CN103251527B - Cassiabarktree twig extract-containing whitening cosmetic preparation method - Google Patents
Cassiabarktree twig extract-containing whitening cosmetic preparation method Download PDFInfo
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- CN103251527B CN103251527B CN201310052488.8A CN201310052488A CN103251527B CN 103251527 B CN103251527 B CN 103251527B CN 201310052488 A CN201310052488 A CN 201310052488A CN 103251527 B CN103251527 B CN 103251527B
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- 150000003384 small molecules Chemical class 0.000 description 1
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- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 210000000438 stratum basale Anatomy 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
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Abstract
The invention discloses a cassiabarktree twig extract-containing whitening cosmetic preparation method, which comprises: 1, adopting ethanol to extract cassiabarktree twig, Chinese thorowax root, common macrocarpium fruit and rose to obtain an extract; 2, carrying out heating mixing melting on C18 alcohol, inositol hexaphosphate, glycerol and stearic acid, and adding tert-butylhydroquinone to dissolve to obtain an oil phase; 3, adding borax, glyceryl monostearate and refined water to the Chinese herbal extract, and mixing to obtain a water phase; and 4, adding the oil phase to the water phase, carrying out emulsification, and adding flavor to obtain the cosmetic with effects of whitening and spot removing. The cassiabarktree twig extract-containing whitening cosmetic has effects of skin metabolism improvement, skin blood circulation promotion, skin nutrition increase, effective free radical removal, pigmentation elimination, skin wrinkle and color spot fading, and delicate, smooth, white and flexible skin achievement.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically refer to a kind of preparation method of the skin-lightening cosmetic that contains Ramulus Cinnamomi extract.
Background technology
Skin-whitening cosmetic, also referred to as freckle whitening makeup, is classified caused by cosmetics for special use as in China.In skin-whitening cosmetic market, occupy considerable share always, in recent years, along with the development of aesthetic medicine, the welcome of skin-whitening cosmetic Hen Shou consumer.
Skin is the important component part of human body, directly expresses especially health and old and feeble mark.Vigorous when skin metabolism, blood circulation is unimpeded, and when nutritious, skin exquisiteness, smooth, tender, is rich in elasticity, and is not prone to wrinkle and mottle.When skin metabolism weakens, poor blood circulation, when nutrient substance is bad, skin can become gloomy, old and feeble, and easily produces wrinkle and mottle.The principal element of decider's skin colour difference is carotene and melanin, and wherein melanin is most important.Melanin is synthetic in melanocyte, transfers in the keratinocyte of adjacency by the dendritic processes of melanocyte.Melanocyte in application on human skin is positioned at stratum basale, Rhizoma Imperatae portion and outer hair sheath etc., approximately has a melanocyte in 7 ~ 8 basal cells.Therefore, the distribution density of melanocyte is without ethnic group difference, and the people of the various colours of skin is basic identical, approximately 2,000,000,000 altogether of whole bodies.Under normal condition, melanin can absorb excessive daylight light, particularly ultraviolet, protection human body.If the melanin metabolism in time generating and assemble, be deposited on epidermis, can make to occur on skin freckle, chloasma or senile plaque etc.It is generally acknowledged that melanic formation mechanism is that tyrosine synthesizes through tyrosinase catalysis in melanocyte.It is quite complicated that tyrosine is oxidized to melanic process, and ultraviolet can cause the enhancing of activity and the melanocyte activity of tryrosinase, because can promote this Oxidation.
Up to the present, applying whitening agent more widely mainly contains following several: ascorbic acid and derivant thereof, kojic acid and derivant thereof, hydroquinone and derivant thereof, а-hydroxy acid and derivant thereof, animal proteinum extract, Chinese herbal medicine extract and sunscreen.
Current cosmetics, conventionally cannot improve skin metabolism, promote cutaneous circulation, increase skin-nourishing, and the mottle that more cannot remove skin appearance makes skin exquisiteness, smooth, tender white and springiness.Therefore can not meet the whitening of people to skin of face, the skin protection requirement that defying age removes speckle, to people, the daily nursing of skin of face brought to inconvenience.
Summary of the invention
The object of this invention is to provide a kind of preparation method of the skin-lightening cosmetic that contains Ramulus Cinnamomi extract, the cosmetics that the method makes not only can improve skin metabolism, promote cutaneous circulation, increase skin-nourishing, and can remove skin splash, make skin tenderer white.
The present invention is achieved by the following technical solutions:
The preparation method of the skin-lightening cosmetic that contains Ramulus Cinnamomi extract is: the first step: Ramulus Cinnamomi 10 weight portions, Radix Bupleuri 5 weight portions, Fructus Corni 2 weight portions, Flos Rosae Rugosae 2 weight portion mix homogeneously are carried out to 80 orders after pulverizing and sieve, then add the ethanol that 500 weight portion mass concentrations are 85% ~ 90%, soak 24 hours under 25 DEG C of conditions after, carry out low temperature ultrasonic extraction 2 hours, go that supernatant is centrifugal, filtration, backflow ethanol, after secondary filter, obtain Chinese herbal medicine extract; Second step: C18 alcohol 1.5 weight portions, inositol hexaphosphate 0.5 weight portion, glycerol 6 weight portions, stearic acid 12 weight portions are heated to, after 75 DEG C ~ 85 DEG C consolutes, add tertiarybutylhydroquinone 0.02 weight portion, obtain oil phase after dissolving; The 3rd step: add Borax 3 weight portions, glycerol single-hard ester acid ester 2 weight portions, Purified Water 60 weight portions to obtain water after mixing described Chinese herbal medicine extract 3 weight portions; The 4th step: described oil phase is added to emulsifying in the described water of 70 DEG C, add essence in the time that temperature is down to 40 DEG C ~ 50 DEG C, there are the cosmetics of whitening effect described in obtaining.
Wherein, Ramulus Cinnamomi is containing volatile oil 0.69%, and in oil, main component is cinnamic aldehyde 64.75%, also has benzyl benzoate, cinnamyl acetate, β-cadinene, Chang Pu alkene, coumarin etc.Textual criticism: come from Tang Materia Medica." book on Chinese herbal medicine is not mentionleted alone ": Zhong Jing treatise on Febrile Diseases diaphoresis Ramulus Cinnamomi.Ramulus Cinnamomi person, branch, non-body is dry also.Get it frivolous and can disperse.There is again a kind of Liu Gui the present, be the tender small stems in osmanthus also, it is outstanding that pleasant to control the part of the body cavity above the diaphragm housing the heart and lungs also medicinal.There is effect of expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI.Cosmetic result is excellent, can effectively remove free radical, eliminates pigmentation, makes us calling out a youthful vigor.
Its composition of Radix Bupleuri Radix Bupleuri mainly contains saikoside, sterol, volatile oil (bupleurumol, eugenol etc.), fatty acid (oleic acid, linoleic acid, Palmic acid, stearic acid etc.) and polysaccharide etc.Also containing compositions such as flavone, polyhydric alcohol, coumarin and trace element.Meridian distribution of property and flavor: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire.Function: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.
Fructus Corni contains the effective ingredient such as cornin, tartaric acid, gallic acid, malic acid, resin, tannin and the multivitamin that physiologically active is stronger, has the immunity, antiinflammatory of enhancing, the pharmacological action such as antibacterial, is Herba indigoferae Pseudotinctoriae conventional in tcm clinical practice.
Flos Rosae Rugosae containing volatile oil (Oleum Rosae Rugosae), is mainly citronellol, nerol, eugenol, phenethanol, nonyl alcohol, benzyl alcohol, linalool, phenethyl acetate, and the composition such as quercitrin, amaroid, tannin, gallic acid, carotene, red pigment.There is strong liver and nourishing stomach, promoting blood flow to regulate menstruation, loosening bowel to relieve constipation, effect of resolving stagnation for tranquilization, can chill out, balance endocrine, the gas of enriching blood, liver and stomach be had to the effect of conditioning, the emotion of releiving and have anti-inflammation and sterilization, allaying tiredness, improve body constitution, effect of moist skin.
In cosmetic composition of the present invention, contain by Ramulus Cinnamomi, Radix Bupleuri, Fructus Corni, the various plants active ingredient of the Chinese herbal medicine extracting such as Flos Rosae Rugosae, there is very strong antioxidation, and be small-molecule substance, more easily infiltrate skin and absorbed by skin, not only can improve skin metabolism, promote cutaneous circulation, increase skin-nourishing, and can effectively remove free radical, eliminate pigementation, wrinkle and mottle that desalination skin occurs, make skin finer and smoother, smooth, tender white and springiness, can meet easily the whitening of people to skin of face, defying age wrinkle removing goes the daily skin protection requirement of speckle, a kind of novelty the Chinese herbal medicine cosmetic that shows unique characteristics.
Clinical practice shows, the biosynthesis of the cosmetics energy restraint of tyrosinase that contains Ramulus Cinnamomi extract of the present invention comprises the activity of restraint of tyrosinase, the intermediate that disturbs melanin to generate; Can play reduction to melanin, prevent photooxidation, degraded horn cell black plasmid; Can promote melanic metabolism, prevent melanin deposition, melanin is excreted rapidly; Prevent ultraviolet entering, prevent because ultraviolet forms too much melanin, thereby skin is played to effect of whitening and speckle dispelling.
detailed description of the invention:
Below in conjunction with embodiment and case, the present invention is further illustrated.
Embodiment 1
The first step: accurately take Ramulus Cinnamomi 10kg, Radix Bupleuri 5kg, Fructus Corni 2kg, Flos Rosae Rugosae 2kg, mix homogeneously carries out 80 orders after pulverizing and sieves, then adding 500kg mass concentration is 85% ethanol, soak 24 hours under 25 DEG C of conditions after, carry out low temperature ultrasonic extraction 2 hours, go that supernatant is centrifugal, filtration, backflow ethanol, after secondary filter, obtain Chinese herbal medicine extract; Second step: C18 alcohol 1.5kg, inositol hexaphosphate 0.5kg, glycerol 6kg, stearic acid 12kg are heated to, after 75 DEG C of consolutes, add tertiarybutylhydroquinone 0.02kg, obtain oil phase after dissolving; The 3rd step: obtain water after adding Borax 3kg, glycerol single-hard ester acid ester 2kg, Purified Water 60kg to mix described Chinese herbal medicine extract 3kg; The 4th step: described oil phase is added to emulsifying in the described water of 70 DEG C, add essence in the time that temperature is down to 40 DEG C, there are the cosmetics of white-skinned face function described in obtaining.
Embodiment 2
The first step: accurately take Ramulus Cinnamomi 10kg, Radix Bupleuri 5kg, Fructus Corni 2kg, Flos Rosae Rugosae 2kg, mix homogeneously carries out 80 orders after pulverizing and sieves, then adding 500kg mass concentration is 90% ethanol, soak 24 hours under 25 DEG C of conditions after, carry out low temperature ultrasonic extraction 2 hours, go that supernatant is centrifugal, filtration, backflow ethanol, after secondary filter, obtain Chinese herbal medicine extract; Second step: C18 alcohol 1.5 kg, inositol hexaphosphate 0.5 kg, glycerol 6kg, stearic acid 12kg are heated to, after 85 DEG C of consolutes, add tertiarybutylhydroquinone 0.02kg, obtain oil phase after dissolving; The 3rd step: obtain water after adding Borax 3kg, glycerol single-hard ester acid ester 2kg, Purified Water 60kg to mix described Chinese herbal medicine extract 3kg; The 4th step: described oil phase is added to emulsifying in the described water of 70 DEG C, add essence in the time that temperature is down to 50 DEG C, there are the cosmetics of white-skinned face function described in obtaining.
Embodiment 3
The first step: accurately take Ramulus Cinnamomi 10kg, Radix Bupleuri 5kg, Fructus Corni 2kg, Flos Rosae Rugosae 2kg, mix homogeneously carries out 80 orders after pulverizing and sieves, then adding 500kg concentration is 85% ethanol, soak 24 hours under 25 DEG C of conditions after, carry out low temperature ultrasonic extraction 2 hours, go that supernatant is centrifugal, filtration, backflow ethanol, after secondary filter, obtain Chinese herbal medicine extract; Second step: C18 alcohol 1.5kg, inositol hexaphosphate 0.5kg, glycerol 6kg, stearic acid 12kg are heated to, after 85 DEG C of consolutes, add tertiarybutylhydroquinone 0.02kg, obtain oil phase after dissolving; The 3rd step: obtain water after adding Borax 3kg, glycerol single-hard ester acid ester 2kg, Purified Water 60kg to mix described Chinese herbal medicine extract 3kg; The 4th step: described oil phase is added to emulsifying in the described water of 70 DEG C, add essence in the time that temperature is down to 45 DEG C, there are the cosmetics of white-skinned face function described in obtaining.
Embodiment 4
The first step: accurately take Ramulus Cinnamomi 10kg, Radix Bupleuri 5kg, Fructus Corni 2kg, Flos Rosae Rugosae 2kg, mix homogeneously carries out 80 orders after pulverizing and sieves, then adding 500kg concentration is 87% ethanol, soak 24 hours under 25 DEG C of conditions after, carry out low temperature ultrasonic extraction 2 hours, go that supernatant is centrifugal, filtration, backflow ethanol, after secondary filter, obtain Chinese herbal medicine extract; Second step: C18 alcohol 1.5kg, inositol hexaphosphate 0.5kg, glycerol 6kg, stearic acid 12kg are heated to, after 80 DEG C of consolutes, add tertiarybutylhydroquinone 0.02kg, obtain oil phase after dissolving; The 3rd step: obtain water after adding Borax 3kg, glycerol single-hard ester acid ester 2kg, Purified Water 60kg to mix described Chinese herbal medicine extract 3kg; The 4th step: described oil phase is added to emulsifying in the described water of 70 DEG C, add essence in the time that temperature is down to 47 DEG C, there are the cosmetics of white-skinned face function described in obtaining.
Human body whitening test--melanin content reduces:
Before measuring tested position, within 2-3 days, can not use any product (cosmetics or topical drug).Before test, experimenter need to unify clean both hands forearm inner side, by dry medicated napkin wiped clean.After clean, carry out measured zone labelling in experimenter's both hands forearm inner side.At least 30min that should sit quietly in standard compliant room before official testing, forearm exposes, and is test mode and places, and keeps loosening.
Labelling 4 × 4cm2 pilot region inside right-hand man's forearm in experiment, same arm can be with the multiple regions of tense marker, interregional every 2cm.Test products (extracting solution of variable concentrations) and blank are all randomly dispersed on the arm of left and right.Use dermal melanin and haemachrome tester to carry out the measurement of tested region and control zone, each region is according to parallel assay 5 times.First measure the blank value of each test zone, then by the consumption of 2.0 ± 0.1mg sample/cm2, use latex finger cot that sample is evenly coated in trial zone.Smear the rear dermal melanin content of measuring respectively 1 week, 2 weeks, 3 weeks, 4 weeks, tested region and blank region.Same volunteer's test is completed by same survey crew.
The experimental result of the embodiment of the present invention 1 ~ 4: along with the prolongation of Measuring Time, melanin content reduction also increases gradually, the whitening active component of the cosmetics that this explanation embodiment of the present invention 1 ~ 4 makes continues the melanin of skin to reduce and work.
Clinical experiment of the present invention and result:
Experimental technique: select age bracket at the volunteer of 35 years old to 60 years old, 50 of male volunteers, 50 of female's volunteers.
Cardinal symptom: freckle, chloasma, sun speckle, the colour of skin are obscure.Volunteer is divided into two groups at random, every group of 50 people.
Test group: after clean of every day, the facial film of before sleeping being prepared by embodiment 4 spreads on the 20～30min of face, with warm water cleaning, does not apply other skin care item.2～3 times weekly, one month experimental period.
Matched group: after clean of every day, apply commercially available cleawhite pack 20～30min before sleeping on facial skin, with warm water cleaning, do not apply other skin care item.2～3 times weekly, one month experimental period.
3 days, 7 days, 1 month each statistics once.
Evaluation criterion: experience by patient's readme, and computer comparison skin texture figure identifies colour of skin whitening degree and mottle desalination degree.Effective: the colour of skin highlights, mottle color dodge.Invalid: before the colour of skin and mottle and experiment, not to be any change.
Result on trial: this product had the whitening effect that is obviously better than commercially available prod in 3 days, effective 42 examples of test group, effective percentage 84%.Effective 16 examples of matched group, effective percentage 32%.Use after 30 days, test group effective percentage reaches 100%, and can also obviously increase the glossiness of skin, and skin exquisiteness is mellow and full.Do not have an example reaction to occur the phenomenons such as irritated, skin is uncomfortable.Matched group is only 56%.
Claims (1)
1. contain the preparation method of the skin-lightening cosmetic of Ramulus Cinnamomi extract, it is characterized in that: the first step: Ramulus Cinnamomi 10 weight portions, Radix Bupleuri 5 weight portions, Fructus Corni 2 weight portions, Flos Rosae Rugosae 2 weight portion mix homogeneously are carried out to 80 orders after pulverizing and sieve, then add the ethanol that 500 weight portion mass concentrations are 85% ~ 90%, soak 24 hours under 25 DEG C of conditions after, carry out low temperature ultrasonic extraction 2 hours, go that supernatant is centrifugal, filtration, backflow ethanol, after secondary filter, obtain Chinese herbal medicine extract; Second step: C18 alcohol 1.5 weight portions, inositol hexaphosphate 0.5 weight portion, glycerol 6 weight portions, stearic acid 12 weight portions are heated to, after 75 DEG C ~ 85 DEG C consolutes, add tertiarybutylhydroquinone 0.02 weight portion, obtain oil phase after dissolving; The 3rd step: add Borax 3 weight portions, glycerol single-hard ester acid ester 2 weight portions, Purified Water 60 weight portions to obtain water after mixing described Chinese herbal medicine extract 3 weight portions; The 4th step: described oil phase is added to emulsifying in the described water of 70 DEG C, add essence in the time that temperature is down to 40 DEG C ~ 50 DEG C, there are the cosmetics of whitening effect described in obtaining.
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| CN112545941A (en) * | 2020-12-17 | 2021-03-26 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with whitening, anti-inflammatory and anti-aging functions and preparation method and application thereof |
| CN112869159A (en) * | 2021-02-04 | 2021-06-01 | 建昌帮药业有限公司 | Anti-wrinkle health product containing folic acid |
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| CN1691930A (en) * | 2001-06-27 | 2005-11-02 | 久光制药株式会社 | Sheet-type packs |
| CN101653409A (en) * | 2009-09-11 | 2010-02-24 | 广州中医药大学 | Whitening and spot eliminating cream and preparation method thereof |
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