CN104188857B - Traditional Chinese medicine skin-whitening fleck-banishing cream and preparation method thereof - Google Patents
Traditional Chinese medicine skin-whitening fleck-banishing cream and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine skin-whitening fleck-banishing cream and a preparation method thereof. The skin-whitening fleck-banishing cream comprises the following skin-whitening components: a Chinese angelica extract, a licorice extract, a white peony root extract, a Japanese ampelopsis root extract, a white atractylodes rhizome extract, a polygonatum odoratum extract and a mulberry leaf extract and further comprises an oil phase matrix component and a water phase matrix component. The preparation method comprises the steps of respectively uniformly mixing the oil phase matrix component and the water phase matrix component at a high temperature, adding the oil phase matrix component into the water phase matrix component, uniformly stirring, adding the traditional Chinese medicine skin-whitening components, carrying out vacuum homogeneous emulsification, cooling, adding essence and uniformly mixing to obtain the traditional Chinese medicine skin-whitening fleck-banishing cream. The traditional Chinese medicine skin-whitening fleck-banishing cream disclosed by the invention has very strong skin whitening and fleck banishing effects and is safe and free of stimulation.
Description
Technical field
The invention belongs to cosmetic technical field, relate to a kind of whitening spot-relieving cream and preparation method thereof, particularly with Chinese medicine
Extract is the cream of whitening composition.
Background technology
As the saying goes: a white screening hundred is ugly, the pursuit of the most many people seeking beauty of pale skin, especially for inherently yellow
The Asia women of skin, the most all will can have pale skin quality as the important topic among beauty treatment.Recently as people
The improving constantly of living standard, people are more and more higher to beautiful requirement, and the market share of Whitening, spot class cosmetics is all the time
It is in the trend of quickly growth.
Whitening active ingredients in skin-lightening cosmetic has hydrargyrum compounds, parahormone and hydroquinone etc. in early days, and these are changed
Compound general action is rapid, and whitening effect is obvious, but its toxicity is big, deposits the most in vivo, causes human body viscera exhaustion, or to skin
Skin zest is big, is easily caused cytopathy, is prohibited use by countries in the world.The skin-whitening added in cosmetics at present
Agent should meet two standards: one is to have higher suppression ratio to tyrosinase activity, can significantly decrease melanic generation；Two
It is to have higher safety, nonirritant nontoxic to human body skin.Prepare a kind of nontoxic non-stimulated as can be seen here and have good
The skin whitener of good whitening effect can extremely people's favor.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine whitening spot-relieving cream.
Another object of the present invention is to provide the preparation method of a kind of Chinese medicine whitening spot-relieving cream.
The technical solution used in the present invention is:
A kind of Chinese medicine whitening spot-relieving cream, containing Radix Angelicae Sinensis extract, Radix Glycyrrhizae extract, Radix Paeoniae Alba extract, Radix Ampelopsis extract, white
Art extract, Rhizoma Polygonati Odorati extract and Folium Mori extract.
Further, above-mentioned Chinese medicine whitening spot-relieving cream, according to the mass fraction, its by Chinese medicine whitening component 0.5～5.0 parts,
Oil phase substrate component 8.8～22.65 parts and aqueous phase substrate component 72.35～90.7 parts of compositions；Wherein, Chinese medicine whitening component by with
The proportioning raw materials composition of lower mass parts: Radix Angelicae Sinensis extract 1.6～2.4 parts, Radix Glycyrrhizae extract 1.6～2.4 parts, Radix Paeoniae Alba extract
1.6～2.4 parts, Radix Ampelopsis extract 0.8～1.2 parts, Rhizoma Atractylodis Macrocephalae extract 0.8～1.2 parts, Rhizoma Polygonati Odorati extract 0.8～1.2 parts, Mulberry
Leaf extract 0.8～1.2 parts.
Further, above-mentioned oil phase substrate component is made up of the proportioning raw materials of following mass parts: stearic acid 0～3.0 parts,
Cera Flava 0～2.0 parts, white oil 1.0～3.0 parts, hexadecanol 1.0～4.0 parts, Arlacel-60 0.2～0.5 part, glycerol monostearate
Ester 0.5～2.0 parts, olive oil 0.5～1.5 parts, dimethicone 0.5～1.5 parts, methyl hydroxybenzoate 0.05～0.15 part, Buddhist nun
Pool gold propyl ester 0.05～0.15 part.
Further, above-mentioned aqueous phase substrate is made up of the proportioning raw materials of following mass parts: glycerol 0.5～1.5 parts, and the third two
Alcohol 0.5～1.0 parts, water solublity Jojoba oil 0.5～2.0 parts, hyaluronic acid 0.5～2.0 parts, Tween-60 0.5～2.0 parts,
Carbopol 940 0～0.5 part, triethanolamine 0.1～0.5 part, essence 0.05～0.2 part, water 60.0～83.8 parts.
The preparation method of a kind of Chinese medicine whitening spot-relieving cream, comprises the following steps:
1) each raw material of Chinese medicine whitening component, mix homogeneously is weighed by above-mentioned Chinese medicine whitening component raw material proportioning；
2) weigh each raw material of oil phase substrate component by above-mentioned oil phase substrate component raw material proportioning, join in oil phase pot,
It is heated to 80～90 DEG C, stirs；
3) each raw material of aqueous phase substrate component is weighed by above-mentioned aqueous phase substrate component raw material proportioning, by other except essence
Raw material all joins in aqueous phase pot, is heated to 80～90 DEG C, stirs；
4) under agitation, oil phase substrate component is added slowly in aqueous phase substrate component, continues stirring 5～10min, so
After Chinese medicine whitening component is added in substrate, stir；
5) said mixture is carried out vacuum emulsifying 5～10min；Being cooled to 40～50 DEG C, add essence, stirring is all
Even, it is cooled to room temperature, obtains Chinese medicine whitening spot-relieving cream；Wherein, Chinese medicine whitening component, oil phase substrate component and aqueous phase substrate component
Mass ratio is (0.5～5): (8.8～22.65): (72.35～90.7).
The invention has the beneficial effects as follows:
1) selection of the Chinese medicine whitening component of the present invention is to use tyrosinase activity suppression method to have whitening effect to multiple
Chinese medicine extract detect, filtered out Radix Angelicae Sinensis extract, Radix Glycyrrhizae extract, Radix Paeoniae Alba extract, Radix Ampelopsis extract, the Rhizoma Atractylodis Macrocephalae
Extract, Rhizoma Polygonati Odorati extract, Folium Mori extract, and according to the mass ratio composition of prescription of 2:2:2:1:1:1:1, be mixed to prepare.
Currently without by above 7 kinds of Drug combinations in Whitening, spot series products, and Chinese medicine whitening spot-relieving cream tool prepared by the present invention
There is the strongest Whitening, spot effect, safe and non-stimulating.
2) the invention provides a kind of prepared, whitening spot-relieving cream safely and efficiently by plurality of Chinese extract, except whitening
Can also skin-moisturizing, skin outside light speckle.It is using Chinese medicine extract as whitening product additive, and because its toxic and side effects is little, safety is high,
Economical and effective, has also conformed to the consumer psychology of trend and the people currently gone back to nature simultaneously, has the biggest development to dive
Power.
Accompanying drawing explanation
Fig. 1 is that different sample is on the impact of melanin content between guinea pig skin corium and epidermis；
Fig. 2 is that different sample is on Cavia porcellus hair follicle and the impact of melanin content in hair；
Fig. 3 is to use the situation of change of mottle melanocyte after different whitening product；
Fig. 4 is melanotic nevus and the change of surrounding skin color thereof after the Chinese medicine whitening spot-relieving cream using embodiment 2 preparation.
Detailed description of the invention
The present invention is built upon on the basis of skin-whitening mechanism studies for a long period of time by Chinese medicine, becoming with reference to modern pharmacological research
Really, biochemical enzyme process (tyrosinase activity suppression method) is used to filter out the Chinese medicine extract of 7 kinds of Whitening, spots, and compatible combination
Prepare Chinese medicine whitening spot-relieving cream.
The mechanism of action that the Chinese medicine whitening spot-relieving cream of the present invention is possible
In Chinese medicine, Radix Angelicae Sinensis is in addition to having blood activating and promoting tissue regeneration, anti-inflammation, regulation body's immunity, and also speckle dispelling increases
White effect, this mainly due in Radix Angelicae Sinensis containing the material of 2-hydroxyl-4 methoxybenzene based structures and aldehydes matter all to cheese ammonia
Acid enzyme has inhibitory action.Radix Glycyrrhizae is conventional a herb, and it is extraordinary whitening raw material that research has proven to its extract, has
The multiple efficacies such as antiinflammatory, skin moistening, scavenging activated oxygen, preferable protectiving ultraviolet.The Radix Paeoniae Alba, Radix Ampelopsis, the Rhizoma Atractylodis Macrocephalae are all traditional profits
Pool skin, the medicine of Whitening, spot, have use, theory of Chinese medical science to think in multiple skin Caring sides such as the seven of ancient times dissipate in vain, beautiful face dissipates
These medicines can treat shallow complexion, facial colour spot, tarnish.Shennong's Herbal cloud: " clothes go dark complexion dim to Rhizoma Polygonati Odorati for a long time, good face
Color, moist, make light of one's life by commiting suicide the oldest ", illustrate that Rhizoma Polygonati Odorati has the beauty treatment effect of prolonging life.Modern study shows, Rhizoma Polygonati Odorati containing convallarin, Flos Camelliae Japonicae phenolic glycoside,
The compositions such as d-quercitol glycosides, provitamin A, lymphatic temperament.Vitamin A can be converted into after provitamin A entrance is internal, help and improve skin
Skin situation dry and cracked, coarse, makes skin tender, and lymphatic temperament then can make skin satiny.Chinese medicine and pharmacy is thought, Folium Mori nature and flavor are bitter, sweet,
Cold, there are scattered wind heat extraction, effect of liver heat removing and eyesight improving.Research in recent years proves, Folium Mori also have good beautifying skin effect, especially
It is that the acne to face, brown macules have reasonable curative effect.
Chinese medicine whitening spot-relieving cream of the present invention may further promote the cutin containing melanocyte in addition to suppressing melanic synthesis
Cell detachment, or make the melanocyte Melanogenic ability of product be restricted, thus reach skin whitening effect.
Below in conjunction with specific embodiment, the present invention is further illustrated, but is not limited thereto.
Embodiment 1
1) composition each raw material of Chinese medicine whitening component mix homogeneously are weighed by following proportion by weight:
Radix Angelicae Sinensis extract 2.0 parts, Radix Glycyrrhizae extract 2.0 parts, Radix Paeoniae Alba extract 2.0 parts, Radix Ampelopsis extract 1.0 parts, the Rhizoma Atractylodis Macrocephalae
Extract 1.0 parts, Rhizoma Polygonati Odorati extract 1.0 parts, Folium Mori extract 1.0 parts；
2) by following proportion by weight weigh composition oil phase substrate component each raw material: 0.5 part of Cera Flava, white oil 3.0 parts, ten
Six alcohol 1.5 parts, Arlacel-60 0.5 part, glyceryl monostearate 1.0 parts, 0.5 part of olive oil, dimethicone 2.0 parts, Ni Bo
Tortoise beetle ester 0.1 part, propylparaben 0.1 part；Each raw material is joined in oil phase pot, is heated to 80～90 DEG C, stirs；
3) by following proportion by weight weigh composition aqueous phase substrate component each raw material: glycerol 1.5 parts, propylene glycol 0.5 part,
Water solublity Jojoba oil 2.0 parts, hyaluronic acid 0.5 part, Tween-60 1.0 parts, carbopol 940 0.2 part, triethanolamine 0.2 part,
0.1 part of essence, distilled water 83.8 parts；Other raw materials except essence are all joined in aqueous phase pot, are heated to 80～90 DEG C,
Stir；
4) under agitation, oil phase substrate component is added slowly in aqueous phase substrate component, continues stirring 5 min, then
Chinese medicine whitening component is added in substrate, stirs；
5) said mixture is carried out vacuum emulsifying 5～10min；Being cooled to 40～50 DEG C, add essence, stirring is all
Even, it is cooled to room temperature, obtains Chinese medicine whitening spot-relieving cream；Wherein, Chinese medicine whitening component, oil phase substrate component and aqueous phase substrate component
Mass ratio is 1:9.2:89.8.
Embodiment 2
1) composition each raw material of Chinese medicine whitening component mix homogeneously are weighed by following proportion by weight:
Radix Angelicae Sinensis extract 2.0 parts, Radix Glycyrrhizae extract 2.0 parts, Radix Paeoniae Alba extract 2.0 parts, Radix Ampelopsis extract 1.0 parts, the Rhizoma Atractylodis Macrocephalae
Extract 1.0 parts, Rhizoma Polygonati Odorati extract 1.0 parts, Folium Mori extract 1.0 parts；
2) by following proportion by weight weigh composition oil phase substrate component each raw material: 1.0 parts of Cera Flava, white oil 3.0 parts, ten
Six alcohol 1.8 parts, Arlacel-60 1.5 parts, glyceryl monostearate 2.0 parts, 1.0 parts of olive oil, dimethicone 1.0 parts, Ni Bo
Tortoise beetle ester 0.15 part, propylparaben 0.15 part；Being joined in oil phase pot by each raw material, be heated to 80～90 DEG C, stirring is all
Even；
3) by following proportion by weight weigh composition aqueous phase substrate component each raw material: glycerol 2.0 parts, propylene glycol 1.0 parts,
Water solublity Jojoba oil 1.0 parts, hyaluronic acid 1.0 parts, Tween-60 2.0 parts, carbopol 940 0.3 part, triethanolamine 0.3 part,
0.1 part of essence, distilled water 77.7 parts；Other raw materials except essence are all joined in aqueous phase pot, are heated to 80～90 DEG C,
Stir；
4) under agitation, oil phase substrate component is added slowly in aqueous phase substrate component, continues stirring 5min, then will
Chinese medicine whitening component adds in substrate, stirs；
5) said mixture is carried out vacuum emulsifying 5～10min；Being cooled to 40～50 DEG C, add essence, stirring is all
Even, it is cooled to room temperature, obtains Chinese medicine whitening spot-relieving cream；Wherein, Chinese medicine whitening component, oil phase substrate component and aqueous phase substrate component
Mass ratio is 3:11.6:85.4.
Embodiment 3
1) composition each raw material of Chinese medicine whitening component mix homogeneously are weighed by following proportion by weight:
Radix Angelicae Sinensis extract 2.0 parts, Radix Glycyrrhizae extract 2.0 parts, Radix Paeoniae Alba extract 2.0 parts, Radix Ampelopsis extract 1.0 parts, the Rhizoma Atractylodis Macrocephalae
Extract 1.0 parts, Rhizoma Polygonati Odorati extract 1.0 parts, Folium Mori extract 1.0 parts；
2) by following proportion by weight weigh composition oil phase substrate component each raw material: stearic acid 3.0 parts, white oil 2.0 parts,
Hexadecanol 3.0 parts, Arlacel-60 1.0 parts, glyceryl monostearate 1.0 parts, 1.0 parts of olive oil, dimethicone 1.5 parts, Buddhist nun
Pool tortoise beetle ester 0.1 part, propylparaben 0.1 part；Being joined in oil phase pot by each raw material, be heated to 80～90 DEG C, stirring is all
Even；
3) by following proportion by weight weigh composition aqueous phase substrate component each raw material: glycerol 1.5 parts, propylene glycol 1.5 parts,
Water solublity Jojoba oil 1.0 parts, hyaluronic acid 1.0 parts, Tween-60 1.0 parts, triethanolamine 0.15 part, 0.1 part of essence, steams
Distilled water 79.05 parts；Other raw materials except essence are all joined in aqueous phase pot, is heated to 80～90 DEG C, stirs；
4) under agitation, oil phase substrate component is added slowly in aqueous phase substrate component, continues stirring 5 min, then
Chinese medicine whitening component is added in substrate, stirs；
5) said mixture is carried out vacuum emulsifying 5～10min；Being cooled to 40～50 DEG C, add essence, stirring is all
Even, it is cooled to room temperature, obtains Chinese medicine whitening spot-relieving cream；Wherein, Chinese medicine whitening component, oil phase substrate component and aqueous phase substrate component
Mass ratio is 2:12.7:85.3.
Embodiment 4
1) composition each raw material of Chinese medicine whitening component mix homogeneously are weighed by following proportion by weight:
Radix Angelicae Sinensis extract 2.0 parts, Radix Glycyrrhizae extract 2.0 parts, Radix Paeoniae Alba extract 2.0 parts, Radix Ampelopsis extract 1.0 parts, the Rhizoma Atractylodis Macrocephalae
Extract 1.0 parts, Rhizoma Polygonati Odorati extract 1.0 parts, Folium Mori extract 1.0 parts；
2) by following proportion by weight weigh composition oil phase substrate component each raw material: stearic acid 4.0 parts, white oil 2.0 parts,
Hexadecanol 3.0 parts, Arlacel-60 1.0 parts, glyceryl monostearate 1.0 parts, 1.0 parts of olive oil, dimethicone 2.0 parts, Buddhist nun
Pool tortoise beetle ester 0.15 part, propylparaben 0.15 part；Each raw material is joined in oil phase pot, is heated to 80～90 DEG C, stirring
Uniformly；
3) by following proportion by weight weigh composition aqueous phase substrate component each raw material: glycerol 1.0 parts, propylene glycol 1.0 parts,
Water solublity Jojoba oil 1.5 parts, hyaluronic acid 0.5 part, Tween-60 1.0 parts, triethanolamine 0.15 part, 0.1 part of essence, steams
Distilled water 76.45 parts；Other raw materials except essence are all joined in aqueous phase pot, is heated to 80～90 DEG C, stirs；
4) under agitation, oil phase substrate component is added slowly in aqueous phase substrate component, continues stirring 5 min, then
Chinese medicine whitening component is added in substrate, stirs；
5) said mixture is carried out vacuum emulsifying 5～10min；Being cooled to 40～50 DEG C, add essence, stirring is all
Even, it is cooled to room temperature, obtains Chinese medicine whitening spot-relieving cream；Wherein, Chinese medicine whitening component, oil phase substrate component and aqueous phase substrate component
Mass ratio is 4:14.3:81.7.
Embodiment 5
1) composition each raw material of Chinese medicine whitening component mix homogeneously are weighed by following proportion by weight:
Radix Angelicae Sinensis extract 2.0 parts, Radix Glycyrrhizae extract 2.0 parts, Radix Paeoniae Alba extract 2.0 parts, Radix Ampelopsis extract 1.0 parts, the Rhizoma Atractylodis Macrocephalae
Extract 1.0 parts, Rhizoma Polygonati Odorati extract 1.0 parts, Folium Mori extract 1.0 parts；
2) by following proportion by weight weigh composition oil phase substrate component each raw material: stearic acid 1.0 parts, 0.5 part of Cera Flava,
White oil 1.0 parts, hexadecanol 1.5 parts, Arlacel-60 1.0 parts, glyceryl monostearate 1.0 parts, 0.5 part of olive oil, dimethyl-silicon
Oil 2.0 parts, methyl hydroxybenzoate 0.15 part, propylparaben 0.15 part；Each raw material is joined in oil phase pot, be heated to 80～
90 DEG C, stir；
3) by following proportion by weight weigh composition aqueous phase substrate component each raw material: glycerol 1.0 parts, propylene glycol 0.5 part,
Water solublity Jojoba oil 3.0 parts, hyaluronic acid 0.5 part, Tween-60 2.0 parts, carbopol 940 0.2 part, triethanolamine 0.3 part,
0.1 part of essence, distilled water 80.6 parts；Other raw materials except essence are all joined in aqueous phase pot, are heated to 80～90 DEG C,
Stir；
4) under agitation, oil phase substrate component is added slowly in aqueous phase substrate component, continues stirring 5 min, then
Chinese medicine whitening component is added in substrate, stirs；
5) said mixture is carried out vacuum emulsifying 5～10min；Being cooled to 40～50 DEG C, add essence, stirring is all
Even, it is cooled to room temperature, obtains Chinese medicine whitening spot-relieving cream；Wherein, Chinese medicine whitening component, oil phase substrate component and aqueous phase substrate component
Mass ratio is 3:8.8:88.2.
Embodiment 6
1) composition each raw material of Chinese medicine whitening component mix homogeneously are weighed by following proportion by weight:
Radix Angelicae Sinensis extract 2.0 parts, Radix Glycyrrhizae extract 2.0 parts, Radix Paeoniae Alba extract 2.0 parts, Radix Ampelopsis extract 1.0 parts, the Rhizoma Atractylodis Macrocephalae
Extract 1.0 parts, Rhizoma Polygonati Odorati extract 1.0 parts, Folium Mori extract 1.0 parts；
2) by following proportion by weight weigh composition oil phase substrate component each raw material: stearic acid 3.0 parts, white oil 1.0 parts,
Hexadecanol 2.0 parts, Arlacel-60 1.0 parts, glyceryl monostearate 0.75 part, 0.5 part of olive oil, dimethicone 1.0 parts, Buddhist nun
Pool tortoise beetle ester 0.15 part, propylparaben 0.15 part；Each raw material is joined in oil phase pot, is heated to 80～90 DEG C, stirring
Uniformly；
3) by following proportion by weight weigh composition aqueous phase substrate component each raw material: glycerol 0.5 part, propylene glycol 0.5 part,
Water solublity Jojoba oil 2.0 parts, hyaluronic acid 0.5 part, Tween-60 1.0 parts, carbopol 940 0.2 part, triethanolamine 0.3 part,
0.1 part of essence, distilled water 80.35 parts；Other raw materials except essence are all joined in aqueous phase pot, are heated to 80～90 DEG C,
Stir；
4) under agitation, oil phase substrate component is added slowly in aqueous phase substrate component, continues stirring 5 min, then
Chinese medicine whitening component is added in substrate, stirs；
5) said mixture is carried out vacuum emulsifying 5～10min；Being cooled to 40～50 DEG C, add essence, stirring is all
Even, it is cooled to room temperature, obtains Chinese medicine whitening spot-relieving cream；Wherein, Chinese medicine whitening component, oil phase substrate component and aqueous phase substrate component
Mass ratio is 5:9.55:85.45.
Embodiment 7
1) composition each raw material of Chinese medicine whitening component mix homogeneously are weighed by following proportion by weight:
Radix Angelicae Sinensis extract 2.0 parts, Radix Glycyrrhizae extract 2.0 parts, Radix Paeoniae Alba extract 2.0 parts, Radix Ampelopsis extract 1.0 parts, the Rhizoma Atractylodis Macrocephalae
Extract 1.0 parts, Rhizoma Polygonati Odorati extract 1.0 parts, Folium Mori extract 1.0 parts；
2) by following proportion by weight weigh composition oil phase substrate component each raw material: stearic acid 6.0 parts, white oil 1.0 parts,
Hexadecanol 6.0 parts, Arlacel-60 1.0 parts, glyceryl monostearate 4.85 parts, 0.5 part of olive oil, dimethicone 3.0 parts, Buddhist nun
Pool tortoise beetle ester 0.15 part, propylparaben 0.15 part；Each raw material is joined in oil phase pot, is heated to 80～90 DEG C, stirring
Uniformly；
3) by following proportion by weight weigh composition aqueous phase substrate component each raw material: glycerol 5.0 parts, propylene glycol 3.5 parts,
Water solublity Jojoba oil 2.0 parts, hyaluronic acid 0.5 part, Tween-60 1.0 parts, carbopol 940 0.2 part, triethanolamine 0.2 part,
0.1 part of essence, distilled water 59.85 parts (mass parts and must be not necessarily 72.35) herein；By former for other except essence
Material all joins in aqueous phase pot, is heated to 80～90 DEG C, stirs；
4) under agitation, oil phase substrate component is added slowly in aqueous phase substrate component, continues stirring 5 min, then
Chinese medicine whitening component is added in substrate, stirs；
5) said mixture is carried out vacuum emulsifying 5～10min；Being cooled to 40～50 DEG C, add essence, stirring is all
Even, it is cooled to room temperature, obtains Chinese medicine whitening spot-relieving cream；Wherein, Chinese medicine whitening component, oil phase substrate component and aqueous phase substrate component
Mass ratio is 5:22.65:72.35.
Embodiment 8
1) composition each raw material of Chinese medicine whitening component mix homogeneously are weighed by following proportion by weight:
Radix Angelicae Sinensis extract 2.0 parts, Radix Glycyrrhizae extract 2.0 parts, Radix Paeoniae Alba extract 2.0 parts, Radix Ampelopsis extract 1.0 parts, the Rhizoma Atractylodis Macrocephalae
Extract 1.0 parts, Rhizoma Polygonati Odorati extract 1.0 parts, Folium Mori extract 1.0 parts；
2) by following proportion by weight weigh composition oil phase substrate component each raw material: stearic acid 5.0 parts, white oil 1.0 parts,
Hexadecanol 5.0 parts, Arlacel-60 1.0 parts, glyceryl monostearate 3.75 parts, 0.5 part of olive oil, dimethicone 1.0 parts, Buddhist nun
Pool tortoise beetle ester 0.15 part, propylparaben 0.15 part；Each raw material is joined in oil phase pot, is heated to 80～90 DEG C, stirring
Uniformly；
3) by following proportion by weight weigh composition aqueous phase substrate component each raw material: glycerol 3.5 parts, propylene glycol 3.5 parts,
Water solublity Jojoba oil 2.0 parts, hyaluronic acid 0.5 part, Tween-60 1.0 parts, carbopol 940 0.2 part, triethanolamine 0.3 part,
0.1 part of essence, distilled water 70.85 parts；Other raw materials except essence are all joined in aqueous phase pot, are heated to 80～90 DEG C,
Stir；
4) under agitation, oil phase substrate component is added slowly in aqueous phase substrate component, continues stirring 5 min, then
Chinese medicine whitening component is added in substrate, stirs；
5) said mixture is carried out vacuum emulsifying 5～10min；Being cooled to 40～50 DEG C, add essence, stirring is all
Even, it is cooled to room temperature, obtains Chinese medicine whitening spot-relieving cream；Wherein, Chinese medicine whitening component, oil phase substrate component and aqueous phase substrate component
Mass ratio is 0.5:17.55:81.95.
Below the Chinese medicine whitening spot-relieving cream prepared by above-described embodiment is made further effect detection.
The present invention is built upon on the basis of skin-whitening mechanism studies for a long period of time by Chinese medicine, becoming with reference to modern pharmacological research
Really, use biochemical enzyme process to filter out the Chinese medicine extract of 7 kinds of Whitening, spots, and compatible combination prepare Chinese medicine whitening spot-relieving cream,
Through zoopery and normal individual trial experimental verification, it is safe and non-stimulating, Whitening, spot is respond well.
One, Cavia porcellus whitening effect investigates experiment
Taking each 10 of black Cavia porcellus male and female, body weight is 250～350g, divides 5 groups, often group 4, and respectively embodiment 1 is low
Dosage Chinese medicine skin whitener group (1%), middle dosage Chinese medicine skin whitener group (3%) of embodiment 2, the high dose Chinese medicine whitening of embodiment 6
Frost group (5%), positive arbutin skin whitener group and blank group.Administration group becomes the unhairing of 3cm × 3cm size in both sides, back shaving
District, takes experiment reagent by swab stick uniform at arranged on left and right sides dermal application, every day 2 times.Naive animals to take off in both sides equally
Hair, and ensure that other experiment conditions compare with being identically formed of experimental group.
In Cavia porcellus feeding process, to strictly control indoor temperature and be maintained at about 25 DEG C, relative humidity be maintained at 50%～
Between 60%, every Cavia porcellus is taken food feedstuff 10～15g, Radix Dauci Sativae or vegetable 10～15g every time, the endless supply of water.
After 28 days, take guinea pig skin living tissue, fix with 10% formalin, paraffin embedding, cut into slices, observe.Right
Section after ferrous sulfate dyeing carries out microscope and takes pictures (as depicted in figs. 1 and 2), uses Image-Pro Plus6.0 afterwards
Software, to analysis of being taken a picture, uses optical density/section area and optical density/melanocyte area to characterize melanin content.Each
40 photos of slide random shooting carry out processing statistical analysis.Result such as following table:
Table 1 different group contrast of melanocyte value after ferrous sulfate absorption process dyes
Note: * represents that P ＜ 0.05, * * represent that P ＜ 0.01, * * * represents P ＜ 0.001, n=40.
From result above it will be seen that either from optical density/section area or the angle of optical density/melanocyte area
Degree is analyzed, and blank group is compared with experimental group obvious difference, same group of experiment female and male between difference not
Greatly, also illustrate that this Chinese medicine skin whitener will not have sex selectively acting.Positive arbutin group and middle dosage group (embodiment 2), height
But the result of the Chinese medicine skin whitener of dosage group (embodiment 6) has difference hardly differs；Simultaneously all than low dosage (embodiment 1)
Action intensity is high, can illustrate that the whitening function of this Chinese medicine skin whitener is relevant with the content of Chinese medicine extract from this result.
Finding out (such as Fig. 1 and Fig. 2) from made slide, collagen fiber are red, muscle fiber yellow, and melanin presents green to blackish green,
Melanocyte is distributed mainly on inside corium and epidermal junction and hair.Low dose group and the hair of blank group as seen from Figure 2
In capsule and hair, melanin content is the highest, and concentration is compared in distribution；Comparing of basic, normal, high three dosage, it can be seen that melanin
Content is dense to be declined successively, and the Rhizoma Imperatae core pigment of middle dosage and high dose group then becomes obvious rareness, at epidermis
Pigment content is relatively low.Result shows that Chinese medicine skin whitener whitening effect is good.
Two, normal individual trial experiment
Selecting 4 volunteers having mottle, skin health is without photosensitivity, without cosmetic allergic contact dermatitis history, medicine-less allergy history.Real
Before testing beginning, use CBS-902 skinanalysis apparatus detection mottle melanocyte, primary data can be obtained as absolute reference value.Often
Chinese medicine whitening spot-relieving cream and the commercially available whitening product 1(nature hall snow embodiment 2 prepared after it morning and evening cleaning skin moisten fair-skinned white crystalline substance
Color frost), the commercially available whitening product clear skin whitener of 2(Avene), with about 0.025g/cm2Amount uniform application in test position, continuously
8 weeks.Experiment detects the change of mottle melanin content every three days with CBS-902 skinanalysis apparatus after starting, and does according to change
Go out curve.Volunteer through 8 weeks experiment after skin pigment changes of contents situation as shown in Figure 3 and Figure 4.
As can be seen from Figure 3 three kinds of products have whitening function to skin splash, after using 8 weeks, and product 1 mottle pigment
Reducing by 17%, product 2 is low by 14%, and Chinese medicine skin whitener reduces by 20%, but the onset time of different product is different, the Chinese medicine of the present invention
Whitening spot-relieving cream onset time is later, just has obvious change after using one month.Through the analysis of 8 weeks, Chinese medicine whitening
Frost has significantly effect to mottle, and the skin colourity in pilot region is decreased obviously (as shown in Figure 4).Chinese medicine whitening of the present invention
Light speckle frost may further promote the horn cell containing melanocyte in addition to suppressing melanic synthesis and come off, or makes melanin thin
Born of the same parents produce Melanogenic ability and are restricted, thus reach skin whitening effect.Also indicate that, for whitening class cosmetics, mostly simultaneously
The qualified series products of number can play whitening effect, but requires that consumer in use to take suitable method, and hard
Hold use, if method is incorrect, or stop using again after use a period of time, be then difficult to reach whitening effect.
Claims (4)
1. a Chinese medicine whitening spot-relieving cream, it is characterised in that: according to the mass fraction, its by Chinese medicine whitening component 0.5～5.0 parts,
Oil phase substrate component 8.8～22.65 parts and aqueous phase substrate component 72.35～90.7 parts of compositions；
Wherein, Chinese medicine whitening component is made up of the proportioning raw materials of following mass parts: Radix Angelicae Sinensis extract 1.6～2.4 parts, Radix Glycyrrhizae extraction
Thing 1.6～2.4 parts, Radix Paeoniae Alba extract 1.6～2.4 parts, Radix Ampelopsis extract 0.8～1.2 parts, Rhizoma Atractylodis Macrocephalae extract 0.8～1.2 parts,
Rhizoma Polygonati Odorati extract 0.8～1.2 parts, Folium Mori extract 0.8～1.2 parts.
A kind of Chinese medicine whitening spot-relieving cream the most according to claim 1, it is characterised in that: described oil phase substrate component is by following
Mass parts proportioning raw materials composition: stearic acid 0～3.0 parts, Cera Flava 0～2.0 parts, white oil 1.0～3.0 parts, hexadecanol 1.0～
4.0 parts, Arlacel-60 0.2～0.5 part, glyceryl monostearate 0.5～2 parts, olive oil 0.5～1.5 parts, dimethicone
0.5～1.5 part, methyl hydroxybenzoate 0.05～0.15 part, propylparaben 0.05～0.15 part.
A kind of Chinese medicine whitening spot-relieving cream the most according to claim 1, it is characterised in that: described aqueous phase substrate is by following quality
The proportioning raw materials composition of part: glycerol 0.5～1.5 parts, propylene glycol 0.5～1.0 parts, water solublity Jojoba oil 0.5～2.0 parts, thoroughly
Bright matter acid 0.5～2.0 part, Tween-60 0.5～2.0 parts, carbopol 940 0～0.5 part, triethanolamine 0.1～0.5 part are fragrant
Essence 0.05～0.2 part, water 60.0～83.8 parts.
4. the preparation method of a kind of Chinese medicine whitening spot-relieving cream described in any one of claims 1 to 3, it is characterised in that: include following
Step:
1) proportioning raw materials as described in claim 1 weighs each raw material of Chinese medicine whitening component, mix homogeneously；
2) proportioning raw materials as described in claim 2 weighs each raw material of oil phase substrate component, joins in oil phase pot, is heated to
80～90 DEG C, stir；
3) proportioning raw materials as described in claim 3 weighs each raw material of aqueous phase substrate component, by other raw materials except essence
All join in aqueous phase pot, be heated to 80～90 DEG C, stir；
4) under agitation, oil phase substrate component is added slowly in aqueous phase substrate component, continues stirring 5～10min, then will
Chinese medicine whitening component adds in substrate, stirs；
5) said mixture is carried out vacuum emulsifying 5～10min；It is cooled to 40～50 DEG C, adds essence, stir,
It is cooled to room temperature, obtains Chinese medicine whitening spot-relieving cream；Wherein, Chinese medicine whitening component, oil phase substrate component and the matter of aqueous phase substrate component
Amount ratio is (0.5～5): (8.8～22.65): (72.35～90.7).
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| CN106176515A (en) * | 2016-07-27 | 2016-12-07 | 陕西仁康药业有限公司 | A kind of body whitening crème and preparation method thereof |
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