CN101829178A - Medicine composition for treating diaper rash and preparation method thereof - Google Patents
Medicine composition for treating diaper rash and preparation method thereof Download PDFInfo
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- CN101829178A CN101829178A CN201010182518A CN201010182518A CN101829178A CN 101829178 A CN101829178 A CN 101829178A CN 201010182518 A CN201010182518 A CN 201010182518A CN 201010182518 A CN201010182518 A CN 201010182518A CN 101829178 A CN101829178 A CN 101829178A
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- 206010012444 Dermatitis diaper Diseases 0.000 title claims abstract description 37
- 208000003105 Diaper Rash Diseases 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000003814 drug Substances 0.000 title claims abstract description 24
- 239000000203 mixture Substances 0.000 title claims abstract description 9
- 229940079593 drug Drugs 0.000 title description 4
- 239000000284 extract Substances 0.000 claims abstract description 62
- 241000238675 Periplaneta americana Species 0.000 claims abstract description 20
- 238000002156 mixing Methods 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 61
- 239000000706 filtrate Substances 0.000 claims description 47
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 36
- 238000001914 filtration Methods 0.000 claims description 30
- 239000002674 ointment Substances 0.000 claims description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 15
- 238000000605 extraction Methods 0.000 claims description 13
- 239000008213 purified water Substances 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 238000009835 boiling Methods 0.000 claims description 11
- 239000012141 concentrate Substances 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 235000014593 oils and fats Nutrition 0.000 claims description 7
- 238000004064 recycling Methods 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 239000000890 drug combination Substances 0.000 claims description 5
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims description 3
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 14
- 231100000331 toxic Toxicity 0.000 abstract description 3
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- 238000003809 water extraction Methods 0.000 description 4
- 230000035876 healing Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 208000015817 Infant Nutrition disease Diseases 0.000 description 2
- WWNNZCOKKKDOPX-UHFFFAOYSA-N N-methylnicotinate Chemical compound C[N+]1=CC=CC(C([O-])=O)=C1 WWNNZCOKKKDOPX-UHFFFAOYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
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- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
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- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- BRTLKRNVNFIOPJ-UHFFFAOYSA-N Betaine homarine Chemical compound C[N+]1=CC=CC=C1C([O-])=O BRTLKRNVNFIOPJ-UHFFFAOYSA-N 0.000 description 1
- DHHFDKNIEVKVKS-FMOSSLLZSA-N Betanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC(C[C@H]2C([O-])=O)=C1[N+]2=C\C=C\1C=C(C(O)=O)N[C@H](C(O)=O)C/1 DHHFDKNIEVKVKS-FMOSSLLZSA-N 0.000 description 1
- DHHFDKNIEVKVKS-MVUYWVKGSA-N Betanin Natural products O=C(O)[C@@H]1NC(C(=O)O)=C/C(=C\C=[N+]/2\[C@@H](C(=O)[O-])Cc3c\2cc(O)c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)c3)/C1 DHHFDKNIEVKVKS-MVUYWVKGSA-N 0.000 description 1
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- 229920002101 Chitin Polymers 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
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- 239000001263 FEMA 3042 Substances 0.000 description 1
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- 102000003886 Glycoproteins Human genes 0.000 description 1
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- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- SSISHJJTAXXQAX-ZETCQYMHSA-N L-ergothioneine Chemical compound C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC(=S)N1 SSISHJJTAXXQAX-ZETCQYMHSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
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- 241000238661 Periplaneta Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 102100029677 Trehalase Human genes 0.000 description 1
- 108010087472 Trehalase Proteins 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
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- 235000009392 Vitis Nutrition 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 230000009471 action Effects 0.000 description 1
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- 229960000643 adenine Drugs 0.000 description 1
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000012677 beetroot red Nutrition 0.000 description 1
- 239000001654 beetroot red Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000002185 betanin Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
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- 239000002934 diuretic Substances 0.000 description 1
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- 229940093497 ergothioneine Drugs 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
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- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
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- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
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- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
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- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine composition for treating diaper rash, which is mainly prepared by mixing 100 parts by weight of American cockroach extracts and the active components of 2-300 parts by weight of lithospermum. The preparation method of the medicine composition for treating diaper rash comprises the following steps of: extracting the American cockroach extracts, extracting the active components of the lithospermum, and then mixing the American cockroach extracts and the active components of the lithospermum into the medicine composition. The medicine composition has simple preparation method, fully exerts the functions of the American cockroach extracts, effectively improves the curative effect on diaper rash, has the advantages of convenient use and small toxic and side effect, and is a new medicament worth of being generalized.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of pharmaceutical composition for the treatment of diaper rash and preparation method thereof.
Background technology
It is documented that periplaneta americana is the insecticide of volume maximum in the Blattidae, originates in South America, periplaneta americana is traditional Chinese crude drug, is used as medicine its property plug salty in the mouth with dry and bright adult, poisonous, acid is arranged, functions such as dissipating blood stasis, removing food stagnancy, detoxifcation, diuretic, detumescence are arranged; Curing mainly infantile malnutrition, tonsillitis, health enclosed mass, carbuncle skin ulcer swells and ache and Scolopendra, venom etc.
Along with science and technology constantly develops, after years of research and found that in recent years the periplaneta americana epidermis contains sclerotin and chitin, elements such as bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium; Muscle hydrolysis 13 seed amino acids; Its alcohol extract has the obvious suppression effect to cancerous cell, and cardiovascular disease is had tangible curative effect.In addition, health storage vitamin B
1, B
2, nicotinic acid and ascorbic acid etc., lymph contain trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc.All contain ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.Clinical main application has: treat infantile malnutrition, control the carbuncle pyogenic infections from tumour or sore, control the Scolopendra wound, control innominate toxic swelling, control the worm venom.But also have periplaneta americana and medical herbs compatibility auxiliary treatment colon cancer.American-cockroach-extract can be controlled hepatitis B, and extract A T-2 preparation can cure mainly primary hepatocarcinoma, cardiovascular disease etc.
Notification number is CN 100525781C, name is called " American-cockroach-extract; contain pharmaceutical composition of this extract and preparation method thereof " and publication number is CN1943600A, it is two with the American-cockroach-extract relevant patent documentations of applicant in application in 2006 that name is called " pharmaceutical composition and the new purposes thereof that contain periplaneta americana and ethanol extraction thereof ", it discloses the preparation method and the part medical usage of American-cockroach-extract, in recent years, along with the further research to American-cockroach-extract, American-cockroach-extract has obtained further development in purposes pharmaceutically.
Baby's skin is very tender and lovely, if long period of soaking is in urine or airtight and moist because of diaper, buttocks regular meeting red little measles or skin occur and becomes more coarse, is called " diaper rash " or " red hip ".Causing the reason of diaper rash to have a lot, might be because a kind of new food also might be that baby's oneself urine is caused.
Along with growth in the living standard, people transfer active treatment to for the attitude of " diaper rash " by ignoring, and some have also occurred and have been used for the treatment of the medicine of diaper rash, as the healthy and free from worry happiness of baby, the baby of Johnson ﹠ Johnson stern protection cream, tannic acid ointment etc.Yet these medicines mostly are chemicals, more or less exist ill effect for this with regard to tender and lovely infant skin.
Yet existing medicine still is difficult to fully up to expectations for the treatment diaper rash.For this reason, the invention provides a kind of new pharmaceutical composition that is used for the treatment of diaper rash.
Summary of the invention
The objective of the invention is to: overcome above-mentioned deficiency of the prior art, a kind of pharmaceutical composition and preparation method thereof of treatment diaper rash of effective raising cure rate is provided.
Purpose of the present invention is achieved through the following technical solutions: a kind of pharmaceutical composition for the treatment of diaper rash is provided, it is characterized in that: the main component of described pharmaceutical composition and mass parts thereof are such as shown in down: 100 parts of American-cockroach-extracts; 2～300 parts of Radix Arnebiae (Radix Lithospermi)s.
The proportioning of one of preferred version of the pharmaceutical composition of above-mentioned treatment diaper rash is: 100 parts of American-cockroach-extracts; 150 parts of Radix Arnebiae (Radix Lithospermi)s.
Two proportioning of the preferred version of the pharmaceutical composition of above-mentioned treatment diaper rash is: 100 parts of American-cockroach-extracts; 200 parts of Radix Arnebiae (Radix Lithospermi)s.
The preparation of drug combination method of above-mentioned treatment diaper rash may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: will add the water of 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Carry out the second time then behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5～7 hours; Extract for the third time behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrate;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the one-level filtrate in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that makes in step e gradually, and fully stir, making it contain the alcohol amount reaches till 45%～55%, under 70 ℃～90 ℃ temperature conditions, be incubated 20～40 minutes, left standstill then 10～14 hours, and made solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate;
H, the second time concentrate: after the secondary filtrate in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration, after filtrate is boiled 30 minutes, be chilled to room temperature, promptly get American-cockroach-extract, standby;
2., Radix Arnebiae (Radix Lithospermi) decocted with water extracts three times, add 4-6 times of water gaging for the first time, extracted 6-10 hour; For the second time add 2-4 times of water gaging, extracted 4-8 hour; Add 2-4 times of water gaging for the third time, extracted 2-6 hour; Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.10～1.20 (80 ℃), being evaporated to relative density was 1.20～1.25 (80 ℃), and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 20-40 minute, and is standby;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, the filtrate concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
In sum, the preparation of drug combination method that is used for the treatment of diaper rash provided by the present invention is simple, and has given full play to the effect of American-cockroach-extract, has effectively improved the curative effect to diaper rash, and easy to use, toxic and side effects is little, is a kind of new medicine that is worthy to be popularized.
The specific embodiment
Below in conjunction with embodiment the specific embodiment of the present invention is described in further detail:
The main component of the pharmaceutical composition of treatment diaper rash provided by the present invention and mass parts ratio thereof are: 100 parts of American-cockroach-extracts; 2～300 parts of Radix Arnebiae (Radix Lithospermi)s.
The proportioning of one of preferred version of the pharmaceutical composition of above-mentioned treatment diaper rash is: 100 parts of American-cockroach-extracts; 150 parts of Radix Arnebiae (Radix Lithospermi)s.
Two proportioning of the preferred version of the pharmaceutical composition of above-mentioned treatment diaper rash is: 100 parts of American-cockroach-extracts; 200 parts of Radix Arnebiae (Radix Lithospermi)s.
The preparation of drug combination method of above-mentioned treatment diaper rash may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: will add the water of 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Carry out the second time then behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5～7 hours; Extract for the third time behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrate;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the one-level filtrate in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that makes in step e gradually, and fully stir, making it contain the alcohol amount reaches till 45%～55%, under 70 ℃～90 ℃ temperature conditions, be incubated 20～40 minutes, left standstill then 10～14 hours, and made solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate;
H, the second time concentrate: after the secondary filtrate in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
2., Radix Arnebiae (Radix Lithospermi) decocted with water extracts three times, add 4-6 times of water gaging for the first time, extracted 6-10 hour; For the second time add 2-4 times of water gaging, extracted 4-8 hour; Add 2-4 times of water gaging for the third time, extracted 2-6 hour; Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.10～1.20 (80 ℃), being evaporated to relative density was 1.20～1.25 (80 ℃), and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 20-40 minute, and is standby;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, the filtrate concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
Embodiment 1:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 150 parts of Radix Arnebiae (Radix Lithospermi)s.
Preparation method is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.05 (70 ℃), adding concentration was the ethanol of 93%w/w, make that to become to contain alcohol amount be 45%, 70 ℃ of insulated and stirred 20 minutes left standstill 10 hours, discarded the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20 (70 ℃), normal pressure is concentrated into the unguentum of moisture≤25%; According to unguentum: the ratio of purified water: glycerol=1000g: 800ml: 4ml adds purified water and glycerol in unguentum, stir, and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 30 minutes, promptly gets American-cockroach-extract, and is standby; Radix Arnebiae (Radix Lithospermi) is decocted with water extraction three times, add 4 times of water gagings for the first time, extracted 6 hours; For the second time add 2 times of water gagings, extracted 4 hours; Add 2 times of water gagings for the third time, extracted 2 hours; Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.10 (80 ℃), being evaporated to relative density was 1.20 (80 ℃), and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 20 minutes, and is standby; Prepared two kinds of extracts mixing is stirred, and through plate-and-frame filtration, the filtrate concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
Embodiment 2:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 200 parts of Radix Arnebiae (Radix Lithospermi)s.
Preparation method is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 500Kg water, soaks after 2 hours, and temperature is extracted three times about 78 ℃, 9 hours for the first time; For the second time add water 400Kg, extracted 7 hours; Add water 400Kg for the third time, extracted 5 hours.Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.25 (90 ℃), adding concentration was the ethanol of 97%w/w, make that to become to contain alcohol amount be 55%, 90 ℃ of insulated and stirred 40 minutes left standstill 14 hours, discarded the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.25 (90 ℃), normal pressure is concentrated into the unguentum of moisture≤35%; According to unguentum: the ratio of purified water: glycerol=1000g: 1200ml: 6ml adds purified water and glycerol in unguentum, stir, and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 30 minutes, promptly gets American-cockroach-extract, and is standby; Radix Arnebiae (Radix Lithospermi) is decocted with water extraction three times, add 6 times of water gagings for the first time, extracted 10 hours; For the second time add 4 times of water gagings, extracted 8 hours; Add 4 times of water gagings for the third time, extracted 6 hours; Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.20 (80 ℃), being evaporated to relative density was 1.25 (80 ℃), and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 40 minutes, and is standby; Prepared two kinds of extracts mixing is stirred, and through plate-and-frame filtration, the filtrate concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
Embodiment 3:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 300 parts of Radix Arnebiae (Radix Lithospermi)s.
Preparation method is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 400Kg water, soaks after 1 hour, and temperature is extracted three times about 74 ℃, 8 hours for the first time; For the second time add water 300Kg, extracted 6 hours; Add water 300Kg for the third time, extracted 4 hours.Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.15 (80 ℃), adding concentration was the ethanol of 95%w/w, make that to become to contain alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes left standstill 12 hours, discarded the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.25 (80 ℃), normal pressure is concentrated into the unguentum of moisture≤30%; According to unguentum: the ratio of purified water: glycerol=1000g: 1000ml: 5ml adds purified water and glycerol in unguentum, stir, and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 30 minutes, promptly gets American-cockroach-extract, and is standby; Radix Arnebiae (Radix Lithospermi) is decocted with water extraction three times, add 5 times of water gagings for the first time, extracted 8 hours; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.15 (80 ℃), being evaporated to relative density was 1.20 (80 ℃), and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 30 minutes, and is standby; Prepared two kinds of extracts mixing is stirred, and through plate-and-frame filtration, the filtrate concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
Embodiment 4:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 2 parts of Radix Arnebiae (Radix Lithospermi)s.
Preparation method is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 380Kg water, soaks after 0.8 hour, and temperature is extracted three times about 74 ℃, 7.5 hours for the first time; For the second time add water 280Kg, extracted 5 hours; Add water 280Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.2 (80 ℃), adding concentration was the ethanol of 95%w/w, make that to become to contain alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes left standstill 11 hours, discarded the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20 (80 ℃), normal pressure is concentrated into the unguentum of moisture≤30%; According to unguentum: the ratio of purified water: glycerol=1000g: 1100ml: 6ml adds purified water and glycerol in unguentum, stir, and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 30 minutes, promptly gets American-cockroach-extract, and is standby; Radix Arnebiae (Radix Lithospermi) is decocted with water extraction three times, add 5 times of water gagings for the first time, extracted 7 hours; For the second time add 3 times of water gagings, extracted 5 hours; Add 2 times of water gagings for the third time, extracted 2 hours; Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.10 (80 ℃), being evaporated to relative density was 1.25 (80 ℃), and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 35 minutes, and is standby; Prepared two kinds of extracts mixing is stirred, and through plate-and-frame filtration, the filtrate concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
The pharmaceutical composition of treatment diaper rash provided by the present invention can be made various ways such as tablet, suppository, capsule, is beneficial to satisfy different patients' medication custom.
The clinical testing data of diaper rash cure rate:
One, patient's classified data:
Diaper rash patient 80 examples meet diagnostic criteria.Be divided into treatment group and matched group at random, 40 examples are organized in treatment, 0.3～3 years old age; Matched group 40 examples, 0.3～3 years old age.The two groups of patient ages and the course of disease are learned processing by statistics, and difference does not have the significance meaning, has comparability.
Two, Therapeutic Method:
Treatment group: get prepared unguentum, evenly be coated with and put on the skin, every day 3 times～4 times, 1 day～5 days course of treatment in the affected skin surface according to the present invention.
Matched group: Oleum Radix Arnebiae (Oleum Radix Lithospermi) evenly is coated with and puts on the skin in the affected skin surface, every day 3 times～4 times, 1 day～5 days course of treatment.
Three, curative effect comparative result:
Table 1 is depicted as two groups of curative effects relatively, and wherein 40 examples are organized in treatment, cure 38 examples, and cure rate is 95.00%, and total effective rate is 100%; Matched group 40 examples are cured 35 examples, and cure rate is 87.50%, and total effective rate is 95.00%.Table 2 is depicted as two groups of 5 days curative effects relatively, treats in 5 days, and treatment group cure rate is 80.00%, and the matched group cure rate is 60.00%.This shows that treatment group curative effect obviously is better than matched group.(n number of delegates in table 1 and the table 2)
Table 1
Table 2
| Group | ??n | 5 days healing patient numbers | 5 days cure rates (%) |
| The treatment group | ??40 | ??32 | ?80.00 |
| Matched group | ??40 | ??24 | ?60.00 |
Four, conclusion (of pressure testing):
The generation of diaper rash is relevant with multiple factor, common has that diaper not diligently changes, do not clean after an action of the bowels, buttocks humidity, the coarse water absorption difference of diaper or the like.Oleum Radix Arnebiae (Oleum Radix Lithospermi) is a kind of medicine that is usually used in the diaper rash treatment, and certain curative effect is arranged.Periplaneta americana is a kind of insecticide, be commonly called as Blatta seu periplaneta, body contains the various active composition, and its extract main component is polyalcohols and peptide class active substance, confirm to have promotion epithelial cell, granulation tissue growth through pharmacological research, promote wound repair, the effect of enhance immunity, but do not have antibacterial action, the medicine that American-cockroach-extract and Radix Arnebiae (Radix Lithospermi) are made not only can infection, simultaneously can promote the diaper rash tissue repair, improve the diaper rash ulcer healing rate, shorten the diaper rash healing time.Comparing data shows that the curative effect that this medicine is used for the treatment of diaper rash obviously is better than medicine Oleum Radix Arnebiae (Oleum Radix Lithospermi) commonly used.
Though in conjunction with specific embodiments the specific embodiment of the present invention has been done to describe in detail, should not be construed as is limitation of the invention.In the protection domain that claims limited, various modifications that those skilled in the art can make without creative work or distortion still belong to the protection domain of this patent.
Claims (5)
1. pharmaceutical composition for the treatment of diaper rash is characterized in that: the main component of described pharmaceutical composition and mass parts thereof are such as shown in down:
100 parts of American-cockroach-extracts;
2～300 parts of Radix Arnebiae (Radix Lithospermi)s.
2. the pharmaceutical composition of treatment diaper rash according to claim 1 is characterized in that: the main component of described pharmaceutical composition and mass parts thereof are such as shown in down:
100 parts of American-cockroach-extracts;
150 parts of Radix Arnebiae (Radix Lithospermi)s.
3. the pharmaceutical composition of treatment diaper rash according to claim 1 is characterized in that: the main component of described pharmaceutical composition and mass parts thereof are such as shown in down:
100 parts of American-cockroach-extracts;
200 parts of Radix Arnebiae (Radix Lithospermi)s.
4. the preparation of drug combination method of a claim 1,2 or 3 described treatment diaper rashs, it is characterized in that: described preparation method may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: will add the water of 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Carry out the second time then behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5～7 hours; Extract for the third time behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrate;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the one-level filtrate in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that makes in step e gradually, and fully stir, making it contain the alcohol amount reaches till 45%～55%, under 70 ℃～90 ℃ temperature conditions, be incubated 20～40 minutes, left standstill then 10～14 hours, and made solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate;
H, the second time concentrate: after the secondary filtrate in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration, after filtrate is boiled 30 minutes, be chilled to room temperature, promptly get American-cockroach-extract, standby;
2., Radix Arnebiae (Radix Lithospermi) decocted with water extracts three times, add 4-6 times of water gaging for the first time, extracted 6-10 hour; For the second time add 2-4 times of water gaging, extracted 4-8 hour; Add 2-4 times of water gaging for the third time, extracted 2-6 hour; Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.10～1.20 (80 ℃), being evaporated to relative density was 1.20～1.25 (80 ℃), and through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 20-40 minute, and is standby;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, the filtrate concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
5. the preparation of drug combination method of treatment diaper rash according to claim 4 is characterized in that: amount of water is 4 times of amounts among the described step b, and soak time is 1 hour, and soaking temperature is 74 ℃.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102940589A (en) * | 2012-11-19 | 2013-02-27 | 山东华琦澳雪药物科技有限公司 | Infant hip protection gel |
| CN104435020A (en) * | 2013-09-22 | 2015-03-25 | 成都百草和济科技有限公司 | Composition for improving skin quality and application thereof |
| CN106377468A (en) * | 2016-11-30 | 2017-02-08 | 上海儿童营养中心有限公司 | Composition for preventing and treating diaper dermatitis and lipidosome and diaper ointment containing composition |
| CN109432158A (en) * | 2018-12-18 | 2019-03-08 | 沈阳药科大学 | A kind of Chinese medicine composition, its external application latex and its preparation method and application |
| CN114522194A (en) * | 2020-11-19 | 2022-05-24 | 四川好医生攀西药业有限责任公司 | Temperature-sensitive gel containing periplaneta americana extract as well as preparation method and application of temperature-sensitive gel |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940589A (en) * | 2012-11-19 | 2013-02-27 | 山东华琦澳雪药物科技有限公司 | Infant hip protection gel |
| CN104435020A (en) * | 2013-09-22 | 2015-03-25 | 成都百草和济科技有限公司 | Composition for improving skin quality and application thereof |
| CN106377468A (en) * | 2016-11-30 | 2017-02-08 | 上海儿童营养中心有限公司 | Composition for preventing and treating diaper dermatitis and lipidosome and diaper ointment containing composition |
| CN109432158A (en) * | 2018-12-18 | 2019-03-08 | 沈阳药科大学 | A kind of Chinese medicine composition, its external application latex and its preparation method and application |
| CN114522194A (en) * | 2020-11-19 | 2022-05-24 | 四川好医生攀西药业有限责任公司 | Temperature-sensitive gel containing periplaneta americana extract as well as preparation method and application of temperature-sensitive gel |
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Effective date of registration: 20200903 Address after: NO.115, section 3, Airport Road, Xichang City, Liangshan Yi Autonomous Prefecture, Sichuan Province Patentee after: SICHUAN GOODDOCTOR PANXI PHARMACEUTICAL Co.,Ltd. Address before: 15, building 88, building B, four Wei building, No. 610031 Camp Road, Sichuan, Chengdu Patentee before: Geng Funeng |