CN101829177B - Medicine composition for postoperative wound restoration and preparation method thereof - Google Patents
Medicine composition for postoperative wound restoration and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for postoperative wound restoration, which is mainly prepared from an active component mixture comprising the following components in parts by weight: 4-10 parts of American cockroach extract, 4-10 parts of earthworm and 2-5 parts of safflower. The preparation method of the medicine composition for postoperative wound restoration comprises the following steps of: extracting the American cockroach extract; extracting active components of the earthworm; and adding safflower powder to be mixed to prepare the medicine composition. The medicine composition for postoperative wound restoration has simple preparation method, sufficiently exerts the action of the American cockroach extract, effectively increases the curative effect on the postoperative wound restoration, is convenient to use, has short healing time and low toxic and side effects, and is a novel drug which is worth to popularize.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of pharmaceutical composition that is used for the postoperative wound surface reparation and preparation method thereof.
Background technology
It is documented that periplaneta americana is the maximum insecticide of volume in the Blattidae, originates in South America; Periplaneta americana is the traditional Chinese medicines material, is used as medicine its property plug salty in the mouth with dry and bright adult; Poisonous, acid is arranged, functions such as dissipating blood stasis, removing food stagnancy, detoxifcation, diuretic, detumescence are arranged; Curing mainly infantile malnutrition, tonsillitis, health enclosed mass, carbuncle skin ulcer swells and ache and Scolopendra, venom etc.
In recent years along with science and technology constantly develops, through discovering that for many years the periplaneta americana epidermis contains sclerotin and chitin, elements such as bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium; Muscle hydrolysis 13 seed amino acids; Its alcohol extract has the obvious suppression effect to cancerous cell, and cardiovascular disease is had tangible curative effect.In addition, health storage vitamin B
1, B
2, nicotinic acid and ascorbic acid etc., lymph contain trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc.All contain ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.Clinical main application has: treat infantile malnutrition, control the carbuncle pyogenic infections from tumour or sore, control the Scolopendra wound, control innominate toxic swelling, control the worm venom.But also have periplaneta americana and medical herbs compatibility auxiliary treatment colon cancer.American-cockroach-extract can be controlled hepatitis B, and extract A T-2 preparation can cure mainly primary hepatocarcinoma, cardiovascular disease etc.
Notification number is CN 100525781C; Name is called " American-cockroach-extract, contain pharmaceutical composition of this extract and preparation method thereof " and publication number is CN1943600A; It is two with the American-cockroach-extract relevant patent documentations of applicant in application in 2006 that name is called " pharmaceutical composition and the new purposes thereof that contain periplaneta americana and ethanol extraction thereof "; It discloses the method for preparing and the part medical usage of American-cockroach-extract; In recent years, along with the further research to American-cockroach-extract, American-cockroach-extract has obtained further development in purposes pharmaceutically.
In sum, the reparation that is used for postoperative wound surface of existing medicine still has a lot of unsatisfactory parts.For this reason, the invention provides a kind of new pharmaceutical composition that postoperative wound surface is repaired that is used for.
Summary of the invention
The objective of the invention is to: overcome above-mentioned deficiency of the prior art, pharmaceutical composition that is used for the postoperative wound surface reparation of a kind of effective raising cure rate and preparation method thereof is provided.
The object of the invention is realized through following technical scheme: a kind of pharmaceutical composition that postoperative wound surface is repaired that is used for is provided, it is characterized in that: the main component of said pharmaceutical composition and mass parts thereof are such as shown in down: 4～10 parts of American-cockroach-extracts; 4～10 parts of Pheretimas; 2～5 parts on Flos Carthami.
The proportioning of one of preferred version of the above-mentioned pharmaceutical composition that is used for the postoperative wound surface reparation is: 8 parts of American-cockroach-extracts; 6 parts of Pheretimas; 4 parts on Flos Carthami.
Two proportioning of the preferred version of the above-mentioned pharmaceutical composition that is used for the postoperative wound surface reparation is: 6 parts of American-cockroach-extracts; 5 parts of Pheretimas; 3 parts on Flos Carthami.
The above-mentioned preparation of drug combination method that is used for the postoperative wound surface reparation may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., with exsiccant Pheretima coarse crushing, add 4～8 times of water gagings, temperature is extracted three times at 70～90 ℃, 6～10 hours for the first time; For the second time add 2～4 times of water gagings, extracted 5～7 hours; Add 2～4 times of water gagings for the third time, extracted 3～5 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.10～1.20 (80 ℃), add 92～98% ethanol; Make that to become to contain alcohol amount be 45～55%, 75～85 ℃ of insulated and stirred 25～35 minutes, left standstill 11～13 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 25～35 minutes, be chilled to room temperature, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, add Flos Carthami fine powder mixing after, again through the autoclave sterilization postcooling to room temperature, promptly get patent medicine.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
At the autoclave sterilization of above-mentioned steps described in 3. is under 115 ℃～127 ℃ of temperature, pressure are the condition of 0.05Mpa～0.15Mpa, to carry out sterilization, and sterilization time is 25～35 minutes.
In sum; It is provided by the present invention that to be used for the preparation of drug combination method that postoperative wound surface repairs simple; And given full play to the effect of American-cockroach-extract; Effectively improved the curative effect that postoperative wound surface is repaired, and easy to use, wound healing is fast, toxic and side effects is little, is a kind of new medicine that is worthy to be popularized.
The specific embodiment
Do further to specify below in conjunction with the embodiment specific embodiments of the invention:
Main component and the mass parts ratio thereof that is used for the pharmaceutical composition of postoperative wound surface reparation provided by the present invention is: 4～10 parts of American-cockroach-extracts; 4～10 parts of Pheretimas; 2～5 parts on Flos Carthami.
The proportioning of one of preferred version of the above-mentioned pharmaceutical composition that is used for the postoperative wound surface reparation is: 8 parts of American-cockroach-extracts; 6 parts of Pheretimas; 4 parts on Flos Carthami.
Two proportioning of the preferred version of the above-mentioned pharmaceutical composition that is used for the postoperative wound surface reparation is: 6 parts of American-cockroach-extracts; 5 parts of Pheretimas; 3 parts on Flos Carthami.
The above-mentioned preparation of drug combination method that is used for the postoperative wound surface reparation may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., with exsiccant Pheretima coarse crushing, add 4～8 times of water gagings, temperature is extracted three times at 70～90 ℃, 6～10 hours for the first time; For the second time add 2～4 times of water gagings, extracted 5～7 hours; Add 2～4 times of water gagings for the third time, extracted 3～5 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.10～1.20 (80 ℃), add 92～98% ethanol; Make that to become to contain alcohol amount be 45～55%, 75～85 ℃ of insulated and stirred 25～35 minutes, left standstill 11～13 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 25～35 minutes, be chilled to room temperature, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, add Flos Carthami fine powder mixing after, again through the autoclave sterilization postcooling to room temperature, promptly get patent medicine.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
At the autoclave sterilization of above-mentioned steps described in 3. is under 115 ℃～127 ℃ of temperature, pressure are the condition of 0.05Mpa～0.15Mpa, to carry out sterilization, and sterilization time is 25～35 minutes.
Embodiment 1:
The prescription that is adopted is: 8 parts of American-cockroach-extracts; 6 parts of Pheretimas; 4 parts on Flos Carthami.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.05 (70 ℃); Adding concentration is the ethanol of 93%w/w, makes that to become to contain the alcohol amount be 45%, 70 ℃ of insulated and stirred 20 minutes; Left standstill 10 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.20 (70 ℃), normal pressure is concentrated into the unguentum of moisture≤25%; According to unguentum: the ratio of purified water: glycerol=1000g: 800ml: 4ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With exsiccant Pheretima coarse crushing, add 4 times of water gagings, temperature is extracted three times at 70 ℃, 6 hours for the first time; For the second time add 2 times of water gagings, extracted 5 hours; Add 2 times of water gagings for the third time, extracted 3 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.10 (80 ℃), add 92% ethanol; Make that to become to contain alcohol amount be 45%, 75 ℃ of insulated and stirred 25 minutes, left standstill 11 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 25 minutes, be chilled to room temperature, subsequent use; Prepared two kinds of extracts mixing is stirred, and through plate-and-frame filtration, behind the adding Flos Carthami fine powder mixing, through 115 ℃, pressure is 0.05Mpa, sterilizes 25 minutes, is chilled to room temperature, promptly gets patent medicine again.
Embodiment 2:
The prescription that is adopted is: 6 parts of American-cockroach-extracts; 5 parts of Pheretimas; 3 parts on Flos Carthami.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 500Kg water, soaks after 2 hours, and temperature is extracted three times about 78 ℃, 9 hours for the first time; For the second time add water 400Kg, extracted 7 hours; Add water 400Kg for the third time, extracted 5 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.25 (90 ℃); Adding concentration is the ethanol of 97%w/w, makes that to become to contain the alcohol amount be 55%, 90 ℃ of insulated and stirred 40 minutes; Left standstill 14 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.25 (90 ℃), normal pressure is concentrated into the unguentum of moisture≤35%; According to unguentum: the ratio of purified water: glycerol=1000g: 1200ml: 6ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With exsiccant Pheretima coarse crushing, add 8 times of water gagings, temperature is extracted three times at 90 ℃, 10 hours for the first time; For the second time add 4 times of water gagings, extracted 7 hours; Add 4 times of water gagings for the third time, extracted 5 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.20 (80 ℃), add 98% ethanol; Make that to become to contain alcohol amount be 55%, 85 ℃ of insulated and stirred 35 minutes, left standstill 13 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.25 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 35 minutes, be chilled to room temperature, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, behind the adding Flos Carthami fine powder mixing, through 127 ℃, pressure is 0.15Mpa, sterilizes 35 minutes, is chilled to room temperature, promptly gets patent medicine again.
Embodiment 3:
The prescription that is adopted is: 4 parts of American-cockroach-extracts; 10 parts of Pheretimas; 2 parts on Flos Carthami.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 400Kg water, soaks after 1 hour, and temperature is extracted three times about 74 ℃, 8 hours for the first time; For the second time add water 300Kg, extracted 6 hours; Add water 300Kg for the third time, extracted 4 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.15 (80 ℃); Adding concentration is the ethanol of 95%w/w, makes that to become to contain the alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes; Left standstill 12 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.25 (80 ℃), normal pressure is concentrated into the unguentum of moisture≤30%; According to unguentum: the ratio of purified water: glycerol=1000g: 1000ml: 5ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With exsiccant Pheretima coarse crushing, add 6 times of water gagings, temperature is extracted three times at 80 ℃, 8 hours for the first time; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.20 (80 ℃), add 96% ethanol; Make that to become to contain alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes, left standstill 12 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 30 minutes, be chilled to room temperature, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, behind the adding Flos Carthami fine powder mixing, through 121 ℃, pressure is 0.1Mpa, sterilizes 30 minutes, is chilled to room temperature, promptly gets patent medicine again.
Embodiment 4:
The prescription that is adopted is: 10 parts of American-cockroach-extracts; 4 parts of Pheretimas; 5 parts on Flos Carthami.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 380Kg water, soaks after 0.8 hour, and temperature is extracted three times about 74 ℃, 7.5 hours for the first time; For the second time add water 280Kg, extracted 5 hours; Add water 280Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.2 (80 ℃); Adding concentration is the ethanol of 95%w/w, makes that to become to contain the alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes; Left standstill 11 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.20 (80 ℃), normal pressure is concentrated into the unguentum of moisture≤30%; According to unguentum: the ratio of purified water: glycerol=1000g: 1100ml: 6ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With exsiccant Pheretima coarse crushing, add 5 times of water gagings, temperature is extracted three times at 90 ℃, 9 hours for the first time; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.15 (80 ℃), add 95% ethanol; Make that to become to contain alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes, left standstill 12 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.21 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 32 minutes, be chilled to room temperature, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, behind the adding Flos Carthami fine powder mixing, through 121 ℃, pressure is 0.1Mpa, sterilizes 30 minutes, is chilled to room temperature, promptly gets patent medicine again.
The pharmaceutical composition that is used for the postoperative wound surface reparation provided by the present invention can be processed various ways such as unguentum, tablet, suppository, capsule, is beneficial to satisfy different patients' medication custom.
The clinical testing data of the cure rate that postoperative wound surface is repaired:
One, patient's classified data:
Patient's 100 examples of underwent operative treatment meet diagnostic criteria.Be divided into treatment group and matched group at random, 50 examples are organized in treatment, male's 26 examples, women's 24 examples, 16～40 years old age; Matched group 50 examples, male's 26 examples, women's 24 examples, 16～40 years old age.Two groups of patient ages, sex and courses of disease are through statistical procedures, and difference does not have the significance meaning, has comparability.
Two, Therapeutic Method:
Treatment group: get unguentum, external application, twice on the one according to drug prepared of the present invention.
Matched group: take common drug Asiaticoside ointment, external application, twice on the one in the postoperative wound repair.
Three, curative effect comparative result:
Table 1 is depicted as two groups of curative effects relatively, and wherein 50 examples are organized in treatment, cure 46 examples, and cure rate is 92.00%, and total effective rate is 100%; Matched group 50 examples are cured 36 examples, and cure rate is 72.00%, and total effective rate is 96.00%.Table 2 is depicted as two groups of 7 days curative effects relatively, treats in 7 days, and treatment group cure rate is 64.00%, and the matched group cure rate is 48.00%.This shows that treatment group curative effect obviously is superior to matched group.(n number of delegates in table 1 and the table 2)
Table 1
Table 2
| Group | n | 7 days healing patient numbers | 7 days cure rates (%) |
| The treatment group | 50 | 32 | 64.00 |
| Matched group | 50 | 24 | 48.00 |
Four, conclusion (of pressure testing):
Asiaticoside ointment is to be usually used in a kind of medicine that postoperative wound surface is repaired, and certain curative effect is arranged.Periplaneta americana is a kind of insecticide, is commonly called as Blatta seu periplaneta, and body contains the various active composition; Its extract main component is polyalcohols and peptide class active substance, confirms to have promotion epithelial cell, granulation tissue growth through pharmacological research, promotes wound repair; The effect of enhance immunity, but do not have antibacterial action, the medicine that American-cockroach-extract and Pheretima, Flos Carthami are processed not only can infection; Simultaneously can promote the quick rehabilitation of postoperative wound surface, improve the healing postoperative wound surface rate, shorten the postoperative wound surface healing time.Comparing data shows that the curative effect that this medicine is used for the postoperative wound surface reparation obviously is superior to medicine Asiaticoside ointment commonly used.
Though done to describe in detail in conjunction with the specific embodiment specific embodiments of the invention, should not be construed as is to qualification of the present invention.In the protection domain that claims limited, various modifications that those skilled in the art can make without creative work or distortion still belong to the protection domain of this patent.
Claims (5)
1. one kind is used for the preparation of drug combination method that postoperative wound surface is repaired, and it is characterized in that: each composition of said pharmaceutical composition and mass parts thereof are such as shown in down: 4～10 parts of American-cockroach-extracts, 4～10 parts of Pheretimas, 2～5 parts on Flos Carthami; Its preparation method may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., with exsiccant Pheretima coarse crushing, add 4～8 times of water gagings, temperature is extracted three times at 70～90 ℃, 6～10 hours for the first time; For the second time add 2～4 times of water gagings, extracted 5～7 hours; Add 2～4 times of water gagings for the third time, extracted 3～5 hours; Merge three times extracting solution, filter, relative density was 1.10～1.20 o'clock when filtrating was concentrated into 80 ℃, added 92%～98% ethanol; Make that to become to contain alcohol amount be 45%～55%, 75～85 ℃ of insulated and stirred 25～35 minutes, left standstill 11～13 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, relative density is 1.20～1.25 when being evaporated to 80 ℃, normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 25～35 minutes, be chilled to room temperature, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, add Flos Carthami fine powder mixing after, again through the autoclave sterilization postcooling to room temperature, promptly get patent medicine.
2. according to claim 1ly be used for the preparation of drug combination method that postoperative wound surface is repaired, it is characterized in that: each composition of said pharmaceutical composition and mass parts thereof are such as shown in down:
8 parts of American-cockroach-extracts;
6 parts of Pheretimas;
4 parts on Flos Carthami.
3. according to claim 1ly be used for the preparation of drug combination method that postoperative wound surface is repaired, it is characterized in that: each composition of said pharmaceutical composition and mass parts thereof are such as shown in down:
6 parts of American-cockroach-extracts;
5 parts of Pheretimas;
3 parts on Flos Carthami.
4. according to claim 1, the 2 or 3 described preparation of drug combination methods that are used for the postoperative wound surface reparation, it is characterized in that: amount of water is 4 times of amounts among the said step b, and soak time is 1 hour, and soaking temperature is 74 ℃.
5. according to claim 1, the 2 or 3 described preparation of drug combination methods that are used for the postoperative wound surface reparation; It is characterized in that: said step 3. in autoclave sterilization be under 115 ℃～127 ℃ of temperature, pressure are the condition of 0.05Mpa～0.15Mpa, to carry out sterilization, sterilization time is 25～35 minutes.
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| CN100525781C (en) * | 2006-09-30 | 2009-08-12 | 耿福能 | American falx extract, medicinal composition containing it and its making method |
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Application publication date: 20100915 Assignee: Sichuan Good Doctor Panxi Pharmaceutical Co., Ltd. Assignor: Geng Funeng Contract record no.: 2013510000088 Denomination of invention: Medicine composition for postoperative wound restoration and preparation method thereof Granted publication date: 20120125 License type: Exclusive License Record date: 20130905 |
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