CN102335272A - Liquid preparation for diminishing inflammation and preparation method thereof - Google Patents
Liquid preparation for diminishing inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicine for resisting bacteria and diminishing inflammation, and a liquid preparation for diminishing inflammation. A Chinese medicinal composition comprises the following Chinese herbal materials in part by weight: 1,500 to 1,568 parts of herb of savatier monochasma, 745 to 788 parts of commelina communis, and 745 to 788 parts of hedyotis diffusa. The liquid preparation for diminishing inflammation is an oral medicinal preparation which does not contain medicinal excipients or an oral medicinal preparation containing sucrose or sweetener, preferably the liquid preparation is oral liquid or syrup. The composition is a pure Chinese medicinal preparation; compared with the common antibiotic medicine, the composition has the advantages that the composition has small side effects and a human body does not have medicine resistance after taking the composition for a long time; the preparation for diminishing inflammation is the liquid preparation (the oral liquid or syrup); and compared with the common Chinese medicine for diminishing inflammation, the composition can be absorbed easily by a human body, has quick response, is easy to take and wide in an application range.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and Chinese medicine preparation, particularly relate to a kind of Chinese medicine composition that is used for anti-inflammation and anti-inflammation formulation and preparation method thereof.
Background technology
Existing antibiotic medicine antibiotics is in the majority, and the antibiotics product is internal and international repeats injunctions, and bans use of, and this quasi drugs life-time service is prone to make people's body immunity to descend, and makes human body produce drug resistance, and is very big to the human injury.Pure Chinese medicinal preparation antibiotic medicine with antiinflammation all is oral solid formulations; Like tablet, capsule and granule; The infiltration rate of this solid preparation of Chinese medicine and onset are all slower; And it is harmful and do not have profit to people's health in the preparation process, will to add certain adjuvant, and above-mentioned medicine all can not well be fit to clinical requirement.
Number of patent application is 200710092965.8 one Chinese patent application, and open day is 2008.4.30, discloses " a kind of Laryngalgia anti-inflammation Chinese medicine preparation that improves taste and preparation method thereof "; It is the process modification that existing Chinese patent medicine Laryngalgia anti-inflammation ball is carried out; Solved the lasting bitter to the taste numb tongue flavor that causes because of the Venenum Bufonis medical material, laryngalgia has been had certain alleviation and healing effect, but because said preparation preferred tablet form; Infiltration rate is slower; The course of treatment is longer, and contains the adjuvant of non-Chinese medicine ingredients in this Chinese medicine preparation, the people is known from experience cause certain harm.
Number of patent application is 200810151354.0 one Chinese patent application; Open day is 2009.2.11; Disclose " a kind of anticoccidial, hemostasis are enriched blood, anti-inflammation Chinese medicine composition and preparation method thereof "; Its main component is arteannuin and halofuginone hydrobromide, and this Chinese medicine preparation is a granule, mainly is applicable to animal body.
Patent announcement number is the patent of CN1159043C, discloses a kind of " dephlogisticate Chinese medicine oral liquid ", is processed by natural Chinese medicines such as Folium Isatidis, Fructus Forsythiae, Flos Lonicerae, Radix Bupleuri; Has the effect of bringing down a fever with antiinflammatory; Have no side effect, this Chinese medicine preparation is an oral liquid, and human body has absorption preferably; But this Chinese medicine oral liquid mainly is applicable to the hyperpyrexia that cold, fever causes; The effect of bringing down a fever obviously has assist in treating for the inflammation that is caused by fever, does not see that for the inflammation that other reasons causes the therapeutic effect of this respect verification experimental verification is arranged.
Summary of the invention
The pure Chinese medicine composition that the technical problem that the present invention will solve provides a kind of taking convenience, is easy to absorption of human body, instant effect, antiinflammatory are effective, pure Chinese medicine anti-inflammation formulation and preparation method thereof.
For reaching above-mentioned purpose, anti-inflammatory medicine compositions of the present invention contains following parts by weight of Chinese traditional medicine raw material: Herba monochasmatis 1500-1568, Herba Commelinae 745-788, Herba Hedyotidis Diffusae 745-788.
Wherein the weight portion of each raw material of Chinese medicine is preferred: Herba monochasmatis 1550-1566, Herba Commelinae 750-785, Herba Hedyotidis Diffusae 750-785.More preferably: Herba monochasmatis 1562.5, Herba Commelinae 781.25, Herba Hedyotidis Diffusae 781.25.
The scorching peaceful liquid preparation of the present invention for not containing the oral drug preparation form of medicinal adjuvant, or contains the oral drug preparation form of sucrose or sweeting agent.Preferred said preparation is oral liquid or syrup.
The scorching peaceful liquid preparation of the present invention when its preparation is syrup, is divided into sugared type syrup and Sugarless type syrup is arranged, and it is 600-650 that the weight portion that sucrose adds in the sugared type syrup is arranged, and the weight portion of the interpolation of sweeting agent described in the Sugarless type syrup is 0.5-5.
The present invention prepares the method for the peaceful liquid preparation of above-mentioned inflammation, takes by weighing each raw medicinal material respectively by above-mentioned said proportioning, with raw medicinal material decocte with water twice, for the first time amount of water be medical material weight 6-15 doubly; For the second time amount of water be medical material weight 5-12 doubly, decocted 1.5 hours for the first time, decocted 1 hour for the second time; Collecting decoction filters and discards medicinal residues, and it is 1.0-1.10 (using the gravity Baume instrumentation for 80 ℃) that filtrating is concentrated into density; Add ethanol, make to contain the alcohol amount in the filtrating to reach parts by weight be 50%-60%, stir; Left standstill 10-14 hour, and filtered alcoholic solution, the ethanol in the filtrating is reclaimed; Last solution is the aqueous solution that does not contain alcohol, and will removing alcoholic acid filtrating continuation, to be concentrated into density be 1.10-1.20 (using the gravity Baume instrumentation for 80 ℃), and it is subsequent use to make extract;
Get the sucrose heating for dissolving of above-mentioned weight portion, add said extracted thing and antiseptic then, heated and boiled keeps little and boiled 20 minutes, is cooled to below 60 ℃, is settled to scale, continues to be cooled to 45-55 ℃, and packing has promptly got sugared type syrup; Perhaps, get the said extracted thing and be heated to 55-65 ℃, add the sweeting agent and the antiseptic heated and boiled of above-mentioned weight portion then, keep little and boiled 20 minutes, be cooled to below 60 ℃, be settled to scale, continue to be cooled to 45-55 ℃, packing promptly gets the Sugarless type syrup; Perhaps, get the said extracted thing and add an amount of purified water heating dilution, add flavoring agent and antiseptic heated and boiled then, keep little and boiled 20 minutes, cooling is settled to scale below 60 ℃, continues to be cooled to 45-55 ℃, and packing promptly gets oral liquid formulations.
The present invention prepares in the method for scorching peaceful liquid preparation, and used sweeting agent is cyclamate, steviosin, acesulfame potassium, sucralose, alitame, novel compound sweeting agent, protein sugar, xylitol, dichloro chalcone derivative, oligosaccharide, erithritol, glycyrrhizin, Fructus Momordicae extracting solution or thaumati etc.
The present invention prepares in the method for scorching peaceful liquid preparation, and used antiseptic is sodium benzoate or potassium sorbate, and addition accounts for 0.25% (mass volume ratio, the addition of antiseptic is 0.25g in the scorching peaceful preparation of promptly every 100ml) of scorching peaceful preparation total amount.
The present invention prepares in the method for scorching peaceful liquid preparation; Used flavoring agent is essence and citric acid; Addition accounts for 0.03% (volume ratio of scorching peaceful preparation total amount respectively; Be the essence that contains 0.03ml in the scorching peaceful preparation of 100ml) and 0.05% (mass volume ratio, the addition of citric acid is 0.05g in the scorching peaceful preparation of promptly every 100ml).
The used raw medicinal material of the present invention all can be bought from common Chinese material shop and obtain, and its specification meets national Chinese crude drug standard and gets final product.Used sweeting agent, flavoring agent and the antiseptic of the present invention also can have been bought from market, and it meets state food, the drug safety standard gets final product.
The application of Chinese medicine composition of the present invention in the preparation anti-inflammation drugs can be used for preparing inflammation medicines such as upper respiratory tract infection resistant, tonsillitis, urinary tract infection, acute bacillary dysentery and enteritis.
Anti-inflammatory medicine compositions difference from prior art of the present invention is that the present composition is a pure Chinese medicinal preparation, compares with antibiotic medicine commonly used, and few side effects is taken for a long time and can not be made human body generation drug resistance; The peaceful preparation of preparation of the present invention-inflammation is liquid preparation (oral liquid or syrup), compares with Chinese medicine antibiotic medicine commonly used, is more conducive to absorption of human body, and is rapid-action, taking convenience, and it is wide to be suitable for the crowd, is specially adapted to old man and children taking.
To anti-inflammatory medicine compositions of the present invention, scorching peaceful liquid preparation and preparation method thereof is described further below in conjunction with specific embodiment.
The specific embodiment
Below in conjunction with embodiment and test data, do more detailed explanation with other technical characterictic and advantage to the present invention is above-mentioned.
Embodiment 1
Take by weighing following raw material respectively:
Herba monochasmatis 1562.5g, Herba Commelinae 781.25g, Herba Hedyotidis Diffusae 781.25g, sucrose 650g, sweeting agent 2g.
With raw medicinal material decocte with water twice, for the first time amount of water is 15 times of medical material weight, and promptly amount of water is 46.9kg, and amount of water is 12 times of medical material weight for the second time; Be that amount of water is 37.5kg, decocted 1.5 hours for the first time, decocted collecting decoction 1 hour for the second time; Filtration discards medicinal residues, and it is 1.10 (using the gravity Baume instrumentation for 80 ℃) that filtrating is concentrated into density, adds ethanol, makes to contain the alcohol amount in the filtrating to reach parts by weight be 60%; Stir, left standstill 12 hours, filter; Reclaim the ethanol in the filtrating, will not containing alcoholic acid filtrating continuation, to be concentrated into density be 1.20 (using the gravity Baume instrumentation for 80 ℃), and it is subsequent use to make extract;
Getting above-mentioned weight is the sucrose heating for dissolving of 650g, adds said extracted thing and sodium benzoate 2.5g then, and heated and boiled keeps little and boiled 20 minutes, and cooling is settled to 1000ml below 60 ℃, continues to be cooled to about 50 degree, and packing has promptly got sugared type syrup.
Present embodiment also can make the Sugarless type syrup, gets the said extracted thing and is heated to about 60 degree sweeting agent and antiseptic 2.5g that to add above-mentioned load weighted weight then be 2g; Heated and boiled; Keep little and boiled 20 minutes, cooling is filtered and is settled to 1000ml below 60 ℃; Continue to be cooled to about 50 degree, packing promptly gets the Sugarless type syrup.
Present embodiment also can make the oral solutions that does not add sucrose and any sweeting agent, gets the said extracted thing and adds an amount of purified water, and the addition of pure water is about 60% of the above-mentioned extract weight that makes; The heating dilution adds 0.3ml essence, 0.5g citric acid and 2.5g sodium benzoate, heated and boiled then; Keep little and boiled 20 minutes, cooling is filtered and is settled to 1000ml below 60 ℃; Continue to be cooled to about 50 degree, packing promptly gets oral liquid formulations.
Embodiment 2
Take by weighing following raw material respectively:
Herba monochasmatis 1500g, Herba Commelinae 745g, Herba Hedyotidis Diffusae 745g, sucrose 600g, sweeting agent 0.5g.
With raw medicinal material decocte with water twice, for the first time amount of water is 6 times of medical material weight, and promptly amount of water is 17.9kg, and amount of water is 5 times of medical material weight for the second time; Be that amount of water is 14.95kg, decocted 1.5 hours for the first time, decocted collecting decoction 1 hour for the second time; Filtration discards medicinal residues, and it is 1.0 (using the gravity Baume instrumentation for 80 ℃) that filtrating is concentrated into density, adds ethanol, makes to contain the alcohol amount in the filtrating to reach parts by weight be 50%; Stir, left standstill 10 hours, filter; Reclaim the ethanol in the filtrating, will not containing alcoholic acid filtrating continuation, to be concentrated into density be 1.10 (using the gravity Baume instrumentation for 80 ℃), and it is subsequent use to make extract;
Getting above-mentioned weight is the sucrose heating for dissolving of 600g, adds said extracted thing and potassium sorbate 2.5g then, and heated and boiled keeps little and boiled 20 minutes, and cooling is filtered below 60 ℃, is settled to 1000ml, continues to be cooled to 45 ℃, and packing has promptly got sugared type syrup.
Present embodiment also can make the Sugarless type syrup, gets the said extracted thing and is heated to 55 ℃, sweeting agent and potassium sorbate 2.5g that to add above-mentioned load weighted weight then be 2g; Heated and boiled; Keep little and boiled 20 minutes, cooling is filtered below 60 ℃, is settled to 1000ml; Continue to be cooled to 45 ℃, packing promptly gets the Sugarless type syrup.
Present embodiment also can make the oral solutions that does not add sucrose and any sweeting agent, gets the said extracted thing and adds an amount of purified water, and the addition of pure water is 60% of the above-mentioned extract weight that makes; The heating dilution adds 0.3ml essence, 0.5g citric acid and 2.5g potassium sorbate, heated and boiled then; Keep little and boiled 20 minutes, cooling is filtered below 60 ℃, is settled to 1000ml; Continue to be cooled to 45 ℃, packing promptly gets oral liquid formulations.
Embodiment 3
Take by weighing following raw material respectively:
Herba monochasmatis 1568g, Herba Commelinae 788g, Herba Hedyotidis Diffusae 788g, sucrose 630g, sweeting agent 3.0g.
With raw medicinal material decocte with water twice, for the first time amount of water is 10 times of medical material weight, and promptly amount of water is 31.5kg, and amount of water is 8 times of medical material weight for the second time; Be that amount of water is 25.2kg, decocted 1.5 hours for the first time, decocted collecting decoction 1 hour for the second time; Filtration discards medicinal residues, and it is 1.15 that filtrating is concentrated into density, adds ethanol, makes to contain the alcohol amount in the filtrating to reach parts by weight be 55%; Stir, left standstill 14 hours, filter; Reclaim the ethanol in the filtrating, will not containing alcoholic acid filtrating continuation, to be concentrated into density be 1.15, and it is subsequent use to make extract;
Getting above-mentioned weight is the sucrose heating for dissolving of 630g, adds said extracted thing and 2.5g antiseptic then, and heated and boiled keeps little and boiled 20 minutes, and cooling is settled to 1000ml, continues to be cooled to 55 ℃, and packing has promptly got sugared type syrup.
Present embodiment also can make the Sugarless type syrup, gets the said extracted thing and is heated to 65 ℃, sweeting agent and 2.5g antiseptic that to add above-mentioned load weighted weight then be 3g; Heated and boiled keeps little and boiled 20 minutes, and cooling is settled to 1000ml; Continue to be cooled to 55 ℃, packing promptly gets the Sugarless type syrup.
Present embodiment also can make the oral solutions that does not add sucrose and any sweeting agent, gets the said extracted thing and adds an amount of purified water, and the addition of pure water is 60% of the above-mentioned extract weight that makes; The heating dilution adds 0.8g flavoring agent and 2.5g antiseptic, heated and boiled then; Keep little and boiled 20 minutes, cooling is filtered below 60 ℃, is settled to 1000ml; Continue to be cooled to 55 ℃, packing promptly gets oral liquid formulations.
In other embodiments; Can also take by weighing the raw material of Chinese medicine of following weight: Herba monochasmatis 1550g, Herba Commelinae 750g, Herba Hedyotidis Diffusae 750g or Herba monochasmatis 1566g, Herba Commelinae 785g, Herba Hedyotidis Diffusae 785g, described in the method for preparing of anti-inflammation formulation such as the above-mentioned embodiment.
Used sweeting agent can be this areas such as cyclamate, stevioside, acesulfame potassium, sucralose, alitame, novel compound sweeting agent, protein sugar, xylitol, dichloro chalcone derivative, oligosaccharide, erithritol, glycyrrhizin, Fructus Momordicae extracting solution or thaumati sweeting agents commonly used in the foregoing description.
Used antiseptic can also be this areas such as benzoic acid and salt, potassium sorbate, dehydro sodium acetate, propyl p-hydroxybenzoate, calcium propionate, sodium diacetate, sodium lactate, streptococcus acidi lactici, natamycin antiseptic commonly used in the foregoing description.The addition of antiseptic is 0.25% of a scorching peaceful total formulation weight amount.
Used flavoring agent can also be this areas such as citric acid, lactic acid, malic acid, flavoring pineapple essence flavoring agents commonly used in the foregoing description.The interpolation total amount of flavoring agent is the 0.07-0.09% of scorching peaceful liquid preparation gross weight.
Test Example 1: anti-inflammatory medicine compositions of the present invention is to tonsillitic therapeutic effect.
This test is divided into two groups: treatment group and matched group.
Case is selected: Western medicine diagnose is with reference to Ministry of Public Health regulation " Clinical Researches of New Drugs guideline ".Tcm diagnosis and dialectical standard are all formulated with reference to high hospital school teaching material " Chinese Internal Medicine " (five editions teaching materials) and " Clinical Researches of New Drugs guideline ".
214 routine acute tonsillitis patients are divided into two groups at random, treatment group 112 example and matched group 102 examples, two groups of patients' sex, age, antiadoncus degree distribution situation are seen table 1.
Table 1 liang group sex, age, antiadoncus degree distribution situation
Use x
2Or the t check, two groups of patient's sexes, age and state of an illness distribution there was no significant differences (P＜0.05) have comparability.
The scorching peaceful preparation that the treatment group selects for use the foregoing description to obtain, each 10ml, every day 3-4 time, one after each meal.Matched group adopts penicillin 800,000 intramuscular injection, every day 3 times.
Observation item and index: (1) main observed content: tonsillitic symptom comprises hyperpyrexia, pharyngalgia, odynophagia, submandibular lymph nodes enlargement etc.(2) inflammation classification: tonsillitis is divided into acute tonsillitis and chronic tonsillitis.(3) division of severity extent: slight: pharyngeal hypodynia, tonsil is little swollen, can take food but pain when taking food; Moderate: pharyngeal pain, congested antiadoncus can advance a small amount of liquid food, and there are point-like or lamellar purulent exudate in the tonsil surface; Severe: pharyngeal obvious congested pain, the serious enlargement of tonsil can not be taken food, and yellow lamellar secretions is arranged, be prone to wipe, and head, general pain are had a high fever, simultaneously with symptoms such as abdominal distention, constipation, short urination are red.
Efficacy assessment standard: formulate with reference to " new Chinese medicine clinical research guideline ".Clinic control: after the medication in 3 hours pharyngeal pain, hyperemia and antiadoncus obviously disappear, tonsil surface point-like or lamellar purulent exudate disappear, can take food the same day; Produce effects: after the medication in 6 hours antiadoncus obviously disappear, pharyngeal little pain or uncomfortable that has, can advance a small amount of liquid food the same day; Invalid: pharyngeal still pain, hyperemia in the medication 24 hours, can not take food.
The result: two groups of curative effects are relatively seen table 2.
Two groups of curative effects of table 2 treatment group and matched group relatively
Invalid 2 examples were cured in two days in the treatment group, cure rate 100%; 51 examples that matched group is invalid continue medication and still had 36 examples to fail to cure cure rate 64.7% in 3 days.
Analyze with Radit, R (treatment group) R2 (matched group) explains that treatment group treatment tonsillitis effect is superior to matched group, carries out the U inspection to the R value, and two groups of curative effects have significant difference (P＜0.05).
Test Example 2, the scorching peaceful preparation of anti-inflammatory medicine preparation of compositions of the present invention is injected influence/x ± s that carrageenin causes inflammatory swelling, n=8 to rat paw.The result sees table 3.
The scorching peaceful liquid preparation of table 3 anti-inflammatory medicine preparation of compositions of the present invention causes the influence of inflammatory swelling to rat paw injection carrageenin
Annotate: check, compare with the normal saline group,
* 1P＜0.05,
* 2P＜0.01,
* 3P＜0.001
This experiment adopts carrageenin to cause acute inflammation scale-model investigation antiinflammatory actions such as rat toes inflammatory swelling, and the result all has tangible antiinflammatory and refrigeration function to above-mentioned laboratory animal.
Therefore, anti-inflammatory medicine compositions of the present invention and the anti-inflammation formulation for preparing thus have good antiinflammatory curative effect; Compare with antibiotic medicine commonly used, few side effects, evident in efficacy; Chinese medicine composition of the present invention is pure Chinese medicine ingredients; Scorching peaceful liquid preparation is the anti-inflammation formulation of pure Chinese medicine, does not contain other chemical antiinflammatory composition, takes for a long time to make human body produce drug resistance; The scorching peaceful preparation of the present invention is liquid preparation (oral liquid or a syrup), compares with Chinese medicine antibiotic medicine commonly used, is more conducive to absorption of human body, and is rapid-action, taking convenience, and the each age group crowds such as old man, child that are suitable for take.
Above-described embodiment describes preferred implementation of the present invention; Be not that scope of the present invention is limited; Design under the prerequisite of spirit not breaking away from the present invention; Various distortion and improvement that those of ordinary skills make technical scheme of the present invention all should fall in the definite protection domain of claims of the present invention.
Claims (10)
1. an anti-inflammatory medicine compositions is characterized in that: contain following parts by weight of Chinese traditional medicine raw material: Herba monochasmatis 1500-1568, Herba Commelinae 745-788, Herba Hedyotidis Diffusae 745-788.
2. Chinese medicine composition according to claim 1 is characterized in that: contain following parts by weight of Chinese traditional medicine raw material: Herba monochasmatis 1550-1566, Herba Commelinae 750-785, Herba Hedyotidis Diffusae 750-785.
3. Chinese medicine composition according to claim 1 is characterized in that: contain following parts by weight of Chinese traditional medicine raw material: Herba monochasmatis 1562.5, Herba Commelinae 781.25, Herba Hedyotidis Diffusae 781.25.
4. the scorching peaceful liquid preparation that claim 1,2 or 3 described Chinese medicine compositions prepare is characterized in that: for not containing the oral drug preparation form of medicinal adjuvant.
5. the scorching peaceful liquid preparation that claim 1,2 or 3 described Chinese medicine compositions prepare is characterized in that: for containing the oral drug preparation form of sucrose or sweeting agent.
6. the peaceful liquid preparation of inflammation according to claim 4 is characterized in that: said preparation is an oral liquid.
7. the peaceful liquid preparation of inflammation according to claim 5 is characterized in that: said preparation is for having sugared type or Sugarless type syrup.
8. the peaceful liquid preparation of inflammation according to claim 7 is characterized in that: the weight portion that said sucrose adds is 600-650, and the weight portion that said sweeting agent adds is 0.5-5.
9. prepare the method for claim 6 or the peaceful liquid preparation of 8 described inflammation, it is characterized in that:
Take by weighing each raw medicinal material respectively by claim 1,2 or 3 said proportionings, with raw medicinal material decocte with water twice, for the first time amount of water be medical material weight 6-15 doubly, for the second time amount of water be medical material weight 5-12 doubly; Decocted 1.5 hours for the first time, decocted 1 hour for the second time, collecting decoction filters; It is 1.0-1.10 that filtrating is concentrated into density, adds ethanol, makes to contain the alcohol amount in the filtrating to reach parts by weight be 50%-60%; Stir, left standstill 10-14 hour, filter; Ethanol in the filtrating is reclaimed, and will removing alcoholic acid filtrating, to be concentrated into density be 1.10-1.20 that it is subsequent use to make extract;
Get the sucrose heating for dissolving, add said extracted thing and antiseptic then, heated and boiled keeps little and boiled 20 minutes, is cooled to below 60 ℃, is settled to scale, continues to be cooled to 45-55 ℃, and packing has promptly got sugared type syrup; Perhaps, get the said extracted thing and be heated to 55-65 ℃, add sweeting agent, flavoring agent and antiseptic heated and boiled then, keep little and boiled 20 minutes, be cooled to below 60 ℃, be settled to scale, continue to be cooled to 45-55 ℃, packing promptly gets the Sugarless type syrup; Perhaps, get the said extracted thing and add an amount of purified water heating dilution, add flavoring agent and antiseptic then, heated and boiled keeps little and boiled 20 minutes, is cooled to below 60 ℃, is settled to scale, continues to be cooled to 45-55 ℃, and packing promptly gets oral liquid formulations.
10. the application of each described Chinese medicine composition of claim 1-3 in the preparation anti-inflammation drugs.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660372A (en) * | 2005-01-31 | 2005-08-31 | 北京正大绿洲医药科技有限公司 | Oral drop pill in use for clearing sway heat and toxic material, relieving inflammation and dysentery, and preparation method |
| CN1686492A (en) * | 2005-04-11 | 2005-10-26 | 贵州宏奇药业有公司 | Antibicrobial anti inflammatory capsule and its preparation method |
| CN1730059A (en) * | 2005-06-10 | 2006-02-08 | 湖南麓山天然植物制药有限公司 | Inflammation diminishing capsule and its preparing process |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660372A (en) * | 2005-01-31 | 2005-08-31 | 北京正大绿洲医药科技有限公司 | Oral drop pill in use for clearing sway heat and toxic material, relieving inflammation and dysentery, and preparation method |
| CN1686492A (en) * | 2005-04-11 | 2005-10-26 | 贵州宏奇药业有公司 | Antibicrobial anti inflammatory capsule and its preparation method |
| CN1730059A (en) * | 2005-06-10 | 2006-02-08 | 湖南麓山天然植物制药有限公司 | Inflammation diminishing capsule and its preparing process |
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