CN104013560A - Traditional Chinese medicine composition with whitening effect and application thereof in cosmetics - Google Patents
Traditional Chinese medicine composition with whitening effect and application thereof in cosmetics Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with a whitening effect. The traditional Chinese medicine composition is characterized by consisting of the following raw materials: 30-50 percent of Chinese angelica, 25-35 percent of rhizoma bletillae, 10-15 percent of Lysimachia christinae Hance, 10-15 percent of sage and 5-10 percent of liquorice. The preparation method comprises the following steps: grinding the traditional Chinese medicine composition, screening, adding an extraction solvent according to a liquid material mass ratio of 10:1-30:1, soaking for 1-2 hours, performing normal temperature extraction under the pressure of 50-100MPa by using a high-pressure homogenizing extractor, performing centrifugal separation on the extracting solution, adsorbing by using a macroporous resin, repeatedly eluting by using 10-95 percent of ethanol, collecting the eluent, performing reduced pressure concentration until the mass ratio of the extracting solution to the traditional Chinese medicine is 1:0.5-1:10; and adding butanediol with the same mass as the extracting concentrate, filtering and preparing the extract of the traditional Chinese medicine composition. The extract of the traditional Chinese medicine composition prepared by the method has the effects of strongly inhibiting melanogenesis, eliminating free radicals and realizing sun protection, is used in cosmetics and achieves the effect of whitening the skin.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of whitening Chinese medicament compositions and the application of extract in cosmetics thereof.
Background technology
China, from ancient times with Bai Weimei, as the saying goes " a white screening hundred is ugly ", and whitening skin is to pursue lifetime of many Mies.Except born skin infrablack, from traditional Chinese medical science angle, healthy not good enough often in vain, internal organs disorder of QI and blood, the performance in sub-health state, often shows face and occurs the symptoms such as chloasma, freckle.Treatment for facial speckle has the methods such as laser or intensive pulsed light, external medication; Wherein laser or intensive pulsed light method are very large to skin lesion, are of little use; Cosmetics whitening is current the most frequently used method.
All there is larger defect in the management of China's skin-lightening cosmetic and technology, the phenomenon of adding is in violation of rules and regulations very serious, what have even usings the contrabands such as aminomercuric chloride as whitening agent or adds the peroxide such as hydrogen peroxide and bleach, many beauty treatment accidents have been caused for many years, even disfeature, to consumer, cause very large injury, caused the great attention of country and consumer.In recent years, the whitening agent using in cosmetics mainly contains the compounds such as hydroquinone (hydroquinone), L-AA (vitamin C), kojic acid, superoxide dismutase (SOD) and arbutin.But these whitening agents exist many defects, as the zest of hydroquinone is very large, vitamin C and SOD are very unstable, and kojic acid also has certain zest and property easy to change, the single and poor effect of arbutin effect etc.So exploitation has good safety, stability, inhibition is obvious, and the natural whiting agent that cost performance is good, has become one of main direction of studying of current medicine and cosmetic industry, has extraordinary development prospect.
Chinese medicine whitening is one of important content of Chinese medicine beauty treatment, is also an important component part of Chinese medical.In Chinese medicine whitening, be particular about the slow thin reason of adjusting, take and effect a permanent cure as main, curative effect is also relatively stable, this be one very traditional, but lasting, safe and effective method.
Summary of the invention
Object of the present invention is just to provide the preparation technology of the extract of a kind of natural safe whitening Chinese medicament compositions and this Chinese medicine composition.
To achieve the object of the present invention, the present invention has adopted following technical scheme:
A whitening Chinese medicament compositions, is characterized in that the component that comprises following percentage by weight: Radix Angelicae Sinensis 20 ~ 50%, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 30%, Herba Lysimachiae 6 ~ 18%, Salvia japonica Thunb. 5 ~ 20%, Radix Glycyrrhizae 5 ~ 15%.
Preferably, described whitening Chinese medicament compositions (
i) percentage by weight is: Radix Angelicae Sinensis 38%, Pseudobulbus Bletillae (Rhizoma Bletillae) 24%, Herba Lysimachiae 14%, Salvia japonica Thunb. 10%, Radix Glycyrrhizae 14%.
Preferably, described whitening Chinese medicament compositions (
iI) percentage by weight is: Radix Angelicae Sinensis 40%, Pseudobulbus Bletillae (Rhizoma Bletillae) 28%, Herba Lysimachiae 12%, Salvia japonica Thunb. 10%, Radix Glycyrrhizae 10%.
Preferably, described whitening Chinese medicament compositions (
iII) percentage by weight is: Radix Angelicae Sinensis 35%, Pseudobulbus Bletillae (Rhizoma Bletillae) 25%, Herba Lysimachiae 15%, Salvia japonica Thunb. 13%, Radix Glycyrrhizae 12%.
The preparation technology of the extract of above-mentioned whitening Chinese medicament compositions, it is characterized in that: by proportioning, take raw material of Chinese medicine Radix Angelicae Sinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lysimachiae, Salvia japonica Thunb., Radix Glycyrrhizae, above-mentioned Chinese medicine composition is pulverized, sieve, by liquid material mass ratio, be that 10:1 ~ 30:1 adds extraction solvent, soak after 1 ~ 2h, under 50 ~ 100MPa pressure, with high pressure homogenize extractor, carry out extract at room temperature, extracting solution is after centrifugalize, by macroporous resin adsorption, ethanol with 10 ~ 95% is eluting repeatedly, collect eluent, the mass ratio that is evaporated to extracting solution and Chinese medicine is 1:0.5 ~ 1:10, add again with the butanediol that extracts concentrated solution equal in quality and dissolve, filter, make the extract of Chinese medicine composition.For fear of dissolvent residual, the extraction solvent using in the present invention can adopt water, ethanol, ethanol water.
The second object of the present invention be by the extract of above-mentioned whitening Chinese medicament compositions for cosmetics, make stable in properties, respond well skin-lightening cosmetic.
For realizing the second object of the present invention, the present invention has adopted following technical scheme: the extract of above-mentioned Chinese medicine composition is used for to preparing cosmetics, it is characterized in that the extract that contains above-mentioned Chinese medicine composition in cosmetics, its consumption is 0.01 ~ 20%, and preferable amount is 1 ~ 10%.
The invention has the beneficial effects as follows: the present invention be take theory of Chinese medical science as basis, according to the theory of monarch, carries out compound recipe.In the present invention, when being classified as monarch drug, its nature and flavor are sweet, warm, return liver, the heart, spleen channel, and strongly invigorating primordial QI contains potent whitening and the compositions of invigorating blood circulation such as a large amount of volatile oil, flavone and ferulic acid, has the beauty functions of extraordinary preserve youthful looks foster skin, whitening and speckle dispelling.Pseudobulbus Bletillae (Rhizoma Bletillae) is that minister is wanted, its property is bitter, sweet, puckery, be slightly cold, return lung, liver, stomach warp, contain whitening, the moisturizing compounds such as abundant aminoacid, polysaccharide and cinnamic acid, the merit that has blood circulation promoting and blood stasis dispelling, astringing to arrest bleeding, detumescence and promoting granulation, says in < < Compendium of Materia Medica > > that it " washes one's face black, speckle dispelling ".The collaborative Salvia japonica Thunb. of Herba Lysimachiae is adjuvant drug, Herba Lysimachiae
sweet in the mouth,
micro-hardship, cool in nature, return
liver,
gallbladder,
kidney,
bladderwarp, contains the flavone compound that abundant Quercetin etc. has potent free radical resisting and whitening function, has the merit of clearing away heat and promoting diuresis, wind-expelling pain-stopping, hemostasia and promoting granulation, eliminating inflammation and expelling toxin; Salvia japonica Thunb. bitter in the mouth, pungent, property are flat, blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, removing toxic substances removing food stagnancy; Radix Glycyrrhizae is for making, coordinating the actions of various ingredients in a prescription, and sweet in the mouth, flat, enter spleen, stomach, lung meridian, contain potent whitening and the free radical resisting compositions such as abundant enoxolone, licoflavone, there is the merit of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, whitening and speckle dispelling.All medicines share above, can Synergistic, qi-supplementing, blood-engendering, the flourish skin of supporting, the strong bright colour of skin of body constitution, the merit of playing altogether conditioning viscera, Yin Yang balancing, control the bright skin of whitening this.The potent removing free radical of extract energy of Chinese medicine composition of the present invention, restraint of tyrosinase activity, uvioresistant, reduce melanin and generate, and accelerates skin surface cell renewal, and delaying skin aging, makes an addition in cosmetics, and the bright skin effect of whitening is remarkable.
Accompanying drawing explanation
Accompanying drawing 1 is the comparison diagram that uses the dermal melanin content of whitening and skin-protecting breast and common skin care milk.
The specific embodiment
By specific embodiment, come below that the present invention is further illustrated, but these embodiment are just in order to illustrate, are not limitations of the present invention.
extract (I) and the preparation method of embodiment 1 Chinese medicine composition
By proportioning, take raw material of Chinese medicine Radix Angelicae Sinensis 38g, Pseudobulbus Bletillae (Rhizoma Bletillae) 24g, Herba Lysimachiae 14g, Salvia japonica Thunb. 10g, Radix Glycyrrhizae 14g, above-mentioned Chinese medicine composition is pulverized, sieve, by liquid material mass ratio, be that to add volume fraction be 50% ethanol extraction solvent to 15:1, soak after 2h, under 80MPa pressure, with high pressure homogenize extractor, carry out extract at room temperature, extracting solution is after centrifugalize, by AB-8 type macroporous resin adsorption, by volume fraction, be respectively 30%, 60%, 90% ethanol is eluting repeatedly, collect eluent, be evaporated to extracting solution 50g, add again 50g butanediol to dissolve, filter, make the extract of 100g Chinese medicine composition.
extract (II) and the preparation method of embodiment 2 Chinese medicine compositions
By proportioning, take raw material of Chinese medicine Radix Angelicae Sinensis 40g, Pseudobulbus Bletillae (Rhizoma Bletillae) 28g, Herba Lysimachiae 12g, Salvia japonica Thunb. 10g, Radix Glycyrrhizae 10g, above-mentioned Chinese medicine composition is pulverized, sieve, by liquid material mass ratio, be that to add volume fraction be 60% ethanol extraction solvent to 18:1, soak after 1.5h, under 75MPa pressure, with high pressure homogenize extractor, carry out extract at room temperature, extracting solution is after centrifugalize, by D101 type macroporous resin adsorption, by volume fraction, be respectively 20%, 50%, 95% ethanol is eluting repeatedly, collect eluent, be evaporated to extracting solution 50g, add again 50g butanediol to dissolve, filter, make the extract of 100g Chinese medicine composition.
the preparation of comparative example 1-5 single medicinal material extract
Take respectively raw material of Chinese medicine Radix Angelicae Sinensis 100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Herba Lysimachiae 100g, Salvia japonica Thunb. 100g, Radix Glycyrrhizae 100g, above-mentioned Chinese medicine is pulverized respectively, sieve, by liquid material mass ratio, be that to add volume fraction be 50% ethanol extraction solvent to 15:1, soak after 2h, under 80MPa pressure, with high pressure homogenize extractor, carry out extract at room temperature, extracting solution is after centrifugalize, by AB-8 type macroporous resin adsorption, by volume fraction, be respectively 30%, 60%, 90% ethanol is eluting repeatedly, collect eluent, be evaporated to extracting solution 50g, add again 50g butanediol to dissolve, filter, make 100g Radix Angelicae Sinensis extracting solution, Pseudobulbus Bletillae (Rhizoma Bletillae) extracting solution, Herba Lysimachiae extracting solution, Salvia japonica Thunb. extracting solution, Radix Glycyrrhizae extract.
the preparation of embodiment 3 whitening and skin-protecting breasts
Table 1 provides the whitening and skin-protecting breast formula that contains Chinese medicine extraction compositions, and the consumption of each material represents with mass fraction.
Table 1
The preparation method of whitening and skin-protecting breast: the Cyclomethicone in formula table, ring five polydimethylsiloxane, isopropyl palmitate, Miglyol 812, monoglyceride, stearic acid, methyl hydroxybenzoate, propylparaben are mixed, be heated to 80 ℃, fusing stirs, as oil phase; 1,2-PD in formula table, allantoin, Chinese medicine extraction compositions, triethanolamine, deionized water are mixed, be heated to 85 ℃, stirring and dissolving is even, as water.Oil phase and water are added in emulsifying pot, stir, emulsifying homogeneous, after 6 minutes, stirs while being cooled to 50 ℃, adds essence, stirs, and is cooled to 38 ℃, is whitening and skin-protecting breast.
the preparation of comparative example 6 common skin care milks
Table 2 provides the common skin care milk formula that does not contain Chinese medicine extraction compositions, and the consumption of each material represents with mass fraction.
Table 2
The preparation method of common skin care milk: the Cyclomethicone in formula table, ring five polydimethylsiloxane, isopropyl palmitate, Miglyol 812, monoglyceride, stearic acid, methyl hydroxybenzoate, propylparaben are mixed, be heated to 80 ℃, fusing stirs, as oil phase; 1,2-PD in formula table, allantoin, triethanolamine, deionized water are mixed, be heated to 85 ℃, stirring and dissolving is even, as water.Oil phase and water are added in emulsifying pot, stir, emulsifying homogeneous, after 6 minutes, stirs while being cooled to 50 ℃, adds essence, stirs, and is cooled to 38 ℃, is common skin care milk.
embodiment 4 whitening sleep surface film preparations
Table 3 provides the whitening sleep surface film formulation of the extract that contains Chinese medicine composition of the present invention.
Table 3
Its preparation method:
1, by oil phase raw material in advance stirring and dissolving to being uniformly dispersed, by interpolation phase raw material methyl hydroxybenzoate and propyl hydroxybenzoate in advance in 1.3-butanediol heating for dissolving to clear, standby.
2, water raw material is fed in deionized water, is heated to 75 ~ 85 ℃, be stirred to and be uniformly dissolved.
3, oil phase (1000 ~ 2000rpm) under stirring condition is slowly at the uniform velocity joined in water, after adding, under homogenizing speed 4000 ~ 6000rpm, reemulsification is 5 ~ 10 minutes.
4, be cooled to 40 ℃, add active Chinese drug component extractive part and essence, then drip aminomethyl propanol adjusting pH value to 5.5 ~ 6.5.
5, stir, be cooled to 35 ℃, the deaeration of repetition measurement pH final vacuum, filters discharging.
experimental example 1 extract whitening function in-vitro evaluation experiment
1, the preparation of sample
The extract of Chinese medicine composition prepared by the embodiment 1 of take and single medicinal material extract prepared by comparative example 1-5 are sample.Sample 1g is dissolved in 99g dimethyl sulfoxine, is made into mass fraction and is 1% sample solution, carry out test below.
2, restraint of tyrosinase vigor effect assessment test
The DOPA solution that is 0.1 % by table 4 phosphate buffered solution (PBS) that accurately absorption sample solution, pH value are 6.8 and mass fraction, fully mix, in 30 ℃, hatch after 5 min, adding activity is the tryrosinase solution of 110 U/mL, at 30 ℃, hatch again 10 min, be transferred to rapidly in cuvette, at 475 nm places, survey absorbance.
Table 4
| Reactant liquor composition | 1 group | 2 groups | 3 groups | 4 groups |
| Sample solution/mL | 1 | 1 | ||
| Phosphate buffered solution/mL | 2 | 2.5 | 1 | 1.5 |
| DOPA solution/mL | 1 | 1 | 1 | 1 |
| Tryrosinase solution/mL | 0.5 | 0.5 | ||
| Cumulative volume/mL | 3.5 | 3.5 | 3.5 | 3.5 |
By formula (1) calculation sample to the relative inhibition of tryrosinase (
i, be called for short suppression ratio, lower same).
I=[(A1-A2)-(A3-A4)]×100%÷(A1-A2) （1）
In formula: A1, A2, A3, A4 are respectively the absorbance of 1 group～4 groups of solution.
3, melanin synthetic test in check melanin cell
By B16 melanoma cell with 1 * 10
5the density of individual/mL is inoculated in 96 orifice plates, and every hole 90 μ L, hatched in CO2 incubator after 24 hours, and every hole adds sample solution.Set up the blank group of culture medium and cell simultaneously.
Culture plate is placed in to incubator and hatches after 72 hours, abandoning supernatant, PBS washing twice, then every hole adds 0.5mL trypsin digestion cell 3min, and every hole adds 2mL maintenance medium to stop digestion.After mixing, every kind of concentration is taken out 0.5mL and is made cell counting.All the other cell suspension are with 2500r/min centrifugalize 5min, and abandoning supernatant adds NaOH solution in precipitation, and heating is dissolved melanin, select 490nm wavelength to measure absorbance under enzyme-linked immunosorbent assay instrument.By formula (2) calculation sample to the synthetic suppression ratio of melanin (
i').
I’=(1-A5÷P1/A6÷P2)×100% （2）
In formula: A5 is medicine hole absorbance; P1 is medicine porocyte density; A6 is control wells absorbance; P2 is control wells cell density.
4, ultra-oxygen anion free radical is removed effect assessment test
Press table 5 and add medicinal liquid.Extracting sample solution 2 mL, add 2.25 mL Tris-HCl buffer solution (pH 8.36), and after 0.25 mL concentration is 10 mmoL/L pyrogallol solution, water-bath at 25 ℃, drips 1 of 10 mol/L hydrochloric acid, cessation reaction during 4min.With ultraviolet spectrophotometer, under 420 nm, survey absorbance.According to formula (3), calculate clearance rate (D).
D=[1-(A9-A10)÷(A7-A8)]×100% （3）
In formula: A7 is that pyrogallol issues and is conigenous the absorbance of sending out oxidation reaction generation O2-at Tris-HCl solution; A8 is the absorbance of Tris-HCl solution; A9 is for removing the absorbance of O2-reaction; A10 is the absorbance of medicine.
Table 5
| Reaction group | Tris-HCl | Pyrogallol | Sample solution | Deionized water |
| F 0 | 2.25 mL | 0.25 mL | 0 mL | 2 mL |
| F 1 | 2.25 mL | 0.25 mL | 2 mL | 0 mL |
| F 2 | 2.25 mL | 0 mL | 2 mL | 0 mL |
5, uvioresistant effect assessment test
According to the light industry standard QB/T 2334-1997(of People's Republic of China (PRC) cosmetics middle-ultraviolet lamp absorbent qualitative determination-ultraviolet spectrophotometry) test.Sample solution is diluted to 10 times again with ethanol, then, within the scope of 280 ~ 400nm, every 10nm, scan, determine the absorbance under each wavelength, and calculate mean light absorbency.
6, experimental result
The experiment of whitening and skin-protecting effect assessment is shown in Table 6.
Table 6
Experimental result shows, Chinese medicine extraction compositions of the present invention can have significantly that restraint of tyrosinase is active and check melanin is synthetic, removing free radical and anti-ultraviolet function, and improve significantly than the effect of single medicinal material extract, illustrate between different Chinese medicine and brought into play synergistic function.
experimental example 2 whitening and skin-protecting breast human body evaluation experimental on probation
1, experimental technique
The whitening and skin-protecting breast of embodiment 3 preparations and the common skin care milk of comparative example 6 preparations carry out respectively human body evaluation on probation.Choose the age 40 of the healthy volunteers (20 of male, 20 of women) of 20 ~ 50 years old.Using method is to use after clean of every day, uses every day twice (after getting up morning and each before sleep in evening once), and left face is used the whitening and skin-protecting breast of press embodiment 3 preparations, and right face is used the common skin care milk of preparing by comparative example 6.Experimental period is one month, the dermal melanin of results of regular determination volunteer face, and in use sample is carried out to moisturizing degree, glossiness and the sensory evaluation of whitening degree, and wherein best result is 5, is minimumly divided into 1.
2, experimental result
Accompanying drawing 1 is the comparison diagram that uses the dermal melanin content of whitening and skin-protecting breast and common skin care milk.Accompanying drawing 1 result shows, uses dermal melanin content after the whitening and skin-protecting breast of embodiment 3 preparations obviously low than dermal melanin content after using the common skin care milk of comparative example 6 preparations.
According to sensory evaluation, fill in evaluation table on probation.Collect half face experiment evaluation table on probation, statistical result is in Table 7.
Table 7 human body is tried out evaluation result meansigma methods
| Evaluation result | Comparative example 6 | Embodiment 3 |
| Moisturizing degree | 3 minutes | 4 minutes |
| Glossiness | 2 minutes | 5 minutes |
| Whitening degree | 1 minute | 5 minutes |
From table 7 result, use skin glossiness and whitening degree after the whitening and skin-protecting breast of embodiment 3 preparations obviously than common skin care milk good of using comparative example 6 preparations
Above result shows the whitening and skin-protecting breast containing the extract of Chinese medicine composition of the present invention, has the effect that good whitening is nourished, and can allow coarse dark and gloomy skin speedy recovery to health state, and smooth exquisiteness is pale moving.
Claims (2)
1. a whitening Chinese medicament compositions, is characterized in that the component that comprises following percentage by weight: Radix Angelicae Sinensis 20 ~ 50%, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 30%, Herba Lysimachiae 6 ~ 18%, Salvia japonica Thunb. 5 ~ 20%, Radix Glycyrrhizae 5 ~ 15%, the preparation method of the extract of Chinese medicine composition is: by proportioning, take raw material of Chinese medicine Radix Angelicae Sinensis, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lysimachiae, Salvia japonica Thunb., Radix Glycyrrhizae, above-mentioned Chinese medicine composition is pulverized, sieve, by liquid material mass ratio, be that 10:1 ~ 30:1 adds extraction solvent, soak after 1 ~ 2h, under 50 ~ 100MPa pressure, with high pressure homogenize extractor, carry out extract at room temperature, extracting solution is after centrifugalize, by macroporous resin adsorption, ethanol with 10 ~ 95% is eluting repeatedly, collect eluent, the mass ratio that is evaporated to extracting solution and Chinese medicine is 1:0.5 ~ 1:10, add again with the butanediol that extracts concentrated solution equal in quality and dissolve, filter, make the extract of Chinese medicine composition, for fear of dissolvent residual, the extraction solvent using in the present invention can adopt water, ethanol, ethanol water.
2. the application of the extract of Chinese medicine composition claimed in claim 1 in preparing cosmetics, is characterized in that the extract that contains above-mentioned Chinese medicine composition in cosmetics, and its consumption is 0.01 ~ 20%, and preferable amount is 1 ~ 10%.
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| CN104523536A (en) * | 2015-01-24 | 2015-04-22 | 黄荣波 | Whitening and moisturizing cosmetic containing Asiatic pennywort herb extract and preparation method of whitening and moisturizing cosmetic |
| CN105832623A (en) * | 2016-06-12 | 2016-08-10 | 马殿伟 | Verbena officinalis-containing traditional Chinese medicine composition for whitening cosmetics |
| CN106333919A (en) * | 2016-10-28 | 2017-01-18 | 秦科 | Traditional Chinese medicine skin whitening mask and preparation method thereof |
| CN106389285A (en) * | 2016-10-28 | 2017-02-15 | 秦科 | Traditional Chinese medicine mask and preparation method thereof |
| CN106540085A (en) * | 2016-11-26 | 2017-03-29 | 广东轻工职业技术学院 | A kind of Chinese medicine composition of whitening anti-aging and the application in cosmetics |
| CN106580764A (en) * | 2016-10-23 | 2017-04-26 | 广东轻工职业技术学院 | Plant composition with efficacy of whitening skin and applications of plant composition in cosmetics |
| CN106619355A (en) * | 2016-10-23 | 2017-05-10 | 广东轻工职业技术学院 | Moisturizing traditional Chinese medicinal composition and application thereof |
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| CN105832623A (en) * | 2016-06-12 | 2016-08-10 | 马殿伟 | Verbena officinalis-containing traditional Chinese medicine composition for whitening cosmetics |
| CN106580764A (en) * | 2016-10-23 | 2017-04-26 | 广东轻工职业技术学院 | Plant composition with efficacy of whitening skin and applications of plant composition in cosmetics |
| CN106619355A (en) * | 2016-10-23 | 2017-05-10 | 广东轻工职业技术学院 | Moisturizing traditional Chinese medicinal composition and application thereof |
| CN106333919A (en) * | 2016-10-28 | 2017-01-18 | 秦科 | Traditional Chinese medicine skin whitening mask and preparation method thereof |
| CN106389285A (en) * | 2016-10-28 | 2017-02-15 | 秦科 | Traditional Chinese medicine mask and preparation method thereof |
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| CN110833520A (en) * | 2019-12-14 | 2020-02-25 | 广州伊尔美生物科技有限公司 | Anti-aging composition |
| CN110833520B (en) * | 2019-12-14 | 2022-02-01 | 广州伊尔美生物科技有限公司 | Anti-aging composition |
| CN115590799A (en) * | 2022-11-07 | 2023-01-13 | 苏勇铭（Cn） | Anti-wrinkle whitening composition, essence and preparation method thereof |
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