CN103565730A - Scented tea whitening skin-moistening cream and preparation method thereof - Google Patents

Scented tea whitening skin-moistening cream and preparation method thereof Download PDF

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CN103565730A
CN103565730A CN201310569535.6A CN201310569535A CN103565730A CN 103565730 A CN103565730 A CN 103565730A CN 201310569535 A CN201310569535 A CN 201310569535A CN 103565730 A CN103565730 A CN 103565730A
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whitening
scented tea
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skin
oil
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CN103565730B (en
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刘丽君
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ZHENGZHOU JIABEILI BIOLOGICAL SCIENCE & TECHNOLOGY Co Ltd
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Abstract

The invention discloses a scented tea whitening skin-moistening cream and a preparation method thereof. The scented tea whitening skin-moistening cream comprises a plurality of traditional Chinese medicine whitening components, a plurality of biochemical whitening components, whitening and protective components extracted from scented tea and green tea, and base raw materials. The whitening and protective components of traditional Chinese medicines and scented tea are self-prepared from licorice root, bletilla striata, bighead atractylodes rhizome, white poria cocos, Japanese ampelopsis root, white peony root, rose, peony and wintersweet flower. The biochemical whitening components comprise purchased ascorbyl tetraisopalmitate and an amino acid whitening agent. The base raw materials comprise a hexadecanol-octadecanol mixture, jojoba oil, an amino acid moisture-retention agent, fucoidin, a cetyl alcohol-octadecyl alcohol mixture and a cetyl glucoside-octadecyl glucoside mixture. Through uniform blending and scientific composition of the whitening and oxidation-resistant components and the moisture-retention and skin-care base raw materials, the scented tea whitening skin-moistening cream is a novel, safe and reliable scented tea whitening skin-moistening cream product having lasting effects.

Description

A kind of scented tea body whitening crème and manufacture method thereof
Technical field
The present invention relates to a kind of body whitening crème and manufacture method thereof that contains scented tea green tea composition, belong to cosmetics and skincare product technical field.
Background technology
Along with social development and the raising of living standard, people more and more pay attention to the beauty of appearance outward appearance.Can cause some women that like to be beautiful due to the impact of all factors, be difficult to have white-skinned skin, the appearance that water is tender.Cause the reason of this intensely dark dry hydropenia skin quality a lot, as geneogenous inherited genetic factors, subhealth state factor posteriority, disease factor, dietary factor, environmental factors etc.Especially for the women who enters person in middle and old age's age bracket, the accumulation of various vivo and vitro problems, more easily in face, embody gloomy unglazed, the situation of shriveling hydropenia.Therefore in the Chinese society of believing in " a white screening hundred is ugly ", women's healthy whitening problem is a cosmetic problem receiving much attention always.But for a long time, due to whitening phychology anxious for success and eager for instant success and quick profits product design, make many whitening class skin care item move towards serious mistaken ideas, major embodiment in the following areas: (one) be take to pursue and is bleached fast as object, departed from gradually the track of self-sow rule and scientific law; (2) take and damage skin health as cost, to obtain temporary transient whiteness of skin; (3) whitening product that toxic and side effects is larger allows skin produce dependency more, and is absorbed in vicious cycle state.Especially the whitening class skin care item that specialized beauty parlors is used, have for eager for instant success and quick profits object, the use of not stinting can cause the poisoning mercurial of accumulation property (being heavy metal) and cause the hormones of skin dependence as additive, and this is the mistaken ideas of having moved towards infringement skin.For skin whitening, paying the impaired cost of skin long-term poisoning, is unworthy really.Therefore in recent years, safety whitening and skin-protecting product is familiar with and accepts by farsighted women gradually, but skin-whitening is a complicated system engineering, influence factor is a lot, although some Skin whitening care cosmeticses are safe and reliable, but slow or invalid to some crowds owing to taking effect, finally cause product without market, this situation is also worthless.As can be seen here, how choose reasonable and science collocation whitening and skin-protecting raw material and additive under the major premise that guarantees product safety, make not only safety but also effective of final products, and this is by the developing direction that is current and following whitening class skin care item.
Traditional safety whitening and skin-protecting product, some effects are slow, and what have is invalid.Or effective while bringing into use, after life-time service, effect declines.Trace it to its cause, may have following aspect: (one) whitening composition is more single, the person that suits the medicine to the illness uses effectively, and the person that do not suit the medicine to the illness is invalid.(2) impact of other factors declines product effect.(3) skin produces " resistance " after to certain whitening agent of life-time service.Visible, in traditional whitening and skin-protecting product, adopt the mentality of designing of single whitening agent, there is many defectives.As " controlling all kinds of diseases and ailments with a medicine ", obviously cannot tackle complicated mechanism, " the melanin formation engineering " that influence factor is numerous, the effect of skin whitening is also difficult to permanent and satisfactory.
The present invention is directed to the defect of current whitening and skin-protecting product and the complexity feature of dermal melanin forming process, strive seeking breakthrough aspect the equilibrium collocation of white-skinned face function raw material and Synergistic.Guaranteeing under the prerequisite of safety first, whitening in whitening composition in whitening composition in Chinese medicine, biogenetic products, teas product and synergistic component etc. are organically combined, reach comprehensive, multipath and tackle melanic product design, to reaching to greatest extent whitening skin and preserving moisture effect safely and effectively.
Summary of the invention
In numerous whitening and skin-protecting raw materials, derive from the whitening composition of plant (as Chinese herbal medicine etc.) extract, there is the permanent effect of safe slow more; And biochemical synthetic whitening composition has high, the effective fast feature of concentration; In the extract of the teas such as green tea, scented tea product, contain multiple whitening composition and protectiveness composition.Use the whitening and skin-protecting composition in multiple source, deal with the gloomy problem of skin, can reach and learn from other's strong points to offset one's weaknesses, the whitening skin and preserving moisture effect of Synergistic.Therefore primary and foremost purpose of the present invention be provide a kind of by the collocation of multiple whitening and skin-protecting balanced composition, Synergistic, effect for a long time, scented tea body whitening crème safely and effectively.To reach to the intensely dark problem of numerous female skins effectively to controlling, the effect of the lasting whitening and softening skin that secures good health.Another object of the present invention is to provide the preparation method of above-mentioned plant (being Chinese herbal medicine), scented tea extract and the preparation method of final scented tea body whitening crème.
For achieving the above object, the technical solution used in the present invention is as follows:
Scented tea body whitening crème of the present invention, is prepared from by following component:
(1) oil phase component: described oil phase component is comprised of the component of following mass parts: 16 mixed alcohol 1-1.5 parts, 16 stearyl alcohol and 16 octadecyl glucoside 2-4 parts, tristerin (with) PEG-100 stearate 1-3 part, iso-octyl palmitate 2-4 part, Jojoba oil 2-4 part, Semen Tritici aestivi germ oil 1-2 part, white oil 2-4 part, Camellia oil 0.5-1 part, dimethicone 2-4 part, methyl hydroxybenzoate 0.2-0.3 part, propylparaben 0.1-0.15 part, ditertbutylparacresol 0.03-0.05 part, biochemical whitening agent Ascorbyl Tetraisopalmitate 2-3 part, 0.5 part of VE oil,
(2) water component: glycerol 5-8 part, amino acid humectant 2-3 part, Sargassum rock polysaccharide 2-4 part, amine acid whitening agent 1-2 part, green tea extractive liquor 1-2 part, Chinese medicine scented tea magistery extracting solution 59-62 part; The raw material that described Chinese medicine scented tea magistery extracting solution is mainly following mass parts is made: Radix Glycyrrhizae 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part, Radix Paeoniae Alba 5-10 part, Poria 5-10 part, Radix Ampelopsis 5-10 part, Flos Rosae Rugosae 3-5 part, Flos Moutan 3-5 part, Flos Mume 3-5 part;
(3) co-emulsifier: ethoxy acrylates/sodium acryloyldimethyl taurate copolymers 0.3-0.5 part;
(4) antiseptic: mixture 0.1-0.15 part of MIT and butyl carbamic acid-3-iodo-2-propynyl ester and propylene glycol;
(5) essence: floral perfume 0.01-0.02 part;
The preparation method of scented tea body whitening crème of the present invention, comprises the steps:
(1) preparation of oil phase part: by 16 mixed alcohols of formula ratio, 16 stearyl alcohol and 16 octadecyl glucosides, tristerin (with) PEG-100 stearate, iso-octyl palmitate, Jojoba oil, Semen Tritici aestivi germ oil, white oil, Camellia oil, dimethicone, methyl hydroxybenzoate, propylparaben, ditertbutylparacresol, after taking in proportion, add with in the rustless steel still stirring, under the stirring of 20-30 revs/min of rotating speeds, heating for dissolving is complete, and at 75-80 ℃ of temperature constant temperature disinfection 20 minutes, the VE oil and the biochemical whitening agent Ascorbyl Tetraisopalmitate that before emulsifying, add formula ratio, stir, stand-by,
(2) preparation of aqueous portion: by the glycerol of formula ratio, amino acid humectant, Sargassum rock polysaccharide, amine acid whitening agent, green tea extractive liquor, Chinese medicine scented tea magistery extracting solution, after taking in proportion, elder generation's heating for dissolving in stainless steel cask, be extracted into afterwards in (passing through filter screen) rustless steel homogenizing still, under the stirring of 20-30 revs/min, continue to be heated to 75--80 ℃, and constant temperature disinfection 20 minutes, stand-by;
(3) by oil phase slowly in suction water, and scrape wall and stir, rotating speed is increased to 40-50 revs/min, stirs after 2-3 minutes, starts high speed homogenization device, under the high speed of 3000-5000 revs/min, homogenizing is 3-5 minutes, to scrape afterwards wall rotating speed and drop to 30-40 revs/min, and be cooled to 40 ℃ under this rotating speed, add co-emulsifier, antiseptic, the essence of formula ratio, continuation is stirred 15-20 minutes under same rotating speed, gets final product discharging.
Described Chinese medicine scented tea magistery extracting solution prepares by the following method:
(1) take dry product Radix Glycyrrhizae 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part, Radix Paeoniae Alba 5-10 part, Poria 5-10 part, Radix Ampelopsis 5-10 part, Flos Rosae Rugosae 3-5 part, Flos Moutan 3-5 part, Flos Mume 3-5 part, adds in rustless steel still;
(2) while boiling for the first time, take 800-900 parts of deionized waters, 4-6 parts of ethanol, 4-6 parts of propylene glycol, boil front first immersion 30 minutes, then use big fire boiled, after use little fire instead and boil 1.0-1.2 hours, with 600 order filter-cloth filterings, obtain Chinese medicine scented tea magistery extracting solution 1. afterwards;
(3) in filtering residue, add the propylene glycol of the deionized water of 400-500 mass parts and the ethanol of 1-3 mass parts and 1-3 mass parts, after big fire is boiled, use little fire instead and boil again 0.8-1.0 hours, use afterwards 600 order filter-cloth filterings, obtain Chinese medicine scented tea magistery extracting solution 2.;
(4) will be 1., 2. after filtrate mix homogeneously, obtain final Chinese medicine scented tea magistery extracting solution, its total amount should be controlled at half left and right of adding total Water.
The present invention is directed to current environmental pollution serious, skin sub-health status, the more reality of damage situations even, according to known melanin, form mechanism, add following green tea, scented tea extracting solution, biochemical whitening agent, Chinese medicine whitening composition, skin care moisturizing and become to grade, make there is whitening and softening skin, improve skin quality, the body whitening crème product of preserving moisture and protecting skin effect.
Flos Rosae Rugosae: looks improving and the skin nourishing effect is remarkable, offsets removing freckle, and wrinkle effect is obvious, the resolving depression of regulating the flow of vital energy, promoting blood circulation to remove blood stasis, improves withered skin, blood circulation promoting and metabolism.
Flos Moutan: looks improving and the skin nourishing, functions of removing chloasma, slow down aging, the regulating liver-QI that nourishes blood, loose strongly fragrant blood stasis dispelling, can make that QI and blood is abundant, appearance is ruddy, energetic.
Flos Mume: control chloasma, chloasma hepaticum, skin sore that endocrine regulation causes evident in efficacy, enrich blood, pathogenic fire reducing, strengthening the spleen and stomach, the meridian dredging, antiinflammatory, external makes skin become delicate ruddy.
Green tea extract: green tea is azymic tea, its characteristic has determined that it has more preserved the natural material in fresh leaf.Wherein, tea polyphenols, caffeine have been preserved the more than 85% of fresh leaf, and chlorophyll has been preserved 50% left and right, and vitamin loss is also less, also have lipopolysaccharide, theanine isoreactivity material.Tea polyphenols in green tea has very strong antioxidation, and its oxidation resistance is synthetic antioxidant BHT, BHA 4-6 times, is 6-7 times of vitamin E, is ascorbic 5-10 times.It is the scavenger of human free radical.Studies have shown that 1 milligram of tea polyphenols removing is equivalent to 9 microgram superoxide dismutase to the usefulness of the harmful excessive free radicals of people's human body, is much higher than other allied substances.The effect that tea polyphenols has blocking-up lipid peroxidation, removes organized enzyme, its defying age effect is stronger 18 times than vitamin E.Tea polyphenols is water-soluble substances, with it wash one's face can remove face greasy, convergence pore, has ultraviolet radiation in sterilization, sterilizing, resisting age of skin, minimizing daylight and computer, the injury of TV radiation to skin.Its stronger antioxidation contributes to the stable of other whitening active component in formula.
Biochemical whitening agent ascorbic acid four different Palmic acid acid esters: be the derivant of fat soluble vitamin C, be easily absorbed by the skin also there is good stability, not only can skin whitening, also have similar SOD active, Scavenger of ROS, promote collagen protein synthesis.The mechanism of vitamin C derivatives skin whitening is mainly the intermediate in vat black pigment generative process---DOPA quinone, plays inhibited oxidation chain, reduces the effect that melanin generates.But well-known, the difficult lasting problem of the equal existence and stability of vitamin C derivatives class, is used in conjunction with green tea extract, scented tea extract, VE wet goods, can reach Synergistic and lasting whitening effect.
Amine acid whitening agent: i.e. hydroxyethylamino butanoic acid, its mechanism of action is to accelerate tegumentary chromatophore group's renewal and metabolism, thus slow down that melanin goes to and productive set at epiderm skin, reach the effect of skin whitening.
Radix Glycyrrhizae: be Chinese medicine, interior contained licoflavone has restraint of tyrosinase activity, suppresses the multiple action of dopachrome interconvertible enzyme and DHICA oxidase active, can reach good whitening effect.Remove in addition the effects such as oxygen-derived free radicals, antioxidation.Contained glycyrrhizic acid and glycyrrhetate in Radix Glycyrrhizae, also have the effect of antiinflammatory, antiallergic action.
Poria: sweet in the mouth, light, property be flat, can dispelling speckles and whitening face, moist skin, can also strengthen immunologic function, blood vessel dilating.< < Bencao Pinhui Jingyao > > says: " Poria for end, close honey and, on flush coat, treat the black bleb of acne vulgaris and puerpera, as Ovum passeris ".
The Pseudobulbus Bletillae (Rhizoma Bletillae): materials for skin whiting for removing freckle, astringing to arrest bleeding, detumescence and promoting granulation.It is exactly the good medicine of improving looks that the Pseudobulbus Bletillae (Rhizoma Bletillae) is controlled oneself, and is described as " whitening fairy maiden ", can Acne treatment, the dermatosis such as tinea corporis, cicatrix.< < property of medicine opinion > > cloud: " it can control skin ulcer on face, makes us flesh and slides ".< < Compendium of Materia Medica > > cloud its " black, the speckle dispelling of washing one's face ".
The Radix Paeoniae Alba: sweet in the mouth, acid, cold nature, there is the effect of nourishing blood, can treat shallow complexion, facial colour spot, tarnish.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm.Return spleen, stomach warp.There is air making-up and spleen enlivening, dampness diuretic, hidroschesis, antiabortive effect.Also has whitening and skin-protecting effect.The traditional Chinese medical science thinks, whether people's the happy pool of skin has substantial connection with function, if internal organs pathological changes, disharmony between QI and blood, pachylosis, the raw speckle of face.Three plain soups that Ming Dynasty's (16th century) medical science works < < Elementary Medicine > > records: the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria and Radix Glycyrrhizae are made.From QI and blood regulating, the function of conditioning the five internal organs is started with, thereby reaches the effect of whitening and speckle dispelling,
Radix Ampelopsis: nature and flavor: bitter sweet pungent, cool.< < Bencao Beiyao > > cloud: energy pathogenic fire purging, eliminating stagnation.Hardship can be let out, and pungent energy is loose, Gan Nenghuan, cold energy heat extraction.Kill fire-toxin, eliminating stagnation gas, granulation promoting pain relieving.Control that carbuncle skin ulcer is swollen, skin ulcer, incised wound are flutterred damage on face.
Still not by multiple whitening composition, the wet composition of teas extract, Chinese medicine extract and skin care moisturizing carries out equilibrium collocation in the market, have complementary advantages, and after scientific formula, the not only safety but also efficient scented tea body whitening crème product that develop.
The invention has the beneficial effects as follows: the whitening in the whitening conditioning reason composition in biochemical whitening composition and Chinese medicine and green tea scented tea, antioxidant content etc. are organically combined, and in function, carry out equilibrium and arrange in pairs or groups, learn from other's strong points to offset one's weaknesses, to guarantee being issued to efficient whitening and moistening skin effect in the prerequisite being perfectly safe.As everyone knows, skin-whitening problem, not only complicated mechanism, cycle are longer, and influence factor is numerous.Therefore how more scientific, rationally, enduringly given play to various whitening active matters effect; just certainly exist a balanced collocation; mutually promote and the problem of potentiation protection; the shelf-life of general whitening and moistening skin class cosmetics is 3 years; within so long period; how to keep and strengthen the whitening effect of each whitening active component; the method of the multiple compound protection compositions such as interpolation green tea extract of the present invention, scented tea extract, VE oil and BHT; reached the ideal effect of expection; not only whitening and moistening skin effect is remarkable; and effect is lasting, without any side effects.
The specific embodiment
Embodiment 1
(1) preparation process of special ratios Chinese medicine scented tea magistery extracting solution is as follows:
(1) take 5 parts, dry product Radix Glycyrrhizae, 7.5 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 5 parts of the Radix Paeoniae Albas, 7.5 parts of Porias, 10 parts of Radix Ampelopsis, 5 parts of Flos Rosae Rugosaes, 3 parts of Flos Moutaies, 4 parts of Flos Mume. add in rustless steel still;
(2) while boiling for the first time, take 800 parts of deionized waters, 4 parts of ethanol, 4 parts of propylene glycol, boil front first immersion 30 minutes, then use big fire boiled, after use little fire instead and boil 1.0-1.2 hours, with 600 order filter-cloth filterings, obtain Chinese medicine scented tea magistery extracting solution 1. afterwards.
(3) in filtering residue, add the propylene glycol of the deionized water of 500 mass parts and the ethanol of 3 mass parts and 3 mass parts, after big fire is boiled, use little fire instead and boil again 0.8-1.0 hours, use afterwards 600 order filter-cloth filterings, obtain Chinese medicine scented tea magistery extracting solution 2..
(4) will be 1., 2. after filtrate mix homogeneously, obtain final Chinese medicine magistery extracting solution, its total amount should be controlled at half left and right of adding total Water.
(2) with the Chinese medicine scented tea magistery extracting solution making, substitute the pure water component in scented tea body whitening crème, as follows by the prescription of following proportioning (mass percent) design scented tea body whitening crème:
A: oil phase component: 16 1 part of mixed alcohol, 16 stearyl alcohol and 2 parts of 16 octadecyl glucosides, tristerin (with) 2 parts of PEG-100 stearates, 3 parts of iso-octyl palmitate, 3 parts of Jojoba oils, 1.5 parts of Semen Tritici aestivi germ oils, 3 parts of white oils, 1 part of Camellia oil, 3 parts of dimethicones, 0.2 part of methyl hydroxybenzoate, 0.1 part of propylparaben, 0.03 part of ditertbutylparacresol;
2 parts of 0.5 part of B:VE oil and biochemical whitening agent Ascorbyl Tetraisopalmitate;
C: the preparation of aqueous portion: by 7 parts of glycerol, 3 parts of amino acid humectants, 3 parts of Sargassum rock polysaccharide, 2 parts of amine acid whitening agent, 1.0 parts of green tea extractive liquors, 61.26 parts of Chinese medicine magistery extracting solution;
D: co-emulsifier: 0.3 part of ethoxy acrylates/sodium acryloyldimethyl taurate copolymers;
E: antiseptic: 0.1 part, the mixture of MIT and butyl carbamic acid-3-iodo-2-propynyl ester and propylene glycol;
F: essence: 0.01 part of floral perfume;
(3) preparation process of scented tea body whitening crème is as follows:
(1) with stainless steel cask, take A phase component, after taking in proportion, add with in the rustless steel still stirring, under the stirring of 30 revs/min of rotating speeds, heating for dissolving is complete, and at 80 ℃ of temperature constant temperature disinfection 20 minutes, before emulsifying, add B phase component, stir, stand-by.
(2) with stainless steel cask, take after C phase component heating for dissolving in suction emulsifying kettle, under the stirring of 30 revs/min, continue to be heated to 80 ℃, and constant temperature disinfection 20 minutes, stand-by.
(3) by oil phase A slowly in suction water C, and scrape wall and stir, rotating speed is increased to 50 revs/min, stir after 3 minutes, start high speed homogenization device, under the high speed of 5000 revs/min, homogenizing is 4 minutes, to scrape afterwards wall rotating speed and drop to 30 revs/min, and under this rotating speed, be cooled to 40 ℃.
(4) add D, E, F phase, continue to stir under same rotating speed within 15 minutes, to get final product discharging.
Embodiment 2
(1) preparation process of special ratios Chinese medicine scented tea magistery extracting solution is as follows:
(1) take 7.5 parts, dry product Radix Glycyrrhizae, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 7.5 parts of the Radix Paeoniae Albas, 10 parts of Porias, 5 parts of Radix Ampelopsis, 4 parts of Flos Rosae Rugosaes, 3 parts of Flos Moutaies, 5 parts of Flos Mume. add in rustless steel still;
(2) while boiling for the first time, take 850 parts of deionized waters, 5 parts of ethanol, 5 parts of propylene glycol, boil front first immersion 30 minutes, then use big fire boiled, after use little fire instead and boil 1.0-1.2 hours, with 600 order filter-cloth filterings, obtain Chinese medicine magistery extracting solution 1. afterwards.
(3) in filtering residue, add the propylene glycol of the deionized water of 450 mass parts and the ethanol of 2 mass parts and 2 mass parts, after big fire is boiled, use little fire instead and boil again 0.8-1.0 hours, use afterwards 600 order filter-cloth filterings, obtain Chinese medicine magistery extracting solution 2..
(4) will be 1., 2. after filtrate mix homogeneously, obtain final Chinese medicine scented tea magistery extracting solution, its total amount should be controlled at half left and right of adding total Water.
(2) with the Chinese medicine scented tea magistery extracting solution making, substitute the pure water component in scented tea body whitening crème, as follows by the prescription of following proportioning (mass percent) design scented tea body whitening crème:
A: oil phase component: 16 1.5 parts of mixed alcohols, 16 stearyl alcohol and 3 parts of 16 octadecyl glucosides, tristerin (with) 2 parts of PEG-100 stearates, 2 parts of iso-octyl palmitate, 4 parts of Jojoba oils, 1 part of Semen Tritici aestivi germ oil, 3.5 parts of white oils, 0.5 part of Camellia oil, 3 parts of dimethicones, 0.2 part of methyl hydroxybenzoate, 0.1 part of propylparaben, 0.03 part of ditertbutylparacresol;
3 parts of 0.5 part of B:VE oil and biochemical whitening agent Ascorbyl Tetraisopalmitate;
C: the preparation of aqueous portion: by 8 parts of glycerol, 2.5 parts of amino acid humectants, 2 parts of Sargassum rock polysaccharide, 1 part of amine acid whitening agent, 2 parts of green tea extractive liquors, 59.66 parts of Chinese medicine scented tea magistery extracting solution;
D: co-emulsifier: 0.4 part of ethoxy acrylates/sodium acryloyldimethyl taurate copolymers;
E: antiseptic: 0.1 part, the mixture of MIT and butyl carbamic acid-3-iodo-2-propynyl ester and propylene glycol;
F: essence: 0.01 part of floral perfume.
(3) preparation process of scented tea body whitening crème is as follows:
(1) with stainless steel cask, take A phase component, after taking in proportion, add with in the rustless steel still stirring, under the stirring of 25 revs/min of rotating speeds, heating for dissolving is complete, and at 80 ℃ of temperature constant temperature disinfection 20 minutes, before emulsifying, add B phase component, stir, stand-by.
(2) with stainless steel cask, take after C phase component heating for dissolving in suction emulsifying kettle, under the stirring of 25 revs/min, continue to be heated to 80 ℃, and constant temperature disinfection 20 minutes, stand-by.
(3) by oil phase A slowly in suction water C, and scrape wall and stir, rotating speed is increased to 50 revs/min, stir after 3 minutes, start high speed homogenization device, under the high speed of 4500 revs/min, homogenizing is 5 minutes, to scrape afterwards wall rotating speed and drop to 30 revs/min, and under this rotating speed, be cooled to 40 ℃.
(4) add D, E, F phase, continue to stir under same rotating speed within 20 minutes, to get final product discharging.
Embodiment 3
(1) preparation process of special ratios Chinese medicine scented tea magistery extracting solution is as follows:
(1) take 10 parts, dry product Radix Glycyrrhizae, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 7.5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts of the Radix Paeoniae Albas, 5 parts of Porias, 7.5 parts of Radix Ampelopsis, 3 parts of Flos Rosae Rugosaes, 5 parts of Flos Moutaies, 3 parts of Flos Mume, add in rustless steel still;
(2) while boiling for the first time, take 900 parts of deionized waters, 6 parts of ethanol, 6 parts of propylene glycol, boil front first immersion 30 minutes, then use big fire boiled, after use little fire instead and boil 1.0-1.2 hours, with 600 order filter-cloth filterings, obtain Chinese medicine magistery extracting solution 1. afterwards.
(3) in filtering residue, add the propylene glycol of the deionized water of 400 mass parts and the ethanol of 1 mass parts and 1 mass parts, after big fire is boiled, use little fire instead and boil again 0.8-1.0 hours, use afterwards 600 order filter-cloth filterings, obtain Chinese medicine scented tea magistery extracting solution 2..
(4) will be 1., 2. after filtrate mix homogeneously, obtain final Chinese medicine scented tea magistery extracting solution, its total amount should be controlled at half left and right of adding total Water.
(2) with the Chinese medicine scented tea magistery extracting solution making, substitute the pure water component in scented tea body whitening crème, as follows by the prescription of following proportioning (mass percent) design scented tea body whitening crème:
A: oil phase component: 16 1.2 parts of mixed alcohols, 16 stearyl alcohol and 2.5 parts of 16 octadecyl glucosides, tristerin (with) 2.5 parts of PEG-100 stearates, 2.5 parts of iso-octyl palmitate, 2 parts of Jojoba oils, 2 parts of Semen Tritici aestivi germ oils, 3.5 parts of white oils, 1 part of Camellia oil, 2 parts of dimethicones, 0.2 part of methyl hydroxybenzoate, 0.1 part of propylparaben, 0.03 part of ditertbutylparacresol;
2.5 parts of 0.5 part of B:VE oil and biochemical whitening agent Ascorbyl Tetraisopalmitate;
C: the preparation of aqueous portion: by 6 parts of glycerol, 3 parts of amino acid humectants, 4 parts of Sargassum rock polysaccharide, 1.5 parts of amine acid whitening agent, 1.5 parts of green tea extractive liquors, 61.06 parts of Chinese medicine magistery extracting solution;
D: co-emulsifier: 0.3 part of ethoxy acrylates/sodium acryloyldimethyl taurate copolymers;
E: antiseptic: 0.1 part, the mixture of MIT and butyl carbamic acid-3-iodo-2-propynyl ester and propylene glycol;
F: essence: 0.01 part of floral perfume.
(3) preparation process of scented tea body whitening crème is as follows:
(1) with stainless steel cask, take A phase component, after taking in proportion, add with in the rustless steel still stirring, under the stirring of 30 revs/min of rotating speeds, heating for dissolving is complete, and at 80 ℃ of temperature constant temperature disinfection 20 minutes, before emulsifying, add B phase component, stir, stand-by.
(2) with stainless steel cask, take after C phase component heating for dissolving in suction emulsifying kettle, under the stirring of 30 revs/min, continue to be heated to 80 ℃, and constant temperature disinfection 20 minutes, stand-by.
(3) by oil phase A slowly in suction water C, and scrape wall and stir, rotating speed is increased to 50 revs/min, stir after 3 minutes, start high speed homogenization device, under the high speed of 4800 revs/min, homogenizing is 4 minutes, to scrape afterwards wall rotating speed and drop to 30 revs/min, and under this rotating speed, be cooled to 40 ℃.
(4) add D, E, F phase, continue to stir under same rotating speed within 20 minutes, to get final product discharging.
Effect embodiment:
Detection method:
Melanocyte synthetic test in suppressing in mouse melanin cell.
By B16 mouse melanin tumor cell with 1 * 10 5the density of individual/ml is connected to the culture dish that diameter is 9cm, at 37 ℃ ﹑ 5% CO 2condition under cultivate 2 days, abandon supernatant, add the sample solution 18-22ml after filtration sterilization, then cultivate 3 days, abandon supernatant, PBS washing, every hole adds the pancreatin solution peptic cell 3min of 0.5ml mass percent 0.2%, every ware adds 2ml maintenance medium and stops digestion. after piping and druming mixes, every kind of concentration is taken out 0.5ml and is made cell counting. and all the other cell suspension, with the centrifugal 5min of 2500r/min, are abandoned supernatant, in precipitation, add NaoH solution, heating is dissolved melanin, on the enzyme-linked immunosorbent assay instrument of selection 490nm wavelength, surveys absorbance.
Melanin synthesizes suppression ratio=(1-(medicine hole absorbance+medicine porocyte density)+(control wells absorbance+control wells cell density)) * 100%.
Melanocyte synthetic test in suppressing in mouse melanin cell, result is as shown in table 1
Table 1
? Suppression ratio (%)
Embodiment 1 61.3
Embodiment 2 62.9
Embodiment 3 60.7
Above-mentioned experimental result shows, effectively check melanin generation of scented tea body whitening crème of the present invention, and effect is remarkable.
Above-described embodiment is preferably embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any Gai Bian ﹑ Xiu Shi ﹑ Ti Dai ﹑ Zu He ﹑ doing under spirit of the present invention and principle that do not deviate from simplifies; all should be equivalent substitute mode, within being included in protection scope of the present invention.

Claims (2)

1. a scented tea body whitening crème, is characterized in that being prepared from by following component:
(1) oil phase component: described oil phase component is comprised of the component of following mass parts: 16 mixed alcohol 1-1.5 parts, 16 stearyl alcohol and 16 octadecyl glucoside 2-4 parts, tristerin (with) PEG-100 stearate 1-3 part, iso-octyl palmitate 2-4 part, Jojoba oil 2-4 part, Semen Tritici aestivi germ oil 1-2 part, white oil 2-4 part, Camellia oil 0.5-1 part, dimethicone 2-4 part, methyl hydroxybenzoate 0.2-0.3 part, propylparaben 0.1-0.15 part, ditertbutylparacresol 0.03-0.05 part, biochemical whitening agent Ascorbyl Tetraisopalmitate 2-3 part, 0.5 part of VE oil,
(2) water component: glycerol 5-8 part, amino acid humectant 2-3 part, Sargassum rock polysaccharide 2-4 part, amine acid whitening agent 1-2 part, green tea extractive liquor 1-2 part, Chinese medicine scented tea magistery extracting solution 59-62 part; The raw material that described Chinese medicine scented tea magistery extracting solution is mainly following mass parts is made: Radix Glycyrrhizae 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part, Radix Paeoniae Alba 5-10 part, Poria 5-10 part, Radix Ampelopsis 5-10 part, Flos Rosae Rugosae 3-5 part, Flos Moutan 3-5 part, Flos Mume 3-5 part;
(3) co-emulsifier: ethoxy acrylates/sodium acryloyldimethyl taurate copolymers 0.3-0.5 part;
(4) antiseptic: mixture 0.1-0.15 part of MIT and butyl carbamic acid-3-iodo-2-propynyl ester and propylene glycol;
(5) essence: floral perfume 0.01-0.02 part;
The preparation method of scented tea body whitening crème claimed in claim 1, is characterized in that, comprises the steps:
The preparation of oil phase part: by 16 mixed alcohols of formula ratio, 16 stearyl alcohol and 16 octadecyl glucosides, tristerin (with) PEG-100 stearate, iso-octyl palmitate, Jojoba oil, Semen Tritici aestivi germ oil, white oil, Camellia oil, dimethicone, methyl hydroxybenzoate, propylparaben, ditertbutylparacresol, after taking in proportion, add with in the rustless steel still stirring, under the stirring of 20-30 revs/min of rotating speeds, heating for dissolving is complete, and at 75-80 ℃ of temperature constant temperature disinfection 20 minutes, the VE oil and the biochemical whitening agent Ascorbyl Tetraisopalmitate that before emulsifying, add formula ratio, stir, stand-by,
The preparation of aqueous portion: by the glycerol of formula ratio, amino acid humectant, Sargassum rock polysaccharide, amine acid whitening agent, green tea extractive liquor, Chinese medicine scented tea magistery extracting solution, after taking in proportion, elder generation's heating for dissolving in stainless steel cask, be extracted into afterwards in (passing through filter screen) rustless steel homogenizing still, under the stirring of 20-30 revs/min, continue to be heated to 75--80 ℃, and constant temperature disinfection 20 minutes, stand-by;
By oil phase slowly in suction water, and scrape wall and stir, rotating speed is increased to 40-50 revs/min, stirs after 2-3 minutes, starts high speed homogenization device, under the high speed of 3000-5000 revs/min, homogenizing is 3-5 minutes, to scrape afterwards wall rotating speed and drop to 30-40 revs/min, and be cooled to 40 ℃ under this rotating speed, add co-emulsifier, antiseptic, the essence of formula ratio, continuation is stirred 15-20 minutes under same rotating speed, gets final product discharging.
2. the preparation method of scented tea body whitening crème according to claim 2, is characterized in that described Chinese medicine scented tea magistery extracting solution prepares by the following method:
Take dry product Radix Glycyrrhizae 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part, Radix Paeoniae Alba 5-10 part, Poria 5-10 part, Radix Ampelopsis 5-10 part, Flos Rosae Rugosae 3-5 part, Flos Moutan 3-5 part, Flos Mume 3-5 part, adds in rustless steel still;
While boiling for the first time, take 800-900 parts of deionized waters, 4-6 parts of ethanol, 4-6 parts of propylene glycol, boil front first immersion 30 minutes, then use big fire boiled, after use little fire instead and boil 1.0-1.2 hours, with 600 order filter-cloth filterings, obtain Chinese medicine scented tea magistery extracting solution 1. afterwards;
The propylene glycol that adds the deionized water of 400-500 mass parts and the ethanol of 1-3 mass parts and 1-3 mass parts in filtering residue, after big fire is boiled, use little fire instead and boil again 0.8-1.0 hours, use afterwards 600 order filter-cloth filterings, obtain Chinese medicine scented tea magistery extracting solution 2.;
Will be 1., 2. after filtrate mix homogeneously, obtain final Chinese medicine scented tea magistery extracting solution, its total amount should be controlled at half left and right of adding total Water.
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1947696A (en) * 2005-10-14 2007-04-18 范红 Formula of traditional Chinese medicine with white-skinned face function
CN102302440A (en) * 2011-09-23 2012-01-04 孙丽华 Chinese medicinal herb softening, whitening, anti-aging, wrinkle-smoothing and freckle-removing cosmetic composition
CN102512343A (en) * 2011-12-16 2012-06-27 罗芸 Preparation method for flower and volcanic mud cream
CN103349628A (en) * 2013-06-11 2013-10-16 天津科丝美特生物科技有限公司 Skincare composition with whitening effect

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1947696A (en) * 2005-10-14 2007-04-18 范红 Formula of traditional Chinese medicine with white-skinned face function
CN102302440A (en) * 2011-09-23 2012-01-04 孙丽华 Chinese medicinal herb softening, whitening, anti-aging, wrinkle-smoothing and freckle-removing cosmetic composition
CN102512343A (en) * 2011-12-16 2012-06-27 罗芸 Preparation method for flower and volcanic mud cream
CN103349628A (en) * 2013-06-11 2013-10-16 天津科丝美特生物科技有限公司 Skincare composition with whitening effect

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