CN105434239B - A kind of application of skin lightening compositions containing natural botanical source in cosmetics - Google Patents
A kind of application of skin lightening compositions containing natural botanical source in cosmetics Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of application of skin lightening compositions containing natural botanical source in cosmetics.The skin lightening compositions contain gadol extract and mulberry-leaf extract as whitening active component.The gadol extract accounts for the 0.5~5.0% of cosmetics total amount；The mulberry-leaf extract accounts for the 0.5~5.0% of cosmetics total amount.The gadol extract and the mulberry-leaf extract are that the ratio of 3:1~2 is mixed by weight percentage.Application of skin lightening compositions of the present invention containing natural botanical source in cosmetics, containing natural material safe to the human body, gadol extract and mulberry-leaf extract are simultaneously applied in skin-lightening cosmetic, and have inhibiting effect to tyrosinase activity.
Description
Technical field
The present invention relates to a kind of cosmetics, belong to daily use chemicals skin-protection product technical field, contain root of kirilow rhodiola more particularly to one kind
Extract (INCI title: RHODIOLA CRENULATA ROOT EXTRACT) and Mori folium extract (INCI title: MORUS
ALBA LEAF EXTRACT) composite skin care product and its application in skin-lightening cosmetic.
Background technique
In China, skin care item market has nearly 30% cosmetics all to belong to whitening class product.One three ugly traditional concepts of white screening,
People never stop the pursuit of whitening, but skin-lightening cosmetic exposes the heavy metals exceeding standards problem such as mercury, lead in succession in recent years, so that
Growing interest of the safety of skin-lightening cosmetic by consumer, the whitening active ingredients for developing efficiency natural also become cosmetics
The important topic of research and development.
The skin complexion of the mankind is determined by various factors, these factors include the melanocyte for generating melanin
Activity, the distribution of blood vessel, the thickness of skin, pigment, wherein melanin influences skin complexion maximum, and the content of melanin is skin
The important factor in order of skin shade.The content of melanin is more, and the colour of skin of skin is more black.Thus, it is possible to play inhibition
The substance of melanin production is considered as having the function of skin whitening.
There are many reason of causing dermal melanin to generate, such as inherent cause and environmental factor, and its generational verctor phase
Work as complexity.Result of study substantially thinks that its origin cause of formation is at present: the tyrosine in Skin Cell under the action of tyrosinase,
DOPA, DOPA quinone are generated, DOPA quinone is polymerized to Indole-5.6-quinone and ultimately forms using a series of metabolic response
Melanin.
Dermal melanin cell tissue by melanin transfer into Epidermal basal layer cells, with the metabolism of cell
It is brought in cuticula, finally with angular cell detachment.The growth and when being unevenly distributed if dermal melanin is overrun, will result in
Local skin is excessively black and pigmentation, dermal melanin occurs.Tyrosinase is that one kind is widely present in animal and plant body and micro- life
The metalloenzyme of cupric in object is the key enzyme of organism synthesis of melanin, controls the forming process of melanin, level of activity
It plays a major role to the deposition of pigment, by inhibiting its activity that can inhibit the generation of melanin, thus tyrosinase inhibitor
It is widely used in cosmetic industry as skin whitener.
At present both at home and abroad for the whitening agent of skin mainly all to inhibit based on tyrosinase, tyrosinase inhibitor is commonly used
Mainly there are quinhydrones, kojic acid, arbutin, ascorbic acid, licorice etc., these whitening agents have some shortcomings.Such as hydrogen
The cytotoxicity of quinone and kojic acid, skin irritation are larger；The Percutaneously absorbable of kojic acid and ascorbic acid is poor, is unable to give full play it
Effect；Kojic acid, arbutin, ascorbic acid are unstable, oxidizable, degradation and discoloration；Whitening product easy to change is not easy to be consumed
Person receives, and is difficult to be commercialized.In whitening and anti-aging product, tartaric acid is common skin renewal promotor, but tartaric acid is to skin
Skin has certain stimulation, and it is more sensitive to ultraviolet light that long-time service will lead to skin.
Root of kirilow rhodiola (scientific name: Rhodiola rosea L.), alias: Rhodiola rosea sweeps sieve Ma boolean (hiding name) etc.；For
Herbaceos perennial, it is 10-20 centimetres high.Root thickness are strong, and cone, meat is isabelline, and rootstock has most fibrous roots, and rhizome is short,
Thick shape, cylindrical, the squamaceous leaf arranged by most imbricates.Be grown in 1800-2500 meters of height above sea level it is high and cold contamination-freely
Band, growing environment is severe, thus has very strong vitality and special adaptability.Can make it is medicinal, can tonifying Qi clearing lung-heat, benefit
Intelligence nourishing heart is to act on extensive Chinese medicine simply.Also there is very big cosmetic result, skin care item can be made, it is also edible.Root of kirilow rhodiola extracts
Object is formed using the root of kirilow rhodiola for being known as " plateau ginseng " as raw material by advanced technologies Hydrolysis kinetics, contains a large amount of root of kirilow rhodiola
The antioxidant such as glucoside and Rosavin and nutritional ingredient abundant have good anti-radiation and anti-oxidation efficacy, can effectively subtract
The few damage of ray radiation or nuclear radiation to Skin Cell.Rhodioloside superoxide dismutase activity with super strength, can reduce
Ultraviolet light and chemical substance induce generated damage of the free radical to skin histology, to play the work of anti-wrinkle and anti-aging
With.Gadol extract can inhibit tyrosinase activity simultaneously, prevent melanin from being formed, skin whitening.
Mulberry leaf (Mulberry Leaf), scientific name: Folium Mori.Chinese medicine name is the dried leaf of moraceae plants mulberry, is silkworm
Conventional food also known as mulberry, thorn mulberry, mulberry fruit tree, yellow wood leaf etc., mulberry tree is planted in China north and south various regions extensively, and mulberry yield is rich
It is rich.Mulberry-leaf extract is that the blade of moraceae plants mulberry is formed by Hydrolysis kinetics, yellow rich in mulberry leaf polysaccharide, mulberry leaf in extract
The several physiological active substances such as ketone, mulberry leaf polyphenol.Mulberry-leaf extract reduces dermal melanin shape by inhibiting tyrosinase activity
At, improve skin physiology function, moistens white light spot, meanwhile, there are also anti-inflammatory antibacterial effect, extracts to be applied to skin care item for mulberry leaf
In, treatment whelk is also had a better effect.
Therefore, safe and effective tyrosinase inhibitor how is found from natural plant extracts applied to whitening
Cosmetic has become the hot spot technology problem of insider's research.
Summary of the invention
The object of the present invention is to provide a kind of application of skin lightening compositions containing natural botanical source in cosmetics,
It contains natural material safe to the human body, gadol extract and mulberry-leaf extract and applies in skin-lightening cosmetic, and right
Tyrosinase activity has inhibiting effect.
A kind of application of skin lightening compositions containing natural botanical source in cosmetics, the skin lightening compositions
Contain gadol extract and mulberry-leaf extract as whitening active component.
By weight percentage, the gadol extract accounts for the 0.5~5.0% of cosmetics total amount；The mulberry leaf extract
Object accounts for the 0.5~5.0% of cosmetics total amount.
The gadol extract and the mulberry-leaf extract are that the ratio of 3:1~2 is mixed by weight percentage.
The gadol extract is rhodiola extract, and the preparation process used is as follows:
It takes root of kirilow rhodiola to crush, is placed in container, extracted three times with the ethyl alcohol of 8~15 times of inventorys, extract 1~3h every time,
Combined extract recycles ethyl alcohol, stand cooling 18~for 24 hours after, filter, filtrate is rhodiola extract.
The mulberry-leaf extract is Mori folium extract, and the preparation process used is as follows:
It takes mulberry leaf to crush, is placed in container, extracted three times with the ethyl alcohol of 9~20 times of inventorys, extract 1~3h every time, closed
And extracting solution, recycle ethyl alcohol, stand cooling 18~for 24 hours after, filter, filtrate is Mori folium extract.
The cosmetics include whitening cream, moisture retention water, skin whitener.
Application of the skin lightening compositions in whitening cream, by rhodiola extract and Mori folium extract by weight hundred
Divide than being after the ratio of 3:1~2 is mixed, to be added in whitening emulsion matrix as whitening active component, the whitening is living
Property component accounts for the 1.0~10.0% of whitening cream total amount, preferably 0.5~5.0%.
The application of skin lightening compositions function in moisture retention water, by rhodiola extract and Mori folium extract by weight
Amount percentage is after the ratio of 3:1~2 is mixed, to be added in moisturizing water-based as whitening active component, the whitening
Active component accounts for the 0.5~5.0% of moisturizing water inventory.
Application of the skin lightening compositions in skin whitener, by rhodiola extract and Mori folium extract by weight hundred
Divide than being after the ratio of 3:1~2 is mixed, to be added in skin whitener as whitening active component, the whitening active component
Account for the 0.5~5.0% of skin whitener total amount.
By above-mentioned technical proposal, the present invention has the advantage that is with beneficial effect:
Skin whitening care cosmetics composition of the invention, containing natural material safe to the human body, gadol extract and mulberry
Leaf extract is simultaneously applied in skin-lightening cosmetic, and the gadol extract and mulberry-leaf extract specifically include for inhibiting junket ammonia
The ingredient of sour enzyme has significant inhibitory effect to the activity of tyrosinase.
Detailed description of the invention
Fig. 1 is human body whitening evaluation result comparative diagram of the invention.
Specific embodiment
The skin-whitening of the invention containing natural botanical source is combined below by way of specific preferred embodiment combination attached drawing
Application of the object in cosmetics, is described in further detail, but embodiments of the present invention are not limited to that.Following embodiment
In rhodiola extract, Mori folium extract be voluntarily extract be prepared.
1 natural composition whitening cream of embodiment
A kind of application of skin lightening compositions containing natural botanical source in whitening emulsion cosmetics, the original of whitening cream
Expect that component and content are as shown in table 1 below.
A kind of whitening dairy milk starting material formula containing natural plant extracts of table 1
Manufacture craft is as follows:
1) every in precise A phase, it is heated to 75-80 DEG C and stirs evenly, keep the temperature 20min, it is spare；
2) every in precise B phase, it is heated to 75-80 DEG C and stirs evenly, keep the temperature 20min, it is spare；
3) A phase is pumped into emulsion pot, temperature maintains 80 DEG C, opens homogeneous stirring, and mixing speed is 20 turns/min, will
B phase is pumped into emulsion pot, addition C phase raw material, after homogeneous 5min, is further continued for stirring 15min；
4) 40 DEG C are cooled to, the items in D phase is sequentially added, persistently stirs evenly, be cooled to room temperature.
Apply 2 natural composition skin whitening, moisturizing water
A kind of application of skin lightening compositions containing natural botanical source in skin whitening, moisturizing aquation cosmetic, the skin whitening, moisturizing
The raw material components and content of water are as shown in table 2 below.
A kind of skin whitening, moisturizing water composition of raw materials containing natural plant extracts of table 2
| Material name | Mass percent % |
| 1,3 butanediols | 3.00 |
| D panthenol | 0.50 |
| Hyaluronic acid | 0.02 |
| Glycerol | 3.00 |
| De Minshu | 0.05 |
| Rhodiola extract | 3.00 |
| Mori folium extract | 2.00 |
| Deionized water | Add to 100 |
Manufacture craft is as follows:
Above-mentioned each component is accurately weighed, is added sequentially in deionized water, is uniformly mixed.
3 natural composition skin whitener of embodiment
A kind of application of skin lightening compositions containing natural botanical source in whitening cream cosmetics, the raw material of the skin whitener
Component and content are as shown in table 3 below.
A kind of skin whitener composition of raw materials containing natural plant extracts of table 3
Manufacture craft is as follows:
1) every in precise A phase, it is heated to 75-80 DEG C and stirs evenly, keep the temperature 20min, it is spare；
2) every in precise B phase, it is heated to 75-80 DEG C and stirs evenly, keep the temperature 20min, it is spare；
3) B phase being pumped into emulsion pot, temperature maintains 80 DEG C, opens homogeneous and stirring, and mixing speed is 20 turns/min,
A phase is slowly added into B phase, after homogeneous 5min, then persistently stirs 15min；
4) 40 DEG C are cooled to, C phase is sequentially added, persistently stirs evenly, be cooled to room temperature.
Effete test embodiment 1
The present inventor extracts composition (gadol extract and mulberry-leaf extract by 3:2 be combined), addition to natural
In face cream, to effectively melanin production capable of being blocked to test:
1) composition of raw materials and manufacture craft of 3 natural composition skin whitener of embodiment are selected in this experiment, and production, which contains, naturally to be mentioned
The face cream of composition is taken, blank control face cream sample is made in the same manner.
2) the skin-whitening performance test experiment of natural extract face cream:
3) it is tested for selecting volunteer of skin health of 40 each age levels or so region inner forearm 3cm × 3cm
Sample to be tested prepared by embodiment 3 is smeared in position, side, and blank control sample is smeared in the other side.Early daily, evening respectively uses 1 time,
It totally 8 weeks, avoids being washed with water after smearing.Respectively black using skin that is preceding and being produced after 1 week with CK electronics corporation of Germany
Pigment tester checks the melanin content in skin.
Dermal melanin change rate is calculated as follows: the dermal melanin measured after melanin change rate=smearing sample contains
Dermal melanin content × 100% measured before amount/smearing sample.
Experiments have shown that: containing the natural shield for extracting composition (gadol extract and mulberry-leaf extract are combined by 3:2)
Skin frost can effectively block melanin production, play white-skinned face function, it is (red containing composition is naturally extracted that human efficiency evaluates proof
Red-spotted stonecrop extract and mulberry-leaf extract are combined by 3:2) dermal compositions can have the effect for brightening skin.
Effete test embodiment 2
The dermatoglyph degree performance test of natural extract face cream is tested:
The composition of raw materials and manufacture craft of 3 natural composition skin whitener of embodiment are selected in this experiment, and production is extracted containing natural
Blank control face cream sample is made in the face cream of composition in the same manner.
40 each age levels are selected, there is different degrees of dermatoglyph on the face.It is early after subject cleans skin daily
Evening is respectively used continuously 6 weeks with a natural extract face cream, naked eye dermatoglyph variation effect.There is out-of-flatness skin in face
The region volunteer 3cm × 3cm of skin is recipient site, and sample to be tested prepared by embodiment 3 is smeared in side, and blank is smeared in the other side
Control sample.Early daily, evening respectively uses 1 time, 6 weeks totally.Using the preceding and observation skin flat conditions change after 1 week respectively
Change.Dermatoglyph degree effect criterion are as follows: effective: the smooth > 60% of wrinkle area, the colour of skin is obviously thin out；It is effective: skin wrinkle
The smooth > 30% of line area, the colour of skin is thin out；Invalid: the smooth < 30% of wrinkle of skin area, colour of skin variation are unobvious.
After face cream 6 weeks of the natural extraction composition that embodiment 3 provides are used continuously in user, significant effect is accounted for
70%, responder accounts for 30%, no an example nonresponder.
Experiments have shown that: this natural composition also has excellent antioxygenic property, can effectively clear free radical, preferably prolongs
Slow aging, reduces the effect of dermatoglyph degree.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
Without departing from the technical solutions of the present invention, to the above embodiments according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (6)
1. a kind of skin lightening compositions containing natural botanical source are preparing the application in cosmetics, it is characterised in that: described
Skin lightening compositions contain gadol extract and mulberry-leaf extract as whitening active component；The gadol extract accounts for
The 0.5~5.0% of cosmetics total amount；The mulberry-leaf extract accounts for the 0.5~5.0% of cosmetics total amount；The root of kirilow rhodiola extracts
Object and the mulberry-leaf extract are that the ratio of 3:1~2 is mixed by weight percentage；The gadol extract is root of kirilow rhodiola
Extracting solution, the preparation process used are as follows:
It takes root of kirilow rhodiola to crush, is placed in container, extracted three times with the ethyl alcohol of 8~15 times of inventorys, extract 1~3h every time, merged
Extracting solution recycles ethyl alcohol, stand cooling 18~for 24 hours after, filter, filtrate is rhodiola extract；
The mulberry-leaf extract is Mori folium extract, and the preparation process used is as follows:
It takes mulberry leaf to crush, is placed in container, extracted three times with the ethyl alcohol of 9~20 times of inventorys, extract 1~3h every time, merging mentions
Take liquid, recycle ethyl alcohol, stand cooling 18~for 24 hours after, filter, filtrate is Mori folium extract.
2. the skin lightening compositions according to claim 1 containing natural botanical source are preparing the application in cosmetics,
It is characterized by: the cosmetics are selected from whitening cream, moisture retention water, skin whitener.
3. the skin lightening compositions according to claim 2 containing natural botanical source are preparing the application in cosmetics,
It is characterized by: application of the skin lightening compositions in whitening cream, by rhodiola extract and Mori folium extract by weight
Amount percentage is after the ratio of 3:1~2 is mixed, to be added in whitening emulsion matrix as whitening active component, the beauty
White active component accounts for the 1.0~10.0% of whitening cream total amount.
4. the skin lightening compositions according to claim 3 containing natural botanical source are preparing the application in cosmetics,
It is characterized by: the whitening active component accounts for the 0.5~5.0% of whitening cream total amount.
5. the skin lightening compositions according to claim 2 containing natural botanical source are preparing the application in cosmetics,
It is characterized by: application of the skin lightening compositions in moisture retention water, by rhodiola extract and Mori folium extract by weight
Amount percentage is after the ratio of 3:1~2 is mixed, to be added in moisturizing water-based as whitening active component, the whitening
Active component accounts for the 0.5~5.0% of moisturizing water inventory.
6. the skin lightening compositions according to claim 2 containing natural botanical source are preparing the application in cosmetics,
It is characterized by: application of the skin lightening compositions in skin whitener, by rhodiola extract and Mori folium extract by weight
Amount percentage is after the ratio of 3:1~2 is mixed, to be added in skin whitener as whitening active component, the whitening active
Component accounts for the 0.5~5.0% of skin whitener total amount.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106806247A (en) * | 2016-11-01 | 2017-06-09 | 田鹏新 | A kind of skin cream containing red pomegranate gadol extract and preparation method thereof |
| CN107137301A (en) * | 2017-04-14 | 2017-09-08 | 广州合诚三先生物科技有限公司 | A kind of whitening anti-aging natural plant composition and its application |
| CN107485644A (en) * | 2017-08-14 | 2017-12-19 | 佛山实瑞先导材料研究院（普通合伙） | A kind of antibacterial anti-inflammatory agent and its application |
| CN108272743A (en) * | 2018-04-20 | 2018-07-13 | 广州赛莱拉干细胞科技股份有限公司 | Lightening compositions, cosmetics, cosmetics preparation method and system |
| CN111419747A (en) * | 2020-04-18 | 2020-07-17 | 北温草生物科技(上海)有限公司 | Chinese herbal medicine composition for whitening and brightening skin |
| CN112353732A (en) * | 2020-12-23 | 2021-02-12 | 现代百朗德生物科技(江苏)有限公司 | Whitening mask containing rhodiola rosea extract, arbutin and nicotinamide and preparation method thereof |
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