WO2015010371A1 - Serum used for treatment of acne hyperpigmentation spot and for whitening - Google Patents
Serum used for treatment of acne hyperpigmentation spot and for whitening Download PDFInfo
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- WO2015010371A1 WO2015010371A1 PCT/CN2013/085011 CN2013085011W WO2015010371A1 WO 2015010371 A1 WO2015010371 A1 WO 2015010371A1 CN 2013085011 W CN2013085011 W CN 2013085011W WO 2015010371 A1 WO2015010371 A1 WO 2015010371A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
Definitions
- the invention relates to an essence having the functions of treating acne, diminishing pigmentation spots and having whitening effect.
- Acne is a skin disease, also known as acne, acne, hemorrhoids or facial sores. It is a common skin that develops during puberty, oily skin, eats fat and sugary foods, stimulates food because of day or night or work nature. disease. The patient is over-secreted by sebaceous glands, and a large amount of stratum corneum is detached. When mixed with grease and dirt, the pores are blocked, which causes redness and inflammation of the hair follicle. In severe cases, it also causes pigment cell proliferation, leaving pigment spots that are difficult to eliminate, and affects the appearance of patients.
- cosmetics for treating pigmentation caused by acne and acne are mostly used by adding chemical fungicides, hormones, etc., although these components can sterilize or eliminate inflammation in a short time, but are highly irritating to the skin.
- Long-term use will increase the patient's skin burden, and may even cause skin redness, suppuration or pain, and some will stimulate the further proliferation of pigment cells and aggravate pigmentation spots.
- How to develop a safer, gentler and more effective skin care product for treating acne and diminishing pigmentation spots has become one of the urgent problems in the field.
- the object of the present invention is to provide a topical serum which has little irritation, has no toxic side effects, can effectively eliminate acne and dilute pigmentation spots, and has a whitening effect.
- An essence for treating acne pigmentation and whitening characterized in that the essence contains the following components by mass: 1 to 3 parts of the trace element composition, 3 to 5 parts of the collagen, and rich in hydrogen 25 to 35 parts of oxygen water, 0.1 to 0.5 parts of hyaluronic acid, and 1 to 5 parts of superoxide dismutase, wherein the trace element composition is one or two of zinc gluconate and sodium selenite, and is rich in hydrogen.
- the oxygen-enriched water is a mixture of hydrogen-rich water and oxygen-enriched water.
- the superoxide dismutase used in the present invention has a specific activity of 1000 to 2000 IU/mg.
- the trace element composition is a combination of zinc gluconate and sodium selenite according to a mass ratio (5-10):1.
- the hydrogen-rich oxygen-enriched water is a combination of hydrogen-rich water and oxygen-enriched water having a mass ratio of 1: (1-3).
- the hydrogen-rich water has a hydrogen (in terms of hydrogen molecules) concentration of 0.9 to 1.2 ppm, and the oxygen-enriched water contains a dissolved oxygen concentration of 20 to 50 ppm.
- the essence further comprises 5 to 10 parts by mass of a traditional Chinese medicine composition
- the traditional Chinese medicine composition is obtained by extracting the components of the following medicinal material formula: 1 to 5 parts by mass of hibiscus, 2 to 5 masses of sarcophagus Parts, peony root skin 1 ⁇ 3 parts by mass, 2 to 6 parts by mass of licorice and 1 to 4 parts by mass of white peony.
- the medicinal material is formulated as: 3 parts by mass of hibiscus, 4 parts by mass of sarcophagus, 2 parts by mass of peony root, 4 parts by mass of licorice, and 2 parts by mass of peony.
- the traditional Chinese medicine composition is prepared according to the following extraction process:
- Collagen is a biological polymer substance, a white, opaque, unbranched fibrous protein. It can replenish the nutrients needed in all layers of the skin, enhance the collagen activity in the skin, and have certain effects on moisturizing the skin, delaying aging, beauty, wrinkle and hair growth.
- Hydrogen-rich water Also known as Hydrogen Water, it is a transliteration of Japanese. Hydrogen itself is one of the best natural antioxidants, so the water added with hydrogen has a strong reducing function. It can neutralize active oxygen (free radicals) in the body's blood and cells. Modern medicine believes that active hydrogen can effectively remove free radicals in the body. Hydrogen-rich water has more antioxidant properties than all known human antioxidants such as vitamin C, carrots, lecithin, etc., for allergic dermatitis, constipation, hypertension, diabetes, cancer. All kinds of symptoms caused by free radicals have a strong preventive effect. Hydrogen-rich water promotes metabolism and allows each cell to maintain a healthy state, remove body rust and delay aging. The preparation method of hydrogen-rich water has been a relatively mature technology, and a method for preparing hydrogen-rich water is described in Chinese Patent Application Publication No. CN102408147A.
- Oxygen-enriched water refers to water containing more oxygen in which the dissolved oxygen concentration in water is higher than that of ordinary water. By directly supplying the water containing a high concentration of dissolved oxygen to the skin, it can promote the respiratory cells of the skin cells to activate the cells, improve the moisturizing ability, delay the aging, promote the renewal of the skin, and thereby promote the discharge of melanin produced in the skin, thereby displaying Whitening effect.
- Oxygen-enriched water is a natural anti-microbial preservative and oxygen booster that promotes skin metabolism and promotes overall skin health.
- the preparation method of the oxygen-enriched water is a well-established technique, and the preparation method of the oxygen-enriched water is described in the Chinese Patent Application Publication No. CN1200355A and the Chinese Patent Application Publication No. WO102641223A.
- Hyaluronic acid not only has the function of maintaining skin elasticity, but also locks a lot of water molecules, which has moisturizing and lubricating effect on tissues, making the skin full and young and elastic, but as the age increases, the rate of hyaluronic acid loss is faster than the growth rate. The skin will gradually become dehydrated, lose its luster and elasticity, and wrinkles and other aging phenomena will appear over time.
- SOD superoxide dismutase
- Hibiscus It is rich in vitamin C, iron, calcium, zinc, selenium and other trace elements, and contains flavonoid active compounds and mucus.
- the hibiscus extract has the functions of moisturizing, anti-oxidation and scavenging free radicals, and can inhibit Staphylococcus aureus and Salmonella typhi.
- Grass stone silkworm Also known as silver bar, it is a specialty of Yanshi City, Henan province, China. Its shape and taste are similar to those of green bean sprouts.
- Grass stone Silkworm is rich in sugar, phenols, vitamin c, crude protein, amino acids, organic acids, etc. It has a unique effect on softening blood vessels, lowering blood and improving blood circulation.
- Peony root bark dry root bark of peony family of Ranunculaceae.
- the peony phenol and other glycoside components have anti-inflammatory effects;
- the methanol extract of peony bark has the effect of inhibiting platelets;
- peony phenol has central inhibition of sedation, cooling, antipyretic, analgesic, antispasmodic and anti-arterial Atherosclerosis, diuretic, anti-ulcer and so on.
- the extract of peony root bark has anti-bacterial, anti-inflammatory, acne and whitening effects.
- Licorice Sweet and flat. Licorice also has anti-inflammatory and anti-allergic effects, which can protect the inflamed throat and tracheal mucosa. Licorice extract and glycyrrhizic acid have a detoxifying effect similar to glucuronic acid to certain poisons. Licorice can clear away heat and detoxify, moisten the lungs and relieve cough, and reconcile various medicinal properties; it has anti-inflammatory, anti-viral, liver-protecting and detoxifying functions and enhances immune function. Relieve the toxicity and potency of the drug.
- the flavonoids of licorice have anti-inflammatory, antispasmodic and anti-acid effects; the effective component of detoxification is glycyrrhizin, and the detoxification mechanism is the adsorption of glycyrrhizin on poisons.
- White peony It has whitening and anti-inflammatory properties, protects against UV damage and promotes skin metabolism.
- a trace element composition collagen, hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase is added to the essence, and these components are compatible with a specific quality, and are suitable for acne It has a good therapeutic effect, has a lightening effect on the sun stains, and at the same time plays a whitening effect.
- a trace element composition formed by a combination of zinc gluconate and sodium selenite, which can supplement zinc and selenium to the skin.
- Zinc has a role in coordinating immune responses. Zinc is involved in the synthesis of various enzymes such as carbonic anhydrase, alkaline phosphatase, and DNA polymerase, and increases the repair of wound tissue.
- Selenium is an effective and comprehensive antioxidant that dramatically delays cell aging while simultaneously preventing collagen denaturation, which increases collagen synthesis and reduces its loss.
- Current research shows that selenium has an antioxidant effect, Protects the molecular damage site by protecting the cell membrane structure; Selenium can promote various metabolic activities in the body.
- Selenium is a normal component of muscle and an essential component of glutathione peroxidase.
- Selenium is antagonistic and reduced in the human body. A variety of heavy metal toxicity, selenium can stimulate the production of immunoglobulins and antibodies, improve the body's immune function.
- the hydrogen-rich and oxygen-rich water formed by the mixture of hydrogen-rich water and oxygen-enriched water is rich in active hydrogen and dissolved oxygen, promotes metabolism, enables each cell to maintain a healthy state automatically, effectively removes free radicals in the body, and promotes skin cells. Breathe and activate cells, improve moisturizing ability, promote skin renewal and discharge melanin produced in the skin. Formulated with collagen, hyaluronic acid and superoxide dismutase to replenish moisture and collagen to the skin. SOD acts as a powerful free radical scavenger and inhibits pigment cell deposition.
- the combination of trace elements, collagen, hydrogen-rich oxygen-enriched water, hyaluronic acid and superoxide dismutase can improve the body's immunity, repair wounds, activate cells, achieve acne, and promote Cell metabolism and inhibition of melanin deposition, to achieve the effect of lightening pigmentation spots.
- the efficiency of acne can reach 90%
- the cure rate can reach 70-80%
- the effective rate of stain can reach 89%
- the cure rate of stain can reach 65 ⁇ 78%
- a traditional Chinese medicine composition is further added to the essence, which is formed by combining a certain amount of Chinese medicinal materials such as hibiscus, grass stone, peony root, licorice and white peony according to a certain quality. It can replenish the essence with natural active ingredients to enhance the effect of acne and fade spots.
- Hibiscus contains a variety of trace elements, which make the extracts richer trace elements from different sources. These trace elements from different sources work synergistically to accelerate the repair of damaged cells, improve the body immunity and resist external Environmental intrusion.
- the extract is further supplemented with plant-derived vitamin C, flavonoid active compound, mucilage. Rich in active substances such as phenols, crude protein, amino acids, organic acids, peony phenol, glycyrrhizic acid, etc., not only can further enhance anti-oxidation, antibacterial and antibacterial effects, but also replenish skin nutrition, activate skin, whiten and fade skin Spot. With this preferred solution, the time to effect can be shortened.
- the essence prepared by the preferred solution can effectively treat acne and dilute pigmentation after 2 weeks of continuous use, and the acne can reach 96%, and the cure rate can reach 78-89%.
- the effective rate can reach 95%, and the stain cure rate can reach 80 ⁇ 90%.
- each component according to the following formula: 3 parts of trace element composition, 5 parts of collagen, hydrogen-rich oxygen-enriched water 35 parts, 0.5 parts of hyaluronic acid and 5 parts of superoxide dismutase, wherein the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 10:1, and the hydrogen-rich oxygen-rich water is hydrogen-rich water and The oxygen-enriched water is a mixture having a mass ratio of 1:3, the hydrogen-rich water has a hydrogen concentration of 1.2 ppm, and the oxygen-enriched water has a dissolved oxygen concentration of 50 ppm.
- the specific activity of the superoxide dismutase used was 2000 IU/mg.
- trace element composition 1 part of trace element composition, 3 parts of collagen, 25 parts of hydrogen-rich oxygen-enriched water, 0.1 part of hyaluronic acid, 1 part of superoxide dismutase, wherein, trace element composition It is a combination of zinc gluconate and sodium selenite according to a mass ratio of 5:1.
- the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, and the hydrogen-rich water has a hydrogen concentration of 0.9.
- Ppm oxygen-enriched water contains a dissolved oxygen concentration of 20 ppm.
- the specific activity of the superoxide dismutase used was 1000 IU/mg.
- each component according to the following formula: 2 parts of trace element composition, 4 parts of collagen, 30 parts of hydrogen-rich oxygen-enriched water, 0.3 parts of hyaluronic acid, 3 parts of superoxide dismutase, among which, trace element composition It is a combination of zinc gluconate and sodium selenite according to a mass ratio of 7:1.
- the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water in a mass ratio of 1:2, and the hydrogen-rich water has a hydrogen concentration of l. .Oppm, oxygen-enriched water contains a dissolved oxygen concentration of 30 ppm.
- the specific activity of the superoxide dismutase used was 1500 IU/mg.
- each component was weighed according to the following formula: 1 part of trace element composition, 3 parts of collagen, 25 parts of hydrogen-rich oxygen-enriched water, 0.1 part of hyaluronic acid, 1 part of superoxide dismutase, and 5 parts of traditional Chinese medicine composition.
- the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 5:1
- the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water.
- the hydrogen concentration was 0.9 ppm
- the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm.
- the specific activity of the superoxide dismutase used was 1000 IU/mg.
- the traditional Chinese medicine composition used was prepared as follows:
- the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 5:1
- the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water.
- the hydrogen concentration was 0.9 ppm
- the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm.
- the specific activity of the superoxide dismutase used was 1000 IU/mg.
- the traditional Chinese medicine composition used was prepared as follows:
- the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 7:1
- the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water in a mass ratio of 1:2, hydrogen-rich water.
- the hydrogen concentration is 1.0 ppm
- the oxygen-enriched water contains a dissolved oxygen concentration of 30 ppm.
- the specific activity of the superoxide dismutase used was 1500 IU/mg.
- the traditional Chinese medicine composition used was prepared as follows:
- Trial results The users of Examples 1 ⁇ 3 have an effective rate of 90% after 3 weeks of continuous trial, the cure rate is 70 ⁇ 80%, the stain efficiency is 89%, and the stain cure rate is 65 ⁇ 78%;
- the users of Examples 4 to 6 had an effective rate of 96% after 2 weeks of continuous trial, a cure rate of 78 to 89%, and an effective rate of 95%.
- the cure rate is 80-90%.
- the face often has acne and the face is dull.
- the acne disappears and the skin is more moist and tender.
- White After using the product of the first embodiment of the invention for 3 weeks, the acne disappears and the skin is more moist and tender.
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Abstract
Provided in the present invention is a serum used for treatment of an acne hyperpigmentation spot and for whitening. The serum comprises constituents of the following parts by mass: 1 to 3 parts of a trace element composition, 3 to 5 parts of collagen, 25 to 35 parts of hydrogen-rich and oxygen-rich water, 0.1 to 0.5 parts of hyaluronic acid, and 1 to 5 parts of a superoxide dismutase, where the trace element composition is one or two between zinc gluconate and sodium selenite, and the hydrogen-rich and oxygen-rich water is a mixture of hydrogen-rich water and oxygen-rich water. The superoxide dismutase used by the present invention has a specific activity of 1000 to 2000 IU/mg. The serum provided in the present invention is of reduced irritativeness, is free of toxic side effects, allows for effective elimination of acne and fading of a hyperpigmentation spot, and at the same time provides a whitening effect.
Description
一种用于治疗青春痘色素沉斑和美白的精华液 技术领域 Essence for treating acne pigmentation and whitening
本发明涉及具有治疗青春痘、 淡化色素沉斑及具有美白作用的精华液。 The invention relates to an essence having the functions of treating acne, diminishing pigmentation spots and having whitening effect.
背景技术 Background technique
青春痘是一种皮肤病, 又称粉刺、 暗疮、 痤疮或面疮, 是处于青春期发育期、 油性 皮肤严重、 喜吃脂肪和糖类食品辛辣刺激食物因为熬夜或工作性质等因素造成的常见皮 肤病。 患者因皮脂腺分泌过盛, 大量的角质层脱落, 与油脂尘垢混合后, 使毛孔堵塞, 进而引发毛囊红肿发炎。严重时还会造成色素细胞增生, 留下难以消除的色素沉着斑等, 对患者容貌产生影响。 目前, 市场上治疗青春痘及青春痘造成的色素沉斑的化妆品大多 通过添加化学杀菌剂、 激素等来发挥作用, 虽然这些组分能够在短时间内杀菌或消除炎 症, 但对皮肤刺激性大, 长期使用会增加患者的皮肤负担, 甚至还会进一步引起皮肤红 肿、 化脓或疼痛, 有的还会激发色素细胞的进一步增生, 加重色素沉斑。 如何研制一种 更为安全、 温和、 有效的治疗青春痘及淡化色素沉斑的护肤品已成为本领域亟需取得突 破的课题之一。 Acne is a skin disease, also known as acne, acne, hemorrhoids or facial sores. It is a common skin that develops during puberty, oily skin, eats fat and sugary foods, stimulates food because of day or night or work nature. disease. The patient is over-secreted by sebaceous glands, and a large amount of stratum corneum is detached. When mixed with grease and dirt, the pores are blocked, which causes redness and inflammation of the hair follicle. In severe cases, it also causes pigment cell proliferation, leaving pigment spots that are difficult to eliminate, and affects the appearance of patients. At present, cosmetics for treating pigmentation caused by acne and acne are mostly used by adding chemical fungicides, hormones, etc., although these components can sterilize or eliminate inflammation in a short time, but are highly irritating to the skin. Long-term use will increase the patient's skin burden, and may even cause skin redness, suppuration or pain, and some will stimulate the further proliferation of pigment cells and aggravate pigmentation spots. How to develop a safer, gentler and more effective skin care product for treating acne and diminishing pigmentation spots has become one of the urgent problems in the field.
发明内容 Summary of the invention
为弥补现有技术的不足, 本发明的目的在于提供一种刺激性小、 无毒副作用、 可有 效祛除青春痘及淡化色素沉斑, 同时具有美白作用的外用精华液。 In order to make up for the deficiencies of the prior art, the object of the present invention is to provide a topical serum which has little irritation, has no toxic side effects, can effectively eliminate acne and dilute pigmentation spots, and has a whitening effect.
本发明解决其技术问题, 所采用的技术方案如下: The invention solves the technical problems thereof, and the technical solutions adopted are as follows:
一种用于治疗青春痘色素沉斑和美白的精华液, 其特征在于, 精华液包含如下质量 份的各组份: 微量元素组合物 1~3份、 胶原蛋白 3~5份、 富氢富氧水 25~35份、 玻尿酸 0.1~0.5份、 超氧化物歧化酶 1~5份, 其中, 所述微量元素组合物为葡萄糖酸锌、 亚硒酸 钠中的一种或两种, 富氢富氧水为富氢水和富氧水的混合物。 本发明所用的超氧化物歧 化酶其比活力为 1000~2000IU/mg。 An essence for treating acne pigmentation and whitening, characterized in that the essence contains the following components by mass: 1 to 3 parts of the trace element composition, 3 to 5 parts of the collagen, and rich in hydrogen 25 to 35 parts of oxygen water, 0.1 to 0.5 parts of hyaluronic acid, and 1 to 5 parts of superoxide dismutase, wherein the trace element composition is one or two of zinc gluconate and sodium selenite, and is rich in hydrogen. The oxygen-enriched water is a mixture of hydrogen-rich water and oxygen-enriched water. The superoxide dismutase used in the present invention has a specific activity of 1000 to 2000 IU/mg.
所述微量元素组合物为葡萄糖酸锌和亚硒酸钠按照质量比 (5~10): 1组合而成。 所述富氢富氧水为质量比 1: ( 1-3 ) 的富氢水和富氧水的组合。 The trace element composition is a combination of zinc gluconate and sodium selenite according to a mass ratio (5-10):1. The hydrogen-rich oxygen-enriched water is a combination of hydrogen-rich water and oxygen-enriched water having a mass ratio of 1: (1-3).
所述富氢水其含氢 (以氢气分子计) 浓度为 0.9~1.2ppm, 所述富氧水其含有的溶解 氧浓度为 20~50ppm。 The hydrogen-rich water has a hydrogen (in terms of hydrogen molecules) concentration of 0.9 to 1.2 ppm, and the oxygen-enriched water contains a dissolved oxygen concentration of 20 to 50 ppm.
优选的, 所述精华液还包含 5~10质量份中药组合物, 所述中药组合物由如下药材配 方的各组分提取制得: 木槿花 1~5质量份、 草石蚕 2~5质量份、 牡丹根皮 1~3质量份、
甘草 2~6质量份、 白茯苓 1~4质量份。 Preferably, the essence further comprises 5 to 10 parts by mass of a traditional Chinese medicine composition, and the traditional Chinese medicine composition is obtained by extracting the components of the following medicinal material formula: 1 to 5 parts by mass of hibiscus, 2 to 5 masses of sarcophagus Parts, peony root skin 1~3 parts by mass, 2 to 6 parts by mass of licorice and 1 to 4 parts by mass of white peony.
进一步优选的, 所述药材配方为: 木槿花 3质量份、 草石蚕 4质量份、 牡丹根皮 2 质量份、 甘草 4质量份、 白茯苓 2质量份。 Further preferably, the medicinal material is formulated as: 3 parts by mass of hibiscus, 4 parts by mass of sarcophagus, 2 parts by mass of peony root, 4 parts by mass of licorice, and 2 parts by mass of peony.
优选的, 所述中药组合物按照如下步骤的提取工艺制得: Preferably, the traditional Chinese medicine composition is prepared according to the following extraction process:
1 )按药材配方称取各味药材, 将草石蚕、 牡丹根皮、 白茯苓粉碎后与木槿花、 甘草 混合, 加入去离子水室温浸泡 4~8小时, 所加水量为药材总质量的 4~6倍; 1) Weigh each medicinal material according to the medicinal material formula, crush the grass stone silkworm, peony root bark and white peony, mix it with hibiscus and licorice, add deionized water for 4~8 hours at room temperature, and add water to the total quality of the medicinal material. 4~6 times;
2) 之后在 50~60°C下加热煎煮 3~5小时, 将所得提取液进行过滤, 所得滤液即为中 药组合物。 2) After heating and boiling at 50 to 60 ° C for 3 to 5 hours, the obtained extract is filtered, and the obtained filtrate is a traditional Chinese medicine composition.
下面对本发明的技术方案中所用的几种组分进行介绍: The following describes the components used in the technical solution of the present invention:
胶原蛋白: 胶原蛋白 (collagen) 是一种生物性高分子物质, 是一种白色、 不透明、 无支链的纤维性蛋白质。 它可以补充皮肤各层所需的营养, 使皮肤中胶原活性增强, 对 滋润皮肤, 延缓衰老、 美容、 消皱、 养发等有一定功效。 Collagen: Collagen (collagen) is a biological polymer substance, a white, opaque, unbranched fibrous protein. It can replenish the nutrients needed in all layers of the skin, enhance the collagen activity in the skin, and have certain effects on moisturizing the skin, delaying aging, beauty, wrinkle and hair growth.
富氢水: 又称水素水 (Hydrogen Water), 是日语的音译, 氢气本身就是一种最佳天 然抗氧化剂, 所以加入氢气的水具有很强的还原功能。 可以中和身体血液和细胞里的活 性氧(自由基)。 现代医学认为活性氢可以有效去除体内自由基, 富氢水具有超过维生素 C、胡萝卜、卵磷脂等所有人类已知抗氧化物的抗氧化性,对过敏性皮炎、便秘、高血压、 糖尿病、 癌症等由自由基引起的各类症状都有强大的防治作用。 富氢水能够很好的促进 新陈代谢, 使每个细胞都能自动保持健康的状态, 去除体锈, 延缓衰老。 富氢水其制取 方法已是一种较为成熟的技术, 如公开号为 CN102408147A的中国专利申请介绍了富氢 水的一种制取方法。 Hydrogen-rich water: Also known as Hydrogen Water, it is a transliteration of Japanese. Hydrogen itself is one of the best natural antioxidants, so the water added with hydrogen has a strong reducing function. It can neutralize active oxygen (free radicals) in the body's blood and cells. Modern medicine believes that active hydrogen can effectively remove free radicals in the body. Hydrogen-rich water has more antioxidant properties than all known human antioxidants such as vitamin C, carrots, lecithin, etc., for allergic dermatitis, constipation, hypertension, diabetes, cancer. All kinds of symptoms caused by free radicals have a strong preventive effect. Hydrogen-rich water promotes metabolism and allows each cell to maintain a healthy state, remove body rust and delay aging. The preparation method of hydrogen-rich water has been a relatively mature technology, and a method for preparing hydrogen-rich water is described in Chinese Patent Application Publication No. CN102408147A.
富氧水: 是指使溶于水中的溶解氧浓度而比一般的水高的含有更多氧的水。 将这种 含有高浓度溶解氧的水直接供给到皮肤上, 能够促进皮肤细胞的呼吸病活化细胞, 提高 保湿能力, 延缓衰老, 促进皮肤的更新, 从而促进排出皮肤中生产的黑色素, 从而可以 显示美白效果。 富氧水是一种天然的抗微生物防腐剂与氧增加剂, 可促进皮肤的新陈代 谢, 促进整体皮肤的健康。 富氧水其制取方法已是一种成熟的技术, 如公开号为 CN1200355A的中国专利申请以及公开号为 CN102641223A的中国专利申请中均介绍了 富氧水的制取方法。 Oxygen-enriched water: refers to water containing more oxygen in which the dissolved oxygen concentration in water is higher than that of ordinary water. By directly supplying the water containing a high concentration of dissolved oxygen to the skin, it can promote the respiratory cells of the skin cells to activate the cells, improve the moisturizing ability, delay the aging, promote the renewal of the skin, and thereby promote the discharge of melanin produced in the skin, thereby displaying Whitening effect. Oxygen-enriched water is a natural anti-microbial preservative and oxygen booster that promotes skin metabolism and promotes overall skin health. The preparation method of the oxygen-enriched water is a well-established technique, and the preparation method of the oxygen-enriched water is described in the Chinese Patent Application Publication No. CN1200355A and the Chinese Patent Application Publication No. WO102641223A.
玻尿酸: 玻尿酸不仅有保持皮肤弹性的功能, 还能锁住大量水分子, 对组织具有保 湿润滑作用, 使肌肤饱满年轻有弹性, 但随着年龄的增长, 玻尿酸流失的速度比生长速 度快时, 肌肤也将渐渐变得缺乏水分, 失去光泽弹性, 长久下来便出现皱纹等老化现象。
超氧化物歧化酶(SOD): SOD 是很强的氧化还原剂, 能与体内的氧自由基发生还 原反应, 从而使人体细胞修复和基因组织不受损害; 对人体不断地补充 SOD具有抗衰老 的效果, 超氧化物歧化酶 (SOD) 为自由基清除剂, 能清除自由基 02- (超氧阴离子自 由基), 而 02-具有细胞毒性, 可使脂质过氧化, 损伤细胞膜, 引起炎症, 肿瘤和自身免 疫性疾病, 并可能促使机体衰老。 SOD是强力自由基清除剂, 可以抑制色素细胞沉积, 具有抗衰老、 免疫调节和抗辐射作用。 Hyaluronic acid: Hyaluronic acid not only has the function of maintaining skin elasticity, but also locks a lot of water molecules, which has moisturizing and lubricating effect on tissues, making the skin full and young and elastic, but as the age increases, the rate of hyaluronic acid loss is faster than the growth rate. The skin will gradually become dehydrated, lose its luster and elasticity, and wrinkles and other aging phenomena will appear over time. Superoxide dismutase (SOD): SOD is a strong redox agent that can react with oxygen free radicals in the body, so that human cell repair and gene organization are not damaged. Anti-aging is constantly supplemented by SOD. The effect of superoxide dismutase (SOD) is a free radical scavenger that scavenges free radicals 02- (superoxide anion radicals), while 02- is cytotoxic, can cause lipid peroxidation, damage cell membranes, cause inflammation , tumors and autoimmune diseases, and may cause the body to age. SOD is a powerful free radical scavenger that inhibits pigment cell deposition and has anti-aging, immune regulation and anti-radiation effects.
木槿花: 含有丰富的维生素 C、 铁、 钙、 锌、 硒等微量元素, 并含有黄酮类活性化 合物及粘液质。 木槿花提取液具有保湿、 抗氧化、 清除自由基的功能, 能抑制金黄色葡 萄球菌和伤寒杆菌。 Hibiscus: It is rich in vitamin C, iron, calcium, zinc, selenium and other trace elements, and contains flavonoid active compounds and mucus. The hibiscus extract has the functions of moisturizing, anti-oxidation and scavenging free radicals, and can inhibit Staphylococcus aureus and Salmonella typhi.
草石蚕: 又名银条, 是我国河南省偃师市的特产, 形状、 味道与绿豆芽相似。 草石 蚕富含糖类、 酚类、 维生素 c、 粗蛋白、 氨基酸、 有机酸等物质, 对软化血管、 降低血 月旨、 改善血液循环具有独特的疗效。 Grass stone silkworm: Also known as silver bar, it is a specialty of Yanshi City, Henan Province, China. Its shape and taste are similar to those of green bean sprouts. Grass stone Silkworm is rich in sugar, phenols, vitamin c, crude protein, amino acids, organic acids, etc. It has a unique effect on softening blood vessels, lowering blood and improving blood circulation.
牡丹根皮: 为毛茛科植物牡丹干燥根皮。 所含牡丹酚及其以外的糖苷类成分均有抗 炎作用; 牡丹皮的甲醇提取物有抑制血小板作用; 牡丹酚有镇静、 降温、 解热、 镇痛、 解痉等中枢抑制作用及抗动脉粥样硬化、 利尿、 抗溃疡等作用。 牡丹根皮提取成分有抗 菌消炎除痘和美白等作用。 Peony root bark: dry root bark of peony family of Ranunculaceae. The peony phenol and other glycoside components have anti-inflammatory effects; the methanol extract of peony bark has the effect of inhibiting platelets; peony phenol has central inhibition of sedation, cooling, antipyretic, analgesic, antispasmodic and anti-arterial Atherosclerosis, diuretic, anti-ulcer and so on. The extract of peony root bark has anti-bacterial, anti-inflammatory, acne and whitening effects.
甘草: 味甘、 平。 甘草还有抗炎, 抗过敏作用, 能保护发炎的咽喉和气管粘膜。 甘 草浸膏和甘草酸对某些毒物有类似葡萄糖醛酸的解毒作用。甘草能清热解毒, 润肺止咳, 调和诸药性; 具有抗炎、 抗病毒, 和保肝解毒及增强免疫功能等作用。 缓解药物毒性、 烈性。 甘草的黄酮具有消炎、 解痉和抗酸作用; 解毒作用的有效成份为甘草甜素, 解毒 机制为甘草甜素对毒物有吸附作用。 Licorice: Sweet and flat. Licorice also has anti-inflammatory and anti-allergic effects, which can protect the inflamed throat and tracheal mucosa. Licorice extract and glycyrrhizic acid have a detoxifying effect similar to glucuronic acid to certain poisons. Licorice can clear away heat and detoxify, moisten the lungs and relieve cough, and reconcile various medicinal properties; it has anti-inflammatory, anti-viral, liver-protecting and detoxifying functions and enhances immune function. Relieve the toxicity and potency of the drug. The flavonoids of licorice have anti-inflammatory, antispasmodic and anti-acid effects; the effective component of detoxification is glycyrrhizin, and the detoxification mechanism is the adsorption of glycyrrhizin on poisons.
白茯苓: 具有美白抗炎, 防护紫外线损伤, 促进皮肤代谢的作用。 White peony: It has whitening and anti-inflammatory properties, protects against UV damage and promotes skin metabolism.
本发明所采用的技术方案具有如下有益效果: The technical solution adopted by the invention has the following beneficial effects:
( 1 )本发明一种实施方案中, 在精华液中添加微量元素组合物、 胶原蛋白、 富氢富 氧水、 玻尿酸、 超氧化物歧化酶, 这些组分按照特定的质量配伍, 对青春痘具有良好的 治疗效果, 对沉着色斑具有淡化功效, 同时起到美白作用。 由葡萄糖酸锌、 亚硒酸钠组 合形成的微量元素组合物, 可为皮肤补充锌、 硒。 锌具有协调免疫反应的作用, 锌参与 碳酸酐酶、 碱性磷酸酶、 DNA聚合酶等多种酶的合成, 增加创伤组织的修复。 硒是功效 卓著和全面的抗氧化剂, 在大幅延迟细胞衰老的同时还同步有力阻止胶原蛋白变性, 亦 即增加胶原蛋白合成量又减少其流失量。 目前的研究证明, 硒具有抗氧化作用, 清除自
由基保护细胞膜结构合功能, 修复分子损伤部位; 硒可促进体内多种代谢活动, 硒是肌 肉的正常成分, 是谷胱甘肽过氧化酶的必需成分呢, 硒在人体内有拮抗和降低多种重金 属毒性的作用, 硒能刺激免疫球蛋白和抗体的产生, 提高肌体免疫功能。 富氢水和富氧 水混合形成的富氢富氧水, 含有丰富的活性氢和溶解氧, 促进新陈代谢, 使每个细胞都 能自动保持健康的状态, 有效清除体内自由基, 促进皮肤细胞的呼吸并活化细胞, 提高 保湿能力, 促进皮肤的更新及排出皮肤中产生的黑色素。 配方中同时搭配胶原蛋白、 玻 尿酸及超氧化物歧化酶, 为肌肤补充水分营养及胶原蛋白成分, 同时 SOD作为强力自由 基清除剂, 还可抑制色素细胞沉积。 在这种方案, 微量元素、 胶原蛋白、 富氢富氧水、 玻尿酸和超氧化物歧化酶合理搭配应用, 能提高机体免疫力、 修复创伤、 活化细胞, 达 到祛痘的目的, 同时还可促进细胞新陈代谢及抑制黑色素沉积, 实现淡化色素沉斑的效 果。 实践证明, 连续使用 3周后青春痘有效率就可达到 90%, 治愈率可达到 70~80%, 色斑有效率可达到 89%, 色斑治愈率可达到 65~78%; (1) In one embodiment of the present invention, a trace element composition, collagen, hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase is added to the essence, and these components are compatible with a specific quality, and are suitable for acne It has a good therapeutic effect, has a lightening effect on the sun stains, and at the same time plays a whitening effect. A trace element composition formed by a combination of zinc gluconate and sodium selenite, which can supplement zinc and selenium to the skin. Zinc has a role in coordinating immune responses. Zinc is involved in the synthesis of various enzymes such as carbonic anhydrase, alkaline phosphatase, and DNA polymerase, and increases the repair of wound tissue. Selenium is an effective and comprehensive antioxidant that dramatically delays cell aging while simultaneously preventing collagen denaturation, which increases collagen synthesis and reduces its loss. Current research shows that selenium has an antioxidant effect, Protects the molecular damage site by protecting the cell membrane structure; Selenium can promote various metabolic activities in the body. Selenium is a normal component of muscle and an essential component of glutathione peroxidase. Selenium is antagonistic and reduced in the human body. A variety of heavy metal toxicity, selenium can stimulate the production of immunoglobulins and antibodies, improve the body's immune function. The hydrogen-rich and oxygen-rich water formed by the mixture of hydrogen-rich water and oxygen-enriched water is rich in active hydrogen and dissolved oxygen, promotes metabolism, enables each cell to maintain a healthy state automatically, effectively removes free radicals in the body, and promotes skin cells. Breathe and activate cells, improve moisturizing ability, promote skin renewal and discharge melanin produced in the skin. Formulated with collagen, hyaluronic acid and superoxide dismutase to replenish moisture and collagen to the skin. SOD acts as a powerful free radical scavenger and inhibits pigment cell deposition. In this scheme, the combination of trace elements, collagen, hydrogen-rich oxygen-enriched water, hyaluronic acid and superoxide dismutase can improve the body's immunity, repair wounds, activate cells, achieve acne, and promote Cell metabolism and inhibition of melanin deposition, to achieve the effect of lightening pigmentation spots. Practice has proved that after 3 weeks of continuous use, the efficiency of acne can reach 90%, the cure rate can reach 70-80%, the effective rate of stain can reach 89%, and the cure rate of stain can reach 65~78%;
(2) 本发明的一种优选方案中, 在精华液中进一步添加中药组合物, 其由木槿花、 草石蚕、 牡丹根皮、 甘草、 白茯苓这几种中药材按照一定质量配伍形成, 可为精华液补 充天然有效成分, 提升祛痘及淡化沉斑的效果。 木槿花中含有多种微量元素, 使精华液 中具有不同来源的更为丰富的微量元素, 这些不同来源的微量元素协同作用, 加速对损 伤细胞的修复, 更好的提升机体免疫力、 抵抗外部环境侵扰。 通过在精华液中添加由木 槿花、 草石蚕、 牡丹根皮、 甘草、 白茯苓混合提取制得的中药组合物, 还进一步为精华 液补充了植物来源的维生素 C、 黄酮类活性化合物、 粘液质、 酚类、 粗蛋白、 氨基酸、 有机酸、 牡丹酚、 甘草酸等丰富的活性物质, 不仅可进一步提升抗氧化作用、 抑菌抗菌 作用, 而且还可补充肌肤营养、 活化肌肤、 美白淡化肌肤色斑。 采用这种优选方案, 可 以縮短显效时间。 实践证明, 该优选方案制备的精华液, 使用者连续使用 2周后, 就可 有效治疗青春痘、 淡化色斑, 青春痘有效率可达到 96%, 治愈率可达到 78~89%, 色斑 有效率可达到 95%, 色斑治愈率可达到 80~90%。 (2) In a preferred embodiment of the present invention, a traditional Chinese medicine composition is further added to the essence, which is formed by combining a certain amount of Chinese medicinal materials such as hibiscus, grass stone, peony root, licorice and white peony according to a certain quality. It can replenish the essence with natural active ingredients to enhance the effect of acne and fade spots. Hibiscus contains a variety of trace elements, which make the extracts richer trace elements from different sources. These trace elements from different sources work synergistically to accelerate the repair of damaged cells, improve the body immunity and resist external Environmental intrusion. By adding a traditional Chinese medicine composition obtained by extracting hibiscus, grass stone silkworm, peony root bark, licorice, and white peony to the essence, the extract is further supplemented with plant-derived vitamin C, flavonoid active compound, mucilage. Rich in active substances such as phenols, crude protein, amino acids, organic acids, peony phenol, glycyrrhizic acid, etc., not only can further enhance anti-oxidation, antibacterial and antibacterial effects, but also replenish skin nutrition, activate skin, whiten and fade skin Spot. With this preferred solution, the time to effect can be shortened. Practice has proved that the essence prepared by the preferred solution can effectively treat acne and dilute pigmentation after 2 weeks of continuous use, and the acne can reach 96%, and the cure rate can reach 78-89%. The effective rate can reach 95%, and the stain cure rate can reach 80~90%.
( 3 ) 本发明提供的精华液安全性好, 无毒副作用。 (3) The essence provided by the invention has good safety and no toxic and side effects.
具体实施方式 detailed description
下面结合实施例对本发明作进一步详细说明。 The present invention will be further described in detail below with reference to the embodiments.
实施例 1 : Example 1
一种用于治疗青春痘色素沉斑和美白的精华液 An essence for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 3份、 胶原蛋白 5份、 富氢富氧水
35份、 玻尿酸 0.5份、 超氧化物歧化酶 5份, 其中, 微量元素组合物为葡萄糖酸锌、 亚 硒酸钠按照质量比 10: 1组合而成, 富氢富氧水为富氢水和富氧水按照质量比 1: 3的混 合物, 富氢水其含氢浓度为 1.2ppm, 富氧水其溶解氧浓度为 50ppm。 所用超氧化物歧化 酶的比活力为 2000IU/mg。 (1) Weigh each component according to the following formula: 3 parts of trace element composition, 5 parts of collagen, hydrogen-rich oxygen-enriched water 35 parts, 0.5 parts of hyaluronic acid and 5 parts of superoxide dismutase, wherein the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 10:1, and the hydrogen-rich oxygen-rich water is hydrogen-rich water and The oxygen-enriched water is a mixture having a mass ratio of 1:3, the hydrogen-rich water has a hydrogen concentration of 1.2 ppm, and the oxygen-enriched water has a dissolved oxygen concentration of 50 ppm. The specific activity of the superoxide dismutase used was 2000 IU/mg.
(2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用; (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
( 3 )将富氢富氧水、 玻尿酸、 超氧化物歧化酶倒入另一已消毒的容器中, 搅拌至各 组份完全溶解并混匀, 将步骤 2中的物质倒入其中, 并不断搅拌至完全呈透明溶液, 最 后进行灭菌灌装。 (3) Pour hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase into another sterilized container, stir until the components are completely dissolved and mixed, pour the substance in step 2 into it, and continue Stir until completely clear solution, and finally sterilize the filling.
实施例 2: Example 2:
一种用于治疗青春痘色素沉斑和美白的精华液 An essence for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 1份、 胶原蛋白 3份、 富氢富氧水 25份、 玻尿酸 0.1份、 超氧化物歧化酶 1份, 其中, 微量元素组合物为葡萄糖酸锌、 亚 硒酸钠按照质量比 5: 1组合而成, 富氢富氧水为富氢水和富氧水按照质量比 1:1的混合 物, 富氢水其含氢浓度为 0.9ppm, 富氧水其含有的溶解氧浓度为 20ppm。 所用超氧化物 歧化酶的比活力为 1000IU/mg。 (1) Weigh each component according to the following formula: 1 part of trace element composition, 3 parts of collagen, 25 parts of hydrogen-rich oxygen-enriched water, 0.1 part of hyaluronic acid, 1 part of superoxide dismutase, wherein, trace element composition It is a combination of zinc gluconate and sodium selenite according to a mass ratio of 5:1. The hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, and the hydrogen-rich water has a hydrogen concentration of 0.9. Ppm, oxygen-enriched water contains a dissolved oxygen concentration of 20 ppm. The specific activity of the superoxide dismutase used was 1000 IU/mg.
(2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用; (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
( 3 )将富氢富氧水、 玻尿酸、 超氧化物歧化酶倒入另一已消毒的容器中, 搅拌至各 组份完全溶解并混匀, 将步骤 2中的物质倒入其中, 并不断搅拌至完全呈透明溶液, 最 后进行灭菌灌装。 (3) Pour hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase into another sterilized container, stir until the components are completely dissolved and mixed, pour the substance in step 2 into it, and continue Stir until completely clear solution, and finally sterilize the filling.
实施例 3: Example 3:
一种用于治疗青春痘色素沉斑和美白的精华液 An essence for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 2份、 胶原蛋白 4份、 富氢富氧水 30份、 玻尿酸 0.3份、 超氧化物歧化酶 3份, 其中, 微量元素组合物为葡萄糖酸锌、 亚 硒酸钠按照质量比 7: 1组合而成, 富氢富氧水为富氢水和富氧水按照质量比 1:2的混合 物, 富氢水其含氢浓度为 l.Oppm, 富氧水其含有的溶解氧浓度为 30 ppm。所用超氧化物 歧化酶的比活力为 1500IU/mg。 (1) Weigh each component according to the following formula: 2 parts of trace element composition, 4 parts of collagen, 30 parts of hydrogen-rich oxygen-enriched water, 0.3 parts of hyaluronic acid, 3 parts of superoxide dismutase, among which, trace element composition It is a combination of zinc gluconate and sodium selenite according to a mass ratio of 7:1. The hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water in a mass ratio of 1:2, and the hydrogen-rich water has a hydrogen concentration of l. .Oppm, oxygen-enriched water contains a dissolved oxygen concentration of 30 ppm. The specific activity of the superoxide dismutase used was 1500 IU/mg.
(2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用; (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
( 3 )将富氢富氧水、 玻尿酸、 超氧化物歧化酶倒入另一已消毒的容器中, 搅拌至各 组份完全溶解并混匀, 将步骤 2中的物质倒入其中, 并不断搅拌至完全呈透明溶液, 最 后进行灭菌灌装。
实施例 4: (3) Pour hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase into another sterilized container, stir until the components are completely dissolved and mixed, pour the substance in step 2 into it, and continue Stir until completely clear solution, and finally sterilize the filling. Example 4:
一种用于治疗青春痘色素沉斑和美白的精华液 An essence for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 1份、 胶原蛋白 3份、 富氢富氧水 25份、 玻尿酸 0.1份、 超氧化物歧化酶 1份, 中药组合物 5份。 其中, 微量元素组合物 为葡萄糖酸锌、 亚硒酸钠按照质量比 5: 1组合而成, 富氢富氧水为富氢水和富氧水按照 质量比 1:1的混合物,富氢水其含氢浓度为 0.9ppm,富氧水其含有的溶解氧浓度为 20ppm。 所用超氧化物歧化酶的比活力为 1000IU/mg。 (1) Each component was weighed according to the following formula: 1 part of trace element composition, 3 parts of collagen, 25 parts of hydrogen-rich oxygen-enriched water, 0.1 part of hyaluronic acid, 1 part of superoxide dismutase, and 5 parts of traditional Chinese medicine composition. Wherein, the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 5:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water. The hydrogen concentration was 0.9 ppm, and the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm. The specific activity of the superoxide dismutase used was 1000 IU/mg.
(2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用; (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
( 3 )将富氢富氧水、 玻尿酸、 超氧化物歧化酶、 中药组合物倒入另一已消毒的容器 中, 搅拌至各组份完全溶解并混匀, 将步骤 2中的物质倒入其中, 并不断搅拌混匀各组 份, 使各组份均完全溶解, 最后进行灭菌灌装。 (3) Pour hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase, and traditional Chinese medicine composition into another sterilized container, stir until the components are completely dissolved and mixed, and pour the substance in step 2 into Among them, the components are continuously stirred and mixed, so that the components are completely dissolved, and finally, the sterilization is filled.
所用的中药组合物按照如下步骤制备: The traditional Chinese medicine composition used was prepared as follows:
a: 按照如下药材配方称取各组分: 木槿花 1质量份、 草石蚕 2质量份、 牡丹根皮 1 质量份、 甘草 2质量份、 白茯苓 1质量份; a: Weigh each component according to the following medicinal formula: 1 part by mass of hibiscus, 2 parts by mass of sarcophagus, 1 part by mass of peony root, 2 parts by weight of licorice, and 1 part by mass of peony;
b: 将草石蚕、 牡丹根、 白茯苓粉碎后与木槿花、 甘草混合, 加入去离子水室温浸泡 b: After crushing the grass stone, peony root and white peony, mix it with hibiscus and licorice, add deionized water to soak at room temperature.
4小时, 所加水量为药材总质量的 4倍; 4 hours, the amount of water added is 4 times the total mass of the medicine;
c: 之后在 50~60°C下加热煎煮 3小时, 将所得提取液进行过滤。 c: After heating and boiling at 50 to 60 ° C for 3 hours, the resulting extract was filtered.
实施例 5 : Example 5:
一种用于治疗青春痘色素沉斑和美白的精华液 An essence for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 1份、 胶原蛋白 3份、 富氢富氧水 (1) Weigh each component according to the following formula: Trace element composition 1 part, collagen 3 parts, hydrogen-rich oxygen-enriched water
25份、 玻尿酸 0.1份、 超氧化物歧化酶 1份、 中药组合物 8份。 其中, 微量元素组合物 为葡萄糖酸锌、 亚硒酸钠按照质量比 5: 1组合而成, 富氢富氧水为富氢水和富氧水按照 质量比 1:1的混合物,富氢水其含氢浓度为 0.9ppm,富氧水其含有的溶解氧浓度为 20ppm。 所用超氧化物歧化酶的比活力为 1000IU/mg。 25 parts, 0.1 parts of hyaluronic acid, 1 part of superoxide dismutase, and 8 parts of traditional Chinese medicine composition. Wherein, the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 5:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water. The hydrogen concentration was 0.9 ppm, and the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm. The specific activity of the superoxide dismutase used was 1000 IU/mg.
(2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用; (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
( 3 )将富氢富氧水、 玻尿酸、 超氧化物歧化酶、 中药组合物倒入另一已消毒的容器 中, 搅拌至各组份完全溶解并混匀, 将步骤 2中的物质倒入其中, 并不断搅拌至完全呈 透明溶液, 最后进行灭菌灌装。 (3) Pour hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase, and traditional Chinese medicine composition into another sterilized container, stir until the components are completely dissolved and mixed, and pour the substance in step 2 into Among them, and constantly stirring until completely transparent solution, and finally sterilized filling.
所用的中药组合物按照如下步骤制备: The traditional Chinese medicine composition used was prepared as follows:
a: 按照如下药材配方称取各组分: 木槿花 5质量份、 草石蚕 5质量份、 牡丹根皮 3
质量份、 甘草 6质量份、 白茯苓 4质量份; a: Weigh each component according to the following herbal formula: 5 parts by weight of hibiscus, 5 parts by weight of grass stone, and peony root 3 Parts by mass, 6 parts by mass of licorice, 4 parts by mass of white peony;
b: 将草石蚕、 牡丹根、 白茯苓粉碎后与木槿花、 甘草混合, 加入去离子水室温浸泡 8小时, 所加水量为药材总质量的 6倍; b: crushing grass stone, peony root and white peony, mixing with hibiscus and licorice, adding deionized water for 8 hours at room temperature, the added water is 6 times of the total mass of the medicinal material;
c: 之后在 50~60°C下加热煎煮 5小时, 将所得提取液进行过滤。 c: After heating and boiling at 50 to 60 ° C for 5 hours, the resulting extract was filtered.
实施例 6: Example 6:
一种用于治疗青春痘色素沉斑和美白的精华液 An essence for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 2份、 胶原蛋白 4份、 富氢富氧水 30份、 玻尿酸 0.3份、 超氧化物歧化酶 3份、 中药组合物 10份, 其中, 微量元素组合物 为葡萄糖酸锌、 亚硒酸钠按照质量比 7: 1组合而成, 富氢富氧水为富氢水和富氧水按照 质量比 1:2 的混合物, 富氢水其含氢浓度为 l.Oppm, 富氧水其含有的溶解氧浓度为 30 ppm。 所用超氧化物歧化酶的比活力为 1500IU/mg。 (1) Weigh each component according to the following formula: 2 parts of trace element composition, 4 parts of collagen, 30 parts of hydrogen-rich oxygen-enriched water, 0.3 parts of hyaluronic acid, 3 parts of superoxide dismutase, 10 parts of traditional Chinese medicine composition, Wherein, the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 7:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water in a mass ratio of 1:2, hydrogen-rich water. The hydrogen concentration is 1.0 ppm, and the oxygen-enriched water contains a dissolved oxygen concentration of 30 ppm. The specific activity of the superoxide dismutase used was 1500 IU/mg.
(2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用; (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
( 3 )将富氢富氧水、 玻尿酸、 超氧化物歧化酶、 中药组合物倒入另一已消毒的容器 中, 搅拌至各组份完全溶解并混匀, 将步骤 2中的物质倒入其中, 并不断搅拌至完全呈 透明溶液, 最后进行灭菌灌装。 (3) Pour hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase, and traditional Chinese medicine composition into another sterilized container, stir until the components are completely dissolved and mixed, and pour the substance in step 2 into Among them, and constantly stirring until completely transparent solution, and finally sterilized filling.
所用的中药组合物按照如下步骤制备: The traditional Chinese medicine composition used was prepared as follows:
a: 按照如下药材配方称取各组分: 木槿花 3质量份、 草石蚕 4质量份、 牡丹根皮 2 质量份、 甘草 4质量份、 白茯苓 2质量份; a: Weigh each component according to the following medicinal formula: 3 parts by mass of hibiscus, 4 parts by mass of phytolith, 2 parts by mass of peony root, 4 parts by weight of licorice, and 2 parts by weight of peony;
b: 将草石蚕、 牡丹根、 白茯苓粉碎后与木槿花、 甘草混合, 加入去离子水室温浸泡 6小时, 所加水量为药材总质量的 5倍; b: The grass stone silkworm, the peony root and the white peony are crushed, mixed with hibiscus and licorice, and added with deionized water for 6 hours at room temperature, and the added water is 5 times of the total mass of the medicinal material;
c: 之后在 50~60°C下加热煎煮 4小时, 将所得提取液进行过滤。 c: After heating and boiling at 50 to 60 ° C for 4 hours, the resulting extract was filtered.
效果测试: Performance test:
每个实施例均选择 50人进行试用,试用者的入选标准为患有青春痘或因曾经患有青 春痘而造成面部有色素沉斑。 For each of the examples, 50 people were selected for trial. The tester's inclusion criteria were that they had acne or had pigmentation spots on the face due to the previous occurrence of blue acne.
使用方法: 在患处涂抹精华液, 每日早晚各 1次。 How to use: Apply the essence to the affected area, once a day in the morning and evening.
疗效评定标准: 使用者用后青春痘减少、 炎症减轻、 红色变浅为有效; 青春痘完全 消失为痊愈; 色斑变浅变少为有效; 色斑完全消失为痊愈。 Efficacy evaluation criteria: After the user reduced acne, inflammation decreased, red lightened to be effective; acne completely disappeared to cure; the pigmentation became less effective and less effective; the stain disappeared completely to cure.
试用结果: 实施例 1~3的使用者连续试用 3周后青春痘有效率达到 90%, 治愈率达 到 70~80%, 色斑有效率达到 89%, 色斑治愈率达到 65~78%; 实施例 4~6的使用者连续 试用 2周后青春痘有效率达到 96%, 治愈率达到 78~89%, 色斑有效率达到 95%, 色斑
治愈率达到 80~90%。 Trial results: The users of Examples 1~3 have an effective rate of 90% after 3 weeks of continuous trial, the cure rate is 70~80%, the stain efficiency is 89%, and the stain cure rate is 65~78%; The users of Examples 4 to 6 had an effective rate of 96% after 2 weeks of continuous trial, a cure rate of 78 to 89%, and an effective rate of 95%. The cure rate is 80-90%.
典型例子介绍: A typical example is introduced:
万某, 25岁, 网络工程师, 工作需长期面对电脑, 脸上经常长痘痘, 面部暗沉, 使 用本发明实施例 1的产品 3周后, 痘痘消失了, 皮肤也更加水润嫩白。 Wanmou, 25 years old, network engineer, needs to face the computer for a long time. The face often has acne and the face is dull. After using the product of the first embodiment of the invention for 3 weeks, the acne disappears and the skin is more moist and tender. White.
刘某, 17岁, 学生, 由于升学压力大, 作息时间不规律, 脸上长满了青春痘, 脸上 还几处色斑, 使用本发明实施例 5的产品 2周后, 大部分痘痘都消失了, 色斑得到明显 淡化, 皮肤显得白皙。 以上所述, 仅是本发明的较佳实施例而已, 并非对本发明做任何形式上的限制, 故 凡未脱离本发明技术方案的内容, 依据本发明的技术实质对以上实施例所做的任何简单 修改、 等同变化与修饰, 均仍属于本发明技术方案的范围内。
Liu, 17 years old, student, due to the pressure of further study, irregular schedule, face full of acne, several spots on his face, after using the product of Example 5 of the present invention for 2 weeks, most of the acne All disappeared, the stains were noticeably faded, and the skin appeared white. The above is only the preferred embodiment of the present invention, and is not intended to limit the present invention in any way. Therefore, any of the above embodiments can be made according to the technical essence of the present invention without departing from the technical solution of the present invention. Simple modifications, equivalent changes and modifications are still within the scope of the technical solutions of the present invention.
Claims
1、 一种用于治疗青春痘色素沉斑和美白的精华液, 其特征在于, 精华液包含如下质量份 的各组份: 微量元素组合物 1~3份、 胶原蛋白 3~5份、 富氢富氧水 25~35份、 玻尿酸 0.1~0.5份、 超氧化物歧化酶 1~5份, 其中, 所述微量元素组合物为葡萄糖酸锌、 亚 硒酸钠中的一种或两种, 富氢富氧水为富氢水和富氧水的混合物。 1. An essence for treating acne, pigmentation, spots and whitening. It is characterized in that the essence contains the following components by mass: 1 to 3 parts of trace element composition, 3 to 5 parts of collagen, rich 25 to 35 parts of hydrogen-enriched water, 0.1 to 0.5 parts of hyaluronic acid, and 1 to 5 parts of superoxide dismutase, wherein the trace element composition is one or two of zinc gluconate and sodium selenite, Hydrogen-rich and oxygen-rich water is a mixture of hydrogen-rich water and oxygen-rich water.
2、 根据权利要求 1所述的用于治疗青春痘色素沉斑和美白的精华液, 其特征在于, 所述 微量元素组合物为葡萄糖酸锌和亚硒酸钠按照质量比 (5~10): 1组合而成。 2. The essence for treating acne pigmentation spots and whitening according to claim 1, characterized in that the trace element composition is zinc gluconate and sodium selenite in a mass ratio of (5 to 10) : 1 combination.
3、 根据权利要求 1所述的用于治疗青春痘色素沉斑和美白的精华液, 其特征在于, 所述 富氢富氧水为质量比 1: ( 1-3 ) 的富氢水和富氧水的组合。 3. The essence for treating acne pigmentation spots and whitening according to claim 1, characterized in that the hydrogen-rich and oxygen-rich water is hydrogen-rich water and hydrogen-rich water with a mass ratio of 1: (1-3) A combination of oxygen and water.
4、 根据权利要求 1所述的用于治疗青春痘色素沉斑和美白的精华液, 其特征在于, 所述 富氢水其含氢浓度为 0.9~1.2ppm, 所述富氧水其溶解氧浓度为 20~50ppm。 4. The essence for treating acne pigmentation spots and whitening according to claim 1, characterized in that the hydrogen-rich water has a hydrogen concentration of 0.9~1.2ppm, and the oxygen-rich water has dissolved oxygen The concentration is 20~50ppm.
5、根据权利要求 1~4任一项所述的用于治疗青春痘色素沉斑和美白的精华液, 其特征在 于, 所述精华液还含有 5~10质量份中药组合物, 所述中药组合物由如下药材配方的 各组分提取制得: 木槿花 1~5质量份、 草石蚕 2~5质量份、 牡丹根皮 1~3质量份、 甘 草 2~6质量份、 白茯苓 1~4质量份。 5. The essence for treating acne pigmentation spots and whitening according to any one of claims 1 to 4, characterized in that the essence also contains 5 to 10 parts by mass of a traditional Chinese medicine composition, and the traditional Chinese medicine The composition is prepared by extracting each component of the following medicinal material formula: 1 to 5 parts by mass of hibiscus flower, 2 to 5 parts by mass of caddis fly, 1 to 3 parts by mass of peony root bark, 2 to 6 parts by mass of licorice, and 1 part of white tuckahoe. ~4 parts by mass.
6、 根据权利要求 5所述的用于治疗青春痘色素沉斑和美白的精华液, 其特征在于, 所述 药材配方为: 木槿花 3质量份、草石蚕 4质量份、牡丹根皮 2质量份、甘草 4质量份、 白茯苓 2质量份。 6. The essence for treating acne pigmentation spots and whitening according to claim 5, characterized in that the medicinal material formula is: 3 parts by mass of hibiscus flower, 4 parts by mass of caddisfly, 2 parts by mass of peony root bark. parts by mass, 4 parts by mass of licorice, and 2 parts by mass of Poria cocos.
7、 根据权利要求 5所述的用于治疗青春痘色素沉斑和美白的精华液, 其特征在于, 所述 中药组合物按照如下步骤的提取工艺制得: 7. The essence for treating acne pigmentation spots and whitening according to claim 5, characterized in that the traditional Chinese medicine composition is prepared according to the following extraction process:
1 )按药材配方称取各味药材, 将草石蚕、 牡丹根皮和白茯苓粉碎成粉末后与木槿花、 甘草混合, 加入去离子水室温浸泡 4~8 小时, 所加去离子水的水量为药材总质量的 4-6倍; 1) Weigh each medicinal material according to the medicinal material formula, crush the caddisfly, peony root bark and white tuckahoe into powder, mix with hibiscus and licorice, add deionized water and soak at room temperature for 4 to 8 hours. The amount of deionized water added The amount of water is 4-6 times the total mass of medicinal materials;
2) 之后在 60~70°C下加热煎煮 3~5小时, 过滤并保留滤液。
2) Then heat and cook at 60~70°C for 3~5 hours, filter and retain the filtrate.
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CN105078874B (en) * | 2015-09-01 | 2018-02-02 | 嘉文丽(福建)化妆品有限公司 | A kind of toner for coordinating hydrogen-rich instrument to use and a kind of preparation method of the toner rich in hydrogen |
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KR20120095296A (en) * | 2011-02-18 | 2012-08-28 | (주)아모레퍼시픽 | Cosmetic composition for improving skin tone or skin elasticity |
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CN102641223A (en) * | 2011-02-18 | 2012-08-22 | 株式会社爱茉莉太平洋 | Cosmetic composition for improving skin tone or skin elasticity |
CN102204878B (en) * | 2011-05-04 | 2012-05-30 | 北京华夏美枫化妆品技术中心 | Skin-care composition and preparation with whitening effect and preparation method thereof |
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US20080207774A1 (en) * | 2006-08-24 | 2008-08-28 | Venkataram Krishnan | Anionic latex as a carrier for active ingredients and methods for making and using the same |
US20110064682A1 (en) * | 2008-05-07 | 2011-03-17 | Myeong Jin Nam | Cosmetic composition comprising a stem-cell culture fluid, and a production method therefor |
CN101987075A (en) * | 2009-08-04 | 2011-03-23 | 高凤霞 | Acne treatment composite and use method thereof |
KR20120095296A (en) * | 2011-02-18 | 2012-08-28 | (주)아모레퍼시픽 | Cosmetic composition for improving skin tone or skin elasticity |
CN102258445A (en) * | 2011-07-14 | 2011-11-30 | 陈俊杰 | SOD (superoxide dismutase) collagen peptide facial-beautification anti-aging agent |
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