CN101810704A - Combination of traditional Chinese medicine extractive with function of removing acne, preparation and use - Google Patents
Combination of traditional Chinese medicine extractive with function of removing acne, preparation and use Download PDFInfo
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- CN101810704A CN101810704A CN 201010146020 CN201010146020A CN101810704A CN 101810704 A CN101810704 A CN 101810704A CN 201010146020 CN201010146020 CN 201010146020 CN 201010146020 A CN201010146020 A CN 201010146020A CN 101810704 A CN101810704 A CN 101810704A
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Abstract
The invention relates to a combination of traditional Chinese medicine extractive with the function of removing acne, preparation and use. The combination consists of the extractive of garden burnet, purslane, loguat leaf, radix sophorae flavescentis and liquorice, wherein the weight percentage is as follows: 10-30% of the garden burnet, 10-30% of the purslane, 10-30% of the loguat leaf, 10-30% of the radix sophorae flavescentis and 10-30% of the liquorice. The preparation method comprises the following steps of: soaking the traditional Chinese medicine with ethyl alcohol to obtain soak solution, wherein the amount of the ethyl alcohol for soaking is 20-300 times of the weight of the natural plant; percolating the soak solution with a percolating pot, wherein the flow rate is 1-20mL/min, and colleting percolating solution; filtering and concentrating the percolating solution to be 10-50 times; absorbing concentrated solution with macroporous resin; eluting at many times with 10-98% ethyl alcohol; and collecting eluent, wherein the eluent comprises extractive of each traditional Chinese medicine extractive. Compared with the like product, the combination for preparing cosmetic and medicine for removing the acne has the characteristics of obvious effect, being capable of effectively removing the acne good safety.
Description
Technical field
The present invention relates to a kind of compositions and method for making and purposes with Chinese medicine extract of function of removing acne, this prescription is made up of Radix Sanguisorbae, Herba Portulacae, Folium Eriobotryae, Radix Sophorae Flavescentis and Radix Glycyrrhizae, can be used for removing the cosmetics and the medicine of acne.
Background technology
Acne are one of present modal skin problems, be in the recurrent a kind of hair follicle of adolescence, sebaceous gland chronic inflammatory disease, often form huge lump, suppurating forms abscess, form a large amount of diversified cicatrixes at last, so be again a kind of dermatoses of disfeaturing.Because the quickening of rhythm of life and the variation of dietary habit, the sickness rate of acne is in rising trend, according to interrelated data, there is nearly 80% people to suffer from acne among 12～25 years old the crowd, this potential great market, attracted many cosmetics companies exploitation treatment acne cosmetics, so the market competition of acne treatment product is with more and more fierce.
The treatment acne product of Cai Yonging mainly adopts chemical bactericide, hormone, astringent, antiinflammatory etc. in the market; though can diminish inflammation at short notice; but; owing to there is not fundamentally to solve the paathogenic factor of acne; can not suppress the secretion of sebaceous gland, the basic reason that hair follicle blocks is not removed, and cures the symptoms, not the disease; acne usually can recur soon, the phenomenon that occurs rising one after another.In addition, pathogenic bacteria is easy to generate drug resistance for the antibacterial of chemical, and the acne after the recurrence just are difficult to treatment more, form the intractable acne, and concurrent cicatrix of meeting and pigmentation, and skin is produced catastrophic consequence.
So people be starved of have effect clearly, safely, the natural Chinese medicine that has no adverse reaction removes the acne composition.
Radix Sanguisorbae mainly contains anastalsis and antiinflammatory action aspect medicinal, this hemostasis and antiinflammatory action all are by its chemical constituent that contains 3,3 ', and 4-three-O-methyl benzoaric acid is realized.
Herba Portulacae is the annual herb plant, is medicine food dual purpose plant, and the herb hyoscine has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, antiinflammatory, quenches the thirst, diuresis; Seed has the effect that makes eye bright.
Folium Eriobotryae is that tradition is used for clearing away lung-heat to relieve cough, the good medicine of stopping nausea and vomiting by lowering the adverse flow of QI, and cough-relieving should be processed usefulness, and preventing or arresting vomiting should be given birth to usefulness.
Radix Sophorae Flavescentis cures mainly heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Radix Glycyrrhizae is of many uses, and northern clinical application relaxes in moistening in the traditional Chinese medical science, the strong medicine that neutralizes, and detoxifcation, analgesia, spasmolytic, relieving cough and expelling phlegm etc., so that have anticancer pharmacological action.Give birth to curing mainly laryngopharynx swelling and pain, cellulitis, skin infection, ulcer, and detoxifcation etc.; Processed with honey cures mainly spleen and stomach function and goes down, heating cardiopalmus etc.
These five kinds of Chinese medicines all are to be used for eating or being used as medicine traditionally, replenish the needed by human body nutrient, or play the effect of regulating human mechanism.The compositions of above-mentioned five kinds of Chinese medicine extract is not in the news up to now as yet, and has not had open file to disclose these five kinds of Chinese medicines can be used for resisting skin allergy.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compositions with Chinese medicine extract of function of removing acne, and the said composition reliable effect can effectively be alleviated acne symptom, nursing skin.
Another technical problem to be solved by this invention is to provide above-mentioned preparation of compositions method with Chinese medicine extract of function of removing acne.
A technical problem more to be solved by this invention is to provide the purposes of the compositions of above-mentioned Chinese medicine extract with function of removing acne, is used for skin nursing products.
The present invention solves the problems of the technologies described above the technical scheme of being taked and is a kind of compositions with Chinese medicine extract combination of function of removing acne, wherein, described compositions is made up of the extract of five kinds of Chinese medicine Radix Sanguisorbaes, Herba Portulacae, Folium Eriobotryae, Radix Sophorae Flavescentis and Radix Glycyrrhizaes, by weight percentage, the content of described each Chinese medicine extract is: Radix Sanguisorbae 10～30%, Herba Portulacae 10～30%, Folium Eriobotryae 10～30%, Radix Sophorae Flavescentis 10～30%, Radix Glycyrrhizae 10～30%.
The concrete consumption of each component can for:
Radix Sanguisorbae 10,12,14,16,18,19,20,22,24,26,28 or 30%;
Herba Portulacae 10,12,14,16,18,19,20,22,24,26,28 or 30%;
Folium Eriobotryae 10,12,14,16,18,19,20,22,24,26,28 or 30%;
Radix Sophorae Flavescentis 10,12,14,16,18,19,20,22,24,26,28 or 30%;
Radix Glycyrrhizae 10,12,14,16,18,19,20,22,24,26,28 or 30%.
On the basis of such scheme, by weight percentage, the preferred content of described each Chinese medicine extract is: Radix Sanguisorbae 15～26%, Herba Portulacae 15～26%, Folium Eriobotryae 15～26%, Radix Sophorae Flavescentis 15～26%, Radix Glycyrrhizae 15～26%.
Should be pointed out that the percentage composition of each Chinese medicine extract among the present invention is that dry weight with compositions is a benchmark, but what often obtain is the solution that comprises said composition in preparation process.
The Chinese medicine extract preparation of compositions method with function of removing acne at above-mentioned comprises the steps:
The first step: with above-mentioned Chinese prescription with 20%～90% alcohol-pickled, the ethanol consumption that soaks usefulness is 20～300 times (being preferably 20～50 times) of Chinese medicine weight, soak;
Second step: soak is by percolation jar percolation, and flow is that per minute flows out 1～20mL, collects percolate;
The 3rd step: percolate concentrates 10～50 times after filtering, the concentrated solution macroporous resin adsorption, and the ethanol of reuse mass concentration 10%～98% is eluting repeatedly, collects eluent, comprises the compositions of Chinese medicine extract in the eluent.
Concrete, the ethanol consumption that soaks usefulness can be 20,22,25,28,30,32,35,38,40,42,45,48,50,60,80,100 of Chinese medicinal components gross weight, 120,150,180,200,220,250,280 or 300 times; Soak can concentrate 10,15,20,25,30,35,40,45 or 50 times after filtering.
On the basis of such scheme, in the first step, described alcohol-pickled for Chinese medicinal components with alcohol-pickled 2～48 hours; Or be that Chinese prescription is first with alcohol-pickled 2～48 hours, alcohol-pickled 2～48 hours of residue reuse merges the solution after soaking.
On the basis of such scheme, in the 3rd step, described eluting is 50%～90% with the mass concentration of ethanol.
The purposes of the Chinese medicine extraction compositions with function of removing acne that makes at said method is used to prepare the cosmetics or the medicine of acne, comprises cream, emulsion, astringent, gel, facial film, inuncts and lotion.
On the basis of such scheme, with the extracting solution compositions that makes through being evaporated to 1/2～1/5 of former weight, obtain composition concentrated solution, be used for preparation and remove acne cosmetics or medicine, mix mutually with the substrate of known cosmetics and medicine or adjuvant, carrier, additive, method according to routine is prepared, and wherein, described composition concentrated solution accounts for 5～10% of cosmetics or medicine gross weight.
Concrete, composition concentrated solution can account for 5,6,7,8,9 or 10% of gross weight.
The invention has the beneficial effects as follows:
The compositions of the Chinese medicine extract that the present invention obtains has the effect of removing acne through evidence, can be used in the cosmetics and the curative drug of anti-acne; Related composition has that effect is clear and definite, safety good, without any side effects and in cosmetic formulations stable characteristics; Compare with existing like product have effect obviously, can effectively eliminate acne and the good characteristics of safety.
The specific embodiment
Embodiment 1
At room temperature, get Radix Sanguisorbae, Herba Portulacae, Folium Eriobotryae, Radix Sophorae Flavescentis, Radix Glycyrrhizae each 10 kilograms (totally 50 kilograms), 1200 kilograms of soak times of ethanol with 50% are 24 hours, then soak is passed through percolation jar percolation, flow is that per minute flows out 1～10mL, collect percolate, concentrate 20～40 times through filtering the back, again with big D101 macroporous resin on the concentrated solution, ethanol eluting with 50%～90%, contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of Chinese medicine extract.
Embodiment 2
At room temperature, get Radix Sanguisorbae, Herba Portulacae, Folium Eriobotryae, Radix Sophorae Flavescentis, Radix Glycyrrhizae each 10 kilograms (totally 50 kilograms), 1500 kilograms of soak times of ethanol with 80% are 40 hours, the ethanol of residue reuse 80% soaked 40 hours for 1500 kilograms, then soak is passed through percolation jar percolation, flow is that per minute flows out 1～20mL, collect percolate, concentrate 30～40 times through filtering the back, again with big D101 macroporous resin on the concentrated solution, ethanol eluting with 70%～90% contains needed effective ingredient in the prescription of the present invention, i.e. the compositions of Chinese medicine extract in the eluent of collection.
Embodiment 3
At room temperature, get 8 kilograms of Radix Sanguisorbaes, 8 kilograms of Herba Portulacaes, 10 kilograms of Folium Eriobotryaes, 12 kilograms of Radix Sophorae Flavescentiss, 12 kilograms in Radix Glycyrrhizae (totally 50 kilograms), 1000 kilograms of soak times of ethanol with 60% are 24 hours, the ethanol of residue reuse 60% soaked 24 hours for 1000 kilograms, then soak is passed through percolation jar percolation, flow is that per minute flows out 1～15mL, collect percolate, concentrate 20～30 times through filtering the back, again with big D101 macroporous resin on the concentrated solution, ethanol eluting with 60%～90% contains needed effective ingredient in the prescription of the present invention, i.e. the compositions of Chinese medicine extract in the eluent of collection.
Embodiment 4
At room temperature, get 10 kilograms of Radix Sanguisorbaes, 8 kilograms of Herba Portulacaes, 12 kilograms of Folium Eriobotryaes, 10 kilograms of Radix Sophorae Flavescentiss, 10 kilograms in Radix Glycyrrhizae (totally 50 kilograms), 1800 kilograms of soak times of ethanol with 30% are 48 hours, then soak is passed through percolation jar percolation, flow is that per minute flows out 1～15mL, collect percolate, concentrate 20～30 times through filtering the back, again with big D101 macroporous resin on the concentrated solution, ethanol eluting with 70%～90%, contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of Chinese medicine extract.
Application examples
The liquid that embodiment 2 is obtained adopts concentrating under reduced pressure, is concentrated into 1/2nd to 1/5th of former weight, gets the composition concentrated solution of Chinese medicine extract, is used for preparation and removes the acne cream, and this goes the prescription of acne cream as shown in table 1.
Table 1
Production technology:
The first step: HANSHENGJIAO is dispersed in the deionized water, and elevated temperature to 80 ℃ simultaneously, adds other components of B phase then, stir;
Second step: each component of A phase is complete in 80 ℃ of dissolvings, stir; A is added to middle mutually homogenizing, about 4 minutes of stirring of B;
The 3rd step: add C and stirred fast mutually 1～2 minute, froth breaking is cooled to 65 ℃;
The 4th step: add the D phase, back to the 40 ℃ of addings that stir comprise each component of E phase of composition concentrated solution, the discharging that stirs, and pH value is controlled at 4.0～5.0, makes the acne cream.
The test report of the anti-acne effect of the compositions of Chinese medicine extract
Illustrate:
One, the compositions of used anti-acne Chinese medicine extract is the compositions of Chinese medicine extract of the present invention in the following test;
Two, the anti-acne test of the rabbit ear is used to observe the therapeutical effect of medicine to laboratory animal acne model;
The anti-acne test of the rabbit ear
1. materials and methods
1.1 animal
New zealand white rabbit, male and female and usefulness, the cleaning level, body weight (2.5 ± 0.2) kg is available from Nat'l Pharmaceutical ﹠ Biological Products Control Institute laboratory animal breeding farm.The quality certification number: 2000 No. 017.
1.2 reagent and instrument
Coal tar, black, pasty state are available from coke-oven plant, Beijing.
Olive oil, commercially available.
Microscope: BX250 type Olympus optical microscope.
1.3 be subjected to trial product: contain 5% anti-acne Chinese medicine extract compositions remove the acne cream
Reference product:
The blank cream that does not contain any medicine, matrix formulations is identical with the test cream.
1.4 experimental technique
Get healthy rabbit,, be coated with coal tar every day 1 time, each 0.25mL, continuous 14 days in every rabbit left side in ear side syrinx opening part 2cm * 2cm scope; Other gets 10 rabbit, and the same method is smeared for coal tar with olive oil, as the normal control group.Since the 15th day, the rabbit that is coated with coal tar is divided into totally 3 groups of model control group (using reference product), medication therapy groups (removing the acne cream with test) and normal control groups, 14 every group by the body weight stratified random.Partial smearing, every day 1 time, 2mg/cm
2, continuous 14 days.Last was smeared back 24 hours, and the rabbit ear is smeared coal tar place biopsy bark fetching, conventional formalin fixed, and paraffin embedding, section, HE dyeing, tissues observed changes under light microscopic.
2. result: anti-acne ointment is as shown in table 2 to the therapeutical effect of animal acne model.
Table 2
The result shows that the histology who goes the acne cream can effectively improve the acne animal model who contains 5% anti-acne Chinese medicine extract changes.
Claims (7)
1. compositions with Chinese medicine extract of function of removing acne, it is characterized in that: described compositions is made up of the extract of five kinds of Chinese medicine Radix Sanguisorbaes, Herba Portulacae, Folium Eriobotryae, Radix Sophorae Flavescentis and Radix Glycyrrhizaes, by weight percentage, the content of described each Chinese medicine extract is: Radix Sanguisorbae 10～30%, Herba Portulacae 10～30%, Folium Eriobotryae 10～30%, Radix Sophorae Flavescentis 10～30%, Radix Glycyrrhizae 10～30%.
2. the compositions with Chinese medicine extract of function of removing acne according to claim 1, it is characterized in that: by weight percentage, the content of described each Chinese medicine extract is: Radix Sanguisorbae 15～26%, Herba Portulacae 15～26%, Folium Eriobotryae 15～26%, Radix Sophorae Flavescentis 15～26%, Radix Glycyrrhizae 15～26%.
3. at claim 1 or 2 described preparation of compositions methods, it is characterized in that comprising the steps: with Chinese medicine extract of function of removing acne
The first step: with above-mentioned Chinese prescription with 20%～90% alcohol-pickled, the ethanol consumption that soaks usefulness is 20～300 times of Chinese medicine gross weight, soak;
Second step: soak is by percolation jar percolation, and flow is that per minute flows out 1～20mL, collects percolate;
The 3rd step: percolate concentrates 10～50 times after filtering, the concentrated solution macroporous resin adsorption, and the ethanol of reuse mass concentration 10%～98% is eluting repeatedly, collects eluent, comprises the compositions of Chinese medicine extract in the eluent.
4. the preparation of compositions method with Chinese medicine extract of function of removing acne according to claim 3 is characterized in that: in the first step, described alcohol-pickled for Chinese prescription with alcohol-pickled 2～48 hours; Or be that Chinese prescription is first with alcohol-pickled 2～48 hours, alcohol-pickled 2～48 hours of residue reuse merges the solution after soaking.
5. the preparation of compositions method with Chinese medicine extract of function of removing acne according to claim 3 is characterized in that: in the 3rd step, described eluting is 50%～90% with the mass concentration of ethanol.
6. the purposes of the compositions of the Chinese medicine extract with function of removing acne that makes at the described method of one of claim 3 to 5 is used to prepare the cosmetics or the medicine of acne, comprises cream, emulsion, astringent, gel, facial film, inuncts and lotion.
7. the purposes of the compositions of the Chinese medicine extract with function of removing acne according to claim 6, it is characterized in that: with the extracting solution compositions that makes through being evaporated to 1/2～1/5 of former weight, obtain composition concentrated solution, be used for preparation and remove acne cosmetics or medicine, wherein, described composition concentrated solution accounts for 5～10% of cosmetics or medicine gross weight.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356426A (en) * | 2013-05-26 | 2013-10-23 | 上海珍馨化工科技有限公司 | Peel-off type sanguisorba officinalis sterilizing facial mask and preparation method thereof |
| CN104382798A (en) * | 2014-11-28 | 2015-03-04 | 李正梅 | Mask and method for preparing same |
| CN105560641A (en) * | 2015-12-28 | 2016-05-11 | 李剑 | Traditional Chinese medicine composition for removing acne and application thereof |
| CN113018345A (en) * | 2021-04-09 | 2021-06-25 | 建昌帮药业有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN113384642A (en) * | 2021-07-15 | 2021-09-14 | 忧立舒医药科技(广东)有限公司 | Natural extraction compound with acne removing effect and preparation method and application thereof |
| CN115381877A (en) * | 2022-09-30 | 2022-11-25 | 西安航天基地美托邦医疗美容有限公司 | A topical skin preparation for treating acne, and its preparation method |
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| CN1201676A (en) * | 1997-06-09 | 1998-12-16 | 李香兰 | Cosmetical face film with Chinese medicines |
| CN101401879A (en) * | 2008-10-23 | 2009-04-08 | 宋兆普 | Pill for treating acne on face |
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2010
- 2010-04-13 CN CN 201010146020 patent/CN101810704B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1201676A (en) * | 1997-06-09 | 1998-12-16 | 李香兰 | Cosmetical face film with Chinese medicines |
| CN101401879A (en) * | 2008-10-23 | 2009-04-08 | 宋兆普 | Pill for treating acne on face |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356426A (en) * | 2013-05-26 | 2013-10-23 | 上海珍馨化工科技有限公司 | Peel-off type sanguisorba officinalis sterilizing facial mask and preparation method thereof |
| CN103356426B (en) * | 2013-05-26 | 2015-09-23 | 上海珍馨化工科技有限公司 | Exfoliated Radix Sanguisorbae sterilization facial film and preparation method thereof |
| CN104382798A (en) * | 2014-11-28 | 2015-03-04 | 李正梅 | Mask and method for preparing same |
| CN105560641A (en) * | 2015-12-28 | 2016-05-11 | 李剑 | Traditional Chinese medicine composition for removing acne and application thereof |
| CN113018345A (en) * | 2021-04-09 | 2021-06-25 | 建昌帮药业有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN113384642A (en) * | 2021-07-15 | 2021-09-14 | 忧立舒医药科技(广东)有限公司 | Natural extraction compound with acne removing effect and preparation method and application thereof |
| CN115381877A (en) * | 2022-09-30 | 2022-11-25 | 西安航天基地美托邦医疗美容有限公司 | A topical skin preparation for treating acne, and its preparation method |
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