CN101829193B - Medicine composite for treating cervical erosion and preparation method thereof - Google Patents
Medicine composite for treating cervical erosion and preparation method thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000003814 drug Substances 0.000 title claims abstract description 21
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- 239000002131 composite material Substances 0.000 title abstract 6
- 239000000284 extract Substances 0.000 claims abstract description 69
- 244000166124 Eucalyptus globulus Species 0.000 claims abstract description 23
- 235000004692 Eucalyptus globulus Nutrition 0.000 claims abstract description 23
- 241000238675 Periplaneta americana Species 0.000 claims abstract description 22
- 238000002156 mixing Methods 0.000 claims abstract description 10
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine composite for treating cervical erosion and a preparation method thereof. The medicine composite mainly comprises a mixture of active ingredients prepared from periplaneta Americana extract, fructus cnidii, radix sophorae flavescentis and eucalyptus globulus leaf, and the active ingredients are in the following proportion by weight: 1,000 parts of periplaneta Americana extract, 10-1,800 parts of fructus cnidii, 15-1,800 parts of radix sophorae flavescentis and 20-3,000 parts of eucalyptus globulus leaf. The preparation method of the medicine composite for treating cervical erosion comprises the following steps of: extracting the periplaneta Americana extract; mixing and extracting the fructus cnidii, the radix sophorae flavescentis and the eucalyptus globulus leaf; mixing and preparing the medicine composite. In the invention, the medicine composite has simple preparation method, gives full play to the function of the periplaneta Americana extract, effectively improves the curative effect on the cervical erosion, is convenient to use, has tiny toxic and side effects, and is a new medicament worthy of generalization.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of pharmaceutical composition of treating cervical erosion and preparation method thereof.
Background technology
It is documented that periplaneta americana is the maximum insecticide of volume in the Blattidae, originates in South America; Periplaneta americana is the traditional Chinese medicines material, is used as medicine its property plug salty in the mouth with dry and bright adult; Poisonous, acid is arranged, functions such as dissipating blood stasis, removing food stagnancy, detoxifcation, diuretic, detumescence are arranged; Curing mainly infantile malnutrition, tonsillitis, health enclosed mass, carbuncle skin ulcer swells and ache and Scolopendra, venom etc.
In recent years along with science and technology constantly develops, through discovering that for many years the periplaneta americana epidermis contains sclerotin and chitin, elements such as bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium; Muscle hydrolysis 13 seed amino acids; Its alcohol extract has the obvious suppression effect to cancerous cell, and cardiovascular disease is had tangible curative effect.In addition, health storage vitamin B
1, B
2, nicotinic acid and ascorbic acid etc., lymph contain trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc.All contain ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.Clinical main application has: treat infantile malnutrition, control the carbuncle pyogenic infections from tumour or sore, control the Scolopendra wound, control innominate toxic swelling, control the worm venom.But also have periplaneta americana and medical herbs compatibility auxiliary treatment colon cancer.American-cockroach-extract can be controlled hepatitis B, and extract A T-2 preparation can cure mainly primary hepatocarcinoma, cardiovascular disease etc.
Notification number is CN 100525781C; Name is called " American-cockroach-extract, contain pharmaceutical composition of this extract and preparation method thereof " and publication number is CN1943600A; It is two with the American-cockroach-extract relevant patent documentations of applicant in application in 2006 that name is called " pharmaceutical composition and the new purposes thereof that contain periplaneta americana and ethanol extraction thereof "; It discloses the method for preparing and the part medical usage of American-cockroach-extract; In recent years, along with the further research to American-cockroach-extract, American-cockroach-extract has obtained further development in purposes pharmaceutically.
Cervical erosion is the modal a kind of performance of chronic cervicitis, also is the common a kind of disease of married woman.The statistics from the whole nation just have one to get cervical erosion among per three women, and cervical erosion also has confidential relation with cervical cancer.Therefore actively prevent and treat cervical erosion to ensureing that WomanHealth has significant meaning.For treatment cervical erosion, commonly used clinically have five big methods such as pharmacotherapy, isotope therapy, physiotherapy, cryotherapy, cervix uteri excision.Clinical practice shows that said method cuts both ways, and curative effect difference is bigger.And middle-aged women is as the group of people at high risk of cervical erosion, more acceptant pharmacotherapy.Yet existing medicine still is difficult to fully up to expectations for treatment cervical erosion.For this reason, the invention provides a kind of new pharmaceutical composition that is used to treat cervical erosion.
Summary of the invention
The objective of the invention is to: overcome above-mentioned deficiency of the prior art, a kind of pharmaceutical composition and preparation method thereof of treatment cervical erosion of effective raising cure rate is provided.
The object of the invention is realized through following technical scheme: a kind of pharmaceutical composition of treating cervical erosion is provided, it is characterized in that: the main component of said pharmaceutical composition and mass parts thereof are such as shown in down: 1000 parts of American-cockroach-extracts; Fructus Cnidii 10-1800 part; Radix Sophorae Flavescentis 15-1800 part; Eucalyptus globulus Labill leaf 20-3000 part.
The proportioning of one of preferred version of the pharmaceutical composition of above-mentioned treatment cervical erosion is: 1000 parts of American-cockroach-extracts; 800 parts of Fructus Cnidiis; 1200 parts of Radix Sophorae Flavescentiss; 300 parts of Eucalyptus globulus Labill leafs.
Two proportioning of the preferred version of the pharmaceutical composition of above-mentioned treatment cervical erosion is: 1000 parts of American-cockroach-extracts; 1200 parts of Fructus Cnidiis; 800 parts of Radix Sophorae Flavescentiss; 1800 parts of Eucalyptus globulus Labill leafs.
The preparation of drug combination method of above-mentioned treatment cervical erosion may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., with Fructus Cnidii, Radix Sophorae Flavescentis, Eucalyptus globulus Labill leaf decocte with water three times, 2～4 hours for the first time, 1～3 hour for the second time, 1～3 hour for the third time, decocting liquid filtered filtrating merging, sheet frame filters, and is concentrated into an amount of, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, after filtrating is boiled 20～40 minutes, again through the autoclave sterilization postcooling to room temperature, promptly get patent medicine.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
At the autoclave sterilization of above-mentioned steps described in 3. is under 115 ℃～127 ℃ of temperature, pressure are the condition of 0.05Mpa～0.15Mpa, to carry out sterilization, and sterilization time is 25～35 minutes.
In sum; The preparation of drug combination method that is used to treat cervical erosion provided by the present invention is simple, and has given full play to the effect of American-cockroach-extract, has effectively improved the curative effect to cervical erosion; And easy to use, toxic and side effects is little, is a kind of new medicine that is worthy to be popularized.
The specific embodiment
Do further to specify below in conjunction with the embodiment specific embodiments of the invention:
The main component of the pharmaceutical composition of treatment cervical erosion provided by the present invention and mass parts ratio thereof are: 1000 parts of American-cockroach-extracts; Fructus Cnidii 10-1800 part; Radix Sophorae Flavescentis 15-1800 part; Eucalyptus globulus Labill leaf 20-3000 part.
The proportioning of one of preferred version of the pharmaceutical composition of above-mentioned treatment cervical erosion is: 1000 parts of American-cockroach-extracts; 800 parts of Fructus Cnidiis; 1200 parts of Radix Sophorae Flavescentiss; 300 parts of Eucalyptus globulus Labill leafs.
Two proportioning of the preferred version of the pharmaceutical composition of above-mentioned treatment cervical erosion is: 1000 parts of American-cockroach-extracts; 1200 parts of Fructus Cnidiis; 800 parts of Radix Sophorae Flavescentiss; 1800 parts of Eucalyptus globulus Labill leafs.
The preparation of drug combination method of above-mentioned treatment cervical erosion may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., with Fructus Cnidii, Radix Sophorae Flavescentis, Eucalyptus globulus Labill leaf decocte with water three times, 2～4 hours for the first time, 1～3 hour for the second time, 1～3 hour for the third time, decocting liquid filtered filtrating merging, sheet frame filters, and is concentrated into an amount of, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, after filtrating is boiled 20～40 minutes, again through the autoclave sterilization postcooling to room temperature, promptly get patent medicine.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
At the autoclave sterilization of above-mentioned steps described in 3. is under 115 ℃～127 ℃ of temperature, pressure are the condition of 0.05Mpa～0.15Mpa, to carry out sterilization, and sterilization time is 25～35 minutes.
Embodiment 1:
The prescription that is adopted is: 1000 parts of American-cockroach-extracts; 800 parts of Fructus Cnidiis; 1200 parts of Radix Sophorae Flavescentiss; 300 parts of Eucalyptus globulus Labill leafs.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.05 (70 ℃); Adding concentration is the ethanol of 93%w/w, makes that to become to contain the alcohol amount be 45%, 70 ℃ of insulated and stirred 20 minutes; Left standstill 10 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.20 (70 ℃), normal pressure is concentrated into the unguentum of moisture≤25%; According to unguentum: the ratio of purified water: glycerol=1000g: 1000ml: 5ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With Fructus Cnidii, Radix Sophorae Flavescentis, Eucalyptus globulus Labill leaf decocte with water three times, 2 hours for the first time, 1 hour for the second time, 1 hour for the third time, decocting liquid filtered filtrating merging, and sheet frame filters, and is concentrated into an amount of, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, after filtrating was boiled 20 minutes, through 115 ℃, pressure was 0.05Mpa, sterilizes 25 minutes, is chilled to room temperature, promptly gets again.
Embodiment 2:
The prescription that is adopted is: 1000 parts of American-cockroach-extracts; 1000 parts of American-cockroach-extracts; 1200 parts of Fructus Cnidiis; 800 parts of Radix Sophorae Flavescentiss; 1800 parts of Eucalyptus globulus Labill leafs.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 500Kg water, soaks after 2 hours, and temperature is extracted three times about 78 ℃, 9 hours for the first time; For the second time add water 400Kg, extracted 7 hours; Add water 400Kg for the third time, extracted 5 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.25 (90 ℃); Adding concentration is the ethanol of 97%w/w, makes that to become to contain the alcohol amount be 55%, 90 ℃ of insulated and stirred 40 minutes; Left standstill 14 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.25 (90 ℃), normal pressure is concentrated into the unguentum of moisture≤35%; According to unguentum: the ratio of purified water: glycerol=1000g: 1200ml: 6ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With Fructus Cnidii, Radix Sophorae Flavescentis, Eucalyptus globulus Labill leaf decocte with water three times, 4 hours for the first time, 3 hours for the second time, 3 hours for the third time, decocting liquid filtered filtrating merging, and sheet frame filters, and is concentrated into an amount of, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, after filtrating was boiled 40 minutes, through 127 ℃, pressure was 0.15Mpa, sterilizes 35 minutes, is chilled to room temperature, promptly gets again.
Embodiment 3:
The prescription that is adopted is: 1000 parts of American-cockroach-extracts; 1000 parts of Fructus Cnidiis; 1000 parts of Radix Sophorae Flavescentiss; 1000 parts of Eucalyptus globulus Labill leafs.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 400Kg water, soaks after 1 hour, and temperature is extracted three times about 74 ℃, 8 hours for the first time; For the second time add water 300Kg, extracted 6 hours; Add water 300Kg for the third time, extracted 4 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.15 (80 ℃); Adding concentration is the ethanol of 95%w/w, makes that to become to contain the alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes; Left standstill 12 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.25 (80 ℃), normal pressure is concentrated into the unguentum of moisture≤30%; According to unguentum: the ratio of purified water: glycerol=1000g: 800ml: 4ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With Fructus Cnidii, Radix Sophorae Flavescentis, Eucalyptus globulus Labill leaf decocte with water three times, 3 hours for the first time, 2 hours for the second time, 2 hours for the third time, decocting liquid filtered filtrating merging, and sheet frame filters, and is concentrated into an amount of, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, after filtrating was boiled 35 minutes, through 121 ℃, pressure was 0.1Mpa, sterilizes 30 minutes, is chilled to room temperature, promptly gets again.
Embodiment 4:
The prescription that is adopted is: 1000 parts of American-cockroach-extracts; 600 parts of Fructus Cnidiis; 400 parts of Radix Sophorae Flavescentiss; 2000 parts of Eucalyptus globulus Labill leafs.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 380Kg water, soaks after 0.8 hour, and temperature is extracted three times about 74 ℃, 7.5 hours for the first time; For the second time add water 280Kg, extracted 5 hours; Add water 280Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.2 (80 ℃); Adding concentration is the ethanol of 95%w/w, makes that to become to contain the alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes; Left standstill 11 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.20 (80 ℃), normal pressure is concentrated into the unguentum of moisture≤30%; According to unguentum: the ratio of purified water: glycerol=1000g: 1100ml: 6ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With Fructus Cnidii, Radix Sophorae Flavescentis, Eucalyptus globulus Labill leaf decocte with water three times, 2 hours for the first time, 2 hours for the second time, 2 hours for the third time, decocting liquid filtered filtrating merging, and sheet frame filters, and is concentrated into an amount of, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, after filtrating was boiled 30 minutes, through 121 ℃, pressure was 0.1Mpa, sterilizes 30 minutes, is chilled to room temperature, promptly gets again.
The pharmaceutical composition of treatment cervical erosion provided by the present invention can be processed various ways such as tablet, suppository, capsule, is beneficial to satisfy different patients' medication custom.
The clinical testing data of cervical erosion cure rate:
One, patient's classified data:
Patients of cervical ruin 100 examples meet diagnostic criteria.Be divided into treatment group and matched group at random, 50 examples are organized in treatment, 16～40 years old age; Matched group 50 examples, 16～40 years old age.The two groups of patient ages and the course of disease are through statistical procedures, and difference does not have the significance meaning, has comparability.
Two, Therapeutic Method:
The treatment group: get prepared suppository according to the present invention, in vagina administration, one time one, once-a-day.
Matched group: FUYANLING, in vagina administration, once two, once-a-day.
Three, curative effect comparative result:
Table 1 is depicted as two groups of curative effects relatively, and wherein 50 examples are organized in treatment, cure 48 examples, and cure rate is 96.00%, and total effective rate is 100%; Matched group 50 examples are cured 36 examples, and cure rate is 72.00%, and total effective rate is 92.00%.Table 2 is depicted as two groups of 7 days curative effects relatively, treats in 7 days, and treatment group cure rate is 82.00%, and the matched group cure rate is 64.00%.This shows that treatment group curative effect obviously is superior to matched group.(n number of delegates in table 1 and the table 2)
Table 1
Table 2
| Group | n | 7 days healing patient numbers | 7 days cure rates (%) |
| The treatment group | 50 | 42 | ?82.00 |
| Matched group | 50 | 32 | ?64.00 |
Four, conclusion (of pressure testing):
Cervical erosion is clinical common gynaecopathia, mostly occurs in married woman crowd, and the characteristics of outbreak are repeatedly arranged.The generation of cervical erosion is relevant with multiple factor, and common have infection, immunity or the like.FUYANLING is a kind of medicine that is usually used in the cervical erosion treatment, and certain curative effect is arranged.Periplaneta americana is a kind of insecticide, is commonly called as Blatta seu periplaneta, and body contains the various active composition; Its extract main component is polyalcohols and peptide class active substance, confirms to have promotion epithelial cell, granulation tissue growth through pharmacological research, promotes wound repair; The effect of enhance immunity; But do not have antibacterial action, the medicine that American-cockroach-extract and Fructus Bruceae, Rhizoma Acori Graminei and Folium Artemisiae Argyi are processed not only can infection, can promote the cervical erosion tissue repair simultaneously; Improve the cervical erosion ulcer healing rate, shorten the cervical erosion healing time.Comparing data shows, the curative effect that this medicine is used to treat cervical erosion obviously is superior to medicine FUYANLING commonly used.
Though done to describe in detail in conjunction with the specific embodiment specific embodiments of the invention, should not be construed as is to qualification of the present invention.In the protection domain that claims limited, various modifications that those skilled in the art can make without creative work or distortion still belong to the protection domain of this patent.
Claims (4)
1. pharmaceutical composition of treating cervical erosion is characterized in that: the crude drug of said pharmaceutical composition and mass parts thereof are such as shown in down:
1000 parts of American-cockroach-extracts;
800 parts of Fructus Cnidiis;
1200 parts of Radix Sophorae Flavescentiss;
300 parts of Eucalyptus globulus Labill leafs;
The method for preparing of aforementioned pharmaceutical compositions may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., with Fructus Cnidii, Radix Sophorae Flavescentis, Eucalyptus globulus Labill leaf decocte with water three times, 2～4 hours for the first time, 1～3 hour for the second time, 1～3 hour for the third time, decocting liquid filtered filtrating merging, sheet frame filters, and is concentrated into an amount of, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, after filtrating is boiled 20～40 minutes, again through the autoclave sterilization postcooling to room temperature, promptly get patent medicine.
2. pharmaceutical composition of treating cervical erosion is characterized in that: the crude drug of said pharmaceutical composition and mass parts thereof are such as shown in down:
1000 parts of American-cockroach-extracts;
1200 parts of Fructus Cnidiis;
800 parts of Radix Sophorae Flavescentiss;
1800 parts of Eucalyptus globulus Labill leafs;
The method for preparing of aforementioned pharmaceutical compositions may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., with Fructus Cnidii, Radix Sophorae Flavescentis, Eucalyptus globulus Labill leaf decocte with water three times, 2～4 hours for the first time, 1～3 hour for the second time, 1～3 hour for the third time, decocting liquid filtered filtrating merging, sheet frame filters, and is concentrated into an amount of, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, after filtrating is boiled 20～40 minutes, again through the autoclave sterilization postcooling to room temperature, promptly get patent medicine.
3. according to the pharmaceutical composition of claim 1 or 2 said treatment cervical erosion, it is characterized in that: amount of water is 4 times of amounts among the said step b, and soak time is 1 hour, and soaking temperature is 74 ℃.
4. the pharmaceutical composition of treatment cervical erosion according to claim 1 and 2; It is characterized in that: said step 3. in autoclave sterilization be under 115 ℃～127 ℃ of temperature, pressure are the condition of 0.05Mpa～0.15Mpa, to carry out sterilization, sterilization time is 25～35 minutes.
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Citations (3)
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|---|---|---|---|---|
| CN1135895A (en) * | 1995-05-18 | 1996-11-20 | 杨辉 | Medicine for treating female genital tract diseases and its use |
| CN1351876A (en) * | 2000-11-14 | 2002-06-05 | 深圳市中药总厂 | Chinese medicine external use lotion for treating skin diseases and its preparing method |
| CN1939345A (en) * | 2006-09-30 | 2007-04-04 | 耿福能 | American falx extract, medicinal composition containing it and its making method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1135895A (en) * | 1995-05-18 | 1996-11-20 | 杨辉 | Medicine for treating female genital tract diseases and its use |
| CN1351876A (en) * | 2000-11-14 | 2002-06-05 | 深圳市中药总厂 | Chinese medicine external use lotion for treating skin diseases and its preparing method |
| CN1939345A (en) * | 2006-09-30 | 2007-04-04 | 耿福能 | American falx extract, medicinal composition containing it and its making method |
Non-Patent Citations (1)
| Title |
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| 张慧等.复方双唑泰栓治疗多种类型阴道炎效果观察.《邯郸医学高等专科学校学报》.2005,第18卷(第2期), * |
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Effective date of registration: 20200824 Address after: NO.115, section 3, Airport Road, Xichang City, Liangshan Yi Autonomous Prefecture, Sichuan Province Patentee after: SICHUAN GOODDOCTOR PANXI PHARMACEUTICAL Co.,Ltd. Address before: 15, building 88, building B, four Wei building, No. 610031 Camp Road, Sichuan, Chengdu Patentee before: Geng Funeng |
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