CN102836341B - Medicinal granule with whitening effect and preparation method thereof - Google Patents
Medicinal granule with whitening effect and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicinal granule with a whitening effect and a preparation method thereof. The medicinal granule comprises the following raw materials in parts by weight: 70-90 parts of white paeony root, 9-15 parts of rose, 7-15 parts of Chinese honeylocust spine, 30-50 parts of divaricate saposhnikovia root, 60-90 parts of sealwort, 20-30 parts of liquoric root, 70-90 parts of mulberry, 20-60 parts of ginseng flower, 10-50 parts of heterophylly falsestarwort root, 40-90 parts of spina date seed, 10-15 parts of fruit of rosa davurica pall extract, 10-50 parts of vitamin C, 10-50 parts of vitamin E, 20-30 parts of arbutin, 20-40 parts of grape seed extract and 10-30 parts of auxiliary materials. Due to the adoption of the medicinal granule, the defects of external whitening products are overcome, and the growth of melanin is inhibited radically; moreover, unique Chinese medicinal materials are selected, raw materials are combined in a compatible way, and active ingredients such as vitamins and the like are adopted, so that a good synergic action is achieved; and the medicinal granule has good mouthfeel, the problem of poor mouthfeel of the conventional health-care beverage is solved, and the aim of whitening through the medicinal granule in daily life is fulfilled.
Description
Technical field
The present invention relates to a kind of electuary and preparation method thereof, be specifically related to a kind of electuary and preparation method with white-skinned face function.
Background technology
Healthy pale skin is liked pursuing by Aisan, and skin histology is people's ground floor protective barrier, and broad sense is divided into three parts: epidermis, corium and subcutaneous tissue.The color of skin is mainly according to Skin Cell, to contain melanic quantity, size and distribute to determine.For skin-whitening, need to do from cell whitening.For intracellular whitening, first we should stop melanin synthetic, many for the research of restraint of tyrosinase activity on the one hand at this.Tryrosinase is a kind of polyphenol enzyme, belongs to redox enzymes, and this enzyme can catalytic tyrosine be oxidized into DOPA and DOPA quinone and generate 5,6-dihydroxy indole carboxylic acid by dopachrome, generates melanin.Because this enzyme when catalytic reaction, must have bivalent cupric ion and have the participation of oxygen-derived free radicals, so remove, there are oxygen-derived free radicals or complex copper ion can make tryrosinase lose activity, cannot synthesis of melanin.In conjunction with the activity problems of tryrosinase, mainly from two Study of ways, the one, the damage type of tryrosinase suppresses, and can directly to the active site of tryrosinase, modify, and the problem of modification, makes tryrosinase lose the effect to melanocyte precursor-tyrosine; The 2nd, the non-damage type of tryrosinase suppresses, and by the biosynthesis of restraint of tyrosinase or by being at war with substrate tyrosine, thereby reaches the formation of check melanin.Secondly should stop melanic transmission.The process that some material can check melanin granule shifts from melanocyte to horn cell.Finally, should accelerate melanic metabolism.After melanin granule is synthetic; can be reduced on the one hand; make the oxidation state melanin granule reduction of black become white reproducibility melanin granule, secondly, the melanin granule being transferred in skin corium is mainly the lysosome by cell; by with lysosome in some enzyme have an effect; final catabolism falls, so, by adding, can produce lysosomal material by irritation cell; shorten the cutin metabolism cycle, thereby accelerate cuticular coming off.For the cell-melanocyte effect that produces melanin granule, suppress its activity in addition, also can reach the object that obvious check melanin produces.As suppressing melanocytic growth, propagation all can play the effect that check melanin generates.
Present whitening product mainly be take external as main, although the whitening product of external can be eliminated surperficial melanin, but because whitening composition is penetrated into skin internal layer, effectively check melanin does not regrow, so after a period of time, mottle there will be again.How can thoroughly solve easily whitening problem in daily life, be a lot of women's pursuit.For this demand, we have developed the electuary with white-skinned face function, this electuary merges Chinese medicine and vitamin, Semen Vitis viniferae extract isoreactivity material, this two large class whitening composition has advantage separately, by merging, from multipath, bring into play its function, thereby the formation of check melanin, reaches the effect of whitening; And the selected Chinese medicine of electuary can not only be realized whitening, and by compatibility, can realize delay skin aging, effective, mouthfeel is good, has overcome the poor shortcoming of a lot of instant particles as Chinese medicine mouthfeels, has realized women and by electuary, has realized in daily life the object of whitening.
Summary of the invention
The object of this invention is to provide a kind of electuary with white-skinned face function and preparation method thereof.
The object of the invention is to be achieved through the following technical solutions:
An electuary with white-skinned face function, comprises the raw material of following weight portion: Radix Paeoniae Alba 70-90, Flos Rosae Rugosae 9-15, Spina Gleditsiae 7-15, Radix Saposhnikoviae 30-50, Rhizoma Polygonati 60-90, Radix Glycyrrhizae 20-30, Fructus Mori 70-90, Flos Ginseng 20-60, Radix Pseudostellariae 10-50, Semen Ziziphi Spinosae 40-90, rose hip extractum 10-15, vitamin C 10-50, vitamin e1 0-50, arbutin 20-30, Semen Vitis viniferae extract 20-40, adjuvant 10-30.
Adjuvant of the present invention is comprised of the raw material of following weight parts: sucrose 20-40, starch 10-60, dextrin 20-70.
The method of the electuary with white-skinned face function described in manufacture claim 1, comprises the following steps:
1) Radix Paeoniae Alba, Flos Rosae Rugosae, Spina Gleditsiae, Radix Saposhnikoviae, Rhizoma Polygonati, Radix Glycyrrhizae, Flos Ginseng, Radix Pseudostellariae are extracted to twice, the 40% ethanol extraction 1-2 hour that adds for the first time crude drug 7-8 doubly to measure, filters, and obtains filtrate; The water extraction 1-3 hour that adds for the second time crude drug 8-9 doubly to measure, filters, and obtains filtrate; Merge filtrate twice, filter, concentrated, dry, obtain extract;
2) by Semen Ziziphi Spinosae, Fructus Mori cleaning, drying, be ground into fine powder, cross 100 mesh sieves;
3) fine powder of the extract of step 1, step 2 is added to rose hip extractum, vitamin C, vitamin E, arbutin, Semen Vitis viniferae extract, adjuvant mix homogeneously, sterilizing, granulation electuary.
In order to reach better effect, raw material of the present invention can also have Semen Coicis 40-60 part.
The preparation method that is added with the electuary of Semen Coicis raw material, comprises the following steps:
1) Radix Paeoniae Alba, Flos Rosae Rugosae, Spina Gleditsiae, Radix Saposhnikoviae, Rhizoma Polygonati, Radix Glycyrrhizae, Flos Ginseng, Radix Pseudostellariae are extracted to twice, the 40% ethanol extraction 1-2 hour that adds for the first time crude drug 7-8 doubly to measure, filters, and obtains filtrate; The water extraction 1-3 hour that adds for the second time crude drug 8-9 doubly to measure, filters, and obtains filtrate; Merge filtrate twice, filter, concentrated, dry, obtain extract;
2) by Semen Ziziphi Spinosae, Fructus Mori clean dry, be ground into fine powder, cross 100 mesh sieves;
3) Semen Coicis is pulverized, crossed 50 mesh sieves, adopt bulking process ripening;
4) fine powder of the extract of step 1, step 2 and 3 is added to rose hip extractum, vitamin C, vitamin E, arbutin, Semen Vitis viniferae extract, adjuvant mix homogeneously, sterilizing, granulation electuary.
The characteristic and the function that for raw material of the present invention, have are:
The Radix Paeoniae Alba: meridian distribution of property and flavor: the Radix Paeoniae Alba is bitter, sour, is slightly cold, and returns liver, spleen channel, health-care effect: the yin fluid astringing of enriching blood, easing the affected liver relieves the pain, pancake liver-yang, health-care.
Flos Rosae Rugosae: promoting the circulation of QI, promoting the circulation of blood, control migratory arthralgia, loose tired pain relieving, can remove free radical effectively, eliminates pigmentation.
Flos Ginseng: contain 20 kinds of Saponin active substances, 17 seed amino acids, 11 kinds of trace element, three kinds of active anticancer selenium and crude protein etc.Have benefiting QI for activating blood circulation, endocrine regulation, enhances metabolism, and has heart tonifying the kidney invigorating, promoting the production of body fluid to quench thirst, and tonifying kidney and promoting digestion, the increasing intelligence of calming the nerves, and can suppress skin aging.
Radix Saposhnikoviae: inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.
Spina Gleditsiae: draw out pus by applying a plaster to the affected part and dispel the wind, pungent energy is loose, energy promoting the circulation of blood circulation of qi promoting, becomes energy hard masses softening and resolving, and temperature can be searched wind.
Semen Ziziphi Spinosae: be the dry mature seed of Rhamnaceae plant Ziziphi Spinosae, sweet in the mouth, property is flat.Function mind tranquilizing and the heart calming, nourishing the liver arresting sweating, modern pharmacological research shows, Semen Ziziphi Spinosae has anti-aging effects.
Rhizoma Polygonati: be the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati, Rhizoma Polygonati or Polygonatum cyrtonema Hua, sweet in the mouth, property is flat.Function nourishing YIN and moistening the lung, invigorating the spleen and replenishing QI, Zishen fill fine, modern pharmacological research shows to have anti-aging effects.
Fructus Mori: be the dry fruit ear of moraceae plants Mulberry, sweet in the mouth, acid, cold in nature.Function nourishing YIN and benefiting blood, promote the production of body fluid, intestine moistening.
Rose hip: containing multivitamin, there is defying age, resisting fatigue, radioprotective and improve the effects such as immunity.
Radix Pseudostellariae: replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.
Vitamin E in the present invention is a kind of antioxidant, can remove interior free yl, reduces wrinkle of skin, the fitness that retains youth, and the vitamin C in the present invention, can do with uv damage, and vat black pigment accelerates pigementation and discharge effect.
Arbutin, can effectively suppress human tyrosinase enzymatic activity and get rid of free oxygen free radical, block melanic formation, by self and the direct combination of cheese ammonia enzyme, accelerate melanic decomposition and excretion, thereby reduce Skin pigmentation, dispelling stain and freckle, and melanocyte is not produced to the side effect such as toxic, zest, sensitization, also have the effect of sterilization, antiinflammatory simultaneously.
Semen Vitis viniferae extract: remove free radical, defying age, enhancing immunity, antioxidation, desalination mottle.
Semen Coicis is splendid beauty treatment food materials, has the looks improving and the skin nourishing effects such as the flat pox of the wart of controlling, light speckles, beautification and white, skin moistening reduce wrinkle, and especially contained abundant protein amylase can make skin keratin softening.
Drug matching of the present invention can be removed interior free yl, antioxidant effect is good, play delay skin aging, the effect of skin whitening, and the vitamin C in the present invention, vitamin E, arbutin, Semen Vitis viniferae extract isoreactivity substance vat black pigment, accelerates pigementation and discharge effect, also play whitening function
Compared with prior art, beneficial effect of the present invention is embodied in:
1) overcome the defect of the whitening product of external.Although the whitening product of external can be eliminated surperficial melanin, because whitening composition is penetrated into skin internal layer, effectively check melanin does not regrow, so the problem that after a period of time, mottle there will be again.
2) the Chinese medicine selection that the present invention selects is unique, by material combination, produces good synergism; And Chinese medicine is combined with vitamin C, vitamin E, arbutin, Semen Vitis viniferae extract, the activity that has not only suppressed the tryrosinase in skin, block melanic formation, by self and the direct combination of cheese ammonia enzyme, accelerate melanic decomposition and excretion, thereby minimizing Skin pigmentation, can remove pigmented spots, chloasma, freckle, senile plaque.
3) mouthfeel of the present invention is good, has overcome the poor problem of Traditional health care beverage mouthfeel, and has very effectively realized whitening, has realized and by electuary, has easily realized in daily life the object of whitening.
4) product of the present invention are natural product, and human-body safety, avirulence are also had no side effect.
Compared with prior art advantage of the present invention is: product has the effect of antioxidation, looks improving and the skin nourishing, whitening and speckle dispelling, skin moistening relieving restlessness, the nerves calming, is applicable to dim complexion, face skin sore, has the women of freckle, chloasma etc.
In order to verify the effect of whitening and speckle dispelling of the present invention, to 87 ages, at 30-60, the women between year has done the observation of system.
Instructions of taking: select this electuary as being subject to test preparation, each 30 grams, twice of every day.Viewing duration, experimenter need keep reasonable diet structure and work rest program.
Observing time: 30 days.
Feedback result: after 30 days, 87 tested women have 81 female skins smooth, moist, and freckle and chloasma are thin out, and effective percentage reaches 93%.
The specific embodiment
Embodiment mono-:
Prepare by weight following raw material
The Radix Paeoniae Alba 70, Flos Rosae Rugosae 10, Spina Gleditsiae 75, Radix Saposhnikoviae 30, Rhizoma Polygonati 60, Radix Glycyrrhizae 20, Fructus Mori 70, Flos Ginseng 20, Radix Pseudostellariae 30, Semen Ziziphi Spinosae 60, rose hip extractum 10, Catergen 0, vitamin e1 0, arbutin 20, Semen Vitis viniferae extract 20, adjuvant 30.
Its preparation method comprises the following steps:
1) Radix Paeoniae Alba, Flos Rosae Rugosae, Spina Gleditsiae, Radix Saposhnikoviae, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Mori, Flos Ginseng, Radix Pseudostellariae are extracted to twice, add for the first time 40% ethanol extraction 1 hour of 7 times of amounts of crude drug, filter, obtain filtrate; The water extraction 1 hour that adds for the second time 8 times of amounts of crude drug, filters, and obtains filtrate; Merge filtrate twice, 100 orders filter, and adopting vacuum-concentrcted to relative density is 0.9, dry with spray dryer spraying, 185 ℃ of spray dryer inlet temperature, and 120 ℃ of leaving air temps, obtain extract.
2) Semen Ziziphi Spinosae, Fructus Mori are washed, at 60 ℃, dry, pulverize into fine powder, cross 100 mesh sieves.
3) fine powder of the extract of step 1 and step 2 is added to rose hip extractum, vitamin C, vitamin E, arbutin, Semen Vitis viniferae extract, sucrose, starch, dextrin mix homogeneously, with autoclaving sterilizing 30 minutes at 115 ℃.
4) mixture after sterilizing being selected to 85% ethanol with facility for granulating is that binding agent is made powdery granule, with drying equipment, at 65 ℃, be dried to water content 4%, granule is crossed 40 mesh sieves, with mixer, mix, with powder automatic packaging machine, pack, 30 grams one bag, in each packaging bag, contain deoxidizer portion.
Embodiment bis-:
Prepare by weight following raw material:
The Radix Paeoniae Alba 80, Flos Rosae Rugosae 12, Spina Gleditsiae 12, Radix Saposhnikoviae 38, Rhizoma Polygonati 70, Radix Glycyrrhizae 30, Fructus Mori 90, Flos Ginseng 30, Radix Pseudostellariae 30, Semen Ziziphi Spinosae 50, rose hip extractum 15, vitamin C 30, vitamin E 35, arbutin 30, Semen Vitis viniferae extract 20, adjuvant 20.
Its preparation method comprises the following steps:
1) Radix Paeoniae Alba, Flos Rosae Rugosae, Spina Gleditsiae, Radix Saposhnikoviae, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Mori, Flos Ginseng, Radix Pseudostellariae are extracted to twice, add for the first time 40% ethanol extraction 1.5 hours of 8 times of amounts of crude drug, filter, obtain filtrate; The water extraction 2 hours that adds for the second time 8 times of amounts of crude drug, filters, and obtains filtrate; Merge filtrate twice, 100 orders filter, and adopting vacuum-concentrcted to relative density is 1.1, dry with spray dryer spraying, 185 ℃ of spray dryer inlet temperature, and 110 ℃ of leaving air temps, obtain extract.
2) Semen Ziziphi Spinosae, Fructus Mori are washed, at 50 ℃, dry, pulverize into fine powder, cross 100 mesh sieves;
3) fine powder of the extract of step 1 and step 2 is added to rose hip extractum, vitamin C, vitamin E, arbutin, Semen Vitis viniferae extract, sucrose, starch, dextrin mix homogeneously, with autoclaving 115 ℃, lower sterilizing 40 minutes.
4) mixture after sterilizing being selected to 85% ethanol with facility for granulating is that binding agent is made powdery granule, with drying equipment, at 70 ℃, is dried to water content 4%, and granule is crossed 40 mesh sieves, with mixer, mix, 30 grams one bag, pack, contains deoxidizer portion in each packaging bag.
Embodiment tri-:
Prepare by weight following raw material
The Radix Paeoniae Alba 90, Flos Rosae Rugosae 15, Spina Gleditsiae 15, Radix Saposhnikoviae 50, Rhizoma Polygonati 90, Radix Glycyrrhizae 30, Fructus Mori 90, Flos Ginseng 60, Radix Pseudostellariae 50, Semen Ziziphi Spinosae 90, rose hip extractum 15, vitamin C 40, vitamin E 40, arbutin 30, Semen Vitis viniferae extract 40, adjuvant 30.
Its preparation method comprises the following steps:
1) Radix Paeoniae Alba, Flos Rosae Rugosae, Spina Gleditsiae, Radix Saposhnikoviae, Rhizoma Polygonati, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Mori, Flos Ginseng, Radix Pseudostellariae are extracted to twice, add for the first time 40% ethanol extraction 2 hours of 8 times of amounts of crude drug, filter, obtain filtrate; The water extraction 3 hours that adds for the second time 9 times of amounts of crude drug, filters, and obtains filtrate; Merge filtrate twice, 100 orders filter, and adopting vacuum-concentrcted to relative density is 1.2, dry with spray dryer spraying, 195 ℃ of spray dryer inlet temperature, and 120 ℃ of leaving air temps, obtain extract.
2) Semen Ziziphi Spinosae, Fructus Mori are washed, at 60 ℃, dry, pulverize into fine powder, cross 100 mesh sieves.
3) Semen Coicis was pulverized to 50 mesh sieves, adopted bulking process ripening.
4) fine powder of the extract of step 1, step 2 and 3 is added to rose hip extractum, vitamin C, vitamin E, arbutin, Semen Vitis viniferae extract, sucrose, starch, dextrin mix homogeneously, with autoclaving sterilizing 40 minutes at 125 ℃.
5) mixture after sterilizing being selected to 85% ethanol with facility for granulating is that binding agent is made powdery granule, with drying equipment, at 65 ℃, is dried to water content 4%, and granule is crossed 40 mesh sieves, with mixer, mix, 30 grams one bag, pack, contains deoxidizer portion in each packaging bag.
The above; be only the present invention's specific embodiment preferably, but protection scope of the present invention is not limited to this, is anyly familiar with in technical scope that those skilled in the art disclose in the present invention; the variation that can expect easily or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (5)
1. an electuary with white-skinned face function, is characterized in that comprising the raw material of following weight portion: Radix Paeoniae Alba 70-90, Flos Rosae Rugosae 9-15, Spina Gleditsiae 7-15, Radix Saposhnikoviae 30-50, Rhizoma Polygonati 60-90, Radix Glycyrrhizae 20-30, Fructus Mori 70-90, Flos Ginseng 20-60, Radix Pseudostellariae 10-50, Semen Ziziphi Spinosae 40-90, rose hip extractum 10-15, vitamin C 10-50, vitamin e1 0-50, arbutin 20-30, Semen Vitis viniferae extract 20-40, adjuvant 10-30.
2. electuary according to claim 1, is characterized in that described adjuvant comprises the raw material of following weight parts: sucrose 20-40, starch 10-60, dextrin 20-70.
3. a method of manufacturing the electuary described in claim 1 or 2, is characterized in that comprising the following steps:
1) Radix Paeoniae Alba, Flos Rosae Rugosae, Spina Gleditsiae, Radix Saposhnikoviae, Rhizoma Polygonati, Radix Glycyrrhizae, Flos Ginseng, Radix Pseudostellariae are extracted to twice, the 40% ethanol extraction 1-2 hour that adds for the first time crude drug 7-8 doubly to measure, filters, and obtains filtrate; The water extraction 1-3 hour that adds for the second time crude drug 8-9 doubly to measure, filters, and obtains filtrate; Merge filtrate twice, filter, concentrated, dry, obtain extract;
2) by Semen Ziziphi Spinosae, Fructus Mori cleaning, drying, be ground into fine powder, cross 100 mesh sieves;
3) fine powder of the extract of step 1, step 2 is added to rose hip extractum, vitamin C, vitamin E, arbutin, Semen Vitis viniferae extract, adjuvant mix homogeneously, sterilizing, granulation electuary.
4. electuary according to claim 1 and 2, is characterized in that its Raw also has Semen Coicis 40-60 part.
5. the preparation method of electuary claimed in claim 4, is characterized in that comprising the following steps:
1) Radix Paeoniae Alba, Flos Rosae Rugosae, Spina Gleditsiae, Radix Saposhnikoviae, Rhizoma Polygonati, Radix Glycyrrhizae, Flos Ginseng, Radix Pseudostellariae are extracted to twice, the 40% ethanol extraction 1-2 hour that adds for the first time crude drug 7-8 doubly to measure, filters, and obtains filtrate; The water extraction 1-3 hour that adds for the second time crude drug 8-9 doubly to measure, filters, and obtains filtrate; Merge filtrate twice, filter, concentrated, dry, obtain extract;
2) by Semen Ziziphi Spinosae, Fructus Mori clean dry, be ground into fine powder, cross 100 mesh sieves;
3) Semen Coicis is pulverized, crossed 50 mesh sieves, adopt bulking process ripening;
4) fine powder of the extract of step 1, step 2 and 3 is added to rose hip extractum, vitamin C, vitamin E, arbutin, Semen Vitis viniferae extract, adjuvant mix homogeneously, sterilizing, granulation electuary.
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CN104721399A (en) * | 2015-04-07 | 2015-06-24 | 董秀梅 | Traditional Chinese medicine ointment for removing postpartum freckles and preparation method thereof |
CN104886593A (en) | 2015-06-02 | 2015-09-09 | 无限极(中国)有限公司 | A skin whitening compound and an application thereof |
CN104957500A (en) * | 2015-07-01 | 2015-10-07 | 安徽秋果食品有限公司 | Coarse cereal vitamin functional electuary and preparation method thereof |
CN105831750A (en) * | 2016-04-15 | 2016-08-10 | 杨胜 | Nutritive soluble granules having function of whitening and beautifying skin |
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CN102648955A (en) * | 2012-05-03 | 2012-08-29 | 李春仪 | Skin whitening and freckle removing beautifying prescription |
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