CN101829178B - Medicine composition for treating diaper rash and preparation method thereof - Google Patents
Medicine composition for treating diaper rash and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating diaper rash, which is mainly prepared by mixing 100 parts by weight of American cockroach extracts and the active components of 2-300 parts by weight of lithospermum. The preparation method of the medicine composition for treating diaper rash comprises the following steps of: extracting the American cockroach extracts, extracting the active components of the lithospermum, and then mixing the American cockroach extracts and the active components of the lithospermum into the medicine composition. The medicine composition has simple preparation method, fully exerts the functions of the American cockroach extracts, effectively improves the curative effect on diaper rash, has the advantages of convenient use and small toxic and side effect, and is a new medicament worth of being generalized.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of pharmaceutical composition of treating diaper rash and preparation method thereof.
Background technology
It is documented that periplaneta americana is the maximum insecticide of volume in the Blattidae, originates in South America; Periplaneta americana is the traditional Chinese medicines material, is used as medicine its property plug salty in the mouth with dry and bright adult; Poisonous, acid is arranged, functions such as dissipating blood stasis, removing food stagnancy, detoxifcation, diuretic, detumescence are arranged; Curing mainly infantile malnutrition, tonsillitis, health enclosed mass, carbuncle skin ulcer swells and ache and Scolopendra, venom etc.
In recent years along with science and technology constantly develops, through discovering that for many years the periplaneta americana epidermis contains sclerotin and chitin, elements such as bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium; Muscle hydrolysis 13 seed amino acids; Its alcohol extract has the obvious suppression effect to cancerous cell, and cardiovascular disease is had tangible curative effect.In addition, health storage vitamin B
1, B
2, nicotinic acid and ascorbic acid etc., lymph contain trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc.All contain ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.Clinical main application has: treat infantile malnutrition, control the carbuncle pyogenic infections from tumour or sore, control the Scolopendra wound, control innominate toxic swelling, control the worm venom.But also have periplaneta americana and medical herbs compatibility auxiliary treatment colon cancer.American-cockroach-extract can be controlled hepatitis B, and extract A T-2 preparation can cure mainly primary hepatocarcinoma, cardiovascular disease etc.
Notification number is CN 100525781C; Name is called " American-cockroach-extract, contain pharmaceutical composition of this extract and preparation method thereof " and publication number is CN1943600A; It is two with the American-cockroach-extract relevant patent documentations of applicant in application in 2006 that name is called " pharmaceutical composition and the new purposes thereof that contain periplaneta americana and ethanol extraction thereof "; It discloses the method for preparing and the part medical usage of American-cockroach-extract; In recent years, along with the further research to American-cockroach-extract, American-cockroach-extract has obtained further development in purposes pharmaceutically.
Baby's skin is very tender and lovely, if long period of soaking is in urine or airtight and moist because of diaper, buttocks regular meeting red little measles or skin occur and becomes more coarse, is called " diaper rash " or " red hip ".Causing the reason of diaper rash to have a lot, might be because a kind of new food also might be that baby's oneself urine is caused.
Along with growth in the living standard, people transfer active treatment to for the attitude of " diaper rash " by ignoring, and some have also occurred and have been used to treat the medicine of diaper rash, like the healthy and free from worry happiness of baby, the baby of Johnson & Johnson stern protection cream, tannic acid ointment etc.Yet these medicines mostly are chemicals, more or less exist ill effect for this with regard to tender and lovely infant skin.
Yet existing medicine still is difficult to fully up to expectations for the treatment diaper rash.For this reason, the invention provides a kind of new pharmaceutical composition that is used to treat diaper rash.
Summary of the invention
The objective of the invention is to: overcome above-mentioned deficiency of the prior art, a kind of pharmaceutical composition and preparation method thereof of treatment diaper rash of effective raising cure rate is provided.
The object of the invention is realized through following technical scheme: a kind of pharmaceutical composition of treating diaper rash is provided, it is characterized in that: the main component of said pharmaceutical composition and mass parts thereof are such as shown in down: 100 parts of American-cockroach-extracts; 2～300 parts of Radix Arnebiae (Radix Lithospermi)s.
The proportioning of one of preferred version of the pharmaceutical composition of above-mentioned treatment diaper rash is: 100 parts of American-cockroach-extracts; 150 parts of Radix Arnebiae (Radix Lithospermi)s.
Two proportioning of the preferred version of the pharmaceutical composition of above-mentioned treatment diaper rash is: 100 parts of American-cockroach-extracts; 200 parts of Radix Arnebiae (Radix Lithospermi)s.
The preparation of drug combination method of above-mentioned treatment diaper rash may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., the Radix Arnebiae (Radix Lithospermi) decocte with water is extracted three times, add 4-6 times of water gaging for the first time, extracted 6-10 hour; For the second time add 2-4 times of water gaging, extracted 4-8 hour; Add 2-4 times of water gaging for the third time, extracted 2-6 hour; Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.10～1.20 (80 ℃), being evaporated to relative density was 1.20～1.25 (80 ℃), through plate-and-frame filtration, after filtrating is boiled 20-40 minute, is chilled to room temperature, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, the filtrating concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
In sum; The preparation of drug combination method that is used to treat diaper rash provided by the present invention is simple, and has given full play to the effect of American-cockroach-extract, has effectively improved the curative effect to diaper rash; And easy to use, toxic and side effects is little, is a kind of new medicine that is worthy to be popularized.
The specific embodiment
Do further to specify below in conjunction with the embodiment specific embodiments of the invention:
The main component of the pharmaceutical composition of treatment diaper rash provided by the present invention and mass parts ratio thereof are: 100 parts of American-cockroach-extracts; 2～300 parts of Radix Arnebiae (Radix Lithospermi)s.
The proportioning of one of preferred version of the pharmaceutical composition of above-mentioned treatment diaper rash is: 100 parts of American-cockroach-extracts; 150 parts of Radix Arnebiae (Radix Lithospermi)s.
Two proportioning of the preferred version of the pharmaceutical composition of above-mentioned treatment diaper rash is: 100 parts of American-cockroach-extracts; 200 parts of Radix Arnebiae (Radix Lithospermi)s.
The preparation of drug combination method of above-mentioned treatment diaper rash may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
2., the Radix Arnebiae (Radix Lithospermi) decocte with water is extracted three times, add 4-6 times of water gaging for the first time, extracted 6-10 hour; For the second time add 2-4 times of water gaging, extracted 4-8 hour; Add 2-4 times of water gaging for the third time, extracted 2-6 hour; Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.10～1.20 (80 ℃), being evaporated to relative density was 1.20～1.25 (80 ℃), through plate-and-frame filtration, after filtrating is boiled 20-40 minute, is chilled to room temperature, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, the filtrating concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
Embodiment 1:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 150 parts of Radix Arnebiae (Radix Lithospermi)s.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.05 (70 ℃), adding concentration was the ethanol of 93%w/w; Make that to become to contain alcohol amount be 45%, 70 ℃ of insulated and stirred 20 minutes, left standstill 10 hours; Discard the upper strata oils and fats, fat, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.20 (70 ℃), normal pressure is concentrated into the unguentum of moisture≤25%; According to unguentum: the ratio of purified water: glycerol=1000g: 800ml: 4ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; The Radix Arnebiae (Radix Lithospermi) decocte with water is extracted three times, add 4 times of water gagings for the first time, extracted 6 hours; For the second time add 2 times of water gagings, extracted 4 hours; Add 2 times of water gagings for the third time, extracted 2 hours; Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.10 (80 ℃), being evaporated to relative density was 1.20 (80 ℃), through plate-and-frame filtration, after filtrating is boiled 20 minutes, is chilled to room temperature, subsequent use; Prepared two kinds of extracts mixing is stirred, and through plate-and-frame filtration, the filtrating concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
Embodiment 2:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 200 parts of Radix Arnebiae (Radix Lithospermi)s.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 500Kg water, soaks after 2 hours, and temperature is extracted three times about 78 ℃, 9 hours for the first time; For the second time add water 400Kg, extracted 7 hours; Add water 400Kg for the third time, extracted 5 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.25 (90 ℃); Adding concentration is the ethanol of 97%w/w, makes that to become to contain the alcohol amount be 55%, 90 ℃ of insulated and stirred 40 minutes; Left standstill 14 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.25 (90 ℃), normal pressure is concentrated into the unguentum of moisture≤35%; According to unguentum: the ratio of purified water: glycerol=1000g: 1200ml: 6ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; The Radix Arnebiae (Radix Lithospermi) decocte with water is extracted three times, add 6 times of water gagings for the first time, extracted 10 hours; For the second time add 4 times of water gagings, extracted 8 hours; Add 4 times of water gagings for the third time, extracted 6 hours; Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.20 (80 ℃), being evaporated to relative density was 1.25 (80 ℃), through plate-and-frame filtration, after filtrating is boiled 40 minutes, is chilled to room temperature, subsequent use; Prepared two kinds of extracts mixing is stirred, and through plate-and-frame filtration, the filtrating concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
Embodiment 3:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 300 parts of Radix Arnebiae (Radix Lithospermi)s.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 400Kg water, soaks after 1 hour, and temperature is extracted three times about 74 ℃, 8 hours for the first time; For the second time add water 300Kg, extracted 6 hours; Add water 300Kg for the third time, extracted 4 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.15 (80 ℃); Adding concentration is the ethanol of 95%w/w, makes that to become to contain the alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes; Left standstill 12 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.25 (80 ℃), normal pressure is concentrated into the unguentum of moisture≤30%; According to unguentum: the ratio of purified water: glycerol=1000g:1000ml:5ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; The Radix Arnebiae (Radix Lithospermi) decocte with water is extracted three times, add 5 times of water gagings for the first time, extracted 8 hours; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.15 (80 ℃), being evaporated to relative density was 1.20 (80 ℃), through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, subsequent use; Prepared two kinds of extracts mixing is stirred, and through plate-and-frame filtration, the filtrating concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
Embodiment 4:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 2 parts of Radix Arnebiae (Radix Lithospermi)s.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 380Kg water, soaks after 0.8 hour, and temperature is extracted three times about 74 ℃, 7.5 hours for the first time; For the second time add water 280Kg, extracted 5 hours; Add water 280Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.2 (80 ℃); Adding concentration is the ethanol of 95%w/w, makes that to become to contain the alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes; Left standstill 11 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.20 (80 ℃), normal pressure is concentrated into the unguentum of moisture≤30%; According to unguentum: the ratio of purified water: glycerol=1000g:1100ml:6ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; The Radix Arnebiae (Radix Lithospermi) decocte with water is extracted three times, add 5 times of water gagings for the first time, extracted 7 hours; For the second time add 3 times of water gagings, extracted 5 hours; Add 2 times of water gagings for the third time, extracted 2 hours; Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.10 (80 ℃), being evaporated to relative density was 1.25 (80 ℃), through plate-and-frame filtration, after filtrating is boiled 35 minutes, is chilled to room temperature, subsequent use; Prepared two kinds of extracts mixing is stirred, and through plate-and-frame filtration, the filtrating concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
The pharmaceutical composition of treatment diaper rash provided by the present invention can be processed various ways such as tablet, suppository, capsule, is beneficial to satisfy different patients' medication custom.
The clinical testing data of diaper rash cure rate:
One, patient's classified data:
Diaper rash patient 80 examples meet diagnostic criteria.Be divided into treatment group and matched group at random, 40 examples are organized in treatment, 0.3～3 years old age; Matched group 40 examples, 0.3～3 years old age.The two groups of patient ages and the course of disease are through statistical procedures, and difference does not have the significance meaning, has comparability.
Two, Therapeutic Method:
Treatment group: get prepared unguentum, evenly be coated with and put on the skin affected skin surface, every day 3 times～4 times, 1 day～5 days course of treatment according to the present invention.
Matched group: Oleum Radix Arnebiae (Oleum Radix Lithospermi) evenly is coated with and is put on the skin affected skin surface, every day 3 times～4 times, 1 day～5 days course of treatment.
Three, curative effect comparative result:
Table 1 is depicted as two groups of curative effects relatively, and wherein 40 examples are organized in treatment, cure 38 examples, and cure rate is 95.00%, and total effective rate is 100%; Matched group 40 examples are cured 35 examples, and cure rate is 87.50%, and total effective rate is 95.00%.Table 2 is depicted as two groups of 5 days curative effects relatively, treats in 5 days, and treatment group cure rate is 80.00%, and the matched group cure rate is 60.00%.This shows that treatment group curative effect obviously is superior to matched group.(n number of delegates in table 1 and the table 2)
Table 1
Table 2
| Group | n | 5 days healing patient numbers | 5 days cure rates (%) |
| The treatment group | 40 | 32 | ?80.00 |
| Matched group | 40 | 24 | ?60.00 |
Four, conclusion (of pressure testing):
The generation of diaper rash is relevant with multiple factor, common has diaper not diligently to change, do not clean after an action of the bowels, buttocks is moist, the coarse water absorption difference of diaper or the like.Oleum Radix Arnebiae (Oleum Radix Lithospermi) is a kind of medicine that is usually used in the diaper rash treatment, and certain curative effect is arranged.Periplaneta americana is a kind of insecticide, is commonly called as Blatta seu periplaneta, and body contains the various active composition; Its extract main component is polyalcohols and peptide class active substance, confirms to have promotion epithelial cell, granulation tissue growth through pharmacological research, promotes wound repair; The effect of enhance immunity, but do not have antibacterial action, the medicine that American-cockroach-extract and Radix Arnebiae (Radix Lithospermi) are processed not only can infection; Simultaneously can promote the diaper rash tissue repair, improve the diaper rash ulcer healing rate, shorten the diaper rash healing time.Comparing data shows, the curative effect that this medicine is used to treat diaper rash obviously is superior to medicine Oleum Radix Arnebiae (Oleum Radix Lithospermi) commonly used.
Though done to describe in detail in conjunction with the specific embodiment specific embodiments of the invention, should not be construed as is to qualification of the present invention.In the protection domain that claims limited, various modifications that those skilled in the art can make without creative work or distortion still belong to the protection domain of this patent.
Claims (4)
1. pharmaceutical composition of treating diaper rash is characterized in that: the crude drug of said pharmaceutical composition and mass parts thereof are such as shown in down:
100 parts of American-cockroach-extracts;
2～300 parts of Radix Arnebiae (Radix Lithospermi)s;
The preparation of drug combination method of said treatment diaper rash may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., the Radix Arnebiae (Radix Lithospermi) decocte with water is extracted three times, add 4-6 times of water gaging for the first time, extracted 6-10 hour; For the second time add 2-4 times of water gaging, extracted 4-8 hour; Add 2-4 times of water gaging for the third time, extracted 2-6 hour; Merge three times extracting solution, filter, it is 1.10～1.20 o'clock that filtrating is concentrated into 80 ℃ of following relative densities, and being evaporated to 80 ℃ of following relative densities is 1.20～1.25, through plate-and-frame filtration, after filtrating is boiled 20-40 minute, is chilled to room temperature, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, the filtrating concentrate drying becomes cream, is chilled to room temperature, promptly gets patent medicine.
2. the pharmaceutical composition of treatment diaper rash according to claim 1 is characterized in that: amount of water is 4 times of amounts among the said step b, and soak time is 1 hour, and soaking temperature is 74 ℃.
3. the pharmaceutical composition of treatment diaper rash according to claim 1 and 2 is characterized in that: the crude drug of said pharmaceutical composition and mass parts thereof are such as shown in down:
100 parts of American-cockroach-extracts;
150 parts of Radix Arnebiae (Radix Lithospermi)s.
4. the pharmaceutical composition of treatment diaper rash according to claim 1 and 2 is characterized in that: the crude drug of said pharmaceutical composition and mass parts thereof are such as shown in down:
100 parts of American-cockroach-extracts;
200 parts of Radix Arnebiae (Radix Lithospermi)s.
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| CN102940589A (en) * | 2012-11-19 | 2013-02-27 | 山东华琦澳雪药物科技有限公司 | Infant hip protection gel |
| CN104435020B (en) * | 2013-09-22 | 2018-04-24 | 成都百草和济科技有限公司 | A kind of composition for improving skin quality and application thereof |
| CN106377468A (en) * | 2016-11-30 | 2017-02-08 | 上海儿童营养中心有限公司 | Composition for preventing and treating diaper dermatitis and lipidosome and diaper ointment containing composition |
| CN109432158A (en) * | 2018-12-18 | 2019-03-08 | 沈阳药科大学 | A kind of Chinese medicine composition, its external application latex and its preparation method and application |
| CN114522194A (en) * | 2020-11-19 | 2022-05-24 | 四川好医生攀西药业有限责任公司 | Temperature-sensitive gel containing periplaneta americana extract as well as preparation method and application of temperature-sensitive gel |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099293A (en) * | 1994-04-05 | 1995-03-01 | 武汉市第三医院 | Ointment for prevention and cure of diaper rash of newborn |
| CN100525781C (en) * | 2006-09-30 | 2009-08-12 | 耿福能 | American falx extract, medicinal composition containing it and its making method |
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Effective date of registration: 20200903 Address after: NO.115, section 3, Airport Road, Xichang City, Liangshan Yi Autonomous Prefecture, Sichuan Province Patentee after: SICHUAN GOODDOCTOR PANXI PHARMACEUTICAL Co.,Ltd. Address before: 15, building 88, building B, four Wei building, No. 610031 Camp Road, Sichuan, Chengdu Patentee before: Geng Funeng |