CN102302518B - Cockroach extractive and prepared oral care composition as well as preparation method and applications - Google Patents
Cockroach extractive and prepared oral care composition as well as preparation method and applications Download PDFInfo
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- CN102302518B CN102302518B CN2011102301071A CN201110230107A CN102302518B CN 102302518 B CN102302518 B CN 102302518B CN 2011102301071 A CN2011102301071 A CN 2011102301071A CN 201110230107 A CN201110230107 A CN 201110230107A CN 102302518 B CN102302518 B CN 102302518B
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Abstract
The invention provides a cockroach extractive and a prepared oral care composition as well as a preparation method and applications. The preparation of the cockroach extractive comprises the following steps: heating, refluxing and extracting coarse powder of dried cockroach with 70%-95% ethanol, filtering, and concentrating while decompressing to obtain a crude paste; carrying out oil-water separation on the crude paste; removing the sediment at the bottom layer and grease at the upper layer; collecting brown liquid medicine at the middle layer; then adding active carbon for decolorizing, filling to a macroporous resin column, and eluting with water; and collecting eluate, and concentrating while decompressing to obtain cockroach extractive refined paste. The oral care composition comprises 0.1-10% of cockroach extractive, 0.5-1.5% of carboxymethylcellulose, 15-25% of glycerin, 0.1-0.3% of methyl parahydroxybenzoate, 0.05-0.15% of propyl p-hydroxybenzoate, 0.3-1.0% of sodium lauryl sulfate, 35-45% of calcium hydrogen phosphate dihydrate, 3-8% of anhydrous dicalcium phosphate, 3-8% of silicon dioxide, 0.1-0.3% of saccharin, and 1.0-1.5% of essence. The oral care composition is used for preventing and treating gum bleeding, resisting inflammation, and repairing canker sore.
Description
Technical field
The invention belongs to cockroach and extract the pharmaceutical technology field, be specifically related to a kind of bioactive substance that from cockroach, extracts, be used to prepare oral care composition, said composition is used to prevent and treat gingival hemorrhage, antiinflammatory, reparation oral ulcer.
Background technology
Cockroach, having another name called periplaneta americana (being commonly called as Blatta seu periplaneta) is that volume is maximum in the Blattidae, becomes long 29-35 millimeters of polypide.The cockroach epidermis contains sclerotin and chitin; Elements such as bromine, zinc, nickel, manganese, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium; The muscle hydrolysis can get 13 seed amino acids; The plain B1 of also little in store life, B2, nicotinic acid and ascorbic acid etc. in the health contain trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc. in the lymph; All contain ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.Modern scientific research shows; Cockroach extractive has very strong biological activity; But also there is significant limitation in prior art for the application of cockroach extractive; The bioactive substance that cockroach extracts has antiinflammatory, repairs oral ulcer, the function of control gingival hemorrhage and fail to develop, so the cockroach extractive application potential awaits further development and utilization.
Summary of the invention
First purpose of the present invention is to provide a kind of cockroach extractive; Second purpose is to provide a kind of oral care composition that contains this cockroach extractive; The 3rd purpose is to provide a kind of method for preparing of this oral care composition; The 4th purpose is this oral care composition control gingival hemorrhage, the application in antiinflammatory, the reparation oral ulcer.
The present invention's first purpose is achieved in that described cockroach extractive is prepared by following method:
The dried worm of cockroach is ground into coarse powder, extracted 8～10 hours with 70%～95% alcohol heat reflux of 5～10 times of weight ratios, filtrating through be evaporated to relative density 1.0～1.2 thick cream; With thick cream impouring oil water separator, the purified water that adds 6～10 times of weight portions fully stirs, and leaves standstill 12～24 hours; Remove bottom precipitate and upper strata oils and fats, collect the brown medicinal liquid in middle level, add active carbon then; It is colourless to medicinal liquid fully to stir static 1～2 hour of back, and the decolouring medicinal liquid macroporous resin column of packing into is used water elution; Collect eluent, be evaporated to relative density 1.0～1.2 and get the smart cream of cockroach extractive.
Concentrating under reduced pressure temperature in the described cockroach extractive method for preparing is 60～80 ℃.
Macroporous resin column in the described cockroach extractive method for preparing is D101, D101-1, D1300 type macroporous resin column.
The present invention's second purpose is to realize like this; Described oral care composition contains 0.1～10% cockroach extractive, 0.5～1.5% carboxymethyl cellulose, 15～25% glycerol, 0.1～0.3% methyl parahydroxybenzoate, 0.05～0.15% propyl p-hydroxybenzoate, 0.3～1.0% sodium lauryl sulphate, 35～45% dicalcium phosphate dehydrate, 3～8% calcium phosphate dibasic anhydrouses, 3～8% silicon dioxide, 0.1～0.3% glucide, 1.0～1.5% essence.
Its prioritization scheme is: described oral care composition contains 0.1～5% cockroach extractive, 0.6～1.3% carboxymethyl cellulose, 18～22% glycerol, 0.15～0.25% methyl parahydroxybenzoate, 0.08～0.12% propyl p-hydroxybenzoate, 0.4～0.8% sodium lauryl sulphate, 38～42% dicalcium phosphate dehydrate, 4～6% calcium phosphate dibasic anhydrouses, 4～6% silicon dioxide, 0.15～0.25% glucide, 1.1～1.4% essence.
Further prioritization scheme is: described oral care composition contains 0.15～0.45% cockroach extractive, 0.8～1.1% carboxymethyl cellulose, 19～21% glycerol, 0.18～0.22% methyl parahydroxybenzoate, 0.09～0.11% propyl p-hydroxybenzoate, 0.5～0.7% sodium lauryl sulphate, 39～41% dicalcium phosphate dehydrate, 5% calcium phosphate dibasic anhydrous, 5% silicon dioxide, 0.18～0.23% glucide, 1.2～1.3% essence.
The 3rd purpose of the present invention is achieved in that by following these steps to preparation after the compositions proportioning: behind carboxymethyl cellulose and glycerol homodisperse, add purified water and fully be dissolved into colloid solution; Place after 10～12 hours; Add cockroach extractive, methyl parahydroxybenzoate, propyl p-hydroxybenzoate, sodium lauryl sulphate, dicalcium phosphate dehydrate, calcium phosphate dibasic anhydrous, silicon dioxide, glucide, essence, stir and become to be mixed into paste, promptly get oral care composition.
The 4th purpose of the present invention is achieved in that prepared oral care composition at the control gingival hemorrhage, with the application in antiinflammatory, the reparation oral ulcer.
The antiinflammatory that the present invention fully has the active component of cockroach extractive, the functional component of repairing oral ulcer, control gingival hemorrhage are brought into play, for people provide one type of new nontoxic oral care product.
The specific embodiment
Below in conjunction with embodiment the present invention is further described, but never in any form the present invention is limited, any change or improvement based on training centre of the present invention is done all belong to protection scope of the present invention.
Embodiment 1
Dried worm 1000g is ground into coarse powder with cockroach, extracted 8 hours with 70% alcohol heat reflux of 5 times of weight ratios, filtrating under 60 ℃, be evaporated to relative density 1.0～1.2 thick cream; With thick cream impouring oil water separator, the purified water that adds 6 times of weight portions fully stirs, and leaves standstill 12 hours; Remove bottom precipitate and upper strata oils and fats, collect the brown medicinal liquid in middle level, add active carbon then; It is colourless to medicinal liquid fully to stir static 1 hour of back, and the decolouring medicinal liquid D101 type macroporous resin column of packing into is used water elution; Collect eluent, be evaporated to relative density 1.0～1.2 and get the smart cream of cockroach extractive.
Embodiment 2
The dried worm of cockroach is ground into coarse powder, extracted 10 hours with 95% alcohol heat reflux of 10 times of weight ratios, filtrating under 80 ℃, be evaporated to relative density 1.0～1.2 thick cream; With thick cream impouring oil water separator, the purified water that adds 10 times of weight portions fully stirs, and leaves standstill 24 hours; Remove bottom precipitate and upper strata oils and fats, collect the brown medicinal liquid in middle level, add active carbon then; It is colourless to medicinal liquid fully to stir static 2 hours of back, and the decolouring medicinal liquid D101-1 type macroporous resin column of packing into is used water elution; Collect eluent, be evaporated to relative density 1.0～1.2 and get the smart cream of cockroach extractive.
Embodiment 3
Dried worm 1000g is ground into coarse powder with cockroach, be heated to 70 ℃ with 80% ethanol of 8 times of weight ratios and extract 9 hours times, filtrating through be evaporated to relative density 1.0～1.2 thick cream; Thick cream is imported oil water separator, and the purified water that adds 8 times of weight portions fully stirs, and leaves standstill 18 hours; Remove bottom precipitate and upper strata oils and fats; Collect the brown medicinal liquid in middle level, add active carbon then, it is colourless to medicinal liquid fully to stir static 1.5 hours of back; The decolouring medicinal liquid D1300 macroporous resin column of packing into use water elution, collects eluent, be evaporated to relative density 1.0～1.2 cockroach extractive essence cream.
Embodiment 4
The cockroach extractive that makes with embodiment 1 is a raw material, in total amount 1000g, behind carboxymethyl cellulose with 0.5% and 18% the glycerol homodisperse, adds purified water 100ml and fully is dissolved into colloid solution; Place after 10 hours; Cockroach extractive, 0.1% methyl parahydroxybenzoate, 0.05% propyl p-hydroxybenzoate, 0.3% sodium lauryl sulphate, 35% dicalcium phosphate dehydrate, 3% calcium phosphate dibasic anhydrous, 35% silicon dioxide, 0.1% glucide, 1.0% essence of adding 0.1%; Stir and become to be mixed into paste, promptly get oral care composition.
Embodiment 5
The cockroach extractive that makes with embodiment 2 is a raw material, in total amount 1000g, behind carboxymethyl cellulose with 1.5% and 22% the glycerol homodisperse, adds purified water 100ml and fully is dissolved into colloid solution; Place after 12 hours; Cockroach extractive, 0.3% methyl parahydroxybenzoate, 0.15% propyl p-hydroxybenzoate, 1.0% sodium lauryl sulphate, 45% dicalcium phosphate dehydrate, 8% calcium phosphate dibasic anhydrous, 8% silicon dioxide, 0.3% glucide, 1.5% essence of adding 10%; Stir and become to be mixed into paste, promptly get oral care composition.
Embodiment 6
The cockroach extractive that makes with embodiment 3 is a raw material, in total amount 1000g, behind carboxymethyl cellulose with 0.6% and 15% the glycerol homodisperse, adds purified water 100ml and fully is dissolved into colloid solution; Place after 11 hours; Cockroach extractive, 0.15% methyl parahydroxybenzoate, 0.08% propyl p-hydroxybenzoate, 0.4% sodium lauryl sulphate, 38% dicalcium phosphate dehydrate, 4% calcium phosphate dibasic anhydrous, 4% silicon dioxide, 0.15% glucide, 1.1% essence of adding 5%; Stir and become to be mixed into paste, promptly get oral care composition.
Embodiment 7
The cockroach extractive that makes with embodiment 2 is a raw material, in total amount 1000g, behind carboxymethyl cellulose with 1.3% and 25% the glycerol homodisperse, adds purified water 100ml and fully is dissolved into colloid solution; Place after 10.5 hours; Cockroach extractive, 0.25% methyl hydroxybenzoate, 0.12% propyl p-hydroxybenzoate, 0.8% sodium lauryl sulphate, 42% dicalcium phosphate dehydrate, 6% calcium phosphate dibasic anhydrous, 6% silicon dioxide, 0.25% glucide, 1.4% essence of adding 0.15%; Stir and become to be mixed into paste, promptly get oral care composition.
Embodiment 8
The cockroach extractive that makes with embodiment 1 is a raw material, in total amount 1000g, behind carboxymethyl cellulose with 0.8 and 19% the glycerol homodisperse, adds purified water 100ml and fully is dissolved into colloid solution; Place after 11.5 hours; Cockroach extractive, 0.18% methyl parahydroxybenzoate, 0.09% propyl p-hydroxybenzoate, 0.5% sodium lauryl sulphate, 39% dicalcium phosphate dehydrate, 5% calcium phosphate dibasic anhydrous, 5% silicon dioxide, 0.18% glucide, 1.2% essence of adding 0.45%; Stir and become to be mixed into paste, promptly get oral care composition.
Embodiment 9
The cockroach extractive that makes with embodiment 2 is a raw material, in total amount 1000g, behind carboxymethyl cellulose with 1.1% and 21% the glycerol homodisperse, adds purified water 100ml and fully is dissolved into colloid solution; Place after 12 hours; Cockroach extractive, 0.22% methyl parahydroxybenzoate, 0.11% propyl p-hydroxybenzoate, 0.7% sodium lauryl sulphate, 41% dicalcium phosphate dehydrate, 4% calcium phosphate dibasic anhydrous, 3% silicon dioxide, 0.23% glucide, 1.3% essence of adding 0.45%; Stir and become to be mixed into paste, promptly get oral care composition.
Claims (8)
1. cockroach extractive is characterized in that described cockroach extractive is prepared by following method:
The dried worm of cockroach is ground into coarse powder, extracted 8～10 hours with 70%～95% alcohol heat reflux of 5～10 times of weight ratios, filtrating through be evaporated to relative density 1.0～1.2 thick cream; With thick cream impouring oil water separator, the purified water that adds 6～10 times of weight portions fully stirs, and leaves standstill 12～24 hours; Remove bottom precipitate and upper strata oils and fats, collect the brown medicinal liquid in middle level, add active carbon then; It is colourless to medicinal liquid fully to stir static 1～2 hour of back, and the decolouring medicinal liquid macroporous resin column of packing into is used water elution; Collect eluent, be evaporated to relative density 1.0～1.2 and get the smart cream of cockroach extractive.
2. cockroach extractive according to claim 1 is characterized in that: the concentrating under reduced pressure temperature in the described cockroach extractive method for preparing is 60～80 ℃.
3. cockroach extractive according to claim 1 is characterized in that: the macroporous resin column in the described cockroach extractive method for preparing is D101, D101-1, D1300 type macroporous resin column.
4. oral care composition that contains the described cockroach extractive of claim 1; It is characterized in that: contain 0.1～10% cockroach extractive, 0.5～1.5% carboxymethyl cellulose, 15～25% glycerol, 0.1～0.3% methyl parahydroxybenzoate, 0.05～0.15% propyl p-hydroxybenzoate, 0.3～1.0% sodium lauryl sulphate, 35～45% dicalcium phosphate dehydrate, 3～8% calcium phosphate dibasic anhydrouses, 3～8% silicon dioxide, 0.1～0.3% glucide, 1.0～1.5% essence.
5. oral care composition according to claim 4; It is characterized in that: contain 0.1～5% cockroach extractive, 0.6～1.3% carboxymethyl cellulose, 18～22% glycerol, 0.15～0.25% methyl parahydroxybenzoate, 0.08～0.12% propyl p-hydroxybenzoate, 0.4～0.8% sodium lauryl sulphate, 38～42% dicalcium phosphate dehydrate, 4～6% calcium phosphate dibasic anhydrouses, 4～6% silicon dioxide, 0.15～0.25% glucide, 1.1～1.4% essence.
6. oral care composition according to claim 4; It is characterized in that: contain 0.15～0.45% cockroach extractive, 0.8～1.1% carboxymethyl cellulose, 19～21% glycerol, 0.18～0.22% methyl parahydroxybenzoate, 0.09～0.11% propyl p-hydroxybenzoate, 0.5～0.7% sodium lauryl sulphate, 39～41% dicalcium phosphate dehydrate, 5% calcium phosphate dibasic anhydrous, 5% silicon dioxide, 0.18～0.23% glucide, 1.2～1.3% essence.
7. the method for preparing of a claim 4,5 or 6 described oral care compositions, it is characterized in that by following these steps to preparation after the compositions proportioning: behind carboxymethyl cellulose and glycerol homodisperse, the adding purified water fully is dissolved into colloid solution; Place after 10～12 hours; Add cockroach extractive, methyl parahydroxybenzoate, propyl p-hydroxybenzoate, sodium lauryl sulphate, dicalcium phosphate dehydrate, calcium phosphate dibasic anhydrous, silicon dioxide, glucide, essence, stir and become to be mixed into paste, promptly get oral care composition.
8. a claim 1,2 or 3 each described cockroach extractives prevent gingival hemorrhage in preparation, and the application in the oral care composition of antiinflammatory, reparation oral ulcer.
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| CN2011102301071A CN102302518B (en) | 2011-08-12 | 2011-08-12 | Cockroach extractive and prepared oral care composition as well as preparation method and applications |
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| CN2011102301071A CN102302518B (en) | 2011-08-12 | 2011-08-12 | Cockroach extractive and prepared oral care composition as well as preparation method and applications |
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| CN102302518B true CN102302518B (en) | 2012-11-28 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104337843A (en) * | 2013-08-02 | 2015-02-11 | 成都百草和济科技有限公司 | Decolourized periplaneta americana extract as well as preparation method and application thereof |
| CN104523755B (en) * | 2014-10-08 | 2019-06-11 | 大理学院 | A kind of blattaria active component and its preparation method and application |
| CN104983744A (en) * | 2015-07-01 | 2015-10-21 | 重庆登康口腔护理用品股份有限公司 | Oral care composition containing periplaneta americana, oral care products and preparation methods of oral care composition and oral care products |
| CN107970199B (en) * | 2018-01-03 | 2021-05-07 | 昆明赛诺制药股份有限公司 | Toothpaste containing periplaneta americana refined extract |
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| CN1895217A (en) * | 2006-06-20 | 2007-01-17 | 廖言 | Use of blattaria extracts as additive in fine chemical products and its preparation |
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Owner name: YUNNAN TENGYAO PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: YUNNAN TENGCHONG PHARMACEUTICAL FACTORY |
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Address after: 679100 Tengchong County of Baoshan City, Yunnan Province town of Tengyue Tiancheng Community Park District No. 139 chicken wings Patentee after: Yunnan Teng pharmaceutical Limited by Share Ltd Address before: Guanghua Road 679100 Tengchong city of Yunnan province Baoshan County Tengyue Town Street No. 61 Patentee before: Yunnan Tengchong Pharmaceutical Factory |