CN107929411A - A kind of soft extract for treating grasserie and preparation method thereof - Google Patents
A kind of soft extract for treating grasserie and preparation method thereof Download PDFInfo
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- CN107929411A CN107929411A CN201711400175.1A CN201711400175A CN107929411A CN 107929411 A CN107929411 A CN 107929411A CN 201711400175 A CN201711400175 A CN 201711400175A CN 107929411 A CN107929411 A CN 107929411A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
A kind of soft extract for treating grasserie and preparation method thereof, mainly include following major ingredient, wood of shiny-leaved yellowhorn root (the drying branch or stem of Sapindaceae defoliation small arbor shiny-leaved yellowhorn), Fructus meliae toosendan (dry mature fruit of melia toosendan section deciduous tree melia toosendan), myrobalan (gentleman section deciduous tree myrobalan or fine hair myrobalan), cape jasmine (dry fruit of Rubiaceae evergreen shrubs cape jasmine), male sulphur (the sulfide-based mineral realgar of monoclinic system processed) and refined honey, major ingredient are formed according to mass fraction：5 20 parts of wood of shiny-leaved yellowhorn root, 3 12 parts of Fructus meliae toosendan, 14 parts of myrobalan, 14 parts of cape jasmine, 14 parts of male sulphur and refined honey, refined honey quality are 1 times 2.8 times of clear cream quality.The present invention is made of pure natural mongolian medicine, without side-effects, small to skin irritatin, and content is high, easy to carry, can smear at any time.
Description
Technical field
The present invention relates to a kind of soft extract for treating grasserie and preparation method thereof.
Background technology
Psoriasis, the common skin disease characterized by skin rashes, the surface covering multilayer silvery white scales of skin that peel off.Also known as " silver bits
Disease ", whole body can fall ill, and with scalp, it is relatively conventional that four limbs stretch side, aggravates in the winter time more.It is blue or green strong to be more common in Northern Part of China
Year people, the course of disease is longer, there is an easy tendency of recurrence, and some cases almost cannot be cured all one's life feature.Mongolian medicine thinks psoriasis because being extravesated blood
Caused by yellow water, promote pure and impure raw China, conditioning three, dry yellow water principle of reatment, depending on the state of an illness select ten five tastes cloud perfume (or spice) roc balls,
18 taste mercury balls, four taste wood of shiny-leaved yellowhorn soup, up to along roc bird ball, she and soup etc., divided with cow urine stirring Semen Abutili 4, realgar 1 is divided
Dissipate painting etc. outside【1】.Wherein ten five tastes cloud perfume (or spice) roc balls, 18 taste mercury balls, four taste wood of shiny-leaved yellowhorn soup are cooler in the nature, and Long-term Oral is easy
It is uncomfortable to there is alimentary canal, the symptom such as abdominal distension, indigestion；External application realgar is warm-natured, again, it is poisonous, although with can after cow urine stirring
Weaken toxicity, but it is safe to use not as processing, so also it is not recommended that long-term external application.
The content of the invention
The present invention takes orally external application in view of the above problems, providing a kind of medicine and being modified to, both can be easy to carry, on time
Treatment, and can not have to endure because of a kind of soft extract for treating grasserie for the side effect that Long-term taking medicine is brought and its preparation side
Method.
The invention mainly comprises following major ingredient：Wood of shiny-leaved yellowhorn root (the drying branch of Sapindaceae defoliation small arbor shiny-leaved yellowhorn or
Stem), Fructus meliae toosendan (dry mature fruit of melia toosendan section deciduous tree melia toosendan), myrobalan (gentleman section deciduous tree myrobalan or fine hair
Myrobalan), cape jasmine (dry fruit of Rubiaceae evergreen shrubs cape jasmine), (the sulfide-based mineral of monoclinic system processed are male for male sulphur
It is yellow) and refined honey.
Major ingredient is formed according to mass fraction：5-20 parts of wood of shiny-leaved yellowhorn root, 3-12 parts of Fructus meliae toosendan, 1-4 parts of myrobalan, 1-4 parts of cape jasmine,
Male sulphur 1-4 parts, 1 times -2.8 times that refined honey quality is clear cream quality.
The preparation method of the present invention is as follows：
(1) stock up：Wood of shiny-leaved yellowhorn root, Fructus meliae toosendan are selected, myrobalan, cape jasmine, processes to crush after male sulphur cleaning and is put into clean pot
It is interior, appropriate drinking water is added, medicinal material is covered, closing lid, when standing 12 is small；
(2) decoct：12 it is small when after, add the drinking water of 10 times of the mass fraction of medicinal material in step (1), be placed on warm fire
On decoct repeatedly 4 times, filtered through gauze, merging filtrate；
(3) concentrate：Filtrate is cooked by slow fire, slow boiling constantly stirs, 120 ° -150 ° of the temperature range of slow boiling, until being changed into
Dope, closes fire when water evaporation is complete, closing lid is stood, and it is cooled off naturally, forms clear cream；Clear cream is taken out and is smashed, and with stainless
The sieve of 120 mesh of steel pulverizer is crushed, and forms medicinal powder；
(4) cream is received：Qinghuo reagent, adds refined honey, and is stirred continuously and plunders the offscum on liquid level, and relative density control exists
1.2g/cm3-1.4g/cm3。
(5) dispense：Soft extract fully let cool naturally after in aseptic subpackaged bag is fitted into, often packing band loading amount be 100g, fill
Measuring difference is《Chinese Pharmacopoeia version in 2015》Defined.
The present invention is external application soft extract, and when use takes according to the area in affected part is applied directly to affected part in right amount.2-3 on the one
It is secondary.
Compared with prior art, the present invention have the following advantages that：This ointment is made of pure natural mongolian medicine, without side-effects,
Small to skin irritatin, content is high, easy to carry, can smear at any time.
Embodiment
Embodiment 1
The invention mainly comprises following major ingredient：Wood of shiny-leaved yellowhorn root (the drying branch of Sapindaceae defoliation small arbor shiny-leaved yellowhorn or
Stem), Fructus meliae toosendan (dry mature fruit of melia toosendan section deciduous tree melia toosendan), myrobalan (gentleman section deciduous tree myrobalan or fine hair
Myrobalan), cape jasmine (dry fruit of Rubiaceae evergreen shrubs cape jasmine), (the sulfide-based mineral of monoclinic system processed are male for male sulphur
It is yellow) and refined honey.
The preparation method of the present invention is as follows：
(1) stock up：Wood of shiny-leaved yellowhorn root 500g, Fructus meliae toosendan 300g, myrobalan 100g, cape jasmine 100g, the male sulphur 100g of processing are selected, clearly
Crush and be put into clean pot after reason, add appropriate drinking water, medicinal material is covered, closing lid, when standing 12 is small；
(2) decoct：12 it is small when after, add the drinking water of 10 times of the mass fraction of medicinal material in step (1), be placed on warm fire
On decoct repeatedly 4 times, filtered through gauze, merging filtrate；
(3) concentrate：Filtrate is cooked by slow fire, 120 ° of the temperature of slow boiling, is constantly stirred, until being changed into dope, water evaporation
Fire is closed when complete, closing lid is stood, and it is cooled off naturally, forms clear cream；Clear cream is taken out and is smashed, and with 120 mesh of stainless steel pulverizer
Sieve crushed, formed medicinal powder；
(4) cream is received：Qinghuo reagent, adds refined honey, and the quality of refined honey and the mass ratio of clear cream are 1:1, and be stirred continuously and
The offscum on liquid level is plunderred, relative density is controlled in 1.2g/cm3。
(5) dispense：Soft extract fully let cool naturally after in aseptic subpackaged bag is fitted into, often packing band loading amount be 100g, fill
Measuring difference is《Chinese Pharmacopoeia version in 2015》Defined.
Embodiment 2
The invention mainly comprises following major ingredient：Wood of shiny-leaved yellowhorn root (the drying branch of Sapindaceae defoliation small arbor shiny-leaved yellowhorn or
Stem), Fructus meliae toosendan (dry mature fruit of melia toosendan section deciduous tree melia toosendan), myrobalan (gentleman section deciduous tree myrobalan or fine hair
Myrobalan), cape jasmine (dry fruit of Rubiaceae evergreen shrubs cape jasmine), (the sulfide-based mineral of monoclinic system processed are male for male sulphur
It is yellow) and refined honey.
The preparation method of the present invention is as follows：
(1) stock up：Wood of shiny-leaved yellowhorn root 1000g, Fructus meliae toosendan 600g, myrobalan 200g, cape jasmine 200g, the male sulphur 200g of processing are selected,
Crush and be put into clean pot after cleaning, add appropriate drinking water, medicinal material is covered, closing lid, when standing 12 is small；
(2) decoct：12 it is small when after, add the drinking water of 10 times of the mass fraction of medicinal material in step (1), be placed on warm fire
On decoct repeatedly 4 times, filtered through gauze, merging filtrate；
(3) filtrate is decocted：Filtrate is cooked by slow fire, 140 ° of the temperature of slow boiling, is constantly stirred, until being changed into dope, water
Fire is closed when being evaporated, closing lid is stood, and it is cooled off naturally, forms clear cream；Clear cream is taken out and is smashed, and with stainless steel pulverizer
The sieve of 120 mesh is crushed, and forms medicinal powder；
(4) cream is received：Qinghuo reagent, adds refined honey, and the quality of refined honey and the mass ratio of clear cream are 1.4:1, and be stirred continuously
With the offscum plunderred on liquid level, relative density is controlled in 1.3g/cm3。
(5) dispense：Soft extract fully let cool naturally after in aseptic subpackaged bag is fitted into, often packing band loading amount be 100g, fill
Measuring difference is《Chinese Pharmacopoeia version in 2015》Defined.
Embodiment 3
The invention mainly comprises following major ingredient：Wood of shiny-leaved yellowhorn root (the drying branch of Sapindaceae defoliation small arbor shiny-leaved yellowhorn or
Stem), Fructus meliae toosendan (dry mature fruit of melia toosendan section deciduous tree melia toosendan), myrobalan (gentleman section deciduous tree myrobalan or fine hair
Myrobalan), cape jasmine (dry fruit of Rubiaceae evergreen shrubs cape jasmine), (the sulfide-based mineral of monoclinic system processed are male for male sulphur
It is yellow) and refined honey.
The preparation method of the present invention is as follows：
(1) stock up：Wood of shiny-leaved yellowhorn root 2000g, Fructus meliae toosendan 1200g, myrobalan 400g, cape jasmine 400g, the male sulphur 400g of processing are selected,
Crush and be put into clean pot after cleaning, add appropriate drinking water, medicinal material is covered, closing lid, when standing 12 is small；
(2) concentrate：12 it is small when after, add the drinking water of 10 times of the mass fraction of medicinal material in step (1), be placed on warm fire
On decoct repeatedly 4 times, filtered through gauze, merging filtrate；
(3) filtrate is decocted：Filtrate is cooked by slow fire, 150 ° of the temperature of slow boiling, is constantly stirred, until being changed into dope, water
Fire is closed when being evaporated, closing lid is stood, and it is cooled off naturally, forms clear cream；
Clear cream is taken out and is smashed, and is crushed with the sieve of 120 mesh of stainless steel pulverizer, forms medicinal powder；
(4) cream is received：Qinghuo reagent, adds refined honey, and the quality of refined honey and the mass ratio of clear cream are 2.8:1, and be stirred continuously
With the offscum plunderred on liquid level, relative density is controlled in 1.4g/cm3。
(5) dispense：Soft extract fully let cool naturally after in aseptic subpackaged bag is fitted into, often packing band loading amount be 100g, fill
Measuring difference is《Chinese Pharmacopoeia version in 2015》Defined.
After three patients are using the soft extract of above-mentioned treatment grasserie, effect is as follows：
Experiment 1
The erythema that patient, Mr. Wang, male 48 years old, symptom Head And Face and whole skin shape size differ, around has the inflammatory red
Dizzy, the surface covering multilayer silvery white scales of skin that peel off, itch, removes the visible small blood point of the white scales of skin that peel off, itch after being treated 2 months with soft extract
Disappear, the silvery white scales of skin that peel off is reduced, and erythema reduces, the small erythema calmness pigment of area, according to the total mark meter of PASI scoring gained
Therapeutic index is calculated up to 52%.
Experiment 2
Patient, lattice, female 41 years old, symptom trunk and four limbs are dispersed in the erythema that shape size differs, and around have inflammatory blush,
Surface covers the thin layer silvery white scales of skin that peel off, and itch, removes the visible small blood point of the white scales of skin that peel off, scabies after being treated 2 months with soft extract
Itch disappearance, calm pigment after erythema and the silvery white scales of skin that peel off disappear, calculating therapeutic index according to the total mark of PASI scoring gained can
Up to 95.6%.
Experiment 3
Patient, it is neat certain, man 11 years old, the erythema that symptom body and the visible multiple shape sizes of four limbs differ, around there is inflammatory
Blush, surface cover a small amount of silvery white scales of skin that peel off, and itch, itch disappears after being treated 2 months with soft extract, and the silvery white scales of skin that peel off disappears,
Erythema reduces, and therapeutic index is calculated up to 68.6% according to the total mark of PASI scoring gained.
Claims (2)
- A kind of 1. soft extract for treating grasserie, it is characterised in that：Mainly include following major ingredient, (Sapindaceae falls wood of shiny-leaved yellowhorn root The drying branch or stem of leaf dungarunga shiny-leaved yellowhorn), Fructus meliae toosendan (dry mature fruit of melia toosendan section deciduous tree melia toosendan), myrobalan (gentleman section deciduous tree myrobalan or fine hair myrobalan), cape jasmine (dry fruit of Rubiaceae evergreen shrubs cape jasmine), male sulphur (have processed The sulfide-based mineral realgar of monoclinic system) and refined honey, major ingredient formed according to mass fraction：5-20 parts of wood of shiny-leaved yellowhorn root, Fructus meliae toosendan 3-12 parts, 1-4 parts of myrobalan, 1-4 parts of cape jasmine, 1-4 parts of male sulphur and refined honey, refined honey quality are 1 times -2.8 times of clear cream quality.
- A kind of 2. preparation method for the soft extract for treating grasserie, it is characterised in that：(1) stock up：Wood of shiny-leaved yellowhorn root, myrobalan are selected, Fructus meliae toosendan, cape jasmine, processes to crush after male sulphur cleaning and is put into clean pot, is added Enter appropriate drinking water, medicinal material is covered, closing lid, when standing 12 is small；(2) decoct：12 it is small when after, add the drinking water of 10 times of the mass fraction of medicinal material in step (1), be placed in warm fire anti- Decoct 4 times again, filtered through gauze, merging filtrate；(3) concentrate：Filtrate is cooked by slow fire, 120 ° -150 ° of the temperature range of slow boiling, is constantly stirred, until being changed into dope, water Fire is closed when being evaporated, closing lid is stood, and it is cooled off naturally, forms clear cream；Clear cream is taken out and is smashed, and with stainless steel pulverizer The sieve of 120 mesh is crushed, and forms medicinal powder；(4) cream is received：Qinghuo reagent, adds the refined honey of ormal weight, and is stirred continuously and plunders the offscum on liquid level, relative density control In 1.2g/cm3-1.4g/cm3；(5) dispense：Soft extract fully let cool naturally after in aseptic subpackaged bag is fitted into, often packing band loading amount be 100g, loading amount is poor It is different to be《Chinese Pharmacopoeia version in 2015》Defined.
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| CN201711400175.1A CN107929411A (en) | 2017-12-22 | 2017-12-22 | A kind of soft extract for treating grasserie and preparation method thereof |
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| CN201711400175.1A CN107929411A (en) | 2017-12-22 | 2017-12-22 | A kind of soft extract for treating grasserie and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110038061A (en) * | 2019-06-06 | 2019-07-23 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Sen Deng -4 ointment and preparation method thereof |
| CN110037986A (en) * | 2019-06-06 | 2019-07-23 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Sen Deng -4 nano-emulsion and preparation method thereof |
| CN110101763A (en) * | 2019-06-06 | 2019-08-09 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Sen Deng -4 creme and preparation method thereof |
| CN113521149A (en) * | 2021-06-29 | 2021-10-22 | 内蒙古民族大学附属医院 | New use of Senden-4 in aspect of liver protection |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1360904A (en) * | 2000-12-28 | 2002-07-31 | 计亚民 | Mongolian medicine ointment for treating psoriasis |
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2017
- 2017-12-22 CN CN201711400175.1A patent/CN107929411A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1360904A (en) * | 2000-12-28 | 2002-07-31 | 计亚民 | Mongolian medicine ointment for treating psoriasis |
Non-Patent Citations (2)
| Title |
|---|
| 夏应魁: "《皮肤病中医方剂制剂手册》", 29 February 2016, 陕西科学技术出版社 * |
| 龚千锋: "《中药炮制学 新世纪第4版》", 31 August 2016, 中国中医药出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110038061A (en) * | 2019-06-06 | 2019-07-23 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Sen Deng -4 ointment and preparation method thereof |
| CN110037986A (en) * | 2019-06-06 | 2019-07-23 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Sen Deng -4 nano-emulsion and preparation method thereof |
| CN110101763A (en) * | 2019-06-06 | 2019-08-09 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Sen Deng -4 creme and preparation method thereof |
| CN110037986B (en) * | 2019-06-06 | 2021-11-16 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Senden-4 nanoemulsion and preparation method thereof |
| CN113521149A (en) * | 2021-06-29 | 2021-10-22 | 内蒙古民族大学附属医院 | New use of Senden-4 in aspect of liver protection |
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Application publication date: 20180420 |