CN101837095B - American cockroach medicinal composition for curing gastritis and peptic ulcers and preparation method thereof - Google Patents

American cockroach medicinal composition for curing gastritis and peptic ulcers and preparation method thereof Download PDF

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CN101837095B
CN101837095B CN201010182359A CN201010182359A CN101837095B CN 101837095 B CN101837095 B CN 101837095B CN 201010182359 A CN201010182359 A CN 201010182359A CN 201010182359 A CN201010182359 A CN 201010182359A CN 101837095 B CN101837095 B CN 101837095B
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耿福能
刘彬
黄婉怡
胡若瑛
杜江
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Abstract

The invention discloses an American cockroach medicinal composition for curing gastritis and peptic ulcers. The medicinal composition is mainly prepared from an active ingredient mixture prepared by mixing an American cockroach extract, white peony root, bletilla, radix pseudo-ginseng, liquoric root, Indian buead, rhizoma corydalis, cuttlebone and belladonna extract. The weight part ratio of the American cockroach extract to the white peony root to the bletilla to the radix pseudo-ginseng to the liquoric root to the Indian buead to the rhizoma corydalis to the cuttlebone to the belladonna extract is equal to 0.8-1. 2g :1-10g:1-10g:0.5-6g:0.25-6g:0.25-10g:0.5-6g:0.83-6g:5-60mg. A preparation method of the American cockroach medicinal composition for curing the gastritis and the peptic ulcers comprises the following steps of: preparing the American cockroach extract, weighting, decocting, and mixing active ingredients, and preparing medicaments. The medicinal composition has simple preparation method, fully exerts effects of the American cockroach extract, and effectively improves curative effects on the gastritis and the peptic ulcers.

Description

A kind of American cockroach medicament composition of treating gastritis and peptic ulcer and preparation method thereof
Technical field
The present invention relates to medical technical field, specifically relate to a kind of American cockroach medicament composition of treating gastritis and peptic ulcer and preparation method thereof.
Background technology
It is documented that periplaneta americana is the maximum insecticide of volume in the Blattidae, originates in South America; Periplaneta americana is the traditional Chinese medicines material, is used as medicine its property plug salty in the mouth with dry and bright adult; Poisonous, acid is arranged, functions such as dissipating blood stasis, removing food stagnancy, detoxifcation, diuretic, detumescence are arranged; Curing mainly infantile malnutrition, tonsillitis, health enclosed mass, carbuncle skin ulcer swells and ache and Scolopendra, venom etc.
In recent years along with science and technology constantly develops, through discovering that for many years the periplaneta americana epidermis contains sclerotin and chitin, elements such as bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium; Muscle hydrolysis 13 seed amino acids; Its alcohol extract has the obvious suppression effect to cancerous cell, and cardiovascular disease is had tangible curative effect.In addition, health storage vitamin B 1, B 2, nicotinic acid and ascorbic acid etc., lymph contain trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc.All contain ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.Clinical main application has: treat infantile malnutrition, control the carbuncle pyogenic infections from tumour or sore, control the Scolopendra wound, control innominate toxic swelling, control the worm venom.But also have periplaneta americana and medical herbs compatibility auxiliary treatment colon cancer.American-cockroach-extract can be controlled hepatitis B, and extract A T-2 preparation can cure mainly primary hepatocarcinoma, cardiovascular disease etc.
Notification number is CN 100525781C; Name is called " American-cockroach-extract, contain pharmaceutical composition of this extract and preparation method thereof " and publication number is CN1943600A; It is two with the American-cockroach-extract relevant patent documentations of applicant in application in 2006 that name is called " pharmaceutical composition and the new purposes thereof that contain periplaneta americana and ethanol extraction thereof "; It discloses the method for preparing and the part medical usage of American-cockroach-extract; In recent years, along with the further research to American-cockroach-extract, American-cockroach-extract has obtained further development in purposes pharmaceutically.
The Radix Paeoniae Alba, nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
The Pseudobulbus Bletillae (Rhizoma Bletillae) has astringing to arrest bleeding, the merit of detumescence and promoting granulation, all cards of external haemorrhage and carbuncle, scald, rhagadia manus et pedis, anal fissure etc. in being used for.
Radix Notoginseng cures mainly the dissipating blood stasis hemostasis, subduing swelling and relieving pain.Be used for various inside and outside hemorrhage, breast ventral spine pain, tumbling and swelling.
Radix Glycyrrhizae, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Poria, dysuria; The edema distension; The phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; The seminal emission nebulousurine.
Rhizoma Corydalis is invigorated blood circulation, promoting the circulation of QI, pain relieving.Be used for the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Endoconcha Sepiae, dehumidifying, antacid, skin ulcer is held back in hemostasis, and the acid regurgitation that treats for stomachache is told, nosebleed, hematemesis, has blood in stool, bleeding not during menses, amenorrhea due to blood depletion, the stomachache lump in the abdomen, the intermittent fever of deficiency type dysentery, skin ulcer is rotted in the erosion of the vulva.
Semen daturae extractum, anticholinergic agent is removed smooth muscle spasm, suppresses glandular secretion.Be used for gastric and duodenal ulcers, gastrointestinal tract, kidney, biliary colic etc.
Yet Clinical results shows that above-mentioned medical material is to treatment gastritis and the not good enough or inefficacy of peptic ulcer effect.
Summary of the invention
The objective of the invention is to overcome above-mentioned technical deficiency, a kind of treatment gastritis of effective raising cure rate and American cockroach medicament composition of peptic ulcer and preparation method thereof are provided.
The object of the invention is realized through following technical scheme: a kind of American cockroach medicament composition of treating gastritis and peptic ulcer; Said pharmaceutical composition mainly is made up of American-cockroach-extract, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Radix Glycyrrhizae, Poria, Rhizoma Corydalis, Endoconcha Sepiae, the mixed effective ingredient mixture that gets of Semen daturae extractum; By weight, its proportioning is: American-cockroach-extract: the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: Semen daturae extractum=0.8~1.2g: 1~10g: 1~10g: 0.5~6g: 0.25~6g: 0.25~10g: 0.5~6g: 0.83~6g: 5~60mg.Optimum ratio is: American-cockroach-extract: the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: Semen daturae extractum=1g: 4.5g: 5.5g: 3.2g: 2.8g: 4.3g: 3.7g: 0.83g: 17mg.
Said pharmaceutical composition also comprises purified water and glycerol, and in the effective ingredient mixture of 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800~1200ml: 4~6ml.The proportioning of preferred version is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
The method for preparing of the American cockroach medicament composition of treatment gastritis and peptic ulcer may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder, subsequent use;
B, immersion: add the water of 3~5 times of amounts according to the coarse powder of every 100kg, immersion made the coarse powder mixed liquor in 0.5~2 hour under 70~78 ℃ temperature conditions, and is subsequent use; Wherein, preferred version is: the amount that adds entry is 4 times of amounts, and soak time is 1 hour, and soaking temperature is 74 ℃;
C, three extractions: the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and when the coarse powder mixed liquor was carried out extracting the first time, extraction time was 7~9 hours; Behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5~7 hours; Behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3~5 hours, makes three times extracting solution respectively, and is subsequent use;
D, filtration for the first time: three times extracting solution are merged mixing, filter then and make one-level filtrating, subsequent use;
E, concentrated for the first time: relative density was 1.05~1.25 one-level concentrated solution when one-level filtrating was concentrated into 70~90 ℃, and is subsequent use;
F, alcoholization are handled: in the one-level concentrated solution, add the ethanol that concentration is 93~97%w/w gradually, and fully stir, make it contain the alcohol amount and reach till 45~55%; Insulation is 20~40 minutes under 70~90 ℃ temperature conditions; Left standstill then 10~14 hours, and made solution of alcoholized, subsequent use;
G, filtration for the second time: solution of alcoholized is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating, and is subsequent use;
H, the second time concentrate: after secondary filtrating was carried out the ethanol recycling, relative density is 1.15~1.30 secondary concentrated solution when being concentrated into 70~90 ℃, and was subsequent use;
The preparation of i, unguentum: the secondary concentrated solution is concentrated into the unguentum of moisture≤25~35% under condition of normal pressure, promptly gets American-cockroach-extract-containing, subsequent use;
2., weighing: by American-cockroach-extract: the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: the weight ratio of Semen daturae extractum=0.8~1.2g: 1~10g: 1~10g: 0.5~6g: 0.25~6g: 0.25~10g: 0.5~6g: 0.83~6g: 5~60mg is carried out weighing, and is subsequent use;
3., decoct: the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Endoconcha Sepiae powder are ground into fine powder, and it is subsequent use to cross 80 mesh sieves; With Radix Glycyrrhizae decocte with water three times, add 4~6 times of amounts of water preceding twice at every turn, decocted 2~4 hours, after once add 3~5 times of amounts of water, decocted 1~3 hour, the decocting liquid after then three times being decocted filters, filtrating merges, and is subsequent use; With the Radix Paeoniae Alba, Rhizoma Corydalis, Poria decocte with water twice, add 3~5 times of amounts of water at every turn, decocted 2~4 hours for the first time, decocted 1~3 hour for the second time, then the decocting liquid after twice decoction is filtered, filtrating merges, and is subsequent use; Twice filtrating is merged, filter through sheet frame then, be concentrated into 1000ml, add fine powder and Semen daturae extractum then, stir, it is subsequent use to make the decoction mixed liquor;
4., mixing active ingredients: with American-cockroach-extract and decoct mixed liquor mixing merging, stir, make the effective ingredient mixture, subsequent use;
5., patent medicine: according to the effective ingredient mixture: purified water: glycerol=1000g: 800~1200ml: 4~6ml; Stir, normal temperature drying to 800~1200ml is ground into fine powder then, has both got patent medicine.
Method for preparing of the present invention is simple, has given full play to the effect of American-cockroach-extract, has effectively improved the curative effect to gastritis and peptic ulcer.
The specific embodiment
The specific embodiment below in conjunction with embodiment is done further to specify to foregoing of the present invention again:
A kind of American cockroach medicament composition of treating gastritis and peptic ulcer; Said pharmaceutical composition mainly is made up of American-cockroach-extract, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Radix Glycyrrhizae, Poria, Rhizoma Corydalis, Endoconcha Sepiae, the mixed effective ingredient mixture that gets of Semen daturae extractum; By weight, its proportioning is: American-cockroach-extract: the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: Semen daturae extractum=0.8~1.2g: 1~10g: 1~10g: 0.5~6g: 0.25~6g: 0.25~10g: 0.5~6g: 0.83~6g: 5~60mg.Optimum ratio is: American-cockroach-extract: the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: Semen daturae extractum=1g: 4.5g: 5.5g: 3.2g: 2.8g: 4.3g: 3.7g: 0.83g: 17mg.
Said pharmaceutical composition also comprises purified water and glycerol, and in the effective ingredient mixture of 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800~1200ml: 4~6ml.The proportioning of preferred version is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
The method for preparing of the American cockroach medicament composition of treatment gastritis and peptic ulcer may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder, subsequent use;
B, immersion: add the water of 3~5 times of amounts according to the coarse powder of every 100kg, immersion made the coarse powder mixed liquor in 0.5~2 hour under 70~78 ℃ temperature conditions, and is subsequent use; Wherein, preferred version is: the amount that adds entry is 4 times of amounts, and soak time is 1 hour, and soaking temperature is 74 ℃;
C, three extractions: the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and when the coarse powder mixed liquor was carried out extracting the first time, extraction time was 7~9 hours; Behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5~7 hours; Behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3~5 hours, makes three times extracting solution respectively, and is subsequent use;
D, filtration for the first time: three times extracting solution are merged mixing, filter then and make one-level filtrating, subsequent use;
E, concentrated for the first time: relative density was 1.05~1.25 one-level concentrated solution when one-level filtrating was concentrated into 70~90 ℃, and is subsequent use;
F, alcoholization are handled: in the one-level concentrated solution, add the ethanol that concentration is 93~97%w/w gradually, and fully stir, make it contain the alcohol amount and reach till 45~55%; Insulation is 20~40 minutes under 70~90 ℃ temperature conditions; Left standstill then 10~14 hours, and made solution of alcoholized, subsequent use;
G, filtration for the second time: solution of alcoholized is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating, and is subsequent use;
H, the second time concentrate: after secondary filtrating was carried out the ethanol recycling, relative density is 1.15~1.30 secondary concentrated solution when being concentrated into 70~90 ℃, and was subsequent use;
The preparation of i, unguentum: the secondary concentrated solution is concentrated into the unguentum of moisture≤25~35% under condition of normal pressure, promptly gets American-cockroach-extract-containing, subsequent use;
2., weighing: by American-cockroach-extract: the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: the weight ratio of Semen daturae extractum=0.8~1.2g: 1~10g: 1~10g: 0.5~6g: 0.25~6g: 0.25~10g: 0.5~6g: 0.83~6g: 5~60mg is carried out weighing, and is subsequent use;
3., decoct: the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Endoconcha Sepiae powder are ground into fine powder, and it is subsequent use to cross 80 mesh sieves; With Radix Glycyrrhizae decocte with water three times, add 4~6 times of amounts of water preceding twice at every turn, decocted 2~4 hours, after once add 3~5 times of amounts of water, decocted 1~3 hour, the decocting liquid after then three times being decocted filters, filtrating merges, and is subsequent use; With the Radix Paeoniae Alba, Rhizoma Corydalis, Poria decocte with water twice, add 3~5 times of amounts of water at every turn, decocted 2~4 hours for the first time, decocted 1~3 hour for the second time, then the decocting liquid after twice decoction is filtered, filtrating merges, and is subsequent use; Twice filtrating is merged, filter through sheet frame then, be concentrated into 1000ml, add fine powder and Semen daturae extractum then, stir, it is subsequent use to make the decoction mixed liquor;
4., mixing active ingredients: with American-cockroach-extract and decoct mixed liquor mixing merging, stir, make the effective ingredient mixture, subsequent use;
5., patent medicine: according to the effective ingredient mixture: purified water: glycerol=1000g: 800~1200ml: 4~6ml; Stir, normal temperature drying to 800~1200ml is ground into fine powder then, has both got patent medicine.
Embodiment 1
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours; Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.05~1.08 (70 ℃), adding concentration was the ethanol of 93%w/w; Make that to become to contain alcohol amount be 40%, 70 ℃ of insulated and stirred 20 minutes, left standstill 10 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15~1.18 (70 ℃); Normal pressure is concentrated into the cream of moisture≤25%, promptly gets American-cockroach-extract-containing, and is subsequent use; By American-cockroach-extract: the weight ratio of the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: Semen daturae extractum=0.8g: 1g: 1g: 0.5g: 0.25g: 0.25g: 0.5g: 0.83g: 5mg is carried out weighing, and is subsequent use; The Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Endoconcha Sepiae powder are ground into fine powder, and it is subsequent use to cross 80 mesh sieves; With Radix Glycyrrhizae decocte with water three times, add 4 times of amounts of water preceding twice at every turn, decocted 2 hours, after once add 3 times of amounts of water, decocted 1 hour, the decocting liquid after then three times being decocted filters, filtrating merges, and is subsequent use; With the Radix Paeoniae Alba, Rhizoma Corydalis, Poria decocte with water twice, add 3 times of amounts of water at every turn, decocted 2 hours for the first time, decocted 1 hour for the second time, then the decocting liquid after twice decoction is filtered, filtrating merges, and is subsequent use; Twice filtrating is merged, filter through sheet frame then, be concentrated into 1000ml, add fine powder and Semen daturae extractum then, stir, it is subsequent use to make the decoction mixed liquor; With American-cockroach-extract and decoction mixed liquor mixing merging, stir, make the effective ingredient mixture, subsequent use; Press the effective ingredient mixture then: purified water: glycerol=1000g: 800ml: 4ml, add purified water and glycerol, stir, normal temperature drying is ground into fine powder then to 800ml, has both got patent medicine.
Embodiment 2
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours; Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.05~1.08 (70 ℃), adding concentration was the ethanol of 93%w/w; Make that to become to contain alcohol amount be 40%, 70 ℃ of insulated and stirred 20 minutes, left standstill 10 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15~1.18 (70 ℃); Normal pressure is concentrated into the cream of moisture≤25%, promptly gets American-cockroach-extract-containing, and is subsequent use; By American-cockroach-extract: the weight ratio of the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: Semen daturae extractum=1.2g: 10g: 10g: 6g: 6g: 10g: 6g: 6g: 60mg is carried out weighing, and is subsequent use; The Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Endoconcha Sepiae powder are ground into fine powder, and it is subsequent use to cross 80 mesh sieves; With Radix Glycyrrhizae decocte with water three times, add 6 times of amounts of water preceding twice at every turn, decocted 4 hours, after once add 5 times of amounts of water, decocted 3 hours, the decocting liquid after then three times being decocted filters, filtrating merges, and is subsequent use; With the Radix Paeoniae Alba, Rhizoma Corydalis, Poria decocte with water twice, add 5 times of amounts of water at every turn, decocted 4 hours for the first time, decocted 3 hours for the second time, then the decocting liquid after twice decoction is filtered, filtrating merges, and is subsequent use; Twice filtrating is merged, filter through sheet frame then, be concentrated into 1000ml, add fine powder and Semen daturae extractum then, stir, it is subsequent use to make the decoction mixed liquor; With American-cockroach-extract and decoction mixed liquor mixing merging, stir, make the effective ingredient mixture, subsequent use; Press the effective ingredient mixture then: purified water: glycerol=1000g: 1200ml: 6ml, add purified water and glycerol, stir, normal temperature drying is ground into fine powder then to 1200ml, has both got patent medicine.
Embodiment 3
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours; Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.05~1.08 (70 ℃), adding concentration was the ethanol of 93%w/w; Make that to become to contain alcohol amount be 40%, 70 ℃ of insulated and stirred 20 minutes, left standstill 10 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15~1.18 (70 ℃); Normal pressure is concentrated into the cream of moisture≤25%, promptly gets American-cockroach-extract-containing, and is subsequent use; By American-cockroach-extract: the weight ratio of the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: Semen daturae extractum=1g: 4.5g: 5.5g: 3.2g: 2.8g: 4.3g: 3.7g: 0.83g: 17mg is carried out weighing, and is subsequent use; The Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Endoconcha Sepiae powder are ground into fine powder, and it is subsequent use to cross 80 mesh sieves; With Radix Glycyrrhizae decocte with water three times, add 5 times of amounts of water preceding twice at every turn, decocted 3 hours, after once add 4 times of amounts of water, decocted 2 hours, the decocting liquid after then three times being decocted filters, filtrating merges, and is subsequent use; With the Radix Paeoniae Alba, Rhizoma Corydalis, Poria decocte with water twice, add 4 times of amounts of water at every turn, decocted 3 hours for the first time, decocted 2 hours for the second time, then the decocting liquid after twice decoction is filtered, filtrating merges, and is subsequent use; Twice filtrating is merged, filter through sheet frame then, be concentrated into 1000ml, add fine powder and Semen daturae extractum then, stir, it is subsequent use to make the decoction mixed liquor; With American-cockroach-extract and decoction mixed liquor mixing merging, stir, make the effective ingredient mixture, subsequent use; Press the effective ingredient mixture then: purified water: glycerol=1000g: 1000ml: 5ml, add purified water and glycerol, stir, normal temperature drying is ground into fine powder then to 1000ml, has both got patent medicine.
Embodiment 4
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours; Merge three times extracting solution, filter, when filtrating was concentrated into relative density and is 1.05~1.08 (70 ℃), adding concentration was the ethanol of 93%w/w; Make that to become to contain alcohol amount be 40%, 70 ℃ of insulated and stirred 20 minutes, left standstill 10 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15~1.18 (70 ℃); Normal pressure is concentrated into the cream of moisture≤25%, promptly gets American-cockroach-extract-containing, and is subsequent use; By American-cockroach-extract: the weight ratio of the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: Semen daturae extractum=0.9g: 4.2g: 5g: 6g: 1.8g: 1.3g: 2.7g: 1.3g: 7mg is carried out weighing, and is subsequent use; The Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Endoconcha Sepiae powder are ground into fine powder, and it is subsequent use to cross 80 mesh sieves; With Radix Glycyrrhizae decocte with water three times, add 4.2 times of amounts of water preceding twice at every turn, decocted 2.6 hours, after once add 3.4 times of amounts of water, decocted 1.3 hours, the decocting liquid after then three times being decocted filters, filtrating merges, and is subsequent use; With the Radix Paeoniae Alba, Rhizoma Corydalis, Poria decocte with water twice, add 3.5 times of amounts of water at every turn, decocted 2.5 hours for the first time, decocted 1.6 hours for the second time, then the decocting liquid after twice decoction is filtered, filtrating merges, and is subsequent use; Twice filtrating is merged, filter through sheet frame then, be concentrated into 1000ml, add fine powder and Semen daturae extractum then, stir, it is subsequent use to make the decoction mixed liquor; With American-cockroach-extract and decoction mixed liquor mixing merging, stir, make the effective ingredient mixture, subsequent use; Press the effective ingredient mixture then: purified water: glycerol=1000g: 900ml: 5.5ml, add purified water and glycerol, stir, normal temperature drying is ground into fine powder then to 900ml, has both got patent medicine.
Test Example: the clinical testing data of gastritis and peptic ulcer patient cure rate
One, physical data:
Gastritis and peptic ulcer patient number see each table for details, and wherein the gastritis sufferer is about 58%, and the peptic ulcer patient is about 42%, meets diagnostic criteria.Be divided into treatment group and matched group at random, the men and women does not wait, 1~55 years old age; Two groups of patient ages, sex and courses of disease are through statistical procedures, and difference does not have the significance meaning, has comparability.
Two, Therapeutic Method:
The treatment group: this programme medicine, oral, the 0.8~1.2g that is grown up a time, child three years old is with 0.3~0.5g next time, and three years old with last 0.8~1g, three times on the one.
Matched group: bismuth potassium citrate, oral.Be grown up one time 1,3 times on the one; Or 2 times on the one, sooner or later respectively obey 2.
Three, clinical testing data (see table 1,2, n number of delegates wherein, percentages is taked to round up and kept 2 significant digits)
Table 1: two groups of curative effects relatively
Figure GSA00000115028900091
Table 2: two groups of 30 days curative effects relatively
Group n 30 days healing patient numbers 30 days cure rates (%)
The treatment group 79 69 89.90
Matched group 70 55 78.57
Comprehensive conclusion: visible by above-mentioned clinical data, treatment group curative effect obviously is superior to matched group.
Gastritis and peptic ulcer are common clinicals, can occur in any age, and the characteristics of outbreak are repeatedly arranged.The generation of above-mentioned disease is relevant with multiple factor, and common have infection, immunity, zinc deficiency or the like.Medicines such as single clothes Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae) are a kind of medicines that is usually used in treating above-mentioned disease, and certain curative effect is arranged.Periplaneta americana is a kind of insecticide, is commonly called as Blatta seu periplaneta, and body contains the various active composition; Its extract main component is polyalcohols and peptide class active substance, confirms to have promotion epithelial cell, granulation tissue growth through pharmacological research, promotes wound repair; The effect of enhance immunity, but do not have antibacterial action, American-cockroach-extract uses with medicine collocation such as single clothes Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae)s; Not only can infection, can promote the chronic ulcer tissue reparation simultaneously, improve ulcer healing rate; Shorten the ulcer healing time, it is more effective that both share the above-mentioned disease of treatment.

Claims (6)

1. American cockroach medicament composition of treating gastritis and peptic ulcer; It is characterized in that: said pharmaceutical composition mainly is made up of American-cockroach-extract, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Radix Glycyrrhizae, Poria, Rhizoma Corydalis, Endoconcha Sepiae, the mixed effective ingredient mixture that gets of Semen daturae extractum; By weight, its proportioning is: American-cockroach-extract: the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: Semen daturae extractum=0.8~1.2g: 1~10g: 1~10g: 0.5~6g: 0.25~6g: 0.25~10g: 0.5~6g: 0.83~6g: 5~60mg.
2. according to the American cockroach medicament composition of said treatment gastritis of claim 1 and peptic ulcer; It is characterized in that: said by American-cockroach-extract, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Radix Glycyrrhizae, Poria, Rhizoma Corydalis, Endoconcha Sepiae, the mixed effective ingredient mixture that gets of Semen daturae extractum; By weight, its proportioning is: American-cockroach-extract: the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: Semen daturae extractum=1g: 4.5g: 5.5g: 3.2g: 2.8g: 4.3g: 3.7g: 0.83g: 17mg.
3. according to the American cockroach medicament composition of said treatment gastritis of claim 1 and peptic ulcer; It is characterized in that: said pharmaceutical composition is made up of American-cockroach-extract, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Radix Glycyrrhizae, Poria, Rhizoma Corydalis, Endoconcha Sepiae, the mixed effective ingredient mixture that gets of Semen daturae extractum and purified water and glycerol; In the effective ingredient mixture of 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800~1200ml: 4~6ml.
4. according to the American cockroach medicament composition of said treatment gastritis of claim 3 and peptic ulcer; It is characterized in that: said effective ingredient mixture in 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
5. according to the method for preparing of the American cockroach medicament composition of said treatment gastritis of claim 3 and peptic ulcer, it is characterized in that: said method for preparing may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder, subsequent use;
B, immersion: add the water of 3~5 times of amounts according to the coarse powder of every 100kg, immersion made the coarse powder mixed liquor in 0.5~2 hour under 70~78 ℃ temperature conditions, and is subsequent use;
C, three extractions: the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and when the coarse powder mixed liquor was carried out extracting the first time, extraction time was 7~9 hours; Behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5~7 hours; Behind the water that adds 2~4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3~5 hours, makes three times extracting solution respectively, and is subsequent use;
D, filtration for the first time: three times extracting solution are merged mixing, filter then and make one-level filtrating, subsequent use;
E, concentrated for the first time: relative density was 1.05~1.25 one-level concentrated solution when one-level filtrating was concentrated into 70~90 ℃, and is subsequent use;
F, alcoholization are handled: in the one-level concentrated solution, add the ethanol that concentration is 93~97%w/w gradually, and fully stir, make it contain the alcohol amount and reach till 45~55%; Insulation is 20~40 minutes under 70~90 ℃ temperature conditions; Left standstill then 10~14 hours, and made solution of alcoholized, subsequent use;
G, filtration for the second time: solution of alcoholized is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating, and is subsequent use;
H, the second time concentrate: after secondary filtrating was carried out the ethanol recycling, relative density is 1.15~1.30 secondary concentrated solution when being concentrated into 70~90 ℃, and was subsequent use;
The preparation of i, unguentum: the secondary concentrated solution is concentrated into the unguentum of moisture≤25~35% under condition of normal pressure, promptly gets American-cockroach-extract-containing, subsequent use;
2., weighing: by American-cockroach-extract: the Radix Paeoniae Alba: the Pseudobulbus Bletillae (Rhizoma Bletillae): Radix Notoginseng: Radix Glycyrrhizae: Poria: Rhizoma Corydalis: Endoconcha Sepiae: the weight ratio of Semen daturae extractum=0.8~1.2g: 1~10g: 1~10g: 0.5~6g: 0.25~6g: 0.25~10g: 0.5~6g: 0.83~6g: 5~60mg is carried out weighing, and is subsequent use;
3., decoct: the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Endoconcha Sepiae powder are ground into fine powder, and it is subsequent use to cross 80 mesh sieves; With Radix Glycyrrhizae decocte with water three times, add 4~6 times of amounts of water preceding twice at every turn, decocted 2~4 hours, after once add 3~5 times of amounts of water, decocted 1~3 hour, the decocting liquid after then three times being decocted filters, filtrating merges, and is subsequent use; With the Radix Paeoniae Alba, Rhizoma Corydalis, Poria decocte with water twice, add 3~5 times of amounts of water at every turn, decocted 2~4 hours for the first time, decocted 1~3 hour for the second time, then the decocting liquid after twice decoction is filtered, filtrating merges, and is subsequent use; Twice filtrating is merged, filter through sheet frame then, be concentrated into 1000ml, add fine powder and Semen daturae extractum then, stir, it is subsequent use to make the decoction mixed liquor;
4., mixing active ingredients: with American-cockroach-extract and decoct mixed liquor mixing merging, stir, make the effective ingredient mixture, subsequent use;
5., patent medicine: according to the effective ingredient mixture: the weight ratio of purified water: glycerol=1000g: 800~1200ml: 4~6ml adds purified water and glycerol, stirs, and normal temperature drying to 800~1200ml is ground into fine powder then, both patent medicine.
6. according to the method for preparing of the American cockroach medicament composition of said treatment gastritis of claim 5 and peptic ulcer, it is characterized in that: amount of water is 4 times of amounts among the said step b, and soak time is 1 hour, and soaking temperature is 74 ℃.
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