CN102641223A - Cosmetic composition for improving skin tone or skin elasticity - Google Patents
Cosmetic composition for improving skin tone or skin elasticity Download PDFInfo
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Abstract
The invention provides a cosmetic composition, which has heavy-oxygen-enriched water as an active component. The cosmetic composition further has one of the seeweed type extract and the vegetable extract with raphanin as the active component. The cosmetic composition in the invention can increase the regenerating capacity and the purifying capacity of skin cells to the maximum. Thus the cosmetic composition has advantages of excellent skin tone improvement and skin elasticity increase.
Description
Technical field
The cosmetic composition that the present invention relates to improve the colour of skin or increase skin elasticity.
Background technology
Everyone hopes to avoid old and feeble, but does not also find to prevent aged perfect method biologically so far.Therefore, the activity degree of Skin Cell and regeneration capacity descend with advancing age, the skin aging that pigment calmness such as nevus, freckle, senile plaque and skin elasticity reduce occurs.This phenomenon is not only according to intrinsic factor, inherited genetic factors, and according to environmental factors, shows difference on one's body at everyone.
Therefore, need find out the material that can prevent to show different skin aginges on one's body, and then require to develop the cosmetics that utilize natural goods mass-energy to improve the colour of skin and increase skin elasticity at everyone.
Patent documentation: Korea S publication 10-2009-0091505
Summary of the invention
The objective of the invention is to, provide a kind of and contain as effective ingredient, thereby can improve the colour of skin and increase the cosmetic composition of skin elasticity with heavy-oxygen-enriched water, seaweeds extract or the vegetable extract that contains sulforaphen.
In order to achieve the above object, the present invention provides a kind of cosmetic composition, wherein, contains heavy-oxygen-enriched water as effective ingredient, also contains to be selected from the seaweeds extract and to contain in the vegetable extract of sulforaphen more than one as effective ingredient.
Cosmetic composition of the present invention can farthest increase the regeneration capacity and the detergent power of Skin Cell, has the excellent effect of improving the colour of skin and increase skin elasticity.
Description of drawings
Last activity when Fig. 1 representes that the proteasome inhibitor at cosmetic composition of one embodiment of the invention exists is the photo of the protein residue (black part) in the Skin Cell.
Fig. 2 is that the colour of skin of cosmetic composition of expression one embodiment of the invention is proposed brightness (
) (a) and the chart of the colour of skin uniformity (b) effect.
Fig. 3 is the photo (before using (a), using back (b)) that the colour of skin of the cosmetic composition of expression one embodiment of the invention changes.
Fig. 4 is the chart that the fine skin texture of the cosmetic composition of expression one embodiment of the invention improves effect.
Fig. 5 is the photo (#6:6 experimenter, #14:14 experimenter) that the fine skin texture of the cosmetic composition of expression one embodiment of the invention changes.
Fig. 6 is the chart of skin moisture content of the cosmetic composition of expression one embodiment of the invention.
The specific embodiment
Specify the present invention below.
One embodiment of the invention provide a kind of cosmetic composition, wherein, contain heavy-oxygen-enriched water as effective ingredient, also contain to be selected from the seaweeds extract and to contain in the vegetable extract of sulforaphen more than one as effective ingredient.
In one embodiment of this invention, with respect to composition total weight, above-mentioned heavy-oxygen-enriched water can contain with the ratio of 0.1～80 weight %.This be because, with respect to composition total weight, above-mentioned heavy-oxygen-enriched water is during less than 0.1 weight %, the activation effect of moistening effect and Skin Cell is very little; When surpassing 80 weight %, effect can not significantly improve again, makes the service efficiency of raw material reduce, and the dosage form usability is poor, therefore reduces the value as cosmetics.
In one embodiment of this invention, with respect to composition total weight, above-mentioned seaweeds extract can contain with the ratio of 0.001～10 weight %.
In one embodiment of this invention, with respect to composition total weight, above-mentioned vegetable extract can contain with the ratio of 0.001～10 weight %.
With respect to composition total weight, above-mentioned seaweeds extract and vegetable extract content separately are difficult to expect the purification and the regeneration effect of Skin Cell during less than 0.001 weight %; When surpassing 10.0 weight %, effect can not significantly improve again, makes the service efficiency of raw material reduce, and possibly produce stimulation to skin.
In one embodiment of this invention, above-mentioned heavy-oxygen-enriched water is to instigate dissolved oxygen soluble in water to be dissolved to supersaturation concentration and to contain the more water of polyoxy than general water.Directly supply to this water that contains high concentration oxygen on the skin; Can promote the breathing and the activating cell of Skin Cell; Improve the renewal of moisture-retaining capacity, slow down aging, promotion skin, thereby promote to discharge the melanin that generates in the skin, thereby can show whitening effect.Above-mentioned heavy-oxygen-enriched water can use and be selected from deep seawater, glacial epoch water, subsoil water, thermal water and the distilled water more than one, can preferably use glacial epoch water.Various compositions such as the mineral that contains in the various water of deep seawater, glacial epoch water, subsoil water, thermal water and distilled water and so on can bring effect such as preserve moisture, whiten to skin.
The deep regions of bathypelagic water extraction below the about 200m of the depth of water.Superficial water is the nitrogen in the consume water, phosphorus, nitric acid etc. owing to carry out photosynthesis, but sunlight can't arrive deep regions, so do not consume the vegetalitas plankton of nutrient substance, photosynthesis takes place hardly.Therefore, kept because of inorganic nutrients salts such as nitrogen that photosynthesis consumes, phosphorus, nitric acid.In addition, deep seawater is rich in the mineral of needed by human or essential trace element, helps to replenish the mineral that lacks easily, and has the characteristics such as elimination action effect to the brilliance of active oxygen through the effect of dissolved metal ion.In addition, deep seawater does not receive the pollution of escherichia coli or common bacteria, receives from the contamination of heavy of land or atmospheric chemical substance few yet.In addition, deep seawater keeps low temperature throughout the year, and variations in temperature is little, has the characteristics of stable and low water temperature, owing to be the water that formed through thousands of years, so its stable in properties.
Glacial epoch water is meant and does not dissolve through the snow in tens million of years years in high mountain or polar region and accumulate the formation firn, becomes hard ice through pressure, and the water that generates thus.At present; Polar region or alpine belt that the glacial epoch water distribution is the most peace and quiet on earth; Signifying the health of nature and pure vitality, Ecuadorian Bill Ka Banba, the rare Sa areas of the Abkhazia in Caucasia and Himalaya etc. are known to be that representative glacial epoch water generates the area.Be difficult to propagate microorganisms or pathogen in these glacial epoch water, the ratio of hexagonal water is high on the structure, and rich in mineral substances.This mineral to keeping osmotic pressure and acid-base balance, is participated in the healing and the internal metabolism function of wound in vivo, in oxygen transmission and Cellular respiration, plays an important role.
In one embodiment of this invention, above-mentioned heavy-oxygen-enriched water can contain the dissolved oxygen of 20～200ppm.Above-mentioned heavy-oxygen-enriched water can be through utilizing gas stone (air stone) and so on the oxygen infusion appliance with 1～10kg/cm
2Pressure 1～10 time and in the water of above-mentioned glacial epoch, inject the method that oxygen makes and improve dissolved oxygen content repeatedly through 10～120 minutes.In order to improve Gas Solubility, preferred above-mentioned heavy-oxygen-enriched water is made under cryogenic conditions, but is not limited to this.
In one embodiment of this invention, above-mentioned seaweeds extract can use more than one the extract that is selected from green algae, red algae, Brown algae and the microalgae; Preferred one or more the extract that is selected from Brown algae and the microalgae that uses; More preferably be selected from as the Laminaria digitata Lamx of Brown algae with as more than one the extract in the spirulina of microalgae.Seaweeds is to have chlorophyll and in water, carry out photosynthetic plant, has adapted to become and can in the extreme environment of oceans such as high salinity, high pressure, solar heat, survive.Seaweeds comprises that the unicellular organism body surpasses the multiple kind of 100 meters Thallus Laminariae (Thallus Eckloniae) to length.Seaweeds contains multiple compositions such as vitamin, mineral, cellulose, has antioxidation, improves wrinkle, multiple effects such as whiten.
In one embodiment of this invention, above-mentioned seaweeds extract can also can be bought commercially available seaweeds extract and use through any method for distilling manufacturing well known in the art.Particularly, can use ethanol, methanol, butanols, ether, ethyl acetate, chloroform, dichloromethane, water or their mixed solvent to extract.In addition, it is also understood that to being included in this extract with the further meaning made from extra care the fraction that obtains of above-mentioned solvent.No matter use which kind of method for distilling, so long as extract through being impregnated into the step of extracting in the solvent as the seaweeds that extracts object, method for distilling all can use any means such as merceration, backflow, heating, ultrasound wave.Extract preferred 10～80 ℃ of temperature, can extract 6～24 hours.When surpassing said extracted temperature and extraction time, possibly cause extraction efficiency to reduce or the composition variation.The amount of employed seaweeds can change according to employed method and expense in any one extraction process, is preferably the scope of about 1～50 weight %.
In one embodiment of this invention; The vegetable that the above-mentioned vegetable that contains sulforaphen can be used Cruciferae; For example can use and be selected from Caulis et Folium Brassicae capitatae, Brassica Oleracea Var.Acephala, Brassica oleracea L.var.capitata L., Radix Raphani, Radix Brassicae rapae, Brassica oleracea L. var. botrytis L., Turnip Sprouts and the blue or green stalk dish more than one; Good because the content of sulforaphen is many to skin, more than one in therefore preferred use Caulis et Folium Brassicae capitatae and the Radix Brassicae rapae.The sulforaphen composition is the composition that is rich in the brassicaceous vegetable, is known material with powerful antioxidant effect, shows anticancer and effects such as antiphlogistic effects, the UV-induced skin erythema of minimizing.
In one embodiment of this invention, above-mentioned vegetable extract can also can be bought commercially available vegetable extract and use through any method for distilling manufacturing well known in the art.Particularly, can use ethanol, methanol, butanols, ether, ethyl acetate, chloroform, dichloromethane, water or their mixed solvent to extract.In addition, it is also understood that to being included in this extract with the further meaning made from extra care the fraction that obtains of above-mentioned solvent.No matter use which kind of method for distilling, so long as extract through being impregnated into the step of extracting in the solvent as the vegetable of extracting object, method for distilling all can use any means such as merceration, backflow, heating, ultrasound wave.Extract preferred 10～80 ℃ of temperature, can extract 6～24 hours.When surpassing said extracted temperature and extraction time, possibly cause extraction efficiency to reduce or the composition variation.The amount of employed vegetable can change according to employed method and expense in any one extraction process, is preferably the scope of about 1～50 weight %.
In one embodiment of this invention, above-mentioned composition can contain heavy-oxygen-enriched water, Laminaria digitata Lamx extract, spirulina extract, Caulis et Folium Brassicae capitatae and Radix Brassicae rapae extract as effective ingredient.
In one embodiment of this invention, above-mentioned cosmetic composition can be the cosmetic composition that is used to improve the colour of skin.Above-mentioned cosmetic composition increases human skin cell's proteasome activity, prevents skin aging and improves the colour of skin.
In one embodiment of this invention, above-mentioned cosmetic composition can be the cosmetic composition that is used to increase skin elasticity.Above-mentioned cosmetic composition promotes the biosynthesis of human skin cell's collagen protein, increases skin elasticity.
The cosmetic compositions of of the present inventionization can adopt solution; Emulsion; Cementitious mixtures forms such as (
).Promptly; Do not receive special restriction on the dosage form, can manufacture for example toner/smoothing toner, firming lotion, nutrition astringent, nourishing cream, massage cream, eye cream, eye elite, elite, cleansing cream, cleaning breast, cleaning foam, clean water, facial film, powder, sun screen, foundation cream, health breast, cosmetics such as health is white, health is oily, health elite, clean body agent, beautifying liquid, fancy soap, emulsion, dew, ointment gel, frost, patch, spray.
Cosmetic composition of the present invention do not influence the object of the invention in the scope of the main effect that will reach; Can also contain other composition that can improve the main effect of the present invention, their concrete kind and content are known for a person skilled in the art.Those skilled in the art can be according to known common composition and content and are easily suitably selected and cooperate.
Below, specify the present invention with reference to manufacturing example of the present invention, embodiment and Test Example.Clear and definite to those skilled in the art is, these make example, embodiment and Test Example only is the illustration of carrying out in order more specifically the present invention to be described, scope of the present invention does not limit thus.
Make example 1: utilize glacial epoch water to make heavy-oxygen-enriched water
Utilize gas stone with 1kg/cm
2Pressure ultra-high purity oxygen is carried out 1 time in the glacial epoch water of 20 fens clockwise 20kg and injects.With after the water quench to 15 ℃, with 2kg/cm
2Pressure through 10 minutes ultra-high purity oxygen is carried out 2 times and injects, be cooled to 15 ℃ after, with 3kg/cm
2Pressure after 10 minutes oxygen with ultra-high purity carries out injecting for 3 times, seal and make the extract that has increased dissolved oxygen.Utilize dissolved oxygen meter (HI964400, HANNA instrument ITALY) measure the oxygen concentration of ordinary dissolution of said extracted thing, results verification the dissolved concentration of oxygen be 32ppm.
Make example 2: utilize distilled water to make heavy-oxygen-enriched water
Utilize gas stone with 1kg/cm
2Pressure ultra-high purity oxygen is carried out 1 time in the distilled water of 20 fens clockwise 20kg and injects.With after the water quench to 15 ℃, with 2kg/cm
2Pressure through 10 minutes ultra-high purity oxygen is carried out 2 times and injects, be cooled to 15 ℃ after, with 3kg/cm
2Pressure after 10 minutes oxygen with ultra-high purity carries out injecting for 3 times, seal and make the extract that has increased dissolved oxygen.Utilize dissolved oxygen meter (HI964400, HANNA instrument ITALY) measure oxygen concentration of ordinary dissolution in the said extracted thing, results verification the dissolved concentration of oxygen be 33ppm.
Make example 3: the manufacturing of Laminaria digitata Lamx and spirulina extract
The Laminaria digitata Lamx of 1kg and spirulina joined among 70% the ethanol 5l, after the reflux, extract, 3 times, 15 ℃ of dippings 1 day.Then; Residue is separated with filtrating with centrifugalize through the filter cloth filtration; Separate the filtrating that obtains and obtain concentrated solution through concentrating under reduced pressure; Above-mentioned concentrated solution suspendible in the water of 1l, is used the dichloromethane extraction 5 times of 1l then, the dichloromethane layer that concentrating under reduced pressure obtains thus and obtained the seaweeds extract of 350g.
Make example 4: the manufacturing of Entermorpha
extract
The Entermorpha of 1kg joined among 70% the ethanol 5l, after the reflux, extract, 3 times, 15 ℃ of dippings 1 day.Then, filter with centrifugalize through filter cloth residue is separated with filtrating, the filtrating that separation obtains obtains concentrated solution through concentrating under reduced pressure, and above-mentioned concentrated solution suspendible in the water of 1l, is used the dichloromethane extraction 5 times of 1l then.The dichloromethane layer that concentrating under reduced pressure obtains thus and obtained the seaweeds extract of 300g.
Make example 5: the manufacturing of Caulis et Folium Brassicae capitatae and Radix Brassicae rapae extract
With utilizing pulverizer to pulverize after the Caulis et Folium Brassicae capitatae of 1kg and the Radix Brassicae rapae lyophilization, join then among 70% the ethanol 2l, 15 ℃ of dippings 1 day.After impregnation liquid carried out 3 reflux, extract, once more, utilize filter cloth to filter and obtained the vegetable extract of 200g.
Make example 6: the manufacturing of cauliflower extract
Utilize pulverizer to pulverize after the Brassica oleracea L. var. botrytis L. lyophilization with 1kg, join then among 70% the ethanol 2l, 15 ℃ of dippings 1 day.After impregnation liquid carried out reflux, extract, 3 times once more, utilize filter cloth to filter and obtained the vegetable extract of 200g.
Test Example 1: to human skin cell's collagen protein biosynthesis effect
Cultivating people's fibroblast in 24 well culture plates; Be replaced by the culture medium that contains each compositions then, cultivate after 3 days, in every hole, add the DMEM culture medium 0.5ml that contains 10% hyclone respectively with the concentration shown in following table 1; Add L [2 then; 3,4,5-3H]-proline 10 μ Ci.After 24 hours, collect culture medium and cell in each hole, trichloroacetic acid (TCA with 5%; Trichloroacetic acid) behind the solution washing, be injected into respectively in two test tubes, add type i collagen enzyme (type I collagenase) 1 unit/μ l in the test tube, under 37 ℃, cultivated 90 minutes, another test tube is 4 ℃ of keepings down.Then, in all test tubes, add 50% trichloroacetic acid 0.05ml respectively, 4 ℃ of held after 20 minutes respectively with 12,000rpm centrifugalize 10 minutes utilizes liquid scintillation counter (LSC; Liquid Scintillation Counter) measures CPM (counts per minute) value in each supernatant and the deposition, and, obtain collagen biosynthesis value (RCB for matched group and experimental group according to following mathematical expression 1; Relative Collagen Biosynthesis).Its result, with matched group be 100 obtain fiducial value after, the collagen biosynthesis rate (RCB) that will change according to the time (%) is shown in table 1.
Mathematical expression 1
Table 1
| Concentration (ppm) | Matched group | Make example 1 | Make example 2 | Make example 3 | Make example 4 |
| 10 | 100 | 110 | 104 | 120 | 108 |
| 1 | 100 | 105 | 101 | 108 | 103 |
Can know from the result of last table 1; Heavy-oxygen-enriched water (make example 1,2) and seaweeds extract (making example 3,4) can concentration dependent ground increase collagen protein biosynthesis; Especially, can know that having increased the glacial epoch of dissolved oxygen water (manufacturing example 1), Laminaria digitata Lamx and spirulina extract (making example 3) increases the biosynthetic degree excellence of collagen protein.Can obtain increasing the effect of skin elasticity thus.
Experimental example 2: the effect that increases HF's proteasome activity
For the effect of confirming that the said extracted thing increases proteasome activity,, use 20mM Tris-HCl (pH7.8), 5mM MgCl then with the compositions-treated normal person fibroblast shown in the following table 2 48 hours
2, 10mM KCl, 1mM DTT buffer collect and destroy with ultrasound wave, obtained supernatant at 4 ℃ in 10 minutes with the 12000rpm centrifugalize then.For quantitative protein, use BSA (bovine serum albumin) as standard substance, through bicinchoninic acid (bicinchoninic acid) (Pierce) method measured albumen quality.In order to measure the most representative Chymotrypsin appearance active (chymotrypsin-like activity) in 3 kinds of activity that show proteasome activity; Add the protein of 30 μ g and as (LLVY-AMC) each 50 μ l of 100 μ M (ultimate density) of the succinyl group-leucyl-leucyl-valyl-tyrosine-7-amido-4-methylcoumarin (succinyl-Leu-Leu-Val-Tyr-7-amino-4-methylcoumarin) of fluorescence peptide zymolyte; After making final volume reach 100 μ l, 37 ℃ of held in the dark 30 minutes.Active in through being arranged to excitation wavelength (excitation wavelength) 380nm, discharging the fluorescence intensity that the spectrofluorometer of wavelength (emission wavelength) 460nm measures and represent.In order to eliminate the part that shows with dependent/non-dependent proteasome ground above-mentioned enzymatic activity; (Biomol, PI-102) last during 20 μ M activity is replenished
in overall activity, calculates will to have proteasome inhibitor MG132.The result who measures this proteasome activity degree is shown in table 2 and table 3, the protein residue (black part) in the Skin Cell of observing is shown in Fig. 1.
Table 2 is to use separately the situation of the heavy-oxygen-enriched water of being made by glacial epoch water (making example 1) and unite the comparison of effect of the situation (embodiment 1) of use with Caulis et Folium Brassicae capitatae and Radix Brassicae rapae extract, and table 3 is to use the situation of the heavy-oxygen-enriched water of being made by distilled water (making example 2) separately and unite the comparison of effect of the situation (embodiment 2) of use with cauliflower extract.
Table 2
Table 3
From table 2 and table 3, can know, compare the situation of independent use heavy-oxygen-enriched water, increase the heavy-oxygen-enriched water of dissolved oxygen and unite among embodiment 1 and the embodiment 2 when using with vegetable extract, proteasome activity increases; Unite among the embodiment 1 of use with the heavy-oxygen-enriched water of glacial epoch water manufacturing with Caulis et Folium Brassicae capitatae and Radix Brassicae rapae extract, the proteasome activity increase is more obvious.Can confirm that from Fig. 1 proteasome activity concentration dependent ground increases progressively.Therefore, through being responsible for the activation of the proteasome of cleaning (Cleansing) in the cell, can improve skin aging and put forward the bright colour of skin.
Embodiment 3～7 and Comparative Examples 1
Utilize the extract of above-mentioned manufacturing example 1～6, made the cosmetic composition (unit: weight %) that improves the colour of skin or increase skin elasticity of being used to through following method with the composition shown in the table 4.
Table 4
At normal temperatures, after the aqueous phase adding solubilising phased soln of being dissolved into transparent and tackify is even, joins and make in the example 1～6, dissolving is even, has made the cosmetic composition of embodiment 3～7.In addition, Comparative Examples 1 is not make example 1～6 and make through not adding in mutually at extract.
Experimental example 3: to improving the evaluation of complexion
For the influence of the cosmetic composition confirming in the foregoing description 3～6 and the Comparative Examples 1 to make to the colour of skin, be object with 35 healthy womens of 20～40 years old, be divided into 5 groups with every group 7 people and experimentize.Use the dosage form of embodiment 3～6 and Comparative Examples 1 respectively to each group; After continuing every day 2 times 4 weeks evenly to be coated to entire face; After 4 weeks, utilize chromascope (Minolta CM-3500d) to measure color and luster brightness flop (Δ L), thereby estimate the degree of improving the colour of skin; Its result is as shown in table 5 below, and the numerical value of being put down in writing in the table 5 is the meansigma methods of each group.
Table 5
| Substances | The colour of skin is improved degree (Δ L) |
| Embodiment 3 | 3.7 |
| Embodiment 4 | 4.2 |
| Embodiment 5 | 1.8 |
| Embodiment 6 | 2.0 |
| Comparative Examples 1 | 1.5 |
In the result of above-mentioned table 5, the Comparative Examples 1 that does not contain extract shows minimum effect, is superior to Comparative Examples 1 though contain the embodiment 5,6 of the extract of making example 2,4,6, has shown 3, the 4 low-level effects than embodiment.On the other hand; Can confirm to contain the embodiment 3,4 that increases the glacial epoch of dissolved oxygen water, Laminaria digitata Lamx and spirulina extract, Caulis et Folium Brassicae capitatae and Radix Brassicae rapae extract compares embodiment 5,6 and Comparative Examples 1 and shows that high complexion improves effect; Especially, contain the embodiment 4 that increases the glacial epoch of dissolved oxygen water, Caulis et Folium Brassicae capitatae and Radix Brassicae rapae extract and show the most excellent effect.
Test Example 4: increase the skin elasticity Evaluation on effect
For confirming the skin elasticity recovery effects of the foregoing description 3～6 and Comparative Examples 1, be object with 25 30～40 years old women, be divided into 5 groups, every group 5 people measures.The dosage form of embodiment 3～6 and Comparative Examples 1 is used in every group, and after continuing every day 2 times 4 weeks evenly to be coated to entire face, the back utilizations of 4 weeks can be measured the skin elasticity analyzer (cutometer of skin elasticity; SEM474, Courage+Khazaka electronic GmbH.Germany) measure face's elasticity, and compare before with coating, its result is shown in the following table 6.
Table 6
| Substances | Skin elasticity degree of improvement (%) |
| Embodiment 3 | 75 |
| Embodiment 4 | 71 |
| Embodiment 5 | 50 |
| Embodiment 6 | 47 |
| Comparative Examples 1 | 43 |
Can confirm from last table 6; The skin elasticity of embodiment 3～6 is improved effect and is superior to Comparative Examples 1; Embodiment 3,4 is superior to embodiment 5,6, and especially, it is the most excellent that the skin elasticity that contains the embodiment 3 that increases the glacial epoch of dissolved oxygen water, Laminaria digitata Lamx and spirulina extract is improved effect.
Test Example 5: complexion is improved Evaluation on effect
For the colour of skin of confirming the foregoing description 7 is improved effect, be object with 20 women of 41 ± 3 years old, measure skin photo (outside, internal reflection, optics), analyze the colour of skin and put forward the brightness and the colour of skin uniformity.After wash one's face twice of experimenter every day (early, evening), evenly be coated to entire face, after thermostatic constant wet chamber waits for 15 minutes, measure in the skin protection phase I (before using surfactant).
Preceding to using, used for 2 weeks and use the colours of skin after 4 weeks to propose brightness and the colour of skin uniformity is measured.Its result is at following Fig. 2, shown in 3.As shown in Figure 2, propose brightness to have confirmed to have after using for 2 weeks be 1.7%, be 1.9% remarkable improvement after using for 4 weeks for the colour of skin.Confirmed after using for 2 weeks to be 2.8%, be 4.3% improvement trend after using for 4 weeks for the colour of skin uniformity.In addition, can confirm that from Fig. 3 the general red obscure colour of skin is improved as bright.
Test Example 6: improve the skin texture Evaluation on effect
Improve the skin texture effect for what confirm the foregoing description 7, estimate the Skin Cell regeneration that oxygen supply brings through the improvement of trickle skin texture.With 20 41 ± 3 years old women is object, utilizes three-dimensional skin pattern appearance (3D skin topography) to carry out skin texture is improved evaluation.Identical with embodiment 5, after wash one's face twice of experimenter every day (early, evening), evenly be coated to entire face in the skin protection phase I (before using surfactant),, thermostatic constant wet chamber measures after waiting for 15 minutes.
Its as a result infra Fig. 4, shown in 5.As shown in Figure 4, can confirm to demonstrate after 2 weeks skin texture and improve 5% remarkable improvement.In addition, can confirm that original lineolate skin texture reverts to slick skin surface among Fig. 5 (#6:6 experimenter, #14:14 experimenter).
Test Example 7: the evaluation of skin moisture content
For the effect of the increase skin moisture content of confirming the foregoing description 7, be object with 20 41 ± 3 years old women, carried out the mensuration of moisture improvement rate (%) through measuring facial moisture.Identical with embodiment 5, after wash one's face twice of experimenter every day (early, evening), evenly be coated to entire face in the skin protection phase I (before using surfactant),, thermostatic constant wet chamber measures after waiting for 15 minutes.
Its result is shown in Fig. 6.As shown in Figure 6, can confirm to have demonstrated that to use after 2 weeks be to be 13.5% remarkable improvement after 10.8%, 4 weeks.
That is, can confirm that the first step in skin protection uses cosmetic composition of the present invention to promote the absorption of oxygen composition, thereby fine skin texture is got well and give moistening effect, thereby the effect of putting forward the bright colour of skin is very excellent.
The following dosage form example of explanation cosmetic composition of the present invention, but except following illustrative, can also use with other various dosage forms, this is not to be used to limit the present invention and just to be used to specify.
Dosage form example 1: toner/smoothing toner (skin cream)
Made toner/smoothing toner according to forming shown in the following table 7 according to usual method.
Table 7
Dosage form example 2: nutrition astringent (nutritional emulsions)
Composition according to shown in the following table 8 has been made the nutrition astringent according to usual method.
Table 8
Dosage form example 3: nourishing cream
Composition according to shown in the following table 9 has been made nourishing cream according to usual method.
Table 9
Dosage form example 4: massage cream
Composition according to shown in the following table 10 has been made massage cream according to usual method.
Table 10
Dosage form example 5: facial film
Composition according to shown in the following table 11 has been made facial film according to usual method.
Table 11
Dosage form example 6: patch
Composition according to shown in the following table 12 has been made patch according to usual method.
Table 12
Those skilled in the art can be the basis with the foregoing, carry out various application and distortion within the scope of the invention.
More than characteristic of the present invention is specified, but these contents only are preferred embodiment to those skilled in the art, scope of the present invention does not limit thus.Therefore, substantial scope of the present invention should be confirmed by invention which is intended to be protected.
Claims (16)
1. a cosmetic composition is characterized in that,
Contain heavy-oxygen-enriched water as effective ingredient,
Contain and be selected from the seaweeds extract and contain in the vegetable extract of sulforaphen more than one as effective ingredient.
2. cosmetic composition according to claim 1 is characterized in that,
With respect to composition total weight, said heavy-oxygen-enriched water contains with the ratio of 0.1～80 weight %;
With respect to composition total weight, said seaweeds extract contains with the ratio of 0.001～10 weight %;
With respect to composition total weight, said vegetable extract contains with the ratio of 0.001～10 weight %.
3. cosmetic composition according to claim 1 is characterized in that said heavy-oxygen-enriched water contains the dissolved oxygen of 20～200ppm.
4. cosmetic composition according to claim 3 is characterized in that, said heavy-oxygen-enriched water be in being selected from deep seawater, glacial epoch water, subsoil water, thermal water and distilled water more than one with the oxygen infusion appliance with 1～10kg/cm
2Pressure injected oxygen manufacturing 1～10 time repeatedly through 10～120 minutes.
5. cosmetic composition according to claim 1 is characterized in that, said seaweeds is to be selected from green algae, red algae, Brown algae and the microalgae more than one.
6. cosmetic composition according to claim 1 is characterized in that, said seaweeds is to be selected from Brown algae and the microalgae more than one.
7. cosmetic composition according to claim 1 is characterized in that, said seaweeds is to be selected from Laminaria digitata Lamx and the spirulina more than one.
8. cosmetic composition according to claim 1 is characterized in that, the said vegetable that contains sulforaphen is a brassicaceous vegetable.
9. cosmetic composition according to claim 8 is characterized in that, said brassicaceous vegetable is to be selected from Caulis et Folium Brassicae capitatae, Brassica Oleracea Var.Acephala, Brassica oleracea L.var.capitata L., Radix Raphani, Radix Brassicae rapae, Brassica oleracea L. var. botrytis L., Turnip Sprouts and the blue or green stalk dish more than one.
10. cosmetic composition according to claim 8 is characterized in that, said brassicaceous vegetable is to be selected from Caulis et Folium Brassicae capitatae and the Radix Brassicae rapae more than one.
11. cosmetic composition according to claim 1 is characterized in that, said compositions contains heavy-oxygen-enriched water, Laminaria digitata Lamx extract, spirulina extract, Caulis et Folium Brassicae capitatae and Radix Brassicae rapae extract as effective ingredient.
12. cosmetic composition according to claim 1; It is characterized in that said seaweeds extract or the vegetable extract that contains sulforaphen are to use ethanol, methanol, butanols, ether, ethyl acetate, chloroform, dichloromethane, water or their mixed solvent to extract.
13. cosmetic composition according to claim 1 is characterized in that, said cosmetic composition is the cosmetic composition that is used to improve the colour of skin.
14. cosmetic composition according to claim 13 is characterized in that, said cosmetic composition increases human skin cell's proteasome activity, prevents skin aging and improves the colour of skin.
15. cosmetic composition according to claim 1 is characterized in that, said cosmetic composition is the cosmetic composition that is used to increase skin elasticity.
16. cosmetic composition according to claim 15 is characterized in that, said cosmetic composition promote the human skin cell collagen protein biosynthesis and increase skin elasticity.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2011-0014740 | 2011-02-18 | ||
| KR20110014740 | 2011-02-18 | ||
| KR10-2012-0009404 | 2012-01-31 | ||
| KR1020120009404A KR101972071B1 (en) | 2011-02-18 | 2012-01-31 | Cosmetic composition for improving skin tone or skin elasticity |
Publications (1)
| Publication Number | Publication Date |
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| CN102641223A true CN102641223A (en) | 2012-08-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100392013A Pending CN102641223A (en) | 2011-02-18 | 2012-02-17 | Cosmetic composition for improving skin tone or skin elasticity |
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| CN (1) | CN102641223A (en) |
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