CN104984166A - Care medicine for treating eczema scroti and preparing method thereof - Google Patents
Care medicine for treating eczema scroti and preparing method thereof Download PDFInfo
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- CN104984166A CN104984166A CN201510427179.3A CN201510427179A CN104984166A CN 104984166 A CN104984166 A CN 104984166A CN 201510427179 A CN201510427179 A CN 201510427179A CN 104984166 A CN104984166 A CN 104984166A
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to care medicine for treating eczema scroti and a preparing method thereof. The care medicine is composed of semen coicis, poria cocos, felwort, golden cypress, purslane, radix scrophulariae, fructus kochiae, radix sophorae flavescentis, periostracum cicada, fructus cnidii and the like. The care medicine has the remarkable curative effects of tonifying spleen, clearing damp, clearing away heat and toxic materials, dispelling wind and arresting itching, and it is verified through clinical application that the care medicine has the definite curative effects and a mild medicine property, avoids toxic, side or untoward effects, and can be used as effective medicine for treating eczema scroti particularly damp and hot immersed type eczema scroti.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of nursing medicine for the treatment of eczema scrotum and preparation method thereof.
Background technology
Eczema scrotum is a kind of dermal inflammatory reaction comprising the multiformity erythra such as pruritus, erythema, desquamation and lichenization betiding scrotum portion.The cause of disease is complicated and easily recur, and endogenous cause of ill such as infection focus or spirit change, and exopathogenic factor such as pruritus, friction, food etc. all can cause morbidity.Society due to the change of climatic environment, dietary structure, the quickening of rhythm of life, the increase of stress, the application etc. of a large amount of chemicals, the sickness rate of eczema scrotum is in rising trend, simultaneously because eczema scrotum sufferer position is special, also brings very big puzzlement to the life of patient, work.The traditional Chinese medical science thinks that primary disease belongs to " scrotal eczema ", and " eczema of scrotum " category, as said in " Waike Zhengzong, Orthodox Manual of External Diseases scrotal eczema ": " scrotal eczema is that Liver Channel rheumatism become.Its trouble is had an itch, and broken stream grows water." its cause of disease is not always resistance to by natural disposition, the heresy visitor of rheumatic fever forms in skin.Controlling should with clearing away heat-damp and promoting diuresis, and dispelling wind for relieving itching is principle.
Clinical treatment eczema scrotum method is varied, current doctor trained in Western medicine often gives antihistaminic, vitamin C, sedative hypnotic medicine, coordinate external used medicine as the Drug therapy such as cortical steroid, immunosuppressant, curative effect still can, but there is relevant side effect or potential risk more.Utilize modern scientific research method, science and the reliability of Chinese medicine eczema scrotum are significantly improved, and effective percentage is high, obviously can alleviate the misery of patient, and toxic and side effects is little, the nursing Chinese medicine preparation of therefore profound under instruction of Chinese Medicine theory exploration treatment eczema scrotum to be applied to clinical expansion necessary.
Summary of the invention
The invention provides a kind of nursing medicine for the treatment of eczema scrotum, its safety is high, effective, can be used as the ideal medicament of nursing eczema scrotum.Medicament composing prescription of the present invention is rigorous, compatibility science, easy to prepare, and patient compliance is good, without any side effects, clinic promotion and application.
For achieving the above object, technical scheme provided by the invention is the nursing medicine of described treatment eczema scrotum, and the composition and ratio of its crude drug is: Semen Coicis 12-16g, Poria 8-10g, Radix Gentianae 3-5g, Cortex Phellodendri 6-8g, Herba Portulacae 6-8g, Radix Scrophulariae 1-3g, Fructus Kochiae 8-10g, Radix Sophorae Flavescentis 2-4g, Periostracum Cicadae 8-10g, Fructus Cnidii 6-8g.
Optimal technical scheme of the present invention is, nursing medicine of the present invention is obtained by the material medicine of following weight proportion: Semen Coicis 14g, Poria 9g, Radix Gentianae 4g, Cortex Phellodendri 7g, Herba Portulacae 7g, Radix Scrophulariae 2g, Fructus Kochiae 9g, Radix Sophorae Flavescentis 3g, Periostracum Cicadae 9g, Fructus Cnidii 7g.
Present invention also offers the preparation method of described nursing medicine, specifically comprise: take above Chinese medicine component according to aforesaid weight and pulverized 120 mesh sieves respectively, decoct 2-3 time after soaking 2-3h, add medicine gross weight 6-8 water doubly at every turn, decoct 2-4 hour, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 120-150 mesh sieve, adds pharmaceutically acceptable excipients make clinical acceptable dosage form through normal process steps.
Nursing medicine of the present invention can be prepared into oral formulations, as tablet, capsule or granule, is preferably granule.
The present invention also asks the purposes protecting above-mentioned nursing medicine in the medicine of preparation treatment eczema scrotum.The particularly purposes of described nursing pharmaceutical preparation in the medicine of the damp and hot contamination type eczema scrotum of preparation treatment.
Present invention also offers the clinical observation of described nursing Drug therapy eczema scrotum
1, diagnostic criteria: Western medicine diagnose all cases all meets eczema scrotum diagnostic criteria in " clinic skin venerology ".Tcm diagnosis standard meets damp and hot contamination type eczema scrotum diagnostic criteria in " the TCM Dermatology commonly encountered diseases practice guidelines " of China Association of Traditional Chinese Medicine's issue in 2012: skin lesion color is red scorching hot, papulovesicle is intensive, ooze out obviously, pruritus is heavier, and morbidity is anxious, accompanies vexed, thirsty, indistinctive fever, yellow urine, large dry stool; Red tongue, yellow and greasy fur, rolling pulse or number.
2, physical data: clinical diagnosis is patient's totally 90 examples of eczema scrotum.Be divided into treatment group and matched group at random.Treatment group 45 example, age l9 ~ 68 year old; The course of disease 6 months ~ 10 years; 19 examples are first visit, and 26 examples are further consultation; Acute or subacute 18 examples, chronic 27 examples.Matched group 45 example, 20 ~ 65 years old age; The course of disease 8 months ~ 11 years; 20 examples are first visit, 25 routine further consultations; Acute or subacute 19 examples, chronic 26 examples.Selected by two groups, case did not use cortical steroid and antihistamine drug in two weeks, and further consultation case 2 Zhou Qianjun has various external-applied ointment to treat history.The physical data such as two groups of case ages, courses of disease, through statistical procedures there was no significant difference, have comparability.
3, exclusion standard: (1) does not meet eczema scrotum diagnostic criteria patient; (2) age is less than 18 years old, or is greater than 70 years old; (3) to the medicaments insensitive person observed; (4) took corticosteroid hormone orally in nearly two weeks, used external 17-hydroxy-11-dehydrocorticosterone preparation person in nearly one week and used antihistaminic class medicine person; (5) merge intentionally, cerebrovascular, liver, severe primary disease, the psychotic such as kidney and hemopoietic system; (6) do not meet inclusive criteria, not by regulation medication, cannot curative effect person be judged.
4, Therapeutic Method:
Matched group: take compound tablet of glycyrrhizin (specification: 25mg × 21 slice), half an hour is oral after meal, three times on the one, each two panels.
Treatment group: take granule prepared by embodiment 3, containing crude drug amount 0.5g, every day 2 times, each 1 bag, takes for every bag after meal half an hour.
The course for the treatment of: treating two weeks is a course for the treatment of, treatment adds up clinical efficacy after two courses for the treatment of continuously.Patient's diet tobacco and wine, urine smell, pungent, stimulating food during nursing for treating, as fish and shrimp, Carnis Canitis, Carnis caprae seu ovis, Sanguis sus domestica, Folium Allii tuberosi, Herba Alii fistulosi, Bulbus Allii, Fructus Capsici etc.; Trousers should be loose, and underwear duty is changed clothes, and keeps dry and comfortable; Scrotum should not wash with water, more should not wash with soap, and also should not put on the skin with outside tiger balm, Herba Menthae wet goods, pruritus should not be scratched.
5, the standard of curative effect evaluation:
1. cure: scrotum skin lesion all disappears and takes off, without plumpness, sepage, incrustation;
2. effective: skin lesion disappears 70%, without pruritus, sepage;
3. effective: skin lesion disappears and takes off 30%, there is slight pruritus;
4. invalid: skin lesion and subjective symptoms are without alleviating.
Total effective rate=cure rate+obvious effective rate.
6, therapeutic effect:
90 routine patients, without coming off, exiting case, all complete clinical observation.
Two courses for the treatment of terminate the rear therapeutic effect to two groups of patients and carry out observation and comparison, the routine patient of matched group 45, and 6 examples are cured, and 20 examples are effective, and 13 examples effectively, 6 examples are invalid, total effective rate 57.8%, the routine patient for the treatment of group 45, and 15 examples are cured, 25 examples are effective, and effectively, 2 examples are invalid, total effective rate 88.9% for 3 examples.Treatment group is obviously better than matched group.Concrete clinical efficacy the results are shown in following table 1.
Table 1. liang group Clinical efficacy comparison
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate |
| Matched group | 45 | 6 | 20 | 13 | 6 | 57.8％ |
| Treatment group | 45 | 15 | 25 | 3 | 2 | 88.9％ |
The above results shows, after eczema scrotum patient the application of the invention nursing Drug therapy, symptom can significantly improve, and in addition, treatment group before the treatment rear body weight, heart rate, blood pressure is showed no obvious change.Treatment group does not find obvious adverse events in whole therapeutic process.Illustrate that nursing medicine of the present invention is at nursing eczema scrotum particularly determined curative effect in the damp and hot contamination type eczema scrotum of nursing thus, safety is high, can be used as the nursing medicine for the treatment of eczema scrotum, is worth studying and applying further.
The present invention, relative to prior art, has following clear superiority:
Nursing medicament composing prescription of the present invention mainly develops according to the pathogenic characteristic of eczema scrotum patient, Semen Coicis in side, Poria spleen invigorating eliminating dampness by diuresis, promoting diuresis to calm the heart; Radix Gentianae, Cortex Phellodendri heat clearing and damp drying, detoxification sore treatment; Herba Portulacae, Radix Scrophulariae clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body; The Fructus Kochiae, Radix Sophorae Flavescentis, Fructus Cnidii heat clearing and damp drying, dispelling wind for relieving itching; Periostracum Cicadae falls apart wind heat extraction, rash spasmolytic.In prescription, all medicines share and have spleen invigorating dehumidifying, and heat-clearing and toxic substances removing, the significant curative effect of dispelling wind for relieving itching, has extremely strong pertinent nursing effect to eczema scrotum especially damp and hot contamination type eczema scrotum.Through clinical practice checking, its determined curative effect, mild in medicine property and, do not occur toxic and side effects and untoward reaction, safety coefficient is high.
Further, in nursing medicine of the present invention, the function of each crude drug cures mainly:
Semen Coicis is sweet, light, cool.Return spleen, stomach, lung meridian.Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
Poria is sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Radix Gentianae, bitter, cold.Return liver, gallbladder meridian.Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms.
Cortex Phellodendri, bitter, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Herba Portulacae, acid, cold.Return liver, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.
Radix Scrophulariae, sweet, bitter, salty, be slightly cold.Return lung, stomach, kidney channel.Removing heat from blood YIN nourishing, eliminating fire and detoxication.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
The Fructus Kochiae is pungent, bitter, cold.Return kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Radix Sophorae Flavescentis is bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel.Heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Fructus Cnidii, acrid, bitter, warm.Enter kidney, spleen channel.Warming the kidney to activate YANG, dispels the wind, dampness, parasite killing.Control impotence in male, scrotum pruritus due to damp pathogen, woman's leukorrhagia pudendal pruritus, cold uterus is infertile, rheumatic arthralgia, scabies eczema.
Periostracum Cicadae, sweet, cold.Return lung, Liver Channel.Loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 tablet
The each raw material of the present invention is taken: Semen Coicis 14g, Poria 9g, Radix Gentianae 4g, Cortex Phellodendri 7g, Herba Portulacae 7g, Radix Scrophulariae 2g, Fructus Kochiae 9g, Radix Sophorae Flavescentis 3g, Periostracum Cicadae 9g, Fructus Cnidii 7g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and pulverized 120 mesh sieves respectively, decoct 2 times after soaking 2h, add the water of medicine gross weight 6 times at every turn, decoct 2 hours, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 120 mesh sieves, adds pharmaceutically acceptable excipients make tablet through normal process steps.
When using the present invention to nurse by Drug therapy eczema scrotum, take prepared tablet, every sheet is containing crude drug amount 0.15g, and every day 2 times, each 2-4 sheet, takes after meal half an hour.
Embodiment 2 capsule
The each raw material of the present invention is taken: Semen Coicis 14g, Poria 9g, Radix Gentianae 4g, Cortex Phellodendri 7g, Herba Portulacae 7g, Radix Scrophulariae 2g, Fructus Kochiae 9g, Radix Sophorae Flavescentis 3g, Periostracum Cicadae 9g, Fructus Cnidii 7g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and pulverized 120 mesh sieves respectively, decoct 3 times after soaking 3h, add the water of medicine gross weight 6 times at every turn, decoct 3 hours, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 120 mesh sieves, adds pharmaceutically acceptable excipients make capsule through normal process steps.
When using the present invention to nurse by Drug therapy eczema scrotum, take prepared capsule, every contains crude drug amount 0.15g, and every day 2 times, each 2-4 grain, takes after meal half an hour.
Embodiment 3 granule
The each raw material of the present invention is taken: Semen Coicis 14g, Poria 9g, Radix Gentianae 4g, Cortex Phellodendri 7g, Herba Portulacae 7g, Radix Scrophulariae 2g, Fructus Kochiae 9g, Radix Sophorae Flavescentis 3g, Periostracum Cicadae 9g, Fructus Cnidii 7g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and pulverized 120 mesh sieves respectively, decoct 3 times after soaking 3h, add the water of medicine gross weight 7 times at every turn, decoct 3 hours, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 120 mesh sieves, adds pharmaceutically acceptable excipients make granule through normal process steps.
When using Chinese medicine preparation of the present invention to treat eczema scrotum, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
Embodiment 4 granule
The each raw material of the present invention is taken: Semen Coicis 12g, Poria 8g, Radix Gentianae 3g, Cortex Phellodendri 6g, Herba Portulacae 6g, Radix Scrophulariae 1g, Fructus Kochiae 8g, Radix Sophorae Flavescentis 2g, Periostracum Cicadae 8g, Fructus Cnidii 6g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and pulverized 120 mesh sieves respectively, decoct 2 times after soaking 3h, add the water of medicine gross weight 6 times at every turn, decoct 3 hours, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 150 mesh sieves, adds pharmaceutically acceptable excipients make granule through normal process steps.
When using Chinese medicine preparation of the present invention to treat eczema scrotum, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
Embodiment 5 granule
The each raw material of the present invention is taken: Semen Coicis 16g, Poria 10g, Radix Gentianae 5g, Cortex Phellodendri 8g, Herba Portulacae 8g, Radix Scrophulariae 3g, Fructus Kochiae 10g, Radix Sophorae Flavescentis 4g, Periostracum Cicadae 10g, Fructus Cnidii 8g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and pulverized 120 mesh sieves respectively, decoct 3 times after soaking 2h, add the water of medicine gross weight 8 times at every turn, decoct 4 hours, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 120 mesh sieves, adds pharmaceutically acceptable excipients make granule through normal process steps.
When using Chinese medicine preparation of the present invention to treat eczema scrotum, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
Claims (7)
1. treat a nursing medicine for eczema scrotum, it is characterized in that, the composition and ratio of its crude drug is: Semen Coicis 12-16g, Poria 8-10g, Radix Gentianae 3-5g, Cortex Phellodendri 6-8g, Herba Portulacae 6-8g, Radix Scrophulariae 1-3g, Fructus Kochiae 8-10g, Radix Sophorae Flavescentis 2-4g, Periostracum Cicadae 8-10g, Fructus Cnidii 6-8g.
2. a kind of nursing medicine for the treatment of eczema scrotum as claimed in claim 1, it is characterized in that, the composition and ratio of its primary raw material medicine is: Semen Coicis 14g, Poria 9g, Radix Gentianae 4g, Cortex Phellodendri 7g, Herba Portulacae 7g, Radix Scrophulariae 2g, Fructus Kochiae 9g, Radix Sophorae Flavescentis 3g, Periostracum Cicadae 9g, Fructus Cnidii 7g.
3. a kind of nursing medicine for the treatment of eczema scrotum as described in claim 1,2, it is characterized in that, the preparation method of described pharmaceutical composition comprises following steps: take above Chinese medicine component according to aforesaid weight and pulverized 120 mesh sieves respectively, decoct 2-3 time after soaking 2-3h, add medicine gross weight 6-8 water doubly at every turn, decoct 2-4 hour, merge decoction liquor, filter; When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, and cold drying, pulverized 120-150 mesh sieve, adds pharmaceutically acceptable excipients make clinical acceptable dosage form through normal process steps.
4. a kind of nursing medicine for the treatment of eczema scrotum as claimed in claim 3, it is characterized in that, described nursing medicine can be made into oral formulations.
5. a kind of nursing medicine for the treatment of eczema scrotum as claimed in claim 4, it is characterized in that, described oral formulations is preferably tablet, capsule or granule.
6. the purposes of nursing medicine as claimed in claim 1 or 2 in the medicine of preparation treatment eczema scrotum.
7. the purposes of nursing medicine as claimed in claim 1 or 2 in the medicine of the damp and hot contamination type eczema scrotum of preparation treatment.
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| CN105770655A (en) * | 2016-04-24 | 2016-07-20 | 邹洪胜 | Traditional Chinese medicine composition for treating scroti eczema |
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