CN101837018A - American cockroach medicinal composition for curing ulcers or ulcerative inflammation and preparation method thereof - Google Patents
American cockroach medicinal composition for curing ulcers or ulcerative inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an American cockroach medicinal composition for curing ulcers or ulcerative inflammation. The medicinal composition is mainly prepared from an active ingredient mixture prepared by mixing an American cockroach extract and montmorillonite powder. The weight part ratio of the American cockroach extract to the montmorillonite powder is equal to 0.8-1.2:0.5-6. A preparation method of the American cockroach medicinal composition for curing the ulcers or the ulcerative inflammation comprises the following steps of: preparing the American cockroach extract, mixing active ingredients, and preparing medicaments. The medicinal composition has simple preparation method, fully exerts effects of the American cockroach extract, and has obvious effects of effectively curing diseases such as oral ulcers, recurrent aphthous ulcers, oral lichen planus, oral mucosal injury (behcet disease, herpes simplex, leukoplakia, discoid lupus erythematosus, hand-foot-and-mouth disease, scalds, chemotherapy, radiotherapy and the like) caused by various reasons, reflux esophagitis, eophageal ucers, radiation esophagitis, ulcerative colitis, radiation proctitis, and diarrhea, and hematochezia with mucosal injury, and the like.
Description
Technical field
The present invention relates to medical technical field, specifically relate to a kind of American cockroach medicament composition for the treatment of ulcer or ulcerative inflammation and preparation method thereof.
Background technology
It is documented that periplaneta americana is the insecticide of volume maximum in the Blattidae, originates in South America, periplaneta americana is traditional Chinese crude drug, is used as medicine its property plug salty in the mouth with dry and bright adult, poisonous, acid is arranged, functions such as dissipating blood stasis, removing food stagnancy, detoxifcation, diuretic, detumescence are arranged; Curing mainly infantile malnutrition, tonsillitis, health enclosed mass, carbuncle skin ulcer swells and ache and Scolopendra, venom etc.
Along with science and technology constantly develops, after years of research and found that in recent years the periplaneta americana epidermis contains sclerotin and chitin, elements such as bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium; Muscle hydrolysis 13 seed amino acids; Its alcohol extract has the obvious suppression effect to cancerous cell, and cardiovascular disease is had tangible curative effect.In addition, health storage vitamin B
1, B
2, nicotinic acid and ascorbic acid etc., lymph contain trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc.All contain ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.Clinical main application has: treat infantile malnutrition, control the carbuncle pyogenic infections from tumour or sore, control the Scolopendra wound, control innominate toxic swelling, control the worm venom.But also have periplaneta americana and medical herbs compatibility auxiliary treatment colon cancer.American-cockroach-extract can be controlled hepatitis B, and extract A T-2 preparation can cure mainly primary hepatocarcinoma, cardiovascular disease etc.
Notification number is CN 100525781C, name is called " American-cockroach-extract; contain pharmaceutical composition of this extract and preparation method thereof " and publication number is CN1943600A, it is two with the American-cockroach-extract relevant patent documentations of applicant in application in 2006 that name is called " pharmaceutical composition and the new purposes thereof that contain periplaneta americana and ethanol extraction thereof ", it discloses the preparation method and the part medical usage of American-cockroach-extract, in recent years, along with the further research to American-cockroach-extract, American-cockroach-extract has obtained further development in purposes pharmaceutically.
It is that treatment is grown up and the acute and chronic diarrhoea of child at present that Montmorillonitum looses; And the adjuvant therapy medicaments that is used for the ache related symptom that esophagus, stomach, dudenal disease cause, the main component of its medicine is a Montmorillonitum, Montmorillonitum looses and to have lamellar structure and heterogeneity CHARGE DISTRIBUTION, and the toxin of the virus in the digestive tract, pathogenic bacteria and generation thereof is had fixing, adsorption; Gastrointestinal mucosal there is covering power, and by mutually combining, from quality and quantity two aspect reparations, improve the defense function of mucosal barrier, has balance normal flora and local analgesic effect attack factor with mucous glycoprotein; Montmorillonitum looses and not to enter blood circulation, and together with institute fixedly attack factor excrete with digestive tract self wriggling; Do not influence X-ray examination, do not change the stool color, do not change normal enterokinesia.
It is not good enough that yet Montmorillonitum is dispersed in the curative effect of the diarrhoea of oral mucosa infringement (Behcet disease, herpes simplex, white macula, discoid lupus erythematosus, hand-foot-mouth disease, scald, chemotherapy, radiotherapy etc.), reflux esophagitis that oral ulcer, its ulcer of recurrent Ah fluorine, oral lichen planus, a variety of causes are caused, esophageal ulcer, radiation esophagitis, ulcerative colitis, radiation rectitis, the infringement of companion's mucosa, disease such as have blood in stool, even inefficacy, generally speaking, the effective cure rate that uses Montmorillonitum to loose separately is about 65～85%.
Summary of the invention
The objective of the invention is to overcome above-mentioned technical deficiency, American cockroach medicament composition of a kind of effective cure rate obvious results treatment ulcer or ulcerative inflammation and preparation method thereof is provided.
Purpose of the present invention is achieved through the following technical solutions: a kind of American cockroach medicament composition for the treatment of oral ulcer, described pharmaceutical composition mainly is made up of American-cockroach-extract and the diffusing mixed effective ingredient mixture that gets of Montmorillonitum, by weight, its proportioning is: American-cockroach-extract: Montmorillonitum looses=0.8～1.2: 0.5～6.Optimum ratio is: American-cockroach-extract: Montmorillonitum looses=1: 0.55.
Described pharmaceutical composition also comprises purified water and glycerol, and in the American-cockroach-extract-containing and the diffusing effective ingredient mixture of Montmorillonitum of 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800～1200ml: 4～6ml.The proportioning of preferred version is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
The preparation method of the American cockroach medicament composition of treatment ulcer or ulcerative inflammation may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder, standby;
B, immersion: add the water of 3～5 times of amounts according to the coarse powder of every 100kg, under 70～78 ℃ temperature conditions, soak and made the coarse powder mixed liquor in 0.5～2 hour, standby; Wherein, preferred version is: the amount that adds entry is 4 times of amounts, and soak time is 1 hour, and soaking temperature is 74 ℃;
C, three extractions: the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and when the coarse powder mixed liquor was carried out extracting the first time, extraction time was 7～9 hours; Carry out the second time then behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5～7 hours; Extract for the third time behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3～5 hours, makes three times extracting solution respectively, and is standby;
D, filtration for the first time: three times extracting solution are merged mixing, filter then and make one-level filtrate, standby;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when one-level filtrate was concentrated into 70～90 ℃, and is standby;
F, alcoholization are handled: add the ethanol that concentration is 93～97%w/w gradually in the one-level concentrated solution, and fully stir, make it contain the alcohol amount and reach till 45～55%, under 70～90 ℃ temperature conditions, be incubated 20～40 minutes, left standstill then 10～14 hours, and made solution of alcoholized, standby;
G, filtration for the second time: solution of alcoholized is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate, and is standby;
H, the second time concentrate: after secondary filtrate was carried out the ethanol recycling, relative density is 1.15～1.30 secondary concentrated solution when being concentrated into 70～90 ℃, and was standby;
The preparation of i, unguentum: the secondary concentrated solution is concentrated into the unguentum of moisture≤25～35% under condition of normal pressure, promptly gets American-cockroach-extract-containing, standby;
2., mixing active ingredients: according to American-cockroach-extract: loose=0.8～1.2: 0.5～6 weight part ratio of Montmorillonitum carries out weighing, mixing, makes the effective ingredient mixture, and is standby;
3., patent medicine: according to the effective ingredient mixture: the weight ratio of purified water: glycerol=1000g: 800～1200ml: 4～6ml adds purified water and glycerol in the effective ingredient mixture, stir, through plate-and-frame filtration, after filtrate is boiled 30 minutes, be distributed into 100ml/ bottle or 50ml/ bottle, through the autoclave sterilization sterilization, be chilled to room temperature again, promptly get patent medicine.
The autoclave sterilization sterilization of described step in 3. is to carry out sterilization under 115～127 ℃ of temperature, pressure are the condition of 0.05～0.15Mpa, and sterilization time is 25～35 minutes.
Preparation method of the present invention is simple, given full play to the effect of American-cockroach-extract, effective cure rate effect of the diarrhoea of oral mucosa infringement (Behcet disease, herpes simplex, white macula, discoid lupus erythematosus, hand-foot-mouth disease, scald, chemotherapy, radiotherapy etc.), the reflux esophagitis that oral ulcer, its ulcer of recurrent Ah fluorine, oral lichen planus, a variety of causes are caused, esophageal ulcer, radiation esophagitis, ulcerative colitis, radiation rectitis, the infringement of companion's mucosa, disease such as have blood in stool is remarkable.
The specific embodiment
The specific embodiment below in conjunction with embodiment is described in further detail foregoing of the present invention again:
A kind of American cockroach medicament composition for the treatment of oral ulcer, described pharmaceutical composition mainly is made up of American-cockroach-extract and the diffusing mixed effective ingredient mixture that gets of Montmorillonitum, by weight, its proportioning is: American-cockroach-extract: Montmorillonitum looses=0.8～1.2: 0.5～6.Optimum ratio is: American-cockroach-extract: Montmorillonitum looses=1: 0.55.
Described pharmaceutical composition also comprises purified water and glycerol, and in the American-cockroach-extract-containing and the diffusing effective ingredient mixture of Montmorillonitum of 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800～1200ml: 4～6ml.The proportioning of preferred version is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
The preparation method of the American cockroach medicament composition of treatment ulcer or ulcerative inflammation may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder, standby;
B, immersion: add the water of 3～5 times of amounts according to the coarse powder of every 100kg, under 70～78 ℃ temperature conditions, soak and made the coarse powder mixed liquor in 0.5～2 hour, standby; Wherein, preferred version is: the amount that adds entry is 4 times of amounts, and soak time is 1 hour, and soaking temperature is 74 ℃;
C, three extractions: the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and when the coarse powder mixed liquor was carried out extracting the first time, extraction time was 7～9 hours; Carry out the second time then behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5～7 hours; Extract for the third time behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3～5 hours, makes three times extracting solution respectively, and is standby;
D, filtration for the first time: three times extracting solution are merged mixing, filter then and make one-level filtrate, standby;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when one-level filtrate was concentrated into 70～90 ℃, and is standby;
F, alcoholization are handled: add the ethanol that concentration is 93～97%w/w gradually in the one-level concentrated solution, and fully stir, make it contain the alcohol amount and reach till 45～55%, under 70～90 ℃ temperature conditions, be incubated 20～40 minutes, left standstill then 10～14 hours, and made solution of alcoholized, standby;
G, filtration for the second time: solution of alcoholized is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate, and is standby;
H, the second time concentrate: after secondary filtrate was carried out the ethanol recycling, relative density is 1.15～1.30 secondary concentrated solution when being concentrated into 70～90 ℃, and was standby;
The preparation of i, unguentum: the secondary concentrated solution is concentrated into the unguentum of moisture≤25～35% under condition of normal pressure, promptly gets American-cockroach-extract-containing, standby;
2., mixing active ingredients: according to American-cockroach-extract: loose=0.8～1.2: 0.5～6 weight part ratio of Montmorillonitum carries out weighing, mixing, makes the effective ingredient mixture, and is standby;
3., patent medicine: according to the effective ingredient mixture: the weight ratio of purified water: glycerol=1000g: 800～1200ml: 4～6ml adds purified water and glycerol in the effective ingredient mixture, stir, through plate-and-frame filtration, after filtrate is boiled 30 minutes, be distributed into 100ml/ bottle or 50ml/ bottle, through the autoclave sterilization sterilization, be chilled to room temperature again, promptly get patent medicine.
The autoclave sterilization sterilization of described step in 3. is to carry out sterilization under 115～127 ℃ of temperature, pressure are the condition of 0.05～0.15Mpa, and sterilization time is 25～35 minutes.
Embodiment 1
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.05～1.08 (70 ℃), adding concentration is the ethanol of 93%w/w, make that to become to contain alcohol amount be 40%, 70 ℃ of insulated and stirred 20 minutes, left standstill 10 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.15～1.18 (70 ℃), normal pressure is concentrated into the cream of moisture≤25%, press American-cockroach-extract: the weight part ratio of Montmorillonitum diffusing=0.8: 0.5, add the diffusing mixed effective ingredient mixture of Montmorillonitum, press the effective ingredient mixture then: purified water: glycerol=1000g: 800ml: 4ml, add purified water and glycerol, stir, through plate-and-frame filtration, after filtrate is boiled 30 minutes, be distributed into 100ml/ bottle or 50ml bottle, in temperature is 115 ℃, and pressure is to carry out autoclave sterilization under the condition of 0.05Mpa, and sterilization time is 25 minutes, be chilled to room temperature, promptly get patent medicine.
Embodiment 2
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 500Kg water, soaks after 2 hours, and temperature is extracted three times about 78 ℃, 9 hours for the first time; For the second time add water 400Kg, extracted 7 hours; Add water 400Kg for the third time, extracted 5 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.22～1.25 (90 ℃), adding concentration is the ethanol of 97%w/w, make that to become to contain alcohol amount be 55%, 90 ℃ of insulated and stirred 40 minutes, left standstill 14 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.27～1.30 (90 ℃), normal pressure is concentrated into the cream of moisture≤35%, press American-cockroach-extract: the weight part ratio of Montmorillonitum diffusing=1.2: 6, add the diffusing mixed effective ingredient mixture of Montmorillonitum, press the effective ingredient mixture then: purified water: glycerol=1000g: 1200ml: 6ml, add purified water and glycerol, stir, through plate-and-frame filtration, after filtrate is boiled 30 minutes, be distributed into 100ml/ bottle or 50ml bottle, in temperature is 127 ℃, and pressure is to carry out autoclave sterilization under the condition of 0.15Mpa, and sterilization time is 35 minutes, be chilled to room temperature, promptly get patent medicine.
Embodiment 3
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 400Kg water, soaks after 1 hour, and temperature is extracted three times about 74 ℃, 8 hours for the first time; For the second time add water 300Kg, extracted 6 hours; Add water 300Kg for the third time, extracted 4 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.10～1.20 (80 ℃), adding concentration is the ethanol of 95%w/w, make that to become to contain alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes, left standstill 12 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%, press American-cockroach-extract: the weight part ratio of Montmorillonitum diffusing=1: 0.55, add the diffusing mixed effective ingredient mixture of Montmorillonitum, press the effective ingredient mixture then: purified water: glycerol=1000g: 1000ml: 5ml, add purified water and glycerol, stir, through plate-and-frame filtration, after filtrate is boiled 30 minutes, be distributed into 100ml/ bottle or 50ml bottle, in temperature is 121 ℃, and pressure is to carry out autoclave sterilization under the condition of 0.1Mpa, and sterilization time is 30 minutes, be chilled to room temperature, promptly get patent medicine.
Embodiment 4
Implement according to the method described above, with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 420Kg water, soaks after 0.8 hour, and temperature is extracted three times about 76 ℃, 7.5 hours for the first time; For the second time add water 380Kg, extracted 5.5 hours; Add water 380Kg for the third time, extracted 3.5 hours; Merge three times extracting solution, filter, when filtrate is concentrated into relative density and is 1.06～1.09 (78 ℃), adding concentration is the ethanol of 94%w/w, make that to become to contain alcohol amount be 48%, 76 ℃ of insulated and stirred 35 minutes, left standstill 13 hours, discard the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.16～1.18 (76 ℃), normal pressure is concentrated into the cream of moisture≤28%, press American-cockroach-extract: the weight part ratio of Montmorillonitum diffusing=1.1: 0.52, add the diffusing mixed effective ingredient mixture of Montmorillonitum, press the effective ingredient mixture then: purified water: glycerol=1000g: 900ml: 5.5ml, add purified water and glycerol, stir, through plate-and-frame filtration, after filtrate is boiled 30 minutes, be distributed into 100ml/ bottle or 50ml bottle, in temperature is 124 ℃, and pressure is to carry out autoclave sterilization under the condition of 0.12Mpa, and sterilization time is 32 minutes, be chilled to room temperature, promptly get patent medicine.
The clinical trial example:
One, physical data:
Oral mucosa infringement (Behcet disease, herpes simplex, white macula, discoid lupus erythematosus, hand-foot-mouth disease, scald, chemotherapy, radiotherapy etc.), reflux esophagitis, esophageal ulcer, radiation esophagitis, patients of ulcerative colitis number that oral ulcer, its ulcer of recurrent Ah fluorine, oral lichen planus, a variety of causes cause see each table for details, meet diagnostic criteria.Be divided into treatment group and matched group at random, the men and women does not wait, 1～40 years old age; Patient's course of disease is many at 2～5 days, elder 10～15 days, two groups.Two groups of patient ages, sex and courses of disease are learned processing by statistics, and difference does not have the significance meaning, has comparability.
Two, Therapeutic Method:
The treatment group: this programme medicine, oral, the 0.8～1.2g that is grown up a time, child three years old is with 0.3～0.5g next time, and three years old with last 0.8～1g, three times on the one.
Matched group: Montmorillonitum looses, and is oral, a 0.4g, three times on the one.
Three, clinical testing data (see Table 1～16, n number of delegates wherein, percentages is taked to round up and kept 2 significant digits)
Test example one: the clinical testing data of oral ulcer patient's cure rate
Table 1: two groups of curative effects relatively
Table 2: two groups of 3 days curative effects relatively
| Group | ??n | 3 days healing patient numbers | 3 days cure rates (%) |
| The treatment group | ??69 | ??52 | ?75.36 |
| Matched group | ??63 | ??28 | ?44.44 |
Test example two: the clinical testing data of its ulcer patient cure rate of recurrent Ah fluorine
Table 3: two groups of curative effects relatively
Table 4: two groups of 3 days curative effects relatively
| Group | ??n | 3 days healing patient numbers | 3 days cure rates (%) |
| The treatment group | ??87 | ??62 | ?71.26 |
| Matched group | ??93 | ??21 | ?22.58 |
Test example three: the clinical testing data of oral lichen planus ulcer patient cure rate
Table 5: two groups of curative effects relatively
Table 6: two groups of 3 days curative effects relatively
| Group | ??n | 3 days healing patient numbers | 3 days cure rates (%) |
| The treatment group | ??78 | ??54 | ?69.23 |
| Matched group | ??84 | ??22 | ?26.19 |
Test example four: the clinical testing data of the oral mucosa infringement patient cure rate that reasons such as Behcet disease, herpes simplex, white macula, discoid lupus erythematosus, hand-foot-mouth disease, scald, chemotherapy, radiotherapy cause
Table 7: two groups of curative effects relatively
Table 8: two groups of 3 days curative effects relatively
| Group | ??n | 3 days healing patient numbers | 3 days cure rates (%) |
| The treatment group | ??79 | ??56 | ?70.89 |
| Matched group | ??76 | ??23 | ?30.26 |
Test example five: the clinical testing data of reflux esophagitis patient's cure rate
Table 9: two groups of curative effects relatively
Table 10: two groups of 3 days curative effects relatively
| Group | ??n | 3 days healing patient numbers | 3 days cure rates (%) |
| The treatment group | ??83 | ??64 | ?77.11 |
| Matched group | ??73 | ??18 | ?24.66 |
Test example six: the clinical testing data of esophageal ulcer patient's cure rate
Table 11: two groups of curative effects relatively
Table 12: two groups of 3 days curative effects relatively
| Group | ??n | 3 days healing patient numbers | 3 days cure rates (%) |
| The treatment group | ??93 | ??72 | ?77.42 |
| Matched group | ??69 | ??26 | ?37.68 |
Test example seven: the clinical testing data of radiation esophagitis patient's cure rate
Table 13: two groups of curative effects relatively
Table 14: two groups of 3 days curative effects relatively
| Group | ??n | 3 days healing patient numbers | 3 days cure rates (%) |
| The treatment group | ??106 | ??77 | ?72.64 |
| Matched group | ??86 | ??26 | ?30.23 |
Test example eight: the clinical testing data of patients of ulcerative colitis cure rate
Table 15: two groups of curative effects relatively
Table 16: two groups of 3 days curative effects relatively
| Group | ??n | 3 days healing patient numbers | 3 days cure rates (%) |
| The treatment group | ??91 | ??71 | ?78.02 |
| Matched group | ??69 | ??22 | ?31.88 |
Comprehensive conclusion: by above-mentioned clinical data as seen, treatment group curative effect obviously is better than matched group.
The diarrhoea of the infringement of oral mucosa that oral ulcer, its ulcer of recurrent Ah fluorine, oral lichen planus, a variety of causes cause (Behcet disease, herpes simplex, white macula, discoid lupus erythematosus, hand-foot-mouth disease, scald, chemotherapy, radiotherapy etc.), reflux esophagitis, esophageal ulcer, radiation esophagitis, ulcerative colitis, radiation rectitis, the infringement of companion's mucosa, disease such as have blood in stool are common clinicals, can occur in any age, the characteristics of outbreak are repeatedly arranged.The generation of above-mentioned disease is relevant with multiple factor, and common have infection, immunity, zinc deficiency or the like.It is a kind of medicine that is usually used in treating above-mentioned disease that Montmorillonitum looses, and certain curative effect is arranged.Periplaneta americana is a kind of insecticide, be commonly called as Blatta seu periplaneta, body contains the various active composition, its extract main component is polyalcohols and peptide class active substance, confirm to have promotion epithelial cell, granulation tissue growth through pharmacological research, promote wound repair, the effect of enhance immunity, but do not have antibacterial action, the collocation of loosing of American-cockroach-extract and Montmorillonitum is used, not only can infection, simultaneously can promote the chronic ulcer tissue reparation, improve ulcer healing rate, shorten the ulcer healing time, it is more effective that both share the above-mentioned disease of treatment.
Claims (7)
1. American cockroach medicament composition for the treatment of ulcer or ulcerative inflammation, it is characterized in that: described pharmaceutical composition mainly is made up of American-cockroach-extract and the diffusing mixed effective ingredient mixture that gets of Montmorillonitum, by weight, its proportioning is: American-cockroach-extract: Montmorillonitum looses=0.8～1.2: 0.5～6.
2. according to the American cockroach medicament composition of described treatment ulcer of claim 1 or ulcerative inflammation, it is characterized in that: described American-cockroach-extract and Montmorillonitum loose, and by weight, its proportioning is: American-cockroach-extract: Montmorillonitum looses=1: 0.55.
3. according to the American cockroach medicament composition of described treatment ulcer of claim 1 or ulcerative inflammation, it is characterized in that: described pharmaceutical composition also comprises purified water and glycerol, in the American-cockroach-extract-containing and the diffusing effective ingredient mixture of Montmorillonitum of 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 800～1200ml: 4～6ml.
4. according to the American cockroach medicament composition of the described treatment oral ulcer of claim 3, it is characterized in that: the described effective ingredient mixture that looses in the American-cockroach-extract-containing and the Montmorillonitum of 1000g weight, its proportioning is: effective ingredient mixture: purified water: glycerol=1000g: 1000ml: 5ml.
5. according to the preparation method of the American cockroach medicament composition of described treatment ulcer of claim 1 or ulcerative inflammation, it is characterized in that: described preparation method may further comprise the steps:
1., the preparation of American-cockroach-extract:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder, standby;
B, immersion: add the water of 3～5 times of amounts according to the coarse powder of every 100kg, under 70～78 ℃ temperature conditions, soak and made the coarse powder mixed liquor in 0.5～2 hour, standby;
C, three extractions: the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and when the coarse powder mixed liquor was carried out extracting the first time, extraction time was 7～9 hours; Carry out the second time then behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5～7 hours; Extract for the third time behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3～5 hours, makes three times extracting solution respectively, and is standby;
D, filtration for the first time: three times extracting solution are merged mixing, filter then and make one-level filtrate, standby;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when one-level filtrate was concentrated into 70～90 ℃, and is standby;
F, alcoholization are handled: add the ethanol that concentration is 93～97%w/w gradually in the one-level concentrated solution, and fully stir, make it contain the alcohol amount and reach till 45～55%, under 70～90 ℃ temperature conditions, be incubated 20～40 minutes, left standstill then 10～14 hours, and made solution of alcoholized, standby;
G, filtration for the second time: solution of alcoholized is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate, and is standby;
H, the second time concentrate: after secondary filtrate was carried out the ethanol recycling, relative density is 1.15～1.30 secondary concentrated solution when being concentrated into 70～90 ℃, and was standby;
The preparation of i, unguentum: the secondary concentrated solution is concentrated into the unguentum of moisture≤25～35% under condition of normal pressure, promptly gets American-cockroach-extract-containing, standby;
2., mixing active ingredients: according to American-cockroach-extract: loose=0.8～1.2: 0.5～6 weight part ratio of Montmorillonitum carries out weighing, mixing, makes the effective ingredient mixture, and is standby;
3., patent medicine: according to the effective ingredient mixture: the weight ratio of purified water: glycerol=1000g: 800～1200ml: 4～6ml adds purified water and glycerol in the effective ingredient mixture, stir, through plate-and-frame filtration, after filtrate is boiled 30 minutes, be distributed into 100ml/ bottle or 50ml/ bottle, through the autoclave sterilization sterilization, be chilled to room temperature again, promptly get patent medicine.
6. according to the preparation method of the American cockroach medicament composition of described treatment ulcer of claim 5 or ulcerative inflammation, it is characterized in that: amount of water is 4 times of amounts among the described step b, and soak time is 1 hour, and soaking temperature is 74 ℃.
7. according to the preparation method of the American cockroach medicament composition of described treatment ulcer of claim 5 or ulcerative inflammation, it is characterized in that: the autoclave sterilization sterilization of described step in 3. is to carry out sterilization under 115～127 ℃ of temperature, pressure are the condition of 0.05～0.15Mpa, and sterilization time is 25～35 minutes.
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