CN101829220A - Periplaneta Americana pharmaceutical composition for treating ulcerative colitis and preparation method thereof - Google Patents
Periplaneta Americana pharmaceutical composition for treating ulcerative colitis and preparation method thereof Download PDFInfo
- Publication number
- CN101829220A CN101829220A CN201010182408A CN201010182408A CN101829220A CN 101829220 A CN101829220 A CN 101829220A CN 201010182408 A CN201010182408 A CN 201010182408A CN 201010182408 A CN201010182408 A CN 201010182408A CN 101829220 A CN101829220 A CN 101829220A
- Authority
- CN
- China
- Prior art keywords
- american
- standby
- cockroach
- extract
- time
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses a periplaneta Americana pharmaceutical composition for treating ulcerative colitis (short for UC), mainly comprising mixtures of effective components prepared from the following components in parts by weight: 2-10 parts of periplaneta Americana extractive, 3-12 parts of golden cypress, 6-15 parts of fructus forsythiae, 6-15 parts of honeysuckle and 9-15 parts of dandelion. The method for preparing the periplaneta Americana pharmaceutical composition for treating ulcerative colitis comprises the following steps of preparing the periplaneta Americana extractive, weighing, decocting, and mixing the effective components to prepare the medicine composition. The preparation method is simple, gives full play to the periplaneta Americana extractive and effectively improves the curative effect of the ulcerative colitis.
Description
Technical field
The present invention relates to medical technical field, specifically relate to a kind of American cockroach medicament composition for the treatment of ulcerative colitis and preparation method thereof.
Background technology
It is documented that periplaneta americana is the insecticide of volume maximum in the Blattidae, originates in South America, periplaneta americana is traditional Chinese crude drug, is used as medicine its property plug salty in the mouth with dry and bright adult, poisonous, acid is arranged, functions such as dissipating blood stasis, removing food stagnancy, detoxifcation, diuretic, detumescence are arranged; Curing mainly infantile malnutrition, tonsillitis, health enclosed mass, carbuncle skin ulcer swells and ache and Scolopendra, venom etc.
Along with science and technology constantly develops, after years of research and found that in recent years the periplaneta americana epidermis contains sclerotin and chitin, elements such as bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium; Muscle hydrolysis 13 seed amino acids; Its alcohol extract has the obvious suppression effect to cancerous cell, and cardiovascular disease is had tangible curative effect.In addition, health storage vitamin B
1, B
2, nicotinic acid and ascorbic acid etc., lymph contain trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc.All contain ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.Clinical main application has: treat infantile malnutrition, control the carbuncle pyogenic infections from tumour or sore, control the Scolopendra wound, control innominate toxic swelling, control the worm venom.But also have periplaneta americana and medical herbs compatibility auxiliary treatment colon cancer.American-cockroach-extract can be controlled hepatitis B, and extract A T-2 preparation can cure mainly primary hepatocarcinoma, cardiovascular disease etc.
Notification number is CN 100525781C, name is called " American-cockroach-extract; contain pharmaceutical composition of this extract and preparation method thereof " and publication number is CN1943600A, it is two with the American-cockroach-extract relevant patent documentations of applicant in application in 2006 that name is called " pharmaceutical composition and the new purposes thereof that contain periplaneta americana and ethanol extraction thereof ", it discloses the preparation method and the part medical usage of American-cockroach-extract, in recent years, along with the further research to American-cockroach-extract, American-cockroach-extract has obtained further development in purposes pharmaceutically.
Cortex Phellodendri is used for damp-heat dysentery, jaundice, and leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Salt Flos Lonicerae nourishing YIN to lower pathogenic fire.Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency.
Fructus Forsythiae, heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Flos Lonicerae, heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of wine Flos Lonicerae is burning hot.Be used for conjunctival congestion, aphtha.Rhizoma Zingiberis Recens Flos Lonicerae clearing stomach stomach function regulating preventing or arresting vomiting.Be used for cold and heat and tie mutually, damp and hot middle resistance, feeling of fullness vomiting.Cornel Flos Lonicerae soothing liver-QI stomach function regulating preventing or arresting vomiting.Be used for incoordination between the liver and stomach, the vomiting acid regurgitation.
Herba Taraxaci, purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.The wine Herba Taraxaci is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.Be used for the conjunctival congestion pharyngeal swelling, gingivitis.Ripe Herba Taraxaci rushes down exerts oneself to delay eliminating fire and detoxication.Be used for pathogenic fire,toxin and furuncles.The hemostasis of dandelion charcoal cooling blood and removing stasis.Be used for heat in blood stasis of blood bleeder is arranged.
Yet Clinical results shows that above-mentioned medical material is to the not good enough or inefficacy of treatment ulcerative colitis effect.
Summary of the invention
The objective of the invention is to overcome above-mentioned technical deficiency, a kind of American cockroach medicament composition and preparation method thereof of treatment ulcerative colitis of effective raising cure rate is provided.
Purpose of the present invention is achieved through the following technical solutions: a kind of American cockroach medicament composition for the treatment of ulcerative colitis, described pharmaceutical composition mainly is made up of the mixed effective ingredient mixture that gets of American-cockroach-extract, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci, by weight than, its proportioning is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2~10: 3~12: 6~15: 6~15: 9~15.Optimum ratio is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=6: 4: 12: 8: 13.
Described pharmaceutical composition also comprises purified water and glycerol, and in the effective ingredient mixture of 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800~1200ml: 4~6ml.The proportioning of preferred version is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
The preparation method of the American cockroach medicament composition of treatment ulcerative colitis may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder, standby;
B, immersion: add the water of 3~5 times of amounts according to the coarse powder of every 100kg, under 70~78 ℃ temperature conditions, soak and made the coarse powder mixed liquor in 0.5~2 hour, standby; Wherein, preferred version is: the amount that adds entry is 4 times of amounts, and soak time is 1 hour, and soaking temperature is 74 ℃;
C, three extractions: the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and when the coarse powder mixed liquor was carried out extracting the first time, extraction time was 7~9 hours; Carry out the second time then behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5~7 hours; Extract for the third time behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3~5 hours, makes three times extracting solution respectively, and is standby;
D, filtration for the first time: three times extracting solution are merged mixing, filter then and make one-level filtrate, standby;
E, concentrated for the first time: relative density was 1.05~1.25 one-level concentrated solution when one-level filtrate was concentrated into 70~90 ℃, and is standby;
F, alcoholization are handled: add the ethanol that concentration is 93~97%w/w gradually in the one-level concentrated solution, and fully stir, make it contain the alcohol amount and reach till 45~55%, under 70~90 ℃ temperature conditions, be incubated 20~40 minutes, left standstill then 10~14 hours, and made solution of alcoholized, standby;
G, filtration for the second time: solution of alcoholized is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate, and is standby;
H, the second time concentrate: after secondary filtrate was carried out the ethanol recycling, relative density is 1.15~1.30 secondary concentrated solution when being concentrated into 70~90 ℃, and was standby;
The preparation of i, unguentum: the secondary concentrated solution is concentrated into the unguentum of moisture≤25~35% under condition of normal pressure, promptly gets American-cockroach-extract-containing, standby;
2., weighing: by American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2~10: 3~12: 6~15: 6~15: 9~15 weight part ratio carries out weighing, and is standby;
3., decoct: Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add for the first time 5~7 times of amounts of water, decocted 2~4 hours, the back adds 3~5 times of amounts of water twice at every turn, decocts 1~3 hour, and the decocting liquid after then three times being decocted filters, filtrate merges, filter through sheet frame, be concentrated into 1000ml, it is standby to make the decoction mixed liquor;
4., mixing active ingredients: with American-cockroach-extract and decoct mixed liquor mixing merging, stir, make the effective ingredient mixture, standby;
5., patent medicine: according to the effective ingredient mixture: the weight ratio of purified water: glycerol=1000g: 800~1200ml: 4~6ml adds purified water and glycerol in the effective ingredient mixture, stir, normal temperature drying to 800~1200ml is ground into fine powder then, has both got patent medicine.
Preparation method of the present invention is simple, has given full play to the effect of American-cockroach-extract, has effectively improved the curative effect to the ulcerative colitis disease.
The specific embodiment
The specific embodiment below in conjunction with embodiment is described in further detail foregoing of the present invention again:
A kind of American cockroach medicament composition for the treatment of ulcerative colitis, described pharmaceutical composition mainly is made up of the mixed effective ingredient mixture that gets of American-cockroach-extract, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci, by weight than, its proportioning is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2~10: 3~12: 6~15: 6~15: 9~15.Optimum ratio is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=6: 4: 12: 8: 13.
Described pharmaceutical composition also comprises purified water and glycerol, and in the effective ingredient mixture of 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800~1200ml: 4~6ml.The proportioning of preferred version is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
The preparation method of the American cockroach medicament composition of treatment ulcerative colitis may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder, standby;
B, immersion: add the water of 3~5 times of amounts according to the coarse powder of every 100kg, under 70~78 ℃ temperature conditions, soak and made the coarse powder mixed liquor in 0.5~2 hour, standby; Wherein, preferred version is: the amount that adds entry is 4 times of amounts, and soak time is 1 hour, and soaking temperature is 74 ℃;
C, three extractions: the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and when the coarse powder mixed liquor was carried out extracting the first time, extraction time was 7~9 hours; Carry out the second time then behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5~7 hours; Extract for the third time behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3~5 hours, makes three times extracting solution respectively, and is standby;
D, filtration for the first time: three times extracting solution are merged mixing, filter then and make one-level filtrate, standby;
E, concentrated for the first time: relative density was 1.05~1.25 one-level concentrated solution when one-level filtrate was concentrated into 70~90 ℃, and is standby;
F, alcoholization are handled: add the ethanol that concentration is 93~97%w/w gradually in the one-level concentrated solution, and fully stir, make it contain the alcohol amount and reach till 45~55%, under 70~90 ℃ temperature conditions, be incubated 20~40 minutes, left standstill then 10~14 hours, and made solution of alcoholized, standby;
G, filtration for the second time: solution of alcoholized is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate, and is standby;
H, the second time concentrate: after secondary filtrate was carried out the ethanol recycling, relative density is 1.15~1.30 secondary concentrated solution when being concentrated into 70~90 ℃, and was standby;
The preparation of i, unguentum: the secondary concentrated solution is concentrated into the unguentum of moisture≤25~35% under condition of normal pressure, promptly gets American-cockroach-extract-containing, standby;
2., weighing: by American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2~10: 3~12: 6~15: 6~15: 9~15 weight part ratio carries out weighing, and is standby;
3., decoct: Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add for the first time 5~7 times of amounts of water, decocted 2~4 hours, the back adds 3~5 times of amounts of water twice at every turn, decocts 1~3 hour, and the decocting liquid after then three times being decocted filters, filtrate merges, filter through sheet frame, be concentrated into 1000ml, it is standby to make the decoction mixed liquor;
4., mixing active ingredients: with American-cockroach-extract and decoct mixed liquor mixing merging, stir, make the effective ingredient mixture, standby;
5., patent medicine: according to the effective ingredient mixture: the weight ratio of purified water: glycerol=1000g: 800~1200ml: 4~6ml adds purified water and glycerol in the effective ingredient mixture, stir, normal temperature drying to 800~1200ml is ground into fine powder then, has both got patent medicine.
Embodiment 1
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.05~1.08 (70 ℃), adding concentration is the ethanol of 93%w/w, makes that to become to contain the alcohol amount be 40%, 70 ℃ of insulated and stirred 20 minutes, left standstill 10 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15~1.18 (70 ℃), normal pressure is concentrated into the cream of moisture≤25%, promptly gets American-cockroach-extract-containing, and is standby; By American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2: 3: 6: 6: 9 weight part ratio carries out weighing, and is standby; Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add 5 times of amounts of water for the first time, decocted 2 hours, the back adds 3 times of amounts of water twice at every turn, decocted 1 hour, the decocting liquid after then three times being decocted filters, and filtrate merges, filter through sheet frame, be concentrated into 1000ml, it is standby to make the decoction mixed liquor; With American-cockroach-extract and decoction mixed liquor mixing merging, stir, make the effective ingredient mixture, standby; Press the effective ingredient mixture then: purified water: glycerol=1000g: 800ml: 4ml, add purified water and glycerol, stir, normal temperature drying is ground into fine powder then to 800ml, has both got patent medicine.
Embodiment 2
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.05~1.08 (70 ℃), adding concentration is the ethanol of 93%w/w, makes that to become to contain the alcohol amount be 40%, 70 ℃ of insulated and stirred 20 minutes, left standstill 10 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15~1.18 (70 ℃), normal pressure is concentrated into the cream of moisture≤25%, promptly gets American-cockroach-extract-containing, and is standby; By American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=10: 12: 15: 15: 15 weight part ratio carries out weighing, and is standby; Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add 7 times of amounts of water for the first time, decocted 4 hours, the back adds 5 times of amounts of water twice at every turn, decocted 3 hours, the decocting liquid after then three times being decocted filters, and filtrate merges, filter through sheet frame, be concentrated into 1000ml, it is standby to make the decoction mixed liquor; With American-cockroach-extract and decoction mixed liquor mixing merging, stir, make the effective ingredient mixture, standby; Press the effective ingredient mixture then: purified water: glycerol=1000g: 1200ml: 6ml, add purified water and glycerol, stir, normal temperature drying is ground into fine powder then to 1200ml, has both got patent medicine.
Embodiment 3
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.05~1.08 (70 ℃), adding concentration is the ethanol of 93%w/w, makes that to become to contain the alcohol amount be 40%, 70 ℃ of insulated and stirred 20 minutes, left standstill 10 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15~1.18 (70 ℃), normal pressure is concentrated into the cream of moisture≤25%, promptly gets American-cockroach-extract-containing, and is standby; By American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=6: 4: 12: 8: 13 weight part ratio carries out weighing, and is standby; Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add 6 times of amounts of water for the first time, decocted 3 hours, the back adds 4 times of amounts of water twice at every turn, decocted 2 hours, the decocting liquid after then three times being decocted filters, and filtrate merges, filter through sheet frame, be concentrated into 1000ml, it is standby to make the decoction mixed liquor; With American-cockroach-extract and decoction mixed liquor mixing merging, stir, make the effective ingredient mixture, standby; Press the effective ingredient mixture then: purified water: glycerol=1000g: 1000ml: 5ml, add purified water and glycerol, stir, normal temperature drying is ground into fine powder then to 1000ml, has both got patent medicine.
Embodiment 4
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.05~1.08 (70 ℃), adding concentration is the ethanol of 93%w/w, makes that to become to contain the alcohol amount be 40%, 70 ℃ of insulated and stirred 20 minutes, left standstill 10 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15~1.18 (70 ℃), normal pressure is concentrated into the cream of moisture≤25%, promptly gets American-cockroach-extract-containing, and is standby; By American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=3: 4.8: 11: 9.3: 13.7 weight part ratio carries out weighing, and is standby; Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add 6 times of amounts of water for the first time, decocted 3 hours, the back adds 4 times of amounts of water twice at every turn, decocted 2 hours, the decocting liquid after then three times being decocted filters, and filtrate merges, filter through sheet frame, be concentrated into 1000ml, it is standby to make the decoction mixed liquor; With American-cockroach-extract and decoction mixed liquor mixing merging, stir, make the effective ingredient mixture, standby; Press the effective ingredient mixture then: purified water: glycerol=1000g: 900ml: 5.5ml, add purified water and glycerol, stir, normal temperature drying is ground into fine powder then to 900ml, has both got patent medicine.
Test example: the clinical testing data of patients of ulcerative colitis cure rate
One, physical data:
The patients of ulcerative colitis number sees each table for details, meets diagnostic criteria.Be divided into treatment group and matched group at random, the men and women does not wait, 18~50 years old age; Two groups of patient ages, sex and courses of disease are learned processing by statistics, and difference does not have the significance meaning, has comparability.
Two, Therapeutic Method:
The treatment group: this programme medicine, oral, 0.8~1.2g is grown up one time;
Matched group: the Olsalazine natrium capsule, oral, 3 times on the one, each 3, take during dining;
Three, clinical testing data (see Table 1,2, n number of delegates wherein, percentages is taked to round up and kept 2 significant digits)
Table 1: two groups of curative effects relatively
Table 2: two groups of 30 days curative effects relatively
Group | ??n | 30 days healing patient numbers | 30 days cure rates (%) |
The treatment group | ??62 | ??58 | ??93.55 |
Matched group | ??50 | ??31 | ??62 |
Comprehensive conclusion: by above-mentioned clinical data as seen, treatment group curative effect obviously is better than matched group.
Ulcerative colitis is a common clinical, can occur in any age, and the characteristics of outbreak are repeatedly arranged.The generation of above-mentioned disease is relevant with multiple factor, and common have infection, immunity, zinc deficiency or the like.Medicine such as Cortex Phellodendri, Fructus Forsythiae is a kind of medicine that is usually used in treating above-mentioned disease, and certain curative effect is arranged.Periplaneta americana is a kind of insecticide, be commonly called as Blatta seu periplaneta, body contains the various active composition, its extract main component is polyalcohols and peptide class active substance, confirm to have promotion epithelial cell, granulation tissue growth through pharmacological research, promote wound repair, the effect of enhance immunity, but do not have antibacterial action, medicines such as American-cockroach-extract and Cortex Phellodendri, Fructus Forsythiae collocation is used, not only can infection, simultaneously can promote the chronic ulcer tissue reparation, improve ulcer healing rate, shorten the ulcer healing time, it is more effective that both share the above-mentioned disease of treatment.
The untoward reaction of oral Olsalazine natrium capsule: it is the most common to suffer from diarrhoea, of short duration usually, takes place when treatment beginning or increase dosage, can alleviate behind the minimizing consumption; Other untoward reaction for headache, feel sick, stomachache, erythra, dizziness and arthralgia.
Claims (6)
1. American cockroach medicament composition for the treatment of ulcerative colitis, it is characterized in that: described pharmaceutical composition mainly is made up of the mixed effective ingredient mixture that gets of American-cockroach-extract, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci, by weight than, its proportioning is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2~10: 3~12: 6~15: 6~15: 9~15.
2. according to the American cockroach medicament composition of the described treatment ulcerative colitis of claim 1, it is characterized in that: described American-cockroach-extract, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci by weight than, its proportioning is: American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=6: 4: 12: 8: 13.
3. according to the American cockroach medicament composition of the described treatment ulcerative colitis of claim 1, it is characterized in that: described pharmaceutical composition also comprises purified water and glycerol, in the effective ingredient mixture of 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800~1200ml: 4~6ml.
4. according to the American cockroach medicament composition of the described treatment ulcerative colitis of claim 3, it is characterized in that: described effective ingredient mixture in 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
5. according to the preparation method of the American cockroach medicament composition of the described treatment ulcerative colitis of claim 1, it is characterized in that: described preparation method may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder, standby;
B, immersion: add the water of 3~5 times of amounts according to the coarse powder of every 100kg, under 70~78 ℃ temperature conditions, soak and made the coarse powder mixed liquor in 0.5~2 hour, standby;
C, three extractions: the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and when the coarse powder mixed liquor was carried out extracting the first time, extraction time was 7~9 hours; Carry out the second time then behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5~7 hours; Extract for the third time behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3~5 hours, makes three times extracting solution respectively, and is standby;
D, filtration for the first time: three times extracting solution are merged mixing, filter then and make one-level filtrate, standby;
E, concentrated for the first time: relative density was 1.05~1.25 one-level concentrated solution when one-level filtrate was concentrated into 70~90 ℃, and is standby;
F, alcoholization are handled: add the ethanol that concentration is 93~97%w/w gradually in the one-level concentrated solution, and fully stir, make it contain the alcohol amount and reach till 45~55%, under 70~90 ℃ temperature conditions, be incubated 20~40 minutes, left standstill then 10~14 hours, and made solution of alcoholized, standby;
G, filtration for the second time: solution of alcoholized is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate, and is standby;
H, the second time concentrate: after secondary filtrate was carried out the ethanol recycling, relative density is 1.15~1.30 secondary concentrated solution when being concentrated into 70~90 ℃, and was standby;
The preparation of i, unguentum: the secondary concentrated solution is concentrated into the unguentum of moisture≤25~35% under condition of normal pressure, promptly gets American-cockroach-extract-containing, standby;
2., weighing: by American-cockroach-extract: Cortex Phellodendri: Fructus Forsythiae: Flos Lonicerae: Herba Taraxaci=2~10: 3~12: 6~15: 6~15: 9~15 weight part ratio carries out weighing, and is standby;
3., decoct: Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae and Herba Taraxaci are decocted with water three times, add for the first time 5~7 times of amounts of water, decocted 2~4 hours, the back adds 3~5 times of amounts of water twice at every turn, decocts 1~3 hour, and the decocting liquid after then three times being decocted filters, filtrate merges, filter through sheet frame, be concentrated into 1000ml, it is standby to make the decoction mixed liquor;
4., mixing active ingredients: with American-cockroach-extract and decoct mixed liquor mixing merging, stir, make the effective ingredient mixture, standby;
5., patent medicine: according to the effective ingredient mixture: the weight ratio of purified water: glycerol=1000g: 800~1200ml: 4~6ml adds purified water and glycerol in the effective ingredient mixture, stir, normal temperature drying to 800~1200ml is ground into fine powder then, has both got patent medicine.
6. according to the preparation method of the American cockroach medicament composition of the described treatment ulcerative colitis of claim 5, it is characterized in that: amount of water is 4 times of amounts among the described step b, and soak time is 1 hour, and soaking temperature is 74 ℃.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101824087A CN101829220B (en) | 2010-05-25 | 2010-05-25 | Periplaneta Americana pharmaceutical composition for treating ulcerative colitis and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101824087A CN101829220B (en) | 2010-05-25 | 2010-05-25 | Periplaneta Americana pharmaceutical composition for treating ulcerative colitis and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101829220A true CN101829220A (en) | 2010-09-15 |
CN101829220B CN101829220B (en) | 2013-12-11 |
Family
ID=42713542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010101824087A Active CN101829220B (en) | 2010-05-25 | 2010-05-25 | Periplaneta Americana pharmaceutical composition for treating ulcerative colitis and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101829220B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114073720A (en) * | 2020-08-10 | 2022-02-22 | 大理大学 | Compound traditional Chinese medicine for treating damp-heat type ulcerative colitis and preparation method and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1048325A (en) * | 1990-07-25 | 1991-01-09 | 吴光忠 | The preparation method of skin ointment for healing ulcered wound |
-
2010
- 2010-05-25 CN CN2010101824087A patent/CN101829220B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1048325A (en) * | 1990-07-25 | 1991-01-09 | 吴光忠 | The preparation method of skin ointment for healing ulcered wound |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114073720A (en) * | 2020-08-10 | 2022-02-22 | 大理大学 | Compound traditional Chinese medicine for treating damp-heat type ulcerative colitis and preparation method and application thereof |
CN114073720B (en) * | 2020-08-10 | 2023-03-21 | 大理大学 | Compound traditional Chinese medicine for treating damp-heat type ulcerative colitis and preparation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
CN101829220B (en) | 2013-12-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102488848B (en) | Traditional Chinese medicine composition used for treating high-pathogenicity porcine reproductive and respiratory syndrome, preparation method thereof, and application thereof | |
CN101837018A (en) | American cockroach medicinal composition for curing ulcers or ulcerative inflammation and preparation method thereof | |
CN104208245B (en) | Tinea manus and pedis Traditional Chinese medicine medicated bath and preparation method | |
CN103536826B (en) | One is treated colpitic Chinese medicine composition and preparation method thereof | |
CN101837095B (en) | American cockroach medicinal composition for curing gastritis and peptic ulcers and preparation method thereof | |
CN101837019B (en) | American cockroach medicinal composition for curing oral ulcers and preparation method thereof | |
CN113197974A (en) | Chinese medicinal composition for treating gastritis, gastric ulcer and duodenal ulcer | |
CN101837045A (en) | American cockroach medicinal composition for curing oral ulcers and preparation method thereof | |
CN1319403A (en) | Medicine for treating allergic purpura | |
CN101829178A (en) | Medicine composition for treating diaper rash and preparation method thereof | |
CN101829219B (en) | Periplaneta Americana pharmaceutical composition for treating ulcerative colitis and preparation method thereof | |
CN101837022A (en) | American cockroach medicinal composition for curing gastritis and peptic ulcers and preparation method thereof | |
CN101829220B (en) | Periplaneta Americana pharmaceutical composition for treating ulcerative colitis and preparation method thereof | |
CN101829221B (en) | American cockroach medicament composition for treating piles and anal fissure and preparation method thereof | |
CN101829193B (en) | Medicine composite for treating cervical erosion and preparation method thereof | |
CN101822696B (en) | Medicine composite for treating burn and scald and preparation method thereof | |
CN102178866A (en) | Chinese medicinal preparation for dispelling damp, promoting blood circulation, softening hard mass and eliminating stagnation for people with qi-depression and blood-stagnation physique, preparation method thereof and application thereof | |
CN101829167B (en) | Medicine composite for treating cervical erosion and preparation method thereof | |
CN101829253B (en) | Medicine composite for treating cervical erosion and preparation method thereof | |
CN101837023A (en) | American cockroach medicinal composition for curing gastritis and peptic ulcers and preparation method thereof | |
CN101829162A (en) | Pharmaceutical composition for treating allergic rhinitis and preparation method thereof | |
CN105477384A (en) | Traditional Chinese medicine composition capable of reducing blood pressure and preparation method of composition | |
CN104225343A (en) | Chinese herbal preparation for treating urinary tract infection and preparation method thereof | |
CN105106261A (en) | Traditional Chinese medicine composition for treating lymphoma | |
CN104274708A (en) | Traditional Chinese medicine for treating hyperthyroidism |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200819 Address after: 615000 Liangshan Yi Autonomous Prefecture, Xichang province Sichuan Airport Road Patentee after: SICHUAN GOODDOCTOR PANXI PHARMACEUTICAL Co.,Ltd. Address before: 15, building 88, building B, four Wei building, No. 610031 Camp Road, Sichuan, Chengdu Patentee before: Geng Funeng |
|
TR01 | Transfer of patent right |