethyl alcohol, being concentrated into relative density is
1.10,28h is stood, Chinese medicine percolating liquid is obtained；
(2) will folium artemisiae argyi, Radix Angelicae Sinensis mix after crush, then be added 7 times of quality water decocted, after filter, filtered
Liquid；The filtrate is concentrated, it is 75% that 95% ethyl alcohol to alcohol content, which is then added, after 4 DEG C of standing 30h, is filtered to remove
Precipitating, filtrate recycling ethanol are simultaneously concentrated, and obtain Chinese medical concrete；
(3) after mixing kuh-seng, frutus cnidii, 7 times of quality water is added and decoct 2h, after filtering, add into filtered filter residue
Enter 7 times of quality water and carry out second of decoction, then filters, merge filtrate twice, after concentration, in 60 DEG C of baking 5h, then crush
It is 100 mesh to partial size, obtains mixing traditional Chinese medicine powder；
(4) water of 2 times of quality is added into poly hexamethylene biguanide, is stirred to dissolve, then sequentially adds step (1) institute
Chinese medicine percolating liquid, step (2) described Chinese medical concrete are stated, stirs evenly, obtains A phase；Borneol, menthol, thymol are mixed,
Then the ethyl alcohol of 2 times of quality is added, is stirred to dissolve, obtains B phase；5 times of quality are added into step (3) the mixing traditional Chinese medicine powder
Tween 80, stirring make to be uniformly mixed, and obtain C phase；
(5) into carbomer be added 300 times of quality water, stand 8h make sufficiently to be swollen, then sequentially add glycerol, A phase,
B phase, adjusting pH with triethanolamine is 5.9, obtains gel-type vehicle, C phase is added in Xiang Suoshu gel-type vehicle, then with 2000r/min
Speed stir evenly to get the gynecological gel.
Comparative example 1
This comparative example provides a kind of gynecological gel, and the difference with embodiment 5 is only that in raw material components without traditional Chinese medicinal components.
Comparative example 2
This comparative example provides a kind of gynecological gel, and the difference with embodiment 5 is only that in raw material components without poly- six methylene
Base biguanides.
Comparative example 3
This comparative example provides a kind of gynecological gel, and the difference with embodiment 5 is only that in raw material components without thymol.
Comparative example 4
This comparative example provides a kind of gynecological gel, and the difference with embodiment 5 is only that traditional Chinese medicinal components in preparation method not
It is grouped extraction, and uses and will be prepared into Chinese medicine percolating liquid after the mixing of all traditional Chinese medicinal components, then mixes system with other ingredients
It is standby to form.Specifically comprise the following steps:
(1) it is crushed after mixing safflower, Cortex Phellodendri, motherwort, folium artemisiae argyi, Radix Angelicae Sinensis, kuh-seng, frutus cnidii, 2 times of quality is then added
95% ethyl alcohol, first impregnate 7 days, then the mixed raw material after dipping is subjected to diacolation with the speed of 2ml/kg/min, recycle ethyl alcohol
Afterwards, being concentrated into relative density is 1.10, stands 28h, obtains Chinese medicine percolating liquid；
(2) into poly hexamethylene biguanide be added 2 times of quality water, be stirred to dissolve, then be added step (1) it is described in
Medicine percolate, stirs evenly, and obtains A phase；Borneol, menthol, thymol are mixed, the ethyl alcohol of 2 times of quality is then added, stirs
Mixing makes to dissolve, and obtains B phase；
(3) into carbomer be added 300 times of quality water, stand 8h make sufficiently to be swollen, then sequentially add glycerol, A phase,
B phase, adjusting pH with triethanolamine is 6.0, obtains gel-type vehicle, and Tween 80 is added in Xiang Suoshu gel-type vehicle, and (additional amount is the same as implementation
Example 5), then stirred evenly with the speed of 2000r/min to get the gynecological gel.
Comparative example 5
This comparative example provides a kind of gynecological gel, and the difference with embodiment 5 is only that traditional Chinese medicinal components in preparation method not
It is grouped extraction, and uses and will be prepared into Chinese medical concrete after the mixing of all traditional Chinese medicinal components, is then mixed with other ingredients
It forms.Specifically comprise the following steps:
(1) it is crushed after mixing safflower, Cortex Phellodendri, motherwort, folium artemisiae argyi, Radix Angelicae Sinensis, kuh-seng, frutus cnidii, 7 times of quality is then added
Water is decocted, after filter, obtain filtrate；The filtrate is concentrated, 95% ethyl alcohol to alcohol content, which is then added, is
75%, after 4 DEG C of standing 30h, it is filtered to remove precipitating, filtrate recycling ethanol is simultaneously concentrated, and obtains Chinese medical concrete；
(2) into poly hexamethylene biguanide be added 2 times of quality water, be stirred to dissolve, then be added step (1) it is described in
Medicine medicinal extract, stirs evenly, and obtains A phase；Borneol, menthol, thymol are mixed, the ethyl alcohol of 2 times of quality, stirring is then added
Make to dissolve, obtains B phase；
(3) into carbomer be added 300 times of quality water, stand 8h make sufficiently to be swollen, then sequentially add glycerol, A phase,
B phase, adjusting pH with triethanolamine is 5.6, obtains gel-type vehicle, and Tween 80 is added in Xiang Suoshu gel-type vehicle, and (additional amount is the same as implementation
Example 5), then stirred evenly with the speed of 2000r/min to get the gynecological gel.
Comparative example 6
This comparative example provides a kind of gynecological gel, and the difference with embodiment 5 is only that traditional Chinese medicinal components in preparation method not
It is grouped extraction, and uses and will be prepared into mixing traditional Chinese medicine powder after the mixing of all traditional Chinese medicinal components, then mixes system with other ingredients
It is standby to form.Specifically comprise the following steps:
(1) will safflower, Cortex Phellodendri, motherwort, folium artemisiae argyi, Radix Angelicae Sinensis, kuh-seng, frutus cnidii mix after, be added 7 times of quality water carry out it is pan-fried
It boils, after filtering, 7 times of quality water is added into filtered filter residue and carry out second of decoction, then filters, merges filtrate twice,
After concentration, in 60 DEG C of baking 5h, being then crushed to partial size is 100 mesh, obtains mixing traditional Chinese medicine powder；
(2) water of 2 times of quality is added into poly hexamethylene biguanide, is stirred to dissolve, obtains A phase；By borneol, peppermint
Brain, thymol mixing, are then added the ethyl alcohol of 2 times of quality, are stirred to dissolve, obtain B phase；Into step (1) described mixing
5 times of quality Tween 80s are added in medicinal powder, stirring makes to be uniformly mixed, and obtains C phase；
(3) into carbomer be added 300 times of quality water, stand 8h make sufficiently to be swollen, then sequentially add glycerol, A phase,
B phase, adjusting pH with triethanolamine is 5.5, obtains gel-type vehicle, C phase is added in Xiang Suoshu gel-type vehicle, then with 2000r/min
Speed stir evenly to get the gynecological gel.
Experimental example
The gynecological gel that above embodiments and comparative example are prepared has carried out experiment inspection in terms of quality, fungistatic effect
It surveys.
One, quality research
1, appearance stability is tested: being taken each test specimen, is placed for 24 hours, then take out in 4041 DEG C of insulating boxs, restores extremely
Room temperature compares with the sample placed at room temperature, observes the variation of quality.It the results are shown in Table 1.
2, poly hexamethylene biguanide content rate of descent is tested: according to GB 15979-2002, " Disposable Sanitary Accessory is defended
Raw standard " and " disinfection technology standard " (2002) 1.4.1.5 (3) test sample in poly hexamethylene biguanide initial content (a0) with
And poly hexamethylene biguanide content (a after 90d is saved under the conditions of temperature is 37340 DEG C, relative humidity >=75%1), then count
The rate of descent (b) of poly hexamethylene biguanide content in sample is calculated, wherein b=(a0-a1)/a0× 100%.It the results are shown in Table 1.
1 quality measurements of table
Two, bacteriostatic test
1, test strain: Escherichia coli (8099) were cultivated for 9 generations, and Candida albicans (ATCC10231) was cultivated for 9 generations, golden yellow
Staphylococcus (ATCC6538) cultivated for 9 generations, was provided by Chinese Culture Collection Center.
2, culture medium: ordinary nutrient agar culture medium, sabouraud's agar, by Beijing road and bridge technology Co., Ltd
It provides,
3, test method: according to GB 15979-2002 " Disposable Sanitary Accessory sanitary standard " appendix C 4 and " disinfection
Technical specification " (2002) 2.1.8 tests.
4, test result: under the conditions of test temperature is 2042 DEG C, each test specimen reads Escherichia coli (8099), white
The average bacteriostasis rate of pearl bacterium (ATCC10231) and staphylococcus aureus (ATCC6538) is shown in Table 2.
2 bacteriostatic test result of table
The result shows that the gynecological gel that preparation method of the present invention obtains is in appearance stability, poly hexamethylene biguanide content
Comparative example is significantly better than that in terms of rate of descent, bacteriostasis rate.
Two, vaginal mucosa irritation is tested
1, tested material: the sample that embodiment 5 is prepared
2, experimental animal: providing Japanese white big ear rabbit 6 by Xi'an Jiaotong University Medical College's Experimental Animal Center, female
Property, weight 2.0-2.5kg, primary animal.
3, it test basis: is tested by " disinfection technology standard " (2002) 2.3.5 method.
4, test method
6 estrus Japan white big ear rabbits are randomly divided into 2 groups, respectively tested material group and control group, and every group 3,
Supine is fixed when test, and tested material group Via vagina injects tested material 2g/ only, and control group gives co-content physiological saline, is moved
Object is lain on the back fixed 4h, comes into full contact with tested material with vagina mucosa, and animal puts back to raising in cage after the test, is put to death afterwards for 24 hours
Phenomena such as animal takes out vagina tissue, visually observes mucosal degeneration, secretion, the congestion of blood vessel, oedema.
5, test result is shown in Table 3.
3 vaginal mucosa irritation of table reaction integral
It is observed that tested material group rabbit vagina mucous membrane form it is normal, without secretion, without it is congested, without swelling, have no that mucous membrane becomes
It sexually revises.It is 0 point that vaginal mucosa irritation, which reacts average integral, anti-according to " disinfection technology standard " (2002) medial vagina mucosal irritation
Grade scale is answered, the present invention should belong to nonirritant to the reaction of rabbit vagina mucosal irritation.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of gynecological gel, which is characterized in that raw material components include: traditional Chinese medicinal components 0.5-1 parts by weight, poly hexamethylene biguanide
0.015-0.02 parts by weight, borneol 0.1-0.4 parts by weight, menthol 0.1-0.4 parts by weight, thymol 2-5 parts by weight, card wave
Nurse 0.2-0.5 parts by weight, glycerol 4-8 parts by weight；
The traditional Chinese medicinal components include safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis, the safflower, frutus cnidii,
Weight ratio between kuh-seng, Cortex Phellodendri, motherwort, folium artemisiae argyi and Radix Angelicae Sinensis is 5-20:10-25:15-25:10-20:5-15:5-10:5-
10。
2. gynecological gel according to claim 1, which is characterized in that the safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, benefit are female
Weight ratio between grass, folium artemisiae argyi and Radix Angelicae Sinensis is 8-15:15-22:18-22:12-18:8-12:7-9:7-9.
3. gynecological gel according to claim 1, which is characterized in that the safflower, frutus cnidii, kuh-seng, Cortex Phellodendri, benefit are female
Weight ratio between grass, folium artemisiae argyi and Radix Angelicae Sinensis is 12:18:20:15:10:8:8.
4. a kind of method for preparing any one of claim 1-3 gynecological gel, which comprises the steps of:
(1) safflower, Cortex Phellodendri, motherwort be crushed after mixing, ethyl alcohol is then added, first impregnates 5-9 days, then by the mixing after dipping
Raw material carries out diacolation with the speed of 0.5-5ml/kg/min, and after recycling ethyl alcohol, concentrated, ageing obtains Chinese medicine percolating liquid；
(2) will folium artemisiae argyi, Radix Angelicae Sinensis mix after crush, then plus water is decocted, after filter, obtain filtrate；By the filtrate
It is concentrated, is then added ethyl alcohol in concentrate, after standing, be filtered to remove precipitating, filtrate recycling ethanol is simultaneously concentrated, and obtains Chinese medicine
Medicinal extract；
(3) by kuh-seng, frutus cnidii mix, then plus water is decocted, after filter；Filtered filtrate is successively carried out dense
Contracting, dry, crushing, obtain mixing traditional Chinese medicine powder；
(4) water is added into poly hexamethylene biguanide, is stirred to dissolve, then sequentially add step (1) Chinese medicine percolating liquid,
Step (2) described Chinese medical concrete, stirs evenly, obtains A phase；Borneol, menthol, thymol are mixed, ethyl alcohol is then added,
It is stirred to dissolve, obtains B phase；Tween 80 is added into step (3) the mixing traditional Chinese medicine powder, stirring makes to be uniformly mixed, and obtains C
Phase；
(5) add water to make sufficiently to be swollen into carbomer, then sequentially add glycerol, A phase, B phase, adjust pH to 5-7, obtain gel base
C phase is added in Xiang Suoshu gel-type vehicle, stirs evenly to get the gynecological gel for matter.
5. the preparation method according to claim 4, which is characterized in that in step (1), the mass concentration of the ethyl alcohol is
The weight ratio of 95wt%, the smashed raw material and ethyl alcohol is 1:1-3.
6. the preparation method according to claim 4, which is characterized in that in step (1), the time of the dipping is 7 days, institute
The speed for stating diacolation is 3ml/kg/min, and it is 1.08-1.10 that relative density is concentrated into described in progress, and the ageing is standing 20-
30h。
7. the preparation method according to claim 4, which is characterized in that in step (2), the smashed raw material and water
Weight ratio is 1:6-10, and it is 60-80% that ethyl alcohol alcohol content into concentrate, which is added, and the mass concentration of the ethyl alcohol is
95wt%, the time of the standing are 24-36h, and the temperature of the standing is 4-8 DEG C.
8. the preparation method according to claim 4, which is characterized in that in step (3), the mixed raw material and water
Weight ratio is 1:6-8；The time of the decoction is 1.5-2.5h；The temperature of the drying is 50-60 DEG C, the time of the drying
For 4-6h；The partial size that is crushed to is 100-200 mesh.
9. the preparation method according to claim 4, which is characterized in that in step (4), the poly hexamethylene biguanide and water
Weight ratio be 1:1-2, the weight ratio of the mixed raw material of the borneol, menthol, thymol and ethyl alcohol is 1:1-3, institute
The weight ratio for stating mixing traditional Chinese medicine powder and Tween 80 is 1:4-6.
10. the preparation method according to claim 4, which is characterized in that in step (5), the weight of the carbomer and water
Than for 1:200-400, pH adjusting agent is triethanolamine, the speed of the stirring is 1000-2000r/min.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613839A (en) * | 2019-10-28 | 2019-12-27 | 田兰 | Chinese medicinal biological preparation for acting on female reproductive system and preparation method thereof |
| CN111000955A (en) * | 2019-12-30 | 2020-04-14 | 重庆宫妙生物科技有限公司 | Firming antibacterial gel and preparation method thereof |
| CN111068016A (en) * | 2020-01-17 | 2020-04-28 | 璧典附 | Lightyellow sophora root private nursing antibacterial gel and preparation method thereof |
| CN111569054A (en) * | 2020-06-09 | 2020-08-25 | 陕西丽仕生物科技有限公司 | Gynecological antibacterial gel and preparation method thereof |
| CN112206308A (en) * | 2020-11-21 | 2021-01-12 | 陕西远志医药生物工程有限公司 | Nourishing and bacteriostatic gel and preparation method thereof |
| CN112569275A (en) * | 2020-12-14 | 2021-03-30 | 欧迪玛(湖北)生物科技有限公司 | Gynecological vagina contracting gel composition and preparation method and application thereof |
| CN113274467A (en) * | 2021-06-04 | 2021-08-20 | 高丽莉 | Gynecological antibacterial gel and preparation method thereof |
| CN113876850A (en) * | 2021-09-24 | 2022-01-04 | 湖南省粉嫩佳人生物科技有限公司 | Method for preparing finished anti-inflammatory gynecological gel product |
| CN113940981A (en) * | 2021-11-23 | 2022-01-18 | 徐州源丰美健康科技发展有限公司 | Gynecological herbal nursing gel |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1188656A (en) * | 1997-01-21 | 1998-07-29 | 何元森 | Health-care knickers containing motherwort and manufacturing method thereof |
| CN103990036A (en) * | 2014-05-29 | 2014-08-20 | 周慧婷 | Traditional Chinese medicine composition for relieving menstrual pain and preparation method and application thereof |
| CN107802825A (en) * | 2017-12-04 | 2018-03-16 | 陕西美芙康生物科技有限公司 | A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa |
-
2019
- 2019-04-29 CN CN201910356256.9A patent/CN109876051A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1188656A (en) * | 1997-01-21 | 1998-07-29 | 何元森 | Health-care knickers containing motherwort and manufacturing method thereof |
| CN103990036A (en) * | 2014-05-29 | 2014-08-20 | 周慧婷 | Traditional Chinese medicine composition for relieving menstrual pain and preparation method and application thereof |
| CN107802825A (en) * | 2017-12-04 | 2018-03-16 | 陕西美芙康生物科技有限公司 | A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613839A (en) * | 2019-10-28 | 2019-12-27 | 田兰 | Chinese medicinal biological preparation for acting on female reproductive system and preparation method thereof |
| CN111000955A (en) * | 2019-12-30 | 2020-04-14 | 重庆宫妙生物科技有限公司 | Firming antibacterial gel and preparation method thereof |
| CN111068016A (en) * | 2020-01-17 | 2020-04-28 | 璧典附 | Lightyellow sophora root private nursing antibacterial gel and preparation method thereof |
| CN111569054A (en) * | 2020-06-09 | 2020-08-25 | 陕西丽仕生物科技有限公司 | Gynecological antibacterial gel and preparation method thereof |
| CN112206308A (en) * | 2020-11-21 | 2021-01-12 | 陕西远志医药生物工程有限公司 | Nourishing and bacteriostatic gel and preparation method thereof |
| CN112569275A (en) * | 2020-12-14 | 2021-03-30 | 欧迪玛(湖北)生物科技有限公司 | Gynecological vagina contracting gel composition and preparation method and application thereof |
| CN113274467A (en) * | 2021-06-04 | 2021-08-20 | 高丽莉 | Gynecological antibacterial gel and preparation method thereof |
| CN113876850A (en) * | 2021-09-24 | 2022-01-04 | 湖南省粉嫩佳人生物科技有限公司 | Method for preparing finished anti-inflammatory gynecological gel product |
| CN113940981A (en) * | 2021-11-23 | 2022-01-18 | 徐州源丰美健康科技发展有限公司 | Gynecological herbal nursing gel |
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Application publication date: 20190614 |