CN1686492A - Antibicrobial anti inflammatory capsule and its preparation method - Google Patents
Antibicrobial anti inflammatory capsule and its preparation method Download PDFInfo
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- CN1686492A CN1686492A CN 200510200229 CN200510200229A CN1686492A CN 1686492 A CN1686492 A CN 1686492A CN 200510200229 CN200510200229 CN 200510200229 CN 200510200229 A CN200510200229 A CN 200510200229A CN 1686492 A CN1686492 A CN 1686492A
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- 239000002775 capsule Substances 0.000 title claims abstract description 7
- 238000002360 preparation method Methods 0.000 title claims description 5
- 230000003110 anti-inflammatory effect Effects 0.000 title claims description 3
- 239000003814 drug Substances 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 241000233838 Commelina Species 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 abstract description 7
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 208000037976 chronic inflammation Diseases 0.000 abstract description 2
- 230000006020 chronic inflammation Effects 0.000 abstract description 2
- 241000155182 Monochasma Species 0.000 abstract 1
- 241000157511 Oldenlandia Species 0.000 abstract 1
- 208000038016 acute inflammation Diseases 0.000 abstract 1
- 230000006022 acute inflammation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 10
- 231100000614 poison Toxicity 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- 208000035473 Communicable disease Diseases 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A antibacterial inflammation-relieving capsule for treating acute or chronic inflammation is prepared proportionally from savatier monochasma herb, oldenlandia and doyflower herb.
Description
Technical field:
The present invention relates to a kind of heat-clearing and toxic substances removing that has, pharmaceutical preparation of anti-inflammtory anti-dysentery effect and preparation method thereof.
Technical background:
The infectious disease serious threat people's life and health.Treatment for infectious disease mainly is the application of various antibiotics at present, but the Resistant strain that multiple reason causes constantly increases, and makes antibiotic curative effect constantly descend, and the infectious disease sickness rate rises, and the treatment difficulty strengthens.Therefore, seeking a kind of safe, anti-inflammation class medicine efficiently, is a great problem that medical circle faces.
Motherland's Chinese medicine has the incomparable advantage of Western medicine in this respect, and a large amount of heat-clearing and toxic substances removing is arranged in the Chinese medicine, and antibacterial and anti-inflammation functions has fully obtained modern pharmacology and experimental results show that.In the existing anti-inflammation class Chinese medicine, " scorching peaceful granule " is more a kind of, but because its dosage form and technologic defective in use also exist and take effect slowly, takes problems such as inconvenience.
Summary of the invention:
The objective of the invention is to: provide a kind of and on former medicine basis, change original technology, its extraction ratio of effective constituents is increased greatly, can better increase its clinical efficacy, to overcome the deficiency of existing medicine.
The present invention is achieved in that it is mainly made by following Chinese medicine raw materials by weight proportion in 1000 dosage units: 2000～5000 parts of Herba monochasmatiss, 1000～3000 parts of Herba Hedyotidis Diffusaes, 1000～3000 parts of Herba Commelinaes.
Wherein the consumption of crude drug is: 3906 parts of Herba monochasmatiss, 1953 parts of Herba Hedyotidis Diffusaes, 1953 parts of Herba Commelinaes.
Wherein also be added with adjuvant lubricant 0.2-1 part.
Described lubricant is magnesium stearate or micropowder silica gel, preferred micropowder silica gel.
Its preparation method is: above three flavors, decoct with water secondary, and add 10 times of water gagings for the first time, soak 30min, decocted 1.5 hours, and added 8 times of water gagings for the second time, decocted collecting decoction 1.0 hours, filter, filtrate is concentrated into relative density 1.10 (85～90 ℃), adds ethanol and makes that to contain the alcohol amount be 60%, stirs evenly, left standstill 12 hours, and filtered, filtrate is concentrated into the clear paste that relative density is 1.32 (85～90 ℃), drying, pulverize, granulate drying, granulate, add lubricant, fill, promptly.
The present invention compared with prior art has good effect, advantages such as taking convenience.Compare with Western medicine, the present invention have antibiotic extensively, overcome the Western medicine drug resistance, thoroughly kill bacteria virus, diminish inflammation; Effect is rapid, curative effect is high, generally take and took effect the same day, 3? it cures (acute); The sterilization sterilization thoroughly improves leukocytes phagocytic power, the radical cure active chronic inflammation; Pure Chinese medicine extraction, the characteristics that have no side effect.
Below beneficial effect by pharmacological evaluation explanation medicine of the present invention:
In order to verify that the present invention has antibacterial and anti-inflammation functions, the clinical experiment of having organized 100 people to participate in, wherein male 68 examples, women 32 examples; Age 1-15 year person's 36 examples, 16-35 year person's 42 examples, 36-50 year person's 16 examples, person's 6 examples more than 50 years old; The course of disease three days with interior person's 66 examples, a week, January was with interior person's 4 examples with interior person's 8 examples in ten days with interior person's 22 examples.
During treating, give 4/time, 3 times/day.Take month surplusly continuously, treatment back clinical symptoms all disappears, and stool routine examination transfers to normally, and the body temperature blood examination is normal and observe and follow up a case by regular visits to the person of not sending out a week and be healing.This group took 5 days and more person's 32 examples account for 32%.Took 7 days and more person's 42 examples account for 42%.Took 15 days and more person's 17 examples account for 17%.Took 30 days and more person's 9 examples account for 9%.Cure rate is 100%.
Wherein Herba monochasmatis acrid in the mouth hardship in the side is warm in nature.Expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation.Control traumatic injury, rheumatic arthritis, hepatitis, jaundice.Cold in nature, the sweet-bitter flavor of Herba Hedyotidis Diffusae, GUIXIN, lung, liver, large intestine channel have the effect of heat-clearing and toxic substances removing, convergence dampness removing, eliminating carbuncle eliminating stagnation.Modern pharmacological research confirms that Herba Hedyotidis Diffusae has the effect of anti-inflammation, antitumor, antiviral, raise immunity.Herba Commelinae is sweet, light, and is cold.Return lung, stomach, small intestine meridian.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.Be used for anemopyretic cold, hyperpyrexia, laryngopharynx swelling and pain, edema oliguria, the puckery pain of pyretic stranguria, carbuncle furunculosis.Three's prescription mutual reinforcement between mutual-assistance to the treatment respiratory tract infection, tonsillitis, diseases such as urinary tract infection have effect preferably.
The specific embodiment:
Embodiments of the invention: take by weighing deer Roripa grass 39068; Herba Hedyotidis Diffusae 1953g, Herba Commelinae 1953g decoct with water secondary, add 10 times of water gagings for the first time, soak 30min, decoct 1.5 hours, for the second time add 8 times of water gagings, decocted 1.0 hours, collecting decoction filters, filtrate is concentrated into relative density 1.10 (85～90 ℃), adds ethanol and makes that to contain alcohol amount be 60%, stirs evenly, and leaves standstill 12 hours, filter, filtrate is concentrated into the clear paste that relative density is 1.32 (85～90 ℃), and drying is pulverized, granulate drying, granulate, add micropowder silica gel 4.0g, fill, promptly get 1000.
Claims (5)
1. Antibicrobial anti inflammatory capsule, it is characterized in that: in 1000 dosage units, it is mainly made by following Chinese medicine raw materials by weight proportion: 2000～5000 parts of Herba monochasmatiss, 1000～3000 parts of Herba Hedyotidis Diffusaes, 1000～3000 parts of Herba Commelinaes.
2. capsule according to claim 1 is characterized in that: wherein the consumption of crude drug is: 3906 parts of Herba monochasmatiss, 1953 parts of Herba Hedyotidis Diffusaes, 1953 parts of Herba Commelinaes.
3. capsule according to claim 1 and 2 is characterized in that: wherein also be added with adjuvant lubricant 0.2-1 part.
4. capsule according to claim 3 is characterized in that: described lubricant is magnesium stearate or micropowder silica gel, preferred micropowder silica gel.
5. capsular according to claim 1 preparation method is characterized in that: above three flavors decoct with water secondary, add for the first time 10 times of water gagings, soak 30min, decocted 1.5 hours, for the second time add 8 times of water gagings, decocted collecting decoction 1.0 hours, filter, filtrate is concentrated into relative density 1.10 (85～90 ℃), adds ethanol and makes that to contain the alcohol amount be 60%, stir evenly, left standstill 12 hours, and filtered, filtrate is concentrated into the clear paste that relative density is 1.32 (85～90 ℃), dry, pulverize, granulate drying, granulate, add lubricant, fill, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510200229 CN1686492A (en) | 2005-04-11 | 2005-04-11 | Antibicrobial anti inflammatory capsule and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510200229 CN1686492A (en) | 2005-04-11 | 2005-04-11 | Antibicrobial anti inflammatory capsule and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1686492A true CN1686492A (en) | 2005-10-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510200229 Pending CN1686492A (en) | 2005-04-11 | 2005-04-11 | Antibicrobial anti inflammatory capsule and its preparation method |
Country Status (1)
| Country | Link |
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| CN (1) | CN1686492A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258615A (en) * | 2011-06-25 | 2011-11-30 | 哈药集团三精千鹤制药有限公司 | Yanning capsule and preparation method thereof |
| CN102335272A (en) * | 2011-09-28 | 2012-02-01 | 哈尔滨市康隆药业有限责任公司 | Liquid preparation for diminishing inflammation and preparation method thereof |
| CN102488779A (en) * | 2011-12-31 | 2012-06-13 | 苏州大学 | Application of extract of Antlerpilose grass |
| CN110787104A (en) * | 2018-08-20 | 2020-02-14 | 惠州市九惠制药股份有限公司 | Compound traditional Chinese medicine toothpaste and preparation method and application thereof |
-
2005
- 2005-04-11 CN CN 200510200229 patent/CN1686492A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258615A (en) * | 2011-06-25 | 2011-11-30 | 哈药集团三精千鹤制药有限公司 | Yanning capsule and preparation method thereof |
| CN102335272A (en) * | 2011-09-28 | 2012-02-01 | 哈尔滨市康隆药业有限责任公司 | Liquid preparation for diminishing inflammation and preparation method thereof |
| CN102335272B (en) * | 2011-09-28 | 2013-09-04 | 哈尔滨市康隆药业有限责任公司 | Liquid preparation for diminishing inflammation and preparation method thereof |
| CN102488779A (en) * | 2011-12-31 | 2012-06-13 | 苏州大学 | Application of extract of Antlerpilose grass |
| CN102488779B (en) * | 2011-12-31 | 2014-02-26 | 苏州大学 | Application of velvet extract |
| CN110787104A (en) * | 2018-08-20 | 2020-02-14 | 惠州市九惠制药股份有限公司 | Compound traditional Chinese medicine toothpaste and preparation method and application thereof |
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