CN112168734A - Meal bioactive peptide moisturizer with effect of reducing uric acid - Google Patents
Meal bioactive peptide moisturizer with effect of reducing uric acid Download PDFInfo
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- CN112168734A CN112168734A CN202010860806.3A CN202010860806A CN112168734A CN 112168734 A CN112168734 A CN 112168734A CN 202010860806 A CN202010860806 A CN 202010860806A CN 112168734 A CN112168734 A CN 112168734A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a meal bioactive peptide moisturizer with the effect of reducing uric acid, which comprises the following components in parts by weight: 10-30 parts of almond meal, 10-30 parts of peony, 10-30 parts of white poria, 10-30 parts of glycerol and 10-30 parts of deionized water, and relates to the technical field of cosmetics. The technical scheme has the functions of moisturizing the skin of a user, and can reduce the uric acid content of the user, so that the moisturizing cream has more functions compared with the traditional moisturizing cream.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a meal bioactive peptide moisturizer with a uric acid reducing effect.
Background
Biologically active peptides are generally obtained by degradation of proteins. The bioactive peptide is an intermediate product of degrading protein into amino acid, is a precursor substance of the amino acid, is formed by polymerizing and connecting a plurality of or a plurality of amino acid molecules, and has unique physiological activity and medical care function which are not possessed by the original protein and the monomer amino acid. It is used in food, health food and medical treatment, and has the functions of nourishing, health care and treatment;
the traditional moisturizer has single function, and the almond with the function of reducing uric acid is added into the traditional moisturizer and is used in the moisturizer, so that the use mode of the traditional bioactive peptide is changed.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the meal bioactive peptide moisturizer with the effect of reducing uric acid, and solves the technical problem that the function of the existing moisturizer is single, and almond with the effect of reducing uric acid is added into the traditional moisturizer and is used in the moisturizer, so that the use mode of the traditional bioactive peptide is changed.
In order to achieve the purpose, the invention is realized by the following technical scheme: a meal bioactive peptide moisturizer with the effect of reducing uric acid is characterized by comprising the following components in parts by weight: 10-30 parts of almond meal, 10-30 parts of peony, 10-30 parts of white poria, 10-30 parts of glycerol and 10-30 parts of deionized water.
Step S1: screening and peeling almonds, then adding the almonds into a grinder for grinding to obtain almond powder, and adding the almond powder into a grinder for grinding to obtain fine powder for later use;
step S2, adding water into almond powder to make the mass content of almond meal reach 10-15% (w/w), then heating, and then passing through a colloid mill to obtain almond meal slurry;
step S3: heating the almond pulp slurry to 45-55 ℃, adding alkaline protease and cellulase, inactivating enzyme when the hydrolysis degree reaches 10-15%, centrifuging, and taking supernatant as almond pulp enzymatic hydrolysate; based on the mass of the raw material almond meal, the adding amount of the alkaline protease accounts for 0.6-1.2%, and the adding amount of the cellulase accounts for 1.0-1.5%;
step S4, collecting the permeate of the ultrafiltration membrane of the almond pulp enzymatic hydrolysate, passing through strong acid gel type cation exchange resin, eluting with acidic water as an eluent, and collecting the eluent; and concentrating the eluent in vacuum, and performing spray drying to obtain the bioactive peptide with the effect of reducing uric acid.
Step S5: metering peony, chinaroot greenbrier rhizome, glycerol and deionized water into a mixing tank for mixing, continuously heating to 75-80 ℃ under the stirring of 20-30 r/m, and sterilizing at constant temperature for 20 minutes to obtain a water phase material;
step S6: adding the water phase material into an emulsifying machine, adding the oil phase material into the emulsifying machine for emulsification to obtain an emulsifying agent, and then adding the biological active peptide with the effect of reducing uric acid to obtain a product.
Preferably, in step S2, the heating temperature is 130 degrees celsius, and the heating time is 20 min.
Preferably, the oil phase raw materials in the step S6 are 1% -5% of mixed alcohol, 0.2% -0.8% of vaseline, 0.2% -0.8% of lanolin, and 8% -12% of liquid paraffin.
Preferably, the membrane flux in step S5 is 10000Da ultrafiltration membrane.
Advantageous effects
The invention provides a meal bioactive peptide moisturizer with the effect of reducing uric acid. The moisturizing cream has the following beneficial effects that the moisturizing cream has a moisturizing function for a user, can reduce the uric acid content of the user, and has more functions compared with the traditional moisturizing cream.
Detailed Description
A cake bioactive peptide skin caring cream with uric acid lowering effect is provided.
Uric acid is a metabolic disease caused by the fact that a substance called purine is metabolized and disordered in a human body to cause uric acid increase in blood, the daily production amount and the excretion amount of uric acid in the human body are approximately equal, on the aspect of the production amount, one third of uric acid is produced by food, two thirds of uric acid is synthesized by the human body, the excretion route is one third excretion from intestinal tracts, and two thirds of uric acid is excreted from kidneys.
Example (b): the main raw materials of the technical scheme comprise 10-30 parts of almond meal, 10-30 parts of peony, 10-30 parts of white poria, 10-30 parts of glycerol and 10-30 parts of deionized water.
The almond meal contains 16 amino acids, wherein the content of glutamic acid is the highest (6.91%); essential amino acids account for 42% of total amino acids; the protein content was 42.92%; the total energy is up to 20937kJ/kg, and also contains various nutrient components such as fat, calcium, magnesium and the like;
the variety of the peony cultivators is monotonous, and the flowers are mostly white. Root bark, called moutan bark, moutan bark powder, moutan bark, etc., is a commonly used Chinese medicine for cooling blood and removing stasis;
cortex moutan is slightly cold in nature, bitter and pungent in flavor. It enters heart, liver and kidney meridians. Clear heat and cool blood, activate blood and resolve stasis. Can be used for treating toxic heat, speckle, hematemesis, epistaxis, nocturnal fever, morning coldness, anhidrosis, amenorrhea, dysmenorrhea, carbuncle, swelling, sore, traumatic injury, etc. Modern researches show that the cortex moutan has the activities of resisting bacteria, inflammation, allergy, tumor, bleeding, removing blood stasis, clearing away heat and toxic materials, tranquilizing, relieving pain, relieving spasm, promoting phagocytic function of mononuclear cells, improving specific immunity of organisms, and increasing the weight of immune organs. It should be used with cautions for pregnant women and people with menorrhagia due to blood deficiency with cold. Peony contains astragaloside, and can be used for regulating menstruation and promoting blood circulation;
poria has direct relaxation effect on rabbit isolated intestinal canal, and can be used for preventing ulcer formed by rat pylorus ligation and reducing gastric acid. In addition, the compound has obvious protection effect on rat liver injury caused by CCl4, so that the activity of glutamic-pyruvic transaminase is obviously reduced, and hepatocyte necrosis is prevented;
the tuckahoe aqueous extract containing water-soluble micromolecular polysaccharide can increase the level of the isolated healthy human red blood cell 2, 3-DPG by about 25 percent and can effectively delay the exhaustion of the 2, 3-DPG in the incubation process.
Specifically, in the manufacturing process, step S1: screening and peeling almonds, then adding the almonds into a grinder for grinding to obtain almond powder, adding the almond powder into the grinder for grinding to obtain fine powder for later use, adding water into the almond powder to ensure that the mass content of almond meal reaches 10-15% (w/w), then heating, then carrying out colloid grinding to obtain almond meal slurry, heating the almond meal slurry to 45-55 ℃, adding alkaline protease and cellulase, when the hydrolysis degree reaches 10-15%, carrying out enzyme deactivation and centrifugation, and taking supernate as almond meal enzymatic hydrolysate; taking the mass of raw material almond meal as a calculation reference, wherein the adding amount of alkaline protease accounts for 0.6-1.2%, the adding amount of cellulase accounts for 1.0-1.5%, performing ultrafiltration membrane on almond meal enzymolysis liquid, collecting permeate, passing through strong acid gel type cation exchange resin, eluting by taking acid water as an eluent, and collecting eluent; concentrating the eluate in vacuum, spray drying to obtain bioactive peptide with uric acid lowering effect, mixing flos moutan, Poria, glycerol and deionized water in a mixing tank, heating to 75-80 deg.C under stirring at 20-30 rpm, and sterilizing at constant temperature for 20min to obtain water phase material;
step S6: adding the water phase material into an emulsifying machine, adding the oil phase material into the emulsifying machine for emulsification to obtain an emulsifying agent, and then adding the biological active peptide with the effect of reducing uric acid to obtain a product.
In a specific implementation process, in step S2, the heating temperature is 130 degrees celsius, and the heating time is 20 min.
In the specific implementation process, further, the oil phase raw materials in the step S6 are 1% -5% of mixed alcohol, 0.2% -0.8% of vaseline, 0.2% -0.8% of lanolin, and 8% -12% of liquid paraffin.
In a specific implementation process, in step S5, an ultrafiltration membrane of 10000Da is used for the membrane flux.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation. The use of the phrase "comprising one of the elements does not exclude the presence of other like elements in the process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. A meal bioactive peptide moisturizer with the effect of reducing uric acid is characterized by comprising the following components in parts by weight: 10-30 parts of almond meal, 10-30 parts of peony, 10-30 parts of white poria, 10-30 parts of glycerol and 10-30 parts of deionized water.
2. The preparation method of the cake bioactive peptide moisturizer with the effect of reducing uric acid according to claim 1, which is characterized in that,
step S1: screening and peeling almonds, then adding the almonds into a grinder for grinding to obtain almond powder, and adding the almond powder into a grinder for grinding to obtain fine powder for later use;
step S2, adding water into almond powder to make the mass content of almond meal reach 10-15% (w/w), then heating, and then passing through a colloid mill to obtain almond meal slurry;
step S3: heating the almond pulp slurry to 45-55 ℃, adding alkaline protease and cellulase, inactivating enzyme when the hydrolysis degree reaches 10-15%, centrifuging, and taking supernatant as almond pulp enzymatic hydrolysate; based on the mass of the raw material almond meal, the adding amount of the alkaline protease accounts for 0.6-1.2%, and the adding amount of the cellulase accounts for 1.0-1.5%;
step S4, filtering the almond meal enzymatic hydrolysate through an ultrafiltration membrane, collecting permeate, then filtering the permeate through strong acid gel type cation exchange resin, eluting the permeate with acidic water as an eluent, and collecting eluent; concentrating the eluent in vacuum, and spray drying to obtain bioactive peptide with uric acid reducing effect;
step S5: metering peony, chinaroot greenbrier rhizome, glycerol and deionized water into a mixing tank for mixing, continuously heating to 75-80 ℃ under the stirring of 20-30 r/m, and sterilizing at constant temperature for 20 minutes to obtain a water phase material;
step S6: adding the water phase material into an emulsifying machine, adding the oil phase material into the emulsifying machine for emulsification to obtain an emulsifying agent, and then adding the biological active peptide with the effect of reducing uric acid to obtain a product.
3. The preparation method of the cake bioactive peptide skin cream with the uric acid lowering effect according to claim 2, wherein in the step S2, the heating temperature is 130 ℃ and the heating time is 20 min.
4. The preparation method of the cake bioactive peptide skin cream with uric acid lowering effect as claimed in claim 2, wherein the oil phase raw materials in step S6 are mixed alcohol 1% -5%, vaseline 0.2% -0.8%, lanolin 0.2% -0.8%, and liquid paraffin 8% -12%.
5. The method for preparing cake bioactive peptide moisturizer with uric acid reducing effect according to claim 2, wherein the membrane flux in step S5 is 10000Da ultrafiltration membrane.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010860806.3A CN112168734A (en) | 2020-08-25 | 2020-08-25 | Meal bioactive peptide moisturizer with effect of reducing uric acid |
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| CN202010860806.3A CN112168734A (en) | 2020-08-25 | 2020-08-25 | Meal bioactive peptide moisturizer with effect of reducing uric acid |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103565730A (en) * | 2013-11-13 | 2014-02-12 | 郑州市嘉蓓丽生物科技有限公司 | Scented tea whitening skin-moistening cream and preparation method thereof |
| CN103627760A (en) * | 2013-10-16 | 2014-03-12 | 华南理工大学 | Method for preparing biological active peptide with effect of reducing trioxypurine by using walnut protein |
| CN106811502A (en) * | 2015-12-01 | 2017-06-09 | 江南大学 | The preparation method of the skincare product containing almond polypeptide |
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2020
- 2020-08-25 CN CN202010860806.3A patent/CN112168734A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103627760A (en) * | 2013-10-16 | 2014-03-12 | 华南理工大学 | Method for preparing biological active peptide with effect of reducing trioxypurine by using walnut protein |
| CN103565730A (en) * | 2013-11-13 | 2014-02-12 | 郑州市嘉蓓丽生物科技有限公司 | Scented tea whitening skin-moistening cream and preparation method thereof |
| CN106811502A (en) * | 2015-12-01 | 2017-06-09 | 江南大学 | The preparation method of the skincare product containing almond polypeptide |
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Application publication date: 20210105 |
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