CN101810556B - Combination of traditional Chinese medicine extractive with function of anti-skin aging, preparation and use - Google Patents
Combination of traditional Chinese medicine extractive with function of anti-skin aging, preparation and use Download PDFInfo
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Abstract
The invention relates to a combination of traditional Chinese medicine extractive with the function of anti-skin aging, preparation and use. The combination consists of the extractive of mulberry, radix achyranthis bidentatae, rhizoma polygonati, geranium, mangnolia officinalis, cornaceae, amomum cardamomum, pyrola and Chinese angelica, wherein the weight percentage is as follows: 1-20% of mulberry, 1-20% of radix achyranthis bidentatae, 1-20% of rhizoma polygonati, 1-20% of geranium, 1-20% of mangnolia officinalis, 1-20% of cornaceae, 1-20% of amomum cardamomum, 1-20% of pyrola and 1-20% of Chinese angelica. The preparation method comprises the following steps of: soaking the traditional Chinese medicine with ethyl alcohol to obtain soak solution, wherein the amount of the ethyl alcohol for soaking is 20-300 times of the weight of the traditional Chinese medicine; filtering and concentrating the soak solution to be 10-50 times; absorbing concentrated solution with macroporous resin; eluting at many times with 10-98% ethyl alcohol; and collecting eluent, wherein the eluent comprises extractive of each traditional Chinese medicine extractive. Compared with the like product, the combination has obvious effect, has double functions of melanin inhibiting and skin cell rebirth promoting, and has good safety.
Description
Technical field
The present invention relates to a kind of compositions and method for making and purposes with Chinese medicine extract of function of anti-skin aging, Chinese medicine composition is comprised of the extract of Fructus Mori, Radix Achyranthis Bidentatae, Rhizoma Polygonati, Flos Pelargonii, Cortex Magnoliae Officinalis, Fructus Corni, Fructus Amomi Rotundus, Herba Pyrolae and Radix Angelicae Sinensis, can be used for skin nursing, especially the cosmetics of anti aging effect.
Background technology
Defying age and skin nursing are the most important themes of cosmetics.Prove that through modern scientific research old and feeble formation is subject to the impact of many factors, and there are the indefinite problem with certain untoward reaction occurring of effect in the defying age that adopts at present and skin care cosmetics additive great majority.
Along with growth in the living standard and human sciences's accumulation of knowledge, very large variation has occured for the requirement of cosmetics in people.At present defying age additive commonly used as: vitamin E because chemical constitution is unstable, is difficult to use in cosmetics; Fruit acid, owing to have certain zest, and be difficult in cosmetics, use; Tretinoin, effect has zest by way of single, and effect is not ideal enough.So people be starved of have that effect is clear and definite, effect by way of various, safely, the natural defying age composition that has no adverse reaction.
Fructus Mori has the effect of the liver and the kidney tonifying, promoting the production of body fluid to quench thirst, loosening bowel to relieve constipation, improve visual and auditory acuity, black beard and hair, and it is edible to be particularly suitable for habitual constipation, old people's blood deficiency and constipation, anemia, alopecia, early whitening of beard and hair, insomniac.Can not only strengthen the abilities of digestive and absorption of gastrointestinal, gastrointestinal peristalsis is strengthened, play aid digestion, as to promote stool discharge effect, its contained substance such as vitamin E is in time removed and is caused the free radical of human senility, and then plays antidotal effect.
Radix Achyranthis Bidentatae is mainly used in soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, puerperal abdominal pain due to blood stasis, laryngopharynx swelling and pain etc.
Rhizoma Polygonati is mainly used in lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough of YIN-deficiency of the lung and kidney, and weakness of the spleen and stomach, both tonifying spleen-yins, strengthening the spleen gas again, the dizziness that also causes for deficiency of kidney essence, soreness of the waist and knees, early whitening of beard and hair and quenching one's thirst wait effective.
The medical value of Flos Pelargonii mainly contain pain relieving, antibiotic, put in and knit scar, strengthen cytophylaxis function, deodorization, hemostasis, benefit body.Applicable all skins have deep layer to purify and the convergence effect, the balance sebum secretion.
Cortex Magnoliae Officinalis is damp-resolving medicinal, has the merit of dampness, and the card for the treatment of retention of dampness in middle-JIAO is useful to eliminating distension.
Fructus Corni has another name called Fructus Corni, and the invigorating the liver and kidney effect strengthens for deficiency of the liver and kindey, has a dizzy spell tinnitus, the soreness of waist, frequent micturition, incessant sweating due to debility.In addition, can also consolidating channel for hemostasis, availablely control the diseases such as human female void, menorrhagia.
Fructus Amomi Rotundus is to control to tell famous medicine, and is especially suitable to the vomiting of cold syndrome of the stomach retention of damp leading to blockage of QI, also controls dysphagic.
Herba Pyrolae is used for rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Radix Angelicae Sinensis is one of the most frequently used Chinese medicine.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Above-mentioned Chinese medicine all is edible traditionally or is used as medicine, and replenishes the needed by human body nutrient, or plays the effect of balance the body mechanism.The compositions of above-mentioned each Chinese medicine extract not yet is in the news up to now, except Fructus Mori has the merit of defying age because it contains vitamin E, and has not had open file to disclose other Chinese medicines to can be used for skin nursing.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compositions with Chinese medicine extract of function of anti-skin aging, said composition reliable effect, the dual function with check melanin and promotion Skin Cell new life.
Another technical problem to be solved by this invention is to provide the preparation method of the compositions of above-mentioned Chinese medicine extract with function of anti-skin aging.
An again technical problem to be solved by this invention is to provide the purposes of the compositions of above-mentioned Chinese medicine extract with function of anti-skin aging, is used for skin nursing products.
The present invention solves the problems of the technologies described above the technical scheme of taking: a kind of compositions with Chinese medicine extract of function of anti-skin aging, wherein, described compositions is comprised of the extract of Chinese medicine Fructus Mori, Radix Achyranthis Bidentatae, Rhizoma Polygonati, Flos Pelargonii, Cortex Magnoliae Officinalis, Fructus Corni, Fructus Amomi Rotundus, Herba Pyrolae and Radix Angelicae Sinensis, and the quality percentage composition of arbitrary component all is no more than 20% of total amount.
On the basis of such scheme, by weight percentage, the content of described each Chinese medicine extract is: Fructus Mori 1～20%, Radix Achyranthis Bidentatae 1～20%, Rhizoma Polygonati 1～20%, Flos Pelargonii 1～20%, Cortex Magnoliae Officinalis 1～20%, Fructus Corni 1～20%, Fructus Amomi Rotundus 1～20%, Herba Pyrolae 1～20%, Radix Angelicae Sinensis 1～20%.
The concrete consumption of each component can for:
Fructus Mori 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Radix Achyranthis Bidentatae 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Rhizoma Polygonati 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Flos Pelargonii 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Cortex Magnoliae Officinalis 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Fructus Corni 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%
Fructus Amomi Rotundus 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%
Herba Pyrolae 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%;
Radix Angelicae Sinensis 1,2,4,5,6,8,10,12,13,14,15,16,18 or 20%.
On the basis of such scheme, by weight percentage, the preferred content of described each natural plant extracts is: Fructus Mori 2～15%, Radix Achyranthis Bidentatae 2～15%, Rhizoma Polygonati 2～15%, Flos Pelargonii 2～15, Cortex Magnoliae Officinalis 2～15%, Fructus Corni 2～15%, Fructus Amomi Rotundus 2～15%, Herba Pyrolae 2～15%, Radix Angelicae Sinensis 2～15%.
Should be pointed out that the percentage composition of each Chinese medicine extract among the present invention be dry weight take compositions as benchmark, but what often obtain in preparation process is the solution that comprises said composition.
Preparation method for the compositions of the above-mentioned Chinese medicine extract with function of anti-skin aging comprises the steps:
The first step: with above-mentioned Chinese prescription with 20%～80% alcohol-pickled, the ethanol consumption that soaks usefulness is 20～300 times of Chinese prescription weight, gets soak;
Second step: concentrated 10～50 times after filtering of soaks, the concentrated solution macroporous resin adsorption, the ethanol of using again mass concentration 10%～98% is eluting repeatedly, and the collection eluent comprises the compositions of each Chinese medicine extract in the eluent.
Concrete, the ethanol consumption that soaks usefulness can be 20,22,25,28,30,32,35,38,40,42,45,48,50,60,80,100 of Chinese medicinal components gross weight, 120,150,180,200,220,250,280 or 300 times; Soak can concentrate 10,15,20,25,30,35,40,45 or 50 times after filtering.
On the basis of such scheme, in the first step, described alcohol-pickled for Chinese prescription with alcohol-pickled 2～48 hours; Or use first alcohol-pickled 2～48 hours for Chinese prescription, residue is used alcohol-pickled 2～48 hours again, merges the solution after soaking.
On the basis of such scheme, in the second step, described eluting is 40%～90% with the mass concentration of ethanol.
The purposes of the compositions of the Chinese medicine extract with function of anti-skin aging that makes for said method for the preparation of skin care cosmetics, comprises cream, emulsion, astringent, gel, facial film, inuncts and lotion.
On the basis of such scheme, with the extracting solution compositions that makes through being evaporated to 1/2～1/5 of former weight, obtain composition concentrated solution, for the preparation of skin care cosmetics, mix mutually with the substrate of known cosmetics and medicine or adjuvant, carrier, additive, method according to routine is prepared, and wherein, described composition concentrated solution accounts for 5～10% of skin care cosmetics gross weight.
Concrete, composition concentrated solution can account for 5,6,7,8,9 or 10% of gross weight.
The invention has the beneficial effects as follows:
The compositions of the resulting Chinese medicine extract of the present invention can be used in cosmetics and the curative drug of skin care through the effect that evidence has antioxidation, promotion Skin Cell new life; Related composition has that effect is clear and definite, safety good, without any side effects and in cosmetic formulations stable characteristics; Compare dual function and the good characteristics of safety that have successful, have check melanin and promotion Skin Cell new life with existing like product.
The specific embodiment
Embodiment 1
At room temperature, get Fructus Mori, Radix Achyranthis Bidentatae, Rhizoma Polygonati, Flos Pelargonii, Cortex Magnoliae Officinalis, Fructus Corni, Fructus Amomi Rotundus, Herba Pyrolae, Radix Angelicae Sinensis each 10 kilograms (totally 90 kilograms), 1200 kilograms of soak times of ethanol with 50% are 24 hours, residue soaked 24 hours with 1200 kilograms of 50% ethanol again, then the solution after will soaking merges, through concentrating 20 times behind the 200 purpose strainer filterings, again with macroporous resin on the concentrated solution, with 40% ethanol eluting, contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of each Chinese medicine extract.
Embodiment 2
At room temperature, get Fructus Mori, Radix Achyranthis Bidentatae, Rhizoma Polygonati, Flos Pelargonii, Cortex Magnoliae Officinalis, Fructus Corni, Fructus Amomi Rotundus, Herba Pyrolae, Radix Angelicae Sinensis each 10 kilograms (totally 90 kilograms), 1500 kilograms of soak times of ethanol with 80% are 40 hours, residue soaked 40 hours with 1500 kilograms of 80% ethanol again, then the solution after will soaking merges, through concentrating 30 times behind the 200 purpose strainer filterings, again with macroporous resin on the concentrated solution, with 70% ethanol eluting, contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of each Chinese medicine extract.
Embodiment 3
At room temperature, get 5 kilograms in Fructus Mori, 7 kilograms of Radix Achyranthis Bidentataes, 7 kilograms of Rhizoma Polygonatis, 10 kilograms of Flos Pelargoniis, 10 kilograms of Cortex Magnoliae Officinalis, 12 kilograms of Fructus Corni, 12 kilograms of Fructus Amomi Rotunduss, 12 kilograms of Herba Pyrolaes and 15 kilograms of Radix Angelicae Sinensis (totally 90 kilograms), 1000 kilograms of soak times of ethanol with 60% are 24 hours, residue soaked 24 hours with 1000 kilograms of 60% ethanol again, the solution of the solution after then will soaking merges, through concentrating 30 times behind the 200 purpose strainer filterings, again with macroporous resin on the concentrated solution, ethanol eluting with 80%, contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of each Chinese medicine extract.
Embodiment 4
At room temperature, get 15 kilograms in Fructus Mori, 8 kilograms of Radix Achyranthis Bidentataes, 8 kilograms of Rhizoma Polygonatis, 12 kilograms of Flos Pelargoniis, 5 kilograms of Cortex Magnoliae Officinalis, 8 kilograms of Fructus Corni, 10 kilograms of Fructus Amomi Rotunduss, 8 kilograms of Herba Pyrolaes and 6 kilograms of Radix Angelicae Sinensis (totally 90 kilograms), 1800 kilograms of soak times of ethanol with 30% are 48 hours, through concentrating 20～30 times behind the 200 purpose strainer filterings, again with macroporous resin on the concentrated solution, ethanol eluting with 70%～90%, contain needed effective ingredient in the prescription of the present invention in the eluent of collecting, i.e. the compositions of each Chinese medicine extract.
Application examples
The liquid that embodiment 2 is obtained adopts concentrating under reduced pressure, is concentrated into 1/2nd to 1/5th of former weight, gets the composition concentrated solution of Chinese medicine extract, and for the preparation of the anti aging effect cream, the prescription of this anti aging effect cream is as shown in table 1.
Table 1
Production technology:
The first step: HANSHENGJIAO is dispersed in the deionized water, and increases the temperature to simultaneously 80 ℃, then add other components of B phase, stir;
Second step: each component of A phase in 80 ℃ of dissolve completes, is stirred; A is added to mutually middle homogenizing, about 4 minutes of stirring of B;
The 3rd step: added C phase rapid stirring 1～2 minute, froth breaking is cooled to 65 ℃;
The 4th step: add the D phase, comprise each component of E phase of composition concentrated solution after stirring to 40 ℃ of addings, the discharging that stirs, pH value is controlled at 4.0～5.0, makes the anti aging effect cream.
Chinese prescription is to the antioxidation of aging model mice and promote Skin Cell new life's test report:
Illustrate:
One, the compositions of used Chinese medicine extract is the compositions of delay aging drug extract of the present invention in the following test;
Two, the antioxidation test of aging model mice is used for observing the anti-aging effects of medicine;
Three, promote the newborn test of Skin Cell to be used for observing medicine to the defying age maintenance effect of skin.
Chinese prescription is to the antioxidation of aging model mice:
1. laboratory animal: Kunming mouse, 10 ages in week, body weight 20-30 gram, Chinese Academy of Sciences's laboratory animal provides.
2. key instrument and reagent:
2.1 instrument: spectrofluorophotometer
Ultraviolet-visible spectrophotometer
The low-temperature and high-speed centrifuge;
2.2 reagent: vitamin E
Thiobarbituricacidα-(Sigma company)
Tetraethoxypropane (Fluka company)
MDA, SOD, GSH-PX, MAO-B measure test kit.
3. test method: animal is divided into blank group, positive controls, Chinese medicine experimental group; Each treated animal injection of d-galactose causes aging model, and hair is shaved in the north, and experimental group smears that Chinese medicine extract prescription (5%W/W), positive controls are smeared vitamin E (5%W/W), negative control is smeared distilled water.Once a day, continuous 60 days.
4. measure: animal eye socket venous blood sampling, measure MDA, SOD, GSH-PX, MAO-B:
MAD adopts the thiobarbituricacidα-method; SOD adopts xanthine oxidase;
GSH-PX adopts two sulfur Nitrodracylic acid methods; MAO-B adopts the aniline hydrochloride method.
5. result: the antioxidation of the compositions of Chinese medicine extract is as shown in table 2:
Table 2
| Group | Number of animals | MDA(μmol/L) | SOD(NU/mL) | GSH-PX(U.ml/min) | MAD(U.ml/min) |
| Negative control | 15 | 55.13±22.20 | 9560±2260 | 16.47±8.30 | 0.25±0.12 |
| Positive control | 15 | 23.93±2.06 | 13185±684 | 17.79±4.71 | 0.13±0.06 |
| Chinese medicine extract | 15 | 28.41±4.20 | 13086±942 | 18.36±4.74 | 0.11±0.06 |
The result shows that oxygen-derived free radicals can be effectively removed in the Chinese medicine extract combination.
Chinese prescription is to promoting the newborn effect of skin:
1. material: the 3T3 fibroblast, available from Chinese Academy of Sciences's Shanghai Institute of Cell Biology.
2. main agents:
MTT (Sigma company)
Trypsin DIFCO company)
PRMI-1640 culture fluid (GIBCO company)
3. passage is cultivated: the cell trypsinization contains the suspension of 10% calf serum PRMI-1640 culture fluid and is inoculated in 96 well culture plates, culture environment 5% carbon dioxide, 95% humidity.Inverted microscope is observed adherent situation and cellular morphology.
4. cell proliferation test: behind the nearly monolayer of 96 well culture plate Growth of Cells, be changed to the culture fluid that contains the Chinese medicine extraction compositions, the matched group culture fluid was cultivated after 48 hours, measured the cell proliferation situation with mtt assay.
5. result: the compositions of Chinese medicine extract is as shown in table 3 on the fibroblastic impact of 3T3:
Table 3
| Middle concentration | n | The OD value |
| 0mg/ml (contrast) | 5 | 11.32±4.82 |
| 5mg/ml | 5 | 37.55±13.20 |
| 10mg/ml | 5 | 50.24±15.13 |
| 15mg/ml | 5 | 70.60±13.64 |
The result shows that the compositions of Chinese medicine extract can promote fibroblast newborn.
Claims (9)
1. compositions with Chinese medicine extract of function of anti-skin aging, it is characterized in that: described compositions is by the Chinese medicine Fructus Mori, Radix Achyranthis Bidentatae, Rhizoma Polygonati, Flos Pelargonii, Cortex Magnoliae Officinalis, Fructus Corni, Fructus Amomi Rotundus, the extract of Herba Pyrolae and Radix Angelicae Sinensis forms, wherein, by weight percentage, the content of described each Chinese medicine extract is: Fructus Mori 1～20%, Radix Achyranthis Bidentatae 1～20%, Rhizoma Polygonati 1～20%, Flos Pelargonii 1～20%, Cortex Magnoliae Officinalis 1～20%, Fructus Corni 1～20%, Fructus Amomi Rotundus 1～20%, Herba Pyrolae 1～20%, Radix Angelicae Sinensis 1～20%, wherein the compositions of Chinese medicine extract be above-mentioned Chinese prescription with 20%～80% alcohol-pickled, the ethanol consumption that soaks usefulness is 20～300 times of Chinese prescription weight, get soak, concentrated 10～50 times after filtering of soaks, the concentrated solution macroporous resin adsorption, the compositions of the Chinese medicine extract that repeatedly obtains behind the eluting with the ethanol of mass concentration 10%～98% again.
2. compositions according to claim 1, it is characterized in that: by weight percentage, the content of described each Chinese medicine extract is: Fructus Mori 2～15%, Radix Achyranthis Bidentatae 2～15%, Rhizoma Polygonati 2～15%, Flos Pelargonii 2～15%, Cortex Magnoliae Officinalis 2～15%, Fructus Corni 2～15%, Fructus Amomi Rotundus 2～15%, Herba Pyrolae 2～15%, Radix Angelicae Sinensis 2～15%.
3. the preparation method of claim 1 or 2 described compositionss is characterized in that comprising the steps:
The first step: with above-mentioned Chinese prescription with 20%～80% alcohol-pickled, soaking with the ethanol consumption is 20～300 times of Chinese prescription weight, gets soak;
Second step: concentrated 10～50 times after filtering of soaks, the concentrated solution macroporous resin adsorption, the ethanol of using again mass concentration 10%～98% is eluting repeatedly, and the collection eluent comprises the compositions of Chinese medicine extract in the eluent.
4. the preparation method of compositions according to claim 3 is characterized in that: in the first step, described alcohol-pickled for Chinese prescription with alcohol-pickled 2～48 hours; Or use first alcohol-pickled 2～48 hours for Chinese prescription, residue is used alcohol-pickled 2～48 hours again, merges the solution after soaking, and gets soak.
5. the preparation method of compositions according to claim 3, it is characterized in that: in the second step, described eluting is 40%～90% with the mass concentration of ethanol.
6. the purposes of the compositions that makes of the described method of claim 3 for the preparation of skin care cosmetics, comprises cream, emulsion, astringent, gel, facial film, inuncts and lotion.
7. purposes according to claim 6, it is characterized in that: the extracting solution compositions that makes through being evaporated to 1/2～1/5 of former weight, is obtained composition concentrated solution, for the preparation of skin care cosmetics, wherein, described composition concentrated solution accounts for 5～10% of cosmetics gross weight.
8. the purposes of the compositions that makes of claim 4 or 5 described methods for the preparation of skin care cosmetics, comprises cream, emulsion, astringent, gel, facial film, inuncts and lotion.
9. purposes according to claim 8, it is characterized in that: the extracting solution compositions that makes through being evaporated to 1/2～1/5 of former weight, is obtained composition concentrated solution, for the preparation of skin care cosmetics, wherein, described composition concentrated solution accounts for 5～10% of cosmetics gross weight.
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| CN103599027B (en) * | 2013-11-29 | 2015-08-19 | 赵智朋 | A kind of balsam pear toner and preparation method thereof |
| CN106266495A (en) * | 2016-09-26 | 2017-01-04 | 上海和善化妆品有限公司 | There is Chinese medicine composition and the application improving steroid-dependent dermatitis |
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| CN1170588A (en) * | 1996-07-16 | 1998-01-21 | 郝来勤 | Pure natural plant human life energy nutritive substrate |
| CN1457818A (en) * | 2002-05-16 | 2003-11-26 | 杨文志 | Poison expelling and astheniz resisting balance pill and its preparing method |
| CN101229115A (en) * | 2006-12-13 | 2008-07-30 | 天津市弗兰德医药科技发展有限公司 | Make-up products for removing acne and freckle, and whitening and preparing method thereof |
| CN101357112A (en) * | 2008-08-05 | 2009-02-04 | 北京工商大学 | Acne-removing additive |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1170588A (en) * | 1996-07-16 | 1998-01-21 | 郝来勤 | Pure natural plant human life energy nutritive substrate |
| CN1457818A (en) * | 2002-05-16 | 2003-11-26 | 杨文志 | Poison expelling and astheniz resisting balance pill and its preparing method |
| CN101229115A (en) * | 2006-12-13 | 2008-07-30 | 天津市弗兰德医药科技发展有限公司 | Make-up products for removing acne and freckle, and whitening and preparing method thereof |
| CN101357112A (en) * | 2008-08-05 | 2009-02-04 | 北京工商大学 | Acne-removing additive |
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Address after: 200444 Shanghai city Baoshan District City Bank Road No. 121 Applicant after: Shanghai Inoherb Cosmetic Co., Ltd. Address before: 200083 Shanghai City No. 1 Lane 66 Huayuan Road Jiahe International Building 18-19 Applicant before: Shanghai Inoherb Cosmetic Co., Ltd. |
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