CN106491470A - A kind of Sanguis Draxonis extract cosmetics and preparation method thereof - Google Patents
A kind of Sanguis Draxonis extract cosmetics and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of Sanguis Draxonis extract cosmetics and preparation method thereof.The Sanguis Draxonis extract cosmetics include Sanguis Draxonis extract：The preparation method of the Sanguis Draxonis extract is as follows：Sanguis Draxonis are extracted using organic solvent, gained extracting solution is the Sanguis Draxonis extract；The organic solvent is polyhydric alcohol or white oil.In Sanguis Draxonis extract cosmetics of the present invention, Sanguis Draxonis extract is good with the cosmetic base compatibility, occurs without situations such as viscosity reduction, breakdown of emulsion；Sanguis Draxonis extract good stability used, for the mal-conditions such as high temperature, low temperature, illumination all very stable；Extraction ratio height (reaching more than 95%), Sanguis Draxonis significant loss are few, reached and Sanguis Draxonis raw material is maximally utilized.In addition, except antioxidation, anti-aging effects, also there is significant anti-acne and whitening function.
Description
Technical field
The present invention relates to a kind of Chinese medicine extract cosmetics and preparation method thereof, and in particular to a kind of Sanguis Draxonis extract
Cosmetic and preparation method thereof.
Background technology
At present, increasing Chinese medicinal plant composition is applied in skin care item, and medicine adornment has been already taken up more in the market
Carry out more important market position, the development and utilization of natural Chinese medicine plant component becomes the important development side of following cosmetic industry
To.This is significant for exploitation novel cosmetic, for the tcm development of China is using equally significant.
Sanguis Draxonis are liliaceous plant Dracaena cochinchinensiss Dranaena cochinchinensis (Lour.) S.C.Chen
The extracted resin for obtaining of resiniferous wood, mainly originates from the areas such as Guangxi and Yunnan.《Compendium of Materia Medica》Record its have warm in nature flat,
Sweet-salty, and the characteristic such as nontoxic, primary efficacy are blood circulation promoting and blood stasis dispelling, astringing to arrest bleeding etc..The chemical composition of Sanguis Draxonis is sufficiently complex,
Containing plurality of classes compounds such as flavonoid, simple phenols, steroidal, terpenoid, hydro carbons.
In the Sanguis Draxonis extract that different process conditions are obtained, the content of effective ingredient is different, and its drug effect purposes has difference
Not, be used for the use for preparing radioprotective agents as a kind of Sanguis Draxonis and Sanguis Draxonis extract are disclosed in 101559149 A of CN
On the way, the Sanguis Draxonis extract refers to Sanguis Draxonis total phenols and Sanguis Draxonis flavoniod；It is yellow that 1857570 A of CN disclose Chinese medicine Sanguis Draxonis
The process of preparing of ketone extract, the extract have stronger alpha-glucosaccharase enzyme inhibition activity and insulin secretion accelerating
Function, can play hypoglycemic effect.
During the research and development of cosmetics, Chinese medicine extract, as functional additive, is prepared with special work(
The important material base of effect cosmetics.But, carry as various Chinese herbal medicine additive necessary to these Cosmetic Manufacture are refined
Take that technology is perfect not enough, scientific and technological content is not high and effective ingredient lack modern science according to etc. reason so that domestic at present
Many Chinese medicine functional cosmetics using effects on the market are not obvious.The Sanguis Draxonis used for cosmetic that have/has reported are carried
The preparation technology for taking thing there is also and cosmetic base poor compatibility, and stability is poor, sensitization is high, extraction ratio is low or after need to concentrating
The problems such as cosmetics are made an addition to again.
Content of the invention
It is an object of the invention to provide a kind of Sanguis Draxonis extract cosmetics and preparation method thereof, the cosmetics are adopted
Sanguis Draxonis extract is little to human skin zest, and sensitization is low, good with the cosmetic base compatibility, good stability, and has
Antibacterial, anti-acne, antioxidation, defying age, whitening effect.
First purpose of the present invention is to provide a kind of Sanguis Draxonis extract cosmetics, and it includes Sanguis Draxonis extract；Institute
The preparation method for stating Sanguis Draxonis extract is as follows：Sanguis Draxonis are extracted using organic solvent, gained extracting solution is described
Sanguis Draxonis extract；The organic solvent is polyhydric alcohol or white oil.
In above-mentioned cosmetics, the Sanguis Draxonis can be Sanguis Draxonis crude drug；The particle diameter of the Sanguis Draxonis can be 10 mesh～
200 mesh, concretely 40～60 mesh, 60～100 mesh, 50～80 mesh, 40 mesh, 50 mesh, 60 mesh, 80 mesh or 100 mesh.
In above-mentioned cosmetics, used in the preferred cosmetics of the polyhydric alcohol, to the bland polyhydric alcohol of skin, such as
1-2- Propylene Glycol, 1,3- Propylene Glycol, 1,3 butylene glycol, glycerol etc..
In above-mentioned cosmetics, the white oil can be the white oil that the trade mark is 15# or 26#.The trade mark is moved according to 40 DEG C
The size of viscosity is dividing.
In above-mentioned cosmetics, the extraction can be Soakage extraction or reflux, extract,；The concrete steps of the Soakage extraction
As follows：In the Sanguis Draxonis, add the organic solvent to be soaked, after filtering, collect filtrate and the sanguis draconiss are obtained
Draconis extract.
In above-mentioned cosmetics, per Sanguis Draxonis described in 1g in add 1～1000g described in organic solvent be solid-liquid ratio can be 1：
(1～1000), concretely per Sanguis Draxonis described in 1g in add 20～500g, 20～200g, 20～100g, 20～50g, 50～
500g, 50～200g, 50～100g, 100～500g, 100～200g, 200～500g, 20g, 50g, 100g, 200g or 500g
The organic solvent, i.e. solid-liquid ratio concretely 1：(20～500), 1：(20～200), 1：(20～100), 1：(20～50),
1：(50～500), 1：(50～200), 1：(50～100), 1：(100～500), 1：(100～200), 1：(200～500), 1：
20、1：50、1：100、1：200 or 1：500.
In above-mentioned cosmetics, the temperature of the extraction is 25～180 DEG C, concretely 80～150 DEG C, 80～95 DEG C,
80～100 DEG C, 80～110 DEG C, 95～150 DEG C, 95～110 DEG C, 95～100 DEG C, 100～110 DEG C, 100～150 DEG C, 110～
150 DEG C, 80 DEG C, 95 DEG C, 100 DEG C, 110 DEG C or 150 DEG C, the time that extracts every time can be 10～1440 minutes, concretely 30
～120 minutes, 30～60 minutes, 30～90 minutes, 60～90 minutes, 60～120 minutes, 90～120 minutes, 30 minutes, 60
Minute, 90 minutes or 120 minutes.
In above-mentioned cosmetics, the number of times of the extraction can be 1～3 time, concretely 1～2 time, 2～3 times, 1 time, 2 times
Or 3 times.
In above-mentioned cosmetics, in the Sanguis Draxonis extract weight/mass percentage composition of Sanguis Draxonis total phenols be 0.01～
25%.
In above-mentioned cosmetics, the cosmetics also include base material of cosmetics；In the Sanguis Draxonis extract cosmetics, institute
The weight/mass percentage composition for stating Sanguis Draxonis extract can be 0.0001～10.0%, such as 1.0%.
The Sanguis Draxonis cosmetics can be multiple preparation shapes that can be accepted such as cream shape, gel or water preparation shape
Formula, including but not limited to：Facial film, facial cream, emulsion, essence or cosmetic water.
The cosmetics are cream shape, and by weight percentage, it can be grouped into by following groups：Sanguis Draxonis extract
0.0001～10.0%, deionized water 3～99.86%, glycerol 0.1～10%, trimethyl glycine (NMF-50) 0.001～
10%, hydroxyethyl cellulose (HEC) 0.0001～1%, Sorbitol 0.01～10%, D-panthenol 0.001～10%, monoglyceride
0.001～10%, white oil 0.001～10%, polydimethylsiloxane (DM100) 0.001～10%, cetostearyl alcohol (mixed alcohol)
0.001～10%, LGP 0.02～6%；
Specifically can be by following 1) -6) any one of group be grouped into：
1) Sanguis Draxonis extract 1.0～3.0%, deionized water 73～73.6%, glycerol 4.5～5.5%, trimethyl is sweet
Propylhomoserin (NMF-50) 4.0～5.0%, hydroxyethyl cellulose (HEC) 0.1～0.2%, Sorbitol 2.0%, D-panthenol 1.0% are single
Sweet ester 2.0%, white oil 7.0%, polydimethylsiloxane (DM100) 2.0%, cetostearyl alcohol (mixed alcohol) 1.0%, LGP
0.3%；
2) Sanguis Draxonis extract 1.0%, deionized water 73.6%, glycerol 5.0%, trimethyl glycine (NMF-50)
5.0%, hydroxyethyl cellulose (HEC) 0.1%, Sorbitol 2.0%, D-panthenol 1.0%, monoglyceride 2.0%, white oil 7.0% gather
Dimethyl siloxane (DM100) 2.0%, cetostearyl alcohol (mixed alcohol) 1.0%, LGP 0.3%；
3) Sanguis Draxonis extract 1.5%, deionized water 73%, glycerol 5.5%, trimethyl glycine (NMF-50)
4.5%, hydroxyethyl cellulose (HEC) 0.2%, Sorbitol 2.0%, D-panthenol 1.0%, monoglyceride 2.0%, white oil 7.0% gather
Dimethyl siloxane (DM100) 2.0%, cetostearyl alcohol (mixed alcohol) 1.0%, LGP 0.3%；
4) Sanguis Draxonis extract 2%, deionized water 73%, glycerol 5.5%, trimethyl glycine (NMF-50) 4.0%,
Hydroxyethyl cellulose (HEC) 0.2%, Sorbitol 2.0%, D-panthenol 1.0%, monoglyceride 2.0%, white oil 7.0%, poly dimethyl
Siloxanes (DM100) 2.0%, cetostearyl alcohol (mixed alcohol) 1.0%, LGP 0.3%；
5) Sanguis Draxonis extract 2.5%, deionized water 73%, glycerol 5.0%, trimethyl glycine (NMF-50)
4.0%, hydroxyethyl cellulose (HEC) 0.2%, Sorbitol 2.0%, D-panthenol 1.0%, monoglyceride 2.0%, white oil 7.0% gather
Dimethyl siloxane (DM100) 2.0%, cetostearyl alcohol (mixed alcohol) 1.0%, LGP 0.3%；
6) Sanguis Draxonis extract 3.0%, deionized water 73%, glycerol 4.5%, trimethyl glycine (NMF-50)
4.0%, hydroxyethyl cellulose (HEC) 0.2%, Sorbitol 2.0%, D-panthenol 1.0%, monoglyceride 2.0%, white oil 7.0% gather
Dimethyl siloxane (DM100) 2.0%, cetostearyl alcohol (mixed alcohol) 1.0%, LGP 0.3%.
The cosmetics are water preparation shape, and by weight percentage, it can be grouped into by following groups：Sanguis Draxonis extract
0.0001～10.0%, deionized water 23～99.86%, trimethyl glycine (NMF-50) 0.001～10%, Sorbitol 0.01
～20%, allantoin 0.001～10.0%, glycerol 0.1～20%, Xanthan gum original (HANSHENGJIAO) 0.1%, LGP 0.02～6%.
Specifically can be by following 1) -6) any one of group be grouped into：
1) Sanguis Draxonis extract 1.0～3.0%, deionized water 87～87.5%, trimethyl glycine (NMF-50) 4.5～
5.0%, Sorbitol 1.5～2.0%, allantoin 0.1%, glycerol 3.5～4.0%, Xanthan gum original (HANSHENGJIAO) 0.0001～
1%, LGP 0.3%；
2) Sanguis Draxonis extract 1.0%, deionized water 87.5%, trimethyl glycine (NMF-50) 5.0%, Sorbitol
2.0%, allantoin 0.1%, glycerol 4.0%, Xanthan gum original (HANSHENGJIAO) 0.1%, LGP 0.3%；
3) Sanguis Draxonis extract 1.5%, deionized water 87%, trimethyl glycine (NMF-50) 5.0%, Sorbitol
2.0%, allantoin 0.1%, glycerol 4.0%, Xanthan gum original (HANSHENGJIAO) 0.1%, LGP 0.3%；
4) Sanguis Draxonis extract 2%, deionized water 87%, trimethyl glycine (NMF-50) 4.5%, Sorbitol 2.0%,
Allantoin 0.1%, glycerol 4.0%, Xanthan gum original (HANSHENGJIAO) 0.1%, LGP 0.3%；
5) Sanguis Draxonis extract 2.5%, deionized water 87%, trimethyl glycine (NMF-50) 4.5%, Sorbitol
2.0%, allantoin 0.1%, glycerol 3.5%, Xanthan gum original (HANSHENGJIAO) 0.1%, LGP 0.3%；
6) Sanguis Draxonis extract 3%, deionized water 87%, trimethyl glycine (NMF-50) 4.5%, Sorbitol 1.5%,
Allantoin 0.1%, glycerol 3.5%, Xanthan gum original (HANSHENGJIAO) 0.1%, LGP 0.3%.
The cosmetics are gel, and by weight percentage, it can be grouped into by following groups：Sanguis Draxonis extract
0.0001～10.0%, deionized water 32～99.96%, Sorbitol 0.01～10%, glycerol 0.1～20%, butanediol
0.01～20%, Kappa mother U20 (CARBOMER U20) 0.0001～1%, Methylisothiazolinone (MTI) 0.02～6%, hydrogen
Sodium oxide (NAON) 0.0001～1.0%.
Specifically can be by following 1) -6) any one of group be grouped into：
1) Sanguis Draxonis extract 1.0～3.0%, deionized water 88～88.5%, Sorbitol 2%, glycerol 3.3～
4.0%, 1,3 butylene glycol 0.01～20%, Kappa mother U20 (CARBOMER U20) 0.0001～1%, Methylisothiazolinone
(MTI) 3.0～4.0%, sodium hydroxide (NAON) 0.05～0.2%；
2) Sanguis Draxonis extract 1.0%, deionized water 88.5%, Sorbitol 2%, glycerol 4.0%, 1,3 butylene glycol
4.0%, Kappa U20 (CARBOMER U20) 0.3%, Methylisothiazolinone (MTI) 0.15%, sodium hydroxide (NAON)
0.05%；
3) Sanguis Draxonis extract 1.5%, deionized water 88.2%, Sorbitol 2%, glycerol 3.7%, 1,3 butylene glycol
4.0%, Kappa U20 (CARBOMER U20) 0.3%, Methylisothiazolinone (MTI) 0.2%, sodium hydroxide (NAON)
0.1%；
4) Sanguis Draxonis extract 2%, deionized water 88.2%, Sorbitol 2%, glycerol 3.7%, 1,3 butylene glycol
3.5%, Kappa U20 (CARBOMER U20) 0.3%, Methylisothiazolinone (MTI) 0.2%, sodium hydroxide (NAON)
0.1%；
5) Sanguis Draxonis extract 2.5%, deionized water 88%, Sorbitol 2%, glycerol 3.5%, 1,3 butylene glycol
3.3%, Kappa U20 (CARBOMER U20) 0.3%, Methylisothiazolinone (MTI) 0.2%, sodium hydroxide (NAON)
0.2%；
6) Sanguis Draxonis extract 3%, deionized water 88%, Sorbitol 2%, glycerol 3.3%, 1,3 butylene glycol 3.0%,
Kappa U20 (CARBOMER U20) 0.3%, Methylisothiazolinone (MTI) 0.2%, sodium hydroxide (NAON) 0.2%.
It is a further object to provide a kind of preparation method of above-mentioned Sanguis Draxonis extract cosmetics, it include as
Lower step：The Sanguis Draxonis extract and base material of cosmetics are mixed, you can obtain the Sanguis Draxonis cosmetics.
Final object of the present invention is to provide above-mentioned Sanguis Draxonis extract cosmetics as with following 1) -8) in
At least one function cosmetics in application：
1) acne pathogenic bacterium are suppressed；
2) anti-acne；
3) DPPH free radicals are removed；
4) ABTS free radicals are removed；
5) antioxidation；
6) defying age；
7) suppress the activity of tryrosinase；
8) whitening.
The present invention has the advantages that：
Instant invention overcomes using organic solvent (non-cosmetics such as ethanol, methanol, acetone, ethyl acetate in prior art
Common solvent) Sanguis Draxonis are extracted, extract extraction ratio is not high or made an addition in cosmetics again after need to concentrating, with cosmetic base phase
Capacitive is poor, the problems such as stability is poor, sensitization is high.
In Sanguis Draxonis extract cosmetics of the present invention, Sanguis Draxonis extract is good with the cosmetic base compatibility, without viscosity reduction,
Situations such as breakdown of emulsion, occurs；Sanguis Draxonis extract good stability used, for the mal-conditions such as high temperature, low temperature, illumination all very stable；
Extraction ratio height (reaching more than 95%), Sanguis Draxonis significant loss are few, reached and Sanguis Draxonis raw material is maximally utilized.In addition,
Except antioxidation, anti-aging effects, also there is significant anti-acne and whitening function.
Specific embodiment
Experimental technique used in following embodiments if no special instructions, is conventional method.
In following embodiments, material used, reagent etc., if no special instructions, commercially obtain.
Kappa U20 (20 polymer of Carbopol Ultrez), INCI titles：Acrylates/C10-30 Alkyl
Acrylate Crosspolymer.
MTI is the product purchased from Guangdong Zhong Peng Chemical Co., Ltd.s, and name of product is MTI cosmetics preservatives, its activity
Group is divided into Methylisothiazolinone, iodine propinyl butyl first ammonium acid fat.
NMF-50, chemical name are trimethyl glycine.
HEC (Hydroxyethyl Cellulose), chemical name are hydroxyethyl cellulose, and specification is hydroxyethyl cellulose
HHR250.
DM100, chemical name are polydimethylsiloxane.
Mixed alcohol, chemical name are cetostearyl alcohol.
LGP is the product purchased from Guangdong Zhong Peng Chemical Co., Ltd.s, and name of product is LGP cosmetics preservatives, activity into
It is divided into DMDM Hydantoin, Methylisothiazolinone (MIT), iodine propilolic alcohol butyl mephenesin Carbamate (IPBC)
Transparent HANSHENGJIAO, chemical name are xanthan gum.
In following embodiments, in Sanguis Draxonis extract, the assay method of total phenol content is as follows：
A. prepared by reference substance solution
Precision weighing lourerin B standard substance 8.82mg, is placed in 100mL volumetric flasks, plus dehydrated alcohol constant volume, shakes up, i.e.,
Obtain solution of the lourerin B content for 0.0882mg/ml.
B. Specification Curve of Increasing
Lourerin B reference substance (0.0882mg/ml) 0.5,0.6,0.75,1.0,1.3,1.5ml is taken, 10ml appearances are respectively placed in
In measuring bottle, plus dehydrated alcohol constant volume, shake up.Blank is done with dehydrated alcohol, mensuration absorbance under selected wavelength 280nm.To inhale
Receipts degree is abscissa, and reference substance concentration C (mg/mL) is vertical coordinate, draws standard curve.
C. total phenol content is determined
Precision takes sample and is configured to suitable concentration solution, determines trap, according to the mark that sets up under selected wavelength 280nm
Directrix curve carries out the calculating of total phenol content.
After in following embodiments, Sanguis Draxonis extracting solution yield is according to Sanguis Draxonis extracting solution total phenol content, inventory and extraction
Extracting solution total amount is calculated.Computing formula is as follows：
In formula (1), the implication and unit that each physical quantity is represented is as follows：
C：Extracting solution total phenol content, mg/mL
V：Extracting solution cumulative volume, mL
M：Make the quality of total phenols in the Sanguis Draxonis active compound that extracting solution is used, g.
The preparation of embodiment 1, Sanguis Draxonis extract
First, Sanguis Draxonis extract
Test 1, prepare Sanguis Draxonis extract
Sanguis Draxonis are crushed to 60 mesh, according to 1：50 ratio (mass ratio) adds 1,2-PD, soaks 1 at 95 DEG C
Hour, to extract after completing, filtered with filter board, gained filtrate is Sanguis Draxonis extract.
In this experiment, solid-liquid ratio is 1：50, Extracting temperature is 95 DEG C, and the time is 1 hour, and extraction time is 1 time.Gained is carried
It is 0.91% to take liquid total phenol content, and extraction ratio is 95%.
Test 2, prepare Sanguis Draxonis extract
Sanguis Draxonis are crushed to 100 mesh, according to 1：20 ratio (mass ratio) adds 1,3-PD, soaks at 80 DEG C
1.5 hours, after the completion of extraction, filtered with filter board, collect filtrate, the filtering residue for obtaining is repeated last time operation, merged all
Filtrate is Sanguis Draxonis extract.
In this experiment, solid-liquid ratio is 1：20, Extracting temperature is 80 DEG C, and the time is 1.5 hours, and extraction time is 2 times.Gained
Extracting solution total phenol content is 1.2%, and extraction ratio is 96%.
Test 3, prepare Sanguis Draxonis extract
Sanguis Draxonis are crushed to 40 mesh, according to 1：100 ratio (mass ratio) adds 1,3 butylene glycol, soaks at 100 DEG C
Bubble 0.5 hour, extracts after completing, is filtered with filter board, and gained filtrate is Sanguis Draxonis extract.
In this experiment, solid-liquid ratio is 1：100, Extracting temperature is 100 DEG C, and the time is 0.5 hour, and extraction time is 1 time.Institute
It is 0.32% to obtain extracting solution total phenol content, and extraction ratio is 92%.
Test 4, prepare Sanguis Draxonis extract
Sanguis Draxonis are crushed to 80 mesh, according to 1：200 ratio (mass ratio) adds glycerol, soaks 1.5 at 110 DEG C
Hour, after the completion of extraction, filtered with filter board, collect filtrate；The filtering residue for obtaining is repeated aforesaid operations, merging filtrate is
Sanguis Draxonis extract.
In this experiment, solid-liquid ratio is 1：200, Extracting temperature is 110 DEG C, and the time is 1.5 hours, and extraction time is 2 times.Institute
It is 0.10% to obtain extracting solution total phenol content, and extraction ratio is 90%.
Test 5, prepare Sanguis Draxonis extract
Sanguis Draxonis are crushed to 50 mesh, according to 1：500 ratio (mass ratio) adds 15# white oils, soaks 2 at 150 DEG C
Hour, extract after completing, filtered with filter board, collect filtrate；The filtering residue for obtaining is repeated aforesaid operations, gained filtering residue is again
Secondary repetition aforesaid operations, merge all filtrates and are Sanguis Draxonis extract.
In this experiment, solid-liquid ratio is 1：500, Extracting temperature is 150 DEG C, and the time is 2 hours, and extraction time is 3 times.Gained
Extracting solution total phenol content is 0.03%, and extraction ratio is 85%.
2nd, the effect experimental of Sanguis Draxonis extract
(1) Sanguis Draxonis extract stability test
Treating excess syndrome tests in 1 obtained Sanguis Draxonis extract 100g respectively loaded on being placed in varying environment in four transparent sample bottles
Under, four bottles of samples are periodically taken while observation state.Four bottles of samples are respectively placed in indoor sunlight irradiation position, in 38 degree of incubators ,-
20 degree of freezer compartment of refrigerator, room temperature shady place, Yu Yizhou, two weeks, it is minimum that one month observes its state change respectively, shows dragon
Sanguis Draxonis extract has good stability.
Treating excess syndrome tests the Sanguis Draxonis extract 100g made in 2 respectively loaded on being placed in varying environment in four transparent sample bottles
Under, four bottles of samples are periodically taken while observation state.Four bottles of samples are respectively placed in indoor sunlight irradiation position, in 38 degree of incubators ,-
20 degree of freezer compartment of refrigerator, room temperature shady place, Yu Yizhou, two weeks, it is minimum that one month observes its state change respectively, shows dragon
Sanguis Draxonis extract has good stability.
Treating excess syndrome tests the Sanguis Draxonis extract 100g made in 3 respectively loaded on being placed in varying environment in four transparent sample bottles
Under, four bottles of samples are periodically taken while observation state.Four bottles of samples are respectively placed in indoor sunlight irradiation position, in 38 degree of incubators ,-
20 degree of freezer compartment of refrigerator, room temperature shady place, Yu Yizhou, two weeks, it is minimum that one month observes its state change respectively, shows dragon
Sanguis Draxonis extract has good stability.
Treating excess syndrome tests the Sanguis Draxonis extract 100g made in 4 respectively loaded on being placed in varying environment in four transparent sample bottles
Under, four bottles of samples are periodically taken while observation state.Four bottles of samples are respectively placed in indoor sunlight irradiation position, in 38 degree of incubators ,-
20 degree of freezer compartment of refrigerator, room temperature shady place, Yu Yizhou, two weeks, it is minimum that one month observes its state change respectively, shows dragon
Sanguis Draxonis extract has good stability.
Treating excess syndrome tests the Sanguis Draxonis extract 100g made in 5 respectively loaded on being placed in varying environment in four transparent sample bottles
Under, four bottles of samples are periodically taken while observation state.Four bottles of samples are respectively placed in indoor sunlight irradiation position, in 38 degree of incubators ,-
20 degree of freezer compartment of refrigerator, room temperature shady place, Yu Yizhou, two weeks, it is minimum that one month observes its state change respectively, shows dragon
Sanguis Draxonis extract has good stability.
(2) extracorporeal bacteria inhibitor test of Sanguis Draxonis extract
Acne pathogenic bacterium, propionibacterium acness and staphylococcus aureuses are selected as test strain.Propionibacterium acness
The ATCC numberings of Propionibacterium acnes are 10312, and the public can be commercially available from ATCC.Staphylococcus aureuses
The ATCC numberings of Staphylococcus aureus are 10384, and the public can be commercially available from ATCC.
Configuration contains bacterium about 1 × 106The bacteria suspension of CFU/mL.Filter paper is cut into diameter 6mm disks and xeothermic is gone out through 160 DEG C
Filter paper is put into antibacterial stock solution (experiment 1- tests 5 preparation-obtained Sanguis Draxonis extracts) with aseptic nipper by bacterium 2h respectively
Take out after middle immersion 1h.Take 0.2mL bacteria suspensions respectively to have been solidified in culture medium in correspondingly aseptic, uniform with sterile glass triangle bamboo rake
It is flat board containing bacterium to be coated, and soaked filter paper is placed in plate central authorities, and makees blank, carry out three groups of parallel examinations
Test, be put in anaerobism or biochemical cultivation case 37 DEG C and cultivate 24 hours.
Observation inhibition zone is taken out, as a result as shown in table 1.The appearance of inhibition zone proves Sanguis Draxonis extract respectively to acne third
Acidfast bacilli and staphylococcus aureuses have certain inhibitory action, and antibacterial circle diameter is bigger, and bacteriostatic activity is stronger.
Table 1, Sanguis Draxonis extracting solution inhibition zone data table
Note：" ＜ 6 " represents do not have inhibition zone.
(3) the anti-oxidation efficacy evaluation of Sanguis Draxonis extract
1) DPPH radical scavenging activities are determined
DPPH is a kind of organic free radical of early stage synthesis, is commonly used to the hydrogen supply capacity for assessing polyphenoils, and it is organic
Highly stable in solvent, in purple, and there are a characteristic absorption peak, when free radical scavenger is run into, DPPH at 517nm
Lone pair electrons be paired and make which fade, that is, diminish in the light absorption value of maximum absorption wave strong point.Therefore, can pass through to determine
The change of light absorption value is evaluating elimination effect of the sample to DPPH free radicals.
Prepare liquid：The Sanguis Draxonis stock solution prepared in experiment 1- experiments 5 is prepared with sterilized water respectively former containing 0.30%
The diluent of liquid.Using sterilized water as blank, 15 μ g/mL vitamin c solutions as control.
The prepare liquid and 5.8mL DPPH solution for taking 0.1mL is mixed as A；Take the dehydrated alcohol and 5.8mL DPPH of 0.2mL
It is B that solution is mixed；The prepare liquid of the dehydrated alcohol and 0.2mL that take 5.8mL is mixed as C；After reaction 30min, under 517nm respectively
Determine the absorbance of A, B, C.
Computational methods：
The 0.3% Sanguis Draxonis extracting solution and control that the Sanguis Draxonis extract dilution that different embodiments are prepared is obtained is right
DPPH free radical scavenging activities are as shown in table 2.
Table 2, Sanguis Draxonis extracting solution DPPH free radical scavenging activities
2) ABTS radical scavenging activities are determined
ABTS be oxidized under appropriate oxidant effect the ABTS of green+, in the presence of polyphenoils ABTS+
Producing and being suppressed, the absorbance for ABTS being determined in 734nm can determine and calculate the total antioxidant capacity of sample.
500 μ L prepare liquids are sequentially added to A group test tubes, by 500 μ L ethanol waters add B group test tubes, add reagent and
When block, be vortexed mix.500 μ L ABTS free radical stock solutions are sequentially added in A test tubes and B test tubes, reagent is added timely
Block, is vortexed and mixes.Light absorption value is detected in 734nm after reaction 10min.500 μ L prepare liquids and 500 μ are sequentially added to C group test tubes
L ethanol waters are vortexed and mix, and survey light absorption value at 734nm.
Computational methods：
Prepare liquid：The Sanguis Draxonis stock solution that experiment 1- experiments 5 are prepared is formulated as 0.10% respectively using sterilized water
Dilution factor.Using sterilized water as blank.Using 0.001% vitamin c solution as control.
The Sanguis Draxonis extract that different embodiments are prepared dilutes obtain 0.10% Sanguis Draxonis extracting solution and control
As shown in table 3 to ABTS free radical scavenging activities.
Table 3, Sanguis Draxonis extracting solution ABTS free radical scavenging activities
By above experimental data, Sanguis Draxonis extract has stronger oxidation resistance, can remove free radical, promotees
Enter cellular metabolism, strengthen cell viability, improve the 26S Proteasome Structure and Function of body, improve body vitality, so as to delay cell senescence,
Play the effect of its defying age.
(5) whitening function of Sanguis Draxonis extract
Tryrosinase belongs to oxidoreductase, is the major rate-limiting enzyme of B16 cell, and its active size determines melanin shape
Into quantity, many whitenings that sells in the market, speckle dispelling product be all to suppress tyrosinase activity to reach whitening function,
Therefore be to evaluate the leading indicator of whitening cosmetic to the power of tyrosinase inhibitory action.
L-Tyrosine generates DOPA in the presence of tryrosinase, and DOPA is further acted on generation DOPA by tryrosinase
Quinone, eventually passes a series of biochemical processes and generates melanin.Wherein DOPA quinone has maximum absorption band at 475nm wavelength, passes through
In unit interval, its absorbance is determined, the vigor size of indirect reaction enzyme, through being calculated the suppression ratio of tryrosinase.
Experiment is divided into four groups, in each group accurately adds phosphate buffer, L-Tyrosine enzyme molten according to amounts of components in table 4
Liquid and prepare liquid, mix, and are incubated 10min in 37 DEG C.Phosphate buffer：Weigh 71.63gNa2HPO4·12H2O, uses deionization
Fully dissolving constant volume is configured to 0.2mol/LNa in 1000mL volumetric flasks2HPO4Solution；Weigh 31.20g NaH2PO4·
2H2O, deionized water fully dissolve constant volume in 1000mL volumetric flasks, are configured to 0.2mol/LNaH2PO4Solution；Both according to
1:1 ratio mixes, and is configured to the phosphate buffer that pH value is 6.8.Tyrosinase solution：It is 200U/ according to enzyme activity unit
ML weighs a certain amount of tryrosinase, is dissolved with phosphate buffer, and constant volume is stored in refrigerator in volume required volumetric flask
Standby.Wherein, temperature be 25 DEG C, pH is 6.5, wavelength be 280nm when, per minute cause absorbance decline 0.001 be one
Unit of activity (U).
In A groups and C groups, add tyrosinase solution to mix, react 10min, reaction goes out to survey in 475nm after terminating immediately
Fixed four groups of absorbances.
Table 4, test fluid amounts of components table
Computational methods：
Prepare liquid：The Sanguis Draxonis extract stock solution that experiment 1- experiments 5 are prepared is prepared containing 1.0% with sterilized water respectively
The diluent of stock solution.Using sterilized water as blank.Using 0.1% arbutin solution as control.
1.0% Sanguis Draxonis extracting solution and compare to cheese that the Sanguis Draxonis extract dilution that different embodiments are prepared is obtained
The suppression ratio of propylhomoserin enzyme is as shown in table 5.
Table 5, Sanguis Draxonis extracting solution tyrosinase inhibition rate
By the above results as can be seen that in the suitable interpolation concentration range of cosmetics, Sanguis Draxonis extracting solution presents very
Good tryrosinase rejection ability, Sanguis Draxonis extracting solution is a outstanding natural plant whitening composition.
(6) safety evaluatio of Sanguis Draxonis extract
1) toxicology detection (irritation test)
This experiment is (former by the Sanguis Draxonis extract prepared in experiment 1- experiments 5 respectively using 5% Sanguis Draxonis extracting solution
Liquid is obtained using sterilized water dilution) as test article, according to《Cosmetics health specification》2007 editions requirements carry out skin irritation
Test, experimental result are shown in Table shown in 6-10.
Table 6, irritation test data (experiment 1)
Table 7, irritation test data (experiment 2)
Table 8, irritation test data (experiment 3)
Table 9, irritation test data (experiment 4)
Table 10, irritation test data (experiment 5)
Experimental data shows that 5% Sanguis Draxonis extracting solution has no irritative response, passes through irritation test, symbol
Close and require.
2) human safety detection (human skin patch)
This experiment (is extracted by the Sanguis Draxonis prepared in experiment 1- experiments 5 respectively using 5% concentration Sanguis Draxonis extracting solution
Thing stock solution is obtained using sterilized water dilution) as test article, according to《Cosmetics health specification》2007 editions requirements carry out skin envelope
Closing property patch test, participates in experiment number for 30 people, and test data is shown in Table shown in 11-15.
Table 11, human skin patch data (experiment 1)
Table 12, human skin patch data (experiment 2)
Table 13, human skin patch data (experiment 3)
Table 14, human skin patch data (experiment 4)
Table 15, human skin patch data (experiment 5)
Experimental data shows that 5% Sanguis Draxonis extracting solution passes through human body skin patch reality without human body skin adverse reaction
Test, meet the requirements.
Therefore, detected by toxicology detection and human safety, it was demonstrated that Sanguis Draxonis extracting solution is in the range of debita spissitudo
Using not stimulating to human body and any untoward reaction, it is safe and reliable that Sanguis Draxonis extracting solution is added into used in cosmetics
's.
Embodiment 2, the preparation (water preparation shape) of Sanguis Draxonis extract cosmetics
First, formula
Formula 1：Sanguis Draxonis extract (experiment 1) 1.0%, deionized water 87.5%, NMF-50 5.0%, Sorbitol
2.0%, allantoin 0.1%, glycerol 4.0%, transparent HANSHENGJIAO 0.1%, LGP 0.3%.
Formula 2：Sanguis Draxonis extract (experiment 2) 1.5%, deionized water 87%, NMF-50 5.0%, Sorbitol 2.0%,
Allantoin 0.1%, glycerol 4.0%, transparent HANSHENGJIAO 0.1%, LGP 0.3%.
Formula 3：Sanguis Draxonis extract (experiment 3) 2%, deionized water 87%, NMF-50 4.5%, Sorbitol 2.0%, urine
Bursin 0.1%, glycerol 4.0%, transparent HANSHENGJIAO 0.1%, LGP 0.3%.
Formula 4：Sanguis Draxonis extract (experiment 4) 2.5%, deionized water 87%, NMF-50 4.5%, Sorbitol 2.0%,
Allantoin 0.1%, glycerol 3.5%, transparent HANSHENGJIAO 0.1%, LGP 0.3%.
Formula 5：Sanguis Draxonis extract (experiment 5) 3%, deionized water 87%, NMF-50 4.5%, Sorbitol 1.5%, urine
Bursin 0.1%, glycerol 3.5%, transparent HANSHENGJIAO 0.1%, LGP 0.3%.
2nd, preparation method
Table 16, the composition of raw materials of water preparation shape Sanguis Draxonis extract cosmetics
As shown in table 16, A phase all the components are weighed in proportion, mixes, after being stirred and heated to 95 DEG C of insulation 30min, drop
Temperature stirs to 60 DEG C of interpolation B phases, fill.
Embodiment 3, the preparation (gel) of Sanguis Draxonis extract cosmetics
First, formula
Formula 1：Sanguis Draxonis extract (experiment 1) 1.0%, deionized water 88.5%, Sorbitol 2%, glycerol 4.0%,
1,3 butylene glycol 4.0%, Kappa U20 0.3%, MTI0.15%, NAON 0.05%.
Formula 2：Sanguis Draxonis extract (experiment 2) 1.5%, deionized water 88.2%, Sorbitol 2%, glycerol 3.7%,
1,3 butylene glycol 4.0%, Kappa U20 0.3%, MTI0.2%, NAON 0.1%.
Formula 3：Sanguis Draxonis extract (experiment 3) 2%, deionized water 88.2%, Sorbitol 2%, glycerol 3.7%, 1,
3- butanediols 3.5%, Kappa U20 0.3%, MTI0.2%, NAON 0.1%.
Formula 4：Sanguis Draxonis extract (experiment 4) 2.5%, deionized water 88%, Sorbitol 2%, glycerol 3.5%, 1,
3- butanediols 3.3%, Kappa U20 0.3%, MTI0.2%, NAON 0.2%.
Formula 5：Sanguis Draxonis extract (experiment 5) 3%, deionized water 88%, Sorbitol 2%, glycerol 3.3%, 1,3-
Butanediol 3.0%, Kappa U20 0.3%, MTI0.2%, NAON 0.2%.
2nd, preparation method
Table 17, the composition of raw materials of gel Sanguis Draxonis extract cosmetics
As shown in table 17, A phase all the components are weighed in proportion, mixes, after being stirred and heated to 95 DEG C of insulation 30min, drop
Temperature is added C phases after stirring, is stirred to 60 DEG C of interpolation B phases, evacuation, fill.
Embodiment 4, the preparation (cream) of Sanguis Draxonis extract cosmetics
First, formula
Formula 1：Sanguis Draxonis extract (experiment 1) 1.0%, deionized water 73.6%, glycerol 5.0%, NMF-50
5.0%, HEC 0.1%, Sorbitol 2.0%, D-panthenol 1.0%, monoglyceride 2.0%, white oil 7.0%, DM100 2.0% are mixed
Alcohol 1.0%, LGP 0.3%.
Formula 2：Sanguis Draxonis extract (experiment 2) 1.5%, deionized water 73%, glycerol 5.5%, NMF-50 4.5%,
HEC 0.2%, Sorbitol 2.0%, D-panthenol 1.0%, monoglyceride 2.0%, white oil 7.0%, DM100 2.0% mix alcohol
1.0%, LGP 0.3%.
Formula 3：Sanguis Draxonis extract (experiment 3) 2%, deionized water 73%, glycerol 5.5%, NMF-50 4.0%,
HEC 0.2%, Sorbitol 2.0%, D-panthenol 1.0%, monoglyceride 2.0%, white oil 7.0%, DM100 2.0% mix alcohol
1.0%, LGP 0.3%.
Formula 4：Sanguis Draxonis extract (experiment 4) 2.5%, deionized water 73%, glycerol 5.0%, NMF-50 4.0%,
HEC 0.2%, Sorbitol 2.0%, D-panthenol 1.0%, monoglyceride 2.0%, white oil 7.0%, DM100 2.0% mix alcohol
1.0%, LGP 0.3%.
Formula 5：Sanguis Draxonis extract (experiment 5) 3.0%, deionized water 73%, glycerol 4.5%, NMF-50 4.0%,
HEC 0.2%, Sorbitol 2.0%, D-panthenol 1.0%, monoglyceride 2.0%, white oil 7.0%, DM100 2.0% mix alcohol
1.0%, LGP 0.3%.
2nd, preparation method
Table 18, the composition of raw materials of cream shape Sanguis Draxonis extract cosmetics
As shown in table 18, by A phases, all the components are weighed by B phases respectively in proportion, mixing, are stirred and heated to 95 DEG C of insulations
After 30min, stirring after homogenizing 30min cools to 60 DEG C of interpolation C phases, stirs, evacuation, fill.
Embodiment 5, clinical trial
(1) cosmetics obtained in above-described embodiment, choose 18-25 year volunteer 192, are randomly divided into 16 groups, per group 12
People, continuous (per per capita only using corresponding embodiment or comparative example cosmetics, not using other product for resolving poxes) on probation 30 days,
The anti-acne effect of obtained cosmetics in the various embodiments described above is evaluated in relative analyses, the results are shown in Table 19.
Test zone：At face head's pox.
Evaluation criterion：Effective, effectively, invalid.Wherein comedo substantially eliminate be judged as effective；Part comedo is eliminated to be sentenced
Break as effective；Comedo do not reduce or reduce substantially then be not judged as invalid.
Comparative example 1：Certain brand acne-eliminating cosmetic commercially available.
The anti-acne effect of obtained Sanguis Draxonis extract cosmetics in table 19, each embodiment
| Group | Effectively | Effective | Invalid |
| Embodiment 2 (formula 1) | 3 | 8 | 1 |
| Embodiment 2 (formula 2) | 3 | 9 | 0 |
| Embodiment 2 (formula 3) | 3 | 8 | 1 |
| Embodiment 2 (formula 4) | 3 | 6 | 3 |
| Embodiment 2 (formula 5) | 3 | 5 | 4 |
| Embodiment 3 (formula 1) | 6 | 6 | 0 |
| Embodiment 3 (formula 2) | 5 | 5 | 2 |
| Embodiment 3 (formula 3) | 5 | 5 | 2 |
| Embodiment 3 (formula 4) | 5 | 4 | 3 |
| Embodiment 3 (formula 5) | 4 | 4 | 4 |
| Embodiment 4 (formula 1) | 4 | 7 | 1 |
| Embodiment 4 (formula 2) | 4 | 7 | 1 |
| Embodiment 4 (formula 3) | 4 | 6 | 2 |
| Embodiment 4 (formula 4) | 4 | 6 | 2 |
| Embodiment 4 (formula 5) | 3 | 5 | 4 |
| Comparative example 1 | 2 | 4 | 6 |
(2) cosmetics obtained in above-described embodiment, choose 160 personnel of 25-55 year, are randomly divided into 16 groups, per group 10
People, continuous trying out 30 days (per per capita only using corresponding embodiment or comparative example cosmetics, do not use other whitening antioxidations
Product), the whitening of obtained cosmetics in the various embodiments described above and antioxidant effect are evaluated in relative analyses.Wherein, described
Whitening and the improvement situation that antioxidant effect is secretly old skin, mottle, pachylosiies etc., the results are shown in Table 20.
Test zone：Facial skin.
Evaluation criterion：Experienced by patient's readme, and computer compares skin texture illustrated handbook and determines skin improvement degree.Effectively：
The colour of skin is highlighted, mottle color dodge, and skin sophistication is improved.Invalid：Skin complexion, mottle and sophistication are front with test without any
Change.
Comparative example 2：Certain brand whitening antioxidation cosmetic product commercially available.
The whitening of obtained Sanguis Draxonis extract cosmetics and antioxidant effect in table 20, each embodiment
| Group | Effectively | Invalid |
| Embodiment 2 (formula 1) | 10 | 0 |
| Embodiment 2 (formula 2) | 9 | 1 |
| Embodiment 2 (formula 3) | 9 | 1 |
| Embodiment 2 (formula 4) | 8 | 2 |
| Embodiment 2 (formula 5) | 7 | 3 |
| Embodiment 3 (formula 1) | 10 | 0 |
| Embodiment 3 (formula 2) | 9 | 1 |
| Embodiment 3 (formula 3) | 9 | 1 |
| Embodiment 3 (formula 4) | 9 | 1 |
| Embodiment 3 (formula 5) | 8 | 2 |
| Embodiment 4 (formula 1) | 10 | 0 |
| Embodiment 4 (formula 2) | 10 | 0 |
| Embodiment 4 (formula 3) | 9 | 1 |
| Embodiment 4 (formula 4) | 8 | 2 |
| Embodiment 4 (formula 5) | 7 | 3 |
| Comparative example 2 | 4 | 6 |
Claims (8)
1. a kind of Sanguis Draxonis extract cosmetics, it is characterised in that：It includes Sanguis Draxonis extract：The Sanguis Draxonis extract
Preparation method is as follows：Sanguis Draxonis are extracted using organic solvent, gained extracting solution is the Sanguis Draxonis extract；Described
Organic solvent is polyhydric alcohol or white oil.
2. cosmetics according to claim 1, it is characterised in that：The polyhydric alcohol be 1-2- Propylene Glycol, 1,3- Propylene Glycol,
Any one in 1,3 butylene glycol and glycerol.
3. cosmetics according to claim 1 and 2, it is characterised in that：The white oil is the white oil that the trade mark is 15# or 26#.
4. cosmetics according to any one of claim 1-3, it is characterised in that：Described it is extracted as Soakage extraction or backflow
Extract.
5. cosmetics according to any one of claim 1-4, it is characterised in that：Add 1 in per Sanguis Draxonis described in 1g～
Organic solvent described in 1000g；And/or,
The temperature of the extraction is 25～180 DEG C, and the time that extracts every time is 10～1440 minutes；And/or,
The number of times of the extraction is 1～3 time.
6. cosmetics according to any one of claim 1-5, it is characterised in that：The cosmetics are carried by the Sanguis Draxonis
Take thing and base material of cosmetics composition；In the Sanguis Draxonis extract cosmetics, the weight/mass percentage composition of the Sanguis Draxonis extract
For 0.0001～10.0%.
7. the preparation method of the Sanguis Draxonis extract cosmetics any one of claim 1-6, it comprises the steps：Will
The Sanguis Draxonis extract is mixed with base material of cosmetics, you can obtain the Sanguis Draxonis extract cosmetics.
8. the cosmetics any one of claim 1-6 are as with following 1) -8) at least one function change
Application in cosmetic：
1) acne pathogenic bacterium are suppressed；
2) anti-acne；
3) DPPH free radicals are removed；
4) ABTS free radicals are removed；
5) antioxidation；
6) defying age；
7) suppress the activity of tryrosinase；
8) whitening.
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| CN110638728A (en) * | 2019-11-14 | 2020-01-03 | 广州一一生物技术有限公司 | Skin care composition for removing acne and lightening acne marks and preparation method and application thereof |
| CN114917166A (en) * | 2022-04-28 | 2022-08-19 | 澳宝化妆品（惠州）有限公司 | Dragon blood tree fruit extract, bath cream composition thereof, application and application thereof |
| CN114917166B (en) * | 2022-04-28 | 2023-08-11 | 澳宝化妆品（惠州）有限公司 | Dragon blood tree fruit extract, shower gel composition thereof, application and application thereof |
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