CN107233368A - One kind is drawn out the pus detumescence Chinese medicine external ointment and preparation method thereof - Google Patents
One kind is drawn out the pus detumescence Chinese medicine external ointment and preparation method thereof Download PDFInfo
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- CN107233368A CN107233368A CN201710478066.5A CN201710478066A CN107233368A CN 107233368 A CN107233368 A CN 107233368A CN 201710478066 A CN201710478066 A CN 201710478066A CN 107233368 A CN107233368 A CN 107233368A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The present invention relates to field of medicine preparing technology, specifically disclose one kind and draw out the pus detumescence Chinese medicine external ointment and preparation method thereof.Described ointment is made up of the raw material components comprising following parts by weight：5~15 parts of pouzolzia zeylanica extractive of general flavone；20~30 parts of stearic acid；10~20 parts of glycerin monostearate；8~15 parts of albolene；8~15 parts of atoleine；5~10 parts of triethanolamine；10~15 parts of glycerine；5~10 parts of azone；0.1~0.5 part of ethylparaben；1~3 part of lauryl sodium sulfate；100~150 parts of water.Ointment of the present invention is that, using pouzolzia zeylanica extractive of general flavone as active component, experiment proves that it has the effect for promoting ulcer wound surface healing and eliminating abscess, and ointment outward appearance exquisiteness of the present invention is easy to apply, denseness is moderate, it is heat-resisting, resist cold, centrifugation is stable.
Description
Technical field
The present invention relates to field of medicine preparing technology, and in particular to one kind is drawn out the pus detumescence Chinese medicine external ointment and its preparation side
Method.
Background technology
Pouzolzia zeylanica Pouzolzia zeylanica (L.) Benn.Var.microphylla (Wedd.) W.T.Wang.
It is a kind of conventional national tradition medicine in south China area for Urticaceae Pouzolzia plant, also known as " purulence, which is shown in, to disappear ", " grass of drawing out the pus "
Thing, is mainly used in the treatment of acute mastitis and various suppurative skin infections.
Now there are some researches show, pouzolzia zeylanica extract have detumescence of drawing out the pus, remove necrosis and promote granulation, accelerate skin wound healing,
Anti-inflammatory, analgesia etc. are acted on, and by the pouzolzia zeylanica general flavone of purification with macroreticular resin there is significant extracorporeal anti-inflammatory to act on,
The growth of subcutaneous abscess can be suppressed, promote wound healing, be the active site of the plant.But up to the present have no with racemosus mist
The preparation that water Pueraria lobota general flavone is developed as active component, especially external ointment preparation.
The content of the invention
The technical problems to be solved by the invention be to provide one kind draw out the pus detumescence Chinese medicine external ointment, it is with racemosus fog
Pueraria lobota extractive of general flavone is prepared as active component, and the ointment outward appearance exquisiteness prepared is easy to apply, and denseness is moderate, heat-resisting,
Cold-resistant, centrifugation is stable.
Above-mentioned technical problem to be solved by this invention, is achieved by the following technical programs：
One kind draw out the pus detumescence Chinese medicine external ointment, be made up of the raw material components comprising following parts by weight：
5~15 parts of pouzolzia zeylanica extractive of general flavone；20~30 parts of stearic acid；10~20 parts of glycerin monostearate；
8~15 parts of albolene；8~15 parts of atoleine；5~10 parts of triethanolamine；10~15 parts of glycerine；5~10 parts of azone；
0.1~0.5 part of ethylparaben；1~3 part of lauryl sodium sulfate；100~150 parts of water.
Preferably, described detumescence Chinese medicine external ointment of drawing out the pus, is made up of the raw material components comprising following parts by weight：
8~12 parts of pouzolzia zeylanica extractive of general flavone；25~30 parts of stearic acid；10~15 parts of glycerin monostearate；
8~12 parts of albolene；8~12 parts of atoleine；5~8 parts of triethanolamine；11~13 parts of glycerine；6~8 parts of azone；Buddhist nun
Golden 0.1~0.2 part of the ethyl ester of pool；1~2 part of lauryl sodium sulfate；100~130 parts of water.
Preferably, described water is purified water.
Preferably, described pouzolzia zeylanica extractive of general flavone is prepared via a method which to obtain：
(1) pouzolzia zeylanica medicinal material is taken, petroleum ether refluxing extraction is used, extraction fluid obtains filter residue；
(2) filter residue is extracted with alcohol reflux, obtains pouzolzia zeylanica ethanol extract；
(3) it is pouzolzia zeylanica ethanol extract is active constituent-enriched through macroporous resin column again, produce described racemosus mist
Water Pueraria lobota extractive of general flavone；The active constituent-enriched specific method of described macroporous resin column is：Pouzolzia zeylanica ethanol is extracted
Thing is adsorbed in macroporous resin column, removal of impurities is first eluted with water, then with the ethanol elution that volume fraction is 50~70%, collect ethanol
Eluent, is concentrated under reduced pressure into flowing soaking paste, is freeze-dried, and crushes, produces pouzolzia zeylanica extractive of general flavone.
It is further preferred that macroporous resin column described in step (3) is low pole or non-polar macroporous resin post；The use of water
Measure as 2~3BV, the consumption of ethanol is 2~5BV.
It is further preferred that macroporous resin column described in step (3) is AB-8 macroporous resin columns.
The preparation method of above-mentioned detumescence Chinese medicine external ointment of drawing out the pus, is comprised the following steps：
(1) water-bath after stearic acid, glycerin monostearate, albolene and atoleine, mixing is weighed by weight to add
Thermosol is turned to oil phase；Pouzolzia zeylanica extractive of general flavone, triethanolamine, glycerine, azone, Ni Bo are weighed by weight
Heating water bath is to being completely dissolved as aqueous phase after golden ethyl ester, lauryl sodium sulfate and water, mixing；
(2) aqueous phase is added in oil phase, stirring, emulsification produce described detumescence Chinese medicine external ointment of drawing out the pus.
Preferably, in the preparation method, emulsifying temperature is 85~95 DEG C in step (2), and emulsification times are 5~8min.
Most preferably, in the preparation method, emulsifying temperature is 85 DEG C in step (2), and emulsification times are 5min.
Whether outward appearance exquisiteness is easy to apply, it is necessary to which emphasis considers ointment for exploitation for ointment formulation, denseness it is whether moderate with
And the factor such as heat-resisting, cold-resistant, dewatering ability, and the raw material of these factors and ointment composition and be formulated it is closely related, raw material
Composition or formula difference can all cause the change of above-mentioned factor, even huge change；In addition, the preparation technology of ointment is to upper
State factor and also have and have a certain impact.Because detumescence Chinese medicine external ointment of the present invention of drawing out the pus is yellow with pouzolzia zeylanica total
Ketone extract is active component, and prior art there are no the report of pouzolzia zeylanica extractive of general flavone ointment dosage form, therefore
Inventor is needed to grope and constantly improve the raw material composition and formula of ointment formulation by substantial amounts of experimental study and prepare
Technique, so as to obtain the optimal ointment formulation of property.
Beneficial effect：The invention provides a kind of brand-new detumescence Chinese medicine external ointment of drawing out the pus, it is with pouzolzia zeylanica
Extractive of general flavone is active component, and experiment proves that it has the effect for promoting ulcer wound surface healing and eliminating abscess, and this
The described ointment outward appearance exquisiteness of invention is easy to apply, and denseness is moderate, heat-resisting, resists cold, and centrifugation is stable.
Brief description of the drawings
Fig. 1 is medicine group and variation diagram of the matrix group with time ulcer healing rate in embodiment 4.
Fig. 2 is medicine group and variation diagram of the matrix group with time abscess detumescence rate in embodiment 5.
Embodiment
The present invention is explained further below in conjunction with specific embodiment, but embodiment does not do any type of limit to the present invention
It is fixed.
Detumescence Chinese medicine external ointment standards of grading of drawing out the pus in following examples are as follows：
(1) appearance character：Ointment should it is uniform, fine and smooth, with Shi Dang Dot consistence, easy to apply on skin or mucous membrane,
Each 2 points, 10 points of full marks.
(2) dewatering ability：Each group ointment is weighed respectively appropriate in centrifuge tube, 3000r/min centrifugation 30min, observation
Whether there is profit layering demulsifying phenomenon.10 points of full marks.
(3) heat-resistant stability that resists cold is tested：It is respectively that each group ointment is appropriate in closed plastic box, 39 DEG C of baking oven constant temperature 30
My god, in -20 DEG C of refrigerators 24 hours, different temperature are represented, observation whether there is water-oil separating or thicker caking phenomenon.Cold-resistant 5 points of experiment,
5 points of heat-resistant experiment, 10 points of full marks.
(4) pH value is determined：Take each group ointment to add appropriate pure water to draw to mix and hook respectively, use tricks to determine each group.According to 2015
Emulsion-type matrix PH requirements as defined in version pharmacopeia annex, it is 10 points of full marks that O/W type matrix, which is not more than 8.3, PH 6 to 8.3, remaining
For 0 point.
(5) AGP test is tested：Sodium chloride 2.64g is weighed, potassium chloride 0.12g, calcium chloride 0.18g, the 300ml that adds water is molten
Solution, produces ringer's solution.Agar 6g is taken to add in ringer's solution, heating water bath dissolving is cooled to 60 DEG C.Plus ferric trichloride test solution
6 drops, are mixed.In the test tube for pouring into 6 same sizes preheated in advance immediately, loading amount is that upright standing is extremely away from test tube mouthful about 2cm
Solidification, it is standby.Each group ointment 1g loading amounts are weighed in certain equipped with (37 DEG C) warps above Agar substrate test tube, are then put in insulating box
After time, the distance (discoloration section length) that medicine permeates into agar is surveyed.Scored according to its diffusivity, 10 points of full marks.It is orthogonal
Grade form is shown in Table 1.
Table 1 draw out the pus detumescence Chinese medicine external ointment grade form
Embodiment 1 draw out the pus detumescence Chinese medicine external ointment preparation
Draw out the pus detumescence Chinese medicine external ointment composition of raw materials：10 parts of pouzolzia zeylanica extractive of general flavone；24 parts of stearic acid；It is single
11 parts of tristerin；10 parts of albolene；10 parts of atoleine；6 parts of triethanolamine；12 parts of glycerine；7 parts of azone,
0.1 part of ethylparaben；1.4 parts of lauryl sodium sulfate；120 parts of purified water；
The pouzolzia zeylanica extractive of general flavone is prepared via a method which to obtain：Pouzolzia zeylanica medicinal material is taken to carry out powder
It is broken, medicinal material coarse powder 500g is weighed, is placed in round-bottomed flask, 8 times of amount 80 DEG C of petroleum ether refluxing extractions 2 times, each 1h are separately added into；
Filter residue is flung to after petroleum ether, is added 8 times of 70% alcohol refluxs of amount and is extracted 3 times, each 1h, filtration, merging filtrate is concentrated under reduced pressure into
Without alcohol taste, adding water makes fully dissolving, centrifuges (3000r/min) 10min, takes supernatant to add water and adjusts concentration to 0.3g crude drugs/ml
And pH is adjusted to 5；Above-mentioned sample solution is added in AB-8 macroporous resin columns (5.0 × 30cm of Φ), loading flow velocity 2BV/h, plus 2BV
Water elution removal of impurities, plus 60% ethanol 2BV are eluted with 2BV/h flow velocity, are collected ethanol eluate, are concentrated under reduced pressure into flowing soaking paste,
Freeze-drying, crushes, produces pouzolzia zeylanica extractive of general flavone；
Draw out the pus detumescence Chinese medicine external ointment preparation method：
(1) water-bath after stearic acid, glycerin monostearate, albolene and atoleine, mixing is weighed by weight to add
Thermosol is turned to oil phase；Pouzolzia zeylanica extractive of general flavone, triethanolamine, glycerine, azone, Ni Bo are weighed by weight
Heating water bath is to being completely dissolved as aqueous phase after golden ethyl ester, lauryl sodium sulfate and water, mixing；
(2) aqueous phase is added in oil phase, stirring, emulsification produce described detumescence Chinese medicine external ointment of drawing out the pus；The emulsification
Temperature is 85 DEG C, and emulsification times are 5min.
Scored, what the present embodiment was prepared draws out the pus detumescence Chinese medicine external ointment total score for 50 points, wherein appearance character
10 points, 10 points of dewatering ability, resist cold 10 points of heat-resistant experiment, and pH value determines 10 points, 10 points of AGP test.Illustrate that the present invention is obtained
Ointment outward appearance exquisiteness it is easy to apply, denseness is moderate, heat-resisting, resists cold, and centrifugation is stable.
Embodiment 2 draw out the pus detumescence Chinese medicine external ointment preparation
Draw out the pus detumescence Chinese medicine external ointment composition of raw materials：12 parts of pouzolzia zeylanica extractive of general flavone；30 parts of stearic acid；It is single
15 parts of tristerin；12 parts of albolene；12 parts of atoleine；5 parts of triethanolamine；11 parts of glycerine；6 parts of azone,
0.1 part of ethylparaben；1 part of lauryl sodium sulfate；100 parts of purified water；
The pouzolzia zeylanica extractive of general flavone is prepared via a method which to obtain：Pouzolzia zeylanica medicinal material is taken to carry out powder
It is broken, medicinal material coarse powder 500g is weighed, is placed in round-bottomed flask, 8 times of amount 80 DEG C of petroleum ether refluxing extractions 2 times, each 1h are separately added into；
Filter residue is flung to after petroleum ether, is added 8 times of 70% alcohol refluxs of amount and is extracted 3 times, each 1h, filtration, merging filtrate is concentrated under reduced pressure into
Without alcohol taste, adding water makes fully dissolving, centrifuges (3000r/min) 10min, takes supernatant to add water and adjusts concentration to 0.3g crude drugs/ml
And pH is adjusted to 5；Above-mentioned sample solution is added in AB-8 macroporous resin columns (5.0 × 30cm of Φ), loading flow velocity 2BV/h, plus 2BV
Water elution removal of impurities, plus 60% ethanol 2BV are eluted with 2BV/h flow velocity, are collected ethanol eluate, are concentrated under reduced pressure into flowing soaking paste,
Freeze-drying, crushes, produces pouzolzia zeylanica extractive of general flavone；
Draw out the pus detumescence Chinese medicine external ointment preparation method：
(1) water-bath after stearic acid, glycerin monostearate, albolene and atoleine, mixing is weighed by weight to add
Thermosol is turned to oil phase；Pouzolzia zeylanica extractive of general flavone, triethanolamine, glycerine, azone, Ni Bo are weighed by weight
Heating water bath is to being completely dissolved as aqueous phase after golden ethyl ester, lauryl sodium sulfate and water, mixing；
(2) aqueous phase is added in oil phase, stirring, emulsification produce described detumescence Chinese medicine external ointment of drawing out the pus；The emulsification
Temperature is 85 DEG C, and emulsification times are 5min.
Scored, what the present embodiment was prepared draws out the pus detumescence Chinese medicine external ointment total score for 43 points, wherein appearance character 9
Point, 8 points of dewatering ability, resist cold 8 points of heat-resistant experiment, and pH value determines 10 points, 8 points of AGP test.Illustrate that the present invention is obtained soft
Cream outward appearance exquisiteness is easy to apply, and denseness is moderate, heat-resisting, resists cold, and centrifugation is stable.
Embodiment 3 draw out the pus detumescence Chinese medicine external ointment preparation
Draw out the pus detumescence Chinese medicine external ointment composition of raw materials：8 parts of pouzolzia zeylanica extractive of general flavone；25 parts of stearic acid；It is single
10 parts of tristerin；8 parts of albolene；8 parts of atoleine；8 parts of triethanolamine；13 parts of glycerine；8 parts of azone, Buddhist nun
Golden 0.2 part of the ethyl ester of pool；2 parts of lauryl sodium sulfate；130 parts of purified water；
The pouzolzia zeylanica extractive of general flavone is prepared via a method which to obtain：Pouzolzia zeylanica medicinal material is taken to carry out powder
It is broken, medicinal material coarse powder 500g is weighed, is placed in round-bottomed flask, 8 times of amount 80 DEG C of petroleum ether refluxing extractions 2 times, each 1h are separately added into；
Filter residue is flung to after petroleum ether, is added 8 times of 70% alcohol refluxs of amount and is extracted 3 times, each 1h, filtration, merging filtrate is concentrated under reduced pressure into
Without alcohol taste, adding water makes fully dissolving, centrifuges (3000r/min) 10min, takes supernatant to add water and adjusts concentration to 0.3g crude drugs/ml
And pH is adjusted to 5；Above-mentioned sample solution is added in AB-8 macroporous resin columns (5.0 × 30cm of Φ), loading flow velocity 2BV/h, plus 2BV
Water elution removal of impurities, plus 60% ethanol 2BV are eluted with 2BV/h flow velocity, are collected ethanol eluate, are concentrated under reduced pressure into flowing soaking paste,
Freeze-drying, crushes, produces pouzolzia zeylanica extractive of general flavone；
Draw out the pus detumescence Chinese medicine external ointment preparation method：
(1) water-bath after stearic acid, glycerin monostearate, albolene and atoleine, mixing is weighed by weight to add
Thermosol is turned to oil phase；Pouzolzia zeylanica extractive of general flavone, triethanolamine, glycerine, azone, Ni Bo are weighed by weight
Heating water bath is to being completely dissolved as aqueous phase after golden ethyl ester, lauryl sodium sulfate and water, mixing；
(2) aqueous phase is added in oil phase, stirring, emulsification produce described detumescence Chinese medicine external ointment of drawing out the pus；The emulsification
Temperature is 85 DEG C, and emulsification times are 5min.
Scored, what the present embodiment was prepared draws out the pus detumescence Chinese medicine external ointment total score for 40 points, wherein appearance character 7
Point, 8 points of dewatering ability, resist cold 7 points of heat-resistant experiment, and pH value determines 10 points, 8 points of AGP test.Illustrate that the present invention is obtained soft
Cream outward appearance exquisiteness is easy to apply, and denseness is moderate, heat-resisting, resists cold, and centrifugation is stable.
The staphylococcus aureus of embodiment 4 causes mouse skin ulcer assay
Experimental method：Kunming male mice is chosen, back shave shaving, shaving area depilatory cream loses hair or feathers.Back takes off
After hair 24h, after being anaesthetized with 0.5% yellow Jackets (1ml/100g), it is a diameter of 1.5cm's in mouse back hair removal section
Cylinder seal, along marking edge scissor under skin, as deep as flesh sarolemma.The S. aureus L-forms liquid prepared is injected in wound periphery immediately
(concentration is 4.3x10 to 0.1ml9Cfu/ml), matrix group is randomly divided into after modeling success (to prepare with reference to the method for embodiment 1
Detumescence Chinese medicine external ointment of drawing out the pus without pouzolzia zeylanica extractive of general flavone) and medicine group (embodiment 1, which is prepared, draws out the pus
Detumescence Chinese medicine external ointment), the administration of external application immediately is taken twice daily, 0.1g, successive administration 12d is administered every time.
Experimental result：Modeling next day visible mouse wound suppuration, redness, with the continuation of experiment process, medicine group and base
The matter group murine lesion surface of a wound gradually heals, and wherein the healing rate of medicine group is higher than matrix group, especially medicine group upon administration
3,7d its healing rate apparently higher than matrix group, difference has conspicuousness.In the detumescence of drawing out the pus that this explanation present invention is prepared
Medicine externally-applied ointment can accelerate the healing of ulcer wound surface.Medicine group is shown in Fig. 1 with matrix group with the change of time ulcer healing rate.
The staphylococcus aureus of embodiment 5 causes the experiment of mouse subcutaneous abscess
Experimental method：Kunming male mice is chosen, back shave shaving, shaving area depilatory cream loses hair or feathers.Back takes off
After hair 24h, after being anaesthetized with 0.5% yellow Jackets (1ml/100g), S. aureus L-forms liquid (concentration is subcutaneously injected without hair-fields in mouse
For 4.02X108Cfu/ml) 0.1ml/ only, is randomly divided into matrix group (with reference to the side of embodiment 1 after injection staphylococcus aureus 24h
The detumescence Chinese medicine external ointment of drawing out the pus without pouzolzia zeylanica extractive of general flavone that method is prepared) and medicine group (embodiment 1
Prepare detumescence Chinese medicine external ointment of drawing out the pus),.External application immediately is administered after packet, is taken twice daily, 0.1g is administered every time,
Successive administration 12d.Experimental result：2d after S. aureus L-forms are penetrated is subcutaneously injected, useless fellow occur in medicine group, matrix group mouse back, the
Two days and the 6th day, medicine group abscess detumescence speed ratio matrix group had a conspicuousness, during later stage six to ten days, with matrix group pair
Than medicine group abscess detumescence speed is fast.What the present invention was prepared draw out the pus, and detumescence Chinese medicine external ointment can accelerate abscess to disappear.Medicine
Thing group is shown in Fig. 2 with matrix group with the change of time abscess detumescence rate.
Claims (9)
- The detumescence Chinese medicine external ointment 1. one kind is drawn out the pus, it is characterised in that be made up of the raw material components comprising following parts by weight：5~15 parts of pouzolzia zeylanica extractive of general flavone；20~30 parts of stearic acid；10~20 parts of glycerin monostearate；Bai Fan 8~15 parts of intellectual circle；8~15 parts of atoleine；5~10 parts of triethanolamine；10~15 parts of glycerine；5~10 parts of azone；Ni Bo Golden 0.1~0.5 part of ethyl ester；1~3 part of lauryl sodium sulfate；100~150 parts of water.
- 2. detumescence Chinese medicine external ointment according to claim 1 of drawing out the pus, it is characterised in that by the original for including following parts by weight Material component is made：8~12 parts of pouzolzia zeylanica extractive of general flavone；25~30 parts of stearic acid；10~15 parts of glycerin monostearate；Bai Fan 8~12 parts of intellectual circle；8~12 parts of atoleine；5~8 parts of triethanolamine；11~13 parts of glycerine；6~8 parts of azone；Nipalgin 0.1~0.2 part of ethyl ester；1~2 part of lauryl sodium sulfate；100~130 parts of water.
- 3. detumescence Chinese medicine external ointment according to claim 1 or 2 of drawing out the pus, it is characterised in that described water is purified water.
- 4. detumescence Chinese medicine external ointment according to claim 1 or 2 of drawing out the pus, it is characterised in that described pouzolzia zeylanica Extractive of general flavone is prepared via a method which to obtain：(1) pouzolzia zeylanica medicinal material is taken, petroleum ether refluxing extraction is used, extraction fluid obtains filter residue；(2) filter residue is extracted with alcohol reflux, obtains pouzolzia zeylanica ethanol extract；(3) it is pouzolzia zeylanica ethanol extract is active constituent-enriched through macroporous resin column again, produce described pouzolzia zeylanica Extractive of general flavone；The active constituent-enriched specific method of described macroporous resin column is：Pouzolzia zeylanica ethanol extract is inhaled Invest in macroporous resin column, removal of impurities is first eluted with water, then with the ethanol elution that volume fraction is 50~70%, collect ethanol elution Liquid, is concentrated under reduced pressure into flowing soaking paste, is freeze-dried, and crushes, produces pouzolzia zeylanica extractive of general flavone.
- 5. detumescence Chinese medicine external ointment according to claim 4 of drawing out the pus, it is characterised in that macropore tree described in step (3) Fat post is low pole or non-polar macroporous resin post；The consumption of water is 2~3BV, and the consumption of ethanol is 2~5BV.
- 6. detumescence Chinese medicine external ointment according to claim 4 of drawing out the pus, it is characterised in that macropore tree described in step (3) Fat post is AB-8 macroporous resin columns.
- 7. the preparation method of the detumescence Chinese medicine external ointment of drawing out the pus described in claim 1 or 2, it is characterised in that include following step Suddenly：(1) it is molten that heating water bath after stearic acid, glycerin monostearate, albolene and atoleine, mixing is weighed by weight It is turned to oil phase；Pouzolzia zeylanica extractive of general flavone, triethanolamine, glycerine, azone, nipalgin second are weighed by weight Heating water bath is to being completely dissolved as aqueous phase after ester, lauryl sodium sulfate and water, mixing；(2) aqueous phase is added in oil phase, stirring, emulsification produce described detumescence Chinese medicine external ointment of drawing out the pus.
- 8. preparation method according to claim 7, it is characterised in that emulsifying temperature is 85~95 DEG C in step (2), emulsification Time is 5~8min.
- 9. preparation method according to claim 8, it is characterised in that emulsifying temperature is 85 DEG C, emulsification times in step (2) For 5min.
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| CN108186660A (en) * | 2018-03-29 | 2018-06-22 | 刘春霞 | A kind of detumescence Western medicine ointment |
| CN110038061A (en) * | 2019-06-06 | 2019-07-23 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Sen Deng -4 ointment and preparation method thereof |
| CN110664871A (en) * | 2019-09-09 | 2020-01-10 | 嘉应学院医学院 | Preparation method of compound cactus ointment |
| CN115364158A (en) * | 2022-08-31 | 2022-11-22 | 重庆希尔安药业有限公司 | Preparation method and application of traditional Chinese medicine composition paste |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186660A (en) * | 2018-03-29 | 2018-06-22 | 刘春霞 | A kind of detumescence Western medicine ointment |
| CN110038061A (en) * | 2019-06-06 | 2019-07-23 | 内蒙古自治区国际蒙医医院(内蒙古自治区蒙医药研究所) | Sen Deng -4 ointment and preparation method thereof |
| CN110664871A (en) * | 2019-09-09 | 2020-01-10 | 嘉应学院医学院 | Preparation method of compound cactus ointment |
| CN115364158A (en) * | 2022-08-31 | 2022-11-22 | 重庆希尔安药业有限公司 | Preparation method and application of traditional Chinese medicine composition paste |
| CN115364158B (en) * | 2022-08-31 | 2023-10-13 | 重庆希尔安药业有限公司 | Preparation method and application of traditional Chinese medicine composition paste |
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