CN105434256B - A kind of natural lotion, preparation method and applications - Google Patents
A kind of natural lotion, preparation method and applications Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The present invention provides a kind of natural lotion, preparation method and applications.The natural lotion of the present invention includes the component of following parts by weight：0.05 0.3 parts of 5 10 parts of hill gooseberry's lactobacillus-fermented extract, 0.3 1.0 parts of Spiraea thunbergii leaf extract, 27 parts of Germinatus Phragmitis extract, 0.2 1.0 parts of Herba Swertiae bimaculatae extract, 0.3 1.0 parts of natural macromolecular polymer viscosifier, 10 15 parts of polyalcohol and natural plant preservative.Genuine milk liquid energy of the present invention enough removes free radical, inhibits tyrosinase activity, and the effects that promoting the proliferation of skin keratinocytes while reducing the release of histamine, while cell experiment is shown, without cytotoxicity, safety is higher.In the skin care item exploitation of whitening, maintenance effect, there are preferable market prospects.
Description
Technical field
The invention belongs to cosmetic material preparing technical field, more particularly to the preparation of a kind of natural lotion and its repairing
Application in the skin care item such as shield, whitening, crease-resistant.
Background technology
At this stage, fair complexion be always Asian pursue best skin condition, people often through use addition
Product with white-skinned face function ingredient, to obtain preferable whitening effect, therefore whitening product has very big demand
Space.The statistical reports of Min Te companies shows that the first half of the year in 2013 made for 1493 20-49 Sui within past 6 months
The women Internet user of used face protection product, the user that whitening effect is expected to have to product account for 61%, it can be seen that whitening
The demand of product is larger.But adverse reaction caused by cosmetics has the tendency that showed increased, hair dye allergy, freckle removing and whitening
The problem of product has been reported that when containing the problems such as unauthorized substances, and safety is still cosmetic industry and consumer's extensive concern.
The Japan beauty treasured whitening product of the second half year in 2012 causes hickie event duration so far, and victim's number is still increasing.Many
People talks whitening discoloration instantly, when the safety of whitening product becomes Related product exploitation in industry the problem of overriding concern.
In December, 2013, state food pharmaceuticals administration general bureau are to ensure consumer health's equity, and whitening product is included in special use
Way cosmetics management, to more preferably control the security risk of skin-lightening cosmetic.Therefore when exploitation whitening product, addition has whitening
Effect raw material is selected to a mostly important link, makes whitening composition while ensureing whitening effect, safety is
The content of first concern, therefore, the whitening raw material of high security are a trend of Related product exploitation.
Currently, environmental pollution is serious, skin of face is exposed in large quantity of air pollutant, such as vehicle exhaust, ionization spoke
It penetrates, oxygen radical, ultraviolet light, koniology etc., these pollutants generate a large amount of free radicals, be easy to cause skin excessive oxidation,
Cause stimulation and excessive skin injury, or even causes cutaneous lesions.Therefore, skin excessive damage caused by repairing environment pollution
It is an important need for developing such product.
Invention content
The purpose of the present invention is to provide a kind of natural lotion, preparation method and applications.The genuine milk liquid energy of the present invention
The effects that enough removing free radical, inhibit tyrosinase activity, promoting the proliferation of skin keratinocytes, while cell experiment is shown,
There is no cytotoxicity, safety higher.In the skin care item exploitation of whitening, maintenance effect, there are preferable market prospects.
The technical scheme is that：A kind of natural lotion, includes the component of following parts by weight：Hill gooseberry's lactobacillus-fermented
5-10 parts of extract, 0.3-1.0 parts of Spiraea thunbergii leaf extract, 2-7 parts of Germinatus Phragmitis extract, Herba Swertiae bimaculatae extract 0.2-1.0
Part, 0.3-1.0 parts of natural macromolecular polymer viscosifier, 10-15 parts of polyalcohol and 0.05-0.3 parts of natural plant preservative.
Hill gooseberry's lactobacillus-fermented extract is that the juice removed the peel by myrtle fruit is fermented using lactic acid bacteria 48h
Afterwards, after the zymotic fluid 4000r/min centrifugations obtained, supernatant is taken, the liquid obtained using 0.22 micron membrane filter filtration sterilization；
The Spiraea thunbergii leaf extract is the extraction after being heated to reflux using 95% ethyl alcohol by Spiraea thunbergii leaf
Liquid is concentrated, it is dry after be made；
The Germinatus Phragmitis extract is with asparagus spear, after 70% ethyl alcohol extraction, concentrate obtained after concentrated；
The Herba Swertiae bimaculatae extract is that Swertia patens herb uses ethyl acetate room temperature, the extracting solution after dipping is concentrated,
It is made after drying；
Said extracted method is this field conventional extraction techniques.
The natural macromolecular polymer viscosifier is one kind in algin, acacia glue, flaxseed gum, Sunset Abelmoschus Root glue
Or it is several.
The polyalcohol is the one or more of glycerine, butanediol, pentanediol, hexylene glycol.
The natural plant preservative is the one or two of Chinese prickly ash berry extract, rosemary oil.
Above-mentioned each component is commercial product unless otherwise specified.
The preparation method of the natural lotion of the present invention, includes the following steps：
S1：Each component is weighed according to weight proportion；
S2:The natural macromolecular polymer viscosifier deionized water dissolving that will be weighed, heating form liquid one；
S3：Hill gooseberry's lactobacillus-fermented extract, Spiraea thunbergii leaf extract, Germinatus Phragmitis extract, the river deer tooth that will be weighed
Dish extract, polyalcohol are stirred, and obtain thick liquid two；
S4：Liquid two is slowly added into liquid one, stirs, obtains emulsion liquid；
S5：The natural plant preservative weighed is added in the emulsion liquid that temperature is 40 DEG C, as natural lotion.
Preferably, the temperature in the step S2 is 50-75 DEG C.
Preferably, the mixing time in the step S4 is 20-40min.
The present invention also provides application of the natural lotion in preparing maintenance, whitening, crease-resistant skin care item.
The effect of each component in the present invention：
Hill gooseberry is the evergreen shrubs of Myrtaceae Myrtus, is distributed widely in China southeast, is a kind of common
Chinese herbal medicine, complete stool can hyoscines.Civil, fruit carrys out strengthen immunity frequently as a kind of tonic, and with extremely strong anti-
Oxidation activity.Its antioxidant activity, which is attributed to, wherein contains more polyphenol substance.It finds under study for action, the polyphenol in hill gooseberry
Substance content is significantly larger than other fruit and cereal.Polyphenolic substance mainly include flavonoids, phenolic acid, quinine, tannin and its
He.Past report points out there is stronger correlation between polyphenol content and oxidation resistance.General flavone content in hill gooseberry
There is the reason of high anti-oxidation ability for 49.7mg CE/100g and hill gooseberry.(meanwhile containing certain in hill gooseberry's fruit
Polysaccharide, pectic substance and the fat of amount) by the metabolic activity of lactic acid bacteria, experience is delayed up to several weeks in the environment of anaerobic
The process of slowly fermenting, by the carbohydrate and the sugar transition enzyme and amino acid liked at skin in hill gooseberry's fruit, effectively
Ingredient is decomposed and macro, and harmful bacteria and toxin is made to be removed naturally, not only natural but also safety.Meanwhile fermentation makes active ingredient
The effect of becoming being more easy to absorbed small molecule, improving hill gooseberry's extract, keeps the extract permeability more preferable, has stronger
Moisten, repair and anti-oxidation function.
Spiraea thunbergii also known as basilima sorbifolia, belong to the rose family, research shows that the ethanol extract of its fresh leaf is to tyrosinase
Inhibiting effect be more than a concentration of 1mmol/L ursin inhibiting effect, and relative to ursin, which naturally comes
Source has more safety.
Asparagus is rich in a variety of amino acid, protein and vitamin, and content is above general fruit and vegetables, especially reed
The effect of asparagine and trace elements of selenium, molybdenum, chromium, manganese in bamboo shoot etc. have and adjust organism metabolism, improve body immunity；
Flavone compound and polysaccharide are main active skull cap components in asparagus cauline leaf, have anti-oxidant, reparation and other effects.
Swertia patens, which are that one in Gentianaceae is big, to be belonged to, and Swertiamarin is the main component in Gentianaceae Swertia plant
One of, the expansible capillary of Swertiamarin, the enzyme system of activation and promotion Skin Cell improves the biochemical function of skin,
With hair growth disease and beautifying skin agent can be used for.Therefore, Herba Swertiae bimaculatae extract is other than the function and effect excellent to skin,
It can also promote the osmotic absorption of other functional components.
Beneficial effects of the present invention：
(1) a kind of natural lotion is provided, free radical can be removed, inhibited tyrosinase activity, promotes skin keratin
The effects that being proliferated while reducing the release of histamine of cell.
(2) the natural lotion, all the components belong to natural origin, and extracted form natural plant is safe, and absorbability is good,
Significant effect.In use, both effective and safe, irritation is small.
Description of the drawings
Fig. 1 is for the natural lotion of various concentration to the rejection ability of tyrosinase (with VC100mg/mL concentrations versus).
Fig. 2 is influence (with 1mg/ml EGF compared) of the natural lotion of various concentration to human keratinized cell.
Specific implementation mode
For a better understanding of the present invention, with reference to the embodiment content that the present invention is furture elucidated, but the present invention
Content is not limited solely to the following examples, and embodiment is not construed as limiting the scope of the present invention.
Natural constituents extract described in following embodiments is：Hill gooseberry's lactobacillus-fermented extract is to be gone by myrtle fruit
After the juice of skin is using lactic acid bacteria 48h fermentations, after obtained zymotic fluid 4000r/min centrifugations, supernatant is taken, using 0.22 micron
The liquid that membrane filtration degerming obtains；
Spiraea thunbergii leaf extract is by Spiraea thunbergii leaf, and the extracting solution after being heated to reflux using 95% ethyl alcohol is through dense
It is made after contracting, drying；
Germinatus Phragmitis extract is with asparagus spear, after 70% ethyl alcohol extraction, concentrate obtained after concentrated；
Herba Swertiae bimaculatae extract is that Swertia patens herb uses ethyl acetate room temperature, the extracting solution after dipping is concentrated, it is dry after
It is made.
Embodiment 1：
In a container, 0.4g algins is taken to be dissolved in 20g deionized waters, is heated to 65 DEG C and obtains sticky liquid one；
Another container is taken, the asparagus extraction of 5.5g hill gooseberry's lactic acid fungus extract, 2.5g Spiraea thunbergiis leaf extract, 3.0g is added
The river deer tooth grass extract mixing of object, 1.5g, adds 15g butanediols and 2g pentanediols, and deionized water 49.9g is added in dissolving, is mixed
It is even to obtain liquid two；Liquid two is added in liquid one, is cooled down after stirring 30min, when temperature is reduced to 40 DEG C, is added
The Chinese prickly ash berry extract of 0.2g, stirs evenly, and obtains lotion, the as natural lotion with whitening, repairing effect.
The natural lotion of above-mentioned preparation, for having in the skin care item of whitening and reparation, the whitening containing the natural lotion
It is as shown in the table to repair formula frost：
Embodiment 2：
In a container, takes 0.3g acacias glue to be dissolved in 30g deionized waters with 0.1g Sunset Abelmoschus Root glues, be heated to 60 DEG C and obtain
Sticky liquid one；Another container is taken, 7.5g hill gooseberry's lactobacillus-fermented extract, the extraction of 3.0g Spiraea thunbergii leaves is added
Object, the Germinatus Phragmitis extract of 4.0g, mixing after the Herba Swertiae bimaculatae extract of 1.0g, add 10g glycerine, 6g butanediols and 2g oneself two
Alcohol, dissolving add deionized water 35.95g, are uniformly mixed so as to obtain liquid two；Liquid two is added in liquid one, after stirring 25min
Cooling is added the Chinese prickly ash berry extract and 0.05g rosemary oils of 0.1g, stirs evenly, obtain breast when temperature is reduced to 40 DEG C
Liquid, the as natural lotion with whitening, repairing effect.
The natural lotion of above-mentioned preparation is used in the skin care item with whitening and reparation, and the whitening containing the natural lotion is repaiied
Emulsion formula of liquid is as shown in the table：
Embodiment 3：
It in a container, takes 0.5g flaxseed gums, 0.2g acacias peptization in 25g deionized waters, is heated to 60 DEG C and obtains
Sticky liquid one；Another container is taken, 6.0g hill gooseberry's lactobacillus-fermented extract, the extraction of 4.0g Spiraea thunbergii leaves is added
Object, the Germinatus Phragmitis extract of 5.0g, mixing after the Herba Swertiae bimaculatae extract of 2.0g, add, 10g butanediols, 2g pentanediols and 3g oneself
Glycol, dissolving add deionized water 42.1g, are uniformly mixed so as to obtain liquid two；Liquid two is added in liquid one, after stirring 25min
Cooling is added the Chinese prickly ash berry extract and 0.12g rosemary oils of 0.08g, stirs evenly, obtain when temperature is reduced to 40 DEG C
Lotion, the as natural lotion with whitening, repairing effect.
The natural lotion of above-mentioned preparation is used in the skin care item with whitening and reparation, and the whitening containing the natural lotion is repaiied
Multiple essence formula of liquid is as shown in the table：
The influence of test example 1, natural lotion to tyrosinase
Studies have shown that inhibiting tyrosinase, the synthesis of melanin can be inhibited, to reduce the production of melanin in skin
It is raw.This experiment discussion inhibiting effect of the natural lotion of the invention to tyrosinase.
Preparatory work of experiment：
1, laboratory sample：Vitamin C (100mg/mL), various concentration natural lotion (5,10,30,50,70,100mg/
mL)
2, reagent and instrument：Tyrosinase, L-- tyrosine, disodium hydrogen phosphate, sodium dihydrogen phosphate thermostat, ultraviolet spectrometry
Photometer, centrifuge.
3, experimental procedure
Experimental group：600 μ lPBS buffer solutions, 200 μ l tyrosine, 200 μ l are added into EP pipes successively respectively with pipette not
With concentration natural lotion (each a concentration of 5,10,30,50,70,100mg/ml), 200 μ l tyrosinases, 6 EP pipes are put into
Temperature-resistant 30min is kept in 30 DEG C of water-baths.
Control group：Be added successively into EP pipes respectively with pipette 800 μ lPBS buffer solutions, 200 μ l various concentrations it is natural
Lotion (each a concentration of 5,10,30,50,70,100mg/ml), 200 μ l tyrosinases, 6 EP pipes are put into 30 DEG C of water-baths
Keep temperature-resistant 30min.
It waits for that sample liquid-transfering gun is taken out 200 μ l respectively after reaction, is added in 96 orifice plates, each group of sample repeats
3 times, microplate reader is then used to survey the absorbance of each group at 475nm.
Tyrosinase vigor=[(A-B)/A] × l00%
Wherein, " A " is the light absorption value of experimental group, and " B " is the light absorption value of control group.Each experiment do 3 it is parallel.
Experimental result has preferable inhibit as shown in Figure 1, can be seen that natural lotion from experimental data to tyrosinase
Effect, and with the increase of concentration, the inhibiting effect of tyrosinase is enhanced, it can be seen that it, should in a concentration of 100mg/mL
Natural lotion is suitable with vitamin C effect.
The influence of test example 2, natural lotion to human keratinized cell
Bibliography method [Yang Chuntao, Yang Zhanli, Mo Liqiu, Zeng Fanqin, Zhang Meifen, Zhang Hui, Han Yanfang, Hu Fen, Lan Ai
Flat, the strong cyclooxygenase 2s of Chen Peixi, Feng Jian mediate the inflammation damnification effect of the Human keratinocytes of chemical hypoxic induction, in
State's Pharmacological Bulletin, 2011,27 (1)：69-73], using Cell culture invitro technology and tetrazolium bromide (MTT) colorimetric method, compare day
The influence that right lotion grows HACAT and be proliferated with epidermal growth factor.Take natural lotion appropriate, with DMEM in high glucose culture medium
(serum-free) solution makees solvent, the natural lotion of 5,10,30,50,70,100mg/ml is prepared respectively, with a concentration of 1mg/ml's
Epithelical cell growth factor EGF is compared.In 96 orifice plates, it is 2.2 × 10 to immortalize horn cell planting density4A mL-1, often
Hole is inoculated with 100 μ L, after planting plate for 24 hours, tested material is added and handles 48h, subsequently ibid.Negative control group, which uses, is free of any tested material
Containing the serum-free DMEM in high glucose medium treatment for immortalizing horn cell.
The results are shown in Figure 2：From experimental data as can be seen that compared with negative control, EGF is thin with cutin is significantly improved
The effect of born of the same parents' proliferation, meanwhile, natural lotion enhances the proliferation function of horn cell with the increase of concentration, when 50mg/mL
Facilitation is most strong.But with the increase of concentration, natural lotion can influence the growth of cell, and cell survival rate reduces, but still
So it is higher than half lethal concentration (cell survival rate 50%), illustrates that concentration increase does not bring certain cytotoxicity.It can
To find out, genuine milk liquid energy enough promotes the proliferation of horn cell, has certain repair to skin epidermis.
Claims (6)
1. a kind of natural lotion, characterized in that include the component of following parts by weight：Hill gooseberry's lactobacillus-fermented extract 5-10
Part, is naturally divided greatly 0.3-1.0 parts of Spiraea thunbergii leaf extract, 2-7 parts of Germinatus Phragmitis extract, 0.2-1.0 parts of Herba Swertiae bimaculatae extract
0.05-0.3 parts of sub- polymer viscosifier 0.3-1.0 parts, 10-15 parts of polyalcohol and natural plant preservative；
Hill gooseberry's lactobacillus-fermented extract is after the juice of myrtle fruit peeling is fermented using lactic acid bacteria 48h, to obtain
Zymotic fluid 4000r/min centrifugation after, take supernatant, the liquid obtained using 0.22 micron membrane filter filtration sterilization；
The Spiraea thunbergii leaf extract is Spiraea thunbergii leaf, and the extracting solution after being heated to reflux using 95% ethyl alcohol is through dense
It is made after contracting, drying；
The Germinatus Phragmitis extract is concentrate obtained after concentrated after asparagus spear is extracted using 70% ethyl alcohol；
After the Herba Swertiae bimaculatae extract is concentrated using the extracting solution after ethyl acetate normal temperature dipping, dry for Swertia patens herb
It is made.
2. natural lotion as described in claim 1, characterized in that the natural macromolecular polymer viscosifier is seaweed
One or more of glue, acacia glue, flaxseed gum, Sunset Abelmoschus Root glue；
The polyalcohol is the one or more of glycerine, butanediol, pentanediol, hexylene glycol；
The natural plant preservative is the one or two of Chinese prickly ash berry extract, rosemary oil.
3. the preparation method of natural lotion described in claim 1, characterized in that include the following steps：
S1：Each component is weighed according to weight proportion；
S2:The natural macromolecular polymer viscosifier deionized water dissolving that will be weighed, heating form liquid one；
S3：The hill gooseberry's lactobacillus-fermented extract, Spiraea thunbergii leaf extract, Germinatus Phragmitis extract, the Swertia patens that weigh are carried
It takes object, polyalcohol to be stirred, obtains thick liquid two；
S4：Liquid two is slowly added into liquid one, stirs, obtains emulsion liquid；
S5：The natural plant preservative weighed is added in the emulsion liquid that temperature is 40 DEG C, as natural lotion.
4. the preparation method of natural lotion as claimed in claim 3, characterized in that the temperature in the step S2 is 50-75
℃。
5. the preparation method of lotion as claimed in claim 3 natural, characterized in that the mixing time in the step S4 is
20-40min。
6. application of the natural lotion described in claim 1 in preparing maintenance, whitening, crease-resistant skin care item.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106309348A (en) * | 2016-09-18 | 2017-01-11 | 诺斯贝尔化妆品股份有限公司 | Pure-amino-acid mild foam cleansing cream with rice fermentation products |
| CN107233241A (en) * | 2016-12-30 | 2017-10-10 | 海南师范大学 | A kind of preparation method and application of the emulsion containing hill gooseberry |
| CN106860233A (en) * | 2017-01-18 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment antiallergy emulsion |
| CN106860372A (en) * | 2017-02-24 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment repair latex |
| CN106860111A (en) * | 2017-02-24 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment repair latex |
| CN108324636A (en) * | 2018-03-23 | 2018-07-27 | 北京明弘科贸有限责任公司 | A kind of skin care compositions and with careful pore effect cosmetic, preparation method |
| CN108653096B (en) * | 2018-07-11 | 2021-01-05 | 广州弥雅化妆品有限公司 | Daily skin care solution and preparation method thereof |
| CN111374930A (en) * | 2018-12-28 | 2020-07-07 | 山东洁士医疗用品有限公司 | Natural plant asparagus mask essence and preparation method thereof |
| CN111329897B (en) * | 2020-04-13 | 2022-04-15 | 广西壮族自治区兽医研究所 | Method for producing flavone by fermenting myrtle through mixed probiotics |
| CN111789803B (en) * | 2020-08-28 | 2021-11-16 | 江南大学 | Method for improving tyrosinase inhibition effect of asparagus polyphenol through hydrothermal treatment |
| CN113151067B (en) * | 2021-03-31 | 2023-03-24 | 绽妍生物科技有限公司 | Extraction and separation process of lactobacillus fermentation extract |
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Address after: 250101 888 Xinjie street, Ji'nan high tech Zone, Shandong Patentee after: Shandong furida biological Co.,Ltd. Address before: 250101 Shandong Academy of Pharmaceutical Sciences, No. 989 Xinluo street, high tech Zone, Jinan, Shandong Province Patentee before: SHANDONG FREDA BIO-ENGINEERING Co.,Ltd. |