CN102793736A

CN102793736A - Buccal tablet with removing throat heat and promoting diuresis

Info

Publication number: CN102793736A
Application number: CN2012102591882A
Authority: CN
Inventors: 苏建丽
Original assignee: Qingdao Wenchuang Technology Co Ltd
Current assignee: Qingdao Wenchuang Technology Co Ltd
Priority date: 2012-07-25
Filing date: 2012-07-25
Publication date: 2012-11-28

Abstract

The invention relates to a buccal tablet with removing throat heat and promoting diuresis. The buccal tablet is prepared from the following 5 raw materials in parts by weight: 100 to 400 parts of elm root bark, 100 to 400 parts of platycodon grandiflorum, 100 to 400 parts of mulberry leaves, 100 to 400 parts of chrysanthemum, and 100 to 400 parts of sunflower seeds. A preparation process of the buccal tablet comprises the following steps: 1) immersing the five raw materials; 2) heating and extracting with water; 3) concentrating the water extract to prepare an extract; 4) drying and crushing the extract to obtain powder; and 5) mixing the powder and auxiliary materials, pelletizing, drying, granulating, and tabletting. The buccal tablet has remarkable effects of removing throat heat and promoting diuresis, and can be used for eliminating the internal dropsy and postpartum edema and unsmooth lactation of a parturient.

Description

A kind of buccal tablet with the effect of moistening and cleaning throat diuretic

Technical field

The present invention relates to a kind of oral tablet, relate in particular to a kind of buccal tablet, this buccal tablet has the effect of moistening and cleaning throat diuretic.

Background technology

Buccal tablet because of its good mouthfeel and easily instructions of taking receive the welcome of extensive patients.It has the following advantages: 1. act directly on pharyngeal.Have effects such as antibacterial, antibacterial, antiinflammatory, detumescence, desaturation thick secretions, convergence, stimulating mucosal secretion.2. because containing slowly, it is pharyngeal that medicine can be rested on the long period, continues the performance drug effect.3. for alleviating uncomfortable sensation such as dry pharynx, pharyngalgia instant effect.Simultaneously, because the buccal tablet mouthfeel is good, taking convenience receives broad masses' welcome deeply.

But buccal tablet before often is confined to the treatment of pharyngeal discomfort, also can get into blood circulation because oral mucosa absorbs the back medicine, so utilize the buccal tablet mouthfeel good, the advantage of taking convenience also can reach other health care purpose.And this respect research is less in the actual life, such as the preparation of the buccal tablet that does not relate to the moistening and cleaning throat diuretic.

All the time, edema is often perplexing all kinds of crowds, and edema is divided into following several types:

Idiopathic edema: some women of 20 to 40 years old, after getting up morning, the normal had slight edema of eyelid and face, lower limb have pitting edema or tight sense, along with activity, alleviate gradually or disappear.

Reactive edema: particularly work in hot environment or health are more fat does not like movable person again for some people, receive the influence of high ambient temperature, the skin heart diffusion; The body fluid infiltration also accumulates in subcutaneous tissue, and the hands of being everlasting, foot etc. locate to take place edema, after summer; Then disappear voluntarily, but every Xia Bifa, repeatedly for many years.

Position property edema: stand for a long time, walk, squat down or seat, can be because of the lower limb obstruction of blood return, alluvial causes edema, and a period of time behind the change position, edema can alleviate voluntarily, disappears.

Premenstruum edema: some health female is in menstrual onset the last week or two weeks; Eyelid, the back of the hand, ankle even the slight edema of two lower limb appear; And symptom such as agitation, insomnia, tired, headache, during menstrual onset, edema and other symptoms can disappear gradually.

Medicine property edema: as using medicines such as adrenocortical hormone, testosterone, androgen, insulin, thiourea, Radix Glycyrrhizae, can cause face, hands, foot edema to occur, edema can disappear gradually after the drug withdrawal.

Puerperal edema: puerperal especially after the cesarean in order to diminish inflammation, prevention infection is infused in body in a large number, and moisture period of retention is in vivo easily just during this period of time caused puerperal edema easily, and difficult the elimination.

Edema has caused influence to the personage that much likes to be beautiful, and also very unfavorable to the operation of physical function of self.The past people perhaps let matters drift, and perhaps adopt the way of dietetic therapy, but dietetic therapy are not suitable for present allegro life sometimes.The needs that also do not have at present a kind ofly conveniently to take, effective, the buccal tablet with the effect of moistening and cleaning throat diuretic that mouthfeel is good satisfy everybody.

Summary of the invention

The problem that the present invention need solve provides and a kind ofly conveniently takes, the buccal tablet with the effect of moistening and cleaning throat diuretic effective, that mouthfeel is good satisfies everybody needs for detumescencing diuresis.

Technical problem to be solved by this invention realizes through following technical scheme:

A kind of buccal tablet with the effect of moistening and cleaning throat diuretic, this buccal tablet is made by following raw material:

Radix et Cortex ulmi pumilae 100-400 weight portion Radix Platycodonis 100-400 weight portion

Folium Mori 100-400 weight portion Flos Chrysanthemi 100-400 weight portion certain herbaceous plants with big flowers 100-400 weight portion

Wherein, Radix et Cortex ulmi pumilae is the root bark of Ulmaceae plant elm, and sweet in the mouth, property are put down.Loosening bowel to relieve constipation is arranged, inducing diuresis to remove edema, the effect of heat-clearing and toxic substances removing.Be applicable to abdominal distention, constipation, edema and dysuria.

Radix Platycodonis is the dried roots of campanulaceae Platycodon grandiflouorum, bitter in the mouth, suffering, and slightly warm in nature is gone into lung meridian.The ability expelling phlegm for arresting cough, and lung qi dispersing, evacuation of pus effect are arranged.Its young stem and leaf and root all can supply cooked food, abound with in area, China northeast, and be the speciality of Korean nationality.

Folium Mori are dried leaves of moraceae plants Mulberry, have another name called tame Mulberry, Jing Sang, Fructus Mori tree, yellow wood etc., and national most of areas has production more, has effects such as blood pressure lowering, blood fat reducing, antiinflammatory, diuresis, can dispelling wind and heat pathogens, and clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.

Flos Chrysanthemi, perennial catananche, its petal is ligule or tubular.Diffusing wind heat clearing away, suppressing the hyperactive liver makes eye bright.Be used for anemopyretic cold, it is dizzy to have a headache, conjunctival congestion and swelling pain, and eyes is dim-sighted, and calmness, refrigeration function are arranged.Staphylococcus aureus, group B streptococcus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli, bacillus pyocyaneus, mycobacterium hominis and influenza virus all there is inhibitory action.

Certain herbaceous plants with big flowers has another name called Semen Abutili, certain herbaceous plants with big flowers colza.Be the mature seed of Malvaceae annual herb plant Semen Abutili, all produce all over China.Gather during seed maturity summer and autumn, dries, and gives birth to usefulness, smashs to pieces and be used as medicine.These article are sweet cold sliding sharp, can relieving stranguria by diuresis, again can stimulating milk secretion, intestine moistening, and difficulty in urination and defecation person is all suitable.

By the buccal tablet that above medical material is processed, prescription is balanced, wherein, Radix et Cortex ulmi pumilae, Folium Mori, all ability diuresis of certain herbaceous plants with big flowers, intestine moistening, and Radix Platycodonis, Flos Chrysanthemi, Folium Mori can loose wind heat clearing away, throat-benefiting have antiinflammatory, bacteriostatic effect concurrently.Thus can moistening and cleaning throat, again can diuretic.Simultaneously, this side also is applicable to women's puerperal edema, the stimulating milk secretion impassable patient.

This buccal tablet is conveniently taken, mouthfeel is good, effect is good, and the puzzlement that can solve the suffered edema of most of people does not freely have good effect for women's puerperal edema, stimulating milk secretion simultaneously, makes that the women can be popular Gospel in fast quick-recovery figure in puerperal.

The specific embodiment

The present invention is preferred, aforesaid buccal tablet with the effect of moistening and cleaning throat diuretic, and this buccal tablet is made by following raw material:

Radix et Cortex ulmi pumilae 100 weight portion Radix Platycodoniss 100 weight portion Folium Mori 100 weight portions

Flos Chrysanthemi 100 weight portion certain herbaceous plants with big flowers 100 weight portions

A kind of method for preparing with buccal tablet of moistening and cleaning throat diuretic effect can may further comprise the steps:

1) to Radix et Cortex ulmi pumilae 100-400 weight portion, Radix Platycodonis 100-400 weight portion, Folium Mori 100-400 weight portion, Flos Chrysanthemi 100-400 weight portion, in the certain herbaceous plants with big flowers 100-400 weight portion, the water logging that adds 5-20 times of volume of medical material gross weight was steeped 30-60 minute;

2) heating steps 1) in medical material and water, make temperature remain on 80-100 ℃, water is carried 0.5-3 hour, filters; Filtering residue uses the water of 5-20 times of volume of medical material gross weight respectively, and heating makes temperature remain on 80-100 ℃, repeats water and carries 1-3 time, each 0.5-3 hour, filters merging filtrate;

3) will filtrate and concentrate, preparation proportion is the mastic between the 1.2-1.8 g/cm3;

4) with after mastic vacuum decompression crushed after being dried or the spray drying, cross the 60-120 mesh sieve, make the medicated powder powder;

5) get the powder 50-100 weight portion that step 4) makes, carboxymethyl starch sodium 0.1-10 weight portion, sweeting agent 50-300 weight portion, behind the mix homogeneously, adding concentration is the ethanol 5-100 weight portion granulation between the 50-95%, drying, granulate.

6) in the intermediate products behind granulate, behind adding aromatic 0.05-10 weight portion and lubricant 3 weight portions, tabletting promptly gets.

Wherein sweeting agent is selected from one or more in the group of being made up of functional monosaccharide, functional oligose, multi-sugar alcohol, glucosides, dipeptide, protein-based, sucrose derivative, artificial synthesis edulcorant and composite sweetener; Aromatic is selected from natural perfume material and/or artificial perfume, and lubricant is selected from one or more in the group of being made up of magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, polyethylene glycols and the pure magnesium sulfate of moon extension.

In the group that the preferred free high fructose syrup of functional monosaccharide, fructose and L-sugar etc. are formed one or more; In the group that the preferred free isomaltulose of functional oligose, lactulose, Raffinose, soybean oligo saccharide, oligofructose, oligomeric lactulose, oligomeric lactose and oligomeric isomaltose etc. are formed one or more; In the group that the preferred free erythritol of multi-sugar alcohol, xylitol, Sorbitol, mannitol, maltose alcohol, the pure and mild hydrogenated starch hydrolysate of dextrinose etc. are formed one or more; In the group that the preferred free stevioside of glucosides, Flos Chrysanthemi disaccharidase glycosides, dihydrochalcone and glycyrrhizin etc. are formed one or more; Preferred aspartame of dipeptide and/or alitame; Protein-based preferably one or more in the group that Suo Matian, Mo Nailin and kiwi fruit etc. are formed; Sucrose derivative is preferably from sucralose etc.; In the group that the preferred free glucide of artificial synthesis edulcorant, cyclamate and acesulfame-K etc. are formed one or more; In the group that the preferred free Fructus Citri Limoniae of natural perfume material, Fructus Foeniculi, Oleum menthae and Oleum Eucalypti etc. are formed one or more; In the group that the preferred free apple essence of artificial perfume, flavoring orange essence, flavoring banana essence, Mentholum and orange flavor etc. are formed one or more.

A kind of method for preparing with buccal tablet of moistening and cleaning throat diuretic effect, this step specifically can be:

1) to Radix et Cortex ulmi pumilae 100 weight portions, Radix Platycodonis 100 weight portions, Folium Mori 100 weight portions, Flos Chrysanthemi 100 weight portions, the water logging that adds 12 times of volumes of medical material gross weight in certain herbaceous plants with big flowers 100 weight portions was steeped 30 minutes;

2) heating steps 1) in medical material and water, boiled 2 hours, filter, filtering residue adds the water heating of 10 times of volumes of medical material gross weight once more, boils 2 hours, filters merging filtrate;

3) will filtrate and concentrate, preparation proportion is the mastic of 1.5g/cm3;

4) with mastic vacuum decompression crushed after being dried, cross 120 mesh sieves, make the medicated powder powder;

5) get powder 100 weight portions that step 4) makes, carboxymethyl starch sodium 1 weight portion, sucrose 50 weight portions, hydroxyl isomaltulose 100 weight portions behind the mix homogeneously, add 95% ethanol, 15 weight portions and granulate drying, granulate.

6) take by weighing Mentholum 3 weight portions and be dissolved in the intermediate products that spray in the small amount of ethanol behind the granulate, after other added Pulvis Talci 3 weight portions, tabletting promptly got.

The tradition buccal tablet is applicable to usually to be sucked, because tablet hardness is big, disintegrate is slow under one's belt, the drug absorption weak effect when directly swallowing.And used carboxymethyl starch sodium in the preparation process of buccal tablet of the present invention; Carboxymethyl starch sodium is a disintegrating agent commonly used in the common swallow tablet, and the inventor is through exploring, and makes the method for preparing of this buccal tablet; The big characteristics of buccal tablet hardness had both been satisfied; The also interior disintegrate of effective time under one's belt can directly be swallowed so this buccal tablet both can have been sucked also simultaneously, did not influence the drug absorption effect; Used hydroxyl isomaltulose; It has the pure taste as sucrose; Do not have bad aftertaste and abnormal flavour, can and cover the latter's bad aftertaste and abnormal flavour, agent of low hygroscopicity, high stability with intense sweetener generation synergistic function; Low-yield, non-dental caries property etc. is so it is a kind of perfect sugar substitute.Its suitable diabetic is edible simultaneously, can not cause that blood glucose and insulin rise.And hydroxyl isomaltulose is a kind of good bacillus bifidus MF; Though hydroxyl isomaltulose can not be utilized by the enzyme of human body and most microorganisms system; But can be by the utilization that bacillus bifidus decomposes in the human body intestinal canal; Promote the growth and breeding of bacillus bifidus, keep the microecological balance of intestinal, help the health of human body.

Use the buccal tablet of above-mentioned steps preparation, can preparation promote the puerpera to subside a swelling puerperal and the medicine of stimulating milk secretion in use.

The puerpera especially after the cesarean through the puerpera Yi Fasheng edema of the body of transfusion, be difficult for eliminating.And in recent years, the patient of women's puerperal hypogalactia is increasing, and common dietetic therapy is drunk into a large amount of decoction and also can be increased the weight of edema, is difficult to satisfy the personage's that likes to be beautiful needs.Buccal tablet of the present invention contains diuretic and following composition of milk, and as oral medicine, need not cook or decoct, and can easily solve the difficult problem that need subside a swelling simultaneously with stimulating milk secretion.

Further describe the present invention below in conjunction with specific embodiment, advantage of the present invention and characteristics will be more clear along with description.But these embodiment only are exemplary, scope of the present invention are not constituted any restriction.It will be understood by those skilled in the art that and down can make amendment with form or replace without departing from the spirit and scope of the present invention, but these modifications and replacing all fall in protection scope of the present invention the details of technical scheme of the present invention.

1 one kinds of buccal tablets with moistening and cleaning throat diuresis of embodiment are made by following five kinds of medical materials:

Embodiment 2 is according to the concrete method for preparing of embodiment 1 described buccal tablet:

3) will filtrate and concentrate, preparation proportion is the mastic of 1.5 g/cm3;

5) get powder 100 weight portions that step 4) makes, carboxymethyl starch sodium 1 weight portion, sucrose 50 weight portions, hydroxyl isomaltulose 100 weight portions, mix homogeneously is crossed 100 mesh sieves.

6) ethanol 15 weight portions of adding 95% in the intermediate products that step 5) obtains, the preparation soft material uses granulator to granulate, and crosses 16 mesh sieves.Intermediate products after granulating are put into baking oven under 45 ℃, carried out drying 2 hours, use pelletizing machine to carry out granulate then, cross 18 mesh sieves.

7) take by weighing Mentholum 3 weight portions and use the small amount of ethanol dissolving to spray in the intermediate products that step 6) obtains, add Pulvis Talci 3 weight portions, mix homogeneously, tabletting promptly gets, and sheet focuses between the 0.8-0.85g.

The investigation of the moistening and cleaning throat effect of the buccal tablet of preparation among embodiment 3 embodiment 2

1 method

1.1 study subject: select the age between 18 to 65 years old, the chronic pharyngitis patient of main organs illness such as no severe cardiac, liver, kidney is a study subject.

1.2 instructions of taking: 3 times on the 1st, 1 time 2 (buccal) taken 7 days

2 observation index

The inquiry medical history, observe cardinal symptom: pharyngalgia, itching throat, dry pharynx, dry cough and foreign body sensation, investigate the variation of pharyngeal sensation before and after taking and the improvement situation of cardinal symptom.

3 effect criterion

New Chinese medicine clinical research guideline with reference to the Ministry of Public Health promulgation is formulated

3.1 produce effects: symptom obviously alleviates or disappears

3.2 effectively: sx

3.3 it is invalid: the symptom no change

4 results

4.1 physical data: observe 50 routine experimenters altogether, male's 20 examples wherein, women's 30 examples, minimum 18 years old of age, maximum 65 years old, average 40 ± 5 years old.The course of disease is the shortest 1 year, and is the longest 26 years, average 11 ± 6 years.

4.2 the effect of cleaning throat and moistening larynx

The effect of table 1 cleaning throat and moistening larynx

4.3 doing well,improving situation

Table 2 doing well,improving situation

Symptom	The example number	Produce effects	Effectively	Invalid	Total effective rate (%)
						Pharyngalgia	31	7	18	6	80.6
Itching throat	42	12	23	7	83.3
						Dry pharynx	46	4	27	15	67.4
Dry cough	38	4	21	13	65.8
						Foreign body sensation	43	5	22	16	62.8

5 conclusions

The buccal tablet of preparation has the effect of moistening and cleaning throat among the embodiment 2.

The buccal tablet of preparation is for the investigation of the diuretic effect of rat and mice among embodiment 4 embodiment 2

1 experiment material

1.1 experiment medicine

The buccal tablet of preparation among the embodiment 2,36/box of SANJIN PIAN (Sanjin Pharmaceutical Co., Ltd., Guilin provides).

1.2 animal and instrument

Cleaning Kunming mouse 18-22g, SD rat 150-200g provides by Shenyang Chinese Medical Sciences University Experimental Animal Center.

2 experimental techniques

2.1 bell jar process

Select 50 of the rats of body weight 150-200g for use, each is half the for male and female, is divided into 5 groups, 10 every group, is respectively buccal tablet high dose group, middle dose groups, the low dose group of preparation among blank group, positive controls, the embodiment 2.Face with before being mixed with suspension, successive administration 7 days is in advance bell jar endoadaptation 2 days; Water 14h is can't help in fasting before the experiment; When beginning experiment gently depressed abdomen, drains surplus urine, and immediately rat put in people's bell jar behind the last gastric infusion; 1 of every bell jar collects 1,2,3 respectively, 4h urine and do urinalysis.

2.2 mice filter paper weight method

Select 50 of the mices of body weight 18-22g for use, each is half the for male and female, is divided into 5 groups, is respectively buccal tablet high dose group, middle dose groups, the low dose group of preparation among blank group, positive controls, the embodiment 2.Face with before being mixed with suspension; Every group 10, successive administration 7 days, fasting can't help water 14 hours before the experiment; Gently depress abdomen during the experiment beginning; Drain surplus urine, and immediately per 2 of mice is placed respectively in 1 glass bell jar behind the last gastric infusion, the gain in weight of the filter paper of weighing immediately after at every turn urinating with analytical balance weight method record.Observed 4 hours continuously, remove the mice faecal pellet on the filter paper when weighing.

3 experimental results

3.1 the buccal tablet of preparation is to the diuresis of rat among the embodiment 2

Buccal tablet high dose group, middle dose groups, the low dose group of preparation all can obviously increase the rat urine amount among the embodiment 2, with the blank group relatively, difference has significance meaning (P < 0.05).Compare nonsignificance (P>0.05) with positive controls.The urinalysis result shows that we do not change the urine composition, see table 3, table 4.

The buccal tablet of preparation is to the experimental result of rat diuresis among table 3 embodiment 2

Annotate: compare * P < 0.05 with the blank group

The buccal tablet of preparation is to the experimental result of rat diuresis among table 4 embodiment 2

Group	Dosage (g/kg)	Tatol emiction quantity
			Blank control group	-	4.29±1.37
Positive group	0.282	7.89±1.73
			High dose group	1.4	7.31±0.66
Middle dose groups	0.7	7.51±1.64
			Low dose group	0.35	6.99±1.44

Annotate: comparing with SANJIN PIAN does not have significant difference

3.2 the buccal tablet of preparation is to the diuresis of mice among the embodiment 2

The buccal tablet high dose group of preparation among the embodiment 2, middle dose groups, low dose group can obviously increase the mice voided volume, and the urine amount is compared difference significance (P < 0.05) with the blank group, relatively do not have significant difference with positive controls, sees table 5, table 6.

The buccal tablet of preparation is to the experimental result of mice diuresis among table 5 embodiment 2

Group	Dosage (g/kg)	Tatol emiction quantity (g)
			Blank control group	-	0.14±0.13
Positive group	0.47	0.24±0.12*
			High dose group	2.8	0.22±0.15*
Middle dose groups	1.4	0.21±0.12*
			Low dose group	0.7	0.19±0.11*

Annotate: compare * P < 0.05 with the blank group

The buccal tablet of preparation is to the experimental result of mice diuresis among table 6 embodiment 2

Group	Dosage (g/kg)	Tatol emiction quantity
			Blank control group	-	0.14±0.13
Positive group	0.47	0.24±0.12
			High dose group	2.8	0.22±0.15
Middle dose groups	1.4	0.21±0.12
			Low dose group	0.7	0.19±0.11

Annotate: comparing with SANJIN PIAN does not have notable difference

4 conclusions

The buccal tablet of preparation shows rat and mice diuresis result of the test among the embodiment 2; Tangible diuresis was all arranged after administration in 1,2,3,4 hour; Its diuresis was reaching the peak in 2-3 hour. in the medication 4 hours among SANJIN PIAN and the embodiment 2 buccal tablet of preparation the voided volume of rat and mice all obviously is superior to normal saline. but the buccal tablet for preparing among SANJIN PIAN and the embodiment 2 urinated and do not have significant difference between the total amount in 4 hours, thereby the buccal tablet for preparing in the illustrative embodiment 2 has the diuresis of similar SANJIN PIAN.

The buccal tablet of preparation is applied to promote puerpera Ruzhong under puerperal among embodiment 5 embodiment 2

1 method

1.1 study subject: all cases are primiparity, single tire, and vagina production or dig the palace and produce agalactia or the very few patient of breast in 3 days puerperal is got rid of with serious pregnancy complication and complication and the patient that taken the medicine that influences galactopoiesis.

1.2 diagnostic criteria:

Agalactia: the conscious breast of puerpera in 2-3 days puerperal does not expand, and no milk is discharged, and the inspection breast is soft, does not still have milk during extruding and discharges.

Hypogalactia: the conscious breast of puerpera in 2-3 days puerperal does not expand not bitterly, and milk is rare, and neonate needs frequently to suck for a long time, continues to surpass 20min, and at interval less than 1 hour, breast is full not obvious during inspection, and a small amount of milk is arranged during extruding.

Eliminating is obstructed because of the human milk silt that crater nipple and cracked nipple cause, dysilthia.

The buccal tablet 3 times on the 1st of preparation among 1.3 instructions of taking: the embodiment 2,1 time 4, Fructus Chaenomelis gold carp soup is drunk in daily cooperation.

2 curative effect determinate standards: intend certainly

2.1 produce effects: the milk amount can satisfy the baby has enough, and does not need with milk.

2.2 effectively: the milk amount can satisfy consumption by infants basically, the interpolation milk of partly still needing, but be no more than 30ml at every turn.

2.3 invalid: the milk amount can not satisfy consumption by infants, relies on artificial feeding basically, and is with milk at every turn＞30ml.

3 results

3.1 physical data: puerperal hypogalactia women 60 examples, wherein age average (29 ± 3) year; Pregnant Zhou Pingjun (38.2 ± 1.4) week; Average (162.1 ± 5.1) cm of height; Weight average (71.2 ± 9.8) kg.

3.2 doing well,improving situation

Table 6 doing well,improving situation

Symptom	The example number	Produce effects	Effectively	Invalid	Total effective rate (%)
						Agalactia	12	2	6	4	66.7
Hypogalactia	48	7	34	7	85.4

3.3 conclusion

The buccal tablet of preparation has the effect that promotes puerpera's stimulating milk secretion in puerperal among the embodiment 2, is applicable to the puerperal hypogalactia patient.

Claims

1. buccal tablet with the effect of moistening and cleaning throat diuretic is characterized in that this buccal tablet is made by following raw material:

Folium Mori 100-400 weight portion Flos Chrysanthemi 100-400 weight portion certain herbaceous plants with big flowers 100-400 weight portion.

2. buccal tablet according to claim 1 is characterized in that this buccal tablet is made by following raw material:

Flos Chrysanthemi 100 weight portion certain herbaceous plants with big flowers 100 weight portions.

3. the method for preparing of the described buccal tablet of claim 1 comprises following steps:

1) to Radix et Cortex ulmi pumilae 100-400 weight portion, Radix Platycodonis 100-400 weight portion, Folium Mori 100-400 weight portion, Flos Chrysanthemi 100-400 weight portion, the water logging that adds 5-20 times of volume of medical material gross weight in the certain herbaceous plants with big flowers 100-400 weight portion was steeped 30-60 minute;

5) get the powder 50-100 weight portion that step 4) makes, carboxymethyl starch sodium 0.1-10 weight portion, sweeting agent 50-300 weight portion, behind the mix homogeneously, adding concentration is the ethanol 5-100 weight portion granulation between the 50-95%, drying, granulate;

6) in the intermediate products behind granulate, behind adding aromatic 0.05-10 weight portion and the lubricant 0.5-10 weight portion, tabletting promptly gets.

4. the method for preparing of buccal tablet according to claim 3, wherein sweeting agent is selected from one or more in the group of being made up of functional monosaccharide, functional oligose, multi-sugar alcohol, glucosides, dipeptide, protein-based, sucrose derivative, artificial synthesis edulcorant and composite sweetener; Aromatic is selected from natural perfume material and/or artificial perfume, and lubricant is selected from one or more in the group of being made up of magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, polyethylene glycols and the pure magnesium sulfate of moon extension.

5. the method for preparing of buccal tablet according to claim 4, wherein, functional monosaccharide is selected from one or more in the group of being made up of high fructose syrup, fructose and L-sugar; Functional oligose is selected from one or more in the group of being made up of isomaltulose, lactulose, Raffinose, soybean oligo saccharide, oligofructose, oligomeric lactulose, oligomeric lactose and oligomeric isomaltose; Multi-sugar alcohol is selected from one or more in the group of being made up of erythritol, xylitol, Sorbitol, mannitol, maltose alcohol, the pure and mild hydrogenated starch hydrolysate of dextrinose; Glucosides is selected from one or more in the group of being made up of stevioside, Flos Chrysanthemi disaccharidase glycosides, dihydrochalcone and glycyrrhizin; Dipeptide is selected from by aspartame and/or alitame; Protein-basedly be selected from the group that Suo Matian, Mo Nailin and kiwi fruit form one or more; Sucrose derivative is selected from sucralose; The artificial synthesis edulcorant is selected from one or more in the group of being made up of glucide, cyclamate and acesulfame-K; Natural perfume material is selected from one or more in the group of being made up of Fructus Citri Limoniae, Fructus Foeniculi, Oleum menthae and Oleum Eucalypti; Artificial perfume is selected from one or more in the group of being made up of apple essence, flavoring orange essence, flavoring banana essence, Mentholum and orange flavor.

6. according to the method for preparing of each described buccal tablet among the claim 3-5, wherein:

5) get powder 100 weight portions that step 4) makes, carboxymethyl starch sodium 1 weight portion, sucrose 50 weight portions, hydroxyl isomaltulose 100 weight portions behind the mix homogeneously, add 95% ethanol, 15 weight portions and granulate drying, granulate;

7. according to the buccal tablet described in claim 1 or 2, preparation promote the puerpera to subside a swelling puerperal and the medicine of stimulating milk secretion in application.