CN106473987B - The anti-ageing composition of whitening and cosmetics - Google Patents
The anti-ageing composition of whitening and cosmetics Download PDFInfo
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- CN106473987B CN106473987B CN201611073785.0A CN201611073785A CN106473987B CN 106473987 B CN106473987 B CN 106473987B CN 201611073785 A CN201611073785 A CN 201611073785A CN 106473987 B CN106473987 B CN 106473987B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The present invention relates to cosmetic technical fields, the in particular to anti-ageing composition of whitening and cosmetics.The anti-ageing composition of the whitening is made of saskatoon extract, green-tea extract, Gotu Kola P.E and Huai Goat.The effect of anti-ageing composition of whitening of the invention and cosmetics the selected natural extract component from Four Plants of ingredient, it can effectively be inhibited tyrosinase activity after being applied in combination, inhibit the generation of melanin, the significant removing machine interior free yl of energy, it is anti-ageing to whitening to have the function of complementary synergy with stronger antioxidation.
Description
Technical field
The present invention relates to cosmetic technical fields, the in particular to anti-ageing composition of whitening and cosmetics.
Background technique
Nowadays problem of environmental pollution is serious, and the operating pressure of people is big, lives irregular, causes skin to occur intensely dark
The various problems such as relaxation, microgroove color spot, drying.Everybody has a love of beauty, and people save oneself by various cosmetics
Skin.Most of cosmetics contain the substances such as lead, mercury, benzene, preservative, hormone currently on the market, although can temporarily make the skin be in
Existing glossy soft state, but it is used for a long time that cuticula can be made to fall off is thinning, lead to red swelling of the skin, form color spot, effect is suitable to obtain it
Instead, therefore the safety of cosmetics becomes consumer and buys the primary factor considered when cosmetics.With flying for cosmetic industry
Speed development, the cry of " component is naturally changed " and " going back to nature " have become the trend of cosmetics industry, the raw material day of cosmetics
Rightization is by attention.Pure natural whitening composition is increasingly becoming a chief component in cosmetics.
The content of melanin is the important factor in order of the skin color depth, and the content of melanin is more, the colour of skin of skin
It is more black.Melanin is by tyrosine under the catalysis of tyrosinase, through generating a series of metabolic response shapes such as DOPA, DOPA quinone
At, therefore, inhibiting tyrosinase activity is the key that in place of reducing melanin production.In addition, leading to the most common of aging
Endogenous Some Circulating Factors are free radicals, so particularly important for anti-aging, removing free radical.In recent years, tyrosinase inhibits
Agent, the research of antioxidant are very active, and there are commonly salicylic acid, azelaic acid class, arbutin, tartaric acid, ascorbic acid, kojic acid
Or the derivative etc. synthesized by them, the place but these all come with some shortcomings, such as the cytotoxicity of quinhydrones and kojic acid, skin
Skin irritation is larger；Ascorbic acid is unstable, is easily oxidized, and percutaneous absorbtion is poor；Tartaric acid has certain irritation to skin, long
It is more sensitive to ultraviolet light that phase use will lead to skin.Therefore, natural junket ammonia that is stable, effective and having no adverse reaction to human body is found
Sour enzyme inhibitor, powerful antioxidant have become the trend of cosmetic industry research, using natural plant extracts as functional component
Pure natural cosmetic becomes the trend of cosmetic product exploitation because of traction with higher and environmental friendliness.
Publication No. is a kind of fragrant plant combination with whitening antioxidation of the patented invention of CN104784069A
Object, fragrant plant composition used are prepared by lemon grass (Cymbopogon citratus), peppermint, lotus, tree peony, rose, have good white-skinned face function
With hydroxyl radical free radical Scavenging activity, and assign cosmetics natural aromatic taste.
Publication No. provides a kind of skin lightening compositions containing natural botanical source for the patent of CN105434239A and exists
Application in cosmetics, the whitening active group is divided into gadol extract and mulberry-leaf extract, safe to the human body, to tyrosine
Enzymatic activity has inhibiting effect.
Currently, consumer for natural component the cosmetics for having effects that whitening is anti-ageing there is still a need to.
Summary of the invention
In view of this, the present invention provides a kind of anti-ageing composition of whitening and cosmetics.The anti-ageing composition of the whitening can
It effectively inhibits tyrosinase activity, there is stronger antioxidation, there is remarkable efficacy at the anti-ageing aspect of whitening.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of anti-ageing compositions of whitening, are extracted by saskatoon extract, green-tea extract, centella
Object and Huai Goat composition.
Saskatoon is a kind of defoliation small arbor of rosaceae Amelanchier or shrub, originates in Canada and the U.S., fruit
For the operatic circle shape berry, rich in nutrition content, calcium content is occupied first of all kinds of fruits, and every 88 milligrams of 100g fresh fruit calcic, and containing a large amount of
The minerals such as the daily required total dietary fiber of human body, each biostearin and necessary potassium, iron, magnesium, manganese, are in addition also rich in 18
Kind amino acid.Either still at being grouped as, there are certain similarities with blueberry for appearance, taste.According to one, North America biology
The research of extraction company reports, the contents level of the antioxidant tea polyphenols and nutrient for plants that contain in saskatoon and blue
The certain kind of berries, cowberry are suitable, and the total phenol content in every 100g is 452mg, the Polyphenols contained, procyanidine, anthocyanidin, chlorogenic acid etc.
Antioxidant is in terms of the disease incidence and auxiliary for reducing a variety of diseases such as cancer, heart disease, diabetes carry out clinical treatment
Preferable effect, and pectin also rich in are shown, pectin is the main component of dietary fiber, has good anti-abdomen
It rushes down, anticancer, treatment diabetes and weight-reducing and other effects.The product of saskatoon is up to tens kinds at present, including makes wine, eats fruit raw
Product, health care medicine, advanced drink etc., but it is not directed to cosmetic field.
Green tea tea polyphenols rich in, tea polyphenols are the compounds of a kind of polyhydroxy phenols being present in tea tree,
Main component is catechin flavanol compound, flavones and flavonols, anthocyan and phenolic acid and the more compounds of depside
Compound.Tea polyphenols category polyphenol structure, can chelate 10 metal ion species such as calcium, copper, iron, by acting on chelating copper ions,
And the oxidation for the low-density lipoprotein for inhibiting copper to be catalyzed, so that the SOD for guaranteeing to will not influence in a certain range centered on copper is living
Property, and then inhibit tyrosinase activity the generation for reducing melanin.In addition, people can generate nocuousness freely in metabolic process of life
Base, the extremely strong oxidability of free radical can aoxidize unsaturated fatty acid and form lipid peroxide, and the meeting of accumulation slackens biomembrane
Normal function influences the metabolism of active material, and tea polyphenols have multiple ortho position phenolic hydroxyl structures, because polyphenol hydroxyl is easily by oxygen
It turns to quinones and proton H is provided, therefore have stronger inoxidizability.Meanwhile tea polyphenols itself generate stable free radical intermediate,
Inhibit original free radical chain reactions, to protect cell component injury-free, compared with other antioxidants, tea polyphenols are clear
Except oxygen radical has high efficiency, compared with free radical scavenger, the efficiency of tea polyphenols scavenging activated oxygen is equivalent to 9 micrograms
Cu, Zn-SOD.Compared with VC, VE its scavenging activated oxygen, hydroxyl radical free radical efficiency want several times high.Furthermore tea polyphenols and VC,
VE has fabulous synergistic effect.It can produce with VC, VE in protective, improve the content of internal VC, VE, and tea polyphenols can
Free radical can be removed with water-soluble and fat-soluble two ways simultaneously, it is more more effective than single reducing agent.Tea polyphenols also have anti-
Radiation effects and anti-allergic effects can absorb radioactive substance, referred to as natural ultraviolet filter.It can also be by inhibiting scorching
The inflammatory cytokine of excessive secretion plays anti-inflammatory effect during disease.The actually rare skin with huge potentiality
Whitening agent.Publication No. is to be mentioned in the patent of CN101491490A when green-tea extract concentration is 1mg/mL, to tyrosine
The inhibiting rate of enzyme is 85%, and the IC50 value of its tyrosinase inhibition rate is 0.101mg/mL, this shows green-tea extract to junket
The activity of propylhomoserin enzyme has significant inhibiting effect.
Centella is the drying herb or whole herb with root of umbelliferae centella, and all herbal medicine can be adopted throughout the year.In many
It is applied in the field of medicaments of country and has thousands of years history.It is classified as middle product first recorded in Shennong's Herbal.Its is cold in nature, bitter,
It is pungent, there is clearing heat and promoting diuresis, the efficacy of removing toxicity for detumescence to imitate, be mainly used for jaundice with damp-heat pathogen, heatstroke diarrhea, sand drenches blood strangury, and the swollen sore of pain falls
Flutter damage.Gotu Kola P.E triterpenes containing there are many, wherein including α-amyrin structure, main component is Asiaticoside,
Asiatic acid and brahmic acid.Enzyme type and non-enzyme type polyphenoils discrimination in newly-generated tissue can be improved in Gotu Kola P.E
Change the content of enzyme, hydrogen peroxide, glutathione peroxidase, vitamin E and ascorbic acid usp/bp, has anti-oxidant, anti-ageing
Strong skin of waiting for a long time acts on.Gotu Kola P.E is smoothed by OTC skin nursing recommendation for the regenerated scar of ageing skin (can be in shaping
It is used after operation).Centella can make skin limber up with compact epidermis and corium coupling part, help to solve skin pine
Relaxation phenomenon forms collagen in the flexible promotion skin corium of skin smooth, regenerates fibrin, and reconnect is got up,
Achieve the effect that skin compact smooth.Impaired organization healing and consolidation skin can also be helped.It can promote epidermis and corium
Between close connection, and the increase of fat cell can be inhibited, prevent hydroderma, occur it is fat.Recent study discovery product
Snow grass has the effects that anti-oxidant, antidepression, liver protection, inhibits tumor cell proliferation.
The sophora bud is the bud of leguminous plant Chinese scholartree (Sophora japonica L.), has more than 2000 years medicinal histories, " mind
Agriculture book on Chinese herbal medicine warp " also it is classified as top grade.Contain the ingredients such as rutin, Quercetin, triterpenoid saponin, polysaccharide lymphatic temperament, rutin in the sophora bud
It is natural flavone compound for main component, one of main component of citrin, content is up to 12-20%.In recent years
Domestic and international medical personal studies sophora bud effect, it is found that its effective component has anti-cancer and cancer-preventing, platelet aggregation-against, town
Bitterly, antibacterial, antiviral, anti-aging, anti-inflammatory, antiallergy, free radical resisting and the various actives such as anti-oxidant, to improve myocardial circulation,
Clearing heat and detoxicating, reducing blood lipid, softening blood vessel, anti-inflammatory kidney tonifying etc. have good preventive and therapeutic effect, nontoxic to the human body, harmless, no lethal, cause
Cancer, teratogenesis, mutagenesis.Rutin can enhance the toughness of capillary, reduce capillary permeability and brittleness, keep and restore
The normal elasticity of capillary has effects that prevent rupture of blood vessel in brain to hypertensive patient have stronger pharmacological action.And
Rutin has very strong absorption to ultraviolet light, and when additive amount is 10%, the absorptivity of ultraviolet light is up to 98%, has apparent
The effect of scavenger-cell active oxygen radical is a kind of broad spectrum sunscreen ideal at present.
The present invention will have effects that significant whitening is anti-ageing after above-mentioned Four Plants extract combination use, and effect is better than respectively
Plant extracts is used alone, and embodies apparent synergistic function.The composition is applied in cosmetics, change has been complied with
The trend of adornment industry meets consumer's demand natural to cosmetics, green, safe and efficient.
Preferably, in parts by weight, the anti-ageing composition of whitening includes: 1~6 part of saskatoon extract, green tea is extracted
0.5~5 part of object, 1~4 part of Gotu Kola P.E, 0.8~3 part of Huai Goat.
In an embodiment provided by the invention, in parts by weight, the anti-ageing composition of whitening includes: saskatoon extract
1 part, 3 parts of green-tea extract, 4 parts of Gotu Kola P.E, 0.8 part of Huai Goat.
In another embodiment provided by the invention, in parts by weight, the anti-ageing composition of whitening includes: that saskatoon extracts
3 parts of object, 5 parts of green-tea extract, 1 part of Gotu Kola P.E, 2 parts of Huai Goat.
In another embodiment provided by the invention, in parts by weight, the anti-ageing composition of whitening includes: that saskatoon extracts
6 parts of object, 0.5 part of green-tea extract, 3 parts of Gotu Kola P.E, 3 parts of Huai Goat.
Preferably, saskatoon extract is saskatoon alcohol extract.
Preferably, saskatoon alcohol extract the preparation method comprises the following steps: 180 will be crushed to after saskatoon clean dry~
200 mesh, addition are equivalent to 8~20 times of raw material weight of concentration of volume percent for 40%~90% ethyl alcohol, at 55~85 DEG C
It extracts 2~4 times, 1~3h, combined extract, filtering, filtrate decompression concentration, drying obtain saskatoon alcohol extract every time.
In embodiment provided by the invention, saskatoon alcohol extract the preparation method comprises the following steps: by saskatoon clean dry
After be crushed to 180 mesh, the ethyl alcohol for being equivalent to that 15 times of raw material weight of concentration of volume percent is 75% is added, extracts 3 at 70 DEG C
Secondary, each 2h, combined extract, filtering, filtrate decompression concentration is dry, obtains saskatoon alcohol extract.
The present invention also provides a kind of cosmetics, including saskatoon extract, green-tea extract, Gotu Kola P.E,
Acceptable auxiliary material on Huai Goat and cosmeceutical.
Preferably, acceptable auxiliary material includes that propylene glycol, emollient, moisturizer, thickener, spermaceti are hard on cosmeceutical
Lipidol, cetearyl glucoside, Glyceryl stearate citrate, pungent glycol, Sensiva SC50, rose, EDTA-
2Na, pH adjusting agent and water.
Preferably, in terms of mass percentage, dosage of each component in cosmetics are as follows:
Preferably, emollient is wheat-germ oil, macadimia nut oil, jojoba oil, avocado oil, shea butter, sweet tea apricot
One or more of benevolence oil, Semen Coicis oil, rice bran oil, safflower oil or myristyl alcohol myristinate.
Preferably, emollient is wheat-germ oil, macadimia nut oil, jojoba oil, avocado oil, shea butter, dessert almond
Two or more in oil, Semen Coicis oil, rice bran oil, safflower oil or myristyl alcohol myristinate.
Preferably, moisturizer is ethoxy urea, ceramide, Sodium Hyaluronate, levulan, allantoin, reed fragrant plant oil, mountain
One or more of pears sugar alcohol or glycine betaine.
Preferably, thickener is carbomer, xanthan gum, seaweed glue, guar gum, chitosan, Arabic gum or Caesalpinia spinosaKuntze
One or more of glue.
Preferably, pH adjusting agent is the one or two of citric acid or triethanolamine.
Preferably, the pH value of cosmetics of the present invention is 5~7.
The present invention also provides the preparation methods of the cosmetics, include the following steps:
Emollient, cetostearyl alcohol, cetearyl glucoside, Glyceryl stearate citrate are mixed, are heated to
80~85 DEG C, stirring keeps the temperature 5~10min, obtains oily phase to being completely dissolved；
Water, propylene glycol, thickener, pungent glycol, ethyl hexyl glycerol, EDTA-2Na are mixed, are heated with stirring to 80~85 DEG C,
It dissolves it sufficiently, obtains water phase；
By mutually mixed with water, the 2~5min of homogeneous of oil, 30~35min is then kept the temperature；
When temperature is down to 40~45 DEG C, moisturizer, saskatoon extract, green-tea extract, centella is added and extracts
Object and Huai Goat, stir evenly, and cool down after keeping the temperature 10~15min；
When temperature is down to 15~30 DEG C, pH to 5~7 is adjusted using pH adjusting agent；
Be eventually adding rose, after mixing evenly stand 12~for 24 hours, obtain cosmetics.
The present invention provides a kind of anti-ageing composition of whitening and cosmetics.The anti-ageing composition of the whitening is extracted by saskatoon
Object, green-tea extract, Gotu Kola P.E and Huai Goat composition.The present invention at least has one of following advantage:
1, the selected natural extract component from Four Plants of ingredient, as alder the effect of whitening of the invention anti-ageing cosmetics
Leaf Chinese bush cherry extract, green-tea extract, Gotu Kola P.E and Huai Goat, can effectively inhibit tyrosine after being applied in combination
Enzymatic activity inhibits the generation of melanin, can significantly removing machine interior free yl resist with stronger antioxidation to whitening
Declining has the function of complementary synergy；
The antioxidant compositions such as saskatoon extract Polyphenols rich in, procyanidine, anthocyanidin, chlorogenic acid,
It removes free radical, anti-inflammatory activity, the formation for the synthesis for safeguarding collagen, improving skin elasticity, inhibiting lipofuscin and senile plaque, reduce
Wrinkle generation, whitening sun protection etc. have significant effect；Green-tea extract can significantly inhibit the activity of tyrosinase, reduce
The generation of melanin can efficiently remove free radical, also have anti-radiation and antianaphylactic effect；Gotu Kola P.E can make skin
It limbers up, helps to solve cutis laxa phenomenon, keep skin smooth flexible, can help that collagen in skin corium is promoted to be formed
It is regenerated with fibrin and eliminates microgroove, kept skin compact smooth, and the increase of fat cell can be inhibited, prevent skin from oedema occur
And obesity；Huai Goat has very strong absorption to ultraviolet light, is a kind of natural broad spectrum sunscreen, and the sophora bud mentions
Taking object also has a variety of effects such as antibacterial, antiviral, anti-aging, anti-inflammatory, antiallergy, anti-oxidant, Red blood streak dispelling.
Composition and cosmetics provided by the invention, it is natural safe and non-stimulating, there is good whitening spot-removing, anti-ageing anti-
Wrinkle, the effect of compact skin, and simultaneously to skin there are also preferable water conservation humidification, sun-proof, Red blood streak dispelling effect, make for a long time
With can make skin that the young state of health be presented.
2, the present invention is free of preservative, but has anti-corrosion effect, and added pungent glycol has excellent broad-spectrum antiseptic living
Property, and Sensiva SC50 can obviously increase the antibiotic effect of pungent glycol, rose has antimicrobial component, passes through synergy
Effect, favorable anti-corrosion effect, and this three also has good skin moisture-keeping performance, and it is highly-safe, it is non-stimulated.
3, the fragrance that the present invention adds is rose, and good water solubility can not only assign the fragrance of product pleasure, but also
Also have keep the skin wet, moisturizing, quick anti-inflammatory, antiallergy, it is antipruritic, delay senescence etc. skin care effects, furthermore Sensiva SC50
Flavouring, fixation and steady fragrant efficiency can also be played.
4, effect ingredient in cosmetics of the invention is composition of plant extracts, natural safety, non-stimulated.
5, product preparation process of the invention is simple, is suitble to industrial production.
Specific embodiment
The invention discloses a kind of anti-ageing composition of whitening and cosmetics, those skilled in the art can be used for reference in this paper
Hold, is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to those skilled in the art
For be it will be apparent that they are considered as being included in the present invention.Method and application of the invention, which has passed through, preferably to be implemented
Example is described, related personnel obviously can not depart from the content of present invention, in spirit and scope to method described herein and
Using being modified or appropriate changes and combinations, carry out implementation and application the technology of the present invention.
In the present invention, saskatoon extract the preparation method is as follows: by after saskatoon clean dry, use pulverizer
It is handled, is crushed to 180~200 mesh, saskatoon powder is taken to be placed in the boiling flask of tool plug, 8~20 times of body is added
The ethyl alcohol that percent concentration is 40%~90% is accumulated, is extracted 2~4 times at 55~85 DEG C, 1~3h, merges each extracting solution every time,
It is filtered with 0.45 μm of miillpore filter, then filtrate decompression concentration is drying to obtain saskatoon extract.
Raw materials used or auxiliary material is available on the market in the anti-ageing composition of whitening provided by the invention and cosmetics.
In the following embodiments, saskatoon extract the preparation method is as follows: by after saskatoon clean dry, use powder
Broken machine is handled, and 180 mesh are crushed to, and saskatoon powder is taken to be placed in the boiling flask of tool plug, and 15 times of volume hundred is added
Dividing specific concentration is 75% ethyl alcohol, is extracted 3 times at 55-85 DEG C, each 2h merges each extracting solution, with 0.45 μm of miillpore filter
It is filtered, then filtrate decompression concentration is drying to obtain saskatoon extract.
Green-tea extract, Gotu Kola P.E and Huai Goat this 3 kinds of extracts are commercially.Wherein, green
Tea extraction, Gotu Kola P.E are purchased from Guangzhou Xu Fan trade Co., Ltd, and Huai Goat is purchased from Guangzhou card sweet smell biotechnology
Co., Ltd.
Below with reference to embodiment, the present invention is further explained:
The preparation of the anti-ageing composition of 1 whitening of embodiment
The anti-ageing composition of the present embodiment whitening is mixed to prepare by following plant extracts:
The preparation of the anti-ageing composition of 2 whitening of embodiment
The anti-ageing composition of the present embodiment whitening is mixed to prepare by following plant extracts:
The preparation of the anti-ageing composition of 3 whitening of embodiment
The anti-ageing composition of the present embodiment whitening is mixed to prepare by following plant extracts:
The anti-ageing efficacy test of whitening of 1 composition of test example
One, external whitening test
1, it test objective: carries out tyrosinase inhibition and compares.
2, test apparatus and reagent
Key instrument: spectrophotometer Spectronic GENESYS-5, Thermo company, the U.S.；
Main agents: tyrosinase (sigma company, the U.S.), other reagents are conventional reagent；The embodiment of the present invention 1 combines
Object, 2 composition of embodiment, 3 composition of embodiment, saskatoon extract, green-tea extract, Gotu Kola P.E and the sophora bud mention
Object is taken, the concentration of preparation is 6%.
3, test method
Phosphate buffer (pH6.8,0.1mol/L), sample liquid, tyrosine solution are separately added into each test tube.It is placed in 37
10min in DEG C water-bath, is then added tyrosinase, reacts 10min in 37 DEG C of water-baths, surveys absorbance value in 475nm, average
Experiment 3 times, is averaged.
It is blank control that experimental system design, which is shown in Table 1, C1, and C2 returns to zero for blank, and S1 is sample cell, and S2 is used for sample tune
Zero.Sample is embodiment 1, embodiment 2, embodiment 3, saskatoon extract, green-tea extract, Gotu Kola P.E and the sophora bud
Extract.
Tyrosinase inhibition rate=(blank control absorbance value-sample absorbance value)/blank control absorbance value ×
100%
1 tyrosinase Inhibition test system of table is loaded table
| Reagent | C1/mL | C2/mL | S1/mL | S2/mL |
| PBS | 2 | 2.5 | 1 | 1.5 |
| Sample | 0 | 0 | 1 | 1 |
| L-tyrosine | 1 | 1 | 1 | 1 |
| Tyrosinase solution | 0.5 | 0 | 0.5 | 0 |
4, test result is shown in Table 2.
The measurement of 2 tyrosinase inhibition rate of table
| Sample | Inhibiting rate (%) |
| Example 1 group closes object | 91.7 |
| 2 composition of embodiment | 93.5 |
| 3 composition of embodiment | 88.1 |
| Saskatoon extract | 78.4 |
| Green-tea extract | 80.6 |
| Gotu Kola P.E | 69.5 |
| Huai Goat | 75.8 |
In vitro test is the results show that 1-3 composition of the embodiment of the present invention has preferable tyrosinase inhibitory activity, inhibition
Rate is higher than each single dose group.
Two, antioxidation in vitro is tested
Experiment purpose: in vitro test, the antioxidant effect of plant extract composition is investigated.
Experimental material: free radical scavenging activity (referred to as: DPPH, Sigma company, the U.S.)；Du800 UV, visible light
Spectrophotometer (Beckman company, the U.S.)；The composition prepared in embodiment 1-3, saskatoon extract, green tea extract
Object, Gotu Kola P.E, Huai Goat, the concentration of preparation are 6%.
Experimental method: taking 0.1mL sample solution, and the DPPH solution that 60 μm of ol/L of 2mL are added mixes, and places 30min, with
Former solvent zeroising, it is Ai that absorbance has been surveyed at 515nm；Measurement absorbance is mixed with method 0.1mL solvent+2mL DPPH solution
Extremely Ac；0.1mL sample solution+2mL solvent mixes measurement absorbance extremely Aj.Its radicals scavenging according to the following formula
Rate.
Clearance rate (%)=[1- (Ai-Aj)/Ac] × 100%
Wherein, contribution of the Aj response sample itself to absorbance；Ai sample is to the absorption values after DPPH effect；Ac is
Absorption of the DPPH in measurement wavelength itself.
Experimental result is as follows:
The experiment of 3 plant extract composition oxidation resistance of table
| Sample | Clearance rate (%) |
| Example 1 group closes object | 90.7 |
| 2 composition of embodiment | 94.8 |
| 3 composition of embodiment | 96.2 |
| Saskatoon extract | 84.9 |
| Green-tea extract | 80.3 |
| Gotu Kola P.E | 78.8 |
| Huai Goat | 82.5 |
Vitro Experimental Results show that 1-3 composition of the embodiment of the present invention has preferable free radical scavenging ability, clearance rate
Higher than each single dose group.
The preparation of the anti-ageing cosmetics of 4 whitening of embodiment
The anti-ageing cosmetics of the whitening of the extract manufactured in the present embodiment containing various plants, including following weight proportion at
Point:
The step of preparing above-mentioned cosmetic composition:
Emollient, cetostearyl alcohol, cetearyl glucoside, Glyceryl stearate citrate are heated to 80 DEG C,
Stirring keeps the temperature 10min, as oily phase to being completely dissolved；
Water, propylene glycol, thickener, pungent glycol, ethyl hexyl glycerol, EDTA-2Na are mixed, 80 DEG C is heated with stirring to, makes it
It is sufficiently dissolved to clear, as water phase；
Then the oil phase is added to the aqueous phase while stirring, then homogeneous 2min keeps the temperature 35min；
When temperature is down to 40 DEG C, sequentially adds moisturizer, saskatoon extract, green-tea extract, centella and extract
Object and Huai Goat, stir evenly, and cool down after keeping the temperature 15min；
When temperature is room temperature, it is slowly added to pH adjusting agent and adjusts pH to 5；It is eventually adding rose, after mixing evenly
Stand 12h to obtain the final product.
The preparation of the anti-ageing cosmetics of 5 whitening of embodiment
The anti-ageing cosmetics of the whitening of the extract manufactured in the present embodiment containing various plants, including following weight proportion at
Point:
The step of preparing above-mentioned cosmetic composition:
Emollient, cetostearyl alcohol, cetearyl glucoside, Glyceryl stearate citrate are heated to 82 DEG C,
Stirring keeps the temperature 8min, as oily phase to being completely dissolved；
Water, propylene glycol, thickener, pungent glycol, ethyl hexyl glycerol, EDTA-2Na are mixed, 82 DEG C is heated with stirring to, makes it
It is sufficiently dissolved to clear, as water phase；
Then the oil phase is added to the aqueous phase while stirring, then homogeneous 3min keeps the temperature 32min；
When temperature is down to 42 DEG C, sequentially adds moisturizer, saskatoon extract, green-tea extract, centella and extract
Object and Huai Goat, stir evenly, and cool down after keeping the temperature 12min；
When temperature is room temperature, it is slowly added to pH adjusting agent and adjusts pH to 6；It is eventually adding rose, after mixing evenly
Stand 20h to obtain the final product.
The preparation of the anti-ageing cosmetics of 6 whitening of embodiment
The anti-ageing cosmetics of the whitening of the extract manufactured in the present embodiment containing various plants, including following weight proportion at
Point:
The step of preparing above-mentioned cosmetic composition:
Emollient, cetostearyl alcohol, cetearyl glucoside, Glyceryl stearate citrate are heated to 85 DEG C,
Stirring keeps the temperature 5min, as oily phase to being completely dissolved；
Water, propylene glycol, thickener, pungent glycol, ethyl hexyl glycerol, EDTA-2Na are mixed, 85 DEG C is heated with stirring to, makes it
It is sufficiently dissolved to clear, as water phase；
Then the oil phase is added to the aqueous phase while stirring, then homogeneous 5min keeps the temperature 30min；
When temperature is down to 45 DEG C, sequentially adds moisturizer, saskatoon extract, green-tea extract, centella and extract
Object and Huai Goat, stir evenly, and cool down after keeping the temperature 10min；
When temperature is room temperature, it is slowly added to pH adjusting agent and adjusts pH to 7；It is eventually adding rose, after mixing evenly
It stands for 24 hours to obtain the final product.
The test of 2 cosmetic effect of test example
One, acute dermal toxicity test
Before test for 24 hours, SD rat back backbone diamond wool is cut, cropping area is no less than the 10% of body surface area.By 2
The rat of kind gender is grouped at random, and every group 6, dosage is grouped into 500,1000,1500,2000,2500mg/kg.It will be of the invention
The cosmetics of embodiment 4 are uniformly applied to rat back, and are covered with oilpaper and 2 layers of gauze, are removed remain with warm water afterwards for 24 hours
Object.The systemic toxicity profiles performance and death condition, the variation including rat skin, hair, eyes and mucous membrane for observing rat, breathe,
The variation of four limbs activity and behavior etc. is observed 1 week.As a result as follows:
Smear that the cosmetics did not occurred being poisoned after 1 week and death condition, skin, hair and eyes do not occur exception, not
Appearance tremble, faint from fear, salivating, diarrhea, it is drowsiness, stupor phenomena such as, illustrate the cosmetics to its skin without any adverse effect.And
And in this test, maximum dose level group is up to 2500mg/kg, rats death does not occur, it may be determined that its median lethal dose is long-range
In 2500mg/kg.So determining that this cosmetics is actually nontoxic.
Acute dermal toxicity test is carried out using the cosmetics of embodiment 5 or 6, does not occur being poisoned after smearing 1 week and dead
Situation, skin, hair and eyes do not occur exception, do not occur trembling, faint from fear, salivate, diarrhea, drowsiness, stupor phenomena such as, say
The bright cosmetics are to its skin without any adverse effect.
Two, Efficiency assessment
Trier is the healthy women voluntarily participated in, is by age divided into 2 groups, and 20-35 years old is A group, and 35-55 years old is B group,
16 people of each group of people, wherein 8 people are professional person.Every trier uses cosmetics one month of the embodiment of the present invention 4, daily
Once.Usage mode are as follows: the cosmetics are uniformly applied to the face after cleaning.Trial effect is observed and investigates, from product perfume
Six type, the sense of product skin, whitening capability, anti-ageing ability, Firm ability, moisture-retaining capacity aspects comment cosmetics of the invention
Valence, the results are shown in Table 4.
The trial effect of all volunteers of table 4
| Project | Well (%) | Generally (%) | Poor (%) |
| Product odor type | 100 | 0 | 0 |
| Product skin sense | 94 | 6 | 0 |
| Whitening capability | 87 | 13 | 0 |
| Anti-ageing ability | 91 | 6 | 3 |
| Firm ability | 88 | 9 | 3 |
| Moisture-retaining capacity | 94 | 6 | 0 |
Result on trial: after one month, all triers do not occur allergic reaction, unanimously think that the product safety is stingless
Swash, have good improvement result to skin quality, whitening spot-removing, anti-ageing anti-wrinkle effect are obvious, also have water conservation humidification, it is sun-proof, dispel it is red
The effect of the trace of blood makes the compact high resilience of skin smooth.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (8)
1. a kind of anti-ageing composition of whitening, which is characterized in that by saskatoon extract, green-tea extract, Gotu Kola P.E
It is formed with Huai Goat；
In parts by weight, the anti-ageing composition of the whitening are as follows: 1~6 part of saskatoon extract, 0.5~5 part of green-tea extract,
1~4 part of Gotu Kola P.E, 0.8~3 part of Huai Goat.
2. the anti-ageing composition of whitening according to claim 1, which is characterized in that the saskatoon extract is Qi Ye Tang
Kerria's alcohol extract.
3. a kind of cosmetics, which is characterized in that mentioned including saskatoon extract, green-tea extract, Gotu Kola P.E, the sophora bud
Take acceptable auxiliary material on object and cosmeceutical；
In parts by weight, effective ingredient consumption in the cosmetics are as follows: 1~6 part of saskatoon extract, green-tea extract 0.5
~5 parts, 1~4 part of Gotu Kola P.E, 0.8~3 part of Huai Goat.
4. cosmetics according to claim 3, which is characterized in that acceptable auxiliary material includes the third two on the cosmeceutical
Alcohol, emollient, moisturizer, thickener, cetostearyl alcohol, cetearyl glucoside, Glyceryl stearate citrate, Xin Gan
Alcohol, Sensiva SC50, rose, EDTA-2Na, pH adjusting agent and water；
In terms of mass percentage, dosage of each component in the cosmetics are as follows:
The pH adjusting agent is the one or two of citric acid or triethanolamine, and the pH value of the cosmetics is 5~7.
5. cosmetics according to claim 4, which is characterized in that the emollient be wheat-germ oil, macadimia nut oil,
In jojoba oil, avocado oil, shea butter, Sweet Almond Oil, Semen Coicis oil, rice bran oil, safflower oil or myristyl alcohol myristinate
One or more.
6. cosmetics according to claim 4, which is characterized in that the moisturizer is ethoxy urea, ceramide, transparent
One or more of matter acid sodium, levulan, allantoin, reed fragrant plant oil, D-sorbite or glycine betaine.
7. cosmetics according to claim 4, which is characterized in that the thickener be carbomer, xanthan gum, seaweed glue,
One or more of guar gum, chitosan, Arabic gum or tara gum.
8. the preparation method of cosmetics as described in any one of claim 4 to 7, which comprises the steps of:
Emollient, cetostearyl alcohol, cetearyl glucoside, Glyceryl stearate citrate are mixed, it is heated to 80~
85 DEG C, stirring keeps the temperature 5~10min, obtains oily phase to being completely dissolved；
Water, propylene glycol, thickener, pungent glycol, ethyl hexyl glycerol, EDTA-2Na are mixed, 80~85 DEG C is heated with stirring to, makes it
Sufficiently dissolution, obtains water phase；
The oil is mutually mixed with the water phase, then 2~5min of homogeneous keeps the temperature 30~35min；
When temperature is down to 40~45 DEG C, be added moisturizer, saskatoon extract, green-tea extract, Gotu Kola P.E and
Huai Goat stirs evenly, and cools down after keeping the temperature 10~15min；
When temperature is down to 15~30 DEG C, pH to 5~7 is adjusted using pH adjusting agent；
Be eventually adding rose, after mixing evenly stand 12~for 24 hours, obtain the cosmetics.
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| CN108553390A (en) * | 2018-07-01 | 2018-09-21 | 佛山市芊茹化妆品有限公司 | A kind of preparation method and applications of compound skin-whitening composition |
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| CN110585095A (en) * | 2019-08-05 | 2019-12-20 | 黄秀英 | Cell-based anti-aging composition and preparation method thereof |
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| CN112675101A (en) * | 2021-02-07 | 2021-04-20 | 上海柔素生物科技有限公司 | Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof |
| CN113171309B (en) * | 2021-05-19 | 2022-08-12 | 成都农业科技中心 | Whitening and moisturizing cosmetic composition containing phloretin as well as preparation and application thereof |
| CN113786371A (en) * | 2021-07-05 | 2021-12-14 | 中国科学院烟台海岸带研究所 | Composition for preparing blueberry seaweed mask, mask and preparation method |
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