CN101829220B - Periplaneta Americana pharmaceutical composition for treating ulcerative colitis and preparation method thereof - Google Patents
Periplaneta Americana pharmaceutical composition for treating ulcerative colitis and preparation method thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 11
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- 239000000284 extract Substances 0.000 claims description 59
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- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a periplaneta Americana pharmaceutical composition for treating ulcerative colitis (short for UC), mainly comprising mixtures of effective components prepared from the following components in parts by weight: 6 parts of periplaneta Americana extractive, 4 parts of golden cypress, 12 parts of fructus forsythiae, 8 parts of honeysuckle and 13 parts of dandelion. The method for preparing the periplaneta Americana pharmaceutical composition for treating ulcerative colitis comprises the following steps of preparing the periplaneta Americana extractive, weighing, decocting, and mixing the effective components to prepare the medicine composition. The preparation method is simple, gives full play to the periplaneta Americana extractive and effectively improves the curative effect of the ulcerative colitis.
Description
Technical field
The present invention relates to medical technical field, specifically relate to a kind of American cockroach medicament composition for the treatment of ulcerative colitis and preparation method thereof.
Background technology
It is documented, periplaneta americana is the insecticide of volume maximum in Blattidae, originates in South America, periplaneta americana is traditional Chinese crude drug, with dry and bright adult, is used as medicine, and its property plug salty in the mouth, poisonous, acid is arranged, the functions such as dissipating blood stasis, removing food stagnancy, removing toxic substances, diuretic, detumescence are arranged; Curing mainly infantile malnutrition, tonsillitis, health enclosed mass, carbuncle skin ulcer swells and ache and Scolopendra, venom etc.
Along with science and technology constantly develops, after years of research and found that in recent years, the periplaneta americana epidermis contains sclerotin and chitin, the elements such as bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium; Muscle is hydrolyzed 13 seed amino acids; Its alcohol extract has obvious inhibitory action to cancerous cell, and cardiovascular disease is had to obvious curative effect.In addition, health storage vitamin B
1, B
2, nicotinic acid and ascorbic acid etc., lymph is containing trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc.All containing ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.Clinical main application has: treat infantile malnutrition, control the carbuncle pyogenic infections from tumour or sore, control the Scolopendra wound, control innominate toxic swelling, control the worm venom.But also have periplaneta americana and medical herbs compatibility auxiliary treatment colon cancer.American-cockroach-extract can be controlled hepatitis B, and extract A T-2 preparation can cure mainly primary hepatocarcinoma, cardiovascular disease etc.
Notification number is CN100525781C, name is called " American-cockroach-extract, containing pharmaceutical composition of this extract and preparation method thereof " and publication number be CN1943600A, it is that the applicant is in two patent documentations relevant with American-cockroach-extract of application in 2006 that name is called " pharmaceutical composition that contains periplaneta americana and ethanol extraction thereof and new purposes thereof ", it discloses preparation method and the part medical usage of American-cockroach-extract, in recent years, along with the further research to American-cockroach-extract, American-cockroach-extract has obtained further development in purposes pharmaceutically.
Cortex Phellodendri, for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Salt Flos Lonicerae nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency.
Fructus Forsythiae, heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Flos Lonicerae, heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quench one's thirst, the carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of wine Flos Lonicerae is burning hot.For conjunctival congestion, aphtha.Rhizoma Zingiberis Recens Flos Lonicerae clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually damp and hot middle resistance, feeling of fullness vomiting for cold and heat.Cornel Flos Lonicerae soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, the vomiting acid regurgitation.
Herba Taraxaci, purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.The wine Herba Taraxaci is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For the conjunctival congestion pharyngeal swelling, gingivitis.Ripe Herba Taraxaci rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.The hemostasis of dandelion charcoal cooling blood and removing stasis.For heat in blood, stasis of blood bleeder is arranged.
Yet Clinical results show above-mentioned medical material to treatment ulcerative colitis effect not good enough or inefficacy.
Summary of the invention
The object of the invention is to overcome above-mentioned technical deficiency, a kind of American cockroach medicament composition and preparation method thereof for the treatment of ulcerative colitis of effective raising cure rate is provided.
Purpose of the present invention is achieved through the following technical solutions: a kind of American cockroach medicament composition for the treatment of ulcerative colitis, described pharmaceutical composition is mainly to mix by American-cockroach-extract, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci the effective ingredient compositions of mixtures made, by weight, its proportioning is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2～10: 3～12: 6～15: 6～15: 9～15.Optimum ratio is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=6: 4: 12: 8: 13.
Described pharmaceutical composition also comprises purified water and glycerol, and with the effective ingredient mixture of 1000g weighing scale, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800～1200ml: 4～6ml.The proportioning of preferred version is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
The preparation method of the American cockroach medicament composition for the treatment of ulcerative colitis comprises the following steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: dry periplaneta americana is pulverized, made the periplaneta americana coarse powder, standby;
B, immersion: add the water of 3～5 times of amounts according to the coarse powder of every 100kg, soak under the temperature conditions of 70～78 ℃ and make the coarse powder mixed liquor in 0.5～2 hour, standby; Wherein, preferred version is: the amount that adds water is 4 times of amounts, and soak time is 1 hour, and soaking temperature is 74 ℃;
C, three extractions: the coarse powder mixed liquor adopts the method decocted to carry out three times and extracts, and when the coarse powder mixed liquor is extracted for the first time, extraction time is 7～9 hours; Then after the water that adds remaining 2～4 times of amounts of liquid in the remaining liquid after extracting for the first time, extract for the second time, extraction time is 5～7 hours; More than adding in the most backward remaining liquid after extracting for the second time, after the water of 2～4 times of amounts of liquid, extract for the third time, extraction time is 3～5 hours, makes respectively the extracting solution of three times, standby;
D, filtration for the first time: the extracting solution of three times are merged and mix, then filter and make one-level filtrate, standby;
E, concentrated for the first time: the one-level concentrated solution that when one-level filtrate is concentrated into to 70～90 ℃, relative density is 1.05～1.25, standby;
F, alcoholization are processed: add gradually the ethanol that concentration is 93～97%w/w in the one-level concentrated solution, and fully stir, make it contain the alcohol amount and reach till 45～55%, be incubated 20～40 minutes under the temperature conditions of 70～90 ℃, then standing 10～14 hours, make solution of alcoholized, standby;
G, filtration for the second time: solution of alcoholized is discarded to the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate, standby;
H, concentrated for the second time: after secondary filtrate is carried out to the ethanol recycling, the secondary concentrated solution that while being concentrated into 70～90 ℃, relative density is 1.15～1.30, standby;
I, unguentum preparation: the secondary concentrated solution is concentrated under condition of normal pressure to the unguentum of moisture≤25～35%, obtains American-cockroach-extract-containing, standby;
2., weighing: by American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2～10: 3～12: 6～15: 6～15: 9～15 weight part ratio carries out weighing, standby;
3., decoct: Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add for the first time 5～7 times of amounts of water, decoct 2～4 hours, rear 3～5 times of amounts of water that at every turn add for twice, decoct 1～3 hour, and the decocting liquid after then three times being decocted filters, filtrate merges, filter through sheet frame again, be concentrated into 1000ml, make the decoction mixed liquor standby;
4., the mixing of effective ingredient: by American-cockroach-extract with decoct mixed liquor and mixed merging, stir, make the effective ingredient mixture, standby;
5., patent medicine: according to the effective ingredient mixture: the weight ratio of purified water: glycerol=1000g: 800～1200ml: 4～6ml adds purified water and glycerol in the effective ingredient mixture, stir, normal temperature drying to 800～1200ml, then be ground into fine powder, both obtained patent medicine.
Preparation method of the present invention is simple, has given full play to the effect of American-cockroach-extract, has effectively improved the curative effect to the ulcerative colitis disease.
The specific embodiment
The specific embodiment below in conjunction with embodiment is described in further detail foregoing of the present invention again:
A kind of American cockroach medicament composition for the treatment of ulcerative colitis, described pharmaceutical composition is mainly to mix by American-cockroach-extract, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci the effective ingredient compositions of mixtures made, by weight, its proportioning is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2～10: 3～12: 6～15: 6～15: 9～15.Optimum ratio is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=6: 4: 12: 8: 13.
Described pharmaceutical composition also comprises purified water and glycerol, and with the effective ingredient mixture of 1000g weighing scale, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800～1200ml: 4～6ml.The proportioning of preferred version is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
The preparation method of the American cockroach medicament composition for the treatment of ulcerative colitis comprises the following steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: dry periplaneta americana is pulverized, made the periplaneta americana coarse powder, standby;
B, immersion: add the water of 3～5 times of amounts according to the coarse powder of every 100kg, soak under the temperature conditions of 70～78 ℃ and make the coarse powder mixed liquor in 0.5～2 hour, standby; Wherein, preferred version is: the amount that adds water is 4 times of amounts, and soak time is 1 hour, and soaking temperature is 74 ℃;
C, three extractions: the coarse powder mixed liquor adopts the method decocted to carry out three times and extracts, and when the coarse powder mixed liquor is extracted for the first time, extraction time is 7～9 hours; Then after the water that adds remaining 2～4 times of amounts of liquid in the remaining liquid after extracting for the first time, extract for the second time, extraction time is 5～7 hours; More than adding in the most backward remaining liquid after extracting for the second time, after the water of 2～4 times of amounts of liquid, extract for the third time, extraction time is 3～5 hours, makes respectively the extracting solution of three times, standby;
D, filtration for the first time: the extracting solution of three times are merged and mix, then filter and make one-level filtrate, standby;
E, concentrated for the first time: the one-level concentrated solution that when one-level filtrate is concentrated into to 70～90 ℃, relative density is 1.05～1.25, standby;
F, alcoholization are processed: add gradually the ethanol that concentration is 93～97%w/w in the one-level concentrated solution, and fully stir, make it contain the alcohol amount and reach till 45～55%, be incubated 20～40 minutes under the temperature conditions of 70～90 ℃, then standing 10～14 hours, make solution of alcoholized, standby;
G, filtration for the second time: solution of alcoholized is discarded to the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate, standby;
H, concentrated for the second time: after secondary filtrate is carried out to the ethanol recycling, the secondary concentrated solution that while being concentrated into 70～90 ℃, relative density is 1.15～1.30, standby;
I, unguentum preparation: the secondary concentrated solution is concentrated under condition of normal pressure to the unguentum of moisture≤25～35%, obtains American-cockroach-extract-containing, standby;
2., weighing: by American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2～10: 3～12: 6～15: 6～15: 9～15 weight part ratio carries out weighing, standby;
3., decoct: Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add for the first time 5～7 times of amounts of water, decoct 2～4 hours, rear 3～5 times of amounts of water that at every turn add for twice, decoct 1～3 hour, and the decocting liquid after then three times being decocted filters, filtrate merges, filter through sheet frame again, be concentrated into 1000ml, make the decoction mixed liquor standby;
4., the mixing of effective ingredient: by American-cockroach-extract with decoct mixed liquor and mixed merging, stir, make the effective ingredient mixture, standby;
5., patent medicine: according to the effective ingredient mixture: the weight ratio of purified water: glycerol=1000g: 800～1200ml: 4～6ml adds purified water and glycerol in the effective ingredient mixture, stir, normal temperature drying to 800～1200ml, then be ground into fine powder, both obtained patent medicine.
Embodiment 1
Implemented according to the method described above, by dry periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, and after soaking 0.5 hour, temperature, about 70 ℃, is extracted three times, 7 hours for the first time; Add for the second time water 200Kg, extract 5 hours; Add for the third time water 200Kg, extract 3 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.05～1.08 (70 ℃), add the ethanol that concentration is 93%w/w, making into containing the alcohol amount is 40%, 70 ℃ of insulated and stirred 20 minutes, standing 10 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15～1.18 (70 ℃), normal pressure is concentrated into the cream of moisture≤25%, obtains American-cockroach-extract-containing, standby; By American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2: 3: 6: the weight part ratio of 6: 9 carries out weighing, standby; Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add for the first time 5 times of amounts of water, decoct 2 hours, the rear 3 times of amounts of water that at every turn add for twice, decoct 1 hour, the decocting liquid after then three times being decocted filters, and filtrate merges, filter through sheet frame again, be concentrated into 1000ml, make the decoction mixed liquor standby; American-cockroach-extract is mixed to merging with the decoction mixed liquor, stirred, made the effective ingredient mixture, standby; Then press the effective ingredient mixture: purified water: glycerol=1000g: 800ml: 4ml, add purified water and glycerol, stir, normal temperature drying, to 800ml, then is ground into fine powder, has both obtained patent medicine.
Embodiment 2
Implemented according to the method described above, by dry periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, and after soaking 0.5 hour, temperature, about 70 ℃, is extracted three times, 7 hours for the first time; Add for the second time water 200Kg, extract 5 hours; Add for the third time water 200Kg, extract 3 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.05～1.08 (70 ℃), add the ethanol that concentration is 93%w/w, making into containing the alcohol amount is 40%, 70 ℃ of insulated and stirred 20 minutes, standing 10 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15～1.18 (70 ℃), normal pressure is concentrated into the cream of moisture≤25%, obtains American-cockroach-extract-containing, standby; By American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=10: 12: 15: the weight part ratio of 15: 15 carries out weighing, standby; Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add for the first time 7 times of amounts of water, decoct 4 hours, the rear 5 times of amounts of water that at every turn add for twice, decoct 3 hours, the decocting liquid after then three times being decocted filters, and filtrate merges, filter through sheet frame again, be concentrated into 1000ml, make the decoction mixed liquor standby; American-cockroach-extract is mixed to merging with the decoction mixed liquor, stirred, made the effective ingredient mixture, standby; Then press the effective ingredient mixture: purified water: glycerol=1000g: 1200ml: 6ml, add purified water and glycerol, stir, normal temperature drying, to 1200ml, then is ground into fine powder, has both obtained patent medicine.
Embodiment 3
Implemented according to the method described above, by dry periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, and after soaking 0.5 hour, temperature, about 70 ℃, is extracted three times, 7 hours for the first time; Add for the second time water 200Kg, extract 5 hours; Add for the third time water 200Kg, extract 3 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.05～1.08 (70 ℃), add the ethanol that concentration is 93%w/w, making into containing the alcohol amount is 40%, 70 ℃ of insulated and stirred 20 minutes, standing 10 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15～1.18 (70 ℃), normal pressure is concentrated into the cream of moisture≤25%, obtains American-cockroach-extract-containing, standby; By American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=6: 4: 12: the weight part ratio of 8: 13 carries out weighing, standby; Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add for the first time 6 times of amounts of water, decoct 3 hours, the rear 4 times of amounts of water that at every turn add for twice, decoct 2 hours, the decocting liquid after then three times being decocted filters, and filtrate merges, filter through sheet frame again, be concentrated into 1000ml, make the decoction mixed liquor standby; American-cockroach-extract is mixed to merging with the decoction mixed liquor, stirred, made the effective ingredient mixture, standby; Then press the effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml, add purified water and glycerol, stir, normal temperature drying, to 1000ml, then is ground into fine powder, has both obtained patent medicine.
Embodiment 4
Implemented according to the method described above, by dry periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, and after soaking 0.5 hour, temperature, about 70 ℃, is extracted three times, 7 hours for the first time; Add for the second time water 200Kg, extract 5 hours; Add for the third time water 200Kg, extract 3 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.05～1.08 (70 ℃), add the ethanol that concentration is 93%w/w, making into containing the alcohol amount is 40%, 70 ℃ of insulated and stirred 20 minutes, standing 10 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15～1.18 (70 ℃), normal pressure is concentrated into the cream of moisture≤25%, obtains American-cockroach-extract-containing, standby; By American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=3: 4.8: 11: the weight part ratio of 9.3: 13.7 carries out weighing, standby; Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add for the first time 6 times of amounts of water, decoct 3 hours, the rear 4 times of amounts of water that at every turn add for twice, decoct 2 hours, the decocting liquid after then three times being decocted filters, and filtrate merges, filter through sheet frame again, be concentrated into 1000ml, make the decoction mixed liquor standby; American-cockroach-extract is mixed to merging with the decoction mixed liquor, stirred, made the effective ingredient mixture, standby; Then press the effective ingredient mixture: purified water: glycerol=1000g: 900ml: 5.5ml, add purified water and glycerol, stir, normal temperature drying, to 900ml, then is ground into fine powder, has both obtained patent medicine.
Test example: the clinical testing data of patients of ulcerative colitis cure rate
One, physical data:
The patients of ulcerative colitis number refers to each table, meets diagnostic criteria.Be divided at random treatment group and matched group, the men and women does not wait, 18～50 years old age; Two groups of patient ages, sex and courses of disease are learned processing by statistics, and no significant difference, have comparability.
Two, Therapeutic Method:
Treatment group: this programme medicine, oral, 0.8～1.2g is grown up one time;
Matched group: olsalazine sodium capsule, oral, 3 times on the one, each 3, during dining, take;
Three, clinical testing data (in Table 1,2, n number of delegates wherein, percentages is taked to round up and retained 2 significant digits)
Table 1: two groups of curative effects relatively
Table 2: two groups of 30 days curative effects relatively
| Group | n | 30 days healing patient numbers | 30 days cure rates (%) |
| Treatment group | 62 | 58 | 93.55 |
| Matched group | 50 | 31 | 62 |
Comprehensive conclusion: from above-mentioned clinical data, the treatment group curative effect obviously is better than matched group.
Ulcerative colitis is common clinical, can occur in any age, and the characteristics of outbreak are repeatedly arranged.The generation of above-mentioned disease is relevant with many factors, common are infection, immunity, zinc deficiency etc.The medicine such as Cortex Phellodendri, Fructus Forsythiae is a kind of medicine that is usually used in treating above-mentioned disease, and certain curative effect is arranged.Periplaneta americana is a kind of insecticide, be commonly called as Blatta seu periplaneta, body contains the various active composition, its extract main component is polyalcohols and peptide class active substance, confirm to have promotion epithelial cell, granulation tissue growth through pharmacological research, promote wound repair, strengthen immune effect, but do not have antibacterial action, the medicines such as American-cockroach-extract and Cortex Phellodendri, Fructus Forsythiae collocation is used, not only can infection, can promote the chronic ulcer tissue reparation simultaneously, improve ulcer healing rate, shorten healing, it is more effective that both share the above-mentioned disease for the treatment of.
Oral olsalazine sodium capsule untoward reaction: suffer from diarrhoea the most common, usually of short duration, when treatment starts or increase dosage, occur, after the minimizing consumption, can alleviate; Other untoward reaction for headache, feel sick, stomachache, erythra, dizziness and arthralgia.
Claims (2)
1. an American cockroach medicament composition for the treatment of ulcerative colitis, it is characterized in that: described pharmaceutical composition is mainly to mix by American-cockroach-extract, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci the effective ingredient compositions of mixtures made, by weight, its proportioning is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=6: 4: 12: 8: 13;
The preparation method of described American-cockroach-extract comprises the following steps:
A, coarse crushing: dry periplaneta americana is pulverized, made the periplaneta americana coarse powder, standby;
B, immersion: add the water of 3～5 times of amounts according to the coarse powder of every 100kg, soak under the temperature conditions of 70～78 ℃ and make the coarse powder mixed liquor in 0.5～2 hour, standby;
C, three extractions: the coarse powder mixed liquor adopts the method decocted to carry out three times and extracts, and when the coarse powder mixed liquor is extracted for the first time, extraction time is 7～9 hours; Then after the water that adds remaining 2～4 times of amounts of liquid in the remaining liquid after extracting for the first time, extract for the second time, extraction time is 5～7 hours; More than adding in the most backward remaining liquid after extracting for the second time, after the water of 2～4 times of amounts of liquid, extract for the third time, extraction time is 3～5 hours, makes respectively the extracting solution of three times, standby;
D, filtration for the first time: the extracting solution of three times are merged and mix, then filter and make one-level filtrate, standby;
E, concentrated for the first time: the one-level concentrated solution that when one-level filtrate is concentrated into to 70～90 ℃, relative density is 1.05～1.25, standby;
F, alcoholization are processed: add gradually the ethanol that concentration is 93～97%w/w in the one-level concentrated solution, and fully stir, make it contain the alcohol amount and reach till 45～55%, be incubated 20～40 minutes under the temperature conditions of 70～90 ℃, then standing 10～14 hours, make solution of alcoholized, standby;
G, filtration for the second time: solution of alcoholized is discarded to the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate, standby;
H, concentrated for the second time: after secondary filtrate is carried out to the ethanol recycling, the secondary concentrated solution that while being concentrated into 70～90 ℃, relative density is 1.15～1.30, standby;
I, unguentum preparation: the secondary concentrated solution is concentrated under condition of normal pressure to the unguentum of moisture≤25～35%, obtains American-cockroach-extract, standby.
2. treat according to claim 1 the American cockroach medicament composition of ulcerative colitis, it is characterized in that: described pharmaceutical composition also comprises purified water and glycerol, with the effective ingredient mixture of 1000g weighing scale, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
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