CN101822696B - Medicine composite for treating burn and scald and preparation method thereof - Google Patents
Medicine composite for treating burn and scald and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composite for treating burn and scald, which consists of the mixure of American cockroach extractive and active constituents of pberetima and flies. The proportioning, by weight percent, is the American cockroach extractive to the pberetima to the flies equals to 100 to 10-100 to 10-100. The preparation method of the medicine composite for treating burn and scald comprises the following steps: extracting the American cockroach extractive, extracting of pberetima and the the active constituents of the flies, and mixing the extractive and the active constituents to prepare the medicine. The invention gives full play to the action of the American cockroach extractive, effectively improves the efficacy of treating burn and scald, has the advantages of simple preparation method, convenient use, short heating time, little toxic and side effect and is a new medicine worth of generalization.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of pharmaceutical composition of treating burn and scald and preparation method thereof.
Background technology
It is documented that periplaneta americana is the maximum insecticide of volume in the Blattidae, originates in South America; Periplaneta americana is the traditional Chinese medicines material, is used as medicine its property plug salty in the mouth with dry and bright adult; Poisonous, acid is arranged, functions such as dissipating blood stasis, removing food stagnancy, detoxifcation, diuretic, detumescence are arranged; Curing mainly infantile malnutrition, tonsillitis, health enclosed mass, carbuncle skin ulcer swells and ache and Scolopendra, venom etc.
In recent years along with science and technology constantly develops, through discovering that for many years the periplaneta americana epidermis contains sclerotin and chitin, elements such as bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium; Muscle hydrolysis 13 seed amino acids; Its alcohol extract has the obvious suppression effect to cancerous cell, and cardiovascular disease is had tangible curative effect.In addition, health storage vitamin B
1, B
2, nicotinic acid and ascorbic acid etc., lymph contain trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc.All contain ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.Clinical main application has: treat infantile malnutrition, control the carbuncle pyogenic infections from tumour or sore, control the Scolopendra wound, control innominate toxic swelling, control the worm venom.But also have periplaneta americana and medical herbs compatibility auxiliary treatment colon cancer.American-cockroach-extract can be controlled hepatitis B, and extract A T-2 preparation can cure mainly primary hepatocarcinoma, cardiovascular disease etc.
Notification number is CN 100525781C; Name is called " American-cockroach-extract, contain pharmaceutical composition of this extract and preparation method thereof " and publication number is CN1943600A; It is two with the American-cockroach-extract relevant patent documentations of applicant in application in 2006 that name is called " pharmaceutical composition and the new purposes thereof that contain periplaneta americana and ethanol extraction thereof "; It discloses the method for preparing and the part medical usage of American-cockroach-extract; In recent years, along with the further research to American-cockroach-extract, American-cockroach-extract has obtained further development in purposes pharmaceutically.
Burn and scald is common unexpected injury in the life, and boiling water, the burn and scald that rolls medicated porridge, deep fat, heat steam are the things that regular meeting takes place.The weight of position, area size and the burn and scald of the main root root of the order of severity of burn and scald burn and scald is judged.Burn and scald is in women's head-ornaments portion, though or not in women's head-ornaments portion, the burn and scald area is big, the degree of depth is dark, all belong to severe patient.To some burn and scald,, just can not cause bad consequence if handle in time.At present, the existing medicine that is used to treat burn and scald still is a lot, like JINGWANHONG, silver-colored zinc MEBO etc.Yet, tend to suppurate with regard to present existing Drug therapy burn and scald, and healing time is long, wound healing stays scar slowly, easily.
In sum, existing medicine still has unsatisfactory part for the treatment burn and scald.For this reason, the invention provides a kind of new pharmaceutical composition that is used to treat burn and scald.
Summary of the invention
The objective of the invention is to: overcome above-mentioned deficiency of the prior art, a kind of pharmaceutical composition and preparation method thereof of treatment burn and scald of effective raising cure rate is provided.
The object of the invention is realized through following technical scheme: a kind of pharmaceutical composition of treating burn and scald is provided, it is characterized in that: the main component of said pharmaceutical composition and mass parts thereof are such as shown in down: 100 parts of American-cockroach-extracts; 10～100 parts of Pheretimas; 10～100 parts of flies.
The proportioning of one of preferred version of the pharmaceutical composition of above-mentioned treatment burn and scald is: 100 parts of American-cockroach-extracts; 50 parts of Pheretimas; 50 parts of flies.
Two proportioning of the preferred version of the pharmaceutical composition of above-mentioned treatment burn and scald is: 100 parts of American-cockroach-extracts; 80 parts of Pheretimas; 50 parts of flies.
The preparation of drug combination method of above-mentioned treatment burn and scald may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., with exsiccant Pheretima, fly coarse crushing, decocte with water is extracted three times, adds 4～8 times of water gagings for the first time, temperature was extracted 8 hours at 70 ℃～90 ℃; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.10～1.20 (80 ℃), add 92～98% ethanol; Make that to become to contain alcohol amount be 45～55%, 70～90 ℃ of following insulated and stirred 25～35 minutes, left standstill 10～14 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 20～40 minutes, be chilled to room temperature, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, after filtrating is boiled 20～40 minutes, again through the autoclave sterilization postcooling to room temperature, promptly get patent medicine.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
At the autoclave sterilization of above-mentioned steps described in 3. is under 115 ℃～127 ℃ of temperature, pressure are the condition of 0.05Mpa～0.15Mpa, to carry out sterilization, and sterilization time is 25～35 minutes.
In sum; The preparation of drug combination method that is used to treat burn and scald provided by the present invention is simple; And given full play to the effect of American-cockroach-extract; Effectively improved curative effect to burn and scald, and easy to use, wound healing is fast, toxic and side effects is little, is a kind of new medicine that is worthy to be popularized.
The specific embodiment
Do further to specify below in conjunction with the embodiment specific embodiments of the invention:
The main component of the pharmaceutical composition of treatment burn and scald provided by the present invention and mass parts ratio thereof are: 100 parts of American-cockroach-extracts; 10～100 parts of Pheretimas; 10～100 parts of flies.
The proportioning of one of preferred version of the pharmaceutical composition of above-mentioned treatment burn and scald is: 100 parts of American-cockroach-extracts; 50 parts of Pheretimas; 50 parts of flies.
Two proportioning of the preferred version of the pharmaceutical composition of above-mentioned treatment burn and scald is: 100 parts of American-cockroach-extracts; 80 parts of Pheretimas; 50 parts of flies.
The preparation of drug combination method of above-mentioned treatment burn and scald may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤25%～35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., with exsiccant Pheretima, fly coarse crushing, decocte with water is extracted three times, adds 4～8 times of water gagings for the first time, temperature was extracted 8 hours at 70 ℃～90 ℃; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.10～1.20 (80 ℃), add 92～98% ethanol; Make that to become to contain alcohol amount be 45～55%, 70～90 ℃ of following insulated and stirred 25～35 minutes, left standstill 10～14 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 20～40 minutes, be chilled to room temperature, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, after filtrating is boiled 20～40 minutes, again through the autoclave sterilization postcooling to room temperature, promptly get patent medicine.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
At the autoclave sterilization of above-mentioned steps described in 3. is under 115 ℃～127 ℃ of temperature, pressure are the condition of 0.05Mpa～0.15Mpa, to carry out sterilization, and sterilization time is 25～35 minutes.
Embodiment 1:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 50 parts of Pheretimas; 50 parts of flies.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.05 (70 ℃); Adding concentration is the ethanol of 93%w/w, makes that to become to contain the alcohol amount be 45%, 70 ℃ of insulated and stirred 20 minutes; Left standstill 10 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.20 (70 ℃), normal pressure is concentrated into the unguentum of moisture≤25%; According to unguentum: the ratio of purified water: glycerol=1000g: 800ml: 4ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With exsiccant Pheretima, fly coarse crushing, decocte with water is extracted three times, adds 4 times of water gagings for the first time, and temperature was extracted 8 hours at 70 ℃; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.10 (80 ℃), add 92% ethanol; Make that to become to contain alcohol amount be 45%, 70 ℃ of following insulated and stirred 25 minutes, left standstill 10 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 20 minutes, be chilled to room temperature, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, after filtrating was boiled 20 minutes, through 115 ℃, pressure was 0.05Mpa, sterilizes 25 minutes, is chilled to room temperature, promptly gets patent medicine again.
Embodiment 2:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 80 parts of Pheretimas; 50 parts of flies.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 500Kg water, soaks after 2 hours, and temperature is extracted three times about 78 ℃, 9 hours for the first time; For the second time add water 400Kg, extracted 7 hours; Add water 400Kg for the third time, extracted 5 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.25 (90 ℃); Adding concentration is the ethanol of 97%w/w, makes that to become to contain the alcohol amount be 55%, 90 ℃ of insulated and stirred 40 minutes; Left standstill 14 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.25 (90 ℃), normal pressure is concentrated into the unguentum of moisture≤35%; According to unguentum: the ratio of purified water: glycerol=1000g: 1200ml: 6ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With exsiccant Pheretima, fly coarse crushing, decocte with water is extracted three times, adds 8 times of water gagings for the first time, and temperature was extracted 8 hours at 90 ℃; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.20 (80 ℃), add 98% ethanol; Make that to become to contain alcohol amount be 55%, 90 ℃ of following insulated and stirred 35 minutes, left standstill 14 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.25 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 40 minutes, be chilled to room temperature, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, after filtrating was boiled 40 minutes, through 127 ℃, pressure was 0.15Mpa, sterilizes 35 minutes, is chilled to room temperature, promptly gets patent medicine again.
Embodiment 3:
The prescription that is adopted is: 100 parts of the big Lian extracts in continent; 10 parts of Pheretimas; 100 parts of flies.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 400Kg water, soaks after 1 hour, and temperature is extracted three times about 74 ℃, 8 hours for the first time; For the second time add water 300Kg, extracted 6 hours; Add water 300Kg for the third time, extracted 4 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.15 (80 ℃); Adding concentration is the ethanol of 95%w/w, makes that to become to contain the alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes; Left standstill 12 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.25 (80 ℃), normal pressure is concentrated into the unguentum of moisture≤30%; According to unguentum: the ratio of purified water: glycerol=1000g: 1000ml: 5ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With exsiccant Pheretima, fly coarse crushing, decocte with water is extracted three times, adds 6 times of water gagings for the first time, and temperature was extracted 8 hours at 80 ℃; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.10 (80 ℃), add 95% ethanol; Make that to become to contain alcohol amount be 50%, 80 ℃ of following insulated and stirred 30 minutes, left standstill 12 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 30 minutes, be chilled to room temperature, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, after filtrating was boiled 35 minutes, through 121 ℃, pressure was 0.1Mpa, sterilizes 30 minutes, is chilled to room temperature, promptly gets patent medicine again.
Embodiment 4:
The prescription that is adopted is: 100 parts of the big Lian extracts in continent; 100 parts of Pheretimas; 10 parts of flies.
Method for preparing is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 380Kg water, soaks after 0.8 hour, and temperature is extracted three times about 74 ℃, 7.5 hours for the first time; For the second time add water 280Kg, extracted 5 hours; Add water 280Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.2 (80 ℃); Adding concentration is the ethanol of 95%w/w, makes that to become to contain the alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes; Left standstill 11 hours, and discarded the upper strata oils and fats, lower floor's medical filtration; Filtrate recycling ethanol, being evaporated to relative density is 1.20 (80 ℃), normal pressure is concentrated into the unguentum of moisture≤30%; According to unguentum: the ratio of purified water: glycerol=1000g: 1100ml: 6ml adds purified water and glycerol in unguentum, stirs, and through plate-and-frame filtration, after filtrating is boiled 30 minutes, is chilled to room temperature, promptly gets American-cockroach-extract, and is subsequent use; With exsiccant Pheretima, fly coarse crushing, decocte with water is extracted three times, adds 7 times of water gagings for the first time, and temperature was extracted 8 hours at 90 ℃; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 1.15 (80 ℃), add 96% ethanol; Make that to become to contain alcohol amount be 52%, 80 ℃ of following insulated and stirred 32 minutes, left standstill 12 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.22 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 30 minutes, be chilled to room temperature, subsequent use; With stirring after above-mentioned two kinds of extracts mixing, through plate-and-frame filtration, after filtrating was boiled 30 minutes, through 121 ℃, pressure was 0.1Mpa, sterilizes 30 minutes, is chilled to room temperature, promptly gets patent medicine again.
The pharmaceutical composition of treatment burn and scald provided by the present invention can be processed various ways such as unguentum, tablet, suppository, capsule, is beneficial to satisfy different patients' medication custom.
The clinical testing data of burn and scald cure rate:
One, patient's classified data:
Burn and scald patient 100 examples meet diagnostic criteria.Be divided into treatment group and matched group at random, 50 examples are organized in treatment, male's 28 examples, women's 22 examples, 16～40 years old age; Matched group 50 examples, male's 28 examples, women's 22 examples, 16～40 years old age.Two groups of patient ages, sex and courses of disease are through statistical procedures, and difference does not have the significance meaning, has comparability.
Two, Therapeutic Method:
Treatment group: get unguentum, external application, twice on the one according to drug prepared of the present invention.
Matched group: get the common drug silver zinc MEBO of treatment burn and scald, external application, twice on the one.
Three, curative effect comparative result:
Table 1 is depicted as two groups of curative effects relatively, and wherein 50 examples are organized in treatment, cure 48 examples, and cure rate is 96.00%, and total effective rate is 100%; Matched group 50 examples are cured 35 examples, and cure rate is 70.00%, and total effective rate is 94.00%.Table 2 is depicted as two groups of 7 days curative effects relatively, treats in 7 days, and treatment group cure rate is 82.00%, and the matched group cure rate is 50.00%.This shows that treatment group curative effect obviously is superior to matched group.(n number of delegates in table 1 and the table 2)
Table 1
Table 2
| Group | n | 7 days healing patient numbers | 7 days cure rates (%) |
| The treatment group | 50 | 41 | 82.00 |
| Matched group | 50 | 25 | 50.00 |
Four, conclusion (of pressure testing):
Silver zinc MEBO is a kind of medicine that is usually used in the burn and scald treatment, and certain curative effect is arranged.Periplaneta americana is a kind of insecticide, is commonly called as Blatta seu periplaneta, and body contains the various active composition; Its extract main component is polyalcohols and peptide class active substance, confirms effect with enhance immunity through pharmacological research, but does not have antibacterial action; The medicine that American-cockroach-extract and Herba Ephedrae are processed not only can infection; Simultaneously can promote the quick rehabilitation of burn and scald, improve the burn and scald cure rate, shorten the burn and scald healing time.Comparing data shows, the curative effect that this medicine is used to treat burn and scald obviously is superior to medicine silver zinc MEBO commonly used.
Though done to describe in detail in conjunction with the specific embodiment specific embodiments of the invention, should not be construed as is to qualification of the present invention.In the protection domain that claims limited, various modifications that those skilled in the art can make without creative work or distortion still belong to the protection domain of this patent.
Claims (5)
1. pharmaceutical composition of treating burn and scald is characterized in that: each crude drug of said pharmaceutical composition and mass parts thereof are such as shown in down:
100 parts of American-cockroach-extracts;
10～100 parts of Pheretimas;
10～100 parts of flies;
Said preparation of drug combination method may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: with the water that adds 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time, carry out the second time then and extract, extraction time is 5～7 hours; Behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time, extract for the third time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrating;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the filtrating of the one-level in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that in step e, makes gradually; And fully stir; Making it contain the alcohol amount reaches till 45%～55%; Insulation is 20～40 minutes under 70 ℃～90 ℃ temperature conditions, leaves standstill then 10～14 hours, makes solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrating;
H, the second time concentrate: after the filtrating of the secondary in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the unguentum that the secondary concentrated solution among the step h is concentrated into moisture≤35% under condition of normal pressure;
J, extract preparation: according to unguentum: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml adds purified water and glycerol in unguentum, stir, through plate-and-frame filtration; After filtrating is boiled 30 minutes; Be chilled to room temperature, promptly get American-cockroach-extract, subsequent use;
2., with exsiccant Pheretima, fly coarse crushing, decocte with water is extracted three times, adds 4～8 times of water gagings for the first time, temperature was extracted 8 hours at 70 ℃～90 ℃; For the second time add 3 times of water gagings, extracted 6 hours; Add 3 times of water gagings for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrating is concentrated into relative density and is 80 ℃ 1.10～1.20, add 92～98% ethanol; Make that to become to contain alcohol amount be 45～55%, 70～90 ℃ of following insulated and stirred 25～35 minutes, left standstill 10～14 hours, discard the upper strata oils and fats; Lower floor's medical filtration, filtrate recycling ethanol is evaporated to relative density when being 80 ℃ 1.20～1.25, and normal pressure is concentrated into the cream of moisture≤30%; Through plate-and-frame filtration, after filtrating is boiled 20～40 minutes, be chilled to room temperature, subsequent use;
3., with step 1. with step in 2. prepared two kinds of extracts mix and stir, through plate-and-frame filtration, after filtrating is boiled 20～40 minutes, again through the autoclave sterilization postcooling to room temperature, promptly get patent medicine.
2. the pharmaceutical composition of treatment burn and scald according to claim 1 is characterized in that: amount of water is 4 times of amounts among the said step b, and soak time is 1 hour, and soaking temperature is 74 ℃.
3. the pharmaceutical composition of treatment burn and scald according to claim 1; It is characterized in that: said step 3. in autoclave sterilization be under 115 ℃～127 ℃ of temperature, pressure are the condition of 0.05Mpa～0.15Mpa, to carry out sterilization, sterilization time is 25～35 minutes.
4. according to the pharmaceutical composition of claim 1,2 or 3 described treatment burn and scald, it is characterized in that:
Each crude drug of said pharmaceutical composition and mass parts thereof are such as shown in down:
100 parts of American-cockroach-extracts;
50 parts of Pheretimas;
50 parts of flies.
5. according to the pharmaceutical composition of claim 1,2 or 3 described treatment burn and scald, it is characterized in that: each crude drug of said pharmaceutical composition and mass parts thereof are such as shown in down:
100 parts of American-cockroach-extracts;
80 parts of Pheretimas;
50 parts of flies.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101825075A CN101822696B (en) | 2010-05-25 | 2010-05-25 | Medicine composite for treating burn and scald and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101825075A CN101822696B (en) | 2010-05-25 | 2010-05-25 | Medicine composite for treating burn and scald and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101822696A CN101822696A (en) | 2010-09-08 |
| CN101822696B true CN101822696B (en) | 2012-05-30 |
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| EP3111947B1 (en) * | 2015-06-30 | 2020-12-09 | Sichuan Gooddoctor Panxi Pharmaceutical Co., Ltd. | Periplaneta americana extract or periplaneta americana medicinal powder as well as preparation method thereof and application in preparation of a medicament used for preventing and treating radiation-induced damages |
| CN107812016B (en) * | 2017-11-23 | 2020-03-27 | 大理大学 | Periplaneta americana extract, preparation method and application thereof in immune regulation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100525781C (en) * | 2006-09-30 | 2009-08-12 | 耿福能 | American falx extract, medicinal composition containing it and its making method |
| CN1943600B (en) * | 2006-10-17 | 2010-05-12 | 耿福能 | Medicinal composition containing American cockroach and its ethanol extract and new use |
-
2010
- 2010-05-25 CN CN2010101825075A patent/CN101822696B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100525781C (en) * | 2006-09-30 | 2009-08-12 | 耿福能 | American falx extract, medicinal composition containing it and its making method |
| CN1943600B (en) * | 2006-10-17 | 2010-05-12 | 耿福能 | Medicinal composition containing American cockroach and its ethanol extract and new use |
Non-Patent Citations (1)
| Title |
|---|
| 曾凡举等.地龙浸出液治疗烧伤168例疗效观察.《国医论坛》.2001,第16卷(第1期),36. * |
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Application publication date: 20100908 Assignee: Sichuan Good Doctor Panxi Pharmaceutical Co., Ltd. Assignor: Geng Funeng Contract record no.: 2013510000088 Denomination of invention: Medicinal composition for treating burn and scald and its preparation Granted publication date: 20120530 License type: Exclusive License Record date: 20130905 |
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