CN1099293A

CN1099293A - Ointment for prevention and cure of diaper rash of newborn

Info

Publication number: CN1099293A
Application number: CN 94103633
Authority: CN
Inventors: 刘先兰
Original assignee: Wuhan No3 Hospital
Current assignee: Wuhan No3 Hospital
Priority date: 1994-04-05
Filing date: 1994-04-05
Publication date: 1995-03-01

Abstract

The ointment is indicated for prevention and treatment of infant diaper eczema, it consists of human placenta, root of arnebia euchroma, bark of corktree, coptis rhizoma, radix scutellariae, vaseline or vaseline and wool grease, and sesame oil; more than 3000 cases verified that the cure rate reaches 95.89%.

Description

Ointment for prevention and cure of diaper rash of newborn

The present invention relates to prevent and treat neonate cigarette buttocks skin ulcer is the Chinese medicine unguentum of diaper rash.

Diaper rash means that diaper hides the acute limitation dermatitis that the position takes place, and is one of neonate commonly encountered diseases, and the lighter causes the infant misery, and weight person can take place to infect and cause septicemia.Do not have desirable Therapeutic Method in the past, the conventional medicine that uses is 5% tannic acid ointment, and 1% Radix Arnebiae (Radix Lithospermi) wet goods curative effect is all not ideal enough.In order to reduce or remit the generation of infant diaper rash and complication, it is very necessary studying the new more effective medicament of preventing and treating the newborn diapers rash.

The objective of the invention is to control principle according to the dialectical opinion of Chinese medicine, develop the effect that a kind of Chinese medicine unguentum, this medicament of preventing and treating diaper rash should have heat clearing away, dehumidifying, detoxifcation, removing heat from blood, invigorate blood circulation, promote that the ulceration tissue repair is grown, had no side effect, the medicine source is easy to get cheap, practicability and effectiveness.

The cause of disease of infant diaper rash is because ewborn infant skin surface angleplied laminate is very thin, skin is tender, the skin barrier function is relatively poor, and baby's trick is stretched tight and tied up in addition, and damp and hot in the lower limb bifurcation, QI and blood is not lived, diaper hides the position and doublely is subjected to fecaluria dirt dipping, nurses inappropriately, and acute limitation dermatitis will take place.Therefore in order to realize the foregoing invention purpose, press the principle of differential diagnosis in tcm treatment damp-heat type dermatitis, select for use and have removing heat from blood, invigorate blood circulation, antibacterial, antibiotic, pain relieving, convergence antiallergic, promote the Chinese herbal medicine composition of ulceration tissue repair, as the safe and effective ointment of Placenta Hominis, Radix Arnebiae (Radix Lithospermi), Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae and accent lubrication agent vaseline, lanoline, Oleum Sesami preparation treatment diaper rash, the present invention claims ointment.

Placenta Hominis is the Placenta Hominis of healthy women, gets through clean dry, and nature and flavor are sweet, salty, warm, and it contains nitrogenous polysaccharide body and multiple antibody, and similar Stuart factor is arranged ₁₁₁Fibrin stabilizing factor plasmin unit activator; Peptone, polypeptide, choline, hormone and enzyme etc., and contain various trace elements.Have removing heat from blood, invigorate blood circulation, build up resistance and substance transportation and complex functionality, can promote wound healing, also have antihistaminic effect.

Radix Arnebiae (Radix Lithospermi) nature and flavor, bitter cold, has the effect of antibacterial, antibiotic, pain relieving convergence and short epithelial cell growth, removing heat from blood arranged, invigorate blood circulation, heat-clearing toxin-expelling functions, staphylococcus aureus, suppurative bacterium, escherichia coli, multiple fungus all there is inhibitory action, can suppress capillary permeability, so antiinflammatory action is arranged, can promote wound healing.

Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae are Chinese medicine with wide spectrum effect, cure mainly damp and hot, eczema, can remedy Placenta Hominis to the adiaphorous deficiency of endotoxemia that escherichia coli cause, the antimicrobial antiphlogistic of coordination, antianaphylactic effect are arranged.

The concrete prescription of ointment of the present invention is counted by weight:

Placenta Hominis 40-60 part

Radix Arnebiae (Radix Lithospermi) 20-30 part

Cortex Phellodendri 5-10 part

Rhizoma Coptidis 3-7.5 part

Radix Scutellariae 2.0-5 part

10 parts in vaseline

Lanoline 0-part

Oleum Sesami 0-part

Manufacture method be get fresh Placenta Hominis, cut off fetal membrane, umbilical cord, wash, smash to pieces, adding distil water boiled 15 minutes in right amount, the elimination juice is got its slag oven dry, was pulverized 120 mesh sieves.With vaseline and lanoline heat fused, add Oleum Radix Arnebiae (Oleum Radix Lithospermi), Placenta Hominis powder, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae powder, mix well and get final product, 1-2 week preparation once, medicine is fresh in guarantor's curative effect.

Embodiment 1-4 formulation example by listed Placenta Hominis, Radix Arnebiae (Radix Lithospermi), Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae and the vaseline of measuring of table 1, is produced ointment by aforementioned compound method.

Table 1

Embodiment 2, with embodiment 1-4 preparation ointment, try out in the pre-red buttock proofs of clinical 3000 examples, medicine is evenly embrocated in the skin lesion district, more changed dressings 1 time during changing babies' napkin in every 2-3 hour, the skin lesion severe patient remakes disposal with warm water cleaning earlier, sickness rate 146 examples, account for 4.87%, continue with this medicine treatment, through 2720 human therapies, the recovery from illness shortest time is 12 hours, and maximum duration is 11 days.1 group of matched group is with 5% tannic acid ointment, 125 examples, and sickness rate 19 examples account for 15.2%, and 2 groups of matched groups are with 1% Oleum Radix Arnebiae (Oleum Radix Lithospermi), 125 examples, and 25 examples of falling ill account for 20%, and through 1532 person-times of treatments, the recovery from illness shortest time is 24 hours, and maximum duration is 13 days, and prevention and therapeutic effect see Table 2.Therapeutic effect sees Table 3.

Efficacy assessment standard:

Recovery from illness treatment 2-5 days, it is normal that skin lesion recovers fully.

Take a turn for the better and treated 2-5 days, skin lesion obviously alleviates, and its scope is obviously dwindled.

Futile treatment 5 days, skin lesion do not have change or increase the weight of.

By data in the table as can be known, experimental therapy group cure rate 95.89% has 22 examples to fully recover in 5 days in average course of treatment 146 examples, and the shortest to begin the improvement time be 12 hours (4 example), and the fastest treatment time is one day (2 example).

Table 2 liang group morbidity, the course of treatment, Comparison of therapeutic

Group is prevented routine number	Calibration	Send out case load	Sickness rate %	The treatment person-time	Average course of treatment (my god)	Therapy	Effective routine number	％
									Experimental group 300	Ⅰ Ⅱ Ⅲ	92 30 24	63.1 20.5 16.4	900 600 1200	1-3 2-5 4-9	Ointment+the electrotherapy of ointment ointment	92 30 23	100 100 95.33
Contrast 1 group 125	Ⅰ Ⅱ Ⅲ	10 5 4	22.72 11.4 9.1	180 120 240	1-4 3-7 5-11	Tannic acid ointment+the electrotherapy of tannic acid ointment tannic acid ointment	9 4 3	90 80 75
									Contrast 2 group 125	Ⅰ Ⅱ Ⅲ	11 6 8	25 13.6 18.2	254 210 528	2-5 4-8 6-13	Oleum Radix Arnebiae (Oleum Radix Lithospermi)+the electrotherapy of Oleum Radix Arnebiae (Oleum Radix Lithospermi) Oleum Radix Arnebiae (Oleum Radix Lithospermi)	10 5 5	91 83.3 62.5

Contrast 1,2 group of total incidence I degree=47.7% II degree=25% III degree=87.3%

1 group of cure rate 68.42% of contrast treatment, the contrast treatment is 52% for 2 groups, 32 examples is arranged recovery from illness in 7-8 days in average course of treatment 44 examples, and it is the shortest that to begin the improvement time be 24 hours (2 example), and controlling the time of fullying recover from an illness the soonest is 2 days (2 example).

Toxicity does not take place at the treatment viewing duration in two groups of cases.The experimental group sickness rate is 4.87%, and the matched group sickness rate is 17.6%, learn by statistics and handle, and X 2 test, there were significant differences for two groups of prevalences, X ²=68.25, P＜0.01.

Experimental therapy group cure rate is 95.89%, and matched group is 59.10%, learn to handle, X 2 test two groups of cure rates there were significant differences X by statistics ²=43, P＜0.01.

Annotate 1: the skin lesion calibration, be divided into three degree,

The I degree: skin lesion limitation femoribus internus, genitals, buttocks tip, scope is little, and skin lesion is light, performance macule or pimple.

The II degree: above skin lesion expanded range, to spread to big nympha, scrotum, buttocks, skin lesion heavier, except that maculopapule, changes such as impetigo, rotten material arranged.

The III degree: the skin lesion scope obviously enlarges, even spreads to big leg outer side to two ischial tuberosity place, and damaged skin exposes scarlet muscle, and skin lesion is serious, sepage occurs, oozing of blood and ulcer.

Annotate 2: case is selected, experimental therapy group 146 examples, boy baby's 95 examples, girl baby's 51 examples.Diaper rash I degree 92 examples, II degree 30 examples, III degree 24 examples.44 examples are organized in the contrast treatment, boy baby's 26 examples, and girl baby's 18 examples, it contrasts 1 group of diaper rash I degree 10 example, II degree 5 examples, III degree 4 examples contrast 2 groups of I degree 11 examples, II degree 6 examples, III degree 8 examples.

Claims

1, a kind of ointment of preventing and treating the newborn diapers rash is characterized in that forming and counts Placenta Hominis 40-60 part by weight, Radix Arnebiae (Radix Lithospermi) 20-30 part, Cortex Phellodendri 5-10 part, Rhizoma Coptidis 3-7.5 part, Radix Scutellariae 2.0-5 part, 10 parts in vaseline, lanoline 0-2 part, Oleum Sesami 0-2 part.

2, the method for the described ointment of system claim 1 is characterized in that getting fresh Placenta Hominis, cleans and smashs to pieces, oven dry, crushing screening with vaseline or vaseline and lanoline heat fused, adds Oleum Radix Arnebiae (Oleum Radix Lithospermi) in proportion, the Placenta Hominis powder, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae powder are mixed well and are got final product.