WO2015010371A1

WO2015010371A1 - Serum used for treatment of acne hyperpigmentation spot and for whitening

Info

Publication number: WO2015010371A1
Application number: PCT/CN2013/085011
Authority: WO
Inventors: 陈俊杰
Original assignee: 彭海英
Priority date: 2013-07-23
Filing date: 2013-10-11
Publication date: 2015-01-29
Also published as: CN103432063B; CN103432063A

Abstract

Provided in the present invention is a serum used for treatment of an acne hyperpigmentation spot and for whitening. The serum comprises constituents of the following parts by mass: 1 to 3 parts of a trace element composition, 3 to 5 parts of collagen, 25 to 35 parts of hydrogen-rich and oxygen-rich water, 0.1 to 0.5 parts of hyaluronic acid, and 1 to 5 parts of a superoxide dismutase, where the trace element composition is one or two between zinc gluconate and sodium selenite, and the hydrogen-rich and oxygen-rich water is a mixture of hydrogen-rich water and oxygen-rich water. The superoxide dismutase used by the present invention has a specific activity of 1000 to 2000 IU/mg. The serum provided in the present invention is of reduced irritativeness, is free of toxic side effects, allows for effective elimination of acne and fading of a hyperpigmentation spot, and at the same time provides a whitening effect.

Description

Essence for treating acne pigmentation and whitening

The invention relates to an essence having the functions of treating acne, diminishing pigmentation spots and having whitening effect.

Background technique

Acne is a skin disease, also known as acne, acne, hemorrhoids or facial sores. It is a common skin that develops during puberty, oily skin, eats fat and sugary foods, stimulates food because of day or night or work nature. disease. The patient is over-secreted by sebaceous glands, and a large amount of stratum corneum is detached. When mixed with grease and dirt, the pores are blocked, which causes redness and inflammation of the hair follicle. In severe cases, it also causes pigment cell proliferation, leaving pigment spots that are difficult to eliminate, and affects the appearance of patients. At present, cosmetics for treating pigmentation caused by acne and acne are mostly used by adding chemical fungicides, hormones, etc., although these components can sterilize or eliminate inflammation in a short time, but are highly irritating to the skin. Long-term use will increase the patient's skin burden, and may even cause skin redness, suppuration or pain, and some will stimulate the further proliferation of pigment cells and aggravate pigmentation spots. How to develop a safer, gentler and more effective skin care product for treating acne and diminishing pigmentation spots has become one of the urgent problems in the field.

Summary of the invention

In order to make up for the deficiencies of the prior art, the object of the present invention is to provide a topical serum which has little irritation, has no toxic side effects, can effectively eliminate acne and dilute pigmentation spots, and has a whitening effect.

The invention solves the technical problems thereof, and the technical solutions adopted are as follows:

An essence for treating acne pigmentation and whitening, characterized in that the essence contains the following components by mass: 1 to 3 parts of the trace element composition, 3 to 5 parts of the collagen, and rich in hydrogen 25 to 35 parts of oxygen water, 0.1 to 0.5 parts of hyaluronic acid, and 1 to 5 parts of superoxide dismutase, wherein the trace element composition is one or two of zinc gluconate and sodium selenite, and is rich in hydrogen. The oxygen-enriched water is a mixture of hydrogen-rich water and oxygen-enriched water. The superoxide dismutase used in the present invention has a specific activity of 1000 to 2000 IU/mg.

The trace element composition is a combination of zinc gluconate and sodium selenite according to a mass ratio (5-10):1. The hydrogen-rich oxygen-enriched water is a combination of hydrogen-rich water and oxygen-enriched water having a mass ratio of 1: (1-3).

The hydrogen-rich water has a hydrogen (in terms of hydrogen molecules) concentration of 0.9 to 1.2 ppm, and the oxygen-enriched water contains a dissolved oxygen concentration of 20 to 50 ppm.

Preferably, the essence further comprises 5 to 10 parts by mass of a traditional Chinese medicine composition, and the traditional Chinese medicine composition is obtained by extracting the components of the following medicinal material formula: 1 to 5 parts by mass of hibiscus, 2 to 5 masses of sarcophagus Parts, peony root skin 1~3 parts by mass, 2 to 6 parts by mass of licorice and 1 to 4 parts by mass of white peony.

Further preferably, the medicinal material is formulated as: 3 parts by mass of hibiscus, 4 parts by mass of sarcophagus, 2 parts by mass of peony root, 4 parts by mass of licorice, and 2 parts by mass of peony.

Preferably, the traditional Chinese medicine composition is prepared according to the following extraction process:

1) Weigh each medicinal material according to the medicinal material formula, crush the grass stone silkworm, peony root bark and white peony, mix it with hibiscus and licorice, add deionized water for 4~8 hours at room temperature, and add water to the total quality of the medicinal material. 4~6 times;

2) After heating and boiling at 50 to 60 ° C for 3 to 5 hours, the obtained extract is filtered, and the obtained filtrate is a traditional Chinese medicine composition.

The following describes the components used in the technical solution of the present invention:

Collagen: Collagen (collagen) is a biological polymer substance, a white, opaque, unbranched fibrous protein. It can replenish the nutrients needed in all layers of the skin, enhance the collagen activity in the skin, and have certain effects on moisturizing the skin, delaying aging, beauty, wrinkle and hair growth.

Hydrogen-rich water: Also known as Hydrogen Water, it is a transliteration of Japanese. Hydrogen itself is one of the best natural antioxidants, so the water added with hydrogen has a strong reducing function. It can neutralize active oxygen (free radicals) in the body's blood and cells. Modern medicine believes that active hydrogen can effectively remove free radicals in the body. Hydrogen-rich water has more antioxidant properties than all known human antioxidants such as vitamin C, carrots, lecithin, etc., for allergic dermatitis, constipation, hypertension, diabetes, cancer. All kinds of symptoms caused by free radicals have a strong preventive effect. Hydrogen-rich water promotes metabolism and allows each cell to maintain a healthy state, remove body rust and delay aging. The preparation method of hydrogen-rich water has been a relatively mature technology, and a method for preparing hydrogen-rich water is described in Chinese Patent Application Publication No. CN102408147A.

Oxygen-enriched water: refers to water containing more oxygen in which the dissolved oxygen concentration in water is higher than that of ordinary water. By directly supplying the water containing a high concentration of dissolved oxygen to the skin, it can promote the respiratory cells of the skin cells to activate the cells, improve the moisturizing ability, delay the aging, promote the renewal of the skin, and thereby promote the discharge of melanin produced in the skin, thereby displaying Whitening effect. Oxygen-enriched water is a natural anti-microbial preservative and oxygen booster that promotes skin metabolism and promotes overall skin health. The preparation method of the oxygen-enriched water is a well-established technique, and the preparation method of the oxygen-enriched water is described in the Chinese Patent Application Publication No. CN1200355A and the Chinese Patent Application Publication No. WO102641223A.

Hyaluronic acid: Hyaluronic acid not only has the function of maintaining skin elasticity, but also locks a lot of water molecules, which has moisturizing and lubricating effect on tissues, making the skin full and young and elastic, but as the age increases, the rate of hyaluronic acid loss is faster than the growth rate. The skin will gradually become dehydrated, lose its luster and elasticity, and wrinkles and other aging phenomena will appear over time. Superoxide dismutase (SOD): SOD is a strong redox agent that can react with oxygen free radicals in the body, so that human cell repair and gene organization are not damaged. Anti-aging is constantly supplemented by SOD. The effect of superoxide dismutase (SOD) is a free radical scavenger that scavenges free radicals 02- (superoxide anion radicals), while 02- is cytotoxic, can cause lipid peroxidation, damage cell membranes, cause inflammation , tumors and autoimmune diseases, and may cause the body to age. SOD is a powerful free radical scavenger that inhibits pigment cell deposition and has anti-aging, immune regulation and anti-radiation effects.

Hibiscus: It is rich in vitamin C, iron, calcium, zinc, selenium and other trace elements, and contains flavonoid active compounds and mucus. The hibiscus extract has the functions of moisturizing, anti-oxidation and scavenging free radicals, and can inhibit Staphylococcus aureus and Salmonella typhi.

Grass stone silkworm: Also known as silver bar, it is a specialty of Yanshi City, Henan Province, China. Its shape and taste are similar to those of green bean sprouts. Grass stone Silkworm is rich in sugar, phenols, vitamin c, crude protein, amino acids, organic acids, etc. It has a unique effect on softening blood vessels, lowering blood and improving blood circulation.

Peony root bark: dry root bark of peony family of Ranunculaceae. The peony phenol and other glycoside components have anti-inflammatory effects; the methanol extract of peony bark has the effect of inhibiting platelets; peony phenol has central inhibition of sedation, cooling, antipyretic, analgesic, antispasmodic and anti-arterial Atherosclerosis, diuretic, anti-ulcer and so on. The extract of peony root bark has anti-bacterial, anti-inflammatory, acne and whitening effects.

Licorice: Sweet and flat. Licorice also has anti-inflammatory and anti-allergic effects, which can protect the inflamed throat and tracheal mucosa. Licorice extract and glycyrrhizic acid have a detoxifying effect similar to glucuronic acid to certain poisons. Licorice can clear away heat and detoxify, moisten the lungs and relieve cough, and reconcile various medicinal properties; it has anti-inflammatory, anti-viral, liver-protecting and detoxifying functions and enhances immune function. Relieve the toxicity and potency of the drug. The flavonoids of licorice have anti-inflammatory, antispasmodic and anti-acid effects; the effective component of detoxification is glycyrrhizin, and the detoxification mechanism is the adsorption of glycyrrhizin on poisons.

White peony: It has whitening and anti-inflammatory properties, protects against UV damage and promotes skin metabolism.

The technical solution adopted by the invention has the following beneficial effects:

(1) In one embodiment of the present invention, a trace element composition, collagen, hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase is added to the essence, and these components are compatible with a specific quality, and are suitable for acne It has a good therapeutic effect, has a lightening effect on the sun stains, and at the same time plays a whitening effect. A trace element composition formed by a combination of zinc gluconate and sodium selenite, which can supplement zinc and selenium to the skin. Zinc has a role in coordinating immune responses. Zinc is involved in the synthesis of various enzymes such as carbonic anhydrase, alkaline phosphatase, and DNA polymerase, and increases the repair of wound tissue. Selenium is an effective and comprehensive antioxidant that dramatically delays cell aging while simultaneously preventing collagen denaturation, which increases collagen synthesis and reduces its loss. Current research shows that selenium has an antioxidant effect, Protects the molecular damage site by protecting the cell membrane structure; Selenium can promote various metabolic activities in the body. Selenium is a normal component of muscle and an essential component of glutathione peroxidase. Selenium is antagonistic and reduced in the human body. A variety of heavy metal toxicity, selenium can stimulate the production of immunoglobulins and antibodies, improve the body's immune function. The hydrogen-rich and oxygen-rich water formed by the mixture of hydrogen-rich water and oxygen-enriched water is rich in active hydrogen and dissolved oxygen, promotes metabolism, enables each cell to maintain a healthy state automatically, effectively removes free radicals in the body, and promotes skin cells. Breathe and activate cells, improve moisturizing ability, promote skin renewal and discharge melanin produced in the skin. Formulated with collagen, hyaluronic acid and superoxide dismutase to replenish moisture and collagen to the skin. SOD acts as a powerful free radical scavenger and inhibits pigment cell deposition. In this scheme, the combination of trace elements, collagen, hydrogen-rich oxygen-enriched water, hyaluronic acid and superoxide dismutase can improve the body's immunity, repair wounds, activate cells, achieve acne, and promote Cell metabolism and inhibition of melanin deposition, to achieve the effect of lightening pigmentation spots. Practice has proved that after 3 weeks of continuous use, the efficiency of acne can reach 90%, the cure rate can reach 70-80%, the effective rate of stain can reach 89%, and the cure rate of stain can reach 65~78%;

(2) In a preferred embodiment of the present invention, a traditional Chinese medicine composition is further added to the essence, which is formed by combining a certain amount of Chinese medicinal materials such as hibiscus, grass stone, peony root, licorice and white peony according to a certain quality. It can replenish the essence with natural active ingredients to enhance the effect of acne and fade spots. Hibiscus contains a variety of trace elements, which make the extracts richer trace elements from different sources. These trace elements from different sources work synergistically to accelerate the repair of damaged cells, improve the body immunity and resist external Environmental intrusion. By adding a traditional Chinese medicine composition obtained by extracting hibiscus, grass stone silkworm, peony root bark, licorice, and white peony to the essence, the extract is further supplemented with plant-derived vitamin C, flavonoid active compound, mucilage. Rich in active substances such as phenols, crude protein, amino acids, organic acids, peony phenol, glycyrrhizic acid, etc., not only can further enhance anti-oxidation, antibacterial and antibacterial effects, but also replenish skin nutrition, activate skin, whiten and fade skin Spot. With this preferred solution, the time to effect can be shortened. Practice has proved that the essence prepared by the preferred solution can effectively treat acne and dilute pigmentation after 2 weeks of continuous use, and the acne can reach 96%, and the cure rate can reach 78-89%. The effective rate can reach 95%, and the stain cure rate can reach 80~90%.

(3) The essence provided by the invention has good safety and no toxic and side effects.

detailed description

The present invention will be further described in detail below with reference to the embodiments.

Example 1

An essence for treating acne pigmentation and whitening

(1) Weigh each component according to the following formula: 3 parts of trace element composition, 5 parts of collagen, hydrogen-rich oxygen-enriched water 35 parts, 0.5 parts of hyaluronic acid and 5 parts of superoxide dismutase, wherein the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 10:1, and the hydrogen-rich oxygen-rich water is hydrogen-rich water and The oxygen-enriched water is a mixture having a mass ratio of 1:3, the hydrogen-rich water has a hydrogen concentration of 1.2 ppm, and the oxygen-enriched water has a dissolved oxygen concentration of 50 ppm. The specific activity of the superoxide dismutase used was 2000 IU/mg.

(2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;

(3) Pour hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase into another sterilized container, stir until the components are completely dissolved and mixed, pour the substance in step 2 into it, and continue Stir until completely clear solution, and finally sterilize the filling.

Example 2:

An essence for treating acne pigmentation and whitening

(1) Weigh each component according to the following formula: 1 part of trace element composition, 3 parts of collagen, 25 parts of hydrogen-rich oxygen-enriched water, 0.1 part of hyaluronic acid, 1 part of superoxide dismutase, wherein, trace element composition It is a combination of zinc gluconate and sodium selenite according to a mass ratio of 5:1. The hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, and the hydrogen-rich water has a hydrogen concentration of 0.9. Ppm, oxygen-enriched water contains a dissolved oxygen concentration of 20 ppm. The specific activity of the superoxide dismutase used was 1000 IU/mg.

Example 3:

An essence for treating acne pigmentation and whitening

(1) Weigh each component according to the following formula: 2 parts of trace element composition, 4 parts of collagen, 30 parts of hydrogen-rich oxygen-enriched water, 0.3 parts of hyaluronic acid, 3 parts of superoxide dismutase, among which, trace element composition It is a combination of zinc gluconate and sodium selenite according to a mass ratio of 7:1. The hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water in a mass ratio of 1:2, and the hydrogen-rich water has a hydrogen concentration of l. .Oppm, oxygen-enriched water contains a dissolved oxygen concentration of 30 ppm. The specific activity of the superoxide dismutase used was 1500 IU/mg.

(3) Pour hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase into another sterilized container, stir until the components are completely dissolved and mixed, pour the substance in step 2 into it, and continue Stir until completely clear solution, and finally sterilize the filling. Example 4:

An essence for treating acne pigmentation and whitening

(1) Each component was weighed according to the following formula: 1 part of trace element composition, 3 parts of collagen, 25 parts of hydrogen-rich oxygen-enriched water, 0.1 part of hyaluronic acid, 1 part of superoxide dismutase, and 5 parts of traditional Chinese medicine composition. Wherein, the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 5:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water. The hydrogen concentration was 0.9 ppm, and the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm. The specific activity of the superoxide dismutase used was 1000 IU/mg.

(3) Pour hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase, and traditional Chinese medicine composition into another sterilized container, stir until the components are completely dissolved and mixed, and pour the substance in step 2 into Among them, the components are continuously stirred and mixed, so that the components are completely dissolved, and finally, the sterilization is filled.

The traditional Chinese medicine composition used was prepared as follows:

a: Weigh each component according to the following medicinal formula: 1 part by mass of hibiscus, 2 parts by mass of sarcophagus, 1 part by mass of peony root, 2 parts by weight of licorice, and 1 part by mass of peony;

b: After crushing the grass stone, peony root and white peony, mix it with hibiscus and licorice, add deionized water to soak at room temperature.

4 hours, the amount of water added is 4 times the total mass of the medicine;

c: After heating and boiling at 50 to 60 ° C for 3 hours, the resulting extract was filtered.

Example 5:

An essence for treating acne pigmentation and whitening

(1) Weigh each component according to the following formula: Trace element composition 1 part, collagen 3 parts, hydrogen-rich oxygen-enriched water

25 parts, 0.1 parts of hyaluronic acid, 1 part of superoxide dismutase, and 8 parts of traditional Chinese medicine composition. Wherein, the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 5:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water. The hydrogen concentration was 0.9 ppm, and the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm. The specific activity of the superoxide dismutase used was 1000 IU/mg.

(3) Pour hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase, and traditional Chinese medicine composition into another sterilized container, stir until the components are completely dissolved and mixed, and pour the substance in step 2 into Among them, and constantly stirring until completely transparent solution, and finally sterilized filling.

The traditional Chinese medicine composition used was prepared as follows:

a: Weigh each component according to the following herbal formula: 5 parts by weight of hibiscus, 5 parts by weight of grass stone, and peony root 3 Parts by mass, 6 parts by mass of licorice, 4 parts by mass of white peony;

b: crushing grass stone, peony root and white peony, mixing with hibiscus and licorice, adding deionized water for 8 hours at room temperature, the added water is 6 times of the total mass of the medicinal material;

c: After heating and boiling at 50 to 60 ° C for 5 hours, the resulting extract was filtered.

Example 6:

An essence for treating acne pigmentation and whitening

(1) Weigh each component according to the following formula: 2 parts of trace element composition, 4 parts of collagen, 30 parts of hydrogen-rich oxygen-enriched water, 0.3 parts of hyaluronic acid, 3 parts of superoxide dismutase, 10 parts of traditional Chinese medicine composition, Wherein, the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 7:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water in a mass ratio of 1:2, hydrogen-rich water. The hydrogen concentration is 1.0 ppm, and the oxygen-enriched water contains a dissolved oxygen concentration of 30 ppm. The specific activity of the superoxide dismutase used was 1500 IU/mg.

The traditional Chinese medicine composition used was prepared as follows:

a: Weigh each component according to the following medicinal formula: 3 parts by mass of hibiscus, 4 parts by mass of phytolith, 2 parts by mass of peony root, 4 parts by weight of licorice, and 2 parts by weight of peony;

b: The grass stone silkworm, the peony root and the white peony are crushed, mixed with hibiscus and licorice, and added with deionized water for 6 hours at room temperature, and the added water is 5 times of the total mass of the medicinal material;

c: After heating and boiling at 50 to 60 ° C for 4 hours, the resulting extract was filtered.

Performance test:

For each of the examples, 50 people were selected for trial. The tester's inclusion criteria were that they had acne or had pigmentation spots on the face due to the previous occurrence of blue acne.

How to use: Apply the essence to the affected area, once a day in the morning and evening.

Efficacy evaluation criteria: After the user reduced acne, inflammation decreased, red lightened to be effective; acne completely disappeared to cure; the pigmentation became less effective and less effective; the stain disappeared completely to cure.

Trial results: The users of Examples 1~3 have an effective rate of 90% after 3 weeks of continuous trial, the cure rate is 70~80%, the stain efficiency is 89%, and the stain cure rate is 65~78%; The users of Examples 4 to 6 had an effective rate of 96% after 2 weeks of continuous trial, a cure rate of 78 to 89%, and an effective rate of 95%. The cure rate is 80-90%.

A typical example is introduced:

Wanmou, 25 years old, network engineer, needs to face the computer for a long time. The face often has acne and the face is dull. After using the product of the first embodiment of the invention for 3 weeks, the acne disappears and the skin is more moist and tender. White.

Liu, 17 years old, student, due to the pressure of further study, irregular schedule, face full of acne, several spots on his face, after using the product of Example 5 of the present invention for 2 weeks, most of the acne All disappeared, the stains were noticeably faded, and the skin appeared white. The above is only the preferred embodiment of the present invention, and is not intended to limit the present invention in any way. Therefore, any of the above embodiments can be made according to the technical essence of the present invention without departing from the technical solution of the present invention. Simple modifications, equivalent changes and modifications are still within the scope of the technical solutions of the present invention.

Claims

claims

1. An essence for treating acne, pigmentation, spots and whitening. It is characterized in that the essence contains the following components by mass: 1 to 3 parts of trace element composition, 3 to 5 parts of collagen, rich 25 to 35 parts of hydrogen-enriched water, 0.1 to 0.5 parts of hyaluronic acid, and 1 to 5 parts of superoxide dismutase, wherein the trace element composition is one or two of zinc gluconate and sodium selenite, Hydrogen-rich and oxygen-rich water is a mixture of hydrogen-rich water and oxygen-rich water.

2. The essence for treating acne pigmentation spots and whitening according to claim 1, characterized in that the trace element composition is zinc gluconate and sodium selenite in a mass ratio of (5 to 10) : 1 combination.

3. The essence for treating acne pigmentation spots and whitening according to claim 1, characterized in that the hydrogen-rich and oxygen-rich water is hydrogen-rich water and hydrogen-rich water with a mass ratio of 1: (1-3) A combination of oxygen and water.

4. The essence for treating acne pigmentation spots and whitening according to claim 1, characterized in that the hydrogen-rich water has a hydrogen concentration of 0.9~1.2ppm, and the oxygen-rich water has dissolved oxygen The concentration is 20~50ppm.

5. The essence for treating acne pigmentation spots and whitening according to any one of claims 1 to 4, characterized in that the essence also contains 5 to 10 parts by mass of a traditional Chinese medicine composition, and the traditional Chinese medicine The composition is prepared by extracting each component of the following medicinal material formula: 1 to 5 parts by mass of hibiscus flower, 2 to 5 parts by mass of caddis fly, 1 to 3 parts by mass of peony root bark, 2 to 6 parts by mass of licorice, and 1 part of white tuckahoe. ~4 parts by mass.

6. The essence for treating acne pigmentation spots and whitening according to claim 5, characterized in that the medicinal material formula is: 3 parts by mass of hibiscus flower, 4 parts by mass of caddisfly, 2 parts by mass of peony root bark. parts by mass, 4 parts by mass of licorice, and 2 parts by mass of Poria cocos.

7. The essence for treating acne pigmentation spots and whitening according to claim 5, characterized in that the traditional Chinese medicine composition is prepared according to the following extraction process:

1) Weigh each medicinal material according to the medicinal material formula, crush the caddisfly, peony root bark and white tuckahoe into powder, mix with hibiscus and licorice, add deionized water and soak at room temperature for 4 to 8 hours. The amount of deionized water added The amount of water is 4-6 times the total mass of medicinal materials;

2) Then heat and cook at 60~70°C for 3~5 hours, filter and retain the filtrate.