CN105434256A - Natural emulsion, and preparation method and applications thereof - Google Patents
Natural emulsion, and preparation method and applications thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention provides a natural emulsion, and a preparation method and applications thereof. The natural emulsion comprises, by weight, 5 to 10 parts of myrtle lactobacillus fementation extract, 0.3 to 1.0 part of spiraea thunbergii leaf extract, 2 to 7 parts of asparagus extract, 0.2 to 1.0 part of swertia bimaculata extract, 0.3 to 1.0 part of a natural large molecular polymer thickening agent, 10 to 15 parts of a polyhydric alcohol, and 0.05 to 0.3 part of a natural plant preservative. The natural emulsion is capable of removing free radicals, inhibiting activity of tyrosinase, promoting proliferation of skin keratinocyte, and reducing release of histamine at the same time; it is shown by cell experiments that the natural emulsion possesses no cytotoxicity, and safety is high; and the natural emulsion possesses a promising market prospect in the fields of development of skin care products used for whitening and repairing skin.
Description
Technical field
The invention belongs to cosmetic material preparing technical field, particularly a kind of preparation of natural emulsion and the application in maintenance, whitening, the skin care item such as crease-resistant thereof.
Background technology
Present stage, fair complexion is the best skin condition that Aisan is pursued always, and people with the addition of the product with white-skinned face function composition often through use, and to obtaining good whitening effect, therefore whitening product has very large demand space.The statistical reports display of Min Te company, the first half of the year in 2013, for the women Internet user using face protection product in 1493 20-49 years in the past 6 months, user product being expected to have to whitening effect accounts for 61%, can find out that the demand of whitening product is larger.But the untoward reaction that cosmetics cause has the trend of showed increased, hair dye is irritated, freckle removing and whitening product has report when containing the problems such as unauthorized substances, and safety remains the problem of cosmetic industry and consumer's extensive concern.The precious whitening product of the Japan beauty second half year in 2012 causes white macula event duration so far, and victim's number is still in increase.Whitening complexion changed is talked instantly, the problem of overriding concern when the safety of whitening product becomes Related product exploitation in industry many people.In December, 2013, whitening product, for ensureing consumer health's rights and interests, is included in caused by cosmetics for special use management by state food pharmaceuticals administration general bureau, thus the better security risk controlling skin-lightening cosmetic.When therefore developing whitening product, add there is white-skinned face function raw material be selected to an of paramount importance link, make whitening composition while guarantee whitening effect, safety is the content of first concern, therefore, the whitening raw material of high security is a trend of Related product exploitation.
At present, environmental pollution is serious, skin of face is exposed in large quantity of air pollutant, such as vehicle exhaust, ionizing radiation, oxygen-derived free radicals, ultraviolet, koniology etc., these pollutant produce a large amount of free radical, easily cause skin over oxidation, cause and stimulate and excessive skin injury, even cause dermatosis.Therefore, repairing environment pollutes the important need that the skin excessive damage caused is this series products of exploitation.
Summary of the invention
The object of the present invention is to provide a kind of natural emulsion, preparation method and application thereof.Natural emulsion of the present invention can scavenging free radicals, and restraint of tyrosinase is active, promotes the effects such as the propagation of skin keratinocytes, and cell experiment display simultaneously, do not have cytotoxicity, safety is higher.In the skin care item exploitation of whitening, maintenance effect, there is good market prospect.
Technical scheme of the present invention is: a kind of natural emulsion, comprises the component of following weight portion: Fructus Rhodomyrti lactic acid bacteria fermentation extract 5-10 part, Spiraea thunbergii leaf extract 0.3-1.0 part, Germinatus Phragmitis extract 2-7 part, Herba Swertiae bimaculatae extract 0.2-1.0 part, natural macromolecular polymer viscosifier 0.3-1.0 part, polyhydric alcohol 10-15 part and natural plant preservative 0.05-0.3 part.
Described Fructus Rhodomyrti lactic acid bacteria fermentation extract is, after the juice removed the peel by myrtle fruit adopts lactobacillus 48h fermentation, after the fermentation liquid 4000r/min obtained is centrifugal, get supernatant, adopt the liquid that 0.22 micron membrane filter filtration sterilization obtains;
Described Spiraea thunbergii leaf extract is by Spiraea thunbergii leaf, adopts the extracting solution after 95% alcohol heating reflux obtained after concentrated, drying;
Described Germinatus Phragmitis extract is with asparagus spear, after the alcohol extraction of 70%, and concentrated solution obtained after concentrated;
Described Herba Swertiae bimaculatae extract is that Herba Swertiae bimaculatae herb adopts ethyl acetate room temperature, and the extracting solution after dipping obtains after concentrated, drying;
Said extracted method is this area conventional extraction techniques.
Described natural macromolecular polymer viscosifier is one or more in alginate jelly, Flos Robiniae Pseudoacaciae glue, Semen Lini glue, Abelmoschus manihot （L.） Medic glue.
Described polyhydric alcohol be glycerol, butanediol, pentanediol, hexanediol one or more.
Described natural plant preservative be Chinese prickly ash fruit extract, oil of rosemary one or both.
Above-mentioned each component is commercially available prod except specified otherwise.
The preparation method of the natural emulsion of the present invention, comprises the following steps:
S1: take each component according to weight proportion;
S2: by the natural macromolecular polymer viscosifier deionized water dissolving taken, heating, forms liquid one;
S3: the Fructus Rhodomyrti lactic acid bacteria fermentation extract taken, Spiraea thunbergii leaf extract, Germinatus Phragmitis extract, Herba Swertiae bimaculatae extract, polyhydric alcohol are uniformly mixed, obtain thick liquid two;
S4: slowly joined by liquid two in liquid one, stirs, obtains emulsion liquid;
S5: the natural plant preservative taken being added to temperature is in the emulsion liquid of 40 DEG C, is natural emulsion.
Preferably, the temperature in described step S2 is 50-75 DEG C.
Preferably, the mixing time in described step S4 is 20-40min.
The present invention also provides the application of described natural emulsion in preparation maintenance, whitening, crease-resistant skin care item.
The effect of each component in the present invention:
Fructus Rhodomyrti is the evergreen shrubs of Myrtaceae Myrtus, is distributed widely in China southeast, and be a kind of common Chinese herbal medicine, Herb can hyoscine.Among the people, a kind of tonic of its fruit Chang Zuowei carrys out enhancing immunity, and has extremely strong antioxidant activity.Its antioxidant activity is owing to wherein containing more polyphenol substance.Find under study for action, the polyphenol content in Fructus Rhodomyrti is far away higher than other fruit and corn.Polyphenolic substance mainly comprise flavonoid, phenolic acid, quinine, tannin and other.The report in past points out there is stronger dependency between polyphenol content and oxidation resistance.General flavone content in Fructus Rhodomyrti is 49.7mgCE/100g, is also the reason that Fructus Rhodomyrti has high anti-oxidation ability.(simultaneously, containing a certain amount of polysaccharide, pectic substance and fat in Fructus Rhodomyrti fruit,) by the metabolic activity of lactobacillus, experience reaches the process of the several weeks of slowly fermentation in the environment of anaerobic, the enzyme become skin to like with sugar transition the carbohydrate in Fructus Rhodomyrti fruit and aminoacid, effective ingredient is decomposed and macro, and noxious bacteria and toxin are removed naturally, not only natural but also safety.Meanwhile, fermentation makes effective ingredient become easier absorbed micromolecule, improves effect of Fructus Rhodomyrti extract, makes this extract permeability better, has stronger to moisten, repair and anti-oxidation function.
Spiraea thunbergii has another name called basilima sorbifolia, belong to Rosaceae, research shows that the inhibitory action of the ethanol extraction of its fresh leaf to tryrosinase exceedes the inhibitory action that concentration is the arbutin of 1mmol/L, and relative to arbutin, this extract natural origin, has more safety.
Germinatus Phragmitis is rich in several amino acids, protein and vitamin, and its content all higher than the agedoite in general fruit and vegetables, particularly Germinatus Phragmitis and trace element-selenium, molybdenum, chromium, manganese etc., has adjustment organism metabolism, improves effect of body immunity; Flavone compound and polysaccharide are active skull cap components main in Germinatus Phragmitis stem and leaf, have the effect such as antioxidation, reparation.
Herba Swertiae bimaculatae is that in Gentianaceae belongs to greatly, swertiamarin is one of main component in Gentianaceae Swertia plant, and the expansible blood capillary of swertiamarin activates and promote the enzyme system of Skin Cell, improve the biochemical function of skin, can also hair growth disease and for beautifying skin agent.Therefore, Herba Swertiae bimaculatae extract, except the action effect to skin excellence, can also promote the osmotic absorption of other functional components.
Beneficial effect of the present invention:
(1) provide a kind of natural emulsion, it can scavenging free radicals, and restraint of tyrosinase is active, promotes that the propagation of skin keratinocytes reduces the effects such as the release of histamine simultaneously.
(2) this natural emulsion, all the components all belongs to natural origin, extracted form natural plant, and safety is high, and absorbability is good, Be very effective.In use, not only effectively but also safety, zest was little.
Accompanying drawing explanation
Fig. 1 be the natural emulsion of variable concentrations to the rejection ability of tryrosinase (with V
c100mg/mL concentrations versus).
Fig. 2 is the impact (with 1mg/mlEGF compare) of the natural emulsion of variable concentrations on human keratinized cell.
Detailed description of the invention
In order to understand the present invention better, illustrate content of the present invention further below in conjunction with embodiment, but content of the present invention is not only confined to the following examples, embodiment should not regard as limiting the scope of the present invention.
Described in following embodiment, natural constituents extract is: Fructus Rhodomyrti lactic acid bacteria fermentation extract is after the juice removed the peel by myrtle fruit adopts lactobacillus 48h fermentation, after the fermentation liquid 4000r/min obtained is centrifugal, get supernatant, adopt the liquid that 0.22 micron membrane filter filtration sterilization obtains;
Spiraea thunbergii leaf extract is by Spiraea thunbergii leaf, adopts the extracting solution after 95% alcohol heating reflux obtained after concentrated, drying;
Germinatus Phragmitis extract is with asparagus spear, after the alcohol extraction of 70%, and concentrated solution obtained after concentrated;
Herba Swertiae bimaculatae extract is that Herba Swertiae bimaculatae herb adopts ethyl acetate room temperature, and the extracting solution after dipping obtains after concentrated, drying.
Embodiment 1:
In a container, get 0.4g alginate jelly and be dissolved in 20g deionized water, be heated to the liquid one that 65 DEG C obtain thickness; Get another container, add 5.5g Fructus Rhodomyrti lactobacillus extract, 2.5g Spiraea thunbergii leaf extract, the Germinatus Phragmitis extract of 3.0g, the river deer tooth grass extract mixing of 1.5g, then add 15g butanediol and 2g pentanediol, dissolve, add deionized water 49.9g, mixing obtains liquid two; Liquid two is joined in liquid one, lower the temperature after stirring 30min, when temperature is reduced to 40 DEG C, adds the Chinese prickly ash fruit extract of 0.2g, stir, obtain emulsion, be the natural emulsion with whitening, repairing effect.
The natural emulsion of above-mentioned preparation, for having in the skin care item of whitening and reparation, it is as shown in the table that formula frost is repaired in the whitening containing this natural emulsion:
Embodiment 2:
In a container, get 0.3g Flos Robiniae Pseudoacaciae glue and 0.1g Abelmoschus manihot （L.） Medic peptization in 30g deionized water, be heated to the liquid one that 60 DEG C obtain thickness; Get another container, add 7.5g Fructus Rhodomyrti lactic acid bacteria fermentation extract, 3.0g Spiraea thunbergii leaf extract, the Germinatus Phragmitis extract of 4.0g, mix after the Herba Swertiae bimaculatae extract of 1.0g, then add 10g glycerol, 6g butanediol and 2g hexanediol, dissolve, add deionized water 35.95g, mixing obtains liquid two; Liquid two is joined in liquid one, lower the temperature after stirring 25min, when temperature is reduced to 40 DEG C, adds Chinese prickly ash fruit extract and the 0.05g oil of rosemary of 0.1g, stir, obtain emulsion, be the natural emulsion with whitening, repairing effect.
The natural emulsion of above-mentioned preparation is for having in the skin care item of whitening and reparation, and the whitening repair latex formula containing this natural emulsion is as shown in the table:
Embodiment 3:
In a container, get 0.5g Semen Lini glue, 0.2g Flos Robiniae Pseudoacaciae peptization in 25g deionized water, be heated to the liquid one that 60 DEG C obtain thickness; Get another container, add 6.0g Fructus Rhodomyrti lactic acid bacteria fermentation extract, 4.0g Spiraea thunbergii leaf extract, the Germinatus Phragmitis extract of 5.0g, mix after the Herba Swertiae bimaculatae extract of 2.0g, then add, 10g butanediol, 2g pentanediol and 3g hexanediol, dissolve, add deionized water 42.1g, mixing obtains liquid two; Liquid two is joined in liquid one, lower the temperature after stirring 25min, when temperature is reduced to 40 DEG C, adds Chinese prickly ash fruit extract and the 0.12g oil of rosemary of 0.08g, stir, obtain emulsion, be the natural emulsion with whitening, repairing effect.
The natural emulsion of above-mentioned preparation is for having in the skin care item of whitening and reparation, and it is as shown in the table that essence formula is repaired in the whitening containing this natural emulsion:
Test example 1, natural emulsion are on the impact of tryrosinase
Research shows, restraint of tyrosinase, can the synthesis of check melanin, thus reduces melanic generation in skin.This experiment discussion the present invention natural emulsion is to the inhibitory action of tryrosinase.
Preparatory work of experiment:
1, laboratory sample: the natural emulsion of vitamin C (100mg/mL), variable concentrations (5,10,30,50,70,100mg/mL)
2, reagent and instrument: tryrosinase, L--tyrosine, sodium hydrogen phosphate, sodium dihydrogen phosphate thermostat, ultraviolet spectrophotometer, centrifuge.
3, experimental procedure
Experimental group: with pipet add in EP pipe successively respectively 600 μ lPBS buffer, 200 μ l tyrosine, 200 μ l variable concentrations natural emulsion (each concentration is 5,10,30,50,70,100mg/ml), 200 μ l tryrosinases, 6 EP pipes are put into 30 DEG C of water-baths and keep temperature-resistant 30min.
Matched group: with pipet add in EP pipe successively respectively 800 μ lPBS buffer, 200 μ l variable concentrations natural emulsion (each concentration is 5,10,30,50,70,100mg/ml), 200 μ l tryrosinases, 6 EP pipes are put into 30 DEG C of water-baths and keep temperature-resistant 30min.
Question response terminates respectively sample liquid-transfering gun to be taken out 200 μ l afterwards, joins in 96 orifice plates, and each group sample repeats 3 times, then with the absorbance of microplate reader each group of 475nm place survey.
Tryrosinase vigor=[(A-B)/A] × l00%
Wherein, the light absorption value that " A " is experimental group, the light absorption value that " B " is matched group.Each experiment do 3 parallel.
As shown in Figure 1, as can be seen from experimental data, natural emulsion has good inhibitory action to tryrosinase to experimental result, and along with the increase of concentration, the inhibitory action of tryrosinase is strengthened, can find out, when concentration is 100mg/mL, this natural emulsion is suitable with vitamin C effect.
Test example 2, natural emulsion are on the impact of human keratinized cell
List of references method [Yang Chuntao, Yang Zhanli, Mo Liqiu, Zeng Fanqin, Zhang Meifen, Zhang Hui, Han Yanfang, Hu Fen, Lan Aiping, Chen Peixi, Feng Jianqiang. the inflammation damnification effect of the Human keratinocytes of cyclooxygenase 2 mediation chemical hypoxic induction, Chinese Pharmacological Bulletin, 2011,27 (1): 69-73], Cell culture invitro technology and tetrazolium bromide (MTT) colorimetry is adopted, the impact that more natural emulsion and epidermal growth factor grow HACAT and breed.Get natural emulsion appropriate, make solvent with DMEM in high glucose culture medium (serum-free) solution, prepare 5 respectively, 10,30,50,70, the natural emulsion of 100mg/ml, be that the epithelical cell growth factor EGF of 1mg/ml compares with concentration.In 96 orifice plates, immortalization horn cell planting density is 2.2 × 10
4individual mL
-1, 100 μ L are inoculated in every hole, after planting plate 24h, add tested material process 48h, follow-up the same.Negative control group adopts not containing the serum-free DMEM in high glucose medium treatment of any tested material containing immortalization horn cell.
Result is as shown in Figure 2: as can be seen from experimental data, compared with negative control, EGF has the effect significantly improving keratinocyte proliferation, simultaneously, natural emulsion strengthens the proliferation function of horn cell along with the increase of concentration, and when 50mg/mL, facilitation is the strongest.But along with the increase of concentration, natural emulsion can affect the growth of cell, cell survival rate reduces, but still higher than median lethal concentration (cell survival rate is 50%), illustrates that concentration increase does not bring certain cytotoxicity.Can find out, natural emulsion can promote the propagation of horn cell, has certain repair to epiderm skin.
Claims (10)
1. a natural emulsion, it is characterized in that, comprise the component of following weight portion: Fructus Rhodomyrti lactic acid bacteria fermentation extract 5-10 part, Spiraea thunbergii leaf extract 0.3-1.0 part, Germinatus Phragmitis extract 2-7 part, Herba Swertiae bimaculatae extract 0.2-1.0 part, natural macromolecular polymer viscosifier 0.3-1.0 part, polyhydric alcohol 10-15 part and natural plant preservative 0.05-0.3 part.
2. natural emulsion as claimed in claim 1, it is characterized in that, described Fructus Rhodomyrti lactic acid bacteria fermentation extract is after the juice of myrtle fruit peeling adopts lactobacillus 48h fermentation, after the fermentation liquid 4000r/min obtained is centrifugal, get supernatant, adopt the liquid that 0.22 micron membrane filter filtration sterilization obtains.
3. natural emulsion as claimed in claim 1, is characterized in that, described Spiraea thunbergii leaf extract is Spiraea thunbergii leaf, adopts the extracting solution after 95% alcohol heating reflux obtained after concentrated, drying.
4. natural emulsion as claimed in claim 1, is characterized in that, described Germinatus Phragmitis extract is with asparagus spear, after the alcohol extraction of 70%, and concentrated solution obtained after concentrated.
5. natural emulsion as claimed in claim 1, is characterized in that, described Herba Swertiae bimaculatae extract is that Herba Swertiae bimaculatae herb adopts ethyl acetate room temperature, and the extracting solution after dipping obtains after concentrated, drying.
6. natural emulsion as claimed in claim 1, is characterized in that, described natural macromolecular polymer viscosifier is one or more in alginate jelly, Flos Robiniae Pseudoacaciae glue, Semen Lini glue, Abelmoschus manihot （L.） Medic glue;
Described polyhydric alcohol be glycerol, butanediol, pentanediol, hexanediol one or more;
Described natural plant preservative be Chinese prickly ash fruit extract, oil of rosemary one or both.
7. the preparation method of natural emulsion according to claim 1, is characterized in that, comprise the following steps:
S1: take each component according to weight proportion;
S2: by the natural macromolecular polymer viscosifier deionized water dissolving taken, heating, forms liquid one;
S3: the Fructus Rhodomyrti lactic acid bacteria fermentation extract taken, Spiraea thunbergii leaf extract, Germinatus Phragmitis extract, Herba Swertiae bimaculatae extract, polyhydric alcohol are uniformly mixed, obtain thick liquid two;
S4: slowly joined by liquid two in liquid one, stirs, obtains emulsion liquid;
S5: the natural plant preservative taken being added to temperature is in the emulsion liquid of 40 DEG C, is natural emulsion.
8. the preparation method of natural emulsion as claimed in claim 7, is characterized in that, the temperature in described step S2 is 50-75 DEG C.
9. the preparation method of natural emulsion as claimed in claim 7, is characterized in that, the mixing time in described step S4 is 20-40min.
10. the application of natural emulsion according to claim 1 in preparation maintenance, whitening, crease-resistant skin care item.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106309348A (en) * | 2016-09-18 | 2017-01-11 | 诺斯贝尔化妆品股份有限公司 | Pure-amino-acid mild foam cleansing cream with rice fermentation products |
| CN107233241A (en) * | 2016-12-30 | 2017-10-10 | 海南师范大学 | A kind of preparation method and application of the emulsion containing hill gooseberry |
| CN106860233A (en) * | 2017-01-18 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment antiallergy emulsion |
| CN106860111A (en) * | 2017-02-24 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment repair latex |
| CN106860372A (en) * | 2017-02-24 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment repair latex |
| CN108324636A (en) * | 2018-03-23 | 2018-07-27 | 北京明弘科贸有限责任公司 | A kind of skin care compositions and with careful pore effect cosmetic, preparation method |
| CN108653096A (en) * | 2018-07-11 | 2018-10-16 | 中山市智联企业孵化器发展有限公司 | A kind of skin daily nursing liquid and preparation method thereof |
| CN111374930A (en) * | 2018-12-28 | 2020-07-07 | 山东洁士医疗用品有限公司 | Natural plant asparagus mask essence and preparation method thereof |
| CN111329897A (en) * | 2020-04-13 | 2020-06-26 | 广西壮族自治区兽医研究所 | Method for producing flavone by fermenting myrtle through mixed probiotics |
| CN111329897B (en) * | 2020-04-13 | 2022-04-15 | 广西壮族自治区兽医研究所 | Method for producing flavone by fermenting myrtle through mixed probiotics |
| CN111789803A (en) * | 2020-08-28 | 2020-10-20 | 江南大学 | Method for improving tyrosinase inhibition effect of asparagus polyphenol through hydrothermal treatment |
| CN113151067A (en) * | 2021-03-31 | 2021-07-23 | 绽妍生物科技有限公司 | Extraction and separation process of lactobacillus fermentation extract |
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