WO2015010373A1 - Facial mask used for treatment of acne hyperpigmentation spot and for whitening - Google Patents

Facial mask used for treatment of acne hyperpigmentation spot and for whitening Download PDF

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Publication number
WO2015010373A1
WO2015010373A1 PCT/CN2013/085016 CN2013085016W WO2015010373A1 WO 2015010373 A1 WO2015010373 A1 WO 2015010373A1 CN 2013085016 W CN2013085016 W CN 2013085016W WO 2015010373 A1 WO2015010373 A1 WO 2015010373A1
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parts
hydrogen
oxygen
mass
rich
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PCT/CN2013/085016
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French (fr)
Chinese (zh)
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陈俊杰
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彭海英
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212Face masks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365Hydroxycarboxylic acids; Ketocarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Definitions

  • the invention relates to a mask having the functions of treating acne, diminishing pigmentation spots and having whitening effect.
  • Acne is a skin disease, also known as acne, acne, hemorrhoids or facial sores. It is a kind of puberty development, oily skin, eating fat and sugary foods, spicy food, because of staying up late or working nature. Common skin diseases. The patient has excessive secretion of sebaceous glands, and a large amount of stratum corneum is detached. When mixed with grease and dirt, the pores are blocked, which causes redness and inflammation of the hair follicle. In severe cases, it also causes pigment cells to proliferate, leaving pigmentation spots that are difficult to eliminate, and affecting the appearance of patients.
  • cosmetics for treating pigmentation caused by acne and acne are mostly used by adding chemical fungicides, hormones, etc., although these components can sterilize or eliminate inflammation in a short time, but are highly irritating to the skin.
  • Long-term use will increase the patient's skin burden, and may even cause skin redness, suppuration or pain, and some will stimulate the further proliferation of pigment cells and aggravate pigmentation spots.
  • How to develop a safer, gentler and more effective skin care product for treating acne and diminishing pigmentation has become one of the urgent breakthroughs in the field.
  • the object of the present invention is to provide a mask which is less irritating, has no toxic side effects, can effectively eliminate acne and dilute pigmentation spots, and at the same time functions as a whitening effect.
  • a mask for treating acne pigmentation and whitening contains the following components: 1-3 parts of trace element composition, 3 ⁇ 5 parts of collagen, hydrogen-rich oxygen-rich water 25 ⁇ 35 parts, 0.1-0.5 parts of hyaluronic acid, 1 ⁇ 5 parts of superoxide dismutase, 4-6 parts of hydroxyethyl cellulose, 10-20 parts of propylene glycol, 0.05-0.1 parts of preservative; wherein the trace element composition It is one or both of zinc gluconate and sodium selenite, and the hydrogen-rich oxygen-enriched water is a mixture of hydrogen-rich water and oxygen-enriched water.
  • the superoxide dismutase used in the present invention has a specific activity of 1000 to 2000 IU/mg.
  • the preservative is not particularly limited, and a preservative commonly used in the cosmetic field may be selected, for example, DMDM hydantoin, methylparaben or the like may be selected.
  • the trace element composition is a combination of zinc gluconate and sodium selenite according to a mass ratio (5-10):1.
  • the hydrogen-rich oxygen-enriched water is a combination of hydrogen-rich water and oxygen-enriched water having a mass ratio of 1: (1-3).
  • the hydrogen-rich water has a hydrogen (in terms of hydrogen molecules) concentration of 0.9 to 1.2 ppm, and the oxygen-enriched water contains a dissolved oxygen concentration of 20 to 50 ppm.
  • the mask formulation further comprises 5 to 10 parts by mass of the traditional Chinese medicine composition, and the traditional Chinese medicine composition is obtained by extracting the components of the following medicinal material formula: 1 to 5 parts by mass of hibiscus, 2 to 5 parts by mass of sarcophagus 1 to 3 parts by mass of peony bark, 2 to 6 parts by mass of licorice, and 1 to 4 parts by mass of white peony.
  • the medicinal material is formulated as: 3 parts by mass of hibiscus, 4 parts by mass of sarcophagus, 2 parts by mass of peony root, 4 parts by mass of licorice, and 2 parts by mass of peony.
  • the traditional Chinese medicine composition is prepared according to the following extraction process:
  • Collagen is a biological polymer substance, a white, opaque, unbranched fibrous protein. It can replenish the nutrients needed in all layers of the skin, enhance the collagen activity in the skin, and have certain effects on moisturizing the skin, delaying aging, beauty, wrinkle and hair growth.
  • Hydrogen-rich water Also known as Hydrogen Water, it is a Japanese transliteration. Hydrogen itself is one of the best natural antioxidants, so the water added with hydrogen has a strong reducing function. It can neutralize active oxygen (free radicals) in the body's blood and cells. Modern medicine believes that active hydrogen can effectively remove free radicals in the body. Hydrogen-rich water has more antioxidant properties than all known human antioxidants such as vitamin C, carrots, lecithin, etc., for allergic dermatitis, constipation, hypertension, diabetes, cancer. All kinds of symptoms caused by free radicals have a strong preventive effect. Hydrogen-rich water promotes metabolism and allows each cell to maintain a healthy state, remove body rust and delay aging. The preparation method of hydrogen-rich water has been a relatively mature technology, and a method for preparing hydrogen-rich water is described in Chinese Patent Application Publication No. CN102408147A.
  • Oxygen-enriched water refers to water containing more oxygen in which the dissolved oxygen concentration in water is higher than that of ordinary water. By directly supplying the water containing a high concentration of dissolved oxygen to the skin, it can promote the respiratory cells of the skin cells to activate the cells, improve the moisturizing ability, delay the aging, promote the renewal of the skin, and thereby promote the discharge of melanin produced in the skin, thereby displaying Whitening effect.
  • Oxygen-enriched water is a natural anti-microbial preservative and oxygen booster that promotes skin metabolism and promotes overall skin health.
  • the preparation method of the oxygen-enriched water is a well-established technique, and the preparation method of the oxygen-enriched water is described in the Chinese Patent Application Publication No. CN1200355A and the Chinese Patent Application Publication No. WO102641223A.
  • Hyaluronic acid not only has the function of maintaining skin elasticity, but also locks a lot of water molecules, which protects the tissues. Wet lubrication can make the skin full and young and elastic. However, as the age of hyaluronic acid loses faster than the growth rate, the skin will gradually become deficient in moisture, lose luster elasticity, and wrinkles and other aging phenomena will appear in the long run.
  • SOD Superoxide dismutase
  • SOD is a strong redox agent that can react with oxygen free radicals in the body, so that human cell repair and gene organization are not damaged. Anti-aging is constantly supplemented by SOD.
  • the effect of superoxide dismutase (SOD) is a free radical scavenger that scavenges free radicals 02- (superoxide anion radicals), while 02- is cytotoxic, can cause lipid peroxidation, damage cell membranes, cause inflammation , tumors and autoimmune diseases, and may cause the body to age.
  • SOD is a powerful free radical scavenger that inhibits pigment cell deposition and has anti-aging, immune regulation and anti-radiation effects.
  • Hibiscus It is rich in vitamin C, iron, calcium, zinc, selenium and other trace elements, and contains flavonoid active compounds and mucus.
  • the hibiscus extract has the functions of moisturizing, anti-oxidation and scavenging free radicals, and can inhibit Staphylococcus aureus and Salmonella typhi.
  • Grass stone silkworm Also known as silver bar, it is a specialty of Yanshi City, Henan province, China. Its shape and taste are similar to those of green bean sprouts.
  • Grass stone Silkworm is rich in sugar, phenols, vitamin c, crude protein, amino acids, organic acids, etc. It has a unique effect on softening blood vessels, lowering blood and improving blood circulation.
  • Peony root bark dry root bark of peony family of Ranunculaceae.
  • the peony phenol and other glycoside components have anti-inflammatory effects;
  • the methanol extract of peony bark has the effect of inhibiting platelets;
  • peony phenol has central inhibition of sedation, cooling, antipyretic, analgesic, antispasmodic and anti-arterial Atherosclerosis, diuretic, anti-ulcer and so on.
  • the extract of peony root bark has anti-bacterial, anti-inflammatory, acne and whitening effects.
  • Licorice Sweet and flat. Licorice also has anti-inflammatory and anti-allergic effects, which can protect the inflamed throat and tracheal mucosa. Licorice extract and glycyrrhizic acid have a detoxifying effect similar to glucuronic acid to certain poisons. Licorice can clear away heat and detoxify, moisten the lungs and relieve cough, and reconcile various medicinal properties; it has anti-inflammatory, anti-viral, liver-protecting and detoxifying functions and enhances immune function. Relieve the toxicity and potency of the drug.
  • the flavonoids of licorice have anti-inflammatory, antispasmodic and anti-acid effects; the effective component of detoxification is glycyrrhizin, and the detoxification mechanism is the adsorption of glycyrrhizin on poisons.
  • White peony It has whitening and anti-inflammatory properties, protects against UV damage and promotes skin metabolism.
  • a trace element composition collagen, hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase is added to the mask, and these components are compatible according to a specific quality, and have acne Good therapeutic effect, it has a lightening effect on the sun stains, and at the same time plays a whitening effect.
  • a trace element composition formed by a combination of zinc gluconate and sodium selenite, which can supplement zinc and selenium to the skin.
  • Zinc has a role in coordinating immune responses. Zinc is involved in the synthesis of various enzymes such as carbonic anhydrase, alkaline phosphatase, and DNA polymerase, and increases the repair of wound tissue.
  • Selenium is effective The comprehensive antioxidants, while significantly delaying cell aging, simultaneously prevent the denaturation of collagen, which increases the amount of collagen synthesis and reduces its loss.
  • the current research proves that selenium has anti-oxidation effect, scavenging free radicals to protect cell membrane structure and function, and repairing molecular damage sites; selenium can promote various metabolic activities in the body.
  • Selenium is a normal component of muscle and is glutathione peroxidase. Essential ingredients, selenium has the effect of antagonizing and reducing the toxicity of various heavy metals in the human body. Selenium can stimulate the production of immunoglobulins and antibodies and improve the immune function of the body.
  • the hydrogen-rich and oxygen-rich water formed by the mixture of hydrogen-rich water and oxygen-enriched water is rich in active hydrogen and dissolved oxygen, promotes metabolism, enables each cell to maintain a healthy state automatically, effectively removes free radicals in the body, and promotes skin cells. Breathe and activate cells, improve moisturizing ability, promote skin renewal and discharge melanin produced in the skin. Formulated with collagen, hyaluronic acid and superoxide dismutase to replenish moisture and collagen to the skin. SOD acts as a powerful free radical scavenger and inhibits pigment cell deposition.
  • the combination of trace elements, collagen, hydrogen-rich oxygen-enriched water, hyaluronic acid and superoxide dismutase can improve the body's immunity, repair wounds, activate cells, achieve acne, and promote Cell metabolism and inhibition of melanin deposition, to achieve the effect of lightening pigmentation spots.
  • the efficiency of acne can reach 91%
  • the cure rate can reach 70-80%
  • the effective rate of stain can reach 88%
  • the cure rate of stain can reach 65 ⁇ 78%
  • a traditional Chinese medicine composition is further added to the mask, which is formed by combining a certain amount of Chinese medicinal materials such as hibiscus, grass stone, peony root, licorice and white peony according to a certain quality.
  • Chinese medicinal materials such as hibiscus, grass stone, peony root, licorice and white peony according to a certain quality.
  • Hibiscus contains a variety of trace elements, which make the mask more abundant trace elements from different sources. These trace elements from different sources work synergistically to accelerate the repair of damaged cells, improve the body immunity and resist the external environment. intrusion.
  • a vegetable-derived vitamin is further added to the mask by adding a traditional Chinese medicine composition obtained by mixing and extracting hibiscus, grass stone, peony root, licorice, and white peony into the mask.
  • a traditional Chinese medicine composition obtained by mixing and extracting hibiscus, grass stone, peony root, licorice, and white peony into the mask.
  • flavonoid active compounds, mucilage, phenols, crude protein, amino acids, organic acids, peony, glycyrrhizic acid and other rich active substances not only can further enhance antioxidant, antibacterial and antibacterial effects, but also supplement skin nutrition Revitalizes skin, whitens and diminishes skin spots. With this preferred solution, the time to effect can be shortened.
  • the mask prepared by the preferred method can effectively treat acne and fade spots after continuous use for 2 weeks, and the effective rate of acne can reach 95%, and the cure rate can reach 78-89%.
  • the efficiency can reach 94%, and the stain cure rate can reach 80 ⁇ 90%.
  • the mask provided by the invention has good safety and no toxic and side effects.
  • the prepared mask can be used as it is, or it can be used by infiltrating a special non-woven fabric for masks. Generally, each non-woven fabric is infiltrated with 50 ml of a mask liquid.
  • Example 1 The present invention will be further described in detail below with reference to the embodiments.
  • Example 1
  • each component according to the following formula: 3 parts of trace element composition, 5 parts of collagen, 35 parts of hydrogen-rich oxygen-enriched water, 0.5 parts of hyaluronic acid, 5 parts of superoxide dismutase, hydroxyethyl cellulose 4 Parts; propylene glycol 10 parts; preservative DMDM hydantoin 0.05 parts.
  • the trace element composition is a combination of zinc gluconate and sodium selenite according to a mass ratio of 10:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water in a mass ratio of 1:3, hydrogen-rich water.
  • the hydrogen concentration was 1.2 ppm, and the oxygen-enriched water contained a dissolved oxygen concentration of 50 ppm.
  • the specific activity of the superoxide dismutase used was 2000 IU/mg.
  • the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 5:1
  • the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water
  • the hydrogen concentration was 0.9 ppm
  • the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm.
  • the specific activity of the superoxide dismutase used was 1000 IU/mg.
  • step 2 (3) Pour hydrogen-rich oxygen-rich water, hydroxyethyl cellulose, propylene glycol, preservative, hyaluronic acid, superoxide dismutase into another sterilized container, stir until the components are completely dissolved and mixed, The substance in step 2 is poured into it and continuously stirred until the components are completely dissolved, and finally sterilized and filled.
  • the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 7:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water in a mass ratio of 1:2, hydrogen-rich water.
  • the hydrogen concentration is 1.0 ppm, and the oxygen-enriched water has a dissolved oxygen concentration of 30 ppm.
  • the specific activity of the superoxide dismutase used was 1500 IU/mg.
  • step 2 (3) Pour hydrogen-rich oxygen-rich water, hydroxyethyl cellulose, propylene glycol, preservative, hyaluronic acid, superoxide dismutase into another sterilized container, stir until the components are completely dissolved and mixed, The substance in step 2 is poured into it and continuously stirred until the components are completely dissolved, and finally sterilized and filled.
  • the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 5:1
  • the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water
  • the hydrogen concentration was 0.9 ppm
  • the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm.
  • the specific activity of the superoxide dismutase used is lOOOIU/mgo
  • the traditional Chinese medicine composition used was prepared as follows:
  • the trace element composition is a combination of zinc gluconate and sodium selenite according to a mass ratio of 5:1
  • the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water
  • the hydrogen concentration was 0.9 ppm
  • the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm.
  • the specific activity of the superoxide dismutase used is 1000 IU/mgo (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
  • the traditional Chinese medicine composition used was prepared as follows:
  • the traditional Chinese medicine composition used was prepared as follows:
  • the face often has acne and the face is dull.
  • the acne disappears and the skin is more moist and tender.
  • White After using the product of the first embodiment of the invention for 3 weeks, the acne disappears and the skin is more moist and tender.

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Abstract

A facial mask used for treatment of an acne hyperpigmentation spot and for whitening. The formula of the facial mask comprises constituents of the following parts by mass: 1 to 3 parts of a trace element composition, 3 to 5 parts of collagen, 25 to 35 parts of hydrogen-rich and oxygen-rich water, 0.1 to 0.5 parts of hyaluronic acid, 1 to 5 parts of a superoxide dismutase, 4 to 6 parts of hydroxyethyl cellulose, 10 to 20 parts of propanediol, and 0.05 to 0.1 parts of a preservative, where the trace element composition is one or two between zinc gluconate and sodium selenite, and the hydrogen-rich and oxygen-rich water is a mixture of hydrogen-rich water and oxygen-rich water.

Description

一种用于治疗青春痘色素沉斑和美白的面膜 技术领域  Mask for treating acne pigmentation and whitening
本发明涉及具有治疗青春痘、 淡化色素沉斑、 具有美白作用的面膜。  The invention relates to a mask having the functions of treating acne, diminishing pigmentation spots and having whitening effect.
背景技术 Background technique
青春痘是一种皮肤病, 又称粉刺、 暗疮、 痤疮或面疮, 是处于青春期发育期、 油性 皮肤严重、 喜吃脂肪和糖类食品辛辣刺激食物因为熬夜或工作性质等因素造成的一种常 见皮肤病。 患者因皮脂腺分泌过盛, 大量的角质层脱落, 与油脂尘垢混合后, 使毛孔堵 塞, 进而引发毛囊红肿发炎。 严重时还会造成色素细胞增生, 留下难以消除的色素沉着 斑等, 对患者容貌产生影响。 目前, 市场上治疗青春痘及青春痘造成的色素沉斑的化妆 品大多通过添加化学杀菌剂、 激素等来发挥作用, 虽然这些组分能够在短时间内杀菌或 消除炎症, 但对皮肤刺激性大, 长期使用会增加患者的皮肤负担, 甚至还会进一步引起 皮肤红肿、 化脓或疼痛, 有的还会激发色素细胞的进一步增生, 加重色素沉斑。 如何研 制一种更为安全、 温和、 有效的治疗青春痘及淡化色素沉斑的护肤品已成为本领域亟需 取得突破的课题之一。  Acne is a skin disease, also known as acne, acne, hemorrhoids or facial sores. It is a kind of puberty development, oily skin, eating fat and sugary foods, spicy food, because of staying up late or working nature. Common skin diseases. The patient has excessive secretion of sebaceous glands, and a large amount of stratum corneum is detached. When mixed with grease and dirt, the pores are blocked, which causes redness and inflammation of the hair follicle. In severe cases, it also causes pigment cells to proliferate, leaving pigmentation spots that are difficult to eliminate, and affecting the appearance of patients. At present, cosmetics for treating pigmentation caused by acne and acne are mostly used by adding chemical fungicides, hormones, etc., although these components can sterilize or eliminate inflammation in a short time, but are highly irritating to the skin. Long-term use will increase the patient's skin burden, and may even cause skin redness, suppuration or pain, and some will stimulate the further proliferation of pigment cells and aggravate pigmentation spots. How to develop a safer, gentler and more effective skin care product for treating acne and diminishing pigmentation has become one of the urgent breakthroughs in the field.
发明内容 Summary of the invention
为弥补现有技术的不足, 本发明的目的在于提供一种刺激性小、 无毒副作用、 可有 效祛除青春痘及淡化色素沉斑, 同时起到美白作用的面膜。  In order to make up for the deficiencies of the prior art, the object of the present invention is to provide a mask which is less irritating, has no toxic side effects, can effectively eliminate acne and dilute pigmentation spots, and at the same time functions as a whitening effect.
本发明解决其技术问题, 所采用的技术方案如下:  The invention solves the technical problems thereof, and the technical solutions adopted are as follows:
一种用于治疗青春痘色素沉斑和美白的面膜,面膜配方中包含如下质量份的各组份: 微量元素组合物 1~3份、胶原蛋白 3~5份、 富氢富氧水 25~35份、 玻尿酸 0.1~0.5份、超 氧化物歧化酶 1~5份、 羟乙基纤维素 4~6份、 丙二醇 10~20份、 防腐剂 0.05~0.1份; 其 中, 所述微量元素组合物为葡萄糖酸锌、 亚硒酸钠中的一种或两种, 富氢富氧水为富氢 水和富氧水的混合物。 本发明所用的超氧化物歧化酶其比活力为 1000~2000IU/mg。  A mask for treating acne pigmentation and whitening, the mask formula contains the following components: 1-3 parts of trace element composition, 3~5 parts of collagen, hydrogen-rich oxygen-rich water 25~ 35 parts, 0.1-0.5 parts of hyaluronic acid, 1~5 parts of superoxide dismutase, 4-6 parts of hydroxyethyl cellulose, 10-20 parts of propylene glycol, 0.05-0.1 parts of preservative; wherein the trace element composition It is one or both of zinc gluconate and sodium selenite, and the hydrogen-rich oxygen-enriched water is a mixture of hydrogen-rich water and oxygen-enriched water. The superoxide dismutase used in the present invention has a specific activity of 1000 to 2000 IU/mg.
所述防腐剂并无特别限制,可选用化妆品领域常用的防腐剂,例如可选择 DMDM乙 内酰脲、 羟苯甲酯等。  The preservative is not particularly limited, and a preservative commonly used in the cosmetic field may be selected, for example, DMDM hydantoin, methylparaben or the like may be selected.
所述微量元素组合物为葡萄糖酸锌和亚硒酸钠按照质量比 (5~10): 1组合而成。 所述富氢富氧水为质量比 1: ( 1-3 ) 的富氢水和富氧水的组合。  The trace element composition is a combination of zinc gluconate and sodium selenite according to a mass ratio (5-10):1. The hydrogen-rich oxygen-enriched water is a combination of hydrogen-rich water and oxygen-enriched water having a mass ratio of 1: (1-3).
所述富氢水其含氢 (以氢气分子计) 浓度为 0.9~1.2ppm, 所述富氧水其含有的溶解 氧浓度为 20~50ppm。 优选的, 面膜配方中还含有中药组合物 5~10质量份, 所述中药组合物由如下药材配 方的各组分提取制得: 木槿花 1~5质量份、 草石蚕 2~5质量份、 牡丹根皮 1~3质量份、 甘草 2~6质量份、 白茯苓 1~4质量份。 The hydrogen-rich water has a hydrogen (in terms of hydrogen molecules) concentration of 0.9 to 1.2 ppm, and the oxygen-enriched water contains a dissolved oxygen concentration of 20 to 50 ppm. Preferably, the mask formulation further comprises 5 to 10 parts by mass of the traditional Chinese medicine composition, and the traditional Chinese medicine composition is obtained by extracting the components of the following medicinal material formula: 1 to 5 parts by mass of hibiscus, 2 to 5 parts by mass of sarcophagus 1 to 3 parts by mass of peony bark, 2 to 6 parts by mass of licorice, and 1 to 4 parts by mass of white peony.
进一步优选的, 所述药材配方为: 木槿花 3质量份、 草石蚕 4质量份、 牡丹根皮 2 质量份、 甘草 4质量份、 白茯苓 2质量份。  Further preferably, the medicinal material is formulated as: 3 parts by mass of hibiscus, 4 parts by mass of sarcophagus, 2 parts by mass of peony root, 4 parts by mass of licorice, and 2 parts by mass of peony.
优选的, 所述中药组合物按照如下步骤的提取工艺制得:  Preferably, the traditional Chinese medicine composition is prepared according to the following extraction process:
1 )按药材配方称取各味药材, 将草石蚕、 牡丹根皮、 白茯苓粉碎后与木槿花、 甘草 混合, 加人去离子水室温浸泡 4~8小时, 所加水量为药材总质量的 4~6倍;  1) Weigh each medicinal material according to the medicinal material formula, smash the grass stone silkworm, peony root bark and white peony, mix it with hibiscus flower and licorice, add human deionized water for 4~8 hours at room temperature, and add water to the total quality of medicinal materials. 4 to 6 times;
2) 之后在 50~60 °C下加热煎煮 3~5小时, 将所得提取液进行过滤, 所得滤液即为中 药组合物。  2) After heating and boiling at 50 to 60 ° C for 3 to 5 hours, the obtained extract is filtered, and the obtained filtrate is a traditional Chinese medicine composition.
下面对本发明的技术方案中所用的几种组分进行介绍:  The following describes the components used in the technical solution of the present invention:
胶原蛋白: 胶原蛋白 (collagen) 是一种生物性高分子物质, 是一种白色、 不透明、 无支链的纤维性蛋白质。 它可以补充皮肤各层所需的营养, 使皮肤中胶原活性增强, 对 滋润皮肤, 延缓衰老、 美容、 消皱、 养发等有一定功效。  Collagen: Collagen (collagen) is a biological polymer substance, a white, opaque, unbranched fibrous protein. It can replenish the nutrients needed in all layers of the skin, enhance the collagen activity in the skin, and have certain effects on moisturizing the skin, delaying aging, beauty, wrinkle and hair growth.
富氢水: 又称水素水 (Hydrogen Water) , 是日语的音译, 氢气本身就是一种最佳天 然抗氧化剂, 所以加入氢气的水具有很强的还原功能。 可以中和身体血液和细胞里的活 性氧(自由基)。 现代医学认为活性氢可以有效去除体内自由基, 富氢水具有超过维生素 C、胡萝卜、卵磷脂等所有人类已知抗氧化物的抗氧化性,对过敏性皮炎、便秘、高血压、 糖尿病、 癌症等由自由基引起的各类症状都有强大的防治作用。 富氢水能够很好的促进 新陈代谢, 使每个细胞都能自动保持健康的状态, 去除体锈, 延缓衰老。 富氢水其制取 方法已是一种较为成熟的技术, 如公开号为 CN102408147A的中国专利申请介绍了富氢 水的一种制取方法。  Hydrogen-rich water: Also known as Hydrogen Water, it is a Japanese transliteration. Hydrogen itself is one of the best natural antioxidants, so the water added with hydrogen has a strong reducing function. It can neutralize active oxygen (free radicals) in the body's blood and cells. Modern medicine believes that active hydrogen can effectively remove free radicals in the body. Hydrogen-rich water has more antioxidant properties than all known human antioxidants such as vitamin C, carrots, lecithin, etc., for allergic dermatitis, constipation, hypertension, diabetes, cancer. All kinds of symptoms caused by free radicals have a strong preventive effect. Hydrogen-rich water promotes metabolism and allows each cell to maintain a healthy state, remove body rust and delay aging. The preparation method of hydrogen-rich water has been a relatively mature technology, and a method for preparing hydrogen-rich water is described in Chinese Patent Application Publication No. CN102408147A.
富氧水: 是指使溶于水中的溶解氧浓度而比一般的水高的含有更多氧的水。 将这种 含有高浓度溶解氧的水直接供给到皮肤上, 能够促进皮肤细胞的呼吸病活化细胞, 提高 保湿能力, 延缓衰老, 促进皮肤的更新, 从而促进排出皮肤中生产的黑色素, 从而可以 显示美白效果。 富氧水是一种天然的抗微生物防腐剂与氧增加剂, 可促进皮肤的新陈代 谢, 促进整体皮肤的健康。 富氧水其制取方法已是一种成熟的技术, 如公开号为 CN1200355A的中国专利申请以及公开号为 CN102641223A的中国专利申请中均介绍了 富氧水的制取方法。  Oxygen-enriched water: refers to water containing more oxygen in which the dissolved oxygen concentration in water is higher than that of ordinary water. By directly supplying the water containing a high concentration of dissolved oxygen to the skin, it can promote the respiratory cells of the skin cells to activate the cells, improve the moisturizing ability, delay the aging, promote the renewal of the skin, and thereby promote the discharge of melanin produced in the skin, thereby displaying Whitening effect. Oxygen-enriched water is a natural anti-microbial preservative and oxygen booster that promotes skin metabolism and promotes overall skin health. The preparation method of the oxygen-enriched water is a well-established technique, and the preparation method of the oxygen-enriched water is described in the Chinese Patent Application Publication No. CN1200355A and the Chinese Patent Application Publication No. WO102641223A.
玻尿酸: 玻尿酸不仅有保持皮肤弹性的功能, 还能锁住大量水分子, 对组织具有保 湿润滑作用, 使肌肤饱满年轻有弹性, 但随着年龄的增长, 玻尿酸流失的速度比生长速 度快时, 肌肤也将渐渐变得缺乏水分, 失去光泽弹性, 长久下来便出现皱纹等老化现象。 Hyaluronic acid: Hyaluronic acid not only has the function of maintaining skin elasticity, but also locks a lot of water molecules, which protects the tissues. Wet lubrication can make the skin full and young and elastic. However, as the age of hyaluronic acid loses faster than the growth rate, the skin will gradually become deficient in moisture, lose luster elasticity, and wrinkles and other aging phenomena will appear in the long run.
超氧化物歧化酶(SOD): SOD 是很强的氧化还原剂, 能与体内的氧自由基发生还 原反应, 从而使人体细胞修复和基因组织不受损害; 对人体不断地补充 SOD具有抗衰老 的效果, 超氧化物歧化酶 (SOD) 为自由基清除剂, 能清除自由基 02- (超氧阴离子自 由基), 而 02-具有细胞毒性, 可使脂质过氧化, 损伤细胞膜, 引起炎症, 肿瘤和自身免 疫性疾病, 并可能促使机体衰老。 SOD是强力自由基清除剂, 可以抑制色素细胞沉积, 具有抗衰老、 免疫调节和抗辐射作用。  Superoxide dismutase (SOD): SOD is a strong redox agent that can react with oxygen free radicals in the body, so that human cell repair and gene organization are not damaged. Anti-aging is constantly supplemented by SOD. The effect of superoxide dismutase (SOD) is a free radical scavenger that scavenges free radicals 02- (superoxide anion radicals), while 02- is cytotoxic, can cause lipid peroxidation, damage cell membranes, cause inflammation , tumors and autoimmune diseases, and may cause the body to age. SOD is a powerful free radical scavenger that inhibits pigment cell deposition and has anti-aging, immune regulation and anti-radiation effects.
木槿花: 含有丰富的维生素 C、 铁、 钙、 锌、 硒等微量元素, 并含有黄酮类活性化 合物及粘液质。 木槿花提取液具有保湿、 抗氧化、 清除自由基的功能, 能抑制金黄色葡 萄球菌和伤寒杆菌。  Hibiscus: It is rich in vitamin C, iron, calcium, zinc, selenium and other trace elements, and contains flavonoid active compounds and mucus. The hibiscus extract has the functions of moisturizing, anti-oxidation and scavenging free radicals, and can inhibit Staphylococcus aureus and Salmonella typhi.
草石蚕: 又名银条, 是我国河南省偃师市的特产, 形状、 味道与绿豆芽相似。 草石 蚕富含糖类、 酚类、 维生素 c、 粗蛋白、 氨基酸、 有机酸等物质, 对软化血管、 降低血 月旨、 改善血液循环具有独特的疗效。  Grass stone silkworm: Also known as silver bar, it is a specialty of Yanshi City, Henan Province, China. Its shape and taste are similar to those of green bean sprouts. Grass stone Silkworm is rich in sugar, phenols, vitamin c, crude protein, amino acids, organic acids, etc. It has a unique effect on softening blood vessels, lowering blood and improving blood circulation.
牡丹根皮: 为毛茛科植物牡丹干燥根皮。 所含牡丹酚及其以外的糖苷类成分均有抗 炎作用; 牡丹皮的甲醇提取物有抑制血小板作用; 牡丹酚有镇静、 降温、 解热、 镇痛、 解痉等中枢抑制作用及抗动脉粥样硬化、 利尿、 抗溃疡等作用。 牡丹根皮提取成分有抗 菌消炎除痘和美白等作用。  Peony root bark: dry root bark of peony family of Ranunculaceae. The peony phenol and other glycoside components have anti-inflammatory effects; the methanol extract of peony bark has the effect of inhibiting platelets; peony phenol has central inhibition of sedation, cooling, antipyretic, analgesic, antispasmodic and anti-arterial Atherosclerosis, diuretic, anti-ulcer and so on. The extract of peony root bark has anti-bacterial, anti-inflammatory, acne and whitening effects.
甘草: 味甘、 平。 甘草还有抗炎, 抗过敏作用, 能保护发炎的咽喉和气管粘膜。 甘 草浸膏和甘草酸对某些毒物有类似葡萄糖醛酸的解毒作用。甘草能清热解毒, 润肺止咳, 调和诸药性; 具有抗炎、 抗病毒, 和保肝解毒及增强免疫功能等作用。 缓解药物毒性、 烈性。 甘草的黄酮具有消炎、 解痉和抗酸作用; 解毒作用的有效成份为甘草甜素, 解毒 机制为甘草甜素对毒物有吸附作用。  Licorice: Sweet and flat. Licorice also has anti-inflammatory and anti-allergic effects, which can protect the inflamed throat and tracheal mucosa. Licorice extract and glycyrrhizic acid have a detoxifying effect similar to glucuronic acid to certain poisons. Licorice can clear away heat and detoxify, moisten the lungs and relieve cough, and reconcile various medicinal properties; it has anti-inflammatory, anti-viral, liver-protecting and detoxifying functions and enhances immune function. Relieve the toxicity and potency of the drug. The flavonoids of licorice have anti-inflammatory, antispasmodic and anti-acid effects; the effective component of detoxification is glycyrrhizin, and the detoxification mechanism is the adsorption of glycyrrhizin on poisons.
白茯苓: 具有美白抗炎, 防护紫外线损伤, 促进皮肤代谢的作用。  White peony: It has whitening and anti-inflammatory properties, protects against UV damage and promotes skin metabolism.
本发明所采用的技术方案具有如下有益效果:  The technical solution adopted by the invention has the following beneficial effects:
( 1 )本发明一种实施方案中, 在面膜中添加微量元素组合物、 胶原蛋白、 富氢富氧 水、 玻尿酸、 超氧化物歧化酶, 这些组分按照特定的质量配伍, 对青春痘具有良好的治 疗效果, 对沉着色斑具有淡化功效, 同时起到美白作用。 由葡萄糖酸锌、 亚硒酸钠组合 形成的微量元素组合物, 可为皮肤补充锌、 硒。 锌具有协调免疫反应的作用, 锌参与碳 酸酐酶、 碱性磷酸酶、 DNA聚合酶等多种酶的合成, 增加创伤组织的修复。 硒是功效卓 著和全面的抗氧化剂, 在大幅延迟细胞衰老的同时还同步有力阻止胶原蛋白变性, 亦即 增加胶原蛋白合成量又减少其流失量。 目前的研究证明, 硒具有抗氧化作用, 清除自由 基保护细胞膜结构合功能, 修复分子损伤部位; 硒可促进体内多种代谢活动, 硒是肌肉 的正常成分, 是谷胱甘肽过氧化酶的必需成分呢, 硒在人体内有拮抗和降低多种重金属 毒性的作用, 硒能刺激免疫球蛋白和抗体的产生, 提高肌体免疫功能。 富氢水和富氧水 混合形成的富氢富氧水, 含有丰富的活性氢和溶解氧, 促进新陈代谢, 使每个细胞都能 自动保持健康的状态, 有效清除体内自由基, 促进皮肤细胞的呼吸并活化细胞, 提高保 湿能力, 促进皮肤的更新及排出皮肤中产生的黑色素。 配方中同时搭配胶原蛋白、 玻尿 酸及超氧化物歧化酶, 为肌肤补充水分营养及胶原蛋白成分, 同时 SOD作为强力自由基 清除剂, 还可抑制色素细胞沉积。 在这种方案, 微量元素、 胶原蛋白、 富氢富氧水、 玻 尿酸和超氧化物歧化酶合理搭配应用, 能提高机体免疫力、 修复创伤、 活化细胞, 达到 祛痘的目的, 同时还可促进细胞新陈代谢及抑制黑色素沉积, 实现淡化色素沉斑的效果。 实践证明, 连续使用 3周后青春痘有效率就可达到 91 %, 治愈率可达到 70~80%, 色斑 有效率可达到 88%, 色斑治愈率可达到 65~78%; (1) In one embodiment of the present invention, a trace element composition, collagen, hydrogen-rich oxygen-enriched water, hyaluronic acid, superoxide dismutase is added to the mask, and these components are compatible according to a specific quality, and have acne Good therapeutic effect, it has a lightening effect on the sun stains, and at the same time plays a whitening effect. A trace element composition formed by a combination of zinc gluconate and sodium selenite, which can supplement zinc and selenium to the skin. Zinc has a role in coordinating immune responses. Zinc is involved in the synthesis of various enzymes such as carbonic anhydrase, alkaline phosphatase, and DNA polymerase, and increases the repair of wound tissue. Selenium is effective The comprehensive antioxidants, while significantly delaying cell aging, simultaneously prevent the denaturation of collagen, which increases the amount of collagen synthesis and reduces its loss. The current research proves that selenium has anti-oxidation effect, scavenging free radicals to protect cell membrane structure and function, and repairing molecular damage sites; selenium can promote various metabolic activities in the body. Selenium is a normal component of muscle and is glutathione peroxidase. Essential ingredients, selenium has the effect of antagonizing and reducing the toxicity of various heavy metals in the human body. Selenium can stimulate the production of immunoglobulins and antibodies and improve the immune function of the body. The hydrogen-rich and oxygen-rich water formed by the mixture of hydrogen-rich water and oxygen-enriched water is rich in active hydrogen and dissolved oxygen, promotes metabolism, enables each cell to maintain a healthy state automatically, effectively removes free radicals in the body, and promotes skin cells. Breathe and activate cells, improve moisturizing ability, promote skin renewal and discharge melanin produced in the skin. Formulated with collagen, hyaluronic acid and superoxide dismutase to replenish moisture and collagen to the skin. SOD acts as a powerful free radical scavenger and inhibits pigment cell deposition. In this scheme, the combination of trace elements, collagen, hydrogen-rich oxygen-enriched water, hyaluronic acid and superoxide dismutase can improve the body's immunity, repair wounds, activate cells, achieve acne, and promote Cell metabolism and inhibition of melanin deposition, to achieve the effect of lightening pigmentation spots. Practice has proved that after 3 weeks of continuous use, the efficiency of acne can reach 91%, the cure rate can reach 70-80%, the effective rate of stain can reach 88%, and the cure rate of stain can reach 65~78%;
( 2)本发明的一种优选方案中, 在面膜中进一步添加中药组合物, 其由木槿花、 草 石蚕、 牡丹根皮、 甘草、 白茯苓这几种中药材按照一定质量配伍形成, 可为面膜补充天 然有效成分, 提升祛痘及淡化沉斑, 同时还有美白效果。 木槿花中含有多种微量元素, 使面膜中具有不同来源的更为丰富的微量元素, 这些不同来源的微量元素协同作用, 加 速对损伤细胞的修复, 更好的提升机体免疫力、 抵抗外部环境侵扰。 通过在面膜中添加 由木槿花、 草石蚕、 牡丹根皮、 甘草、 白茯苓混合提取制得的中药组合物, 还进一步为 面膜补充了植物来源的维生素。、 黄酮类活性化合物、 粘液质、 酚类、 粗蛋白、 氨基酸、 有机酸、 牡丹酚、 甘草酸等丰富的活性物质, 不仅可进一步提升抗氧化作用、 抑菌抗菌 作用, 而且还可补充肌肤营养、 活化肌肤、 美白淡化肌肤色斑。 采用这种优选方案, 可 以縮短显效时间。 实践证明, 该优选方案制备的面膜, 使用者连续使用 2周后, 就可有 效治疗青春痘、 淡化色斑, 青春痘有效率可达到 95%, 治愈率可达到 78~89%, 色斑有 效率可达到 94%, 色斑治愈率可达到 80~90%。  (2) In a preferred embodiment of the present invention, a traditional Chinese medicine composition is further added to the mask, which is formed by combining a certain amount of Chinese medicinal materials such as hibiscus, grass stone, peony root, licorice and white peony according to a certain quality. Adds natural active ingredients to the mask to enhance acne and fade spots, as well as whitening effects. Hibiscus contains a variety of trace elements, which make the mask more abundant trace elements from different sources. These trace elements from different sources work synergistically to accelerate the repair of damaged cells, improve the body immunity and resist the external environment. intrusion. A vegetable-derived vitamin is further added to the mask by adding a traditional Chinese medicine composition obtained by mixing and extracting hibiscus, grass stone, peony root, licorice, and white peony into the mask. , flavonoid active compounds, mucilage, phenols, crude protein, amino acids, organic acids, peony, glycyrrhizic acid and other rich active substances, not only can further enhance antioxidant, antibacterial and antibacterial effects, but also supplement skin nutrition Revitalizes skin, whitens and diminishes skin spots. With this preferred solution, the time to effect can be shortened. Practice has proved that the mask prepared by the preferred method can effectively treat acne and fade spots after continuous use for 2 weeks, and the effective rate of acne can reach 95%, and the cure rate can reach 78-89%. The efficiency can reach 94%, and the stain cure rate can reach 80~90%.
( 3 )本发明提供的面膜安全性好, 无毒副作用。 所制备的面膜可直接涂抹使用, 也 可通过浸润面膜专用无纺布来使用, 一般每张无纺布用 50ml面膜液浸润。  (3) The mask provided by the invention has good safety and no toxic and side effects. The prepared mask can be used as it is, or it can be used by infiltrating a special non-woven fabric for masks. Generally, each non-woven fabric is infiltrated with 50 ml of a mask liquid.
具体实施方式 detailed description
下面结合实施例对本发明作进一步详细说明。 实施例 1 : The present invention will be further described in detail below with reference to the embodiments. Example 1:
一种用于治疗青春痘色素沉斑和美白的面膜  A mask for treating acne pigmentation and whitening
( 1 ) 按照如下配方称取各组份: 微量元素组合物 3份、 胶原蛋白 5份、 富氢富氧水 35份、 玻尿酸 0.5份、 超氧化物歧化酶 5份, 羟乙基纤维素 4份; 丙二醇 10份; 防腐剂 DMDM 乙内酰脲 0.05份。 其中, 微量元素组合物为葡萄糖酸锌、 亚硒酸钠按照质量比 10: 1组合而成, 富氢富氧水为富氢水和富氧水按照质量比 1: 3的混合物, 富氢水其含 氢浓度为 1.2ppm, 富氧水其含有的溶解氧浓度为 50ppm。 所用超氧化物歧化酶的比活力 为 2000IU/mg。  (1) Weigh each component according to the following formula: 3 parts of trace element composition, 5 parts of collagen, 35 parts of hydrogen-rich oxygen-enriched water, 0.5 parts of hyaluronic acid, 5 parts of superoxide dismutase, hydroxyethyl cellulose 4 Parts; propylene glycol 10 parts; preservative DMDM hydantoin 0.05 parts. The trace element composition is a combination of zinc gluconate and sodium selenite according to a mass ratio of 10:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water in a mass ratio of 1:3, hydrogen-rich water. The hydrogen concentration was 1.2 ppm, and the oxygen-enriched water contained a dissolved oxygen concentration of 50 ppm. The specific activity of the superoxide dismutase used was 2000 IU/mg.
(2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用; (3)将富氢富氧水、 羟乙基纤维素、 丙二醇、 防腐剂、 玻尿酸、 超氧化物歧化酶倒 入另一已消毒的容器中, 搅拌至各组份完全溶解并混匀, 将步骤 2中的物质倒入其中, 并不断搅拌至各组分均完全溶解, 最后进行灭菌灌装。  (2) Pour the trace element composition and collagen into a cleaned and sterilized container for sealing; (3) Hydrogen-rich oxygen-rich water, hydroxyethyl cellulose, propylene glycol, preservative, hyaluronic acid, superoxide Pour dismutase into another sterilized container, stir until the components are completely dissolved and mixed, pour the substance in step 2 into it, and continue to stir until the components are completely dissolved, and finally sterilize Installed.
实施例 2:  Example 2:
一种用于治疗青春痘色素沉斑和美白的面膜  A mask for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 1份、 胶原蛋白 3份、 富氢富氧水 (1) Weigh each component according to the following formula: Trace element composition 1 part, collagen 3 parts, hydrogen-rich oxygen-enriched water
25份、 玻尿酸 0.1份、 超氧化物歧化酶 1份, 羟乙基纤维素 6份; 丙二醇 20份; 防腐剂 0.1份。 其中, 微量元素组合物为葡萄糖酸锌、 亚硒酸钠按照质量比 5: 1组合而成, 富 氢富氧水为富氢水和富氧水按照质量比 1:1的混合物, 富氢水其含氢浓度为 0.9ppm, 富 氧水其含有的溶解氧浓度为 20ppm。 所用超氧化物歧化酶的比活力为 1000IU/mg。 25 parts, 0.1 parts of hyaluronic acid, 1 part of superoxide dismutase, 6 parts of hydroxyethyl cellulose; 20 parts of propylene glycol; 0.1 part of preservative. Wherein, the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 5:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water The hydrogen concentration was 0.9 ppm, and the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm. The specific activity of the superoxide dismutase used was 1000 IU/mg.
(2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用; (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
(3)将富氢富氧水、 羟乙基纤维素、 丙二醇、 防腐剂、 玻尿酸、 超氧化物歧化酶倒 入另一已消毒的容器中, 搅拌至各组份完全溶解并混匀, 将步骤 2中的物质倒入其中, 并不断搅拌至各组分均完全溶解, 最后进行灭菌灌装。 (3) Pour hydrogen-rich oxygen-rich water, hydroxyethyl cellulose, propylene glycol, preservative, hyaluronic acid, superoxide dismutase into another sterilized container, stir until the components are completely dissolved and mixed, The substance in step 2 is poured into it and continuously stirred until the components are completely dissolved, and finally sterilized and filled.
实施例 3:  Example 3:
一种用于治疗青春痘色素沉斑和美白的面膜  A mask for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 2份、 胶原蛋白 4份、 富氢富氧水 30份、 玻尿酸 0.3份、 超氧化物歧化酶 3份, 羟乙基纤维素 5份; 丙二醇 15份; 防腐剂 0.07份。 其中, 微量元素组合物为葡萄糖酸锌、 亚硒酸钠按照质量比 7: 1组合而成, 富 氢富氧水为富氢水和富氧水按照质量比 1:2的混合物, 富氢水其含氢浓度为 l.Oppm, 富 氧水其溶解氧浓度为 30 ppm。 所用超氧化物歧化酶的比活力为 1500IU/mg。 (2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用;(1) Weigh each component according to the following formula: 2 parts of trace element composition, 4 parts of collagen, 30 parts of hydrogen-rich oxygen-enriched water, 0.3 parts of hyaluronic acid, 3 parts of superoxide dismutase, hydroxyethyl cellulose 5 Parts; 15 parts of propylene glycol; 0.07 parts of preservative. Wherein, the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 7:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water in a mass ratio of 1:2, hydrogen-rich water. The hydrogen concentration is 1.0 ppm, and the oxygen-enriched water has a dissolved oxygen concentration of 30 ppm. The specific activity of the superoxide dismutase used was 1500 IU/mg. (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
(3)将富氢富氧水、 羟乙基纤维素、 丙二醇、 防腐剂、 玻尿酸、 超氧化物歧化酶倒 入另一已消毒的容器中, 搅拌至各组份完全溶解并混匀, 将步骤 2中的物质倒入其中, 并不断搅拌至各组分均完全溶解, 最后进行灭菌灌装。 (3) Pour hydrogen-rich oxygen-rich water, hydroxyethyl cellulose, propylene glycol, preservative, hyaluronic acid, superoxide dismutase into another sterilized container, stir until the components are completely dissolved and mixed, The substance in step 2 is poured into it and continuously stirred until the components are completely dissolved, and finally sterilized and filled.
实施例 4:  Example 4:
一种用于治疗青春痘色素沉斑和美白的面膜  A mask for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 1份、 胶原蛋白 3份、 富氢富氧水 25份、 玻尿酸 0.1份、 超氧化物歧化酶 1份, 羟乙基纤维素 4份; 丙二醇 10份; 防腐剂 0.05份、 中药组合物 5份。 其中, 微量元素组合物为葡萄糖酸锌、 亚硒酸钠按照质量比 5: 1组合而成, 富氢富氧水为富氢水和富氧水按照质量比 1:1的混合物, 富氢水其含氢 浓度为 0.9ppm, 富氧水其含有的溶解氧浓度为 20ppm。 所用超氧化物歧化酶的比活力为 lOOOIU/mgo  (1) Weigh each component according to the following formula: 1 part of trace element composition, 3 parts of collagen, 25 parts of hydrogen-rich oxygen-enriched water, 0.1 part of hyaluronic acid, 1 part of superoxide dismutase, hydroxyethyl cellulose 4 Parts; 10 parts of propylene glycol; 0.05 parts of preservative, 5 parts of traditional Chinese medicine composition. Wherein, the trace element composition is composed of zinc gluconate and sodium selenite according to a mass ratio of 5:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water The hydrogen concentration was 0.9 ppm, and the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm. The specific activity of the superoxide dismutase used is lOOOIU/mgo
(2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用; (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
(3) 将富氢富氧水、 羟乙基纤维素、 丙二醇、 防腐剂、 玻尿酸、 超氧化物歧化酶、 中药组合物倒入另一已消毒的容器中, 搅拌至各组份完全溶解并混匀, 将步骤 2中的物 质倒入其中, 并不断搅拌至各组分均完全溶解, 最后进行灭菌灌装。 (3) Pour hydrogen-rich oxygen-enriched water, hydroxyethyl cellulose, propylene glycol, preservative, hyaluronic acid, superoxide dismutase, and traditional Chinese medicine into another sterilized container, stir until the components are completely dissolved. Mix well, pour the substance in step 2 into it, and continue to stir until the components are completely dissolved, and finally sterilize and fill.
所用的中药组合物按照如下步骤制备:  The traditional Chinese medicine composition used was prepared as follows:
a: 按照如下药材配方称取各组分: 木槿花 1质量份、 草石蚕 2质量份、 牡丹根皮 1 质量份、 甘草 2质量份、 白茯苓 1质量份;  a: Weigh each component according to the following medicinal formula: 1 part by mass of hibiscus, 2 parts by mass of sarcophagus, 1 part by mass of peony root, 2 parts by weight of licorice, and 1 part by mass of peony;
b: 将草石蚕、 牡丹根、 白茯苓粉碎后与木槿花、 甘草混合, 加入去离子水室温浸泡 b: After crushing the grass stone, peony root and white peony, mix it with hibiscus and licorice, add deionized water to soak at room temperature.
4小时, 所加水量为药材总质量的 4倍; 4 hours, the amount of water added is 4 times the total mass of the medicine;
c: 之后在 50~60°C下加热煎煮 3小时, 将所得提取液进行过滤。  c: After heating and boiling at 50 to 60 ° C for 3 hours, the resulting extract was filtered.
实施例 5:  Example 5
一种用于治疗青春痘色素沉斑和美白的面膜  A mask for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 1份、 胶原蛋白 3份、 富氢富氧水 (1) Weigh each component according to the following formula: Trace element composition 1 part, collagen 3 parts, hydrogen-rich oxygen-enriched water
25份、 玻尿酸 0.1份、 超氧化物歧化酶 1份、 羟乙基纤维素 6份; 丙二醇 20份; 防腐剂 0.1份、 中药组合物 8份。其中, 微量元素组合物为葡萄糖酸锌、亚硒酸钠按照质量比 5: 1组合而成, 富氢富氧水为富氢水和富氧水按照质量比 1:1的混合物, 富氢水其含氢浓度 为 0.9ppm, 富氧水其含有的溶解氧浓度为 20ppm。 所用超氧化物歧化酶的比活力为 lOOOIU/mgo (2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用;25 parts, 0.1 parts of hyaluronic acid, 1 part of superoxide dismutase, 6 parts of hydroxyethyl cellulose; 20 parts of propylene glycol; 0.1 part of preservative and 8 parts of traditional Chinese medicine composition. Wherein, the trace element composition is a combination of zinc gluconate and sodium selenite according to a mass ratio of 5:1, and the hydrogen-rich oxygen-rich water is a mixture of hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1:1, hydrogen-rich water The hydrogen concentration was 0.9 ppm, and the oxygen-enriched water contained a dissolved oxygen concentration of 20 ppm. The specific activity of the superoxide dismutase used is 1000 IU/mgo (2) Pour the trace element composition and collagen into a cleaned and sterilized container and set aside;
( 3 ) 将富氢富氧水、 羟乙基纤维素、 丙二醇、 防腐剂、 玻尿酸、 超氧化物歧化酶、 中药组合物倒入另一已消毒的容器中, 搅拌至各组份完全溶解并混匀, 将步骤 2中的物 质倒入其中, 并不断搅拌至各组分均完全溶解, 最后进行灭菌灌装。 (3) Pour hydrogen-rich oxygen-enriched water, hydroxyethyl cellulose, propylene glycol, preservative, hyaluronic acid, superoxide dismutase, and traditional Chinese medicine into another sterilized container, stir until the components are completely dissolved. Mix well, pour the substance in step 2 into it, and continue to stir until the components are completely dissolved, and finally sterilize and fill.
所用的中药组合物按照如下步骤制备:  The traditional Chinese medicine composition used was prepared as follows:
a: 按照如下药材配方称取各组分: 木槿花 5质量份、 草石蚕 5质量份、 牡丹根皮 3 质量份、 甘草 6质量份、 白茯苓 4质量份;  a: Weigh each component according to the following medicinal formula: 5 parts by mass of hibiscus, 5 parts by weight of sarcophagus, 3 parts by mass of peony root, 6 parts by weight of licorice, and 4 parts by mass of peony;
b: 将草石蚕、 牡丹根、 白茯苓粉碎后与木槿花、 甘草混合, 加入去离子水室温浸泡 8小时, 所加水量为药材总质量的 6倍;  b: crushing grass stone, peony root and white peony, mixing with hibiscus and licorice, adding deionized water for 8 hours at room temperature, the added water is 6 times of the total mass of the medicinal material;
c: 之后在 50~60°C下加热煎煮 5小时, 将所得提取液进行过滤。  c: After heating and boiling at 50 to 60 ° C for 5 hours, the resulting extract was filtered.
实施例 6:  Example 6:
一种用于治疗青春痘色素沉斑和美白的面膜  A mask for treating acne pigmentation and whitening
( 1 )按照如下配方称取各组份: 微量元素组合物 2份、 胶原蛋白 4份、 富氢富氧水 30份、 玻尿酸 0.3份、 超氧化物歧化酶 3份、 羟乙基纤维素 5份; 丙二醇 15份; 防腐剂 0.07份、 中药组合物 10份, 其中, 微量元素组合物为葡萄糖酸锌、 亚硒酸钠按照质量比 7: 1组合而成, 富氢富氧水为富氢水和富氧水按照质量比 1:2的混合物, 富氢水其含氢 浓度为 l.Oppm, 富氧水其含有的溶解氧浓度为 30 ppm。所用超氧化物歧化酶的比活力为
Figure imgf000008_0001
(1) Weigh each component according to the following formula: 2 parts of trace element composition, 4 parts of collagen, 30 parts of hydrogen-rich oxygen-enriched water, 0.3 parts of hyaluronic acid, 3 parts of superoxide dismutase, hydroxyethyl cellulose 5 15 parts of propylene glycol; 0.07 parts of preservative and 10 parts of traditional Chinese medicine composition, wherein the trace element composition is composed of zinc gluconate and sodium selenite in a mass ratio of 7:1, and hydrogen-rich oxygen-rich water is hydrogen-rich The water and oxygen-enriched water are in a mixture of mass ratio 1:2, and the hydrogen-rich water has a hydrogen concentration of 1.0 ppm, and the oxygen-enriched water contains a dissolved oxygen concentration of 30 ppm. The specific activity of the superoxide dismutase used is
Figure imgf000008_0001
(2) 将微量元素组合物和胶原蛋白倒入洗净并已消毒的容器中密封, 备用; ( 3 ) 将富氢富氧水、 羟乙基纤维素、 丙二醇、 防腐剂、 玻尿酸、 超氧化物歧化酶、 中药组合物倒入另一已消毒的容器中, 搅拌至各组份完全溶解并混匀, 将步骤 2中的物 质倒入其中, 并不断搅拌至各组分均完全溶解, 最后进行灭菌灌装。  (2) Pour the trace element composition and collagen into a cleaned and sterilized container for sealing; (3) Hydrogen-rich oxygen-rich water, hydroxyethyl cellulose, propylene glycol, preservative, hyaluronic acid, superoxide The disproportionation enzyme and the traditional Chinese medicine composition are poured into another sterilized container, stirred until the components are completely dissolved and mixed, and the substance in the step 2 is poured therein, and continuously stirred until the components are completely dissolved, and finally Sterilize and fill.
所用的中药组合物按照如下步骤制备:  The traditional Chinese medicine composition used was prepared as follows:
a: 按照如下药材配方称取各组分: 木槿花 3质量份、 草石蚕 4质量份、 牡丹根皮 2 质量份、 甘草 4质量份、 白茯苓 2质量份;  a: Weigh each component according to the following medicinal formula: 3 parts by mass of hibiscus, 4 parts by mass of phytolith, 2 parts by mass of peony root, 4 parts by weight of licorice, and 2 parts by weight of peony;
b: 将草石蚕、 牡丹根、 白茯苓粉碎后与木槿花、 甘草混合, 加入去离子水室温浸泡 6小时, 所加水量为药材总质量的 5倍;  b: The grass stone silkworm, the peony root and the white peony are crushed, mixed with hibiscus and licorice, and added with deionized water for 6 hours at room temperature, and the added water is 5 times of the total mass of the medicinal material;
c: 之后在 50~60°C下加热煎煮 4小时, 将所得提取液进行过滤。  c: After heating and boiling at 50 to 60 ° C for 4 hours, the resulting extract was filtered.
效果测试:  Performance test:
每个实施例均选择 50人进行试用,试用者的入选标准为患有青春痘或因曾经患有青 春痘而造成面部有色素沉斑。 For each of the examples, 50 people were selected for trial. The tester's selection criteria were for acne or because they had ever had blue Spring pox causes pigmentation and ecchymosis on the face.
使用方法: 用各实施例制备的面膜 50ml浸润面膜专用无纺布, 敷在患者面部 25分 钟左右, 每日 1次。  Method of use: Mask prepared with each example 50 ml infiltrated mask special non-woven fabric, applied to the patient's face for about 25 minutes, once a day.
疗效评定标准: 使用者用后青春痘减少、 炎症减轻、 红色变浅为有效; 青春痘完全 消失为痊愈; 色斑变浅变少为有效; 色斑完全消失为痊愈。  Efficacy evaluation criteria: After the user reduced acne, inflammation decreased, red lightened to be effective; acne completely disappeared to cure; the pigmentation became less effective and less effective; the stain disappeared completely to cure.
试用结果: 实施例 1~3的使用者连续试用 3周后青春痘有效率达到 91%, 治愈率达 至 Ij 70~80%, 色斑有效率达到 88%, 色斑治愈率达到 65~78%; 实施例 4~6的使用者连续 试用 2周后青春痘有效率达到 95%, 治愈率达到 78~89%, 色斑有效率达到 94%, 色斑 治愈率达到 80~90%。  Trial results: The users of Examples 1~3 have a pimple efficiency of 91% after 3 weeks of continuous trial, the cure rate reaches 70% to 80%, the stain efficiency is 88%, and the stain cure rate reaches 65~78. %; The users of Examples 4~6 had an effective rate of 95% after 2 weeks of continuous trial, the cure rate reached 78-89%, the stain efficiency was 94%, and the stain cure rate reached 80-90%.
典型例子介绍:  A typical example is introduced:
万某, 25岁, 网络工程师, 工作需长期面对电脑, 脸上经常长痘痘, 面部暗沉, 使 用本发明实施例 1的产品 3周后, 痘痘消失了, 皮肤也更加水润嫩白。  Wanmou, 25 years old, network engineer, needs to face the computer for a long time. The face often has acne and the face is dull. After using the product of the first embodiment of the invention for 3 weeks, the acne disappears and the skin is more moist and tender. White.
刘某, 17岁, 学生, 由于升学压力大, 作息时间不规律, 脸上长满了青春痘, 脸上 还几处色斑, 使用本发明实施例 5的产品 2周后, 大部分痘痘都消失了, 色斑得到明显 淡化, 皮肤显得白皙。 以上所述, 仅是本发明的较佳实施例而已, 并非对本发明做任何形式上的限制, 故凡 未脱离本发明技术方案的内容, 依据本发明的技术实质对以上实施例所做的任何简单修 改、 等同变化与修饰, 均仍属于本发明技术方案的范围内。  Liu, 17 years old, student, due to the pressure of further study, irregular schedule, face full of acne, several spots on his face, after using the product of Example 5 of the present invention for 2 weeks, most of the acne All disappeared, the stains were noticeably faded, and the skin appeared white. The above is only the preferred embodiment of the present invention, and is not intended to limit the present invention in any way. Therefore, any of the above embodiments can be made according to the technical essence of the present invention without departing from the technical solution of the present invention. Simple modifications, equivalent changes and modifications are still within the scope of the technical solutions of the present invention.

Claims

权 利 要 求 书 、 一种用于治疗青春痘色素沉斑和美白的面膜, 其特征在于, 面膜配方中包含如下质 量份的各组份: 微量元素组合物 1~3份、 胶原蛋白 3~5份、 富氢富氧水 25~35份、 玻 尿酸 0.1 0.5份、 超氧化物歧化酶 1~5份、 羟乙基纤维素 4~6份、 丙二醇 10~20份、 防腐剂 0.05~0.1份; 其中, 所述微量元素组合物为葡萄糖酸锌、 亚硒酸钠中的一种或 两种, 富氢富氧水为富氢水和富氧水的混合物。 The invention provides a facial mask for treating acne pigmentation and whitening, characterized in that the mask comprises the following components in parts by mass: 1 to 3 parts of trace element composition, 3 to 5 parts of collagen 25 to 35 parts of hydrogen-rich oxygen-enriched water, 0.1 0.5 parts of hyaluronic acid, 1 to 5 parts of superoxide dismutase, 4 to 6 parts of hydroxyethyl cellulose, 10 to 20 parts of propylene glycol, and 0.05 to 0.1 parts of preservative; The trace element composition is one or two of zinc gluconate and sodium selenite, and the hydrogen-rich oxygen-enriched water is a mixture of hydrogen-rich water and oxygen-enriched water.
、 根据权利要求 1所述的用于治疗青春痘色素沉斑和美白的面膜, 其特征在于, 所述微 量元素组合物为葡萄糖酸锌和亚硒酸钠按照质量比 (5~10): 1组合而成。 The mask for treating acne pigmentation and whitening according to claim 1, wherein the trace element composition is zinc gluconate and sodium selenite according to a mass ratio (5 to 10): Combined.
、 根据权利要求 1所述的用于治疗青春痘色素沉斑和美白的面膜, 其特征在于, 所述富 氢富氧水为富氢水和富氧水按照质量比 1: ( 1-3 ) 的组合。 The mask for treating acne pigmentation and whitening according to claim 1, wherein the hydrogen-rich oxygen-rich water is hydrogen-rich water and oxygen-enriched water according to a mass ratio of 1: (1-3) The combination.
、 根据权利要求 1所述的用于治疗青春痘色素沉斑和美白的面膜, 其特征在于, 所述富 氢水其含氢浓度为 0.9~1.2ppm, 所述富氧水其含有的溶解氧浓度为 20~50ppm。 The mask for treating acne pigmentation and whitening according to claim 1, wherein the hydrogen-rich water has a hydrogen concentration of 0.9 to 1.2 ppm, and the oxygen-enriched water contains dissolved oxygen. The concentration is 20~50ppm.
、根据权利要求 1~4任一项所述的用于治疗青春痘色素沉斑和美白的面膜,其特征在于, 面膜配方中还含有中药组合物 5~10质量份, 所述中药组合物由如下药材配方的各组 分提取制得: 木槿花 1~5质量份、 草石蚕 2~5质量份、 牡丹根皮 1~3质量份、 甘草 2~6质量份、 白茯苓 1~4质量份。 The facial mask for treating acne pigmentation and whitening according to any one of claims 1 to 4, wherein the mask formulation further comprises 5 to 10 parts by mass of the traditional Chinese medicine composition, and the traditional Chinese medicine composition consists of The components of the following medicinal materials are extracted and prepared: 1~5 parts by mass of hibiscus, 2~5 parts by weight of grass stone, 1~3 parts by weight of peony root, 2~6 parts by weight of licorice, 1~4 mass of white peony Share.
、 根据权利要求 5所述的用于治疗青春痘色素沉斑和美白的面膜, 其特征在于, 所述药 材配方为: 木槿花 3质量份、 草石蚕 4质量份、 牡丹根皮 2质量份、 甘草 4质量份、 白茯苓 2质量份。 The facial mask for treating acne pigmentation and whitening according to claim 5, wherein the medicinal material is: 3 parts by mass of hibiscus, 4 parts by weight of sarcophagus, and 2 parts by mass of peony root bark 4 parts by mass of licorice and 2 parts by mass of white peony.
、 根据权利要求 5所述的用于治疗青春痘色素沉斑和美白的面膜, 其特征在于, 所述中 药组合物按照如下步骤的提取工艺制得: The mask for treating acne pigmentation and whitening according to claim 5, wherein the traditional Chinese medicine composition is obtained by the following extraction process:
1 ) 按药材配方称取各味药材, 将草石蚕、 牡丹根皮、 白茯苓粉碎后与木槿花、 甘草 混合, 加入去离子水室温浸泡 4~8 小时, 所加去离子水的质量为药材总质量的 4~6 倍;  1) Weigh each medicinal material according to the medicinal material formula, smash the grass stone stalk, peony root bark and white peony, mix it with hibiscus and licorice, add deionized water for 4~8 hours at room temperature, and add the quality of deionized water. 4 to 6 times the total mass of the medicine;
2) 之后在 50~60°C下加热煎煮 3~5小时, 过滤并保留滤液。  2) Then heat and decoct at 50~60 °C for 3~5 hours, filter and retain the filtrate.
PCT/CN2013/085016 2013-07-23 2013-10-11 Facial mask used for treatment of acne hyperpigmentation spot and for whitening WO2015010373A1 (en)

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