CN110787110A - Composition with hair care effect and preparation method thereof - Google Patents
Composition with hair care effect and preparation method thereof Download PDFInfo
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- CN110787110A CN110787110A CN201911249802.5A CN201911249802A CN110787110A CN 110787110 A CN110787110 A CN 110787110A CN 201911249802 A CN201911249802 A CN 201911249802A CN 110787110 A CN110787110 A CN 110787110A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention relates to daily chemical products, in particular to a composition with a hair care effect and a preparation method thereof. The composition with the hair care effect comprises the following raw materials in parts by weight: 10-37 parts of ginger extract and 0.1-9 parts of repairing agent; the repairing agent is at least one of rice fermentation filtrate, millet fermentation filtrate, wheat fermentation filtrate and oat fermentation filtrate. The composition with the hair care effect solves the inherent problems that the effect of a hair care product is not ideal and the scalp problem cannot be effectively improved, can promote the absorption of skin tissue nutrient components and the excretion of waste substances, improves the scalp ecology, contains rich trace elements, and is beneficial to hair strengthening and hair growth.
Description
Technical Field
The invention relates to the technical field of daily chemical products, and particularly relates to a composition with a hair care effect and a preparation method thereof.
Background
More than 3 hundred million typical alopecia patients and premature graying hair patients exist in adult people in China. Alopecia and poliosis are pathological phenomena, so that the alopecia and poliosis need to be treated as early as possible, the number of alopecia people is increased at a speed of about 15% per year, and the alopecia people tend to be younger. Alopecia not only seriously affects normal work and life of people, but also seriously destroys the mental health of patients. The hair is an important component of human skin tissues, the hair is generated in the hair follicle, the health condition of the hair follicle directly determines the health condition of the hair, and therefore, the improvement of the nutrition condition and the metabolism condition of the hair follicle is the key for treating alopecia.
Disclosure of Invention
In order to solve the above problems, the first aspect of the present invention provides a composition with hair care effect, comprising the following raw materials by weight: 10-37 parts of ginger extract and 0.1-9 parts of repairing agent;
the repairing agent is at least one of rice fermentation filtrate, millet fermentation filtrate, wheat fermentation filtrate and oat fermentation filtrate.
As a preferable technical scheme of the invention, the preparation method of the rice fermentation filtrate at least comprises the following steps:
1) rice pretreatment: adding amylase into the rice dispersion liquid, heating to 70-90 ℃, and reacting for 15-25 min;
2) activating strains:
activating lactobacillus preserved at 4 deg.C on MRS slant culture medium, culturing at 37 deg.C for 24 hr, selecting slant strain, and culturing at 37 deg.C for 24 hr to obtain lactobacillus seed culture medium; and/or
Activating Bacillus bifidus stored at 4 deg.C on PDA slant culture medium, culturing at 28 deg.C for 48 hr, selecting one ring of the activated strain from the slant culture medium, culturing at 28 deg.C for 24 hr to obtain Bacillus bifidus seed culture medium;
3) fermentation: adding the rice pretreatment liquid obtained in the step 1) into a fermentation tank, inoculating the lactobacillus seed culture medium and/or bifidobacterium seed culture medium obtained in the step 2) according to the concentration of 6-16%, and fermenting at the temperature of 35-39 ℃ for 36-60 h to obtain fermentation liquid;
4) and (3) post-treatment: and 3) centrifuging, filtering and purifying the fermentation liquor obtained in the step 3).
As a preferable technical scheme of the invention, the weight percentage of amylase in the rice dispersion liquid in the rice pretreatment process is 0.05-0.2%.
As a preferable technical scheme, the invention comprises the following raw materials in parts by weight: 15-30 parts of ginger extract and 1.5-6 parts of repairing agent.
According to a preferable technical scheme of the invention, the weight ratio of the ginger extract to the repairing agent is (5-15): 1.
as a preferable technical scheme, the traditional Chinese medicine composition also comprises 60-85 parts of traditional Chinese medicine extract.
As a preferred technical solution of the present invention, the Chinese herbal medicine extract is selected from at least one of an angelica sinensis extract, a rehmanniae radix preparata extract, and a salvia miltiorrhiza extract, and at least one of a black sesame seed extract, a bauhinia variegata extract, and a airpotato yam seed extract.
As a preferred technical scheme of the invention, the traditional Chinese medicine extract is a caulis piperis zibethum extract and an angelica sinensis extract.
As a preferable technical scheme of the invention, the weight ratio of the extract of the glaucescent fissistigma root to the extract of the Chinese angelica in the extract of the traditional Chinese medicines is (1-4): 1.
in a second aspect, the present invention provides a method for preparing a composition having hair care effect, comprising at least the steps of: mixing the raw materials of each component to obtain the product.
Has the advantages that: according to the composition with the hair care effect, the special process and components are adopted, so that the inherent problems that the effect of a hair care product is not ideal and the scalp problem cannot be effectively improved are solved, the absorption of skin tissue nutrient components and the excretion of waste substances can be promoted, the scalp ecology is improved, and the composition contains rich trace elements and is beneficial to hair strengthening and hair growth; in addition, the radix linderae extract also has the effects of nourishing and moistening hair, promoting hair growth, thoroughly improving scalp ecology, accelerating and smoothing blood circulation, ensuring sufficient nutrient substances, completely removing redundant grease, activating blocked hair follicles and ensuring normal hair growth. The composition of the invention nourishes scalp from inside to outside, warmly tonifies kidney, activates hair follicle and achieves the aim of hair care.
Detailed Description
The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, and the scope of protection is not limited thereto. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The words "preferred," "more preferred," "most preferred," and the like in this disclosure mean embodiments of the invention that may, in some instances, provide some benefit. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
In order to solve the above problems, the first aspect of the present invention provides a composition with hair care effect, comprising the following raw materials by weight: 10-37 parts of ginger extract and 0.1-9 parts of repairing agent.
In a preferred embodiment, the feed comprises the following raw materials in parts by weight: 15-30 parts of ginger extract and 1.5-6 parts of repairing agent.
Ginger extract
The ginger extract is extracted from ginger, also called ginger extract and ginger root extract, and the active ingredients include gingerol, zingiberene, bisabolene, α -curcumene (α -curcumene), linalool (linalool), eucalyptol (cineole) and α -borneol, and in addition, the pungent ingredient gingerol and the decomposition product zingerone (gingerone) also contain various amino acids and the like.
The ginger is fresh rhizome of Zingiber ficinalelRosc of Zingiberaceae. Collected in autumn and winter to remove fibrous root and silt. The product is irregular, flat, with finger-shaped branches, 4-18 cm long and 1-3 cm thick. The surface is yellow brown or gray brown, and has links, and the top of the branch has stem marks or buds. Brittle and easy to break, the section is light yellow, the ring veins of the endothelial layer are obvious, and the vascular bundles are scattered. Special smell and spicy taste. Has effects in invigorating stomach, resisting gastric ulcer, promoting function of gallbladder, protecting liver, tonifying heart, inhibiting platelet aggregation, preventing dizziness, resisting tumor, inhibiting central nervous system, enhancing immunity, resisting bacteria, killing parasite, and relieving inflammation, and also has strong antioxidant effect. Can be used as food additive; is used for preparing essence. Referring to Changfa Yangrongsan from Ruihubang Jing Yan Fang, fresh ginger can dispel wind and activate blood, dredge channels and collaterals, accelerate circulation, activate hair follicles, promote absorption of nutrients in skin tissues and excretion of waste substances, and improve scalp ecology.
In a preferred embodiment, the preparation method of ginger extract of the present invention at least comprises the following steps:
(1) peeling rhizoma Zingiberis recens, cutting into pieces, soaking in 0.1-1% saline water for 3-5min, and blanching in 50-100 deg.C water for 1-10 min;
(2) slicing the ginger blocks obtained in the step (1), juicing, filtering by using a 100-mesh and 500-mesh screen, collecting filtrate, adding 0.1-2% of preservative in volume percent into the filtrate, and stirring for 5-10min to obtain mixed solution;
(3) clarifying the mixed solution obtained in the step (2) by using a ZTC1+1 clarifying agent, centrifuging for 5-15min at the rotating speed of 5000-10000rpm, and collecting supernatant to obtain crude ginger juice;
(4) irradiating the crude ginger juice obtained in the step (3) by using a fluorescent lamp for 12-72 hours until the color of the ginger juice is stable and does not fade;
(5) centrifuging the substance obtained in the step (4) at the rotating speed of 6000-.
The preservative described in step (2) in the present invention is not particularly limited, and various preservatives conventionally used in the art may be used, and examples thereof include: benzoic acid, sodium benzoate, hydroxybenzoate and its derivatives, lactic acid, propionic acid, sodium propionate, sorbic acid, potassium sorbate, ascorbic acid, sodium ascorbate, gallic acid, and sodium gallate.
The ZTC1+1 clarifying agent in the step (3) is a natural high molecular substance extracted from food, and consists of two components A and B, wherein a 1+1 clarifying technology is adopted, one component has a main flocculation effect, and the other component has an auxiliary flocculation effect through bridging, so that the clarifying process is accelerated.
In a preferred embodiment, the clarification treatment of step (3) comprises the following steps:
weighing 0.5-2g of component A of ZTC1+1 clarifier, adding water to mix into paste, adding water to 100mL, and swelling for 12-36h to obtain a component A solution;
II, weighing 0.5-2g of component B of the ZTC1+1 clarifying agent, adding 1% acetic acid aqueous solution to mix into paste, adding 1% acetic acid aqueous solution to 100mL, and swelling for 12-36h to obtain component B solution;
III, taking 1000ppm of the component B solution obtained in the step II, and standing for 1-3h, wherein stirring is carried out once every 0.5 h; adding the component A solution obtained in the step I, and standing for 3-5 hours; the volume ratio of the component A solution to the component B solution is 1: (1-10).
The mixing mode in the step I is mechanical stirring, the rotating speed is 100-300rpm, and the time is 2-6 min.
The mixing mode in the step II is mechanical stirring, the rotating speed is 100-300rpm, and the time is 2-6 min.
The 1% acetic acid solution in the step II means that the volume percentage of acetic acid in the acetic acid aqueous solution is 1%.
The invention has no special limitation on the shape and power of the fluorescent lamp in the step (4), as long as the illumination requirement can be met without influencing the purpose of the invention, and the shapes can be listed as follows: the straight pipe type, the annular type and the single-end compact type are adopted; the powers may be listed as: 4W, 6W, 8W, 12W, 15W, 20W, 30W, 36W, 40W, 65W, 80W, 85W and 125W.
In a preferred embodiment, the fluorescent lamp of the present invention is a straight tube type, and has a power of 30W.
Repairing agent
In a preferred embodiment, the repairing agent is at least one selected from rice fermentation filtrate, millet fermentation filtrate, wheat fermentation filtrate and oat fermentation filtrate.
In a more preferred embodiment, the repairing agent of the present invention is rice fermentation filtrate.
Fermented rice filtrate
The Rice (Rice) is a finished product made by the working procedures of Rice cleaning, Rice hulling, Rice milling, finished product arrangement and the like, contains nearly 64 percent of nutrient substances in the Rice and more than 90 percent of nutrient elements required by human bodies, and is a main food for people in most regions of China. The rice contains about 75% of carbohydrate, 7% -8% of protein, 1.3% -1.8% of fat and rich B vitamins. The carbohydrate in the rice is mainly starch, the protein is mainly glutelin, and secondly gliadin and globulin, the biological value of the protein and the composition ratio of amino acid are higher than that of cereal crops such as wheat, barley, millet, corn and the like, the digestibility is 66.8-83.1%, and the carbohydrate is also one of the cereal proteins.
In a preferred embodiment, the preparation method of the rice fermentation filtrate at least comprises the following steps:
1) rice pretreatment: adding amylase into the rice dispersion liquid, heating to 70-90 ℃, and reacting for 15-25 min;
2) activating strains: inoculating lactobacillus preserved at 4 deg.C to MRS slant culture medium, activating, and culturing at 37 deg.C for 24 hr; then, one ring of the slant strain is selected and connected in MRS liquid test tube culture medium, and cultured for 24h at 37 ℃ to be used as lactobacillus seed culture medium; and/or
Activating Bacillus bifidus stored at 4 deg.C on PDA slant culture medium, culturing at 28 deg.C for 48 hr, selecting one ring of the activated strain from the slant culture medium, culturing at 28 deg.C for 24 hr to obtain Bacillus bifidus seed culture medium;
3) fermentation: adding the rice pretreatment liquid obtained in the step 1) into a fermentation tank, inoculating the lactobacillus seed culture medium and/or bifidobacterium seed culture medium obtained in the step 2) according to the concentration of 6-16%, and fermenting at the temperature of 35-39 ℃ for 36-60 h to obtain fermentation liquid;
4) and (3) post-treatment: and 3) centrifuging, filtering and purifying the fermentation liquor obtained in the step 3).
Wherein:
the amylase in the step 1) is at least one selected from high temperature resistant α -amylase, β -amylase, gamma-amylase and isoamylase.
The lactobacillus in the step 2) is selected from one of lactobacillus plantarum, lactobacillus casei, lactobacillus acidophilus, lactobacillus crispatus, lactobacillus formaticus, lactobacillus inerticus and lactobacillus jensenii, and is preferably lactobacillus plantarum;
the Bifidobacterium is selected from one of Bifidobacterium adolescentis, Bifidobacterium infantis, Bifidobacterium apis, Bifidobacterium catenulatum, Bifidobacterium odonis, Bifidobacterium breve, Bifidobacterium longum and Bifidobacterium bifidum, preferably Bifidobacterium longum;
the lactobacillus seed culture medium in the step 3): the quantity ratio of bifidobacterium seed culture medium bacteria is (1-3): 1.
as an embodiment, the lactobacillus seed medium in step 3): the quantity ratio of bifidobacterium seed culture medium bacteria is 1: 1.
as an embodiment, the lactobacillus seed medium in step 3): the number ratio of bifidobacterium seed culture medium bacteria is 3: 1.
as a preferred embodiment, the fermentation temperature is 37 ℃.
The preparation method of the rice dispersion liquid in the step 1) comprises the following steps: adding rice into water with the temperature of 35-45 ℃ for soaking for 3-5h, wherein the weight ratio of the rice to the water is 1: (2-4); grinding for 0.2-1h by using a paste grinder; adding water, and stirring at 400-600rpm for 0.1-0.5h to obtain rice dispersion; in the rice dispersion liquid, the content of rice is 20-30 wt%.
In a preferred embodiment, the weight percentage of amylase in the rice dispersion liquid in the rice pretreatment process in the step 1) is 0.05-0.2%.
In a preferred embodiment, during the fermentation process in the step 3), a pH regulator is also used for regulating the pH value of the system to be 5.5-6.5.
The pH regulator of the present invention is not particularly limited as long as the pH of the system can be controlled without impairing the object of the present invention, and there may be mentioned: citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, citric acid.
In a preferred embodiment, during the fermentation in step 3), the dissolved oxygen is controlled to be 10-20%, and the dissolved oxygen is calibrated to be 100% of the volume of air.
The applicant finds that the lactobacillus and the bifidobacterium are very sensitive to oxygen, and the proportion of the two strains in a mixed system is adjusted by controlling the dissolved oxygen in the fermentation process, so that rice fermentation filtrates with different metabolites, namely the difference of VB vitamin content, are obtained.
In a preferred embodiment, the post-treatment process described in step 4) requires a preliminary solid-liquid separation and microfiltration ultrafiltration separation.
The solid-liquid separation equipment comprises but is not limited to a tubular centrifuge, a plate-frame filter, a vacuum drum filter and the like.
In a preferred embodiment, the post-treatment process in step 4) is: centrifuging the fermentation liquid obtained in the step 3) for 3-10min at the rotating speed of 12000-14000rpm, and taking the supernatant; filtering the supernatant with ultrafiltration membrane with pore diameter of 0.02-0.22 μm to obtain filtrate, i.e. rice fermentation filtrate.
The centrifugation is not particularly limited, and can be one of a tubular centrifuge, a plate and frame filter and a vacuum rotary drum filter;
the organic filter membrane of the present invention is not particularly limited as long as the desired filtrate can be obtained without affecting the object of the present invention, and there may be mentioned: polytetrafluoroethylene filter membrane, polyvinylidene fluoride filter membrane, polypropylene filter membrane, nylon filter membrane.
The filtration is carried out by an ultrafiltration membrane, and the aperture of the ultrafiltration membrane is 0.02-0.22 μm.
The applicant finds that the B vitamins are water-soluble vitamins which are indispensable for maintaining the normal function and metabolic activity of a human body, and the vitamin B2 is involved in vivo biological oxidation and energy metabolism, is related to the metabolism of carbohydrates, proteins, nucleic acids and fats, and has the functions of maintaining the integrity of skin and cell membranes and protecting skin hair follicle mucosa and sebaceous glands; vitamin B5 mainly takes part in sugar, lipid and protein metabolism in the form of coenzyme (CoA) in vivo, and the symptoms of growth stop, weight loss, skin and hair disorders and the like can occur in the absence of vitamin B5; vitamin B6 is essential for fat and sugar metabolism, and vitamin B6 can cause inappetence, anemia, melancholy, headache, hair loss, asthenia, etc.
The B vitamins cannot be produced and synthesized by human bodies and must be additionally supplemented. And the redundant B vitamins can not be stored in the body and can be completely discharged out of the body. Therefore, the B vitamins must be replenished daily. The vitamins of the B group have synergistic effect, namely, the vitamins of the B group are better than the vitamins of the B group which are respectively ingested at one time.
The fermentation product filtrate provided by the invention is rich in a large amount of B vitamins, and can promote scalp repair and formation of hair collagen and keratin.
In a preferred embodiment, the weight ratio of the ginger extract to the repairing agent is (5-15): 1.
in a more preferred embodiment, the weight ratio of the ginger extract to the repairing agent is (7-9): 1.
chinese medicinal extract
In a preferred embodiment, the invention also comprises 60-85 parts of traditional Chinese medicine extract.
In a preferred embodiment, the herbal extract is selected from at least one of angelica extract, rehmanniae radix extract, and salvia extract, and at least one of black sesame extract, bauhinia variegata extract, and airpotato yam extract.
The radix Angelicae sinensis extract is extract of radix Angelicae sinensis (Angelica sinensis (Oliv.) Diels) belonging to Umbelliferae of Umbelliferae.
The Semen Sesami Niger extract is extract of Semen Sesami Niger (Semen Sesaminigrum) of Pedaliaceae of tubular meshes.
The radix Stephaniae Sinicae extract is extract of Polygoni Multiflori radix (Fallopia multiflora (Thunb.) Harald.) belonging to Polygonaceae family.
The flos Lonicerae extract is extract of Lonicera japonica Thunb (Lonicera japonica Thunb.) of Caprifoliaceae of Dipsacales.
The cortex Mori extract is obtained by removing cortex Mori (Morus alba L.) of Moraceae of dicotyledonous plants.
In a preferred embodiment, the Chinese medicinal extracts of the invention are a caulis piperis zibethum extract and an angelica sinensis extract.
In a preferred embodiment, the weight ratio of the bauhinia championii extract to the angelica sinensis extract in the traditional Chinese medicine extract is (1-4): 1.
in a more preferred embodiment, the weight ratio of the sinomenium acutum extract to the angelica sinensis extract in the traditional Chinese medicine extract is (2-3): 1.
radix Stephaniae Sinicae extract
The radix aconiti kusnezoffii extract is extracted from radix aconiti kusnezoffii, also called as polygonum multiflorum extract and polygonum multiflorum root extract, and the effective components of the radix aconiti kusnezoffii extract comprise: the root tuber contains anthraquinone compounds, mainly emodin, chrysophanol, physcion, rhein, chrysophanol anthrone.
The bauhinia (known as Fallopsiflora (Thunb.) Harald), also called Polygonum multiflorum, Polygonum multiflorum and Tuber fleeceflower stem, which are perennial plants, root tuber hypertrophy, oblong shape, blackish brown stem winding, 2-4 m long, multi-branch, with longitudinal arris, hairless, micro-roughness and lower lignification, the tuber root contains anthraquinone compounds (mainly emodin), chrysophanol (chrysophanol) and physcion (physcion), rhein (rhein), chrysophanol anthrone (chrysophanol) and stilbene compounds (resveratrol), piceatannoside (piceatannode), 2,3,5,4 ' -Tetrahydroxystilbene-2-O-D-glucoside (2,3,5,4 ' -Tetrahydroxystilbene-2-O-D-glucoside), 3-3, 3 ' -Tetrahydroxystilbene-2-O-D-glucoside (3, 3-3, 3 ' -tetrahydroxystilben-2-O-3 ' -galloyl-3, 3-3 ' -galloyl-3 ' -galloyl (-) -epigallocatechin, 3-3 ' -gallate, (-) - (-) -epigallocatechin), 3, 3-3 ' -epigallocatechin, 3 ' -gallate, 3 ' -epigallocatechin, 3 ' -gallate, 3 ' -epigallocatechin, 3 ' -gallate and 3 ' -gallate (3 ' -gallate, 3 ' -gallate and 3 ' -gallate, 3 ' -epigallocatechin, 3 ' -gallate of the like, 3 ' -epigallocatechin.
Chinese angelica extract
The angelica extract is extracted from angelica, and the active ingredients of the angelica extract comprise: ligustilide (ligusilide), n-butyrylenephthalide (n-butyrilepthhalide), ferulic acid, nicotinic acid, sucrose, various amino acids, and sesquiterpene compounds.
The Chinese Angelica (known as Angelica sinensis (Oliv.) Diels) is also called dry Angelica, Qinlian, West Angelica, Min Angelica, golden Angelica, Angelica sinensis, radix Angelicae sinensis, radix Stephaniae Sinicae, radix Angelicae sinensis and radix Angelicae sinensis. Perennial herbs with a height of 0.4-1 meter. The root is cylindrical and branched, has a plurality of fleshy fibrous roots, is yellowish brown and has strong fragrance. Upright stem, greenish white or purple with deep furrows, smooth and hairless. Enriching the blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestine. The main symptoms are blood deficiency; menoxenia; amenorrhea; dysmenorrhea; the accumulation of symptoms; (ii) metrorrhagia and metrostaxis; abdominal pain due to deficiency-cold; flaccidity and paralysis; numbness of the skin; intestinal dryness and difficult defecation; severe dysentery with diarrhea; carbuncle, cellulitis, sore and ulcer; injury from falling.
The ginger extract contains active ingredients such as gingerol, zingiberene, bisabolene, α -curcumene, linalool, eucalyptol, various amino acids and the like, has the effects of dispelling wind and activating blood, smoothing meridians, accelerating circulation, activating hair follicles and the like, can promote absorption of skin tissue nutrient ingredients and excretion of waste substances, and improves scalp ecology, the angelica extract contains active ingredients such as ligustilide, n-butenoyl lactone, ferulic acid, sucrose, various amino acids and the like, has the effects of tonifying qi and producing blood, regulating menstruation and activating blood, can expand scalp capillaries, promote blood circulation, contains rich trace elements, is favorable for fixing hair and growing hair, and when the repairing agent is rice fermentation filtrate, can promote scalp repair and formation of hair collagen and keratin due to the fact that the repairing agent is rich in B vitamins, wherein VB3 cell energy metabolism main coenzymes can be converted into nicotinic acid, stimulate and improve blood microcirculation, are cell energy factors, are novel hair activating elements, VB6 normalizes protein and amino acid metabolism of head skin, effectively regulates sebaceous glands of head, can be used as an anti-lipid-seborrheic dermatitis treating seborrheic dermatitis.
In a second aspect, the present invention provides a method for preparing a composition having hair care effect, comprising at least the steps of: mixing the raw materials of each component to obtain the product.
As a preferred embodiment, the method for preparing the composition with hair care effect at least comprises the following steps: mixing the raw materials at 40-60 deg.C.
The mixing process of the invention is as follows: mixing rhizoma Zingiberis recens extract, repairing agent and Chinese medicinal extract for 0.5-3 hr.
The mixing method of the present invention is not particularly limited as long as the raw materials of the components can be uniformly mixed without affecting the object of the present invention, and there may be exemplified: mechanical stirring, ultrasonic dispersion and oscillation.
In a preferred embodiment, the mixing method of the present invention is mechanical stirring, and the rotation speed is 400-800 rpm.
The present invention will now be described in detail by way of examples, and the starting materials used are commercially available unless otherwise specified.
Examples
Rice fermentation filtrate preparation example 1
The preparation method of the rice fermentation filtrate comprises the following steps:
1) rice pretreatment, namely adding high-temperature resistant α -amylase into rice dispersion liquid, heating to 80 ℃, and reacting for 20 min;
2) activating strains: activating lactobacillus plantarum preserved at 4 ℃, culturing at 37 ℃ for 24h, selecting a slant strain, and connecting the slant strain to an MRS liquid test tube culture medium in a loop manner, and culturing at 37 ℃ for 24h to serve as a lactobacillus seed culture medium;
activating Bifidobacterium longum stored at 4 deg.C on PDA slant culture medium, culturing at 28 deg.C for 48 hr, selecting one loop of the activated strain from the slant culture medium, culturing at 28 deg.C for 24 hr to obtain Bifidobacterium longum seed culture medium;
3) fermentation: adding the rice pretreatment liquid obtained in the step 1) into a fermentation tank, inoculating the lactobacillus plantarum seed culture medium and the bifidobacterium longum seed culture medium obtained in the step 2) according to the concentration of 10% (the number ratio of the lactobacillus plantarum seed culture medium to the bifidobacterium longum seed culture medium is 3: 1) fermenting at 37 deg.C for 48h to obtain fermentation liquid;
4) and (3) post-treatment: and 3) centrifuging, filtering and purifying the fermentation liquor obtained in the step 3).
The preparation method of the rice dispersion liquid in the step 1) comprises the following steps: adding rice into water of 40 ℃ for soaking for 4h, wherein the weight ratio of the rice to the water is 1: 3; grinding for 0.5h by using a paste grinder; adding water, and stirring at 500rpm for 0.3 hr to obtain rice dispersion; the content of rice in the rice dispersion liquid is 25 wt%.
The weight percentage of the high-temperature resistant α -amylase in the rice dispersion liquid in the rice pretreatment process in the step 1) is 0.1%.
And 3) in the fermentation process, a pH regulator is also adopted to regulate the pH value of the system to be 6.0.
The pH regulator is citric acid.
And 3) in the fermentation process, controlling the dissolved oxygen to be 15%, wherein the dissolved oxygen is calibrated by taking the volume of air as 100%.
The post-treatment process in the step 4) comprises the following steps: centrifuging the fermentation liquor obtained in the step 3) for 5min at the rotating speed of 13000rpm, and taking supernatant; and filtering the supernatant by using an ultrafiltration membrane with the pore diameter of 0.22 mu m to obtain filtrate, namely the rice fermentation filtrate.
Preparation example 2 of fermented Rice filtrate
The preparation method of the rice fermentation filtrate comprises the specific steps of preparation example 1, and is different from the following steps of 3) fermentation: adding the rice pretreatment liquid obtained in the step 1) into a fermentation tank, inoculating the lactobacillus plantarum seed culture medium obtained in the step 2) according to the concentration of 10%, and fermenting at 37 ℃ for 48 hours to obtain fermentation liquid.
Rice fermentation filtrate preparation example 3
The preparation method of the rice fermentation filtrate comprises the specific steps of preparation example 1, and is different from the following steps of 3) fermentation: adding the rice pretreatment liquid obtained in the step 1) into a fermentation tank, inoculating the lactobacillus plantarum seed culture medium and the bifidobacterium longum seed culture medium obtained in the step 2) according to the concentration of 10% (the number ratio of the lactobacillus plantarum seed culture medium to the bifidobacterium longum seed culture medium is 1: 1) and the fermentation temperature is 37 ℃, and the fermentation time is 48 hours, so as to obtain the fermentation liquor.
Rice fermentation filtrate preparation example 4
The preparation method of the rice fermentation filtrate comprises the specific steps of preparation example 1, and is different from the following steps of 3) fermentation: adding the rice pretreatment liquid obtained in the step 1) into a fermentation tank, inoculating the bifidobacterium longum seed culture medium obtained in the step 2) according to the concentration of 10%, and fermenting at the temperature of 37 ℃ for 48 hours to obtain fermentation liquid.
Example 1
Example 1 provides a composition having hair care efficacy, comprising the following raw materials in parts by weight: 22 parts of ginger extract, 3 parts of repairing agent and 75 parts of traditional Chinese medicine extract.
The Chinese medicinal extract is caulis piperis zibethum extract and radix Angelicae sinensis extract.
The weight ratio of the radix aconiti kusnezoffii extract to the angelica sinensis extract is 2.4: 1.
the preparation method of the ginger extract comprises the following steps:
(1) peeling rhizoma Zingiberis recens, cutting into pieces, soaking in 0.5% saline water for 4min, and blanching in 80 deg.C water for 6 min;
(2) slicing the ginger blocks obtained in the step (1), juicing, filtering by using a 300-mesh screen, collecting filtrate, adding 1% of preservative in volume percentage into the filtrate, and stirring for 8min to obtain mixed liquor;
(3) clarifying the mixed liquor obtained in the step (2) by using a ZTC1+1 clarifying agent, centrifuging for 10min at the rotating speed of 7000rpm, and collecting supernatant to obtain crude ginger juice;
(4) irradiating the crude ginger juice obtained in the step (3) by using a fluorescent lamp for 48 hours until the color of the ginger juice is stable and does not fade;
(5) and (4) centrifuging the substance obtained in the step (4) at the rotating speed of 7000rpm for 7min, collecting supernatant, filtering by using a microporous filter membrane with the aperture of 300nm, and collecting permeate.
The preservative in the step (2) is sodium benzoate.
The clarification treatment of the step (3) comprises the following steps:
weighing 1g of component A of a ZTC1+1 clarifying agent, adding water to mix into paste, adding water to 100mL, and swelling for 24h to obtain a component A solution;
II, weighing 1g of component B of the ZTC1+1 clarifying agent, adding 1% acetic acid aqueous solution to mix into paste, adding 1% acetic acid aqueous solution to 100mL, and swelling for 24h to obtain a component B solution;
III, taking 500ppm of the component B solution obtained in the step II, and standing for 2 hours, wherein stirring is carried out once every 0.5 hour; adding the component A solution obtained in the step I, and standing for 4 hours; the volume ratio of the component A solution to the component B solution is 1: 5.
the mixing mode in the step I is mechanical stirring, the rotating speed is 200rpm, and the time is 4 min.
And the mixing mode in the step II is mechanical stirring, the rotating speed is 200rpm, and the time is 4 min.
The 1% acetic acid solution in the step II means that the volume percentage of acetic acid in the acetic acid aqueous solution is 1%.
The fluorescent lamp in the step (4) is of a straight tube type, and the power is 30W.
The repairing agent is rice fermentation filtrate prepared in preparation example 1.
Example 1 also provides a method for preparing a composition having hair care effects, comprising the steps of: mixing the raw materials at 50 deg.C.
The mixing process comprises the following steps: mixing rhizoma Zingiberis recens extract, repairing agent and Chinese medicinal extract for 1 hr.
The mixing mode is mechanical stirring, and the rotating speed is 600 rpm.
Example 2
Embodiment 2 provides a composition with hair care effect, which comprises the following raw materials in parts by weight: 15 parts of ginger extract, 1.5 parts of repairing agent and 60 parts of traditional Chinese medicine extract.
The raw materials of the components are the same as those in example 1.
Example 2 also provides a method for preparing a composition having hair care effects, comprising the steps of: mixing the raw materials at 40 deg.C.
The mixing process comprises the following steps: mixing rhizoma Zingiberis recens extract, repairing agent and Chinese medicinal extract for 0.5 h.
The mixing mode is mechanical stirring, and the rotating speed is 400 rpm.
Example 3
Example 3 provides a composition with hair care efficacy, comprising the following raw materials in parts by weight: 30 parts of ginger extract, 6 parts of repairing agent and 85 parts of traditional Chinese medicine extract.
The raw materials of the components are the same as those in example 1.
Example 3 also provides a method for preparing a composition having hair care effects, comprising the steps of: mixing the raw materials at 60 deg.C.
The mixing process comprises the following steps: mixing rhizoma Zingiberis recens extract, repairing agent and Chinese medicinal extract for 3 hr.
The mixing mode is mechanical stirring, and the rotating speed is 800 rpm.
Comparative example 1
Comparative example 1The specific implementation mode of the composition with the hair care effect is the same as that of example 1, except that the weight part of the ginger extract is replaced by 50 parts。
Comparative example 2
Comparative example 2The specific implementation mode of the composition with the hair care effect is the same as that of example 1, except that the weight part of the ginger extract is replaced by 5 parts.
Comparative example 3
Comparative example 3The specific implementation mode of the composition with the hair care effect is the same as that of example 1, except that the weight percentage of the high-temperature resistant α -amylase in the rice dispersion liquid is replaced by 0.01%.
Comparative example 4
Comparative example 4The specific implementation mode of the composition with the hair care effect is the same as that of example 1, except that the weight percentage of the high-temperature resistant α -amylase in the rice dispersion liquid is replaced by 0.5%.
Comparative example 5
Comparative example 5A composition having hair care effects and a method for preparing the same are provided, and the specific embodiment is the same as example 1, except that the temperature during the rice pretreatment process is changed to 50 ℃.
Comparative example 6
Comparative example 6A composition having hair care effects and a method for preparing the same are provided, and the specific embodiment is the same as example 1, except that the temperature during the rice pretreatment process is changed to 150 ℃.
Example 4
Example 4The specific implementation mode of the composition with the hair care effect is the same as that in example 1, except that the repairing agent is rice fermented filtrate prepared in rice fermented filtrate preparation example 2.
Example 5
Example 5The specific implementation mode of the composition with the hair care effect is the same as that of example 1, except that the repairing agent is rice fermentation filtrate preparation example 3Preparing rice fermentation filtrate.
Example 6
Example 6The specific implementation mode of the composition with the hair care effect is the same as that in example 1, except that the repairing agent is rice fermented filtrate prepared in rice fermented filtrate preparation example 4.
Component detection
By HPLC-MS/MSFor those obtained in preparation examples 1 to 4And (4) detecting the content of VB2, VB5 and VB6 in the rice fermentation filtrate.
The HPLC-MS/MS analysis conditions are as follows:
a chromatographic column: waters ACQUITY UPLC HSS T3(2.1 mm. times.100 mm, 1.8 μm); mobile phase: 10mmol/L aqueous ammonium formate solution (pH 5) (phase a) and 0.1% formic acid-methanol solution (phase B); flow rate: 0.3 mL/min; column temperature: 40 ℃; sample introduction amount: 1 μ L.
Elution gradient:
the phase B is increased from 0% to 10.00% in 0-2.5 min;
2.5-5.0 min, phase B rises to 10.50%;
5.0-7.0 min, phase B rising to 10.90%;
7.0-7.1 min, rising phase B to 30.33%;
7.1-10.1 min, rising phase B to 30.50%;
10.1-15.0 min, phase B rising to 45.00%;
15.0-15.1 min, phase B rising to 100.00%;
15.1-18.0 min, keeping phase B at 100.00%.
An ionization mode: electrospray ionization source, positive ionization mode; capillary voltage: 4 kV; atomizing gas pressure: 275.79kPa (40 psi); flow rate of drying gas: 12L/min; temperature of the drying gas: 290 ℃; the flow rate of the sheath gas: 11L/min; temperature of sheath gas: 200 ℃; the detection mode is as follows: multiple Reaction Monitoring (MRM) mode.
Sample processing
5mL of rice fermentation filtrate is taken, and 40mL of 0.1mol/L hydrochloric acid is added for even ultrasonic mixing. Then adding 0.1mol/L hydrochloric acid to a constant volume of 50mL, ultrasonically mixing uniformly, standing, centrifuging, taking supernatant to obtain VB2, VB5 and VB6 extracting solutions, filtering the extracting solutions through a 0.45-micron filter membrane, and then loading on a machine for determination.
Safety test
33 experimenters (10 men and 23 women) were randomly selected, had no history of allergic dermatitis, and had no irritant product within one month, meeting the volunteer enrollment criteria of the subjects.
An enclosed spot-sticking experimental method is adopted, water is used as a control group, about 0.020-0.025 mL of an embodiment is taken, the water is coated in a spot-tester chamber produced by Beijing science popularization instrument factory, a spot-tester is pasted on the back of a subject by using an externally-used special adhesive tape, the spot-tester is removed after being pasted for 48 hours, the residual liquid on the back is slightly wiped by a wet paper towel, the experimental result is recorded according to the skin reaction grading standard stated in the technical Specification for cosmetic safety (2015), and the skin reaction grading standard is shown in the following table.
The skin adverse reaction grading criteria are shown in the following table:
safety test results
Alopecia prevention test
Selecting 12 volunteers with hair loss more than 100/day, using the product by the subject 1 time per day, combing hair 2 times in the morning and evening, collecting and counting fallen hair, and finally averaging and averaging.
Hair Strength Change test
The hair tension of 12 alopecia patients was measured by HVC-SX push-pull force meter to measure the effect of the product on the hair strength by using the tension change before and after the product. Each group of hair samples was tested 3 times and the hair intensity was averaged 3 times.
The hair thinning and softening is essentially the weakening of the hair follicle's ability to synthesize hair, while the lack of hair is the loss of hair synthesizing ability of the follicle, and the result is the same thing, namely the weakening of the hair follicle's ability to grow. Hair strength was evaluated by a tension test, reflecting the viability of the hair follicles. The experimental result shows that the composition can nourish the scalp externally, warm and tonify the kidney, activate hair follicles and improve the hair growth capacity of the hair follicles.
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. The composition with the hair care effect is characterized by comprising the following raw materials in parts by weight: 10-37 parts of ginger extract and 0.1-9 parts of repairing agent;
the repairing agent is at least one of rice fermentation filtrate, millet fermentation filtrate, wheat fermentation filtrate and oat fermentation filtrate.
2. The hair care composition according to claim 1, wherein the rice fermentation filtrate is prepared by a method comprising at least the steps of:
1) rice pretreatment: adding amylase into the rice dispersion liquid, heating to 70-90 ℃, and reacting for 15-25 min;
2) activating strains: activating lactobacillus preserved at 4 deg.C on MRS slant culture medium, culturing at 37 deg.C for 24 hr, selecting slant strain, and culturing at 37 deg.C for 24 hr to obtain lactobacillus seed culture medium; and/or
Activating Bacillus bifidus stored at 4 deg.C on PDA slant culture medium, culturing at 28 deg.C for 48 hr, selecting one ring of the activated strain from the slant culture medium, culturing at 28 deg.C for 24 hr to obtain Bacillus bifidus seed culture medium;
3) fermentation: adding the rice pretreatment liquid obtained in the step 1) into a fermentation tank, inoculating the lactobacillus seed culture medium and/or bifidobacterium seed culture medium obtained in the step 2) according to the concentration of 6-16%, and fermenting at the temperature of 35-39 ℃ for 36-60 h to obtain fermentation liquid;
4) and (3) post-treatment: and 3) centrifuging, filtering and purifying the fermentation liquor obtained in the step 3).
3. The composition with hair care effect according to claim 2, wherein the amylase accounts for 0.05-0.2% of the weight of the rice dispersion liquid in the rice pretreatment process.
4. The composition with hair care effect according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 15-30 parts of ginger extract and 1.5-6 parts of repairing agent.
5. The composition with hair care effect according to claim 1 or 4, wherein the weight ratio of the ginger extract to the repairing agent is (5-15): 1.
6. the composition with hair care effect according to claim 1, which is characterized by further comprising 60-85 parts of traditional Chinese medicine extract.
7. The composition with hair care effect according to claim 6, wherein the herbal extract is at least one selected from the group consisting of an angelica extract, a rehmanniae radix preparata extract, and a salvia miltiorrhiza extract, and at least one selected from the group consisting of a black sesame extract, a bauhinia championii extract, and a airpotato yam extract.
8. The composition with hair care effect according to claim 7, wherein the traditional Chinese medicine extract is a caulis piperis zibethum extract and an angelica sinensis extract.
9. The composition with hair care effect according to claim 8, wherein the weight ratio of the glaucescent fissistigma root extract to the angelica sinensis extract in the traditional Chinese medicine extract is (1-4): 1.
10. a method for preparing a hair care composition according to any one of claims 1 to 9, comprising at least the following steps: mixing the raw materials of each component to obtain the product.
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| CN112442466A (en) * | 2020-12-11 | 2021-03-05 | 桂林长发小寨生物科技有限公司 | Rice washing water fermentation product with scalp aging resisting function and preparation method thereof |
| CN112522150A (en) * | 2020-12-11 | 2021-03-19 | 桂林长发小寨生物科技有限公司 | Rice washing water plant fermentation product capable of long-acting removing dandruff and relieving itching and preparation method thereof |
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| CN112535656A (en) * | 2020-12-11 | 2021-03-23 | 桂林长发小寨生物科技有限公司 | Probiotic plant fermentation product with hair blacking function and preparation method |
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| CN112538444A (en) * | 2020-12-11 | 2021-03-23 | 桂林长发小寨生物科技有限公司 | Rice washing water fermentation product with scalp oil control and hair softening double-effect functions |
| CN112535656A (en) * | 2020-12-11 | 2021-03-23 | 桂林长发小寨生物科技有限公司 | Probiotic plant fermentation product with hair blacking function and preparation method |
| CN112442466B (en) * | 2020-12-11 | 2021-08-03 | 桂林长发小寨生物科技有限公司 | Rice washing water fermentation product with scalp aging resisting function and preparation method thereof |
| CN112538444B (en) * | 2020-12-11 | 2021-08-03 | 桂林长发小寨生物科技有限公司 | Rice washing water fermentation product with scalp oil control and hair softening double-effect functions |
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