CN105434239A - Application of skin whitening composition containing natural plant source to cosmetics - Google Patents
Application of skin whitening composition containing natural plant source to cosmetics Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses application of a skin whitening composition containing a natural plant source to cosmetics. Rhodiola extract and mulberry leaf extract are contained in the skin whitening composition to serve as whitening active components. The mass of the rhodiola extract accounts for 0.5-5.0% of the total mass of the cosmetics, and the mass of the mulberry leaf extract accounts for 0.5-5.0% of the total mass of the cosmetics. The rhodiola extract and the mulberry leaf extract are mixed according to a weight percentage ratio of 3:(1-2). According to the application of the skin whitening composition containing the natural plant source to the cosmetics, the skin whitening composition contains natural raw materials rhodiola extract and mulberry leaf safe to the human body, is applied to the whitening cosmetics, and has an inhibiting effect on tyrosinase activity.
Description
Technical field
The present invention relates to a kind of cosmetics, belong to daily use chemicals skin-protection product technical field, particularly relate to a kind of containing Radix Rhodiolae extract (INCI title: RHODIOLACRENULATAROOTEXTRACT) and the composite skin care product of Mori folium extract (INCI title: MORUSALBALEAFEXTRACT) and the application in skin-lightening cosmetic thereof.
Background technology
In China, skin care item market has the cosmetics of nearly 30% all to belong to whitening series products.One hides three ugly traditional views in vain, the pursuit of people to whitening never stops, but skin-lightening cosmetic exposes the heavy metals exceeding standard such as hydrargyrum, lead problem in succession in recent years, make the safety of skin-lightening cosmetic be subject to the growing interest of consumer, the whitening active ingredients of exploitation efficiency natural also becomes the important topic of cosmetics research and development.
The skin complexion of the mankind is determined by various factors, these factors comprise produce melanic melanocyte activity, the distribution of blood vessel, the thickness of skin, pigment, wherein melanin has the greatest impact to skin complexion, and melanic content is the important factor in order of the skin color depth.Melanic content is more, and the colour of skin of skin is more black.Thus, the material that can play check melanin generation is regarded as having the effect of skin whitening.
The reason causing dermal melanin to generate has multiple, and as inherited genetic factors and environmental factors, and its generational verctor is quite complicated.Current result of study thinks that its origin cause of formation is substantially: the tyrosine in Skin Cell is under the effect of tryrosinase, and generate DOPA, DOPA quinone, DOPA quinone, again through a series of metabolic response, is polymerized to Indole-5.6-quinone and finally forms melanin.
Melanin transfer in Epidermal basal layer cells, is brought to along with the metabolism of cell in horny layer by dermal melanin cell tissue, finally with angular cell detachment.If dermal melanin is overrun when growth and skewness, local skin will be caused to cross black and pigmentation, occur dermal melanin.Tryrosinase is a kind of metalloenzyme being extensively present in cupric in animal and plant body and microorganism, it is the key enzyme of organism synthesis of melanin, control melanic forming process, the deposition of its level of activity to pigment plays a major role, by suppressing its activity can the generation of check melanin, thus tyrosinase inhibitor be widely used in cosmetic industry as skin whitener.
The domestic and international whitening agent for skin is main all based on restraint of tyrosinase at present, and conventional tyrosinase inhibitor mainly contains hydroquinone, kojic acid, arbutin, ascorbic acid, Radix Glycyrrhizae extract etc., and these whitening agents have some shortcomings part.As larger in the cytotoxicity of hydroquinone and kojic acid, skin irritation; The Percutaneously absorbable of kojic acid and ascorbic acid is poor, cannot give full play to its effect; Kojic acid, arbutin, ascorbic acid are unstable, oxidizable, degraded and variable color; Allochroic whitening product, is not easily esthetically acceptable to the consumers, and is difficult to commercialization.In whitening and anti-aging product, fruit acid is conventional skin renewal promoter, but fruit acid has certain stimulation to skin, and life-time service can cause skin more responsive to ultraviolet light.
Radix Rhodiolae (formal name used at school: RhodiolaroseaL.), another name: Rhodiola rosea L., sweeps sieve agate boolean (Tibetan name) etc.; For herbaceos perennial, high 10-20 centimetre.Root is sturdy, conical, and meat is isabelline, and the most fibrous root of collar portion tool, rhizome is short, thick shape, cylindrical, by the lepidiod leaf that most imbricate arranges.Growth is in the high and cold pollution-free area of height above sea level 1800-2500 meters, and its growing environment is severe, thus has very strong vitality and special adaptability.Can do medicinal, can QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae is nourished heart, and is to act on Chinese medicine widely simply.Also there is very large cosmetic result, can skin care item be made, also edible.Radix Rhodiolae extract is to be described as the Radix Rhodiolae of " plateau Radix Ginseng " for raw material, form through advanced technologies Hydrolysis kinetics, containing antioxidant and abundant nutritional labelings such as a large amount of rhodiolosides and Rosavins, there is good radioprotective and anti-oxidation efficacy, effectively can reduce x radiation x or radioprotective to the damage of Skin Cell.It is active that rhodioloside has superpower superoxide dismutase, can reduce the damage that ultraviolet and chemical substance induce the radical pair skin histology produced, thus play the effect of wrinkle removal and slow down aging.Simultaneously Radix Rhodiolae extract can restraint of tyrosinase active, stop melanin to be formed, skin whitening.
Folium Mori (MulberryLeaf), formal name used at school: FoliumMori.Chinese medicine name is the dried leaves of moraceae plants Mulberry, is the conventional food of silkworm, and have another name called a Mulberry, Jing Sang, Fructus Mori tree, yellow wood leaf etc., mulberry is extensively planted in various places, China north and south, and mulberry yield enriches.Folium Mori extract is that the blade of moraceae plants Mulberry forms through Hydrolysis kinetics, is rich in the several physiological active substances such as polysaccharides of Folium Mori, flavones in mulberry leaves, mulberry leaf polyphenol in extract.Folium Mori extract is active by restraint of tyrosinase, reduces dermal melanin and is formed, improve skin physiology function, moisten white light speckle, and meanwhile, the effect that Folium Mori also have antiinflammatory antibacterial, its extract is applied in skin care item, also has good curative effect for treatment comedo.
Therefore, from natural plant extracts, how to find safe and effective tyrosinase inhibitor be applied to the hot spot technology difficult problem that skin-lightening cosmetic has become insider's research.
Summary of the invention
The object of this invention is to provide a kind of application of skin lightening compositions in cosmetics containing natural botanical source, it contains the natural material to human-body safety, Radix Rhodiolae extract and Folium Mori extract are also applied in skin-lightening cosmetic, and have inhibitory action to tyrosinase activity.
Containing the application of skin lightening compositions in cosmetics of natural botanical source, described skin lightening compositions contains Radix Rhodiolae extract and Folium Mori extract as whitening active component.
By weight percentage, described Radix Rhodiolae extract accounts for 0.5 ~ 5.0% of cosmetics total amount; Described Folium Mori extract accounts for 0.5 ~ 5.0% of cosmetics total amount.
Described Radix Rhodiolae extract and described Folium Mori extract are by weight percentage for the ratio of 3:1 ~ 2 mixes.
Described Radix Rhodiolae extract is Radix Rhodiolae extracting solution, and its preparation technology adopted is as follows:
Get Radix Rhodiolae to pulverize, be placed in container, with the ethanol extraction three times of 8 ~ 15 times of inventorys, extract 1 ~ 3h, merge extractive liquid, at every turn, reclaim ethanol, after standing cooling 18 ~ 24h, sucking filtration, filtrate is Radix Rhodiolae extracting solution.
Described Folium Mori extract is Mori folium extract, and its preparation technology adopted is as follows:
Get Folium Mori to pulverize, be placed in container, with the ethanol extraction three times of 9 ~ 20 times of inventorys, extract 1 ~ 3h, merge extractive liquid, at every turn, reclaim ethanol, after standing cooling 18 ~ 24h, sucking filtration, filtrate is Mori folium extract.
Described cosmetics comprise whitening breast, moisture retention water, skin whitener.
Described skin lightening compositions is in the application in whitening Ruzhong, after the ratio being 3:1 ~ 2 by weight percentage by Radix Rhodiolae extracting solution and Mori folium extract mixes, join in whitening emulsion substrate as whitening active component, described whitening active component accounts for 1.0 ~ 10.0%, preferably 0.5 ~ 5.0% of whitening breast total amount.
The application of described skin lightening compositions function in moisture retention water, after the ratio being 3:1 ~ 2 by weight percentage by Radix Rhodiolae extracting solution and Mori folium extract mixes, join in moisture retention water substrate as whitening active component, described whitening active component accounts for 0.5 ~ 5.0% of moisture retention water total amount.
The application of described skin lightening compositions in skin whitener, after the ratio being 3:1 ~ 2 by weight percentage by Radix Rhodiolae extracting solution and Mori folium extract mixes, join in skin whitener as whitening active component, described whitening active component accounts for 0.5 ~ 5.0% of skin whitener total amount.
By technique scheme, the advantage that the present invention has and beneficial effect are:
Skin whitening care cosmetics compositions of the present invention, it contains the natural material to human-body safety, Radix Rhodiolae extract and Folium Mori extract are also applied in skin-lightening cosmetic, described Radix Rhodiolae extract and Folium Mori extract specifically comprise the composition for restraint of tyrosinase, and it has significant inhibition to the activity of tryrosinase.
Accompanying drawing explanation
Fig. 1 is human body whitening evaluation result contrast figure of the present invention.
Detailed description of the invention
Below by way of concrete preferred embodiment by reference to the accompanying drawings to the application of skin lightening compositions in cosmetics containing natural botanical source of the present invention, be described in further detail, but embodiments of the present invention are not limited in this.Radix Rhodiolae extracting solution in following examples, Mori folium extract are to extract voluntarily and prepare.
embodiment 1 natural composition whitening breast
Contain the application of skin lightening compositions at whitening emulsion cosmetics for natural botanical source, raw material components and the content of this whitening breast are as shown in table 1 below.
One kind, table 1 is containing the whitening dairy milk starting material formula of natural plant extracts
Processing technology is as follows:
1) every in precise A phase, be heated to 75-80 DEG C and stir, insulation 20min, for subsequent use;
2) every in precise B phase, be heated to 75-80 DEG C and stir, insulation 20min, for subsequent use;
3) by A phase suction emulsifying pot, temperature maintains 80 DEG C, and open homogenizing and stir, mixing speed is 20 turns/min, by B phase suction emulsifying pot, adds C phase raw material, after homogenizing 5min, then continues to stir 15min;
4) be cooled to 40 DEG C, what add in D phase successively is every, and Keep agitation is even, cool to room temperature.
2 natural composition whitening skin and preserving moisture water are executed in enforcement
Contain the application of skin lightening compositions in whitening skin and preserving moisture aquation cosmetic for natural botanical source, raw material components and the content of this whitening skin and preserving moisture water are as shown in table 2 below.
One kind, table 2 is containing the whitening skin and preserving moisture water composition of raw materials of natural plant extracts
| Material name | Mass percent % |
| 1,3 butanediols | 3.00 |
| D pantothenylol | 0.50 |
| Hyaluronic acid | 0.02 |
| Glycerol | 3.00 |
| De Minshu | 0.05 |
| Radix Rhodiolae extracting solution | 3.00 |
| Mori folium extract | 2.00 |
| Deionized water | Add to 100 |
Processing technology is as follows:
Accurately take above-mentioned each component, join successively in deionized water, mix homogeneously.
embodiment 3 natural composition skin whitener
Contain the application of skin lightening compositions at whitening cream cosmetics for natural botanical source, raw material components and the content of this skin whitener are as shown in table 3 below.
One kind, table 3 is containing the skin whitener composition of raw materials of natural plant extracts
Processing technology is as follows:
1) every in precise A phase, be heated to 75-80 DEG C and stir, insulation 20min, for subsequent use;
2) every in precise B phase, be heated to 75-80 DEG C and stir, insulation 20min, for subsequent use;
3) by B phase suction emulsifying pot, temperature maintains 80 DEG C, and open homogenizing and stirring, mixing speed is 20 turns/min, A phase is slowly added in B phase, after homogenizing 5min, then Keep agitation 15min;
4) be cooled to 40 DEG C, add C phase successively, Keep agitation is even, is cooled to room temperature.
effect test example 1
The present inventor, to natural extract compositions (Radix Rhodiolae extract and Folium Mori extract combine by 3:2), is added in protective skin cream, tests effectively blocking melanin generation:
1) composition of raw materials and the processing technology of embodiment 3 natural composition skin whitener is selected in this experiment, makes the protective skin cream containing natural extract compositions, obtains blank protective skin cream sample according to identical method.
2) the skin-whitening performance test experiment of natural extract protective skin cream:
3) the inner forearm 3cm × 3cm region, volunteer left and right selecting the skin health of 40 each age levels is recipient site, and testing sample prepared by embodiment 3 is smeared in side, and opposite side smears blank control sample.Morning every day, each use in evening 1 time, totally 8 weeks, avoid after smearing being washed.Respectively before use and after 1 week with the dermal melanin tester that German CK electronics corporation produces, check melanin content in skin.Be calculated as follows dermal melanin rate of change: dermal melanin content × 100% recorded before the dermal melanin content recorded after melanin rate of change=smear sample/smear sample.
Experiment proves: the protective skin cream containing natural extract compositions (Radix Rhodiolae extract and Folium Mori extract combine by 3:2) effectively can block melanin and generate, play white-skinned face function, human efficiency evaluates proves can have containing natural extract compositions (Radix Rhodiolae extract and Folium Mori extract combine by 3:2) dermal compositions the effect brightening skin.
effect test example 2
The present inventor tests reduction skin texture natural composition (Radix Rhodiolae extract and Folium Mori extract combine by 3:2), and experimental data is as follows:
The antioxidant activity test of natural composition:
1) reagent and instrument
2) DPPH (Sigma) system is prepared with dehydrated alcohol; α tocopherol (Sigma), other reagent is domestic analytical pure.The two light spectrophotometer (Japanese Shimadzu Corporation) of UV-1601 UV, visible light.
3) method: compound concentration is sample, the positive control Vc storing solution of 1mM, is diluted to 40,80,120,160,200 μMs with dehydrated alcohol; Get DPPH1.4mg and add the DPPH solution that namely 17.5mL dehydrated alcohol obtains 0.2mmol/L; The sample solution (test material) getting the above-mentioned variable concentrations of 100 μ L adds in 96 hole ELISA Plate, then adds the DPPH solution 100 μ L of matching while using, makes sample effect ultimate density be 20,40,60,80,100 μMs.The absorbance of working sample under 517nm wavelength (As) after ELISA Plate is incubated 30min at 30 DEG C, Simultaneously test does not add sample blank (100 μ L dehydrated alcohol the replace DPPH) light absorption value (Ac) of DPPH free radical reagent and adds DPPH free radical reagent but do not add the light absorption value (Amax) of sample (100 μ L dehydrated alcohol replace sample), and the calculating relative clearance rate of free radical (%)=[1-(As-Ac)/Amax] × 100% also calculates IC50 value.Concrete outcome is with reference to shown in table 4.
The relative clearance rate contrast table of free radical of table 4 different tests material
| Test extracting solution | The relative clearance rate of free radical (%) |
| Arbutin extract | 30.65 |
| Natural extract compositions | 38.70 |
| Radix Astragali extract | 30.88 |
| Semen Coicis extract | 31.50 |
| VC | 26.80 |
As can be seen from Table 4,5 kinds of extracts all have antioxidant activity, and Scavenging ability is suitable with Vc; Wherein, natural extract compositions has best antioxidant activity; As can be seen from table 1 also, in non-oxidizability, the effect of natural extract compositions of the present invention is used alone more excellent than VC, have good complementation and synergism.
effect test example 3
The skin texture degree performance test experiment of natural extract protective skin cream:
Composition of raw materials and the processing technology of embodiment 3 natural composition skin whitener are selected in this experiment, make the protective skin cream containing natural extract compositions, obtain blank protective skin cream sample according to identical method.
Select 40 each age levels, all have skin texture in various degree on the face.After experimenter cleans skin every day, sooner or later respectively use 6 weeks continuously with a natural extract protective skin cream, naked eye skin texture variation effect.Face has volunteer 3cm × 3cm region of out-of-flatness skin to be recipient site, and testing sample prepared by embodiment 3 is smeared in side, and opposite side smears blank control sample.Morning every day, each use in evening 1 time, totally 6 weeks.Rear skin flat conditions of observing changes before use and every 1 week respectively.The criterion of skin texture degree effect is: effective: the smooth > 60% of wrinkle area, and the colour of skin is obviously thin out; Effective: the smooth > 30% of wrinkle of skin area, the colour of skin is thin out; Invalid: the smooth < 30% of wrinkle of skin area, colour of skin change is not obvious.
The protective skin cream of the natural extract compositions using embodiment 3 to provide continuously at user is after 6 weeks, and Be very effective accounts for 70%, and responder accounts for 30%, none routine nonresponder.
Experiment proves: this natural composition also has excellent antioxygenic property, can effective scavenging free radicals, good slow down aging, the effect of reduction skin texture degree.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, therefore everyly do not depart from technical solution of the present invention content, the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (9)
1. containing the application of skin lightening compositions in cosmetics of natural botanical source, it is characterized in that: described skin lightening compositions contains Radix Rhodiolae extract and Folium Mori extract as whitening active component.
2. application according to claim 1, is characterized in that: by weight percentage, described Radix Rhodiolae extract accounts for 0.5 ~ 5.0% of cosmetics total amount; Described Folium Mori extract accounts for 0.5 ~ 5.0% of cosmetics total amount.
3. application according to claim 2, is characterized in that: described Radix Rhodiolae extract and described Folium Mori extract are by weight percentage for the ratio of 3:1 ~ 2 mixes.
4. application according to claim 1, is characterized in that: described Radix Rhodiolae extract is Radix Rhodiolae extracting solution, and its preparation technology adopted is as follows:
Get Radix Rhodiolae to pulverize, be placed in container, with the ethanol extraction three times of 8 ~ 15 times of inventorys, extract 1 ~ 3h, merge extractive liquid, at every turn, reclaim ethanol, after standing cooling 18 ~ 24h, sucking filtration, filtrate is Radix Rhodiolae extracting solution.
5. application according to claim 1, is characterized in that: described Folium Mori extract is Mori folium extract, and its preparation technology adopted is as follows:
Get Folium Mori to pulverize, be placed in container, with the ethanol extraction three times of 9 ~ 20 times of inventorys, extract 1 ~ 3h, merge extractive liquid, at every turn, reclaim ethanol, after standing cooling 18 ~ 24h, sucking filtration, filtrate is Mori folium extract.
6. application according to claim 1, is characterized in that: described cosmetics comprise whitening breast, moisture retention water, skin whitener.
7. application according to claim 6, it is characterized in that: described skin lightening compositions is in the application in whitening Ruzhong, after the ratio being 3:1 ~ 2 by weight percentage by Radix Rhodiolae extracting solution and Mori folium extract mixes, join in whitening emulsion substrate as whitening active component, described whitening active component accounts for 1.0 ~ 10.0%, preferably 0.5 ~ 5.0% of whitening breast total amount.
8. application according to claim 6, it is characterized in that: the application of described skin lightening compositions function in moisture retention water, after the ratio being 3:1 ~ 2 by weight percentage by Radix Rhodiolae extracting solution and Mori folium extract mixes, join in moisture retention water substrate as whitening active component, described whitening active component accounts for 0.5 ~ 5.0% of moisture retention water total amount.
9. application according to claim 6, it is characterized in that: the application of described skin lightening compositions in skin whitener, after the ratio being 3:1 ~ 2 by weight percentage by Radix Rhodiolae extracting solution and Mori folium extract mixes, join in skin whitener as whitening active component, described whitening active component accounts for 0.5 ~ 5.0% of skin whitener total amount.
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| CN106806247A (en) * | 2016-11-01 | 2017-06-09 | 田鹏新 | A kind of skin cream containing red pomegranate gadol extract and preparation method thereof |
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| CN107485644A (en) * | 2017-08-14 | 2017-12-19 | 佛山实瑞先导材料研究院（普通合伙） | A kind of antibacterial anti-inflammatory agent and its application |
| CN108272743A (en) * | 2018-04-20 | 2018-07-13 | 广州赛莱拉干细胞科技股份有限公司 | Lightening compositions, cosmetics, cosmetics preparation method and system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN108272743A (en) * | 2018-04-20 | 2018-07-13 | 广州赛莱拉干细胞科技股份有限公司 | Lightening compositions, cosmetics, cosmetics preparation method and system |
| CN111419747A (en) * | 2020-04-18 | 2020-07-17 | 北温草生物科技(上海)有限公司 | Chinese herbal medicine composition for whitening and brightening skin |
| CN112353732A (en) * | 2020-12-23 | 2021-02-12 | 现代百朗德生物科技(江苏)有限公司 | Whitening mask containing rhodiola rosea extract, arbutin and nicotinamide and preparation method thereof |
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