CN106474016A - A kind of scalp topical composition and scalp tonic liquid - Google Patents
A kind of scalp topical composition and scalp tonic liquid Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
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- A—HUMAN NECESSITIES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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Abstract
The present invention discloses a kind of scalp topical composition and scalp tonic liquid, and the scalp topical composition includes fullerene, plants extract and vitamin.The scalp tonic liquid of the present invention, can effectively stop that the external world gives the stimulation of scalp, safeguard hair follicle health, activate impaired hair follicle, repair impaired hair follicle, reach the solid effect for occurring and sending out.
Description
Technical field
The present invention relates to household chemicals field, more particularly to a kind of scalp topical composition and scalp tonic liquid.
Background technology
Alopecia is a kind of common skin disease, is affected by various factors such as living environment, operating pressures, currently increasingly
Many people are perplexed by alopecia, but the existing medicine for hair growth, and treatment time is long, and hair-growing effects are not good.Mesh
Before, on market, the medicine of hair growth has multiple, can substantially be divided into synthetic drug, Chinese medicine and confection, existing hair growth
Product as its preparation cost is high, growth that is defective, can not quickly promoting hair in terms of formula for growing hair reasonability, reach
Less than the effect that gets instant result.Some medicines also have certain curative effect when using, but patient is once be discontinued, and the state of an illness will
Recurrence.Most formula is simply related to the one side of phalacrosis prevention and hair generation or two aspects, and phalacrosis prevention and hair generation is that needs are many common
Same-action could produce good effect, be not merely to be added together just produce the active material of several energy hair tonic.Alopecia
Problem, is the health problem of scalp and the internal hair follicle of scalp, impaired hair follicle is repaired, healthy hair follicle is safeguarded after all,
Alopecia hair loss could really be solved the problems, such as.
Therefore, prior art has yet to be improved and developed.
Content of the invention
In view of above-mentioned the deficiencies in the prior art, it is an object of the invention to provide a kind of scalp topical composition and scalp are grown
Nutrient solution, it is intended to solve the existing medicine for hair growth, treatment time is long, and the not good problem of hair-growing effects, while described
Scalp tonic liquid, it may also be used for safeguard scalp health, reduces hair loss, anti-alopecia-stopping.
Technical scheme is as follows：
A kind of scalp topical composition, wherein, including fullerene, plants extract and vitamin.
Described scalp topical composition, wherein, the fullerene be Fullerene C20, fullerene C70, fullerene C76,
The mixture of one or more in fullerene C84.
Described scalp topical composition, wherein, the plant extract includes that grease type plants extract and water extract.
Described scalp topical composition, wherein, in parts by mass, including：Fuller olefinic carbon 60 .001-3 part, Sweet Almond Oil
0.1-5 part, flores aurantii essential oil 0.1-5 part, palmarosa essential oil 0.1-5 part, laurin oil 0.1-5 part, Bergamot 0.1-5 part,
Menthol 0.1-5 part, thick grass extract 0.1-5 part, red date extract 0.1-5 part, ginseng extract 0.1-5 part, natto powder
0.1-5 part, extraction from betula plaryphylla 0.1-5 part, black rice extract 0.1-5 part, rice fermentation extract 0.1-5 part, inulin
0.1-5 part, inositol 0.01-3 part, panthenol 0.01-3 part, biotin 0.001-1 part.
Described scalp topical composition, wherein, in parts by mass, including：Fuller olefinic carbon 60 .01-1 part, Sweet Almond Oil 0.2-
3 parts, flores aurantii essential oil 0.2-3 part, palmarosa essential oil 0.2-3 part, laurin oil 0.2-3 part, Bergamot 0.2-3 part, peppermint
Brain 0.2-3 part, thick grass extract 0.2-3 part, red date extract 0.2-3 part, ginseng extract 0.2-3 part, natto powder 0.2-3
Part, extraction from betula plaryphylla 0.2-3 part, black rice extract 0.2-3 part, rice fermentation extract 0.2-3 part, inulin 0.2-3 part,
Inositol 0.051-2 part, panthenol 0.05-2 part, biotin 0.01-0.5 part.
A kind of scalp tonic liquid, wherein, the scalp tonic liquid is comprising as above arbitrary described scalp topical composition.
Described scalp tonic liquid, wherein, the scalp tonic liquid also includes auxiliary material.
Described scalp tonic liquid, wherein, the auxiliary material includes emulsifying solubiliser, suspension stabilizer, NMF, anti-corrosion
Agent, essence and trace element.
Beneficial effect：The present invention provides a kind of scalp topical composition and scalp tonic liquid, wherein scalp topical composition
Including fullerene, plant extract（Comprising grease type, water extract）And vitamin.The scalp tonic liquid of the present invention, effectively can stop
The external world gives the stimulation of scalp, safeguards hair follicle health, activates impaired hair follicle, repairs impaired hair follicle, reaches the solid effect for occurring and sending out.
Description of the drawings
Fig. 1 is the electron-microscope scanning figure of the administration group of the embodiment of the present invention one.
Fig. 2 is the electron-microscope scanning figure of the control group of the embodiment of the present invention one.
Specific embodiment
The present invention provides a kind of scalp topical composition and scalp tonic liquid, for make the purpose of the present invention, technical scheme and
Effect is clearer, clear and definite, and the present invention is described in more detail below.It should be appreciated that specific embodiment described herein
Only in order to explain the present invention, it is not intended to limit the present invention.
The present invention provides a kind of scalp topical composition, and wherein, the scalp topical composition includes fullerene, plants extract
And vitamin.Plant extract therein is plant extracts, plants extract and water extract including grease type.
Specifically, in parts by mass, the scalp topical composition includes：
Fuller olefinic carbon 60 .001-3 part, Sweet Almond Oil 0.1-5 part, flores aurantii essential oil 0.1-5 part, palmarosa essential oil 0.1-5 part, laurin
Oily 0.1-5 part, Bergamot 0.1-5 part, menthol 0.1-5 part, thick grass extract 0.1-5 part, red date extract 0.1-5
Part, ginseng extract 0.1-5 part, natto powder 0.1-5 part, extraction from betula plaryphylla 0.1-5 part, black rice extract 0.1-5 part, greatly
Rice extractive from fermentative 0.1-5 part, inulin 0.1-5 part, inositol 0.01-3 part, panthenol 0.01-3 part, biotin 0.001-1 part.
Preferably, in parts by mass, the scalp topical composition includes：
Fuller olefinic carbon 60 .01-1 part, Sweet Almond Oil 0.2-3 part, flores aurantii essential oil 0.2-3 part, palmarosa essential oil 0.2-3 part, laurin oil
0.2-3 part, Bergamot 0.2-3 part, menthol 0.2-3 part, thick grass extract 0.2-3 part, red date extract 0.2-3 part,
Ginseng extract 0.2-3 part, natto powder 0.2-3 part, extraction from betula plaryphylla 0.2-3 part, black rice extract 0.2-3 part, rice
Extractive from fermentative 0.2-3 part, inulin 0.2-3 part, inositol 0.051-2 part, panthenol 0.05-2 part, biotin 0.01-0.5 part.
It is furthermore preferred that in parts by mass, the scalp topical composition includes：
Fuller olefinic carbon 60 .01-0.6 part, Sweet Almond Oil 0.5-1 part, flores aurantii essential oil 0.5-1 part, palmarosa essential oil 0.5-1 part, laurin
Oily 0.5-1 part, Bergamot 0.5-1 part, menthol 0.5-1 part, thick grass extract 0.5-1 part, red date extract 0.5-1
Part, ginseng extract 0.5-1 part, natto powder 0.5-2 part, extraction from betula plaryphylla 0.5-1 part, black rice extract 0.5-2 part, greatly
Rice extractive from fermentative 0.7-2 part, inulin 0.5-2 part, inositol 0.1-1 part, panthenol 0.1-1 part, biotin 0.05-0.1 part.
Vitamin therein can be vitamin A, Cobastab, vitamin C, vitamin D, vitamin E, biotin（Raw
Thing element）Deng in one or more mixing, but not limited to this.
As fullerene surface has a large amount of double bonds, free radical performance is absorbed with strong, can be used as the removing of free radical
Agent and antioxidant are applied to the industries such as biomedicine, pharmaceutical chemistry and cosmetics.Fullerene（Fullerene) it is simple substance carbon
The third allotrope being found.Any be made up of a kind of element of carbon, with spherical, ellipticity, or tubular structure is present
Material, can be called fullerene, therefore fullerene refers to a class material.
The fullerene of the present invention is with Cn（C represents carbon, and n represents more than 32 integer）Represent, can be single substance,
It can be mixture.For example, the fullerene of the present invention can be Fullerene C20, fullerene C70, fullerene C76, fullerene C84
Or arbitrarily several mixture therein.Wherein, the fullerene of the present invention is preferably Fullerene C20 or fullerene C70.
When the scalp topical composition of the present invention acts on scalp, scalp can be cleaned, alleviate hair follicle inflammation, hair follicle is produced
Raw beneficial effect.When oligotrichosis, hair follicle can be activated, induction hair follicle quantity increases, and induces follicle keratinocytes
Propagation, promotes the generation of interior cutaneous vessel growth factor VEGF, promotes the distribution of capillary at hair follicle, and reinforcing hair follicle is to nutrients
The absorption of matter, plays a part of to promote hair tonic.
The scalp topical composition of the present invention makes the hair follicle growth phase longer when acting on scalp, fur is more luxuriant, dense, black
Bright, hair follicle quantity showed increased, and dandruff and fuel-displaced problem can be improved, alleviate stress, promote sleep.
When the scalp topical composition of the present invention acts on hair, hair more flexible can be made, more shiny black, more
Smooth, bifurcated is difficult, is difficult hair loss.
Additionally, the scalp topical composition of the present invention can be also added to the formulas such as hair tonic, hair care, hair washing and hair care
In, play a part of hair-growing and hair care hair care.
The present invention also provides a kind of scalp tonic liquid, and wherein, the scalp tonic liquid includes scalp external application as above
Composition.
Further, described scalp tonic liquid, in parts by mass, including following components：
Fuller olefinic carbon 60 .01-0.6 part, Sweet Almond Oil 0.5-1 part, flores aurantii essential oil 0.5-1 part, palmarosa essential oil 0.5-1 part, laurin
Oily 0.5-1 part, Bergamot 0.5-1 part, menthol 0.5-1 part, thick grass extract 0.5-1 part, red date extract 0.5-1
Part, ginseng extract 0.5-1 part, natto powder 0.5-2 part, extraction from betula plaryphylla 0.5-1 part, black rice extract 0.5-2 part, greatly
Rice extractive from fermentative 0.7-2 part, inulin 0.5-2 part, inositol 0.1-1 part, panthenol 0.1-1 part, biotin 0.05-0.1 part.
In addition, described scalp tonic liquid can be arranged in pairs or groups, some auxiliary materials are used cooperatively, and the difference with specific reference to purpose can be arranged in pairs or groups
Some variety classeses or the auxiliary material of content, for example, add some emulsifying solubiliser, suspension stabilizer, NMF, preservative, perfume (or spice)
Smart, micro- etc..For example, the emulsifying solubiliser can be tween20（Polysorbas20）、tween40（Polysorbate40）、
tween60（Polysorbate60）、tween80（Tween 80）, Cremophor RH40, PEG-60 rilanit special, CO40 hydrogenation castor
Sesame oil, 35 Emulsifier EL-60 of EL, LRI, PPG-26 butylol polyether, sorbitan fatty ester or sucrose-fatty
One or more in ester etc..The suspension stabilizer is in hydroxyethyl cellulose, xanthans, carboxymethylcellulose calcium etc.
One or more.The NMF is one or more in glycerine, butanediol, propane diols, sorbierite, polyethylene glycol etc..
The preservative is one or more in benzoic acid, Sodium Benzoate, potassium sorbate, calcium propionate etc..The essence can be
For plant essence, or animal class essence.The trace element is one or more in iodine, copper, iron, zinc etc..
It should be noted that, above-mentioned a variety of auxiliary materials are only example, and those skilled in the art can be made when in the face of respective demand
Different auxiliary materials or additive is used, these should all belong to protection scope of the present invention.
Embodiment one：
Scalp topical composition, by weight, including：Fuller olefinic carbon 60 .01-0.6 part, Sweet Almond Oil 0.5-1 part, flores aurantii essential oil
0.5-1 part, palmarosa essential oil 0.5-1 part, laurin oil 0.5-1 part, Bergamot 0.5-1 part, menthol 0.5-1 part is big
Careless extract 0.5-1 part, red date extract 0.5-1 part, ginseng extract 0.5-1 part, natto powder 0.5-2 part, Japanese birch bark carry
Take thing 0.5-1 part, black rice extract 0.5-2 part, rice fermentation extract 0.7-2 part, inulin 0.5-2 part, inositol 0.1-1 part,
Panthenol 0.1-1 part, biotin 0.05-0.1 part.
One instantiation is as follows：By weight, including：Fuller olefinic carbon 60 .3 part, 0.25 part of Sweet Almond Oil, flores aurantii essential oil
0.8 part, 0.7 part of palmarosa essential oil, 0.7 part of laurin oil, 0.65 part of Bergamot, 0.75 part of menthol, thick grass extract
0.9 part, 0.6 part of red date extract, 0.55 part of ginseng extract, 0.1 part of natto powder, 0.85 part of extraction from betula plaryphylla, black rice
1.5 parts of extract, 1.2 parts of rice fermentation extract, 1.6 parts of inulin, 0.7 part of inositol, 0.4 part of panthenol, 0.08 part of biotin.
Its preparation process includes：
1）, the Sweet Almond Oil of instantiation recipe ratio, flores aurantii essential oil, palmarosa essential oil, laurin oil and Bergamot are mixed
Conjunction obtains miscella, then menthol is dissolved in miscella, after stirring, is added thereto to fullerene, ultrasound
After 30 minutes, stirred to being completely dissolved to obtain mixture afterwards.Reuse solubilizer such as LRI I is obtained by standby after said mixture solubilising；
2）, by the thick grass extract of instantiation recipe ratio, red date extract, ginseng extract, natto powder, Japanese birch bark extract
Thing, black rice extract, rice fermentation extract and inulin are dissolved in the water, and after being sufficiently stirred for dissolving, add EDTA-2Na, centrifugation
Filter, clear liquid is standby to obtain II；
3）, I and II is mixed after, stand overnight, centrifugal filtration, add inositol, panthenol and biotin in clear liquid so as to fully molten
Solution.
Subjects:Male C57BL/6 mouse, back rosin paraffin（1: 1）Depilation, is randomly divided into 7 groups, per group 10
Only.Each group mouse is administered once daily sooner or later, takes appropriate uniform application in epilating area, and continuous use to skin enters stand-down
（Observation terminal）.Fringe time and observation terminal time that every mouse is entered growth period by resting stage is recorded, in observation terminal
Time, the disconnected neck of mouse put to death, and it is the new piliation of 2.5cm × 2 .5cm to take back same area area, weighs, carries out after unhairing
Pathological analysis.Statistical analysis each tested material convert mice time, observation terminal time and gross weight difference.
100 microlitres of uniform application are taken in C57 hero mouse back, be administered daily, compare blank group and experimental group week about
Difference.During administration, drug effect is judged by observing the change of mouse back skin color and fur growing state. contrast,
The Time transfer receiver of the graying blackening of mouse skin of back in experimental group is short according to group, and mouse hair growth period, longer fur was more luxuriant, dense
Close, shiny black.After administration 10 days, administration group mouse back hair is grown completely.Dye through HE, mouse back fur hair follicle number
The Histological evaluation of amount is as depicted in figs. 1 and 2, it can be seen that administration group hair follicle quantity showed increased, and all containing abundant
Melanin, is shown to be the hair follicle of health, and the hair follicle quantity of control group does not have increase, and do not contain melanin.
Embodiment two：Contrast test
Physiological saline group
One group of embodiment
Pure fullerene group：As fullerene is pulverulence, and dissolubility is poor, it is impossible to is directly applied to mouse back, is
Fullerene can be applied in little category back, it is multiple that the method for referenced patent application number 200580049615.2 is prepared for C60-PVP
Compound, it is known that fullerene is active material in this compound, PVP is inert and nothing external application excitant.By C60-PVP
The aqueous solution is applied in mouse back epilating area to verify effect of pure fullerene
Plant extract group（Without fullerene）
Minoxidil group（The 3% minoxidil aqueous solution）
Table 1
| Group | Fringe time | Observation terminal time | Gross weight（mg/6 cm2） |
| Physiological saline group | 14.80±1.07 | 18.5±0.82 | 51.70±7.31 |
| One group of embodiment | 8.89±1.12 | 23.9±1.17 | 90.07±7.12 |
| Pure fullerene group | 11.37±1.11 | 21.78±1.15 | 60.02±7.73 |
| Plant extract group（Without fullerene） | 13.21±1.23 | 20.71±1.29 | 55.39±6.89 |
| Minoxidil group | 9.95±1.06 | 21.77±1.3 | 85.12±8.01 |
From table 1 it follows that the scalp topical composition of the present invention is shortening mouse hair stand-down, in terms of extending growth period
Pure fullerene group, the plant extract group without fullerene is substantially better than, while also superior to minoxidil group.
In sum, the scalp topical composition of the present invention and scalp tonic liquid, are beneficial to the generation of hair, it is adaptable to many
The alopecia of property is planted, hair tonic can be showed at short notice, the effect that sends out is educated, treatment time is short, and hair-growing effects are good.
It should be appreciated that the application of the present invention is not limited to above-mentioned citing, and for those of ordinary skills, can
To be improved according to the above description or convert, all these modifications and variations should all belong to the guarantor of claims of the present invention
Shield scope.
Claims (8)
1. a kind of scalp topical composition, it is characterised in that including fullerene, plant extract and vitamin.
2. scalp topical composition according to claim 1, it is characterised in that the fullerene is Fullerene C20, fowler
The mixture of one or more in alkene C70, fullerene C76, fullerene C84.
3. scalp topical composition according to claim 1, it is characterised in that the plant extract includes that grease type plants extract
And water extract.
4. scalp topical composition according to claim 1, it is characterised in that in parts by mass, including：Fullerene
0.001-3 part, Sweet Almond Oil 0.1-5 part, flores aurantii essential oil 0.1-5 part, palmarosa essential oil 0.1-5 part, laurin oil 0.1-5 part,
Bergamot 0.1-5 part, menthol 0.1-5 part, thick grass extract 0.1-5 part, red date extract 0.1-5 part, ginseng are extracted
Thing 0.1-5 part, natto powder 0.1-5 part, extraction from betula plaryphylla 0.1-5 part, black rice extract 0.1-5 part, rice fermentation are extracted
Thing 0.1-5 part, inulin 0.1-5 part, inositol 0.01-3 part, panthenol 0.01-3 part, biotin 0.001-1 part.
5. scalp topical composition according to claim 4, it is characterised in that in parts by mass, including：Fullerene
0.01-1 part, Sweet Almond Oil 0.2-3 part, flores aurantii essential oil 0.2-3 part, palmarosa essential oil 0.2-3 part, laurin oil 0.2-3 part, Buddhist
Hand mandarin orange essential oil 0.2-3 part, menthol 0.2-3 part, thick grass extract 0.2-3 part, red date extract 0.2-3 part, ginseng extract
0.2-3 part, natto powder 0.2-3 part, extraction from betula plaryphylla 0.2-3 part, black rice extract 0.2-3 part, rice fermentation extract
0.2-3 part, inulin 0.2-3 part, inositol 0.051-2 part, panthenol 0.05-2 part, biotin 0.01-0.5 part.
6. a kind of scalp tonic liquid, it is characterised in that the scalp tonic liquid is comprising as the arbitrary described scalp of claim 1 ~ 5
Topical composition.
7. scalp tonic liquid according to claim 6, it is characterised in that the scalp tonic liquid also includes auxiliary material.
8. scalp tonic liquid according to claim 7, it is characterised in that the auxiliary material include emulsifying solubiliser, suspend steady
Determine agent, NMF, preservative, essence and trace element.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611168412.1A CN106474016A (en) | 2016-12-16 | 2016-12-16 | A kind of scalp topical composition and scalp tonic liquid |
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| CN201611168412.1A CN106474016A (en) | 2016-12-16 | 2016-12-16 | A kind of scalp topical composition and scalp tonic liquid |
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Cited By (5)
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| CN107519046A (en) * | 2017-08-01 | 2017-12-29 | 深圳慧镁尔科技有限公司 | A kind of anticreep strengthen the hair hair growth composition, preparation method and applications |
| CN110420131A (en) * | 2019-08-23 | 2019-11-08 | 镇江大美瑞珍麦迪森生物技术有限公司 | A kind of anticreep is strong to send out nourishing liquid and preparation method thereof |
| CN110585087A (en) * | 2019-10-11 | 2019-12-20 | 茂名市瑜丰沉香创意产业有限公司 | Agilawood essential oil shampoo and preparation method thereof |
| WO2020137707A1 (en) * | 2018-12-28 | 2020-07-02 | 小林製薬株式会社 | Topical composition containing d-chiro-inositol |
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| CN110585087A (en) * | 2019-10-11 | 2019-12-20 | 茂名市瑜丰沉香创意产业有限公司 | Agilawood essential oil shampoo and preparation method thereof |
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