CN110038061A - Sen Deng -4 ointment and preparation method thereof - Google Patents
Sen Deng -4 ointment and preparation method thereof Download PDFInfo
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- CN110038061A CN110038061A CN201910488860.7A CN201910488860A CN110038061A CN 110038061 A CN110038061 A CN 110038061A CN 201910488860 A CN201910488860 A CN 201910488860A CN 110038061 A CN110038061 A CN 110038061A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a kind of Sen Deng -4 ointment and preparation method thereof, which is prepared by stearic acid, albolene, monoglyceride, atoleine, triethanolamine, water phase, lauryl sodium sulfate, glyceride, preservative, azone, Sen Deng -4 extracting solution.Conventional oral anaesthetic is fabricated to dermatology's external preparation by new preparation work by novelty of the invention, for treating skin disease and using as skin care item, expands the use scope of drug.
Description
Technical field
The present invention relates to anaesthetic fields, and in particular to a kind of Sen Deng -4 ointment and preparation method thereof.
Background technique
Anaesthetic compound Sendeng-4 Soup is the clinically used antirheumatic drug of Mongolian medicine, is recorded in " Inner Mongol Mongolia patent drug standard ".It should
Medicine is made of 4 tastes, is respectively wood of shiny-leaved yellowhorn 15g, Fructus meliae toosendan 9g, cape jasmine 3g, myrobalan 3g by the sequence of monarch, have heat-clearing,
The function of dry yellow water, for treating the illnesss such as gout, arthritis, oedema, existing Chinese literature is reported in addition to traditional decoction,
There are also capsule, has no that other preparations are reported, also have no the document report of said preparation external application.
Summary of the invention
To solve the above problems, expanding making for drug the present invention provides a kind of Sen Deng -4 ointment and preparation method thereof
Use range.
To achieve the above object, the technical scheme adopted by the invention is as follows:
Sen Deng -4 ointment, the ointment is by stearic acid, albolene, monoglyceride, atoleine, triethanolamine, water phase, dodecyl
Sodium sulphate, glyceride, preservative, azone, Sen Deng -4 extracting solution are prepared.
Preferably, it is prepared by the raw material of following components:
Oily phase: 2.5g stearic acid, 1.25g albolene, 1.125g monoglyceride, 3.75g atoleine, 0.055g triethanolamine；
Water phase: 0.055g lauryl sodium sulfate, 2.5g glyceride, 0.125g preservative, 0.5g azone, 13.75ml Sen Deng -4
Extracting solution.
Preferably, it is prepared by the raw material of following components:
Oily phase: 2.5g stearic acid, 1.25g albolene, 1.125g monoglyceride, 3.75g atoleine, 0.055g triethanolamine；
Water phase: 0.055g lauryl sodium sulfate, 2.5g glyceride, 0.125g preservative, 0.5g azone, 13.75ml Sen Deng -4
Extracting solution.
Further, Sen Deng -4 extracting solution is prepared by the following method gained:
The ratio that wood of shiny-leaved yellowhorn, Fructus meliae toosendan, myrobalan, cape jasmine are 5:3:1:1 in mass ratio is mixed, is crushed, No. 1 sieve is crossed, weighs suitable
Amount, add 10 times of volumes water impregnate for 24 hours, filtering, take filtrate to get.
The present invention also provides the preparation methods of above-mentioned Sen Deng -4 ointment, include the following steps:
S1, each component is weighed by above-mentioned formula；
S2, water phase is mutually first heated separately to 85 degree with oil, stirs 20min, make it uniformly, is then added to oil phase slowly
In water phase, stirring and emulsifying 20min or so is cooled to room temperature out sample.
The invention has the following advantages:
Innovative is fabricated to dermatology's external preparation by new preparation work for conventional oral anaesthetic, for treating skin disease
It sick (inflammatory dermatoses such as eczema, dermatitis, acne, fungi and bacterium infection) and is used as skin care item, expands drug
Use scope.
Specific embodiment
The present invention is described in detail combined with specific embodiments below.Following embodiment will be helpful to the technology of this field
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill of this field
For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention
Protection scope.
In following embodiment, Sen Deng -4 extracting solution is prepared by the following method gained:
The ratio that wood of shiny-leaved yellowhorn, Fructus meliae toosendan, myrobalan, cape jasmine are 5:3:1:1 in mass ratio is mixed, is crushed, No. 1 sieve is crossed, weighs suitable
Amount, add 10 times of volumes water impregnate for 24 hours, filtering, take filtrate to get.
Embodiment 1
A kind of Sen Deng -4 ointment is prepared by the following method gained:
S1, it weighs: oily phase: 2.5g stearic acid, 1.25g albolene, 1.125g monoglyceride, 3.75g atoleine, 0.055g tri-
Ethanol amine；
Water phase: 0.055g lauryl sodium sulfate, 2.5g glyceride, 0.125g preservative, 0.5g azone, 13.75ml Sen Deng -4
Extracting solution.
S2, water phase is mutually first heated separately to 85 degree with oil, stirs 20min, make it uniformly, then mutually adds oily slowly
Enter into water phase, stirring and emulsifying 20min or so is cooled to room temperature out sample.
Embodiment 2
A kind of Sen Deng -4 ointment is prepared by the following method gained:
S1, it weighs: oily phase: 2.5g stearic acid, 1.25g albolene, 1.125g monoglyceride, 3.75g atoleine, 0.055g tri-
Ethanol amine；
Water phase: 0.055g lauryl sodium sulfate, 2.5g glyceride, 0.125g preservative, 0.5g azone, 13.75ml Sen Deng -4
Extracting solution.
S2, water phase is mutually first heated separately to 85 degree with oil, stirs 20min, make it uniformly, then mutually adds oily slowly
Enter into water phase, stirring and emulsifying 20min or so is cooled to room temperature out sample.
The resulting ointment of Example 1 and Example 2 of the present invention is that appearance is faint yellow, lotion exquisiteness, is had appropriate glutinous
Consistence is easy to be coated with；4000 r · min-130 min are centrifuged under revolving speed, observation has grease without layering demulsifying phenomenon；0 ℃,
40 DEG C of 30 d of placement are sampled respectively at 0,10,30 d and are observed, and do not occur phenomena such as being layered, crystallization is demulsified, is rancid, foreign odor；
As it can be seen that the resulting ointment stability of the present invention is good.
Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited to above-mentioned
Particular implementation, those skilled in the art can make a variety of changes or modify within the scope of the claims, this not shadow
Ring substantive content of the invention.In the absence of conflict, the feature in embodiments herein and embodiment can any phase
Mutually combination.
Claims (5)
1. Sen Deng -4 ointment, it is characterised in that: the ointment is by stearic acid, albolene, monoglyceride, atoleine, triethanolamine,
Water phase, lauryl sodium sulfate, glyceride, preservative, azone, Sen Deng -4 extracting solution are prepared.
2. Sen Deng -4 ointment as described in claim 1, it is characterised in that: be prepared by the raw material of following components:
Oily phase: 2.5g stearic acid, 1.25g albolene, 1.125g monoglyceride, 3.75g atoleine, 0.055g triethanolamine；
Water phase: 0.055g lauryl sodium sulfate, 2.5g glyceride, 0.125g preservative, 0.5g azone, 13.75ml Sen Deng -4
Extracting solution.
3. Sen Deng -4 ointment as described in claim 1, it is characterised in that: be prepared by the raw material of following components:
Oily phase: 2.5g stearic acid, 1.25g albolene, 1.125g monoglyceride, 3.75g atoleine, 0.055g triethanolamine；
Water phase: 0.055g lauryl sodium sulfate, 2.5g glyceride, 0.125g preservative, 0.5g azone, 13.75ml Sen Deng -4
Extracting solution.
4. Sen Deng -4 ointment as described in any one of claims 1-3, it is characterised in that: Sen Deng -4 extracting solution passes through following
Method preparation gained:
The ratio that wood of shiny-leaved yellowhorn, Fructus meliae toosendan, myrobalan, cape jasmine are 5:3:1:1 in mass ratio is mixed, is crushed, No. 1 sieve is crossed, weighs suitable
Amount, add 10 times of volumes water impregnate for 24 hours, filtering, take filtrate to get.
5. the preparation method of Sen Deng -4 ointment, characterized by the following steps:
S1, each component is weighed by formula described in claim 2-3；
S2, water phase is mutually first heated separately to 85 degree with oil, stirs 20min, make it uniformly, is then added to oil phase slowly
In water phase, stirring and emulsifying 20min is cooled to room temperature out sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910488860.7A CN110038061A (en) | 2019-06-06 | 2019-06-06 | Sen Deng -4 ointment and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910488860.7A CN110038061A (en) | 2019-06-06 | 2019-06-06 | Sen Deng -4 ointment and preparation method thereof |
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| Publication Number | Publication Date |
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| CN110038061A true CN110038061A (en) | 2019-07-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910488860.7A Pending CN110038061A (en) | 2019-06-06 | 2019-06-06 | Sen Deng -4 ointment and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772572A (en) * | 2019-11-29 | 2020-02-11 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Senden-4 lotion and preparation method thereof |
| CN111840116A (en) * | 2020-08-27 | 2020-10-30 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Senden-4 hyaluronic acid repairing and moisturizing mask and preparation method thereof |
Citations (3)
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|---|---|---|---|---|
| CN101066290A (en) * | 2007-06-12 | 2007-11-07 | 白岩 | Hongyao ointment and its prepn |
| CN107233368A (en) * | 2017-06-22 | 2017-10-10 | 广东药科大学 | One kind is drawn out the pus detumescence Chinese medicine external ointment and preparation method thereof |
| CN107929411A (en) * | 2017-12-22 | 2018-04-20 | 纳贡毕力格 | A kind of soft extract for treating grasserie and preparation method thereof |
-
2019
- 2019-06-06 CN CN201910488860.7A patent/CN110038061A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066290A (en) * | 2007-06-12 | 2007-11-07 | 白岩 | Hongyao ointment and its prepn |
| CN107233368A (en) * | 2017-06-22 | 2017-10-10 | 广东药科大学 | One kind is drawn out the pus detumescence Chinese medicine external ointment and preparation method thereof |
| CN107929411A (en) * | 2017-12-22 | 2018-04-20 | 纳贡毕力格 | A kind of soft extract for treating grasserie and preparation method thereof |
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| 成为亨特: ""藏医如何治疗"黄水症"？……"", 《HTTP://WWW.360DOC.COM/CONTENT/13/0207/20/5642174_264746505.SHTML》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772572A (en) * | 2019-11-29 | 2020-02-11 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Senden-4 lotion and preparation method thereof |
| CN111840116A (en) * | 2020-08-27 | 2020-10-30 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Senden-4 hyaluronic acid repairing and moisturizing mask and preparation method thereof |
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Application publication date: 20190723 |